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Dissertations / Theses on the topic 'CTGF'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Ball, DeAnna K. "Establishment of a recombinant CTGF expression system in vitro that models CTGF processing in vivo : structural and functional characterization of multiple mass CTGF proteins /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486397841221133.

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2

Tarr, Joseph Thomas. "CTGF/CCN2: The Marionettist of Mammalian Palatogenesis." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/540676.

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Biomedical Sciences<br>Ph.D.<br>The mammalian palate develops early in embryogenesis by way of a carefully orchestrated series of temporally and spatially regulated signaling events. Molecular signaling pathways that have been proven to be vital to the process of palatogenesis include TGF-βs, BMPs, FGFs, EGF, and Wnts. The absence of connective tissue growth factor (CTGF/CCN2) has been shown previously to cause failure of proper palatogenesis, i.e. cleft palate. However, the details about the phenotype of this model of cleft palate were scarce. Additionally, CCN2 is known to interact with TGF-

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3

Huang, Bau-Lin. "Connective tissue growth factor gene regulation and function of CTGF /." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=2026641211&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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4

Cordova, Jaime Gonzalo. "Role of CTGF and TNF on fibrosis in muscular dystrophy." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066546/document.

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La dystrophie musculaire de Duchenne (DMD) est une maladie liée à l'X caractérisée par la détérioration progressive des muscles en raison de l'absence de la protéine dystrophine. Les muscles atteints chez l'homme ou dans des modèles animaux (souris mdx) présentent une fibrose, accumulation excessive de protéines de la matrice extracellulaire. Parmi les facteurs induisant la fibrose se trouvent le Facteur de Croissance de Transformation de type β (TGF-β) et le Facteur de Croissance du Tissu Conjonctif (CTGF). Ce dernier est une cible de la voie de signalisation médiée par TGF-β/SMAD et est resp

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5

Tang, Xiaodi. "The role of connective tissue growth factor (CTGF) in articular cartilage." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/25292.

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Work from our group has identified an important role for the pericellular matrix (PCM) of cartilage in mechanotransduction. This region of the matrix sequesters regulatory molecules such as fibroblastic growth factor 2 (FGF2) and releases them upon mechanical stimulation. By carrying out a proteomic analysis of PCM proteins we identified an additional regulatory molecule, connective tissue growth factor (CTGF). CTGF was of interest to us as this protein is up-regulated in osteoarthritis but its function in chondrocytes is unknown. I confirmed the pericellular localisation of CTGF in cartilage

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6

Zhou, Zhenqing. "BIOLOGICAL SIGNIFICANCE OF HEPARIN-BINDING GROWTH FACTORS HB-EGF AND CTGF." Miami University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=miami1258498601.

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7

Robinson, Richard. "Biomarker and treatment target development in muscle invasive bladder cancer." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/biomarker-and-treatment-target-development-in-muscle-invasive-bladder-cancer(9f7e3dba-9630-4d0d-b7aa-629718d02018).html.

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Introduction: The outcomes following radical treatment for bladder cancer (BC) remain poor, with 5 year overall survival (OS) rates of approximately 50% and over 5000 deaths per year in the U.K. There has been paucity of significant therapeutic developments since the introduction of cisplatinum based chemotherapy in the 1970’s. The aim of this study was to identify putative drug targets for the treatment of this aggressive form of cancer. Methods: A tissue microarray (TMA) was constructed from the cystectomy specimens of 497 BC patients and 70 controls, linked to a clinical database with exten

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8

Watts, Keira Louise. "Differential expression of connective tissue growth factor (CTGF) in fibrogenesis : regulation by simvastatin." Thesis, Keele University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398915.

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Connective Tissue Growth Factor (CTGF) is a potent, pro fibrotic mediator, which acts downstream of and in concert with Transforming Growth Factor (TGF)p, to drive fibrogenesis. Significant upregulation of CTGF has been reported in fibrogenic diseases including idiopathic pulmonary fibrosis (IPF). IPF typically features excessive fibroblast proliferation and extracellular matrix (ECM) deposition, features that may be partially due to CTGF over-expression. In this thesis, basal expression of CTGF in response to TGFp (Sng/ml) is confirmed in primary lung fibroblasts (lMR90 and HIPF). Gene expres

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9

Finckenberg, Piet. "Regulation of connective tissue growth factor (CTGF) in hypertension-induced end organ damage." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/biola/vk/finckenberg/.

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10

Han, Juliette. "The Role of TSC in Oligodendrocyte Differentiation and Myelination." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10194.

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Tuberous Sclerosis Complex (TSC) is an autosomal dominant syndrome characterized by epilepsy, intellectual disability, and autism. Recent studies have suggested that white matter abnormalities, including hypomyelination, contribute to the cognitive deficits in TSC patients, but the mechanism has remained elusive. I used the neuron-specific Tsc1 knockout mice that display a marked decrease in myelin and show that oligodendrocytes are arrested at immature stages of development in vivo resulting in a reduction in the number of myelinating cells. I established an oligodendrocyte culture system and

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11

Toda, Naohiro. "Crucial Role of Mesangial Cell-derived Connective Tissue Growth Factor in a Mouse Model of Anti-Glomerular Basement Membrane Glomerulonephritis." Kyoto University, 2018. http://hdl.handle.net/2433/232131.

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12

Ren, Jing. "Targeting non-alcoholic steatohepatitis induced by high fat feeding and type 2 diabetes in a preclinical model." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/15737.

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the developed world and it is strongly associated with metabolic derangements, such as insulin resistance, dyslipidaemia, obesity and hyperglycaemia. The prevalence of NAFLD is estimated to be up to 80% in patients with obesity or type 2 diabetes compared with 20-30% in the general adult population, reflecting that both obesity and type 2 diabetes cosegregate with NAFLD. In particular, type 2 diabetes is an independent risk factor for NAFLD progression. However despite the commonality of NAFLD, and its potent

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13

Hendesi, Honey. "CONNECTIVE TISSUE GROWTH FACTOR (CTGF/CCN2) REGULATES OSTEOBLAST CYTOSKELETAL REORGANIZATION AND MOTILITY AND ENHANCES DIFFERENTIATION VIA BINDING TO INTEGRIN RECEPTORS AND ACTIVATION OF DOWNSTREAM SIGNALINGS." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/263674.

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Cell Biology<br>Ph.D.<br>Connective Tissue Growth Factor (CTGF) is a matricellular protein that has been shown to mediate cell adhesion, and as a consequence, it regulates cell proliferation, migration, differentiation and gene transcription. Although previous in vivo and in vitro studies supported the anabolic role of CTGF in skeletogenesis, to date mechanisms of this effect remain unknown. So far, no specific receptor has been identified for CTGF, although previous studies have shown that integrins can serve as functional signaling receptors for CTGF. The CTGF-integrin interaction initiates

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14

Dahlbom, Moa. "Gene Expression of CTGF in Human Dermal Fibroblasts When Exposed to TGF-β and IL-1α". Thesis, Örebro universitet, Institutionen för läkarutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-36966.

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15

Laug, Roderich [Verfasser], Norbert [Gutachter] Schütze, and Petra [Gutachter] Högger. "Funktionsaufklärung von CYR61 und CTGF in mesenchymalen Stammzellen und Lungenendothelzellen / Roderich Laug. Gutachter: Norbert Schütze ; Petra Högger." Würzburg : Universität Würzburg, 2014. http://d-nb.info/1109749775/34.

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16

Dillinger, Andrea E. [Verfasser], and Rudolf [Akademischer Betreuer] Fuchshofer. "Involvement of CTGF in eye development and the pathology of glaucoma / Andrea E. Dillinger ; Betreuer: Rudolf Fuchshofer." Regensburg : Universitätsbibliothek Regensburg, 2019. http://d-nb.info/1202364314/34.

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17

Mohammed, Ali Idel. "Analysis of the effect of TGF-β and IL-1α on CTGF, Sema7A, collagen V and lumican expression". Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-65428.

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18

Balschun, Katharina [Verfasser], and Steffen [Akademischer Betreuer] Hauptmann. "Expressionsanalyse von Cyr61 und CTGF in den Borderline-Tumoren und Karzinomen des Ovars / Katharina Balschun. Betreuer: Steffen Hauptmann." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2009. http://d-nb.info/1024937402/34.

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19

Gebhardt, Susanne. "Expression, biochemische Charakterisierung und biologische Analyse des CONNECTIVE TISSUE GROWTH FACTOR." kostenfrei, 2008. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2008/2956/.

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20

Lambi, Alex G. "The Intricate Role of Connective Tissue Growth Factor (CTGF/CCN2) in Prenatal Osteogenesis: A Heretofore Oversimplified Dogma of the CCN Field." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/233693.

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Cell Biology<br>Ph.D.<br>Connective tissue growth factor (CTGF/CCN2) is axiomatically necessary for proper skeletal development and function. We need not look further than the studies that have been done to date utilizing mice genetically engineered to lack CTGF production. These CTGF null or knockout (KO) mice fail to form a normal murine skeleton and instead yield one littered with bony dysmorphisms, including incompetent craniofacial development, kinked limb bones, and misshapen ribs that are not conducive to proper respiratory function. As a result, the global lack of CTGF is incompatible

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21

Pi, Liya. "The role of connective tissue growth factor (ctgf) in oval cell aided liver regeneration in the 2-aaf/phx model." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010022.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 162 pages. Includes Vita. Includes bibliographical references.

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22

Tank, Juliane [Verfasser]. "Analyse und RNAi- vermittelte Suppression von CTGF als proinflammatorischer und profibrotischer Mediator in murinen und humanen kardialen Fibroblasten / Juliane Tank." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1135957185/34.

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23

Steinhoff, Laura Allison [Verfasser]. "Assoziation eines funktionellen CTGF Promotorpolymorphismus (CCN2c.-945) auf Herzerholung unter mechanischer Kreislaufunterstützung bei Patienten mit idiopathischer dilatativer Kardiomyopathie / Laura Allison Steinhoff." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1075757207/34.

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24

Zhang, Xuemei. "Src Kinase Signaling Regulates Connective Tissue Growth Factor (CTGF/CCN2) Induction by Transforming Growth Factor-Beta 1 (TGF-b1) in Osteoblasts." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/63095.

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Anatomy<br>Ph.D.<br>Connective tissue growth factor (CTGF/CCN2) is a cysteine rich, extracellular matrix protein that acts as an anabolic growth factor to regulate osteoblast differentiation and function. In osteoblasts, CTGF is induced by transforming growth factor beta 1 (TGF-β1) where it acts as a downstream mediator of TGF-β1 induced extracellular matrix production. The molecular mechanisms that control CTGF induction by TGF-β1 in osteoblasts are not understood. We have previously demonstrated the requirement of Src, Erk and Smad signaling for TGF-β1 induced CTGF promoter activity in prima

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25

Koga, Kenichi. "MicroRNA-26a inhibits TGF-β-induced extracellular matrix protein expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy". Kyoto University, 2016. http://hdl.handle.net/2433/204573.

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26

Ayubi, Nawid. "mRNA-Expression vom connective tissue growth factor (CTGF) und hepatocyt growth factor (HGF) nach laserinduzierter Thermotherapie (LITT) und chirurgischer Resektion experimenteller Lebermetastasen." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/183/index.html.

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27

Friedrich, Emily [Verfasser], and Margarete [Akademischer Betreuer] Goppelt-Strübe. "Regulation der Genexpression von Connective Tissue Growth Factor (CTGF) in humanen Tubulusepithelzellen unter Einfluss von Hypoxie / Emily Friedrich. Gutachter: Margarete Goppelt-Strübe." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2013. http://d-nb.info/1054342210/34.

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28

Burney, Kareem S. "Evalulation [sic] of sustained release of antisense oligonucleotide from Poly DL (Lactide-Co-Glycolide) microspheres targeting fibrotic growth factors CTGF and TGF-Beta1." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0001194.

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29

Sobral, Lays Martin. "Participação de Smad7 e CTGF na transdiferenciação de miofibroblastos gengivais e análise da influência dos miofibroblastos na proliferação e invasão de carcinomas espinocelulares orais." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288721.

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Orientador: Ricardo Della Coletta<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-17T00:49:35Z (GMT). No. of bitstreams: 1 Sobral_LaysMartin_D.pdf: 3033003 bytes, checksum: 6019edf717b2f1f1088e0f9584909707 (MD5) Previous issue date: 2010<br>Resumo: Miofibroblastos são células mesenquimais caracterizadas pela expressão da isoforma ? da actina de músculo liso (?-SMA) e pela secreção de proteínas da matriz extracelular, fatores de crescimento e proteases. Estas células desempenham um papel importante na repar

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30

Haydont, Valérie. "La fibrose intestinale radio-induites : des mécanismes moléculaires aux applications thérapeutiques : rôles du TGF-Beta1, du CTGF et de la voie de transduction du signal Rho/Rock." Paris 11, 2006. http://www.theses.fr/2006PA11T058.

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L'entérite radique chronique est une fibrose intestinale faisant suite à une irradiation accidentelle ou à une radiothérapie antitumorale de la zone abdominale et pelvienne. L'étude des mécanismes moléculaires qui régissent le développement et le maintien de la fibrose nous a permis de caractériser les rôles respectifs du CTGF, des faibles concentrations de TGF-β1, et de la voie de transduction Rho. La compréhension des interactions entre ces différents acteurs a abouti au développement de 2 stratégies thérapeutiques. En traitement curatif, nous montrons qu'une inhibition de Rho par la pravast

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31

Panek, Anna [Verfasser]. "Rolle des Connective Tissue Growth Factors (CTGF) und des PKC-enhanced Protein-Phosphatase 1 Inhibitors (KEPI) für die Funktion des adulten Herzen : Studien an transgenen Tiermodellen / Anna Naila Panek." Berlin : Freie Universität Berlin, 2008. http://d-nb.info/1023375095/34.

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32

Koskela, von Sydow Anita. "Regulation of fibroblast activity by keratinocytes, TGF-β and IL-1α : studies in two- and three dimensional in vitro models". Doctoral thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-48225.

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Dysregulated wound healing is commonly associated with excessive fibrosis. Connective tissue growth factor (CTGF/CCN2) is characteristically overexpressed in fibrotic diseases and stimulated by transforming growth factor-β (TGF-β) in dermal fibroblasts. Reepithelialisation and epidermal wound coverage counteract excessive scar formation. We have previously shown that interleukin-1α (IL-1α) derived from keratinocytes conteracts TGF-β-stimulated CTGF-expression. The aim of this thesis was to further explore the effects of keratinocytes and IL-1α on gene and protein expression, as well as pathway

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33

Rai, Sushma Debi. "Tumour specific CTCF point mutations abrogate CTCF function." Thesis, University of Essex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442523.

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34

Joelsons, Gabriel. "Avaliação molecular das disfunções subclínicas do enxerto renal : quantificação gênica de perforina, TIM3, FOXP3, TGF-β, CTGF e CD138 no sangue periférico de pacientes com função estável que realizaram biópsia protocolar no terceiro mês após o transplante renal". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/106762.

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Introdução: A sobrevivência em curto prazo dos transplantes renais tem melhorado notavelmente nas últimas duas décadas. No entanto, a sobrevivência em longo prazo de enxertos e pacientes ainda são muito inferiores ao desejado e a maioria dos enxertos são perdidos por falecimento dos receptores e deterioração crônica da função do enxerto. Acredita-se que a maior parte das lesões que resultam em encurtamento da sobrevida do enxerto se iniciam logo após o transplante e muitas vezes são subclínicas. O desenvolvimento de biomarcadores não invasivos para identificar com precisão as lesões sub-clínic

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35

He, Hongbin. "Studies on the genetic control of infection and hepatic disease in schistosoma haematobium and schistosoma japonicum infections in human." Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX20720.

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La bilharziose reste un problème de santé majeur. L'équipe du Pr Dessein a montré que les infections élevées étaient déterminées par un locus majeur en 5q31 et que des polymorphismes dans un gène à ce locus,IL13, aggravent l'infection. Notre premier objectif était d'évaluer si des variants d'autres gènes de la voie de l'IL13 intervenaient dans le contrôle de l'infection. Nous avons observé une association entre le SNP rs324013, dans le promoteur de STAT6,et les niveaux d'infection à S. haematobium. Ce polymorphisme a un effet additif avec le polymorphisme IL13rs1800925. Ce SN modifie la fixati

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36

Mäkivierikko, Aram. "CTG Carbon Calculator." Thesis, Uppsala University, Department of Information Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101181.

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<p>A carbon dioxide emission calculator for buildings created by the U.S.-based company CTG Energetics, Inc. and based on a Excel file has been converted to a ASP.NET / SQL Server web application. Carbon dioxide emissions are calculated using data given by the user (i.e. floor area, workdays per year) in combination with statistical data used in user-selectable presets (i.e. building type, climate zone, type of water-using fixtures). In most cases a custom value can be inserted instead of using a preset. Emissions attributable both directly and indirectly to the building such as building energ

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Kung, Johnny Tsun-Yi. "Genome-wide Analysis of Ctcf-RNA Interactions." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11618.

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Ctcf is a "master regulator" of the genome that plays a role in a variety of gene regulatory functions as well as in genome architecture. Evidence from studying the epigenetic process of X-chromosome inactivation suggests that, in certain cases, Ctcf might carry out its functions through interacting with RNA. Using mouse embryonic stem (ES) cells and a modified protocol for UV-crosslinking and immunoprecipitation followed by high-throughput sequencing (CLIP-seq), Ctcf is found to interact with a multitude of transcripts genome-wide, both protein-coding mRNA (or noncoding transcripts therein) a

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38

Roberts, Julian Charles. "Identification and characterisation of novel DNA targets of the transcription factor CTCF and analysis of selected CTCF-DNA interactions." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709829.

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Justo, Lourenço Salomão Gonçalves. "Controle total de frotas - CTF." Florianópolis, SC, 2002. http://repositorio.ufsc.br/xmlui/handle/123456789/84403.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.<br>Made available in DSpace on 2012-10-20T09:01:20Z (GMT). No. of bitstreams: 0<br>Nos últimos anos, a economia mundial e a economia brasileira têm sofrido mudanças importantes. Fusões, aquisições e alianças estratégicas têm se multiplicado. Parte considerável destas mudanças relaciona-se com profundas alterações nos sistemas de valores de todos os segmentos industriais. A busca da competitividade relaciona-se cada vez mais com a busca do ótimo sistêmico alé

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Ganebo, Bereket. "Stripe Based CTF Gradient correction." Thesis, KTH, Skolan för teknik och hälsa (STH), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-105882.

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Abstract Structure of membrane protiens can be determined by diffirent techniques.Electron Crystallography is one of the commonly used techniques to determine their structure in atomic or near atomic resolution.Due to the crystal disorder and poor CTF correction techniques the resolution obtained from this technique is not ideal.To push the resolution to the ideal, single particle refinement with local averaging for crystal disorder and improved CTF correction methodology for tilted data sets has been applied.With this approach applied to microsomal glutathione S-transferase 1(MGST1) membrane

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41

Kita, Georgie-Xanthi. "Characterization of the CTCF isoforms and BORIS, the CTCF paralogue, in normal and cancer breast tissues and investigation of their role in breast tumourigenesis." Thesis, University of Essex, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537934.

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Mukhopadhyay, Rituparna. "Chromatin Insulators and CTCF: Architects of Epigenetic States during Development." Doctoral thesis, Uppsala University, Department of Animal Development and Genetics, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4241.

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<p>A controlled and efficient coordination of gene expression is the key for normal development of an organism. In mammals, a subset of autosomal genes is expressed monoallelically depending on the sex of the transmitting parent, a phenomenon known as genomic imprinting.</p><p>The imprinted state of the <i>H19</i> and <i>Igf2</i> genes is controlled by a short stretch of sequences upstream of <i>H19</i> known as the imprinting control region (ICR). This region is differentially methylated and is responsible for the repression of the maternally inherited <i>Igf2</i> allele. It harbors hypersens

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Kocabas, Evren. "Atypical P-type ATPases, CtpE and CtpF from Mycobacteria tuberculosis." Digital WPI, 2013. https://digitalcommons.wpi.edu/etd-theses/910.

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"Mycobacterium tuberculosis causes tuberculosis, one of the most life-threatening diseases of all time. It infects the host macrophages and survives in its phagosome. The host phagosome is a very hostile environment where M. tuberculosis copes with high concentration of transition metals (Zn2+, Cu2+), low levels of others (Mn2+, Fe2+) and acidic pH. P-ATPases are membrane proteins that transport various ions against their electrochemical gradients utilizing the energy of ATP hydrolysis. Based on their primary sequences; seven of the twelve mycobacterial ATPases are classified as putative heavy

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Fischer, Sabine. "Inducible systems for the characterization of insulating and repressing motifs." kostenfrei, 2009. http://d-nb.info/999863568/34.

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45

Paris, Christian. "The role of CTCF in the life cycle of human papillomavirus." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/6367.

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Papillomaviruses (PV) are epithelium specific DNA viruses that can cause health problems ranging from harmless warts to invasive cancer. Papillomavirus induced tumours most often arise in the cervix where human papillomavirus (HPV) infections were shown to cause 99.7 % of all malignancies. This study aims to map binding sites of the multifunctional host protein CCCTC binding factor (CTCF) to the papillomavirus genome, validate them and determine the function of CTCF in the papillomavirus life cycle. Computer predictions of CTCF binding sites in the sequence of 8 different PV revealed a CTCF bi

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Schmidt, Kristina H. "CTG trinucleotide repeat instability in Escherichia coli." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/14353.

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In order to identify cellular factors that affect trinucleotide repeat stability, changes in the length of a (CTG)<sub>43</sub> repeat were studied over 140 generations in wild-type <i>Escherichia coli</i> and in strains that are deficient in post-replicative mismatch repair, secondary structure repair and homologous recombination. It is shown that (CTG)<sub>43</sub> inserted into pUC18 expands and contracts in wild-type <i>E. coli</i> in an orientation-dependent manner that is unaffected by transcription. In cells deficient in post-replicative mismatch repair (CTG)<sub>43</sub> repeat instabi

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47

Sanchez, Donald S. Jr. "Assessing BEAR: Tool Usability for Wireless CTF." DigitalCommons@CalPoly, 2021. https://digitalcommons.calpoly.edu/theses/2325.

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Capture the Flag (CTF) is a common and popular type of event in the cyber security space with audiences ranging from large security conference participants to even those in middle or high school. Event participants bring their favorite set of tools and any level of knowledge they have to compete against other teams in solving cyber security related challenges. These types of challenges can range anywhere from reverse engineering programs and hacking WiFi to utilizing interesting command line commands and messing with browser developer consoles. There are plenty of general CTF events that happe

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48

Pant, Vinod. "CTCF and Epigenetic Regulation of the H19/Igf2 Locus." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3540.

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Heath, Helen Elizabeth. "CTCF: comprehending.the complex functions of an 11-zinc-finger transcription factor." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10861.

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Nobelen, Suzanne van de. "Touched by CTCF analysis of a multi-functional zinc finger protein /." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/12282.

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