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Journal articles on the topic 'Cucurbitacee'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Jarial, Kumud, Rajendar Singh Jarial, and Satish Kumar Gupta. "Bacterial Spot (Xanthomonas cucurbitae) of cucurbits: A review." NBU Journal of Plant Sciences 9, no. 1 (2015): 33–39. http://dx.doi.org/10.55734/nbujps.2015.v09i01.004.

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The Cucurbitaceae also known as cucurbits, are a plant family, sometimes called the ground family, consists of around a hundred genera most of which are edible. The Cucurbitaceae family ranks among the highest of plant families for number and percentage of species used as human food. Cucumber, pumpkin, different types of gourds, melons, squash and zucchini are among the important edible plants of the family. The cultivation of these cucurbits is hampered by the attack of many pathogens and insects, out of which Xanthomonas cucurbitae (Bryan) Dowson (Syn.: Xanthomonas campestris pv. cucurbitae)

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2

Salamah, Rohmi, and Slamet Widiyanto. "Chloroform Fraction of Cucumis melo L. ‘Gama Melon Parfum’ Cytotoxicity against Breast Cancer Cell T47D and MCF7." BIO Web of Conferences 49 (2022): 02001. http://dx.doi.org/10.1051/bioconf/20224902001.

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Nature is the source of various types of phytochemicals. Some of them are unique chemical compounds only found in certain plants. For example, Cucurbitacin is found in the family Cucurbitaceae. Cucumis melo 'Gama Melon Parfum' (GMP) is a member of the Cucurbitaceae family. Unlike melons in general, GMP melons have a bitter taste. The taste is caused by the high Cucurbitacin content. These compounds are known as anti-cancer. This study aims to identify Cucurbitacin in GMP melons and determine their effects on T47D and MCF7 breast cancer cells. GMP melon fruit medium phase (20DAA) was macerated

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3

Abdel Halim, Osama B., El-Sayed M. Marawan, Ali A. El-Gamal, and Mona G. Zaghloul. "Socotroside, a New Pentacyclic Cucurbitane Glycoside from Dendrosicyos socotrana." Zeitschrift für Naturforschung B 63, no. 12 (2008): 1415–20. http://dx.doi.org/10.1515/znb-2008-1212.

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Phytochemical investigation of the ethyl acetate extract of the stem of Dendrosicyos socotrana Balf. f. resulted in the isolation of a new pentacyclic cucurbitane glycoside Socotroside, in addition to the three known cucurbitacins, dihydrocucurbitacin D, dihydrocucurbitacin F and cucurbitacin G. The structures of the isolated compounds were established on the basis of their spectral data. The isolated cucurbitacin aglycones showed marked cytotoxic activity.

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4

Ku, Jin Mo, Se Hyang Hong, Hyo In Kim, et al. "Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling." European Journal of Inflammation 16 (January 1, 2018): 1721727X1775180. http://dx.doi.org/10.1177/1721727x17751809.

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Cucurbitacins are triterpenoids commonly found in Cucurbitaceae and Cruciferae and have long been used in traditional medicine. Cucurbitacins demonstrate anti-inflammatory and anti-cancer activities. We investigated whether cucurbitacin D affects viability in breast cancer cells and its mechanism of action. An MTT assay was used to measure the viability of breast cancer cells. Western blot analysis was used to measure the expression of various modulators, such as p-p53, p-Stat3, p-Akt, and p-NF-κB. Doxorubicin and cucurbitacin D affected the viability of MCF7, MDA-MB-231, and SKBR3 cells. Cucu

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5

MATSUMOTO, Kazuhiro, Ryoji KASAI, Kazuhiro OHTANI, and Osamu TANAKA. "Minor cucurbitane-glycosides from fruits of Siraitia grosvenori (Cucurbitaceae)." CHEMICAL & PHARMACEUTICAL BULLETIN 38, no. 7 (1990): 2030–32. http://dx.doi.org/10.1248/cpb.38.2030.

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6

Soh, Désiré, Bruno Tchebemou Bakang, Ernestine Nkwengoua Tchouboun, et al. "New cucurbitane type triterpenes from Momordica foetida Schumach. (Cucurbitaceae)." Phytochemistry Letters 38 (August 2020): 90–95. http://dx.doi.org/10.1016/j.phytol.2020.05.010.

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7

Wang, Xiaojuan, Mine Tanaka, Herbenya Silva Peixoto, and Michael Wink. "Cucurbitacins: elucidation of their interactions with the cytoskeleton." PeerJ 5 (May 30, 2017): e3357. http://dx.doi.org/10.7717/peerj.3357.

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Cucurbitacins, a class of toxic tetracyclic triterpenoids in Cucurbitaceae, modulate many molecular targets. Here we investigated the interactions of cucurbitacin B, E and I with cytoskeletal proteins such as microtubule and actin filaments. The effects of cucurbitacin B, E and I on microtubules and actin filaments were studied in living cells (Hela and U2OS) and in vitro using GFP markers, immunofluorescence staining and in vitro tubulin polymerization assay. Cucurbitacin B, E and I apparently affected microtubule structures in living cells and cucurbitacin E inhibited tubulin polymerization

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8

Mcquate, Grant T., and Tadashi Teruya. "Melon Fly, Bactrocera Cucurbitae (Diptera: Tephritidae), Infestation in Host Fruits in the Southwestern Islands of Japan before the Initiation of Island-wide Population Suppression, as Recorded in Publications of Japanese Public Institutions." International Journal of Insect Science 7 (January 2015): IJIS.S24582. http://dx.doi.org/10.4137/ijis.s24582.

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Bactrocera cucurbitae (Coquillett) is a tephritid fruit fly native to the Indo-Malayan region. Its distribution, though, has extended to include Africa, temperate Asia, and a number of Pacific islands. It became established in Japan in 1919 in the Yaeyama Islands and spread north in the Southwestern Islands of Japan. It was subsequently eradicated from these islands by an eradication program that extended from 1972 to 1993. As part of an effort to develop a worldwide database on the status of fruits as hosts of melon fly, the infestation data gathered from host fruits collected in this eradica

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9

Achenbach, Hans, Konrad Horn, Xorge A. Dominguez, Carlos Rombold, and Elda G. Gómez López. "Cucurbitanes and cucurbitane-type glycosides from Ibervillea sonorae." Phytochemistry 33, no. 2 (1993): 437–45. http://dx.doi.org/10.1016/0031-9422(93)85535-y.

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10

Ramezani, Moazzameh, Melika Hasani, Fatemeh Ramezani, and Mahmood Karimi Abdolmaleki. "Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities." Pharmaceutical Sciences 27, no. 1 (2020): 1–13. http://dx.doi.org/10.34172/ps.2020.66.

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For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed, Scopus, and Google Scholar. The keywords of cucurbitacin, cucumber anticancer therapy, cytotoxic effects, chemotherapy, and inhibitor effect were searched until February 2020. According to the result of this review, cucurbitacin E as a tetracyclic triterpenes compound, has been exhibited cell cycle arrest, anti-inflammatory and anticancer activities

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11

Ponsankar, Athirstam, Kitherian Sahayaraj, Sengottayan Senthil-Nathan, et al. "Toxicity and developmental effect of cucurbitacin E from Citrullus colocynthis L. (Cucurbitales: Cucurbitaceae) against Spodoptera litura Fab. and a non-target earthworm Eisenia fetida Savigny." Environmental Science and Pollution Research 27, no. 19 (2019): 23390–401. http://dx.doi.org/10.1007/s11356-019-04438-1.

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12

Feng, Wei, Yuan Zhou, Ling-Yu Zhou, et al. "Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity." Molecules 24, no. 2 (2019): 331. http://dx.doi.org/10.3390/molecules24020331.

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Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A–E (1–5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1–5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC50 ranging from 5.9 to 33.9 μM compared to Cisplatin.

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13

Singh, Rajendra, Garima Singh, and Ruhi Agrawal. "ASSOCIATION OF APHIDS (HOMOPTERA: APHIDIDAE) WITH THE FLOWERING PLANTS OF NITROGEN-FIXING CLADE OF FABIDS (ANGIOSPERMS: EUDICOTS) IN INDIA." International Journal of Biological Innovations 05, no. 01 (2023): 14–54. http://dx.doi.org/10.46505/ijbi.2023.5102.

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The present checklist deals with the association of aphids with the plants belonging to the four orders of nitrogen-fixing clade of fabids eudicot angiosperms, i.e. Cucurbitales, Fabales, Fagales and Rosales recorded in India. Total 294 species of plants of these orders belonging to 124 genera and 13 families are associated with 239 species of aphids put into 102 genera and 7 subfamilies of aphids. The aphids are related with only two families of Cucurbitales, Begoniaceae and Cucurbitaceae. Single species of Begoniaceae and 21 species of Cucurbitaceae are associated with 2 and 25 species of ap

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14

Nigam, Pragya, Bina Gidwani, Hemant Kumar Dhongde, Anshita Gupta, and Chanchal Deep Kaur. "A Review on Pharmacognostical and Pharmacological Activities of Lagenaria siceraria Species." International Journal of Pharmacology, Phytochemistry and Ethnomedicine 1 (December 2015): 55–64. http://dx.doi.org/10.18052/www.scipress.com/ijppe.1.55.

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The Cucurbitaceae family consists of about 735 species. The present study includes detailed aspects of species of Lagenaria siceraria(Mol.) Standley is a medicinal plant. The plant mainly contains carbohydrates, protein, fats and amino acids. The active constituent of Lagenaria is cucurbitacin, lagenin and various mineral matters. In most of the countries lagenaria has been used as antioxidant, cardiotonic, liver tonic, anti-inflammatory, diuretic, antihepatotoxic, antitumor, anti HIV, anti proliferative agent. Thus, lagenaria posses broad spectrum of pharmacological activities. Moreover, the

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15

Cai, Yuee, Xiefan Fang, Chengwei He, et al. "Cucurbitacins: A Systematic Review of the Phytochemistry and Anticancer Activity." American Journal of Chinese Medicine 43, no. 07 (2015): 1331–50. http://dx.doi.org/10.1142/s0192415x15500755.

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Cucurbitacins are highly oxidized tetracyclic triterpenoids that are widely present in traditional Chinese medicines (Cucurbitaceae family), possess strong anticancer activity, and are divided into 12 classes from A to T with over 200 derivatives. The eight most active cucurbitacin components against cancer are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R. Their mechanisms of action include antiproliferation, inhibition of migration and invasion, proapoptosis, and cell cycle arrest promotion. Cucurbitacins are also found to be the inhibitors of JAK-STAT3, Wnt, PI3K/Akt, and MAPK signali

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16

Kumaraswamy, Latha. "Phytochemical analysis in foamy extract of cucumber (Cucumis sativus L.)." SAARC Journal of Agriculture 20, no. 2 (2022): 145–55. http://dx.doi.org/10.3329/sja.v20i2.63576.

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The metabolite profiling of white foamy substance local white cultivar of Cucumber (Cucumis sativus L.) was performed using HR-LCMS. Prominent compounds with MS spectra, peak list, and compound structure were studied. Which pertains to Cucurbitaceae. The cytotoxic activity was studied on onion root tip squash and microscopic evaluation was done. The principal component analysis (PCA) of the analytical data showed the presence of Triterpenes: Cucurbitacin-C (0.8ppm), Cucurbitacin-E (5.53ppm) and Cardiac glycosides: Gitoxigenin (7.76ppm), Strophanthidin (13.79ppm), and Digitoxigenin (2.13ppm) in

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17

MATTHEWS, MERRAN L., and PETER K. ENDRESS. "Comparative floral structure and systematics in Cucurbitales (Corynocarpaceae, Coriariaceae, Tetramelaceae, Datiscaceae, Begoniaceae, Cucurbitaceae, Anisophylleaceae)." Botanical Journal of the Linnean Society 145, no. 2 (2004): 129–85. http://dx.doi.org/10.1111/j.1095-8339.2003.00281.x.

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18

Mukaila, Yusuf Ola, Abdulwadud Abiodun Ajao, and Abdulwakeel Ayokun-nun Ajao. "A review of the ethnopharmacological significance of Momordica foetida Schumach. (Cucurbitaceae: Cucurbitales)." Egyptian Journal of Basic and Applied Sciences 10, no. 1 (2022): 45–54. http://dx.doi.org/10.1080/2314808x.2022.2149014.

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19

Kurman, Yener, Ilker Kiliccioglu, Asiye U. Dikmen, et al. "Cucurbitacin B and cisplatin induce the cell death pathways in MB49 mouse bladder cancer model." Experimental Biology and Medicine 245, no. 9 (2020): 805–14. http://dx.doi.org/10.1177/1535370220917367.

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Cisplatin-based chemotherapy is the standard regimen for bladder cancer patients, but its effectiveness is limited by high toxicity and the development of drug resistance. It has been reported in many studies that Cucurbitacin B has anti-carcinogenic effects by stimulating apoptosis and autophagy. Here we explored the potential role of cucurbitacin B on MB49 bladder syngeneic mouse tumor model. Single and combined doses of cucurbitacin B and cisplatin were applied to MB49 cell line and the cell viability was determined by Water‐Soluble Tetrazolium Salt‐1 (WST) method. After developing the tumo

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20

Chen, De-Li, Xu-Dong Xu, Rong-Tao Li, et al. "Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities." Molecules 24, no. 16 (2019): 2937. http://dx.doi.org/10.3390/molecules24162937.

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Five new cucurbitane-typetriterpenoid glycosides, named Xuedanoside F–J (1–5), were obtained from the rhizomes of Hemsleya penxianensis (Xue dan), which belongs to the family of Cucurbitaceae. These new compounds were elucidated byspectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS spectra. Additionally, all the isolates were evaluated for cytotoxicity against three human cancer cell lines (Hela, MCF-7, and A-549) with the IC50 ranging from 2.25 to 49.44 µM in vitro with treatment 48 h and showed low cytotoxicity in human normal liver L-02 cells (IC50 > 50 µM). Compound 5 showed the

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21

Kanakasabapathi Pradheep, Soyimchiten, Ganjalagatta Dasaiah Harish, et al. "Updated distribution of seven Trichosanthes L. (Cucurbitales: Cucurbitaceae) taxa in India, along with taxonomic notes." Journal of Threatened Taxa 13, no. 14 (2021): 20143–52. http://dx.doi.org/10.11609/jott.6313.13.14.20143-20152.

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In India, lack of revisionary work in the genus Trichosanthes L. (Cucurbitales: Cucurbitaceae) over the past 38 years had resulted in several taxonomic and nomenclatural issues, which had implications in determining actual distribution status of taxa. Based on field observations, collected specimens, data from various specimens in herbaria and critical study of all the resources available, here we confirm the extended distribution of T. anaimalaiensis Bedd. in the states of Manipur and Nagaland; T. cordata Roxb. in Uttar Pradesh and Bihar; T. cucumerina L. subsp. sublobata (Kundu) K. Pradheep,

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22

Fargo, W. S., P. E. Rensner, E. L. Bonjour, and T. L. Wagner. "Population Dynamics in the Squash Bug (Heteroptera: Coreidae)-Squash Plant (Cucurbitales: Cucurbitaceae) System in Oklahoma1." Journal of Economic Entomology 81, no. 4 (1988): 1073–79. http://dx.doi.org/10.1093/jee/81.4.1073.

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23

Seger, Christoph, Sonja Sturm, Ernst Haslinger, and Hermann Stuppner. "NMR Signal Assignment of 22-Deoxocucurbitacin D and Cucurbitacin D from Ecballium elaterium L. (Cucurbitaceae)." Monatshefte für Chemie - Chemical Monthly 136, no. 9 (2005): 1645–49. http://dx.doi.org/10.1007/s00706-005-0347-2.

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24

Schaefer, Hanno, and Susanne S. Renner. "Phylogenetic relationships in the order Cucurbitales and a new classification of the gourd family (Cucurbitaceae)." TAXON 60, no. 1 (2011): 122–38. http://dx.doi.org/10.1002/tax.601011.

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25

Ma, Jun, Alexander J. Krynitsky, Erich Grundel, and Jeanne I. Rader. "Quantitative Determination of Cucurbitane-Type Triterpenes and Triterpene Glycosides in Dietary Supplements Containing Bitter Melon (Momordica charantia) by HPLC-MS/MS." Journal of AOAC INTERNATIONAL 95, no. 6 (2012): 1597–608. http://dx.doi.org/10.5740/jaoacint.11-511.

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Abstract Momordica charantia L. (Cucurbitaceae), commonly known as bitter melon, is widely cultivated in many tropical and subtropical areas of the world. It is a common food staple; its fruits, leaves, seeds, stems, and roots also have a long history of use in traditional medicine. In the United States, dietary supplements labeled as containing bitter melon can be purchased over-the-counter and from Internet suppliers. Currently, no quantitative analytical method is available for monitoring the content of cucurbitane-type triterpenes and triterpene glycosides, the major constituents of bitter

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26

Hossain, M. Shakhawoat, M. Kamrul Hasan, M. Shoeb, MIR Mamun, N. Nahar, and M Mosihuzzaman. "Isolation and Characterization of Two Cucurbitane Type Triterpenoid Glycocide from 1-Butanol Soluble Part of Momordica charantia Fruit Pulp Juice." Dhaka University Journal of Science 66, no. 2 (2018): 145–49. http://dx.doi.org/10.3329/dujs.v66i2.54560.

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Momordica charantia is a member of the Cucurbitaceae family having diverse biological activities. Two cucurbitane type triterpene glycoside have been isolated from 1-butanol soluble part of clear juice of M. charantia fruit pulp through column chromatography and HPLC. The isolated compounds were characterized as compound MC1 (3β, 7-O-β-glucopyranosyl-25-methoxy cucurbita –5-en-19-al) and compound MC2 (5β, 19-epoxy- 3- O-glucopyranosyl-25 methoxy cucurbita-6, 23-dien) with the help of UV Spectroscopy, Thin Layer Chromatography, IR Spectroscopy, 1H, 13C and dept-135 NMR. The proposed structures

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27

Mabin, Molly Dieterich, Celeste Welty, and Mary M. Gardiner. "Predator richness predicts pest suppression within organic and conventional summer squash (Cucurbita pepo L. Cucurbitales: Cucurbitaceae)." Agriculture, Ecosystems & Environment 287 (January 2020): 106689. http://dx.doi.org/10.1016/j.agee.2019.106689.

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28

Seger, Christoph, Sonja Sturm, Maria-Elisabeth Mair, Ernst P. Ellmerer, and Hermann Stuppner. "1H and13C NMR signal assignment of cucurbitacin derivatives fromCitrullus colocynthis (L.) Schrader andEcballium elaterium L. (Cucurbitaceae)." Magnetic Resonance in Chemistry 43, no. 6 (2005): 489–91. http://dx.doi.org/10.1002/mrc.1570.

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29

Garibaldi, A., D. Bertetti, A. Poli, and M. L. Gullino. "First Report of Black Rot Caused by Phomopsis cucurbitae on Cantaloupe (Cucumis melo) in the Piedmont Region of Northern Italy." Plant Disease 95, no. 10 (2011): 1317. http://dx.doi.org/10.1094/pdis-06-11-0481.

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Cucumis melo L., belonging to the Cucurbitaceae family, is cultivated on more than 23,000 ha in Italy. Cantaloupe (C. melo L. var. cantalupensis Naudin) is the most popular variety. In summer 2010, a previously unknown rot was observed on fruits produced in Italy and marketed in the Piedmont Region of northern Italy. Early symptoms on fruit consisted of irregular, brown, soft, sunken lesions up to 10 cm in diameter. No surface mold was visible and pycnidia were not present. Internally, the decay is adjacent to the sunken area of the fruit's surface and is soft, water soaked, spongy, with a nea

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30

Panda, Siva Prasad, Asit Kumar Sarangi, and Uttam Prasad Panigrahy. "ISOLATION OF CUCURBITACIN-B FROM CUCUMIS CALLOSUS AND ITS HYPOGLYCEMIC EFFECT IN ISOLATED RAT ENTEROCYTES." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 5 (2018): 123. http://dx.doi.org/10.22159/ijpps.2018v10i5.25788.

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Objective: The pericarp of fruits of Cucumis callous (Rottl.) Cogn. (Cucurbitaceae) is traditionally used for curing diabetes, epilepsy, and diarrhea. It has an active compound include Cucurbitacin-B (CuB), which acts as a potent inducer of CYP450 of rat enterocytes. This study was conducted with the aim of elaborating and reconciling our previous finding on the glucose-lowering effect of Cucumis callosus (Rottl.) Cogn. fruits.Methods: In vivo hypoglycemic potential for methanolic pericarp extracts from C callosus (MPCC, 350 mg/kg b.w. p. o), methanolic seed extract of C callosus (MSCC, 250 mg

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Arruda-Gatti, Iara Cintra de, Flávia Augusta Cloclet da Silva, and Maurício Ursi Ventura. "Responses of Diabrotica speciosa to a semiochemical trap characteristics." Brazilian Archives of Biology and Technology 49, no. 6 (2006): 975–80. http://dx.doi.org/10.1590/s1516-89132006000700015.

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Responses of Diabrotica speciosa (Germar) (Coleoptera: Chrysomelidae) to a semiochemical trap characteristics were investigated in the field. The trap consisted of plastic bottles with several perforations (0.5 cm diameter and 2.0 cm distance each other) and containing Lagenaria vulgaris L. (Cucurbitaceae) powder as cucurbitacin (arrestant and phagostimulant) source (0.28%). In common bean fields, transparent green traps caught significantly more males and females beetles than yellow, transparent and white traps. Yellow traps caught significantly more females than white traps. Transparent gree

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32

Liang, Jing, and Dan Chen. "Advances in research on the anticancer mechanism of the natural compound cucurbitacin from Cucurbitaceae plants: a review." Traditional Medicine Research 4, no. 2 (2019): 68–81. http://dx.doi.org/10.53388/tmr20190225102.

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33

Kim, Hyeon Jin, Jung Han Yoon Park, and Jin-Kyung Kim. "Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer." Chemico-Biological Interactions 219 (August 2014): 1–8. http://dx.doi.org/10.1016/j.cbi.2014.05.005.

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34

Schrire, B. D. "CUCURBITACEAE." Bothalia 17, no. 2 (1987): 181. http://dx.doi.org/10.4102/abc.v17i2.1028.

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35

De Winter, B. "CUCURBITACEAE." Bothalia 20, no. 2 (1990): 209–11. http://dx.doi.org/10.4102/abc.v20i2.920.

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36

Bruyns, P. "CUCURBITACEAE." Bothalia 23, no. 2 (1993): 233–35. http://dx.doi.org/10.4102/abc.v23i2.808.

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37

Abdelwahab, Siddig Ibrahim, Loiy Elsir Ahmed Hassan, Amin M. S. Abdul Majid та ін. "Cucurbitacin L 2-O-β-Glucoside Demonstrates Apoptogenesis in Colon Adenocarcinoma Cells (HT-29): Involvement of Reactive Oxygen and Nitrogen Species Regulation". Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/490136.

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Emerging evidence suggests that reactive oxygen (ROS) and nitrogen (RNS) species can contribute to diverse signalling pathways of inflammatory and tumour cells. Cucurbitacins are a group of highly oxygenated triterpenes. Many plants used in folk medicine to treat cancer have been found to contain cucurbitacins displaying potentially important anti-inflammatory actions. The current study was designed to investigate the anti-ROS and -RNS effects of cucurbitacin L 2-O-β-glucoside (CLG) and the role of these signaling factors in the apoptogenic effects of CLG on human colon cancer cells (HT-29). T

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38

Liu, Yang, Heng Yang, Qiang Guo, et al. "Cucurbitacin E Inhibits Huh7 Hepatoma Carcinoma Cell Proliferation and Metastasis via Suppressing MAPKs and JAK/STAT3 Pathways." Molecules 25, no. 3 (2020): 560. http://dx.doi.org/10.3390/molecules25030560.

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Cucurbitacin E (CuE), a highly oxygenated tetracyclic triterpene from Cucurbitaceae, has shown to exhibit potent cytotoxic and anti-proliferative properties against several human cancer cells. However, the underlying effects and mechanisms of CuE regarding hepatocellular carcinoma (HCC) have not been well understood. In the current study, unbiased RNA-sequencing (RNA-seq) and bioinformatics analysis was applied to elucidate the underlying molecular mechanism. CuE could significantly inhibit cell proliferation and migration of Huh7 cells, meanwhile CuE exhibited potent anti-angiogenic activity.

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39

Alafnan, Ahmed, Abdulwahab Alamri, Talib Hussain, and Syed Mohd Danish Rizvi. "Cucurbitacin-B Exerts Anticancer Effects through Instigation of Apoptosis and Cell Cycle Arrest within Human Prostate Cancer PC3 Cells via Downregulating JAK/STAT Signaling Cascade." Pharmaceuticals 15, no. 10 (2022): 1229. http://dx.doi.org/10.3390/ph15101229.

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Cucurbitacin-B (Cur-B) is an analogue triterpenoid belonging to the Cucurbitaceae family. Previous reports have explicitly outlined various biological activities of Cucurbitaceae family members, including the anticancer activity of Cur-B. In the present study, we tried to elucidate the anticancer efficacy of Cur-B against prostate cancer PC3 cells. PC3 cells were exposed to purified Cur-B at 5, 10, 15, 20 and 25 µM for 24. Cur-B exposure reduced cell viability of PC3 cells at 5 µM (p < 0.05), with further reduction with increased Cur-B concentration (15 µM, p < 0.01 and 25 µM, p < 0.0

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Lamont, William J. "Cucurbitaceae 2002." HortScience 39, no. 1 (2004): 203B—203. http://dx.doi.org/10.21273/hortsci.39.1.203b.

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Wan, Jiang, Xiao-Juan Wang, Nan Guo, et al. "Highly Oxygenated Triterpenoids and Diterpenoids from Fructus Rubi (Rubus chingii Hu) and Their NF-kappa B Inhibitory Effects." Molecules 26, no. 7 (2021): 1911. http://dx.doi.org/10.3390/molecules26071911.

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During a phytochemical investigation of the unripe fruits of Rubus chingii Hu (i.e., Fructus Rubi, a traditional Chinese medicine named “Fu-Pen-Zi”), a number of highly oxygenated terpenoids were isolated and characterized. These included nine ursane-type (1, 2, and 4–10), five oleanane-type (3, 11–14), and six cucurbitane-type (15–20) triterpenoids, together with five ent-kaurane-type diterpenoids (21–25). Among them, (4R,5R,8R,9R,10R,14S,17S,18S,19R,20R)-2,19α,23-trihydroxy-3-oxo-urs-1,12-dien-28-oic acid (rubusacid A, 1), (2R*,4S*,5R*,8R*,9R*,10R*,14S*,17S*, 18S*,19R*,20R*)-2α,19α,24-trihyd

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Campbell, Joshua W., Jaret C. Daniels, and James D. Ellis. "Fruit Set and Single Visit Stigma Pollen Deposition by Managed Bumble Bees and Wild Bees in Citrullus lanatus (Cucurbitales: Cucurbitaceae)." Journal of Economic Entomology 111, no. 2 (2018): 989–92. http://dx.doi.org/10.1093/jee/toy008.

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Xu, Ning, Bei-Bei Zhang, Meng-Zhe Yang, et al. "Cucurbitacin B as a Chinese Medicine Monomer Inhibits Cell Proliferation, Invasion, and Migration in Nasopharyngeal Carcinoma." Journal of Nanomaterials 2021 (March 12, 2021): 1–12. http://dx.doi.org/10.1155/2021/5596780.

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Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor in southern China. Cucurbitacin B (CuB) is a tetracyclic triterpene compound isolated from Cucurbitaceae plants which has anti-inflammation and antitumor properties and low toxic side effects. In this study, we use a series of wet experiments and network pharmacology analyses to explore the effects of CuB on cell proliferation, migration, invasion, and apoptosis of highly metastatic 5-8F NPC cells. The findings suggest that CuB inhibits NPC cells in a time- and dose-dependent manner and that cancer migration and invasion abilities

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Packirisamy, Meenatchi, Purushothaman Ayyakkannu, and Maneemegalai Sivaprakasam. "Antidiabetic effect of Coccinia grandis (L.) Voigt (Cucurbitales: Cucurbitaceae) on streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolizing enzymes." Brazilian Journal of Biological Sciences 5, no. 11 (2018): 683–98. http://dx.doi.org/10.21472/bjbs.051107.

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Coccinia grandis (L.) Voigt (Cucurbitales: Cucurbitaceae) is a climbing perennial herb, growing throughout India and it is widely used in the traditional treatment of diabetes. The aim of present study was to evaluate the antidiabetic potential of the mature unripe of Coccinia grandis in streptozotocin (STZ)-induced diabetic rats with special reference to carbohydrate metabolizing enzymes. The optimum dose of Coccinia grandis extract (GCE) was determined by oral glucose tolerance test. The effects of CGE were compared with glibenclamide. Oral administration of Coccinia grandis extract at a con

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Arel-Dubeau, Anne-Marie, Fanny Longpré, Julie Bournival, et al. "Cucurbitacin E Has Neuroprotective Properties and Autophagic Modulating Activities on Dopaminergic Neurons." Oxidative Medicine and Cellular Longevity 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/425496.

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Natural molecules are under intensive study for their potential as preventive and/or adjuvant therapies for neurodegenerative disorders such as Parkinson’s disease (PD). We evaluated the neuroprotective potential of cucurbitacin E (CuE), a tetracyclic triterpenoid phytosterol extracted from theEcballium elaterium(Cucurbitaceae), using a known cellular model of PD, NGF-differentiated PC12. In our postmitotic experimental paradigm, neuronal cells were treated with the parkinsonian toxin 1-methyl-4-phenylpyridinium (MPP+) to provoke significant cellular damage and apoptosis or with the potentN,N-

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Mantzoukas, Spiridon, Eufrosini Daskalaki, Foteini Kitsiou, et al. "Dual Action of Beauveria bassiana (Hypocreales; Cordycipitaceae) Endophytic Stains as Biocontrol Agents against Sucking Pests and Plant Growth Biostimulants on Melon and Strawberry Field Plants." Microorganisms 10, no. 11 (2022): 2306. http://dx.doi.org/10.3390/microorganisms10112306.

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Entomopathogenic fungi (EPF) can colonize plant tissues and serve crops not only as biopesticides but also as biostimulants that promote plant growth and trigger defense mechanisms. In this context, field trials were conducted evaluating two commercial strains of the entomopathogen Beauveria bassiana (Hypocreales: Cordycipitaceae), GHA (Botanigard) and PPRI 5339 (Velifer® ES) and a wild strain (AP0101) isolated from Achaia, Greece. The three strains were investigated in the field for their endophytic effects on melon Cucumis melo (Cucurbitales: Cucurbitaceae) and strawberry Fragaria sp. (Rosal

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Andres, Thomas C. "CUCURBITACEAE WEB SITE." Acta Horticulturae, no. 510 (March 2000): 139–42. http://dx.doi.org/10.17660/actahortic.2000.510.23.

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Kusniawati, Mega Ayu. "Sistematik Review Aktivitas Buah Pare (Momordica charantia L.) Terhadap Target Molekuler Antidiabetes." Jurnal Farmasi Indonesia 18, no. 2 (2021): 141–51. http://dx.doi.org/10.31001/jfi.v18i2.974.

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Diabetes melitus (DM) adalah penyakit kronis yang terjadi baik ketika pankreas tidak menghasilkan cukup insulin, atau ketika tubuh tidak dapat secara efektif menggunakan insulin yang dihasilkannya. Tujuan mengetahui aktivitas buah pare terhadap target molekuler antidiabetes secara literature review. Analisis dan tinjauan pencarian web sistematis dilakukan pada literatur penelitian yang berkaitan dengan buah pare digunakan untuk aktivitas DPP4, PTP1B, α-glukosidase, dan peningkatkan kadar GLUT4. Data dikumpulkan dari beberapa jurnal dengan kriteria inklusi. Data diekstraksi dan data sinte

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Liu, Yafei, Huinan Xu, Huasen Wang, and Shengjun Feng. "Research Progress in Leaf Related Molecular Breeding of Cucurbitaceae." Agronomy 12, no. 11 (2022): 2908. http://dx.doi.org/10.3390/agronomy12112908.

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Cucurbitaceae crops play an important role in agricultural production, and they are a primary source of vegetables and fruits for daily needs. The cultivation of cucurbit varieties with excellent agronomic characters has attracted much attention in recent years. As the main source energy organ of Cucurbitaceae, the development of leaves is closely related to yield and environmental response. In this paper, the main research achievements on leaf development of Cucurbitaceae plants were summarized, and the origin, genetic research, gene mapping, and effects on the agronomic and economic characte

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Fisher, Kelsey E., J. Lindsey Flexner, and Charles E. Mason. "Plant Preferences of Z-Pheromone Race Ostrinia nubilalis (Lepidoptera: Crambidae) Based on Leaf Tissue Consumption Rates." Journal of Economic Entomology 113, no. 3 (2020): 1563–67. http://dx.doi.org/10.1093/jee/toaa047.

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Abstract European corn borer, Ostrinia nubilalis Hübner (Lepidoptera: Crambidae), has been present in the United States for over 100 yr and documented on &gt;200 plant species, including economically valuable crops. The reported preferred host of O. nubilalis is corn, Zea mays L. (Cyperales: Poaceae), although it is considered to be a generalist agricultural pest. Life cycles of the two pheromone races, E and Z, align with the seasonality of different agricultural plants. Since the introduction of Bt corn in 1996, overall O. nubilalis presence has declined and suggests that alternative cro

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