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Journal articles on the topic 'Cucurbitacina E'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Mikami, Adriana Yatie, and Maurício Ursi Ventura. "Isca amilácea de cucurbitacina (Lagenaria vulgaris L.) promove maior eficiência do inseticida carbaril no controle de Diabrotica speciosa, em laboratório." Ciência Rural 38, no. 8 (2008): 2119–23. http://dx.doi.org/10.1590/s0103-84782008000800005.

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Diabrotica speciosa (Germar, 1824) (Coleoptera: Chrysomelidae: Galerucinae) é uma importante praga polífaga na América Latina. Seu controle é realizado com inseticidas sintéticos, o que causa problemas ambientais. Desse modo, o objetivo do trabalho foi avaliar a isca amilácea de cucurbitacina (Lagenaria vulgaris L.) associada ao inseticida carbaril no controle de D. speciosa em laboratório. Foram realizados testes de múltipla escolha pareados e confinamento com insetos adultos. Os tratamentos foram: isca amilácea de cucurbitacina, isca + carbaril, apenas carbaril e a testemunha (água destilada

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2

Alka Hande, Akhilesh Agrawal, Archana Sonone, Amol Gadbail, Madhuri Gawande, and Swati Patil. "Cucurbitacin: As a candidate against Cytokine Storm in Severe COVID-19 Infection." International Journal of Research in Pharmaceutical Sciences 11, SPL1 (2020): 928–30. http://dx.doi.org/10.26452/ijrps.v11ispl1.3164.

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The severity of SARS-CoV-2 infection is marked by elevated cytokines and chemokines levels like interleukin 6 (IL-6), interferon-gamma (IFN-γ), tumour necrosis factor (TNF), IL-2 and monocyte chemotactic protein 1. This hyperactive pro-inflammatory response identified as the Cytokine Storm (CS) complicates the disease leading to extensive damage of the host tissue, Acute Respiratory Distress Syndrome (ARDS), which further result in multiple organ failures. CS is very critical for the disease progression and is responsible for high death rate in an infected patient. Accordingly, various therape

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3

Lee, Dhong Hyun, Gabriela B. Iwanski, and Nils H. Thoennissen. "Cucurbitacin: Ancient Compound Shedding New Light on Cancer Treatment." Scientific World JOURNAL 10 (2010): 413–18. http://dx.doi.org/10.1100/tsw.2010.44.

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Cucurbitacins and their derivatives are triterpenoids found in medicinal plants known for their diverse pharmacological and biological activities, including anticancer effects, throughout human history. Although initial attention to cucurbitacin as a potential anticancer drug withered for decades, recent discoveries showing that cucurbitacin is a strong STAT3 (Signal Transducers and Activators of Transcription-3) inhibitor have reclaimed the attention of the drug industry one more time. There is increasing evidence showing that some cucurbitacins not only inhibit the JAK-STAT pathway, but also

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4

Ku, Jin Mo, Se Hyang Hong, Hyo In Kim, et al. "Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling." European Journal of Inflammation 16 (January 1, 2018): 1721727X1775180. http://dx.doi.org/10.1177/1721727x17751809.

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Cucurbitacins are triterpenoids commonly found in Cucurbitaceae and Cruciferae and have long been used in traditional medicine. Cucurbitacins demonstrate anti-inflammatory and anti-cancer activities. We investigated whether cucurbitacin D affects viability in breast cancer cells and its mechanism of action. An MTT assay was used to measure the viability of breast cancer cells. Western blot analysis was used to measure the expression of various modulators, such as p-p53, p-Stat3, p-Akt, and p-NF-κB. Doxorubicin and cucurbitacin D affected the viability of MCF7, MDA-MB-231, and SKBR3 cells. Cucu

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5

Cai, Yuee, Xiefan Fang, Chengwei He, et al. "Cucurbitacins: A Systematic Review of the Phytochemistry and Anticancer Activity." American Journal of Chinese Medicine 43, no. 07 (2015): 1331–50. http://dx.doi.org/10.1142/s0192415x15500755.

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Cucurbitacins are highly oxidized tetracyclic triterpenoids that are widely present in traditional Chinese medicines (Cucurbitaceae family), possess strong anticancer activity, and are divided into 12 classes from A to T with over 200 derivatives. The eight most active cucurbitacin components against cancer are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R. Their mechanisms of action include antiproliferation, inhibition of migration and invasion, proapoptosis, and cell cycle arrest promotion. Cucurbitacins are also found to be the inhibitors of JAK-STAT3, Wnt, PI3K/Akt, and MAPK signali

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6

Abdel Halim, Osama B., El-Sayed M. Marawan, Ali A. El-Gamal, and Mona G. Zaghloul. "Socotroside, a New Pentacyclic Cucurbitane Glycoside from Dendrosicyos socotrana." Zeitschrift für Naturforschung B 63, no. 12 (2008): 1415–20. http://dx.doi.org/10.1515/znb-2008-1212.

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Phytochemical investigation of the ethyl acetate extract of the stem of Dendrosicyos socotrana Balf. f. resulted in the isolation of a new pentacyclic cucurbitane glycoside Socotroside, in addition to the three known cucurbitacins, dihydrocucurbitacin D, dihydrocucurbitacin F and cucurbitacin G. The structures of the isolated compounds were established on the basis of their spectral data. The isolated cucurbitacin aglycones showed marked cytotoxic activity.

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7

Tosun, Emir, and Ahmet Baysar. "Simultaneous isolation and purification of cucurbitacin D and I from Ecballium elaterium (l.) A. Rich fruit juice." Macedonian Journal of Chemistry and Chemical Engineering 38, no. 2 (2019): 171. http://dx.doi.org/10.20450/mjcce.2019.1648.

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The objective of this study was to develop a rapid, economic, and efficient method for simultaneous selective isolation, separation, and purification of cucurbitacin D and I from Ecballium elaterium (L.) A. Rich fruit juice via reversed-phase flash chromatography combined with HPLC. The chloroform extract of the fruit juice was fractionated with flash chromatography using a chloroform, acetone and methanol solvent combination at a 5 ml/min flow rate. Then, a validated HPLC method was utilized for purification of the two targeted cucurbitacins. Cucurbitacin D and I were collected automatically

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8

Mu, Shicheng, Jiao Li, Cui Liu, et al. "Effective Glycosylation of Cucurbitacin Mediated by UDP-Glycosyltransferase UGT74AC1 and Molecular Dynamics Exploration of Its Substrate Binding Conformations." Catalysts 10, no. 12 (2020): 1466. http://dx.doi.org/10.3390/catal10121466.

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Cucurbitacins, a group of diverse tetracyclic triterpenes, display a variety of biological effects. Glycosylation mediated by glycosyltransferases (UGTs) plays a vital role in structural and functional diversity of natural products and influences their biological activities. In this study, GT-SM, a mutant of UGT74AC1 from Siraitia grosvenorii, was chosen as a potential catalyst in glycosylation of cucurbitacins, and its optimal pH, temperature, and divalent metal ions were detected. This enzyme showed high activity (kcat/Km, 120 s−1 µM−1) toward cucurbitacin F 25-O-acetate (CA-F25) and only pr

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9

Wang, Xiaojuan, Mine Tanaka, Herbenya Silva Peixoto, and Michael Wink. "Cucurbitacins: elucidation of their interactions with the cytoskeleton." PeerJ 5 (May 30, 2017): e3357. http://dx.doi.org/10.7717/peerj.3357.

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Cucurbitacins, a class of toxic tetracyclic triterpenoids in Cucurbitaceae, modulate many molecular targets. Here we investigated the interactions of cucurbitacin B, E and I with cytoskeletal proteins such as microtubule and actin filaments. The effects of cucurbitacin B, E and I on microtubules and actin filaments were studied in living cells (Hela and U2OS) and in vitro using GFP markers, immunofluorescence staining and in vitro tubulin polymerization assay. Cucurbitacin B, E and I apparently affected microtubule structures in living cells and cucurbitacin E inhibited tubulin polymerization

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10

Cheng, Fengdong, Hongwei Wang, Alfonso Suarez, Pedro Horna, Said Sebti, and Eduardo M. Sotomayor. "Cucurbitacins, a Family of Natural Compounds That Effectively Disrupt Stat3 Signaling in Antigen-Presenting Cells (APCs) Are Promising Agents To Overcome Tumor-Induced CD4+ T-Cell Tolerance." Blood 106, no. 11 (2005): 1485. http://dx.doi.org/10.1182/blood.v106.11.1485.1485.

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Abstract Signal transducer and activator of transcription 3 (Stat3) is a key mediator of several cytokines and growth factors signaling pathways. On myeloid cells, activation of Stat3 to its phosphorylated form (pStat3) has been shown to negatively regulate inflammatory responses. Recently, we have unambiguously demonstrated that Stat3 signaling in APCs also play a central role in the decision leading to immune activation versus immune tolerance of antigen-specific T-cells1. In spite of these advances, there is however a paucity of therapeutic strategies targeting this signaling pathway in imm

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11

Ramezani, Moazzameh, Melika Hasani, Fatemeh Ramezani, and Mahmood Karimi Abdolmaleki. "Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities." Pharmaceutical Sciences 27, no. 1 (2020): 1–13. http://dx.doi.org/10.34172/ps.2020.66.

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For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed, Scopus, and Google Scholar. The keywords of cucurbitacin, cucumber anticancer therapy, cytotoxic effects, chemotherapy, and inhibitor effect were searched until February 2020. According to the result of this review, cucurbitacin E as a tetracyclic triterpenes compound, has been exhibited cell cycle arrest, anti-inflammatory and anticancer activities

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12

Delporte, Carla, Orlando Muñozb, Javier Rojas, et al. "Pharmaco-Toxicological Study of Kageneckia oblonga, Rosaceae." Zeitschrift für Naturforschung C 57, no. 1-2 (2002): 100–108. http://dx.doi.org/10.1515/znc-2002-1-218.

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The probable antipyretic, antiinflammatory, analgesic and antioxidant properties of Kageneckia oblonga, Rosaceae, were investigated and the major compounds of its active extracts were isolated. The study comprised the acute toxicity of the extracts of global methanol, hexane, dichloromethane and methanol. The cytotoxicity of global methanol extract was studied in three tumoral cell lines. All the extracts exhibited the pharmacological activities under study. Methanol and dichloromethane were the most toxic extracts. From the global methanol extract, isolations were performed of prunasin, 23,24

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13

Muñoz, Orlando, Carla Delporte, Nadine Backhouse, et al. "A New Cucurbitacin Glycoside from Kageneckia oblonga (Rosaceae)." Zeitschrift für Naturforschung C 55, no. 3-4 (2000): 141–45. http://dx.doi.org/10.1515/znc-2000-3-403.

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Abstract A novel cucurbitacin glycoside has been isolated from aerial parts of Kageneckia oblonga R. et P. and shown to be 3β-(β-D-glucosyloxy)-16α,23α-epoxycucurbita-5,24-dien-11-one. The structure was established by usual spectroscopic and two-dimensional (2D ) NMR techniques. This compound has found to be nontoxic when tested in-vivo cell culture assays. In previous investigations we reported 23,24-dihydrocucurbitacin F and prunasine. This was the first report on cucurbitacins from the genus Kageneckia (Rosaceae).

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14

Vogler, Lars, Andreas Merkenschlager, and Matthias Karl Bernhard. "Cucurbitacin-Vergiftung durch Kürbisse – ein Fallbericht." Kinder- und Jugendmedizin 03, no. 05 (2003): 199–200. http://dx.doi.org/10.1055/s-0037-1617795.

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ZusammenfassungKürbisgewächse können giftige Cucurbitacine enthalten. Bei Cucurbitacinen handelt es sich chemisch um tetrazyklische Triterpene, die in Zier- und Wildkürbissen vorkommen. Durch Kreuzungen oder Rückmutationen können kultivierte Kürbisgewächse erneut die giftige Substanz bilden. Die Vergiftung verursacht vor allem durch Schleimhautreizung akute gastrointestinale Symptome wie Erbrechen, Speichelfluss und Durchfall. Einzelne Todesfälle durch Kreislaufversagen bei Kindern und älteren Menschen wurden beschrieben. Die Therapie erfolgt symptomatisch. Wir berichten von einem 8-jährigen M

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15

Abdelwahab, Siddig Ibrahim, Loiy Elsir Ahmed Hassan, Amin M. S. Abdul Majid та ін. "Cucurbitacin L 2-O-β-Glucoside Demonstrates Apoptogenesis in Colon Adenocarcinoma Cells (HT-29): Involvement of Reactive Oxygen and Nitrogen Species Regulation". Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/490136.

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Emerging evidence suggests that reactive oxygen (ROS) and nitrogen (RNS) species can contribute to diverse signalling pathways of inflammatory and tumour cells. Cucurbitacins are a group of highly oxygenated triterpenes. Many plants used in folk medicine to treat cancer have been found to contain cucurbitacins displaying potentially important anti-inflammatory actions. The current study was designed to investigate the anti-ROS and -RNS effects of cucurbitacin L 2-O-β-glucoside (CLG) and the role of these signaling factors in the apoptogenic effects of CLG on human colon cancer cells (HT-29). T

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16

DINAN, Laurence, Pensri WHITING, Jean-Pierre GIRAULT, et al. "Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor." Biochemical Journal 327, no. 3 (1997): 643–50. http://dx.doi.org/10.1042/bj3270643.

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Two triterpenoids, cucurbitacins B and D, have been isolated from seeds of Iberis umbellata (Cruciferae) and shown to be responsible for the antagonistic activity of a methanolic extract of this species in preventing the 20-hydroxyecdysone (20E)-induced morphological changes in the Drosophila melanogaster BII permanent cell line. With a 20E concentration of 50 nM, cucurbitacins B and D give 50% responses at 1.5 and 10 μM respectively. Both cucurbitacins are able to displace specifically bound radiolabelled 25-deoxy-20-hydroxyecdysone (ponasterone A) from a cell-free preparation of the BII cell

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17

Yıilmaz, Kadir, Fuat Karakuş, Ergül Eyol, Emir Tosun, İsmet Yıilmaz, and Songül Ünüvar. "Cytotoxic Effects of Cucurbitacin I and Ecballium elaterium on Breast Cancer Cells." Natural Product Communications 13, no. 11 (2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301108.

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The objective of this study was to investigate the inhibitory effect of cucurbitacin I (CuI) and Ecballium elaterium L. (fruit juice and chloroform extract) on breast cancer cells (MCF-7 and MDA-MB-231). The CuI content of E. elaterium fruit juice and chloroform extract was quantified using high performance liquid chromatography. The cytotoxic effects of the fruit juice, chloroform extract and CuI were determined by MTT, wound healing and colony formation assays; all had an anti-proliferative activity on the breast cancer cells. Clarifying the mechanisms of cucurbitacins will enable the identi

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18

Shang, Yi, Yongshuo Ma, Yuan Zhou, et al. "Biosynthesis, regulation, and domestication of bitterness in cucumber." Science 346, no. 6213 (2014): 1084–88. http://dx.doi.org/10.1126/science.1259215.

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Cucurbitacins are triterpenoids that confer a bitter taste in cucurbits such as cucumber, melon, watermelon, squash, and pumpkin. These compounds discourage most pests on the plant and have also been shown to have antitumor properties. With genomics and biochemistry, we identified nine cucumber genes in the pathway for biosynthesis of cucurbitacin C and elucidated four catalytic steps. We discovered transcription factors Bl (Bitter leaf) and Bt (Bitter fruit) that regulate this pathway in leaves and fruits, respectively. Traces in genomic signatures indicated that selection imposed on Bt durin

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Nogueira Fernandes Dantas, Ivana, Gardenia Carmen Militaõ Gadelha, Davina Camelo Chaves, et al. "Studies on the Cytotoxicity of Cucurbitacins Isolated from Cayaponia racemosa (Cucurbitaceae)." Zeitschrift für Naturforschung C 61, no. 9-10 (2006): 643–46. http://dx.doi.org/10.1515/znc-2006-9-1005.

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AbstractThe cytotoxic potential of three cucurbitacins, 2,3,16,20(R),25-pentahydroxy-11,22-dioxocucurbita- 5-en (cucurbitacin P, 1), 2,3,16,20(R),25-pentahydroxy-22-oxocucurbita-5-en (2) and 2,3,16,20(R),25-pentahydroxy-22-oxocucurbita-5,23(E)-diene (deacetylpicracin, 3), obtained from Cayaponia racemosa was evaluated as their ability to induce brine shrimp lethality, to inhibit the development of sea urchin eggs and tumor cell proliferation, and to lysis mouse erythrocytes. Compounds 1 and 2 were highly toxic with LC50 of (29.6 ± 9.1) (56.8) and (38.8 ± 3.0) (76.6) μg/mL (μм), respectively, w

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Yang, Dong Kwon, and Shang-Jin Kim. "Cucurbitacin I Protects H9c2 Cardiomyoblasts against H2O2-Induced Oxidative Stress via Protection of Mitochondrial Dysfunction." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/3016382.

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Cucurbitacin I, a triterpenoid natural compound, exhibits various pharmacological properties, including anticancer, anti-inflammatory, and hepatoprotective properties. However, antioxidant effects of cucurbitacin I in cardiac cells are currently unknown. In the present study, we assessed the preventive effects of cucurbitacin I against the oxidative stress in H9c2 cardiomyoblasts. To evaluate antioxidant effects of cucurbitacin I in H9c2 cardiomyoblasts, H2O2-treated H9c2 cells were pretreated with various concentrations of the cucurbitacin I. Cell viability, reactive oxygen species (ROS) prod

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Dube, Zakheleni P., Phatu W. Mashela, and Dirk de Waele. "Sensitivity of Meloidogyne incognita second-stage juvenile hatch, motility and viability to pure cucurbitacins and cucurbitacin-containing phytonematicides." South African Journal of Plant and Soil 36, no. 1 (2018): 29–32. http://dx.doi.org/10.1080/02571862.2018.1464220.

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22

Duangmano, Suwit, Phorntip Sae-lim, Apichart Suksamrarn, Pimpicha Patmasiriwat, and Frederick E. Domann. "Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest." Journal of Oncology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/601682.

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Purpose. To explore the effects of cucurbitacin B on the radiation survival of human breast cancer cells and to elucidate the cellular mechanism of radiosensitization if any.Materials and Methods. Human breast carcinoma cell lines were treated with cucurbitacin B before irradiation with 0–10 Gy ofC137sgamma rays. The effect of cucurbitacin B on cell-survival following irradiation was evaluated by colony-forming assay. Cell cycle distributions were investigated using flow cytometry. Real-time PCR and western blots were performed to investigate the expression of cell cycle checkpoints.Results.Cu

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Ferguson, J. E., and R. L. Metcalf. "Cucurbitacins." Journal of Chemical Ecology 11, no. 3 (1985): 311–18. http://dx.doi.org/10.1007/bf01411417.

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Hussain, Hidayat, Ivan R. Green, Muhammad Saleem, Khanzadi F. Khattak, Muhammad Irshad, and Maroof Ali. "Cucurbitacins as Anticancer Agents: A Patent Review." Recent Patents on Anti-Cancer Drug Discovery 14, no. 2 (2019): 133–43. http://dx.doi.org/10.2174/1574892813666181119123035.

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Background: Cucurbitacins belong to a group of tetracyclic triterpenoids that display a wide range of biological effects. In the past, numerous cucurbitacins have been isolated from natural sources and many active compounds have been synthesized using the privileged scaffold in order to enhance its cytotoxic effects. Objective: his review covers patents on the therapeutic effects of natural cucurbitacins and their synthetic analogs published during the past decade. By far, the majority of patents published are related to cancer and Structure-Activity Relationships (SAR) of these compounds are

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Wu, Chuanhong, Jiaolin Bao, Chengwei He, Jinjian Lu, and Xiuping Chen. "Cucurbitacin B inhibits proliferation, induces G2/M cycle arrest and autophagy without affecting apoptosis but enhances MTT reduction in PC12 cells." Bangladesh Journal of Pharmacology 11, no. 1 (2015): 110. http://dx.doi.org/10.3329/bjp.v11i1.23791.

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<p class="Abstract">In the present study, the effect of cucurbitacin B (a natural product with anti-cancer effect) was studied on PC12 cells. It significantly reduced the cell number, changed cell morphology and inhibited colony formation while MTT results showed increased cell viability. Cucurbitacin B treatment increased activity of succinode hydrogenase. No alteration in the integrity of mem-brane, the release of lactic dehydrogenase, the mitochondrial membrane potential, and the expression of apoptotic proteins suggested that cucurbitacin B did not induce apoptosis. The cell cycle wa

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Zhang, Zhe, Ying Shen, Jian Wu, and Lin Cai. "Enhanced antitumor activity of cucurbitacin B combined with cerulenin in osteosarcoma." Bangladesh Journal of Pharmacology 10, no. 4 (2015): 956. http://dx.doi.org/10.3329/bjp.v10i4.24601.

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<p class="Abstract">In the present study, the effect of cucurbitacin B and cerulenin combination on osteosarcoma was investigated to develop an effective treatment regimen. The IC<sub>50 </sub>values of cerulenin and cucurbitacin B combination in the proportion of 1:1, 1:2 and 2:1 were 3.5, 7.2 and 8.6 μg/mL, respectively. The combination index (CI) values of &lt;0.95 for inhibition of growth and &lt;0.93 for inhibition of SENP5 expression clearly indicated synergism between the two. The Q-value for combination of 1 μg/mL cerulenin and 1 μg/mL cucurbitacin B was 1.2.

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Klungsaeng, Sirinapha, Veerapol Kukongviriyapan, Auemduan Prawan, Sarinya Kongpetch, and Laddawan Senggunprai. "Targeted Modulation of FAK/PI3K/PDK1/AKT and FAK/p53 Pathways by Cucurbitacin B for the Antiproliferation Effect Against Human Cholangiocarcinoma Cells." American Journal of Chinese Medicine 48, no. 06 (2020): 1475–89. http://dx.doi.org/10.1142/s0192415x2050072x.

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Inadequate responses to traditional chemotherapeutic agents in cholangiocarcinoma (CCA) emphasize a requirement for new effective compounds for the treatment of this malignancy. This study aimed to investigate the antiproliferative property of cucurbitacin B on KKU-100 CCA cells. The determination of underlying molecular mechanisms was also carried out. The results revealed that cucurbitacin B suppressed growth and replicative ability to form colonies of CCA cells, suggesting the antiproliferative effect of this compound against the cells. Flow cytometry analysis demonstrated that the interfer

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Zhong, J., Z. Liu, S. Liu, and J. Zhao. "Inhibition of SENP5 by Cucurbitacin B Suppresses Cell Growth and Promotes Apoptosis in Osteosarcoma Cells." Tropical Journal of Pharmaceutical Research 14, no. 9 (2015): 1573–79. http://dx.doi.org/10.4314/tjpr.v14i9.5.

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Purpose: To investigate the effect of cucurbitacin B on the expression of SUMO-specific proteases (SENP5).Methods: Effect of cucurbitacin B (10-50 mg/mL) on viability of U2OS and Saos-2 cells was determined in a plate reader by recording absorbance at 570 nm. In Western blot analysis, bicinconinic acid (BCA) method was used to determine protein concentration. Flow cytometry was employed to measure DNA content.Results: Ccucurbitacin B treatment inhibits the expression of SENP5 in U2OS and Saos-2 osteosarcoma cells in a dose- and time-dependent manner. Significant inhibition (p = 0.005) of SENP5

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Kurman, Yener, Ilker Kiliccioglu, Asiye U. Dikmen, et al. "Cucurbitacin B and cisplatin induce the cell death pathways in MB49 mouse bladder cancer model." Experimental Biology and Medicine 245, no. 9 (2020): 805–14. http://dx.doi.org/10.1177/1535370220917367.

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Cisplatin-based chemotherapy is the standard regimen for bladder cancer patients, but its effectiveness is limited by high toxicity and the development of drug resistance. It has been reported in many studies that Cucurbitacin B has anti-carcinogenic effects by stimulating apoptosis and autophagy. Here we explored the potential role of cucurbitacin B on MB49 bladder syngeneic mouse tumor model. Single and combined doses of cucurbitacin B and cisplatin were applied to MB49 cell line and the cell viability was determined by Water‐Soluble Tetrazolium Salt‐1 (WST) method. After developing the tumo

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Dittharot, Kanthanadon, Sumana Dakeng, Parichat Suebsakwong, Apichart Suksamrarn, Pimpicha Patmasiriwat, and Moltira Promkan. "Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells." Planta Medica 85, no. 05 (2018): 370–78. http://dx.doi.org/10.1055/a-0791-1591.

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AbstractBreast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations. Recent studies revealed that abnormal gene expression induced by epigenetic changes including aberrant promoter methylation plays a critical role in human breast carcinogenesis. Cucurbitacin B has antiproliferative activity against various human breast cancer cells, but the molecular mechanism is not completely understood. In this study, we explore the influence of cucurbitacin B from Trichosanthes cucumerina on the methylation status at the promoter of oncogenes c-Myc, cycl

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Huang, Wen-Wen, Jai-Sing Yang, Meng-Wei Lin, et al. "Cucurbitacin E Induces G2/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes ApoptosisviaFas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/952762.

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Cucurbitacin E, a tetracyclic triterpenes compound extracted from cucurbitaceous plants, has been shown to exhibit anticancer and anti-inflammatory activities. The purpose of this study was to elucidate whether cucurbitacin E promotes cell cycle arrest and induces apoptosis in T24 cells and further to explore the underlying molecular mechanisms. The effects of cucurbitacin E on T24 cell's growth and accompanied morphological changes were examined by MTT assay and a phase-contrast microscope. DNA content, mitochondrial membrane potential (ΔΨm) and annexin V/PI staining were determined by flow c

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Kadhim, Haider M., Maha N. Hamad, and Yasir M. Kadhim. "Isolation and Identification of two Cucurbitacins B and E, and Detection of Phytosterols in Cucurbita pepo L. var. pepo (Pumpkin) Leaves Extract." International Journal of Drug Delivery Technology 10, no. 03 (2020): 369–73. http://dx.doi.org/10.25258/ijddt.10.3.11.

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Cucurbita pepo (pumpkin), a Cucurbitaceae membered plant, is considered one of the oldest cultivated plants; it has been cultivated about 7,000 to 5,500 BC. Traditionally, C. pepo is cultivated from very close to sea level in semi-dry climates, to others, which are cultivated at altitudes greater than 2,000 meters. Ethnopharmacological studies show that C. pepo is used in many countries for treating several diseases, e.g., as an anti-inflammatory, analgesic, urinary disorders, anti-ulcer, anti-diabetic, and anti-oxidant. C. pepo leaves extracted with 90% methanol by maceration with continuous

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Kim, Si Hyoung, Jun Goo Kang, Chul Sik Kim, et al. "Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells." Tumor Biology 39, no. 2 (2017): 101042831769225. http://dx.doi.org/10.1177/1010428317692252.

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In this study, the combined effect of doxorubicin with cucurbitacin B on survival of anaplastic thyroid carcinoma cells was evaluated. For experiments, 8505C and CAL62 human anaplastic thyroid carcinoma cells were used. Cell viability, the percentage of viable cells, and cytotoxic activity were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, multiplexed cytotoxicity assay, and cytotoxicity assay, respectively. Reactive oxygen species production was measured. In experiments, doxorubicin and cucurbitacin B reduced cell viability in a dose- and time-dependent ma

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Yang, Peiquan, Songyu Liu, Zhihong Cao, Wenjin Chang, and Chun-tao Che. "Cucurbitacin Contents in Hemsleya dolichocarpa." American Journal of Chinese Medicine 19, no. 01 (1991): 51–56. http://dx.doi.org/10.1142/s0192415x91000077.

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Hemsleya dolichocarpa was studied for its cucurbitacin contents during growing period. A colorimetric method was used to determine the total cucurbitacin levels, and a TLC densitometric assay was employed for estimating dihydrocucurbitacin F and its acetate, two active principles in Hemsleya plants. Cucurbitacin contents rise progressively from May to November; the month of November is thus the most desirable time for harvesting plant materials for medicinal uses. It was noticed that the spoiled plant samples gave an intense color reaction while dihydrocucurbitacin F and its acetate levels wer

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Ge, Weizhi, Xinyi Chen, Fangzhi Han, et al. "Synthesis of Cucurbitacin B Derivatives as Potential Anti-Hepatocellular Carcinoma Agents." Molecules 23, no. 12 (2018): 3345. http://dx.doi.org/10.3390/molecules23123345.

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Cucurbitacin B shows potent activity against tumor cells, but its high toxicity limits its application in the clinic. A series of cucurbitacin B derivatives was synthesized and evaluated for their anti-hepatocellular carcinoma (HCC) activities against the HepG-2 cell line. These compounds were also tested for their toxicity against the L-O2 normal cell line. The compound with the most potential, 10b, exhibited potent activity against the HepG-2 cell line with an IC50 value of 0.63 μM. Moreover, compound 10b showed the highest TI value (4.71), which is a 14.7-fold improvement compared to its pa

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Chang, Yun-Hee, Jung-Ha Choo, So-Young Lee, et al. "Inhibition of Melanogenesis by Cucurbitacin B from Cucumis sativus L." Journal of the Society of Cosmetic Scientists of Korea 40, no. 4 (2014): 403–12. http://dx.doi.org/10.15230/scsk.2014.40.4.403.

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Shadung, Kagiso Given, Phatu William Mashela, and Maboko Samuel Mphosi. "Suitable Drying Temperature for Preserving Cucurbitacins in Fruit of Wild Cucumber and Wild Watermelon." HortTechnology 26, no. 6 (2016): 816–19. http://dx.doi.org/10.21273/horttech03400-16.

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The thermostable cucurbitacin A and B from mature fruit of wild cucumber (Cucumis myriocarpus) and wild watermelon (Cucumis africanus), respectively, are used in product development for various industries. Mature fruit from wild cucumber and wild watermelon suffer from high incidents of postharvest decays. Drying fruit at the recommended temperatures of 30 to 40 °C for medicinal plants resulted in molds developing on the material, with optimum temperature to prevent decays being at 52 °C. The influence of 52 °C and higher temperatures on active ingredients in the two fruit had not been documen

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Jung, Carlo, Benjamin Steuber, and Harald Schwörer. "Lebensmittelvergiftung durch Cucurbitacine." DMW - Deutsche Medizinische Wochenschrift 145, no. 14 (2020): 988–90. http://dx.doi.org/10.1055/a-1163-9741.

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Zusammenfassung Anamnese und klinischer Befund Die 66-jährige Patientin ist wegen einer akuten Lebensmittelvergiftung nach Ingestion von bitteren Zucchini in die Notaufnahme mit Tachykardie, Hypotonie und Somnolenz sowie Exsikkose, Übelkeit, Erbrechen und Hämatochezie eingewiesen worden. Untersuchungen und Diagnose Auffällig waren eine Leukozytose sowie sonografisch eine Kolitis. Die Diagnose einer akuten Lebensmittelvergiftung mit hämorrhagischer Kolitis, ausgelöst durch Cucurbitacin – haltige Zucchini, wurde gestellt. Therapie und Verlauf Nach intravenöser Volumensubstitution stabilisierte s

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Hiwatari, Mitsuteru, Kentaro Watanabe, Yasuo Kubota, Shunsuke Kimura, and Junko Takita. "Identification of Novel Pathways and Small Molecules Able to Down Regulate Oncogenes Expression By Compounds Screening Approaches in Acute Leukemia and Neuroblastoma Cells." Blood 132, Supplement 1 (2018): 2214. http://dx.doi.org/10.1182/blood-2018-99-111090.

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Abstract Targeting anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase initially identified as a potent oncogenic driver in anaplastic large-cell lymphoma (ALCL) in the form of nucleophosmin (NPM)-ALK fusion protein, using tyrosine kinase inhibitors has shown to be a promising therapeutic approach for ALK-expressing tumors. However, resistance to ALK inhibitors is a ubiquitous problem in ALK-expressing cell lines as well as treated patients. Amplified ALK or mutated ALK was identified in ~14% of neuroblastomas (NB), the most common and aggressive childhood malignancy, and phase I tria

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Galindo, Antonio, Nelson Villegas, and Horacio Mansilla. "Cucurbitacins From Bryonia Verrucosa. Isomerization of 2-Hydroxy-3-Keto-Cucurbitacins." Natural Product Letters 13, no. 4 (1999): 285–92. http://dx.doi.org/10.1080/10575639908048799.

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Bhandari, Pamita, Neeraj Kumar, Bikram Singh, and Vijay K. Kaul. "Cucurbitacins from Bacopa monnieri☆." Phytochemistry 68, no. 9 (2007): 1248–54. http://dx.doi.org/10.1016/j.phytochem.2007.03.013.

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Sallam, Amal A., Yukio Hitotsuyanagi, El-Sayed S. Mansour, et al. "Cucurbitacins from Bryonia cretica." Phytochemistry Letters 3, no. 3 (2010): 117–21. http://dx.doi.org/10.1016/j.phytol.2010.02.009.

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Hylands, Peter J., and Mostafa S. Magd. "Cucurbitacins from Acanthosicyos horridus." Phytochemistry 25, no. 7 (1986): 1681–84. http://dx.doi.org/10.1016/s0031-9422(00)81235-2.

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Gamlath, Chandra B., A. A. Leslie Gunatilaka, Khisal A. Alvi, Atta-ur-Rahman, and Sinnathamby Balasubramaniam. "Cucurbitacins of Colocynthis vulgaris." Phytochemistry 27, no. 10 (1988): 3225–29. http://dx.doi.org/10.1016/0031-9422(88)80031-1.

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Stuppner, Hermann, Ernst P. Müller, and Hildebert Wagner. "Cucurbitacins from Picrorhiza kurrooa." Phytochemistry 30, no. 1 (1991): 305–10. http://dx.doi.org/10.1016/0031-9422(91)84143-g.

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Schenkel, Eloir Paulo, Mareni Rocha Farias, Ralf Mayer, Eberhard Breitmaier, and Gerhard Rücker. "Cucurbitacins from Wilbrandia ebracteata." Phytochemistry 31, no. 4 (1992): 1329–33. http://dx.doi.org/10.1016/0031-9422(92)80284-l.

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Sim, Hu-Sung, Byeong-Chur Jang, Hye-Min Park, Byeong-Yong Jeng, and Man-Jin Oh. "Isolation of Cucurbitacin E from Sprouted Pumpkin Seed and Analysis of Its Anti-cancer and Anti-inflammatory Activities." Journal of the Korean Society of Food Science and Nutrition 37, no. 7 (2008): 834–40. http://dx.doi.org/10.3746/jkfn.2008.37.7.834.

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Yu, Kun, Xinmei Yang, Ying Li, Xue Cui, Bo Liu, and Qingqiang Yao. "Synthesis of cucurbitacin IIa derivatives with apoptosis-inducing capabilities in human cancer cells." RSC Advances 10, no. 7 (2020): 3872–81. http://dx.doi.org/10.1039/c9ra09113k.

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Rodriguez, Nelson, Yelkaira Vasquez, Ahmed A. Hussein, Phyllis D. Coley, Pablo N. Solis, and Mahabir P. Gupta. "Cytotoxic Cucurbitacin Constituents fromSloaneazuliaensis." Journal of Natural Products 66, no. 11 (2003): 1515–16. http://dx.doi.org/10.1021/np0303106.

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Nayab, Durey, Dildar Ali, Nuzhat Arshad, Abdul Malik, M. Iqbal Choudhary, and Zaheer Ahmed. "Cucurbitacin glucosides fromCitrullus colocynthis." Natural Product Research 20, no. 5 (2006): 409–13. http://dx.doi.org/10.1080/14786410500044997.

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