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1

Breczko, Jacek. "Cud grecki." Σοφια 18 (2018): 19–36. http://dx.doi.org/10.15584/sofia.2018.18.2.

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2

Umapathi, Krishna Kishore, Aravind Thavamani, Harshitha Dhanpalreddy, and Hoang H. Nguyen. "Prevalence of cardiac arrhythmias in cannabis use disorder related hospitalizations in teenagers from 2003 to 2016 in the United States." EP Europace 23, no. 8 (2021): 1302–9. http://dx.doi.org/10.1093/europace/euab033.

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Abstract Aims Cannabis is an increasingly common recreational substance used by teenagers. However, there is limited data probing association of cardiac arrhythmias with marijuana use in this population. Methods and Results We provide prevalence trends, disease burden and healthcare utilization of cardiac arrhythmias associated with cannabis use disorder (CUD) in hospitalized teenagers (13–20 years) using a large national administrative database in the United States from 2003–2016. We used partial least square regression analysis for assessing trends in prevalence of cardiac arrhythmias and mu
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Foster, Katherine T., Brooke J. Arterberry, William G. Iacono, Matt McGue, and Brian M. Hicks. "Psychosocial functioning among regular cannabis users with and without cannabis use disorder." Psychological Medicine 48, no. 11 (2017): 1853–61. http://dx.doi.org/10.1017/s0033291717003361.

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AbstractBackgroundIn the United States, cannabis accessibility has continued to rise as the perception of its harmfulness has decreased. Only about 30% of regular cannabis users develop cannabis use disorder (CUD), but it is unclear if individuals who use cannabis regularly without ever developing CUD experience notable psychosocial impairment across the lifespan. Therefore, psychosocial functioning was compared across regular cannabis users with or without CUD and a non-user control group during adolescence (age 17; early risk) and young adulthood (ages 18–25; peak CUD prevalence).MethodWeekl
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Tavares, Marina R., Klára Hrabánková, Rafał Konefał, et al. "HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy." Pharmaceutics 13, no. 2 (2021): 179. http://dx.doi.org/10.3390/pharmaceutics13020179.

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The study describes the synthesis, physicochemical properties, and biological evaluation of polymer therapeutics based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers intended for a tumor-targeted immuno-oncotherapy. Water-soluble linear and cholesterol-containing HPMA precursors were synthesized using controlled reversible addition–fragmentation chain transfer polymerization to reach molecular weight Mn about 2 × 104 g·mol−1 and low dispersity. These linear or self-assembled micellar conjugates, containing immunomodulatory agent cucurbitacin-D (CuD) or the anticancer drug doxorubicin (
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Elsherif, Laila, Raymond V. Ortines, Jack T. Saari, and Y. James Kang. "Congestive Heart Failure in Copper-Deficient Mice." Experimental Biology and Medicine 228, no. 7 (2003): 811–17. http://dx.doi.org/10.1177/15353702-0322807-06.

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Copper Deficiency (CuD) leads to hypertrophic cardiomyopathy in various experimental models. The morphological, electrophysiological, and molecular aspects of this hypertrophy have been under investigation for a long time. However the transition from compensated hypertrophy to decompensated heart failure has not been investigated in the study of CuD. We set out to investigate the contractile and hemodynamic parameters of the CuD mouse heart and to determine whether heart failure follows hypertrophy in the CuD heart. Dams of FVB mice were fed CuD or copper-adequate (CuA) diet starting from the
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6

Chouairi, Fouad, Clancy W. Mullan, Neal Ravindra, et al. "Brief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018." PLOS ONE 16, no. 9 (2021): e0255514. http://dx.doi.org/10.1371/journal.pone.0255514.

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Background In the United States, both cannabis use disorder (CUD) and opioid use disorder (OUD) have increased in prevalence. The prevalence, demographics, and costs of CUD and OUD are not well known in heart failure (HF) admissions. This study aimed to use a national database to examine the prevalence, demographics, and costs associated with CUD and OUD in HF. Methods This study used the National Inpatient Sample from 2008 to 2018 to identify all primary HF admissions with and without the co-diagnosis of OUD or CUD using International Classification for Diagnosis, diagnosis codes. Demographic
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7

Aloi, Joseph, Marie C. McCusker, Brandon J. Lew, et al. "Altered amygdala-cortical connectivity in individuals with Cannabis use disorder." Journal of Psychopharmacology 35, no. 11 (2021): 1365–74. http://dx.doi.org/10.1177/02698811211054163.

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Background: Cannabis is one of the most commonly used substances in the United States. Prior literature using task-based functional magnetic resonance imaging (fMRI) has identified that individuals with Cannabis use disorder (CUD) show impairments in emotion processing circuitry. However, whether the functional networks involving these regions are also altered in CUD remains poorly understood. Aims: Investigate changes in resting-state functional connectivity (rsFC) in regions related to emotional processing in CUD. Methods: Sixty-two participants completed resting-state fMRI, including 21 wit
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Roser, Patrik, Eva-Maria Pichler, Benedikt Habermeyer, Wolfram Kawohl, and Georg Juckel. "Impact of Chronic Cannabis Use on Auditory Mismatch Negativity Generation in Schizophrenia Patients." Pharmacopsychiatry 52, no. 03 (2018): 126–33. http://dx.doi.org/10.1055/a-0573-9866.

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Abstract Introduction Cannabis use disorders (CUD) are highly prevalent among patients with schizophrenia (SCZ). Deficient mismatch negativity (MMN) generation is a characteristic finding in SCZ patients and cannabis users. This study therefore examined the effects of CUD on MMN generation in SCZ patients. Methods Twenty SCZ − CUD patients, 21 SCZ+CUD patients, and 20 healthy controls (HC) were included in this study. MMN to frequency and duration deviants was elicited within an auditory oddball paradigm and recorded by 32 channel EEG. Results As expected, SCZ − CUD patients showed reduced fro
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Fonseca, Francina, Joan-Ignasi Mestre-Pintó, Àlex Gómez-Gómez, et al. "The Tryptophan System in Cocaine-Induced Depression." Journal of Clinical Medicine 9, no. 12 (2020): 4103. http://dx.doi.org/10.3390/jcm9124103.

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Major depression disorder (MDD) is the most prevalent psychiatric comorbid condition in cocaine use disorder (CUD). The comorbid MDD might be primary-MDD (CUD-primary-MDD) or cocaine-induced MDD (CUD-induced-MDD), and their accurate diagnoses and treatment is a challenge for improving prognoses. This study aimed to assess the tryptophan/serotonin (Trp/5-HT) system with the acute tryptophan depletion test (ATD), and the kynurenine pathway in subjects with CUD-primary-MDD, CUD-induced-MDD, MDD and healthy controls. The ATD was performed with a randomized, double-blind, crossover, and placebo-con
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Kim, Myeong-Sun, Kangwook Lee, Jin Mo Ku, et al. "Cucurbitacin D Induces G2/M Phase Arrest and Apoptosis via the ROS/p38 Pathway in Capan-1 Pancreatic Cancer Cell Line." Evidence-Based Complementary and Alternative Medicine 2020 (September 22, 2020): 1–10. http://dx.doi.org/10.1155/2020/6571674.

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Pancreatic cancer has a poor prognosis with a five-year survival rate of less than 10%. Moreover, chemotherapy is mostly rendered ineffective owing to chemotherapy resistance and cytotoxicity. Therefore, the development of effective therapeutic strategies and novel drugs against pancreatic cancer is an urgent need. Cucurbitacin D (CuD), a plant steroid derived from Trichosanthes kirilowii, is an anticancer agent effective against various cancer cell lines. However, the anticancer activity and molecular mechanism of CuD in pancreatic cancer remain unknown. Therefore, we aimed to investigate the
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11

Lees, Rachel, Lindsey A. Hines, Deepak Cyril D'Souza, et al. "Psychosocial and pharmacological treatments for cannabis use disorder and mental health comorbidities: a narrative review." Psychological Medicine 51, no. 3 (2021): 353–64. http://dx.doi.org/10.1017/s0033291720005449.

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AbstractCannabis is the most widely used illicit drug worldwide, and it is estimated that up to 30% of people who use cannabis will develop a cannabis use disorder (CUD). Demand for treatment of CUD is increasing in almost every region of the world and cannabis use is highly comorbid with mental disorders, where sustained use can reduce treatment compliance and increase risk of relapse. In this narrative review, we outline evidence for psychosocial and pharmacological treatment strategies for CUD, both alone and when comorbid with psychosis, anxiety or depression. Psychosocial treatments such
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12

Pellegrino, Alexa J., Kerry D. Duck, Dylan P. J. Kriescher, et al. "Characterizing Symptoms of Cannabis Use Disorder in a Sample of College Students." Journal of Drug Issues 50, no. 4 (2020): 524–37. http://dx.doi.org/10.1177/0022042620936655.

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Since the legalization of marijuana in several U.S. states in 2012, there has been concern about increases in the development of cannabis use disorder (CUD). The current study examined rates of CUD in Colorado college students who reported regular marijuana use and assessed a range of factors associated with CUD symptoms, including coping motives, concentrate/dab use, mental health concerns (depression, anxiety), age of regular marijuana use, and alcohol use. College students were recruited from a mid-sized university and completed a baseline assessment that included a marijuana urine screen.
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13

Sproat, J. "Cud-dropping in sheep." Veterinary Record 123, no. 22 (1988): 582. http://dx.doi.org/10.1136/vr.123.22.582-a.

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14

Ye, Weijian, Bowen Yan, Jie Pang, et al. "A Study of the Synergistic Interaction of Konjac Glucomannan/Curdlan Blend Systems under Alkaline Conditions." Materials 12, no. 21 (2019): 3543. http://dx.doi.org/10.3390/ma12213543.

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To improve the gelation performance of konjac glucomannan (KGM) thermo-irreversible gel in the condition of alkaline, this study investigated the interactions between KGM and curdlan (CUD) in terms of the sol state and gelation process. The apparent viscosity, rheological properties during heating and cooling, thermodynamic properties, gelation properties and water holding capacity of KGM/CUD blend systems in an alkaline environment were studied using physical property testing instruments and methods. The results showed that the viscosity of the KGM/CUD blended solution was greater than the va
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15

Schimmelmann, B., S. Kupferschmid, P. Conus, S. Cotton, P. McGorry, and M. Lambert. "Cannabis use disorders and age at onset of psychosis in 606 patients with first episode psychosis." European Psychiatry 26, S2 (2011): 1500. http://dx.doi.org/10.1016/s0924-9338(11)73204-7.

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BackgroundAge at onset of psychosis (AAO) may be younger in patients with cannabis use disorders (CUD) compared to those without CUD (NCUD). Most previous studies did not control for potential confounders, did not report effect sizes and included mostly adult patients from non-representative samples.MethodsControlling for relevant confounders, differences in AAO between patients with and without lifetime CUD were analysed in a large epidemiologically based cohort of 606 first-episode psychosis (FEP) patients (age 14 to 29 years) admitted within three years to the Melbourne Early Psychosis Prev
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16

Nakanishi, Tsukasa, Yuan Song, Cuiying He, et al. "Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia." PeerJ 4 (May 12, 2016): e2026. http://dx.doi.org/10.7717/peerj.2026.

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We previously reported that the inflammasome inhibitor cucurbitacin D (CuD) induces apoptosis in human leukemia cell lines. Here, we investigated the effects of CuD and a B-cell lymphoma extra-large (Bcl-xL) inhibitor on autophagy in peripheral blood lymphocytes (PBL) isolated from adult T-cell leukemia (ATL) patients. CuD induced PBL cell death in patients but not in healthy donors. This effect was not significantly inhibited by treatment with rapamycin or 3-methyladenine (3-MA). The Bcl-xL inhibitor Z36 induced death in primary cells from ATL patients including that induced by CuD treatment,
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17

Sagar, Kelly, M. Kathryn Dahlgren, Rosemary Smith, Ashley Lambros, and Staci Gruber. "Assessing Cannabis Use Disorder in Medical Cannabis Patients: Interim Analyses from an Observational, Longitudinal Study." Cannabis 4, no. 2 (2021): 47–59. http://dx.doi.org/10.26828/cannabis/2021.02.004.

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Background: To date, no studies have directly assessed potential cannabis use disorder (CUD) in medical cannabis (MC) patients pre- vs post-MC treatment. Given that MC patients use cannabis for symptom alleviation rather than intoxication, we hypothesized that MC patients would exhibit few symptoms of CUD after initiating MC treatment. Methods: As part of an ongoing observational, longitudinal study, 54 MC patients completed baseline assessments prior to initiating MC use and returned for at least one follow-up assessment after three, six, and/or twelve months of a self-selected MC treatment r
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18

Sagar, Kelly, M. Kathryn Dahlgren, Rosemary Smith, Ashley Lambros, and Staci Gruber. "Assessing Cannabis Use Disorder in Medical Cannabis Patients: Interim Analyses from an Observational, Longitudinal Study." Cannabis 4, no. 2 (2021): 47–59. http://dx.doi.org/10.26828/cannabis/2021.02.004.

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Background: To date, no studies have directly assessed potential cannabis use disorder (CUD) in medical cannabis (MC) patients pre- vs post-MC treatment. Given that MC patients use cannabis for symptom alleviation rather than intoxication, we hypothesized that MC patients would exhibit few symptoms of CUD after initiating MC treatment. Methods: As part of an ongoing observational, longitudinal study, 54 MC patients completed baseline assessments prior to initiating MC use and returned for at least one follow-up assessment after three, six, and/or twelve months of a self-selected MC treatment r
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19

Mohanvel, Sucharitha Kannappan, Satish Kumar Rajasekharan, Trishna Kandhari, Balaji Prasanna Kumar Gopal Doss, and Yuvarani Thambidurai. "COW URINE DISTILLATE AS A BIOENHANCER FOR ANTIMICROBIAL & ANTIPROLIFERATIVE ACTIVITY AND REDISTILLED COW URINE DISTILLATE AS AN ANTICLASTOGEN AGENT." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (2017): 273. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.18879.

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Objective: The objective of this study was to prove that cow urine distillate (CUD) is a bioenhancer for antimicrobial activity and antiproliferative activity, redistilled CUD (RCUD) as an anticlastogen agent.Methods: The antimicrobial activity of rifampicin with CUD at different concentrations was determined against pathogenic Escherichia coli by well puncture method. The Penicillin and ciprofloxacin in combination with CUD at different/increasing concentrations against pathogenic E. coli culture were also determined by disc diffusion method. Sulforaphane (ACA) as an anticancer agent was extr
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20

Manni, Corrado, Giada Cipollone, Alessandro Pallucchini, Angelo G. I. Maremmani, Giulio Perugi, and Icro Maremmani. "Remarkable Reduction of Cocaine Use in Dual Disorder (Adult Attention Deficit Hyperactive Disorder/Cocaine Use Disorder) Patients Treated with Medications for ADHD." International Journal of Environmental Research and Public Health 16, no. 20 (2019): 3911. http://dx.doi.org/10.3390/ijerph16203911.

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Background: Cocaine use disorder (CUD) is a growing public health concern, but so far no effective pharmacotherapies have been demonstrated. Stimulant medications have proved to be promising in CUD treatment. The self-medication hypothesis (SMH) can help to explain this phenomenon better, especially in cases where CUD co-occurs with adult attention deficit hyperactivity disorder (A-ADHD). Methods: In the present retrospective study, a sample of 20 consecutive patients (aged from 18 to 65 years) with dual disorder (A-ADHD/CUD), under treatment with methylphenidate (MPH) or atomoxetine (ATM) med
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21

Farmer, R. F., D. B. Kosty, J. R. Seeley, et al. "Natural course of cannabis use disorders." Psychological Medicine 45, no. 1 (2014): 63–72. http://dx.doi.org/10.1017/s003329171400107x.

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BackgroundDespite its importance as a public health concern, relatively little is known about the natural course of cannabis use disorders (CUDs). The primary objective of this research was to provide descriptive data on the onset, recovery and recurrence functions of CUDs during the high-risk periods of adolescence, emerging adulthood and young adulthood based on data from a large prospective community sample.MethodProbands (n = 816) from the Oregon Adolescent Depression Project (OADP) participated in four diagnostic assessments (T1–T4) between the ages of 16 and 30 years, during which curren
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Alasmari, Fawaz, Sary Alsanea, Assim A. Alfadda, et al. "Serum Proteomic Analysis of Cannabis Use Disorder in Male Patients." Molecules 26, no. 17 (2021): 5311. http://dx.doi.org/10.3390/molecules26175311.

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Cannabis use has been growing recently and it is legally consumed in many countries. Cannabis has a variety of phytochemicals including cannabinoids, which might impair the peripheral systems responses affecting inflammatory and immunological pathways. However, the exact signaling pathways that induce these effects need further understanding. The objective of this study is to investigate the serum proteomic profiling in patients diagnosed with cannabis use disorder (CUD) as compared with healthy control subjects. The novelty of our study is to highlight the differentially changes proteins in t
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Woodhead, Erin L., Deborah Brief, Maureen Below, and Christine Timko. "Participation in 12-Step Programs and Drug Use Among Older Adults With Cannabis Use Disorder: Six-Month Outcomes." Journal of Drug Issues 51, no. 1 (2020): 38–49. http://dx.doi.org/10.1177/0022042620957013.

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This study examined associations among cannabis use disorder (CUD), 12-step program participation, and cannabis and other drug use at baseline and 3- and 6-month follow-ups. Participants were age 50 or older in a study of veterans receiving medical management of alcohol and/or opioid withdrawal ( N = 171). Generalized estimating equations examined the extent to which time point, 12-step program participation, and CUD were associated with change in number of cannabis and non-cannabis drug use days. Also examined was whether having CUD was associated with 12-step program participation. From base
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Kim, Soon Re, Hye Sook Seo, Han-Seok Choi, et al. "Trichosanthes kirilowiiEthanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/975350.

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Trichosanthes kirilowiituber is a traditional medicine which exhibits various medicinal effects including antidiabetic and anticancer activities in several cancer cells. Recently, it was reported that Cucurbitacin D (CuD) isolated fromTrichosanthes kirilowiialso induces apoptosis in several cancer cells. Constitutive signal transducer and activator of transcription 3 (STAT3), which is an oncogenic transcription factor, is often observed in many human malignant tumor, including breast cancer. In the present study, we tested whetherTrichosanthes kirilowiiethanol extract (TKE) or CuD suppresses c
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Olashore, Anthony A., Philip R. Opondo, John A. Ogunjumo, and James O. Ayugi. "Cannabis Use Disorder Among First-Year Undergraduate Students in Gaborone, Botswana." Substance Abuse: Research and Treatment 14 (January 2020): 117822182090413. http://dx.doi.org/10.1177/1178221820904136.

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Cannabis use disorder (CUD) poses major clinical and public health concerns globally. It is a growing problem among the youth in Botswana, yet little research has been done on this subject. The present study hoped to address this gap in knowledge by determining the prevalence and associated factors of CUD among first-year university students in Botswana. A cross-sectional study was conducted among 410 first-year university undergraduates, using a modified version of the 37-item World Health Organization (WHO) drug questionnaire and DSM-5 criteria for CUD. The mean age of the respondents was 20
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Xing, Hongtao, Siwei Zhang, H. Phillip Koeffler, and Ming Chiu Fung. "Cucurbitacin D Upregulates Fetal Hemoglobin Expression in K562 Cells and Human Erythroid Progenitors." Blood 110, no. 11 (2007): 3833. http://dx.doi.org/10.1182/blood.v110.11.3833.3833.

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Abstract The search for novel therapeutic candidates causing reactivation of fetal hemoglobin (a2g2; HbF) to reduce the imbalance of globin gene expression is important in order to develop effective approach for the clinical management of sickle cell anemia and b-thalassemia. For the first time, we have identified cucurbitacin D (CuD), a naturally occurring oxygenated tetracyclic triterpenoid, as a molecular entity inducing g-globin gene expression and HbF synthesis in K562 cells and human erythroid progenitors from either peripheral blood or bone marrow. The upregulation of HbF induced by CuD
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27

Schuschke, D. A., J. T. Saari, D. M. Ackermann, and F. N. Miller. "Microvascular responses in copper-deficient rats." American Journal of Physiology-Heart and Circulatory Physiology 257, no. 5 (1989): H1607—H1612. http://dx.doi.org/10.1152/ajpheart.1989.257.5.h1607.

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In this study on copper deficiency, the rat crewmaster microcirculation was used as a model for endogenous histamine release and platelet thrombi formation. Male Sprague-Dawley rats were fed either a copper-supplemented diet (CuS, 5 ppm) or a copper-deficient diet (CuD, 0 ppm) for 5 wk before experimentation. The crewmasters of anesthetized rats were spread in a Krebs-filed tissue bath. In venules of CuS animals, photoactivation of intravascular fluorescein isothiocyanate tagged to bovine serum albumin caused significant platelet aggregation and reduction of red blood cell column diameter (RBC
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Keshteli, Ammar Hassanzadeh, Awat Feizi, Ahmad Esmaillzadeh, et al. "Patterns of dietary behaviours identified by latent class analysis are associated with chronic uninvestigated dyspepsia." British Journal of Nutrition 113, no. 5 (2015): 803–12. http://dx.doi.org/10.1017/s0007114514004140.

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To our knowledge, no study has assessed the relationships between patterns of dietary behaviours, identified by latent class analysis (LCA), and chronic uninvestigated dyspepsia (CUD). The present study was conducted to determine the association between the patterns of dietary behaviours, identified by LCA, and CUD in a large sample of adults. In a cross-sectional study conducted on 4763 Iranian adults, we assessed the patterns of dietary behaviours in four domains, including ‘meal patterns’, ‘eating rate’, ‘intra-meal fluid intake’ and ‘meal-to-sleep interval’, as identified by LCA, using a p
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Reeves, Philip G., and Lana C. S. Demars. "Repletion of Copper-Deficient Rats with Dietary Copper Restores Duodenal Hephaestin Protein and Iron Absorption." Experimental Biology and Medicine 230, no. 5 (2005): 320–25. http://dx.doi.org/10.1177/153537020523000505.

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Copper (Cu) deficiency in rats reduces the relative concentration of duodenal hephaestin (Hp), reduces Iron (Fe) absorption, and causes anemia. An experiment was conducted to determine whether these effects could be reversed by dietary Cu repletion. Five groups of eight weanling male rats each were used. Group 1 was fed a Cu-adequate diet (5.0 mg Cu/kg; CuA) and Group 2 was fed a Cu-deflcient diet (0.25 mg Cu/kg; CuD) for 28 days. The rats were fed 1.0 g each of their respective diets labeled with 59Fe (37 kBq/g), and the amount of label retained was measured one week later by whole-body-count
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Hong, Ji-Sang. "Spin Polarization of CuD Nanowires." Journal of Magnetics 11, no. 1 (2006): 20–24. http://dx.doi.org/10.4283/jmag.2006.11.1.020.

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Sociedad, Delito y. "Estadísticas / Proyecto CINAP / Proyecto CUD." Delito y Sociedad 1, no. 1 (2003): 125–57. http://dx.doi.org/10.14409/dys.v1i1.93.

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Lominadze, David G., Jack T. Saari, Frederick N. Miller, James L. Catalfamo, David E. Justus, and Dale A. Schuschke. "Platelet Aggregation and Adhesion during Dietary Copper Deficiency in Rats." Thrombosis and Haemostasis 75, no. 04 (1996): 630–34. http://dx.doi.org/10.1055/s-0038-1650334.

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SummaryThe role of dietary copper deficiency in platelet-to-endothelial cell adhesion and in platelet-to-platelet aggregation was studied in vitro. Platelets were obtained from male, weanling Sprague-Dawley rats fed purified diets which were either copper-adequate (CuA, 6.3 μg copper/g of diet) or copper-deficient (CuD, 0.3 μg copper/g of diet) for 4 weeks. The platelet adhesion study was performed by adding CuA or CuD platelets either suspended in homologous plasma or in Tyrode buffer salt solution (TBSS) to cultured rat endothelial cells. After a one hour incubation at 37° C non-adhered plat
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Zhu, Youwei, Yan Zhao, Xiaomin Xu, et al. "Aberrant expression of BDNF might serve as a candidate target for cocaine-induced psychosis: insights from bioinformatics analysis and microarray validation." General Psychiatry 34, no. 5 (2021): e100587. http://dx.doi.org/10.1136/gpsych-2021-100587.

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BackgroundCocaine use disorder (CUD) and associated psychosis are major public health issues worldwide, along with high relapse outcome and limited treatment options. Exploring the molecular mechanisms underlying cocaine-induced psychosis (CIP) could supply integrated insights for understanding the pathogenic mechanism and potential novel therapeutic targets.AimsThe aim of the study was to explore common alterations of CUD-schizophrenia-target genes and identify core risk genes contributing to CIP through data mining and network pharmacology approach.MethodsTarget genes of CUD were obtained fr
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Mustapha, S. Ben, W. Homri, L. Jouini, and R. Labbane. "Bipolar disorder and co-occurring cannabis use disorders." European Psychiatry 41, S1 (2017): S466. http://dx.doi.org/10.1016/j.eurpsy.2017.01.522.

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AimsAssess the prevalence of cannabis use disorders (CUD) in patients with bipolar disorder, describe the demographic and clinical profile socio bipolar patients with comorbid addictive and assess the implications of this comorbidity on prognosis and evolution of bipolar disorder.MethodsA case-control study, 100 euthymic patients treated for bipolar disorder, recruited in the department of psychiatry C of Razi hospital. Two groups were individualized by the presence or not of cannabis use disorders comorbidity. The two groups were compared for sociodemographic, clinical, therapeutic and histor
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Millar, Seán R., Deirdre Mongan, Claire O’Dwyer, et al. "Correlates of patterns of cannabis use, abuse and dependence: evidence from two national surveys in Ireland." European Journal of Public Health 31, no. 2 (2021): 441–47. http://dx.doi.org/10.1093/eurpub/ckab007.

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Abstract Background Knowledge of factors relating to patterns of cannabis use is important for informing drug policy. This study determined factors associated with recent and current cannabis use. In addition, we explored factors related to having a cannabis use disorder (CUD)—defined using the Diagnostic and Statistical Manual of Psychiatric Disorders—among current users. Methods We analyzed data from Ireland’s 2010–11 and 2014–15 National Drug Prevalence Surveys, which recruited 5134 and 7005 individuals respectively, aged 15 years or more, living in private households. Multinomial logistic
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Bertram, Jonathan R., Amy Porath, Dallas Seitz, et al. "Canadian Guidelines on Cannabis Use Disorder Among Older Adults." Canadian Geriatrics Journal 23, no. 1 (2020): 135–42. http://dx.doi.org/10.5770/cgj.23.424.

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BackgroundCannabis Use Disorder (CUD) is an emerging and diverse challenge among older adults.MethodsThe Canadian Coalition for Seniors’ Mental Health, with financial support from Health Canada, has produced evidencebased guidelines on the prevention, identification, assessment, and treatment of this form of substance use disorder.ConclusionsOlder adults may develop CUD in the setting of recreational and even medical use. Clinicians should remain vigilant for the detection of CUD, and they should be aware of strategies for prevention and managing its emergence and consequences The full version
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Ouellet-Plamondon, C., A. Abdel-Baki, É. Salvat, and S. Potvin. "Specific impact of stimulant, alcohol and cannabis use disorders on first-episode psychosis: 2-year functional and symptomatic outcomes." Psychological Medicine 47, no. 14 (2017): 2461–71. http://dx.doi.org/10.1017/s0033291717000976.

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BackgroundMany studies have concluded that cannabis use disorder (CUD) negatively influences outcomes in first-episode psychosis (FEP). However, few have taken into account the impact of concurrent misuse of other substances.MethodsThis 2-year, prospective, longitudinal study of FEP patients, aged between 18 and 30 years, admitted to early intervention programs in Montreal, Quebec, Canada, examined the specific influence of different substance use disorders (SUD) (alcohol, cannabis, cocaine, amphetamines) on service utilization, symptomatic and functional outcomes in FEP.ResultsDrugs and alcoh
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Hjorthøj, Carsten, Md Jamal Uddin, Theresa Wimberley, et al. "M94. NO EVIDENCE OF ASSOCIATIONS BETWEEN GENETIC LIABILITY FOR SCHIZOPHRENIA RISK OF CANNABIS USE DISORDER." Schizophrenia Bulletin 46, Supplement_1 (2020): S170. http://dx.doi.org/10.1093/schbul/sbaa030.406.

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Abstract Background Cannabis use and cannabis use disorder (CUD) is increased in patients with schizophrenia. It is important to establish if this is explained by non-causal factors, such as shared genetic vulnerability. We aimed to investigate whether the polygenic risk scores (PRS) for schizophrenia and other psychiatric disorders would predict CUD in controls, patients with schizophrenia, and patients with other psychiatric disorders. Methods We linked nationwide Danish registers and genetic information obtained from dried neonatal bloodspots in an observational analysis. We included people
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Sabioni, Pamela, and Bernard Le Foll. "Psychosocial and pharmacological interventions for the treatment of cannabis use disorder." F1000Research 7 (February 12, 2018): 173. http://dx.doi.org/10.12688/f1000research.11191.1.

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Cannabis use has been continuously increasing, and cannabis use disorder (CUD) has become a public health issue. Some psychosocial interventions have demonstrated the ability to reduce cannabis use; however, there are no pharmacotherapies approved for the treatment of CUD. Some drugs have shown limited positive effects on use and withdrawal symptoms, but no controlled studies have been able to show strong and persistent effects on clinically meaningful outcomes. The aim of this review is to synthesize the evidence from the available literature regarding the effectiveness of psychosocial and ph
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Adamson, Sherleen Xue-Fu, Wei Zheng, Zeynep Sena Agim, et al. "Systemic Copper Disorders Influence the Olfactory Function in Adult Rats: Roles of Altered Adult Neurogenesis and Neurochemical Imbalance." Biomolecules 11, no. 9 (2021): 1315. http://dx.doi.org/10.3390/biom11091315.

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Disrupted systemic copper (Cu) homeostasis underlies neurodegenerative diseases with early symptoms including olfactory dysfunction. This study investigated the impact of Cu dyshomeostasis on olfactory function, adult neurogenesis, and neurochemical balance. Models of Cu deficiency (CuD) and Cu overload (CuO) were established by feeding adult rats with Cu-restricted diets plus ip. injection of a Cu chelator (ammonium tetrathiomolybdate) and excess Cu, respectively. CuD reduced Cu levels in the olfactory bulb (OB), subventricular zone (SVZ), rostral migratory stream (RMS), and striatum, while C
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Schulenberg, John E., Megan E. Patrick, Deborah D. Kloska, Julie Maslowsky, Jennifer L. Maggs, and Patrick M. O'malley. "Substance Use Disorder in Early Midlife: A National Prospective Study on Health and Well-Being Correlates and Long-Term Predictors." Substance Abuse: Research and Treatment 9s1 (January 2015): SART.S31437. http://dx.doi.org/10.4137/sart.s31437.

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This study used national multicohort panel data from the Monitoring the Future study ( N = 25,536 from senior year classes 1977–1997 followed up to the age of 35 years in 1994–2014) to examine how early midlife (age 35 years) alcohol use disorder (AUD) and cannabis use disorder (CUD) are associated with adolescent and adult sociodemographics and health and well-being risk factors. Survey items adapted from DSM-5 diagnostic criteria were used to identify individuals who (a) showed symptoms consistent with criteria for AUD or CUD at age 35 years, (b) used the substance without qualifying for a d
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Maij, David LR, Ben JM van de Wetering, and Ingmar HA Franken. "Cognitive control in young adults with cannabis use disorder: An event-related brain potential study." Journal of Psychopharmacology 31, no. 8 (2017): 1015–26. http://dx.doi.org/10.1177/0269881117719262.

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Contemporary models of substance use disorders emphasize the role of cognitive control, which has been linked to difficulties in resisting the use of substances. In the present study, we measured two aspects of cognitive control, response inhibition (operationalized by a Go/NoGo Task) and performance monitoring (operationalized by an Eriksen Flanker Task), in a group of young cannabis-use disorder (CUD) patients and compared these functions with two control groups (i.e. a group of cigarette smokers and a group of non-smokers). We employed both behavioural and electrophysiological measures. The
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Olesen, Julie Aamand, Christine Merrild Posselt, Chalotte Heinsvig Poulsen, Merete Nordentoft, and Carsten Hjorthøj. "Cannabis use disorders may protect against certain disorders of the digestive organs in people with schizophrenia but not in healthy controls." Psychological Medicine 50, no. 3 (2019): 499–506. http://dx.doi.org/10.1017/s0033291719000370.

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AbstractBackground. Previous studies have shown a potential for cannabis in disorders of the digestive organs. We aimed to investigate whether cannabis use disorders (CUD) would decrease the risk of incident disorders of the digestive organs, in people with schizophrenia and population controls.Methods. We combined nationwide Danish registers to identify 21 066 cases with schizophrenia and 176 935 sex-and-age-matched controls. Two models were analyzed for the associations between CUD and digestive disorders in time-varying Cox regressions: one adjusted for sex, year of birth, and calendar year
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Umang Haribhai Gajjar, Niralee Kalpeshkumar Velhal, Hetvi Girdharbhai Parikh, Jayrajsinh Bhartbhai Parmar, Yash Bhut, and Viral Rupeshbhai Patel. "Evaluation of antioxidant activity of unpurified and purified datura seed." World Journal of Biology Pharmacy and Health Sciences 7, no. 1 (2021): 030–35. http://dx.doi.org/10.30574/wjbphs.2021.7.1.0070.

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Aim: Evaluation of effect of shodhana process of datura seed (Datura stramonium) antioxidant activity. Methods: The datura was purified with two different processes viz. cow’s urine, and cow’s milk by Dolayantra method. Antioxidant activity was evaluated by in-vitro 1,1-Diphenyl-2-picryl hydrazyl (DPPH) radicals scavenging activity and Ferric reducing power ability (FRPA) assay. Result: cow urine purified datura (CUD) showed a significant effect in inhibiting DPPH, reaching up to 85.96% at concentration 1000 mcg/ml and its IC50 was 314.3 mcg/ml while Unpurified Datura Seed (UD) reaching up to
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Moura, José Helder Andrade de, Gherman Garcia Leal de Araújo, Edilson Paes Saraiva, et al. "Ingestive behavior of crossbred Santa Inês sheep fed water with different salinity levels." Semina: Ciências Agrárias 37, no. 2 (2016): 1057. http://dx.doi.org/10.5433/1679-0359.2016v37n2p1057.

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The objective of the present study was to evaluate the effect of four water salinity levels on the ingestive behavior of non-castrated crossbred Santa Inês sheep. Thirty-two non-castrated crossbred Santa Inês sheep in feedlot, at seven months of age and initial average weight of 21.76±1.25 kg, were used in the experiment. The experimental design was completely randomized, with four treatments and eight replicates. Four concentrations of salts in the water fed to the animals were evaluated: low (640 mg/l); medium (3,188 mg/l); high (5,740 mg/l) and very high (8,326 mg/l) levels of total dissolv
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46

Hutchinson, Allan C. "Chewing Cud: Revisiting Hart and Jurisprudence." Jurisprudence 5, no. 1 (2014): 29–40. http://dx.doi.org/10.5235/20403313.5.1.29.

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47

Dal Palù, Alessandro, Agostino Dovier, Andrea Formisano, and Enrico Pontelli. "CUD@SAT: SAT solving on GPUs." Journal of Experimental & Theoretical Artificial Intelligence 27, no. 3 (2014): 293–316. http://dx.doi.org/10.1080/0952813x.2014.954274.

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Derakhshan, I. "Crossed-uncrossed difference (CUD) in a new light: anatomy of the negative CUD in Poffenberger's paradigm." Acta Neurologica Scandinavica 113, no. 3 (2006): 203–8. http://dx.doi.org/10.1111/j.1600-0404.2005.00563.x.

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POBOŻNIAK, M., and E. H. KOSCHIER. "Effects of pea (Pisum sativum L.) cultivars on Thrips tabaci Lindeman preference and performance." Journal of Agricultural Science 152, no. 6 (2013): 885–93. http://dx.doi.org/10.1017/s0021859613000518.

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SUMMARYThe polyphagous onion thrips Thrips tabaci Lindeman (Thysanoptera: Thripidae) is a serious pest in many protected and field crops and has recently been found to occur in high numbers in Pisum sativum L. crops. In the present study, the abundance of T. tabaci was compared on two pea cultivars in the field. Data on sweep net catches at different sampling times during the day suggest that peak activity of the thrips is at noon. Significantly more thrips larvae and adults were caught on the early pea cultivar Cud Kelwedonu compared with the very early cultivar Pionier, particularly during a
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Laprevote, V., A. L. Devin, B. Blanc, and R. Schwan. "Influence of Impulsivity During Decision-making in Regular Cannabis Users." European Psychiatry 41, S1 (2017): S205. http://dx.doi.org/10.1016/j.eurpsy.2017.01.2162.

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IntroductionRegular cannabis use is associated with cognitive impairments, including impaired decision making measured by the Iowa Gambling Task. The question remains whether the impulsivity measured in regular cannabis users may participate to impaired decision making. Interestingly, the Cambridge Gambling Task (CGT) is a computerized gambling task allows to differentiate risk taking and impulsivity when making a decision.AimsThis study aims at separately exploring the impact of regular cannabis use on risk taking and impulsivity during decision making process.ObjectivesTo do so, we compared
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