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Dissertations / Theses on the topic 'Cultura neuronal'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Vieira, Hermany Munguba. "Indicadores de c?lcio e de voltagem codificados geneticamente na detec??o de potenciais de a??o e inputs sin?pticos em cultura de neur?nios hipocampais." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17026.

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Made available in DSpace on 2014-12-17T15:28:52Z (GMT). No. of bitstreams: 1 HermanyMV_DISSERT.pdf: 1765987 bytes, checksum: dedd84315ca1c69652d27407ffd67d85 (MD5) Previous issue date: 2013-03-04<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Recently, genetically encoded optical indicators have emerged as noninvasive tools of high spatial and temporal resolution utilized to monitor the activity of individual neurons and specific neuronal populations. The increasing number of new optogenetic indicators, together with the absence of comparisons under identical conditions, h

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2

Teller, Amado Sara. "Functional organization and networ resilience in self-organizing clustered neuronal cultures." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/396114.

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Major dynamical traits of a neuronal network are shaped by its underlying circuitry. In several neurological disorders, the deterioration of brain's functionality and cognition has been ascribed to changes in the topological properties of the brain's circuits. To deepen in the understanding of the activity-connectivity relationship, neuronal cultures have emerged as remarkable systems given their accessibility and easy manipulation. A particularly appealing configuration of these in vitro systems consists in an assembly of interconnected aggregates of neurons termed 'clustered neuronal network

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3

Fardet, Tanguy. "Growth and activity of neuronal cultures : emergence of organized behaviors." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC002/document.

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Dans cette thèse, je propose plusieurs modèles et outils numériques afin de mieux comprendre et prédire le comportement et le développement de cultures et dispositifs neuronaux.Les cultures de neurones ont en effet été un outil précieux durant les 20 dernières années : elles ont permis de mieux comprendre la manière dont le cerveau traite les différentes informations qui lui parviennent en donnant aux scientifiques la possibilité de tester les effets de médicaments sur les neurones, ainsi que d'obtenir leurs réponses détaillées à diverses perturbations et stimuli.De plus, de récentes avancées

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4

Gaffuri, Anne-Lise. "Drosophila melanogaster, as a model system to study the cell biology of neuronal GPCRs." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T063.

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Le récepteur cannabinoique de type 1 (CB1R) est l’un des récepteurs couplés aux protéines G les plus abondants du cerveau mammifère. CB1R a longtemps été décrit comme un récepteur présynaptique régulant de manière rétrograde la transmission synaptique. Cependant, depuis les vingt dernières années, de nouveaux rôles ont été découverts et il est maintenant clairement admis que l’action des endocannabinoides (eCBs) ne se limite pas à la régulationde la neurotransmission au niveau de synapses adultes déjà établies. En effet, les eCBs et le CB1R sont des acteurs majeurs de l’ensemble des phases du

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5

Chaves, Gabriela Pena. "Sistema canabinóide e seu possível papel em processos de neuroproteção e plasticidade: estudos in vivo e in vitro." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-03102008-113207/.

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O sistema canabinóide parece participar de vários processos neurobiológicos, incluindo neuroproteção e plasticidade. Os objetivos deste estudo foram avaliar os efeitos de ablações retinianas sobre a expressão do receptor canabinóide CB1 e de proteínas estruturais no tecto óptico de pintos pelos métodos de imuno-histoquímica, immunoblotting e PCR em tempo real. Além disso, avaliamos os efeitos do tratamento com agonistas e antagonistas canabinóides em culturas de células do tecto óptico expostas ao NMDA por citometria de fluxo e quanto à morfologia. A ablação retiniana parece gerar um aumento d

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Downes, Julia H. "Evolution of a complex neuronal network : characterising and influencing the functional connectivity of cultured neurones." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.552990.

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Cultures of living cortical neurones, grown in vitro, provide a model of brain function, their longevity plus their openness to experimental manipulation and detailed observation, makes them ideally suited to investigations of micro-scale neural interactions. Functional connectivity between neural units can be defined according to the correlation of their activity, and the functional networks of mature cultured neurones have revealed a complex network organisation. Sharing many properties with other complex networks, such as the Internet, social networks and in vivo brain networks, cultures al

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7

Johnstone, Alex. "Microfluidic systems for neuronal cell culture." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/37822/.

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At a high level of abstraction, the brain is a system for analysing sensory information, and responding appropriately. That information is encoded and stored in the millions of neural circuits that comprise the brain. Deciphering this code is essential to understanding how memories are implemented in physiologically normal brain tissue, and to inferring the nature of some neurological disorders affecting memory such as Alzheimer’s disease, in which the neural encoding is aberrant or unsuccessful. One approach to this problem is to reduce the complexity of the brain functionality to three eleme

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8

Gómez, Orlandi Javier. "Noise, coherent activity and network structure in neuronal cultures." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/346925.

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In this thesis we apply a multidisciplinary approach, based on statistical physics and complex systems, to the study of neuronal dynamics. We focus on understanding, using theoretical and computational tools, how collective neuronal activity emerges in a controlled system, a neuronal culture. We show how the interplay between noise and network structure defines the emergent collective behavior of the system. We build, using theory and simulation, a framework that takes carefully describes spontaneous activity in neuronal cultures by taking into account the underlying network structure of n

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9

Hernández, Navarro Lluís. "Theoretical and experimental approaches for the initiation and propagation of activity in spatially embedded neuronal cultures." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/565905.

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Spatial embedding and inherited metric constraints are a fundamental trait of biological neuronal circuits. However their role in shaping connectivity and dynamics has been often disregarded, with models of neuronal networks paying much more attention to the distribution of connections in the quest for understanding network's behavior. In this thesis we aim at filling this gap by studying the importance of metric features in the complex connectivity- dynamics-noise interplay that shapes spontaneous neuronal activity. This thesis combines experiments in rat dissociated neuronal cultures with

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10

Tibau, Martorell Elisenda. "Linear and nonlinear approaches to unravel dynamics and connectivity in neuronal cultures." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/460683.

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In the present thesis, we propose to explore neuronal circuits at the mesoscale, an approach in which one monitors small populations of few thousand neurons and concentrates in the emergence of collective behavior. In our case, we carried out such an exploration both experimentally and numerically, and by adopting an analysis perspective centered on time series analysis and dynamical systems. Experimentally, we used neuronal cultures and prepared more than 200 of them, which were monitored using fluorescence calcium imaging. By adjusting the experimental conditions, we could set two basic arr

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11

Jiang, Xiaosong. "Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture : transcription regulation mediated by cAMP-dependent signaling /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20JIANG.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 132-149). Also available in electronic version. Access restricted to campus users.

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Šmít, Daniel. "Analysis of dynamical interactions of axon shafts and their biophysical modelling." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066095/document.

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La fasciculation des axones joue un rôle essentiel dans le développement des réseaux neuronaux. Cependant, la dynamique de la fasciculation axonale, ainsi que les mécanismes biophysiques à l’œuvre dans ce processus, demeurent encore très mal compris. En vue d'étudier les mécanismes de fasciculation d'axones ex vivo, nous avons développé un système modèle simple, constitué par des explants d'épithélium olfactif de souris embryonnaires en culture, à partir desquels poussent les axones des neurones sensoriels olfactifs. Grâce à une étude en vidéomicroscopie, nous avons observé que ces axones inte

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13

Croce, Ariane. "Etude des régulations de l'activité neuronale par la noradrénaline dans les neurones hippocampiques de rat en culture primaire." Montpellier 2, 2003. http://www.theses.fr/2003MON20062.

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14

Cerruti, Catherine. "Etude, sur des neurones en culture primaire, du transporteur de la dopamine, au moyen d'un inhibiteur spécifique, la BTCP : pharmacologie, influence sur la maturation neuronale, neuroprotection." Montpellier 2, 1991. http://www.theses.fr/1991MON20167.

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Les etudes pharmacologiques, sur membranes striatales et sur neurones en cultures primaires, ont montre que la btcp, derive de la phencyclidine (pcp), se lie avec une haute affinite sur le complexe de recapture de la dopamine, dont elle inhibe selectivement le transport. L'utilisation de la btcp, comme outil de marquage des sites de recapture de la dopamine, a permis de localiser ces derniers dans les zones de l'encephale de rat adulte riches en elements dopaminergiques (striatum et substance noire) et sur l'ensemble du neurone exprimant la dopamine en culture (au niveau des membranes terminal

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15

Guo, Aobo. "Progranulin (PGRN) functions in neuronal cultures." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/12702.

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Null mutations in the progranulin gene (PGRN) have been identified as a major cause of frontotemporal lobe dementia with ubiquitinated inclusions (FTLD-U). In this disorder, the ubiquitinated aggregated protein inclusions of a normally nuclear-located RNA processing protein called TAR DNA binding protein (TDP-43) accumulate in the cytoplasm of neurons. To determine whether aspects of this clinical pathology can be established in primary cultures of mouse cortical neurons, PGRN levels were knocked down in cultures using lentiviral vectors to introduce siRNA constructs. Similar to observations i

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16

Lavergne, Pauline, and Pauline Lavergne. "Caractérisation des réponses de neurones corticaux de rat en culture suite à des stimulations glutamatergiques grâce à la microscopie holographique numérique : vers une mesure de la balance excitation/inhibition." Master's thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/38153.

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De nouvelles preuves suggèrent que les dysfonctionnements des circuits sous-jacents aux symptômes et aux déficits cognitifs des maladies psychiatriques pourraient être causés par une altération des paramètres d'équilibre d’excitation/inhibition (E/I). Cependant, les preuves physiologiques directes de cette hypothèse à partir de données électrophysiologiques et de neuro-imagerie non invasives sont jusqu'à présent rares. Pour apporter un soutien supplémentaire à l’hypothèse de l’équilibre E/I, la présente étude a appliqué une approche avancée de microscopie holographique numérique (MHN) pour exa

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O'Leary, Tracy Ann. "Allylamine plasma polymers as novel neuronal culture substrates." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251493.

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18

Wyart, Claire. "Dynamique de l'activité spontanée dans des réseaux de neurones hippocampiques d'architecture contrôlée en culture." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. https://publication-theses.unistra.fr/public/theses_doctorat/2003/WYART_Claire_2003.pdf.

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De l'activité électrique spontanée est observée dans de nombreuses structures cérébrales. C'est pour explorer les mécanismes d'initiation et de persistance et le rôle de l'architecture fonctionnelle dans l'activité spontanée que nous avons mis au point une approche de culture où l'architecture des réseaux de neurones hippocampiques est contrôlée par traitement des surfaces d'adhésion. L'activité spontanée a été mesurée par la technique de patch clamp sur 1 ou 2 neurones avec une résolution de 0. 1ms, et en imagerie de fluorescence avec la sonde Fura-2 liant le calcium dans tous les neurones d'

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19

Spinoglio, Francesco. "Las pirámides etnolingüísticas. Estudio contrastivo entre el español y el italiano basado en corpus." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/459071.

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En esta tesis de investigación, de carácter interlingüístico por ahondar en los contrastes entre lenguas e interdisciplinar por acercarse a la neurociencia, se realiza un estudio contrastivo desde la perspectiva de la etnolingüística entre el español y el italiano, y se propone una visualización de datos que hemos denominado "pirámides etnolingüísticas". Para llevar a cabo el estudio, se han escogido tres ámbitos culturales concretos (la religión, el fútbol y los toros) y se han formulado tres hipótesis de partida: en primer lugar, que es en las expresiones donde se puede apreciar la influenc

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20

Boulos, Sherif. "Identification and characterisation of potential neuroprotective proteins induced by erythropoietin (EPO) preconditioning of cortical neuronal cultures." University of Western Australia. School of Biomedical and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0128.

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[Truncated abstract] Clinical therapeutic agents to directly inhibit ischaemic neuronal death are presently unavailable. One approach to developing therapeutics is based upon the identification of proteins up-regulated by 'preconditioning', a natural adaptive response utilised by the neural cells to counter damaging insults, such as ischaemia. Thus, my project aimed to firstly identify proteins differentially expressed following erythropoietin (EPO) mediated neuronal preconditioning and secondly to assess whether any of these proteins possessed neuroprotective activity using in vitro ischaemia

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21

Robert, Fabienne. "Aspects ultrastructuraux et neurochimiques des astrocytes et des neurones en culture : influence des antibiotiques." Orléans, 2003. http://www.theses.fr/2003ORLE2034.

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Les cultures d'astrocytes et de neurones sont des modèles couramment utilisés pour l'étude des fonctions du système nerveux central. Le but du présent travail est la recherche de l'influence des conditions de culture sur les astrocytes et les neurones. L'étude ultrastructurale montre la présence de mitochondries difformes et de vésicules multilamellaires dans les cellules. Les antibiotiques utilisés en culture renforcent la présence des vésicules multilamellaires. L'utilisation de traceurs du système endolysosomal montre que ces vésicules sont d'origine lysosomale. Les antibiotiques modifient

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22

Xydas, Dimitris. "Investigation of spatiotemporal state dynamics in neuronal cultures." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558807.

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Biological neuronal cultures offer the unique opportunity to study the emergent behaviour of networks comprised of a large number of neurones within a controlled environment. Such neurones typically develop random interconnections, yet exhibit certain spontaneous properties reflective of their original function. In vitro cultures are maintained and ob- served using specialised multi-electrode arrays (MEAs), which record their activity in the form of extracellular voltages called spikes and are able to concurrently stimulate them at multiple locations via electrical impulses. Currently, culture

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De, La Garza Richard. "Determination of neuronal morphology in spinal monolayer cultures." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc798395/.

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The objective of the completed research was to characterize the morphology of individual neurons within monolayer networks of fetal mouse spinal tissue via intraperikaryal injections of horseradish peroxidase (HRP). Thirty labelled neurons were reconstructed via camera lucida drawings and morphometrically analyzed.

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24

Martin-Biran, Magali. "Etude par spectroscopie de RMN du métabolisme des neurones et des astrocytes en culture primaire." Bordeaux 2, 1994. http://www.theses.fr/1994BOR28314.

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Dans la perspective de mieux comprendre les phénomènes de compartimentation cellulaire au sein du système nerveux central, nous avons choisi de définir les caractéristiques métaboliques des neurones et des astrocytes en culture primaire homogène. Le devenir métabolique du [1-13C]glucose dans les neurones et les astrocytes cérébelleux, de même que dans les astrocytes corticaux, a été caractérisé par spectroscopie de RMN. Les astrocytes, contrairement aux neurones, synthétisent la glutamine. La maturation des voies de biosynthèse de cet acide aminé est retardée dans les astrocytes cérébelleux pa

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Auboyer, Laura. "Génération de cellules souches pluripotentes induites de patients Alzheimer et production d'un modèle de culture en trois dimensions de neurones pour les recherches diagnostiques et thérapeutiques de la maladie d’Alzheimer." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT004/document.

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La maladie d’Alzheimer est une maladie très complexe, aujourd’hui encore mal comprise et cette démence est devenue un réel problème de santé publique. La protéine précurseur de l’amyloïde (APP) et la protéine Tau sont deux acteurs majeurs impliqués dans la maladie. De nombreuses recherches se sont investies dans la compréhension du métabolisme, de l’action et de l’implication de ces deux protéines dans les mécanismes pathologiques de la maladie et d’autres maladies neurodégénératives. Elles sont notamment l’objet de la plupart des approches thérapeutiques passées et actuelles, et étudiées pour

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Luhr, Katarina. "Prion processing and propagation in neuronal and dendritic cell culture models /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-991-9.

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27

Sünwoldt, Juliane [Verfasser]. "Neuronal culture microenvironments determine preferences in bioenergetic pathway use / Juliane Sünwoldt." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1170814611/34.

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Rogers, A. T. "Spinal cord cell culture : a model for neuronal development and disease." Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234048.

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29

Choi, Yoonsu. "A Three-Dimensional Coupled Microelectrode and Microfluidic Array for Neuronal Interfacing." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/11638.

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The objective of this research is to develop a three-dimensional (3-D) microfluidic/ electronic interface system for sustaining and monitoring 3-D neuronal networks. This research work is divided into two parts. One is the development of a 3-D multi-electrode array (MEA) with integrated microfluidic channels. The other is a microneedle array with embedded microelectrodes and microfluidic channels. The 3-D MEA is composed of three elements that are essential for the development and monitoring of 3-D cultures of neurons. These components consist of scaffolds for cellular growth and structural

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30

Bigot, Dominique. "Réorganisation du cytosquelette neuronal après stimulation des cultures de neurones du cortex ou de la moelle épinière de rat par les acides aminés excitateurs." Paris 5, 1991. http://www.theses.fr/1991PA05P607.

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Carter, Janet. "Mechanisms of neurofilament accumulation : relevance to Lewy body formation." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263811.

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Larsen, Hege Ekeberg. "Neuronal control of cardiac excitability in pro-hypertensive states." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:04d38eb6-ea66-4283-91ab-dd75bca246e9.

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Hypertension is associated with marked cardiac sympathetic over-activity and end organ hyper-responsiveness. The sympathetic dysfunction is caused by aberrant calcium (Ca<sup>2+</sup>) handling resulting in enhanced neurotransmission. However, it remains unclear whether the sympathetic neuron or the myocytes is the primary driver behind the initiation and maintenance of the autonomic phenotype. The work in this thesis characterises the Ca<sup>2+</sup> dysfunction and regulation at the membrane level. Further, it employs physiologically coupled sympathetic neurons and ventricular myocytes to de

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33

Piccinotti, Silvia. "Rabies Glycoprotein-Mediated Uptake Into Epithelial Cells and Compartmentalized Primary Neuronal Culture." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845493.

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Rabies virus (RABV) subverts host neuronal circuitry to gain access to the brain where it causes generally incurable, lethal encephalitis. The single glycoprotein (G) dictates two defining steps for infection and neuroinvasion: receptor-mediated endocytosis and transport of virus. We generate two recombinant VSV (rVSV) clones that genetically incorporate G (rVSV RABV G) from the fixed RABV strains, SAD B19 and CVS, to study internalization into epithelial cells and compartmentalized primary cultures of peripheral neurons. Through the use of chemical inhibitors and markers for specific endocyti

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Lui, Pik Wa. "Modulation of N-methyl-D-aspartate receptor expression in neuronal cell culture." HKBU Institutional Repository, 2002. http://repository.hkbu.edu.hk/etd_ra/419.

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Cēbers, Gvido. "Modulation of AMPA glutamate receptor functions in primary neuronal cultures /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3424-X/.

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Srinath, Chetan. "mRNA stability in soma and neurites of cultured neuronal cells." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111314.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 45-50).<br>Neurons rely on mRNA localization and local protein synthesis in neurites to regulate synaptic plasticity, axonogenesis and neural signaling. The local regulation of mRNA stability in neurites is poorly understood. To determine mRNA decay rates, we analyzed the subcellular transcriptomes of neural projections and soma of mouse neuronal cells following inhibition of transcription with actinomycin-D. Less stable transc

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Morefield, Samantha I. (Samantha Irene). "Responses of Cultured Neuronal Networks to the Cannabinoid Mimetic Anandamide." Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc277717/.

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The effects of cannabinoid agonists on spontaneous neuronal network activity were characterized in murine spinal cord and auditory cortical cultures with multichannel extracellular recording using photoetched electrode arrays. Different cultures responded reproducibly with global decreases of spiking and bursting to anandamide and methanandamide, but each agonist showed unique minor effects on network activity. The two tissues responded in a tissue-specific manner. Spontaneous activity in spinal tissue was terminated by 1 μM anandamide and 6.1 μM methanandamide. Cortical activity ceased at 3.5

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Li, Ka Wai. "Neuroprotective roles of cefriaxone on cultured astrocytes and neuronal cells." HKBU Institutional Repository, 2011. http://repository.hkbu.edu.hk/etd_ra/1277.

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Golas, Lillian B. "Mechanosensory neurons in culture : morphology and electrophysiology." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56638.

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Crustacean mechanosensory neurons, isolated by enzymatic digestion from abdominal muscle receptor organs of Homarus americanus and Procambarus clarkii, maintain characteristic morphological and electrophysiological phenotypes in culture. New outgrowth occurs at both the axonal and dendritic poles. The patterns of outgrowth are distinct and in keeping with the sensory function. The cut axonal end gives rise to few elongated processes which rarely branch. In contrast, the new growth at the dendritic pole consists of multiple, short ($<$10 um) processes which resemble normal sensory termini. Cult

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Chateau, Yannick. "Co-culture compartimentée de cellules épidermiques et cellules nerveuses : modèle d'étude des interactions neuro-cutanées." Brest, 2005. http://www.theses.fr/2005BRES3108.

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Le traitement de l’information sensorielle suite à un stimulus externe a comme point de départ l’activité d’une population variée de récepteurs cutanés et sous-cutanés. Les corps cellulaires de ces récepteurs se situent dans les ganglions des racines dorsales (GRD). Ils sont reliés à la moelle épinière (ME) par des neurites. Le challenge pour réaliser un modèle d’étude in vitro des interactions neuro-cutanées réside dans la reproduction de la suite physiologique (peau, neurones des GRD, neurones sensitifs de la ME) et dans la formation de connexions entre cellules épidermiques et neurites des

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Afanasenkau, Dzmitry [Verfasser]. "Supported lipid bilayer as a biomimetic platform for neuronal cell culture / Dzmitry Afanasenkau." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1035689995/34.

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Sertel, Sinem Meleknur [Verfasser]. "Time- and gender- dependent differences in neuronal behaviors in culture / Sinem Meleknur Sertel." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1233481290/34.

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Peritore, Carina S. "Biological applications of boronate optical probes, neurotoxins and antioxidants in neuronal cell culture." Thesis, Boston University, 2012. https://hdl.handle.net/2144/31594.

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Thesis (Ph.D.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>The neurochemistry of hydrogen peroxide (H2 O2) in living systems has received increased attention owing to its contributions as a marker for oxidative stress and damage events associated with neurodegenerati

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Zala, Diana. "Huntington's disease modeling and treatment : from primary neuronal cultures to rodents /." [S.l.] : [s.n.], 2005. http://library.epfl.ch/theses/?nr=3137.

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Harbeby, Emilie. "Impact de l'apport alimentaire en AGPI n-3 sur le métabolisme énergétique cérébral : approches in vivo chez le rat en situation de repos ou d'activation neuronale et in vitro sur un modèle d'astrocytes en culture primaire." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00653444.

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Le métabolisme énergétique cérébral via l'utilisation du glucose est fortement impliqué dans la production d'énergie nécessaire au fonctionnement du neurone en situation basale et d'activation. Des travaux précédents ont mis en évidence chez le rat chroniquement déficient en acides gras polyinsaturés (AGPI) de la série n-3 une altération de ce métabolisme en situation basale (diminution de l'utilisation cérébrale du glucose et de la densité des transporteurs de glucose GLUT1). Pour cerner les différentes étapes du métabolisme énergétique pouvant être modifiées par les AGPI n-3, l'expression de

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McGrath, Andrew J. "Beyond Plasticity: Cochlear Implants, Family Objects, and Quasi-Neuronal Lives." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504781636219078.

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Wu, Calvin. "In Vitro Cortical Networks for Disease Modeling and Drug Evaluation." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc407860/.

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In translational research, disease models in preclinical studies are used as media for discovery of drugs or novel therapeutics. Development of in vitro models for various neurological diseases that enable efficient pharmacological or toxicological screening has been ongoing but challenging. Recognizing the potential benefit of in vitro disease models, dysfunctions in the cortical neuronal networks were induced to mimic the functional pathology of neurological symptoms using microelectrode arrays. Two different disease states – tinnitusand excitotoxicity – were investigated and discussed. In t

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Oillet, Jean. "Caractérisation d'un modèle d'étude de l'hypoxie sur les neurones centraux en culture : évaluation du rôle des radicaux libres et des acides aminés excitateurs." Nancy 1, 1996. http://www.theses.fr/1996NAN12152.

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Plachez, Céline. "Etude des transporteurs du glutamate au cours du développement "in vitro" des neurones hippocampiques." Montpellier 2, 2001. http://www.theses.fr/2001MON20002.

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Le glutamate, principal neurotransmetteur excitateur du snc de mammifere adulte, a un role neurotrophique au cours du developpement. La regulation de son taux extracellulaire par des transporteurs s'avere importante. Cinq transporteurs existent : glast et glt localises sur les astrocytes et eaac, eaat4 et eaat5 situes sur les neurones. L'expression et la fonctionnalite de glast, glt et eaac ont ete etudiees au cours du developpement in vitro de neurones hippocampiques de rat. Eaac, est exprime par les neurones, mais glast et glt, presents sur les cellules gliales, sont aussi exprimes transitoi

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Rouvas, Alkisti. "The development of mammalian cholinergic neurons in culture." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110752.

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Cholinergic signaling is important in the physiological functions of several organs, including the heart, lungs and bladder, and in centrally mediated physiological functions such as learning, memory, movement, circadian rhythm, and sleep-wake cycles. During high frequency firing, most of the acetylcholine (ACh) is released and the cholinergic nerve terminal must continuously resynthesize ACh using choline acetyltransferase (ChAT) in order to contend with its demand. The rate-limiting step for the ACh synthesis reaction is the uptake of choline into the presynaptic terminal through the high af

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