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Journal articles on the topic 'Cumulative Oxidative Stress'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Manti, Sara, Lucia Marseglia, Gabriella D’Angelo, et al. "“Cumulative Stress”: The Effects of Maternal and Neonatal Oxidative Stress and Oxidative Stress-Inducible Genes on Programming of Atopy." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/8651820.

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Although extensive epidemiological and laboratory studies have been performed to identify the environmental and immunological causes of atopy, genetic predisposition seems to be the biggest risk factor for allergic diseases. The onset of atopic diseases may be the result of heritable changes of gene expression, without any alteration in DNA sequences occurring in response to early environmental stimuli. Findings suggest that the establishment of a peculiar epigenetic pattern may also be generated by oxidative stress (OS) and perpetuated by the activation of OS-related genes. Analyzing the role

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Fanlo-Ucar, Hugo, Pol Picón-Pagès, Víctor Herrera-Fernández, Gerard ILL-Raga, and Francisco J. Muñoz. "The Dual Role of Amyloid Beta-Peptide in Oxidative Stress and Inflammation: Unveiling Their Connections in Alzheimer’s Disease Etiopathology." Antioxidants 13, no. 10 (2024): 1208. http://dx.doi.org/10.3390/antiox13101208.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease, and it is currently the seventh leading cause of death worldwide. It is characterized by the extracellular aggregation of the amyloid β-peptide (Aβ) into oligomers and fibrils that cause synaptotoxicity and neuronal death. Aβ exhibits a dual role in promoting oxidative stress and inflammation. This review aims to unravel the intricate connection between these processes and their contribution to AD progression. The review delves into oxidative stress in AD, focusing on the involvement of metals, mitochondrial dysfunction, and

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Bondy, Stephen C., and Shirley X. Guo. "Effect of ethanol treatment on indices of cumulative oxidative stress." European Journal of Pharmacology: Environmental Toxicology and Pharmacology 270, no. 4 (1994): 349–55. http://dx.doi.org/10.1016/0926-6917(94)90011-6.

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K. A., Fasna, Geetha N., and Jean Maliekkal. "Oxidative stress in ageing." International Journal of Research in Medical Sciences 5, no. 11 (2017): 4826. http://dx.doi.org/10.18203/2320-6012.ijrms20174928.

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Background: Ageing is characterized by a gradual decline in body functions and decreased ability to maintain homeostasis. The free radical theory of ageing proposed by Harman D states that ageing is a result of cumulative damage incurred by free radical reactions. Free radicals are highly reactive molecular species with unpaired electrons; generated in the body by several physiological processes. Prime target to free radical attack are the polyunsaturated fatty acids of cell membranes causing lipid peroxidation. The free radicals are neutralized by the exogenous and endogenous antioxidant syst

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van de POLL, Marcel C. G., Cornelis H. C. Dejong, Marc A. J. G. Fischer, Aalt Bast, and Ger H. Koek. "Decreased hepatosplanchnic antioxidant uptake during hepatic ischaemia/reperfusion in patients undergoing liver resection." Clinical Science 114, no. 8 (2008): 553–60. http://dx.doi.org/10.1042/cs20070317.

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Oxidative stress mediates cell injury during ischaemia/reperfusion. On the other hand, experimental findings suggest that ROS (reactive oxygen species) induce processes leading to ischaemic preconditioning. The extent and source of oxidative stress and its effect on antioxidant status in the human liver during intermittent ischaemia and reperfusion remains ill-defined. Therefore the aim of the present study was to investigate the occurrence of oxidative stress in humans undergoing liver resection. Liver biopsies, and arterial and hepatic venous blood samples were taken from ten patients underg

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Cui, Hang, Yahui Kong, and Hong Zhang. "Oxidative Stress, Mitochondrial Dysfunction, and Aging." Journal of Signal Transduction 2012 (October 2, 2012): 1–13. http://dx.doi.org/10.1155/2012/646354.

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Aging is an intricate phenomenon characterized by progressive decline in physiological functions and increase in mortality that is often accompanied by many pathological diseases. Although aging is almost universally conserved among all organisms, the underlying molecular mechanisms of aging remain largely elusive. Many theories of aging have been proposed, including the free-radical and mitochondrial theories of aging. Both theories speculate that cumulative damage to mitochondria and mitochondrial DNA (mtDNA) caused by reactive oxygen species (ROS) is one of the causes of aging. Oxidative da

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Stojiljković, Dragana, Dušica Pavlović, and Ivana Arsić. "Oxidative Stress, Skin Aging and Antioxidant Therapy / Oksidacioni Stres, Starenje Kože I Antioksidaciona Terapija." Acta Facultatis Medicae Naissensis 31, no. 4 (2014): 207–17. http://dx.doi.org/10.2478/afmnai-2014-0026.

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Summary Skin aging is a dynamic process that occurs due to chronological and photo-aging caused by the influence of external factors, especially ultraviolet-UV radiation. Cumulative oxidative stress, formation of free radicals and their adverse effects on biological systems in the skin cells is a common mechanism of both skin aging processes. The formed reactive oxygen species-ROS can lead to the oxidation of cell`s building molecules. Lipid peroxidation, membrane protein damage and DNA mutation may lead to many structural, functional and aesthetic changes in the skin and can also initiate dev

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DANCIU, ADRIAN MARIUS, TIMEA CLAUDIA GHITEA, ALEXA FLORINA BUNGAU, and COSMIN MIHAI VESA. "The Relationship Between Oxidative Stress, Selenium, and Cumulative Risk in Metabolic Syndrome." In Vivo 37, no. 6 (2023): 2877–87. http://dx.doi.org/10.21873/invivo.13406.

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Zaha, Ioana, Mariana Muresan, Camelia Tulcan, et al. "The Role of Oxidative Stress in Infertility." Journal of Personalized Medicine 13, no. 8 (2023): 1264. http://dx.doi.org/10.3390/jpm13081264.

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(1) Background: Oxidative stress markers in the follicular fluid and serum of the patient with IVF results (number of fertilized oocytes, number of embryos, cumulative pregnancy rate) are important in establishing the causes of infertility. (2) Methods: 42 patients were enrolled in the study over the duration of 24 months and were divided into two groups: the study group divided into the female etiology for infertility as a tubal factor, diminished ovarian reserve, endometriosis, and unexplained infertility, and the control group consisting of the male factor, excluding the sperm donors and wi

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Ayubi, N., A. Rusdiawan, S. Hartoto, et al. "Limited impact of roselle flower extract on protein carbonyl levels after physical exercise in healthy men." Medicni perspektivi 30, no. 1 (2025): 117–26. https://doi.org/10.26641/2307-0404.2025.1.325371.

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Exercise-induced oxidative stress can lead to muscle damage, with protein carbonyls serving as a key biomarker of oxidative modification in proteins. Roselle flower extract contains polyphenols with potential antioxidant properties that may reduce oxidative damage after physical exercise. This study investigated whether post-exercise supplementation of roselle flower extract reduces protein carbonyl levels. A randomized controlled trial with a parallel group pre-test/post-test design was conducted, comparing a placebo group with a treatment group receiving 500 mg of roselle flower extract

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Vemula, Surender, Babu Potti Ravindra, and Tiwari Ravindra. "An array of occupationally exposure to extremely low frequency electromagnetic fields and light at night on melatonin and related oxidative stress in human subjects." World Journal of Biology Pharmacy and Health Sciences 12, no. 3 (2022): 291–301. https://doi.org/10.5281/zenodo.7642676.

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During one decade, an increasing percentage of world population has to be attributed to an array of environmental, health and lifestyle factors. The potential effect of extremely low frequency electromagnetic fields (ELF-EMFs) emitted from electrical and various electrical devices in the occupational environment and light at night (LAN) to elicit biological response are a major concern for the public and scientists. Controversial genetic and oxidative stress effects have been reported by these polluted environments. Hence this study was undertaken with a purpose to evaluate melatonin hormone a

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Dr. Swati Rai, Dr Swati Rai, Dr Surendra Yadav Dr.Surendra Yadav, and Vishal Yadav Vishal Yadav. "The Rising Burden of Oxidative Stress in the Modern Era: Pathophysiological Insights into Immunity, Free Radical Formation, and Stress-Induced Cellular Damage." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 1451–55. https://doi.org/10.35629/4494-100214511455.

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Background:Chronic stress has emerged as a widespread health issue in the modern era, contributing significantly to immune suppression and oxidative stress. The imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms plays a pivotal role in the pathogenesis of various chronic diseases. Objective:To explore and synthesize current literature on the relationship between psychological stress, weakened immunity, and the pathophysiological mechanisms underlying oxidative stress and cellular damage. Methods:A comprehensive literature review was conducted using da

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Uțu, Diana, Stelian Pantea, Oana M. Duicu, Danina M. Muntean, and Adrian Sturza. "Contribution of monoamine oxidases to vascular oxidative stress in patients with end-stage renal disease requiring hemodialysis." Canadian Journal of Physiology and Pharmacology 95, no. 11 (2017): 1383–88. http://dx.doi.org/10.1139/cjpp-2017-0067.

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Arteriovenous fistula (AVF) is the “lifeline” for patients with end-stage renal disease (ESRD) undergoing hemodialysis. AVF maturation failure is a poorly understood process, one of the contributors being endothelial dysfunction due to oxidative stress. Monoamine oxidases (MAOs) A and B were recently identified as novel sources of vascular oxidative stress. The aim of the present study was to assess the contribution of MAOs to the endothelial dysfunction in patients with ESDR with indication of hemodialysis. Fragments of brachial artery collaterals were harvested from ESRD patients during the

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Li, Guo-Hui, Yan-Ru Li, Ping Jiao, et al. "Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2-Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action." Oxidative Medicine and Cellular Longevity 2018 (June 27, 2018): 1–13. http://dx.doi.org/10.1155/2018/7309073.

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Oxidative stress plays a central role in the pathogenesis of many human diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating the intracellular antioxidant response and is an emerging target for the prevention and therapy of oxidative stress-related diseases. Salviae Miltiorrhizae Radix et Rhizoma (SMRR) is a traditional Chinese medicine (TCM) and is commonly used for the therapy of cardiac cerebral diseases. Cumulative evidences indicated that the extract of SMRR and its constituents, represented by lipophilic diterpenoid quinones and hydrop

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Phillips, Michael, Felix Grun, and Peter Schmitt. "Breath biomarkers of total body irradiation in non-human primates." Journal of Breath Research 16, no. 2 (2022): 026002. http://dx.doi.org/10.1088/1752-7163/ac39aa.

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Abstract Background. Radiation exposure causes oxidative stress, eliciting production of metabolites that are exhaled in the breath as volatile organic compounds (VOCs). We evaluated breath VOCs as potential biomarkers for use in radiation biodosimetry. Methods. Five anesthetized non-human primates receive total body irradiation (TBI) of three daily fractions of 120 cGy per day for three days, resulting in a cumulative dose of 10.8 Gy. Breath samples were collected prior to irradiation and after each radiation fraction, and analyzed with gas chromatography mass spectrometry. Results. TBI elici

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Vemula Surender, Ravindra Babu Potti, and Ravindra Tiwari. "An array of occupationally exposure to extremely low frequency electromagnetic fields and light at night on melatonin and related oxidative stress in human subjects." World Journal of Biology Pharmacy and Health Sciences 12, no. 3 (2022): 291–301. http://dx.doi.org/10.30574/wjbphs.2022.12.3.0273.

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During one decade, an increasing percentage of world population has to be attributed to an array of environmental, health and lifestyle factors. The potential effect of extremely low frequency electromagnetic fields (ELF-EMFs) emitted from electrical and various electrical devices in the occupational environment and light at night (LAN) to elicit biological response are a major concern for the public and scientists. Controversial genetic and oxidative stress effects have been reported by these polluted environments. Hence this study was undertaken with a purpose to evaluate melatonin hormone a

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17

Kiraly, Michael A., and Stephen J. Kiraly. "The Effect of Exercise on Hippocampal Integrity: Review of Recent Research." International Journal of Psychiatry in Medicine 35, no. 1 (2005): 75–89. http://dx.doi.org/10.2190/hx7l-4b40-pqny-2a4p.

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Objectives: To review salient basic research regarding physical exercise as a major protective factor against hippocampal degradation and to emphasize its relevance to humans. Method: Recent mammalian and human research literature search and theoretical discussion. Results: The cascade of cellular damages from oxidative stress, nitrosative stress and gluco-corticoid effects are cumulative and age related. Exercise training reduces oxidative stress, nitro-sative stress and improves neuroendocrine autoregulation which counteracts damages from stress- and age-related neuronal degeneration, brain

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Minamiyama, Yukiko, Shigekazu Takemura, Hiroshi Ichikawa, and Toshikazu Yoshikawa. "Better understanding the exposome in order to maintain human health." Impact 2022, no. 4 (2022): 20–22. http://dx.doi.org/10.21820/23987073.2022.4.20.

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Cumulative exposure to environmental factors and chemicals can be damaging to human health. A new concept called the exposome refers to the totality of exposures and their impact on health. Professor Yukiko Minamiyama, Food Hygiene and Environmental Health Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, is exploring how lifestyle factors could reduce exposure and maintain human health and also how certain lifestyle changes could control or avoid chronic oxidative stress. She and her team are delving deeper into the concept of

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Bartlett, David, Richard Miller, Scott Thiesfeldt, Hari Lakhani, Joseph Shapiro, and Komal Sodhi. "The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease." International Journal of Molecular Sciences 19, no. 7 (2018): 2139. http://dx.doi.org/10.3390/ijms19072139.

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Aging has been associated with a series of pathophysiological processes causing general decline in the overall health of the afflicted population. The cumulative line of evidence suggests an important role of oxidative stress in the development and progression of the aging process and metabolic abnormalities, exacerbating adipocyte dysfunction, cardiovascular diseases, and associated complications at the same time. In recent years, robust have established the implication of Na/K-ATPase signaling in causing oxidative stress and alterations in cellular mechanisms, in addition to its distinct pum

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Jorgačević, Bojan, Danijela Vučević, Janko Samardžić, et al. "The Effect of CB1 Antagonism on Hepatic Oxidative/Nitrosative Stress and Inflammation in Nonalcoholic Fatty Liver Disease." Current Medicinal Chemistry 28, no. 1 (2020): 169–80. http://dx.doi.org/10.2174/0929867327666200303122734.

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: Dysfunction of the endocannabinoid system (ES) has been identified in nonalcoholic fatty liver disease (NAFLD) and associated metabolic disorders. Cannabinoid receptor type 1 (CB1) expression is largely dependent on nutritional status. Thus, individuals suffering from NAFLD and metabolic syndrome (MS) have a significant increase in ES activity. Furthermore, oxidative/ nitrosative stress and inflammatory process modulation in the liver are highly influenced by the ES. Numerous experimental studies indicate that oxidative and nitrosative stress in the liver is associated with steatosis and por

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Ayubi, N., A. Rusdiawan, S. Hartoto, et al. "Limited impact of roselle flower extract on protein carbonyl levels after physical exercise in healthy men." Medicni perspektivi 30, no. 1 (2025): 117–26. https://doi.org/10.26641/2307-0404.2025.1.325371.

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Abstract:

Exercise-induced oxidative stress can lead to muscle damage, with protein carbonyls serving as a key biomarker of oxidative modification in proteins. Roselle flower extract contains polyphenols with potential antioxidant properties that may reduce oxidative damage after physical exercise. This study investigated whether post-exercise supplementation of roselle flower extract reduces protein carbonyl levels. A randomized controlled trial with a parallel group pre-test/post-test design was conducted, comparing a placebo group with a treatment group receiving 500 mg of roselle flower extract. Th

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Klimek, Angelika, Anna Nowakowska, Hanna Kletkiewicz, et al. "Bidirectional Effect of Repeated Exposure to Extremely Low-Frequency Electromagnetic Field (50 Hz) of 1 and 7 mT on Oxidative/Antioxidative Status in Rat’s Brain: The Prediction for the Vulnerability to Diseases." Oxidative Medicine and Cellular Longevity 2022 (June 14, 2022): 1–14. http://dx.doi.org/10.1155/2022/1031211.

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Studies reported evidence for opposite effects of extremely low-frequency electromagnetic field (EMF): harmful, including the oxidative stress induction, and beneficial, such as the activation of antioxidant defense. People’s exposure to EMF is often repeated or prolonged, and it is important to consider the cumulative effect of such kind of exposure on the organism. If changes evoked by repeated exposure to EMF are permanent, responsiveness to other stress factors can be modified. The aims of our study were (1) to evaluate changes in the levels of oxidative stress and antioxidant defense mark

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Zhang, Zi-Yuan, Xiao-Li Bao, Yun-Yi Cong, Bin Fan, and Guang-Yu Li. "Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress." Oxidative Medicine and Cellular Longevity 2020 (August 8, 2020): 1–13. http://dx.doi.org/10.1155/2020/2896036.

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Age-related macular degeneration (AMD) is a leading cause of severe visual loss and irreversible blindness in the elderly population worldwide. Retinal pigment epithelial (RPE) cells are the major site of pathological alterations in AMD. They are responsible for the phagocytosis of shed photoreceptor outer segments (POSs) and clearance of cellular waste under physiological conditions. Age-related, cumulative oxidative stimuli contribute to the pathogenesis of AMD. Excessive oxidative stress induces RPE cell degeneration and incomplete digestion of POSs, leading to the continuous accumulation o

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Pierro, Federico, Manlio Fazio, Giuseppe Murdaca, Fabio Stagno, Sebastiano Gangemi, and Alessandro Allegra. "Oxidative Stress and Mitochondrial Dysfunction in Myelodysplastic Syndrome: Roles in Development, Diagnosis, Prognosis, and Treatment." International Journal of Molecular Sciences 26, no. 13 (2025): 6415. https://doi.org/10.3390/ijms26136415.

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Myelodysplastic syndromes are a group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, peripheral cytopenia, and dysplasia in one or more myeloid lineages, with a variable risk of progression to acute myeloid leukemia. In addition to well-characterized genetic and epigenetic abnormalities, oxidative stress has emerged as a critical contributor to the pathophysiology of myelodysplastic syndrome. Reactive oxygen species and reactive nitrogen species can induce cumulative DNA damage, mitochondrial dysfunction, and altered redox homeostasis, promoting genomic

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Tripathy, Subrat Kumar, and Pramila Kumari Mishra. "Effect of various cardiovascular risk factors on oxidative stress markers in post menopausal women." International Journal of Basic & Clinical Pharmacology 6, no. 7 (2017): 1768. http://dx.doi.org/10.18203/2319-2003.ijbcp20172746.

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Background: The objectives was to study the association between oxidative stress and various cardiovascular risk factors individually and also there cumulative effect in post-menopausal women.Methods: 50 postmenopausal women with cardiovascular risk factors like hyperglycemia, hypertension, high Body Mass Index and Hyperlipidaemia were selected and burden of various cardiovascular risk factors in them is noted and also compared with 50 age matched apparently healthy post menopausal controls. Malon-di-aldehyde (MDA), vitaminE and vitamin C were taken to assess oxidative stress status. ANOVA was

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Pointner, Angelika, Christine Mölzer, Ulrich Magnet, et al. "The green tea polyphenol EGCG is differentially associated with telomeric regulation in normal human fibroblasts versus cancer cells." Functional Foods in Health and Disease 11, no. 3 (2021): 73. http://dx.doi.org/10.31989/ffhd.v11i3.775.

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Introduction: Topical investigations have demonstrated that oxidative stress and inflammation play key roles in biological aging and determine incidence and course of age-related diseases. Lifestyle and environmental factors hugely impact epigenetic regulation and DNA stability with telomere attrition and epigenetic instability providing a potential record of the cumulative burden of endogenous and exogenous oxidative noxae. Certain physiologically active plant components exhibit antioxidative activities affecting epigenetic regulation of inflammation response and DNA repair.Methods: Against t

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Gateau, Kameelah, Lisa Schlueter, Lara J. Pierce, et al. "Exploratory study evaluating the relationships between perinatal adversity, oxidative stress, and infant neurodevelopment across the first year of life." PLOS Global Public Health 3, no. 12 (2023): e0001984. http://dx.doi.org/10.1371/journal.pgph.0001984.

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Early childhood adversity increases risk for negative lifelong impacts on health and wellbeing. Identifying the risk factors and the associated biological adaptations early in life is critical to develop scalable early screening tools and interventions. Currently, there are limited, reliable early childhood adversity measures that can be deployed prospectively, at scale, to assess risk in pediatric settings. The goal of this two-site longitudinal study was to determine if the gold standard measure of oxidative stress, F2-Isoprostanes, is potentially a reliable measure of a physiological respon

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Bazan-Socha, Stanisława, Krzysztof Wójcik, Magdalena Olchawa, et al. "Increased Oxidative Stress in Asthma—Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices." Biomedicines 10, no. 7 (2022): 1499. http://dx.doi.org/10.3390/biomedicines10071499.

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Airway inflammation in asthma is related to increased reactive oxygen species generation, potentially leading to tissue injury and subsequent airway remodeling. We evaluated oxidative stress in peripheral blood from asthmatic subjects (n = 74) and matched controls (n = 65), using recently developed real-time monitoring of the protein hydroperoxide (HP) formation by the coumarin boronic acid (CBA) assay. We also investigated the relation of the systemic oxidative stress response in asthma to disease severity, lung function, airway remodeling indices (lung computed tomography and histology), and

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Katakami, N., K. Sakamoto, H. Kaneto, et al. "Cumulative Effect of Oxidative Stress-Related Gene Polymorphisms on Myocardial Infarction in Type 2 Diabetes." Diabetes Care 32, no. 5 (2009): e55-e55. http://dx.doi.org/10.2337/dc08-0237.

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Petersen, K. S., and C. Smith. "Ageing-Associated Oxidative Stress and Inflammation Are Alleviated by Products from Grapes." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/6236309.

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Advanced age is associated with increased incidence of a variety of chronic disease states which share oxidative stress and inflammation as causative role players. Furthermore, data point to a role for both cumulative oxidative stress and low grade inflammation in the normal ageing process, independently of disease. Therefore, arguably the best route with which to address premature ageing, as well as age-associated diseases such as diabetes, cardiovascular disease, and dementia, is preventative medicine aimed at modulation of these two responses, which are intricately interlinked. In this revi

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Soler-López, Alejandro, Adrián Moreno-Villanueva, Carlos D. Gómez-Carmona, and José Pino-Ortega. "The Role of Biomarkers in Monitoring Chronic Fatigue Among Male Professional Team Athletes: A Systematic Review." Sensors 24, no. 21 (2024): 6862. http://dx.doi.org/10.3390/s24216862.

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This systematic review synthesizes evidence on biomarker responses to physiological loads in professional male team sport athletes, providing insights into induced fatigue states. Structured searches across major databases yielded 28 studies examining various biomarkers in elite team sport players. Studies evaluated muscle damage markers, anabolic/catabolic hormones reflecting metabolic strain, inflammatory markers indicating immune activity and tissue damage, immunological markers tied to infection risk, and oxidative stress markers showing redox imbalances from excessive physiological load.

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Azarang, Aein, Omid Farshad, Mohammad Mehdi Ommati, et al. "Protective Role of Probiotic Supplements in Hepatic Steatosis: A Rat Model Study." BioMed Research International 2020 (November 22, 2020): 1–15. http://dx.doi.org/10.1155/2020/5487659.

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Background. Treating nonalcoholic fatty liver disease (NAFLD) is considered one of the public health priorities in the past decade. So far, probiotics have represented promising results in controlling the signs and symptoms of NAFLD. However, attempts to find the ideal probiotic strain are still ongoing. The present study is designed to find the best strain amongst suitable probiotic strains according to their ability to ameliorate histopathological and oxidative stress biomarkers in hepatic steatosis-induced rats. Methods. Initially, four probiotics species, including Lactobacillus (L.) acido

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Bruells, Christian S., Karen Maes, Rolf Rossaint, et al. "Sedation Using Propofol Induces Similar Diaphragm Dysfunction and Atrophy during Spontaneous Breathing and Mechanical Ventilation in Rats." Anesthesiology 120, no. 3 (2014): 665–72. http://dx.doi.org/10.1097/aln.0000000000000125.

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Abstract Background: Mechanical ventilation is crucial for patients with respiratory failure. The mechanical takeover of diaphragm function leads to diaphragm dysfunction and atrophy (ventilator-induced diaphragmatic dysfunction), with an increase in oxidative stress as a major contributor. In most patients, a sedative regimen has to be initiated to allow tube tolerance and ventilator synchrony. Clinical data imply a correlation between cumulative propofol dosage and diaphragm dysfunction, whereas laboratory investigations have revealed that propofol has some antioxidant properties. The author

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Rawson, G., M. Pase, M. Howard, and M. Jackson. "P026 Obstructive sleep apnoea as a risk factor for Alzheimer’s Disease pathogenesis: a literature review and proposal of a novel model of neuropathological pathways." Sleep Advances 5, Supplement_1 (2024): A38. https://doi.org/10.1093/sleepadvances/zpae070.108.

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Abstract Background Obstructive sleep apnoea (OSA) is a common sleep disorder that has been associated with an increased risk of Alzheimer’s disease (AD). Potential mechanistic pathways in this relationship include hypertension and oxidative stress (the imbalance of antioxidants and reactive oxygen species incurred by hypoxemia). Recently, the role of sleep microarchitecture has been investigated both as a consequence of OSA, and as a potential contributor to AD pathogenesis. Aims The aim of this literature review is to integrate findings pertaining to OSA as a potential risk factor for AD pat

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Zou, Runmei, Shuo Wang, Hong Cai, Yuwen Wang та Cheng Wang. "Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway". Cardiovascular Therapeutics 2023 (22 лютого 2023): 1–12. http://dx.doi.org/10.1155/2023/2108584.

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Background. Doxorubicin-induced cardiotoxicity has been closely concerned in clinical practice. Rev-erbα is a transcriptional repressor that emerges as a drug target for heart diseases recently. This study is aimed at investigating the role and mechanism of Rev-erbα in doxorubicin-induced cardiotoxicity. Methods. H9c2 cells were treated with 1.5 μM doxorubicin, and C57BL/6 mice were treated with a 20 mg/kg cumulative dose of doxorubicin to construct doxorubicin-induced cardiotoxicity models in vitro and in vivo. Agonist SR9009 was used to activate Rev-erbα. PGC-1α expression level was downregu

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Akolkar, Gauri, Danielle da Silva Dias, Prathapan Ayyappan, et al. "Vitamin C mitigates oxidative/nitrosative stress and inflammation in doxorubicin-induced cardiomyopathy." American Journal of Physiology-Heart and Circulatory Physiology 313, no. 4 (2017): H795—H809. http://dx.doi.org/10.1152/ajpheart.00253.2017.

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Increase in oxidative/nitrosative stress is one of the mechanisms associated with the development of cardiotoxicity due to doxorubicin (Dox), a potent chemotherapy drug. Previously, we reported mitigation of Dox-induced oxidative/nitrosative stress and apoptosis by vitamin C (Vit C) in isolated cardiomyocytes. In the present in vivo study in rats, we investigated the effect of prophylactic treatment with Vit C on Dox-induced apoptosis, inflammation, oxidative/nitrosative stress, cardiac dysfunction, and Vit C transporter proteins. Dox (cumulative dose: 15 mg/kg) in rats reduced systolic and di

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Obrador, Elena, Feng Liu-Smith, Ryan W. Dellinger, Rosario Salvador, Frank L. Meyskens, and José M. Estrela. "Oxidative stress and antioxidants in the pathophysiology of malignant melanoma." Biological Chemistry 400, no. 5 (2019): 589–612. http://dx.doi.org/10.1515/hsz-2018-0327.

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Abstract The high number of somatic mutations in the melanoma genome associated with cumulative ultra violet (UV) exposure has rendered it one of the most difficult of cancers to treat. With new treatment approaches based on targeted and immune therapies, drug resistance has appeared as a consistent problem. Redox biology, including reactive oxygen and nitrogen species (ROS and RNS), plays a central role in all aspects of melanoma pathophysiology, from initiation to progression and to metastatic cells. The involvement of melanin production and UV radiation in ROS/RNS generation has rendered th

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Saxena, Rahul, Shilpa Suneja, Raj Saxena, Dilutpal Sharma, and Alok Milton Lal. "Cumulative effect of systemic inflammation and oxidative stress in 40 known cases of active rheumatoid arthritis." International Journal of Research in Orthopaedics 1, no. 1 (2015): 7. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20160341.

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<p class="abstract"><strong>Background:</strong> Oxidative stress has been implicated in the pathophysiology of a number of diseases such as cancer, hypertension and inflammatory diseases. Although previous evidences provided extensive literature about the biological role of antioxidant enzymes in rheumatoid arthritis (RA), there is a paucity of satisfactory explanation regarding the alteration in the level of antioxidant enzymes along with marker of systemic inflammation in RA. The objective of present study was to estimate the level of C-reactive protein (CRP), Superoxide d

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Howard, A. B., R. W. Alexander, R. M. Nerem, K. K. Griendling, and W. R. Taylor. "Cyclic strain induces an oxidative stress in endothelial cells." American Journal of Physiology-Cell Physiology 272, no. 2 (1997): C421—C427. http://dx.doi.org/10.1152/ajpcell.1997.272.2.c421.

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Hypertension imposes an oxidant stress on the aorta and also causes mechanical deformation of the aortic wall. To assess whether deformation causes an oxidative stress, isolated porcine aortic endothelial cells (PAEC) were subjected to cyclic strain, and the cumulative amount of thiobarbituric acid reactive substances (TBARS, an index of lipid peroxidation) and H2O2 (a reactive oxygen species) was measured in the eluent at 2, 6, and 24 h. TBARS were increased by 40.5 +/- 9.2% after 24 h in cells exposed to cyclic strain vs. static controls (P < 0.05). No difference was seen at 2 and 6 h. H2

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Simsek, Kemal, Hakan Ay, Turgut Topal, et al. "Long-term exposure to repetitive hyperbaric oxygen results in cumulative oxidative stress in rat lung tissue." Inhalation Toxicology 23, no. 3 (2011): 166–72. http://dx.doi.org/10.3109/08958378.2011.558528.

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Ortíz, Genaro Gabriel, Ana Laura Briones-Torres, Gloria Benitez-King, Luis Javier González-Ortíz, Claudia Verónica Palacios-Magaña та Fermín Paul Pacheco-Moisés. "Beneficial Effect of Melatonin Alone or in Combination with Glatiramer Acetate and Interferon β-1b on Experimental Autoimmune Encephalomyelitis". Molecules 27, № 13 (2022): 4217. http://dx.doi.org/10.3390/molecules27134217.

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Experimental autoimmune encephalomyelitis (EAE) is a relevant animal model of multiple sclerosis (MS). Oxidative stress and chronic inflammation play a major role in the pathogenesis of MS and EAE. Melatonin, a neurohormone, has potent anti-inflammatory properties. The aim of our study was to assess the therapeutic properties of melatonin alone or in combination with interferon β-1b (IFNβ-1b) or glatiramer acetate (GA) on EAE. EAE was induced in male Sprague-Dawley rats with an intraperitoneal injection of a homogenate of spinal cord and pig brain. At day 10 post immunization, rats were euthan

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Chandrasekar, B., J. F. Nelson, J. T. Colston, and G. L. Freeman. "Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury." American Journal of Physiology-Heart and Circulatory Physiology 280, no. 5 (2001): H2094—H2102. http://dx.doi.org/10.1152/ajpheart.2001.280.5.h2094.

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The life-prolonging effects of calorie restriction (CR) may be due to reduced damage from cumulative oxidative stress. Our goal was to determine the long-term effects of moderate dietary CR on the myocardial response to reperfusion after a single episode of sublethal ischemia. Male Fisher 344 rats were fed either an ad libitum (AL) or CR (40% less calories) diet. At age 12 mo the animals were anaesthetized and subjected to thoracotomy and a 15-min left-anterior descending coronary artery occlusion. The hearts were reperfused for various periods. GSH and GSSG levels, nuclear factor-κB (NF-κB) D

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Kumar, Vinay, Hemavathy S, Lohith Kumar Dasarahally Huligowda, et al. "Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health." Biomedicines 13, no. 1 (2025): 241. https://doi.org/10.3390/biomedicines13010241.

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Comorbidities related to cardiovascular disease (CVD) and environmental pollution have emerged as serious concerns. The exposome concept underscores the cumulative impact of environmental factors, including climate change, air pollution, chemicals like PFAS, and heavy metals, on cardiovascular health. Chronic exposure to these pollutants contributes to inflammation, oxidative stress, and endothelial dysfunction, further exacerbating the global burden of CVDs. Specifically, carbon monoxide (CO), ozone, particulate matter (PM2.5), nitrogen dioxide (NO2), sulfur dioxide (SO2), heavy metals, pesti

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Spanò, Carmelina, Stefania Bottega, Lorenza Bellani, Simonetta Muccifora, Carlo Sorce, and Monica Ruffini Castiglione. "Effect of Zinc Priming on Salt Response of Wheat Seedlings: Relieving or Worsening?" Plants 9, no. 11 (2020): 1514. http://dx.doi.org/10.3390/plants9111514.

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In an attempt to alleviate salt-induced damage, the application of ZnO nanoparticles has been suggested. As the use of these particles has also been associated with phytotoxicity, to better clarify the effect of zinc and its possible mitigation of salt stress, we treated wheat seedlings with ZnO (nanoparticles or their bulk-scale counterparts, amended either in the growth medium, NPs and B, or sprayed on the leaves, SPNPs and SPB) with or without subsequent treatment with salt. Growth, photosynthetic parameters, zinc and ion concentration, and in situ and biochemical determination of oxidative

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Kumar, K. Jagadish, Smriti Bhagiratha, and Prashanth Vishwanath. "Evaluation of Ischaemia Modified Albumin as a Marker of Oxidative Stress in Beta Thalassemia Major Children." Journal of Nepal Paediatric Society 41, no. 1 (2021): 61–66. http://dx.doi.org/10.3126/jnps.v41i1.29931.

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    Introduction: Iron overload in thalassemia catalyses the production of a variety of reactive oxygen species leading to cumulative cell damage. Ischemia modified albumin (IMA) is an end product of oxidative stress. It is imperative to pick up oxidative stress early in order to prevent the organ damage in thalassemia. Therefore this study was undertaken to estimate IMA levels and to see the correlation between ferritin and IMA to establish whether ferritin can be a proxy marker for oxidative stress. Methods: A total of 76 children were included in the study out

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Yoon, Somy, Gwang Hyeon Eom, and Gaeun Kang. "Nitrosative Stress and Human Disease: Therapeutic Potential of Denitrosylation." International Journal of Molecular Sciences 22, no. 18 (2021): 9794. http://dx.doi.org/10.3390/ijms22189794.

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Proteins dynamically contribute towards maintaining cellular homeostasis. Posttranslational modification regulates the function of target proteins through their immediate activation, sudden inhibition, or permanent degradation. Among numerous protein modifications, protein nitrosation and its functional relevance have emerged. Nitrosation generally initiates nitric oxide (NO) production in association with NO synthase. NO is conjugated to free thiol in the cysteine side chain (S-nitrosylation) and is propagated via the transnitrosylation mechanism. S-nitrosylation is a signaling pathway freque

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Fonseca, Lucas José Sá da, Valéria Nunes-Souza, Marília Oliveira Fonseca Goulart, and Luiza Antas Rabelo. "Oxidative Stress in Rheumatoid Arthritis: What the Future Might Hold regarding Novel Biomarkers and Add-On Therapies." Oxidative Medicine and Cellular Longevity 2019 (December 16, 2019): 1–16. http://dx.doi.org/10.1155/2019/7536805.

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Numerous rheumatologic autoimmune diseases, among which rheumatoid arthritis, are chronic inflammatory diseases capable of inducing multiple cumulative articular and extra-articular damage, if not properly treated. Nevertheless, benign conditions may, similarly, exhibit arthritis as their major clinical finding, but with short-term duration instead, and evolve to spontaneous resolution in a few days to weeks, without permanent articular damage. Such distinction—self-limited arthritis with no need of immunosuppressive treatment or chronic arthritis at early stages?—represents one of the greates

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Djuric, Zora, Chloe E. Bird, Alice Furumoto-Dawson, et al. "Biomarkers of Psychological Stress in Health Disparities Research." Open Biomarkers Journal 1, no. 1 (2008): 7–19. http://dx.doi.org/10.2174/1875318300801010007.

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Psychological stress can contribute to health disparities in populations that are confronted with the recurring stress of everyday life. A number of biomarkers have been shown to be affected by psychological stress. These biomarkers include allostatic load, which is a summary measure of the cumulative biological burden of the repeated attempts to adapt to daily stress. Allostatic load includes effects on the hypothalamic-pituitary axis, the sympathetic nervous system and the cardiovascular system. These in turn affect the immune system via bidirectional signaling pathways. Evidence is also bui

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Rhind, Shawn G., Maria Y. Shiu, Oshin Vartanian, et al. "Neurological Biomarker Profiles in Royal Canadian Air Force (RCAF) Pilots and Aircrew." Brain Sciences 14, no. 12 (2024): 1296. https://doi.org/10.3390/brainsci14121296.

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Background/Objectives: Military aviators can be exposed to extreme physiological stressors, including decompression stress, G-forces, as well as intermittent hypoxia and/or hyperoxia, which may contribute to neurobiological dysfunction/damage. This study aimed to investigate the levels of neurological biomarkers in military aviators to assess the potential risk of long-term brain injury and neurodegeneration. Methods: This cross-sectional study involved 48 Canadian Armed Forces (CAF) aviators and 48 non-aviator CAF controls. Plasma samples were analyzed for biomarkers of glial activation (GFAP

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Olorundare, Olufunke, Adejuwon Adeneye, Akinyele Akinsola, et al. "African Vegetables (Clerodendrum volibile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats." Oxidative Medicine and Cellular Longevity 2020 (October 14, 2020): 1–15. http://dx.doi.org/10.1155/2020/9535426.

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Trastuzumab (TZM) is a humanized monoclonal antibody that has been approved for the clinical management of HER2-positive metastatic breast and gastric cancers but its use is limited by its cumulative dose and off-target cardiotoxicity. Unfortunately, till date, there is no approved antidote to this off-target toxicity. Therefore, an acute study was designed at investigating the protective potential and mechanism(s) of CVE and IGE in TZM-induced cardiotoxicity utilizing cardiac enzyme and oxidative stress markers and histopathological endpoints. 400 mg/kg/day CVE and IGE dissolved in 5% DMSO in

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