Relevant bibliographies by topics / CUP1

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'CUP1'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

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Journal articles on the topic "CUP1"

1

Knight, S. A., K. T. Tamai, D. J. Kosman, and D. J. Thiele. "Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein." Molecular and Cellular Biology 14, no. 12 (1994): 7792–804. http://dx.doi.org/10.1128/mcb.14.12.7792-7804.1994.

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Yeast metallothionein, encoded by the CUP1 gene, and its copper-dependent transcriptional activator ACE1 play a key role in mediating copper resistance in Saccharomyces cerevisiae. Using an ethyl methanesulfonate mutant of a yeast strain in which CUP1 and ACE1 were deleted, we isolated a gene, designated CUP9, which permits yeast cells to grow at high concentrations of environmental copper, most notably when lactate is the sole carbon source. Disruption of CUP9, which is located on chromosome XVI, caused a loss of copper resistance in strains which possessed CUP1 and ACE1, as well as in the cup1 ace1 deletion strain. Measurement of intracellular copper levels of the wild-type and cup9-1 mutant demonstrated that total intracellular copper concentrations were unaffected by CUP9. CUP9 mRNA levels were, however, down regulated by copper when yeast cells were grown with glucose but not with lactate or glycerol-ethanol as the sole carbon source. This down regulation was independent of the copper metalloregulatory transcription factor ACE1. The DNA sequence of CUP9 predicts an open reading frame of 306 amino acids in which a 55-amino-acid sequence showed 47% identity with the homeobox domain of the human proto-oncogene PBX1, suggesting that CUP9 is a DNA-binding protein which regulates the expression of important copper homeostatic genes.
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Knight, S. A., K. T. Tamai, D. J. Kosman, and D. J. Thiele. "Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein." Molecular and Cellular Biology 14, no. 12 (1994): 7792–804. http://dx.doi.org/10.1128/mcb.14.12.7792.

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Yeast metallothionein, encoded by the CUP1 gene, and its copper-dependent transcriptional activator ACE1 play a key role in mediating copper resistance in Saccharomyces cerevisiae. Using an ethyl methanesulfonate mutant of a yeast strain in which CUP1 and ACE1 were deleted, we isolated a gene, designated CUP9, which permits yeast cells to grow at high concentrations of environmental copper, most notably when lactate is the sole carbon source. Disruption of CUP9, which is located on chromosome XVI, caused a loss of copper resistance in strains which possessed CUP1 and ACE1, as well as in the cup1 ace1 deletion strain. Measurement of intracellular copper levels of the wild-type and cup9-1 mutant demonstrated that total intracellular copper concentrations were unaffected by CUP9. CUP9 mRNA levels were, however, down regulated by copper when yeast cells were grown with glucose but not with lactate or glycerol-ethanol as the sole carbon source. This down regulation was independent of the copper metalloregulatory transcription factor ACE1. The DNA sequence of CUP9 predicts an open reading frame of 306 amino acids in which a 55-amino-acid sequence showed 47% identity with the homeobox domain of the human proto-oncogene PBX1, suggesting that CUP9 is a DNA-binding protein which regulates the expression of important copper homeostatic genes.
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3

Wimalarathna, Roshini N., Po Yun Pan, and Chang-Hui Shen. "Co-dependent recruitment of Ino80p and Snf2p is required for yeast CUP1 activation." Biochemistry and Cell Biology 92, no. 1 (2014): 69–75. http://dx.doi.org/10.1139/bcb-2013-0097.

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In yeast, Ace1p-dependent induction of CUP1 is responsible for protecting cells from copper toxicity. Although the mechanism of yeast CUP1 induction has been studied intensively, it is still uncertain which chromatin remodelers are involved in CUP1 transcriptional activation. Here, we show that yeast cells are inviable in the presence of copper when either chromatin remodeler, Ino80p or Snf2p, is not present. This inviability is due to the lack of CUP1 expression in ino80Δ and snf2Δ cells. Subsequently, we observe that both Ino80p and Snf2p are present at the promoter and they are responsible for recruiting chromatin remodeling activity to the CUP1 promoter under induced conditions. These results suggest that they directly participate in CUP1 transcriptional activation. Furthermore, the codependent recruitment of both INO80 and SWI/SNF depends on the presence of the transcriptional activator, Ace1p. We also demonstrate that both remodelers are required to recruit RNA polymerase II and targeted histone acetylation, indicating that remodelers are recruited to the CUP1 promoter before RNA polymerase II and histone acetylases. These observations provide evidence for the mechanism of CUP1 induction. As such, we propose a model that describes novel insight into the order of events in CUP1 activation.
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Shen, Chang-Hui, Benoit P. Leblanc, Carolyn Neal, Ramin Akhavan, and David J. Clark. "Targeted Histone Acetylation at the Yeast CUP1 Promoter Requires the Transcriptional Activator, the TATA Boxes, and the Putative Histone Acetylase Encoded by SPT10." Molecular and Cellular Biology 22, no. 18 (2002): 6406–16. http://dx.doi.org/10.1128/mcb.22.18.6406-6416.2002.

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ABSTRACT The relationship between chromatin remodeling and histone acetylation at the yeast CUP1 gene was addressed. CUP1 encodes a metallothionein required for cell growth at high copper concentrations. Induction of CUP1 with copper resulted in targeted acetylation of both H3 and H4 at the CUP1 promoter. Nucleosomes containing upstream activating sequences and sequences farther upstream were the targets for H3 acetylation. Targeted acetylation of H3 and H4 required the transcriptional activator (Ace1p) and the TATA boxes, suggesting that targeted acetylation occurs when TATA-binding protein binds to the TATA box or at a later stage in initiation. We have shown previously that induction results in nucleosome repositioning over the entire CUP1 gene, which requires Ace1p but not the TATA boxes. Therefore, the movement of nucleosomes occurring on CUP1 induction is independent of targeted acetylation. Targeted acetylation of both H3 and H4 also required the product of the SPT10 gene, which encodes a putative histone acetylase implicated in regulation at core promoters. Disruption of SPT10 was lethal at high copper concentrations and correlated with slower induction and reduced maximum levels of CUP1 mRNA. These observations constitute evidence for a novel mechanism of chromatin activation at CUP1, with a major role for the TATA box.
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Buchman, C., P. Skroch, W. Dixon, T. D. Tullius, and M. Karin. "A single amino acid change in CUP2 alters its mode of DNA binding." Molecular and Cellular Biology 10, no. 9 (1990): 4778–87. http://dx.doi.org/10.1128/mcb.10.9.4778-4787.1990.

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CUP2 is a copper-dependent transcriptional activator of the yeast CUP1 metallothionein gene. In the presence of Cu+ and Ag+) ions its DNA-binding domain is thought to fold as a cysteine-coordinated Cu cluster which recognizes the palindromic CUP1 upstream activation sequence (UASc). Using mobility shift, methylation interference, and DNase I and hydroxyl radical footprinting assays, we examined the interaction of wild-type and variant CUP2 proteins produced in Escherichia coli with the UASc. Our results suggest that CUP2 has a complex Cu-coordinated DNA-binding domain containing different parts that function as DNA-binding elements recognizing distinct sequence motifs embedded within the UASc. A single-amino-acid substitution of cysteine 11 with a tyrosine results in decreased Cu binding, apparent inactivation of one of the DNA-binding elements and a dramatic change in the recognition properties of CUP2. This variant protein interacts with only one part of the wild-type site and prefers to bind to a different half-site from the wild-type protein. Although the variant has about 10% of wild-type DNA-binding activity, it appears to be completely incapable of activating transcription.
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Buchman, C., P. Skroch, W. Dixon, T. D. Tullius, and M. Karin. "A single amino acid change in CUP2 alters its mode of DNA binding." Molecular and Cellular Biology 10, no. 9 (1990): 4778–87. http://dx.doi.org/10.1128/mcb.10.9.4778.

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CUP2 is a copper-dependent transcriptional activator of the yeast CUP1 metallothionein gene. In the presence of Cu+ and Ag+) ions its DNA-binding domain is thought to fold as a cysteine-coordinated Cu cluster which recognizes the palindromic CUP1 upstream activation sequence (UASc). Using mobility shift, methylation interference, and DNase I and hydroxyl radical footprinting assays, we examined the interaction of wild-type and variant CUP2 proteins produced in Escherichia coli with the UASc. Our results suggest that CUP2 has a complex Cu-coordinated DNA-binding domain containing different parts that function as DNA-binding elements recognizing distinct sequence motifs embedded within the UASc. A single-amino-acid substitution of cysteine 11 with a tyrosine results in decreased Cu binding, apparent inactivation of one of the DNA-binding elements and a dramatic change in the recognition properties of CUP2. This variant protein interacts with only one part of the wild-type site and prefers to bind to a different half-site from the wild-type protein. Although the variant has about 10% of wild-type DNA-binding activity, it appears to be completely incapable of activating transcription.
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7

Thiele, D. J. "ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene." Molecular and Cellular Biology 8, no. 7 (1988): 2745–52. http://dx.doi.org/10.1128/mcb.8.7.2745-2752.1988.

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Copper resistance in Saccharomyces cerevisiae is mediated, in large part, by the CUP1 locus, which encodes a low-molecular-weight, cysteine-rich metal-binding protein. Expression of the CUP1 gene is regulated at the level of transcriptional induction in response to high environmental copper levels. This report describes the isolation of a yeast mutant, ace1-1, which is defective in the activation of CUP1 expression upon exposure to exogenous copper. The ace1-1 mutation is recessive and lies in a genetic element that encodes a trans-acting CUP1 regulatory factor. The wild-type ACE1 gene was isolated by in vivo complementation and restores copper inducibility of CUP1 expression and copper resistance to the otherwise copper-sensitive ace1-1 mutant. Linkage analysis and gene deletion experiments verified that this gene represents the authentic ACE1 locus. ACE1 maps to the left arm of chromosome VII, 9 centimorgans centromere distal to lys5. The ACE1 gene appears to play a direct or indirect positive role in activation of CUP1 expression in response to elevated copper concentrations.
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Silar, P., G. Butler, and D. J. Thiele. "Heat shock transcription factor activates transcription of the yeast metallothionein gene." Molecular and Cellular Biology 11, no. 3 (1991): 1232–38. http://dx.doi.org/10.1128/mcb.11.3.1232-1238.1991.

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In the yeast Saccharomyces cerevisiae, transcription of the metallothionein gene CUP1 is induced by copper and silver. Strains with a complete deletion of the ACE1 gene, the copper-dependent activator of CUP1 transcription, are hypersensitive to copper. These strains have a low but significant basal level of CUP1 transcription. To identify genes which mediate basal transcription of CUP1 or which activate CUP1 in response to other stimuli, we isolated an extragenic suppressor of an ace1 deletion. We demonstrate that a single amino acid substitution in the heat shock transcription factor (HSF) DNA-binding domain dramatically enhances CUP1 transcription while reducing transcription of the SSA3 gene, a member of the yeast hsp70 gene family. These results indicate that yeast metallothionein transcription is under HSF control and that metallothionein biosynthesis is important in response to heat shock stress. Furthermore, our results suggest that HSF may modulate the magnitude of individual heat shock gene transcription by subtle differences in its interaction with heat shock elements and that a single-amino-acid change can dramatically alter the activity of the factor for different target genes.
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Silar, P., G. Butler, and D. J. Thiele. "Heat shock transcription factor activates transcription of the yeast metallothionein gene." Molecular and Cellular Biology 11, no. 3 (1991): 1232–38. http://dx.doi.org/10.1128/mcb.11.3.1232.

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In the yeast Saccharomyces cerevisiae, transcription of the metallothionein gene CUP1 is induced by copper and silver. Strains with a complete deletion of the ACE1 gene, the copper-dependent activator of CUP1 transcription, are hypersensitive to copper. These strains have a low but significant basal level of CUP1 transcription. To identify genes which mediate basal transcription of CUP1 or which activate CUP1 in response to other stimuli, we isolated an extragenic suppressor of an ace1 deletion. We demonstrate that a single amino acid substitution in the heat shock transcription factor (HSF) DNA-binding domain dramatically enhances CUP1 transcription while reducing transcription of the SSA3 gene, a member of the yeast hsp70 gene family. These results indicate that yeast metallothionein transcription is under HSF control and that metallothionein biosynthesis is important in response to heat shock stress. Furthermore, our results suggest that HSF may modulate the magnitude of individual heat shock gene transcription by subtle differences in its interaction with heat shock elements and that a single-amino-acid change can dramatically alter the activity of the factor for different target genes.
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10

Thiele, D. J. "ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene." Molecular and Cellular Biology 8, no. 7 (1988): 2745–52. http://dx.doi.org/10.1128/mcb.8.7.2745.

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Abstract:
Copper resistance in Saccharomyces cerevisiae is mediated, in large part, by the CUP1 locus, which encodes a low-molecular-weight, cysteine-rich metal-binding protein. Expression of the CUP1 gene is regulated at the level of transcriptional induction in response to high environmental copper levels. This report describes the isolation of a yeast mutant, ace1-1, which is defective in the activation of CUP1 expression upon exposure to exogenous copper. The ace1-1 mutation is recessive and lies in a genetic element that encodes a trans-acting CUP1 regulatory factor. The wild-type ACE1 gene was isolated by in vivo complementation and restores copper inducibility of CUP1 expression and copper resistance to the otherwise copper-sensitive ace1-1 mutant. Linkage analysis and gene deletion experiments verified that this gene represents the authentic ACE1 locus. ACE1 maps to the left arm of chromosome VII, 9 centimorgans centromere distal to lys5. The ACE1 gene appears to play a direct or indirect positive role in activation of CUP1 expression in response to elevated copper concentrations.
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Dissertations / Theses on the topic "CUP1"

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Meyer, Jennifer L. "P-element-mediated transformation of Drosophila melanogaster with the yeast metallothionein gene CUP1 to assess the potential for genetic improvement of beneficial insects in Florida citrus." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010296.

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Crosato, Giulia. "Genomic variations in Saccharomyces cerevisiae populations: diffusion in vineyards and effect on vinification processes." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425400.

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The project of this doctoral thesis arisen from a previous work of vineyard yeast isolation, collection and characterization, which was held at the Wine Microbiology laboratory of the University of Padova in Conegliano (CIRVE). Some genomic variations have been uncovered thanks to the genome sequencing of four S. cerevisiae strains. The relationship between the yeast genotype and phenotype is one of the most debated topics in wine microbiology. Aimed to trying deepening the knowledge regarding the genomic variations effects on the oenological performances of wine yeasts, this thesis is focused on the diffusion of some genomic variations in vineyard yeasts populations and on their implications on the strains technological phenotype. The oenological characterization of Brazilian Saccharomyces cerevisiae yeast strains has been performed, paying attention to the link between the local agricultural practices and the strains biodiversity in vineyard. Results showed that the heavy use of Cu in plant protection contributed to develop a strong Cu tolerance in the autochthonous population. This effect didn’t affect the strains genotype biodiversity so those vineyards were confirmed as great reservoir for wine yeast strains isolation and selection. The strains Cu and SO2 tolerance has been studied on Italian and Brazilian S. cerevisiae vineyard strains. The studied topics were the relationship between the CUP1 Copy N° Variation and the Cu tolerance and the relationship between the presence of two chromosomal translocations and the SO2 tolerance. Results evidenced an association between genetic traits and tolerant phenotypes at vineyard population level, in particular for Cu tolerance and the CUP1 CNV. Moreover, hints of an association between Cu and SO2 tolerance are discussed. The fermentable carbon sources uptake in 4 S. cerevisiae strains has been investigated. The expression of the hexose transporters genes has been analysed during stationary phase of synthetic must fermentation. The study involved FSY1, found in EC1118 and encoding for a high affinity fructose/H+ symporter, present in the 25% of the vineyard strains. Gene expression analysis evidenced that strain-specificity is not related to a single gene but it depends on the main regulation pathways. The higher utilization of FSY1 by P301.9 and R31.3 seems counterbalancing their higher glucose preference during fermentation. The FSY1 putative role in wine yeast seems to be its acting as helper of more effective carbon sources utilization at the latest fermentation stages. This work can contribute in improving the wine yeasts characterization by giving a tool for their distinction for fitness in the winemaking environment, at transcriptional level. Lastly, S. cerevisiae strains EC1118 and QA23have been studied under the Martinotti’s method for sparkling wine production. The yeast cells viability during the pied-de-cuve preparation, the pressure evolution in autoclave and the cells response to the wine chilling at the end of the second fermentation were taken into account. During the wine chilling, cells have been recovered for the total RNA extraction to be used in transcriptomic analysis. Preliminary results show that EC1118 has been characterized by lower cells viability than QA23 since the ethanol adaptation procedure and all along the fermentative process. This difference reflected to the pressure evolution kinetic. Data of the total RNA extraction, quantification, integrity and quality check are also presented.<br>Il progetto di questa tesi di dottorato nasce da un precedente lavoro di isolamento, raccolta e caratterizzazione di lieviti da vigneto. Alcune variazioni genomiche sono state scoperte grazie al sequenziamento del genoma di quattro ceppi S. cerevisiae. La relazione tra genotipo e fenotipo nel lievito è uno degli argomenti più dibattuti in enologia. Con l’obiettivo di approfondire la conoscenza riguardo alle possibili conseguenze delle variazioni genomiche sulle prestazioni enologiche dei lieviti, questa tesi si concentra sulla diffusione di alcune variazioni genomiche nelle popolazioni di lieviti di vigneto e sulle loro implicazioni sul fenotipo tecnologico del lievito. È stata caratterizzata una popolazione di ceppi brasiliani della specie Saccharomyces cerevisiae, prestando attenzione al legame tra le pratiche agricole locali e la biodiversità dei ceppi in vigneto. I risultati hanno mostrato che l’importante uso del rame nella protezione della vite ha contribuito a sviluppare una forte tolleranza a questo metallo nella popolazione di lieviti autoctona. Questo effetto non ha influenzato la biodiversità genotipica dei ceppi di lievito nei vigneti interessati, che si sono stati confermati un’importante riserva per l’isolamento e la selezione dei ceppi di lievito enologici. La tolleranza verso il rame e i solfiti è stata studiata tra i ceppi S. cerevisiae delle collezioni di lieviti italiani e brasiliani. Gli argomenti trattati hanno riguardato il rapporto tra il CUP1 CNV (Copy N° Variation), e il rapporto tra la tolleranza al rame e la presenza di due traslocazioni cromosomiche e la tolleranza ai solfiti. I risultati hanno evidenziato un'associazione tra i tratti genetici e i fenotipi tolleranti a livello di popolazione di vigneto, in particolare tra la tolleranza al rame e il CUP1 CNV. È inoltre discussa la possibile associazione tra la tolleranza al rame e quella ai solfiti. È stato studiato l'assorbimento delle fonti di carbonio fermentabili in 4 ceppi S. cerevisiae. L'espressione genica dei trasportatori di esosi è stata analizzata durante la fase stazionaria della fermentazione in mosto sintetico. Lo studio ha coinvolto FSY1, gene trovato in EC1118 codificante per un simporto ad alta affinità fruttosio/H+, presente nel 25% dei ceppi di vigneto. L'analisi dell'espressione genica ha evidenziato che la ceppo-specificità non è correlata a un singolo gene ma dipende dalle vie principali di regolazione. Il maggiore utilizzo di FSY1 da parte di P301.9 e R31.3 sembra controbilanciare la loro elevata preferenza per il glucosio durante la fermentazione. Il ruolo di FSY1 nel lievito enologico sembra essere quello di aiuto per l'utilizzo più efficiente delle fonti di carbonio nelle ultime fasi fermentative. Questo lavoro può contribuire alla caratterizzazione dei lieviti enologici dando uno strumento per la loro distinzione per il fitness nell'ambiente di vinificazione a livello trascrizionale. Infine, i ceppi EC1118 e QA23 sono stati studiati in spumantizzazione secondo il metodo Martinotti, utilizzato nella produzione del Prosecco DOC Spumante (Conegliano-Valdobbiadene). È stato valutato la vitalità delle cellule di lievito durante la preparazione del pied-de-cuve, l'evoluzione di pressione in autoclave e la risposta delle cellule al raffreddamento del vino a fine processo. Durante il raffreddamento forzato le cellule sono state campionate per l'estrazione del RNA totale per la successiva analisi trascrittomica. I risultati preliminari mostrano che EC1118 è stato caratterizzato da una vitalità cellulare sempre inferiore rispetto a QA23, dalla fase di adattamento all'etanolo e per tutto il processo. Questa differenza si riflette sulla cinetica di evoluzione della pressione. Sono inoltre presentati e discussi i dati riguardanti l’estrazione, quantificazione, integrità e verifica della qualità del RNA totale.
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Hull, Ryan. "Accelerated adaptation through stimulated copy number variation in Saccharomyces cerevisiae." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284381.

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Accelerated Adaptation through Stimulated Copy Number Variation in Saccharomyces cerevisiae Ryan Matthew Hull Repetitive regions of the genome, such as the centromeres, telomeres and ribosomal DNA account for a large proportion of the genetic variation between individuals. Differences in the number of repeat sequences between individuals is termed copy number variation (CNV) and is rife across eukaryotic genomes. CNV is of clinical importance as it has been implicated in many human disorders, in particularly cancers where is has been associated with tumour growth and drug resistance. The copper-resistance gene CUP1 in Saccharomyces cerevisiae is one such CNV gene. CUP1 is transcribed from a copper inducible promoter and encodes a protein involved in copper detoxification. In this work I show that yeast can regulate their repeat levels of the CUP1 gene through a transcriptionally stimulated CNV mechanism, as a direct adaptation response to a hostile environment. I characterise the requirement of the epigenetic mark Histone H3 Lysine 56 acetylation (H3K56ac) for stimulated CNV and its limitation of only working at actively transcribed genes. Based upon my findings, I propose a model for how stimulated CNV is regulated in yeast and show how we can pharmacologically manipulate this mechanism using drugs, like nicotinamide and rapamycin, to stimulate and repress a cell's ability to adapt to its environment. I further show that the model is not limited to high-copy CUP1 repeat arrays, but is also applicable to low-copy systems. Finally, I show that the model extends to other genetic loci in response to different challenging environments, such as formaldehyde stimulation of the formaldehyde-resistance gene SFA1. To the best of our knowledge, this is the first example of any eukaryotic cell undergoing genome optimisation as a novel means to accelerate its adaptation in direct response to its environment. If conserved in higher eukaryotes, such a mechanism could have major implications in how we consider and treat disorders associated with changes in CNV.
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Sivaneson, Melissa. "Caractérisation des systèmes à deux composants Roc chez Pseudomonas aeruginosa : un reseau de régulation complexe." Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX22117.

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Pseudomonas aeruginosa est une bactérie à Gram négatif à caractère ubiquitaire que l’on retrouve dans une grande diversité d’environnements. C’est un pathogène opportuniste qui est responsable chez l’homme d’infections chroniques ou aigües qui peuvent être mortelles pour des patients immuno-déficients. L’établissement d’une infection chronique est généralement associé à la capacité de la bactérie à former un biofilm, qui se définit comme une population bactérienne attachée sur une surface et englobée par une matrice extracellulaire formée entre autre depolysaccharides. La formation du biofilm est un processus bien défini dans le temps et dans l’espace et qui implique la mise en jeu de nombreuses structures de surfaces dont l’assemblage est strictement contrôlé. Une des voies de régulation contrôlant cet assemblage est le système à 2composants Roc1 (« regulation of cup genes »). Les gènes cup codent des composants de la voie « chaperone-usher » qui permet le transport de sous-unités pilines et leur assemblage à la surface bactérienne sous forme de pili. Ces pili Cup sont important dans l’établissement du biofilm. Le système Roc1 est aussi impliqué dans la mise en place du système de sécrétion de type III, qui est communément associé aux infections aigues. De fait le système Roc1 peut être considéré comme un «interrupteur» décidant du mode d’infection associé à P. aeruginosa. Le système Roc1 est constitué d’un senseur non-orthodoxe (RocS1) et de deux régulateurs de réponse, RocA1 et RocR, dont le domaine effecteur est un domaine de liaison à l’ADN ou un domaine EAL à activité phosphodiesterase, respectivement. Il existe également d’autres gènes paralogues de Roc1 qui sont le système Roc2 avec RocS2 et RocA2 très similaire à RocS1 et RocA1, ainsi que RocS3 similaire à RocS1. Le travail réalisé au cours de ma thèse a montré qu’il existe une régulation croisée entre Roc1 etRoc2. Cependant, chacune des branches du réseau de régulation contrôle l’expression d’une série de gènes bien spécifiques. Nous avons montré que la signalisation via RocS2 et RocS1 lorsqu’elle converge sur RocA1 contrôle l’expression des gènes cupC et ce contrôle est totalement indépendantde RocA2. Par contre lorsque la signalisation RocS1 et RocS2 converge vers RocA2 alors ce sont les gènes mexAB-oprM, qui codent une pompe d’efflux impliquée dans la résistance aux antibiotiques, dont l’expression est alors réprimée.En conclusion, nous avons mis en évidence un modèle unique de régulation croisée qui résulte dans un effet antagoniste entre formation du biofilm et résistance aux antibiotiques. Si cela peut paraître inattendu, quelques données cliniques sont en faveur d’une telle balance. En effet, l’analyse de souches de P. aeruginosa, isolées à partir de patients atteints de mucoviscidose, révèle que dans ces isolats la pompe MexAB-OprM est inactive. La raison de cette adaptation n’est pas élucidée, mais l’absence de pompe fonctionnelle pourrait procurer un avantage, une meilleure aptitude à la souche à persister dans cet environnement. Il est également reconnu que dans les poumons de ces patients le mode préféré de développement pour P. aeruginosa est le biofilm. Mises bout à bout ces observations suggèrent donc que le système Roc pourrait être un système de régulation important pour percevoir l’environnement du poumon chez le patient mucoviscidosique et déclencher une réponse adaptée<br>The opportunistic pathogen Pseudomonas aeruginosa is responsible for diverse chronic and acute infections in human. Chronic infections are associated with the capacity of P. aeruginosa to form biofilms. One of the pathways controlling biofilm formation is the Roc1 two-component system, involved in the regulation of cup genes allow the assembly of thin fimbriae at the surface of the bacterium. Cup fimbiae are important in biofilm formation. There exist paralogues of the Roc1 system - the Roc2 and Roc3 system. The work in this thesis has shown that cross-regulation occurs between Roc1 and Roc2. However, each branch in this network appears to control the expression of a specific subset of genes whose role and functions are striking in the context of an infection process. We characterized here a unique model of cross-regulation which results in the antagonistic regulation of biofilm formation and antibiotic resistance
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Linder, Kelli Marie. "A Comparative Analysis of Two Prototype Smart Training Cups: An Iterative Process." Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1461948535.

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Siskovich, Kristen M. "A Novel Method for Evaluating Flow Rates, Posture, and Bolus Size During Open-Cup Drinking in Children." Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1461952523.

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7

Ehrig, Matthias. "Drucken mit CUPS." Universitätsbibliothek Chemnitz, 2001. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200100326.

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Gemeinsamer Workshop von Universitaetsrechenzentrum und Professur "Rechnernetze und verteilte Systeme" der Fakultaet fuer Informatik der TU Chemnitz. Workshop-Thema: Mobilitaet Der Vortrag stellt das Common UNIX Printing System vor, das auf dem neuen Internet Printing Protokol Standard IPP beruht und diskutiert Einsatzmöglichkeiten im URZ der TU Chemnitz
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Jahre, Daniel. "CUPS - KOnfiguration und Programmierung." Universitätsbibliothek Chemnitz, 2001. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200100421.

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In diesem Vortrag werden die Konfigurationswerkzeuge des Common Unix Printing Systems (CUPS) beispielhaft erläutert. Außerdem wird die Konfiguration von CUPS anhand der Konfigurationsdateien beschrieben. Die Progranmmierung von CUPS wird anhand der Programmiersprache C gezeigt.
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Kiefer, John. "Sacred containers/sacred cups." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1129631.

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Since the 1960s, following the dramatic changes in the Roman Catholic Church, the design of the chalices used at the communion service became simplified; many of them becoming so plain that they are only wine goblets devoid of any decoration. As Catholics implement the changes of the Second Vatican Council, we have a growing desire for sacred vessels that better reflect a sense of awe.The purpose of this creative project is to explore symbolism used in chalice design. Traditional and newer symbols are incorporated into the chalices produced in this project.My creative process involves a community of people. Teachers, fellow students, friends and members of my church shared their knowledge, ideas and insights to enrich the final products.The sense of the sacred is not limited to God because God is present within each person. To be aware of the sacred in my own designs I need to be in touch with the sacred within me.<br>Department of Art
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Núñez, Ramos Patricia, and del Hombre Bueno Mérida Juan Romero. "Developent of a Vending Cup.- Mistral Vending Cup." Thesis, University of Skövde, School of Technology and Society, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3478.

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<p>This is a Bachelor Degree Project report based on the design of a plastic vending cup.The project is carried out in cooperation with the company Promens Lidköping,manufacturer of a wide range of plastic products as food packaging, trays, pots, cups andsheets for the food industry.</p><p>A vending cup is a product used to contain hot beverages which come from vendingcoffee machines. It is a product daily used in many different environments as hospitals,offices, libraries and common places, etc. Consequently it is aimed at a varied public.</p><p>The redesign was focused mainly on the aesthetics aspect attempting to transmit aninnovative touch that would change the concept of today’s simple vending cup in a waythat it attracts the customer’s attention.</p><p>The so called Mistral Vending Cup is a plastic cup which is out of the ordinary currentvending cup by means of a new bright colour, orange, and also its innovative shape, inthis field, constituted basically from organic lines and curve surfaces unlike the today’svending cups. The Mistral Vending cup introduces a great change, a new era in thehistory of the vending cups due to its organic shapes never seen in the market.</p>
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Books on the topic "CUP1"

1

1958-, McCarra Kevin, ed. 100 cups: The story of the Scottish Cup. Mainstream in conjunction with Scottish Brewers, 1985.

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Anderson, Keith. North & South Cups: Scottish Qualifying Cup (North) and Scottish Qualifying Cup (South) : review of 1984/85 competitions. (K. Anderson), 1985.

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Hernandez, Jo Farb. Irvin Tepper, when cups speak: Life with the cup ; a 25-year survey. Natalie and James Thompson Art Gallery, School of Art and Design, San Jos State Univ., 2003.

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Hernandez, Jo Farb. Irvin Tepper: When cups speak : life with the cup : a 25-year survey. San José State University, 2002.

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Hernandez, Jo Farb. Irvin Tepper, when cups speak: Life with the cup : a 25-year survey. Natalie and James Thompson Gallery, School of Art and Design, San José State University, 2002.

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Myall, Julia. Cook it in a cup!: Quick meals and treats kids can cook in silicone cups! Chronicle Books, 2007.

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Goodman, Willy April, ed. Three cups. Three Cups, 2007.

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Favilla, Candice. Cups: Poems. University of Georgia Press, 1992.

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Connor, Nikki. Plastic cups. Copper Beech Books, 1996.

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Mark, St Germain, and Willy April Goodman ill, eds. Three cups. Tommy Nelson, 2011.

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Book chapters on the topic "CUP1"

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Fogel, S., J. W. Welch, and D. H. Moloney. "Meiotic Copy Number Changes at CUP1 r are Mediated by Gene Conversion." In Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74197-5_26.

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Welch, J., and S. Fogel. "The Yeast CUP1 Gene: A Model for Biological Detoxification of Heavy Metal Effluents." In Environmental Biotechnology. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-0824-7_66.

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Welch, J. W., D. H. Maloney, and Seymour Fogel. "Synaptic Relations in Meiotic Gene Conversion at the Iterated CUP1 r Locus of S. Cerevisiae." In Experientia Supplementum. Birkhäuser Basel, 1987. http://dx.doi.org/10.1007/978-3-0348-6784-9_42.

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Hasegawa, Isao, Emiko Terada, Michio Sunairi, et al. "Genetic improvement of heavy metal tolerance in plants by transfer of the yeast metallothionein gene (CUP1)." In Plant Nutrition for Sustainable Food Production and Environment. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-009-0047-9_117.

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Abramovits, William. "Cups." In Dermatological Cryosurgery and Cryotherapy. Springer London, 2016. http://dx.doi.org/10.1007/978-1-4471-6765-5_17.

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Beverland, David. "Cups." In The Corail® Hip System. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-18396-6_8.

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Villars, P., K. Cenzual, J. Daams, et al. "CuPt." In Structure Types. Part 5: Space Groups (173) P63 - (166) R-3m. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-46933-9_359.

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Bruno, E., and B. Ginatempo. "Electronic Topological Transitions and Compositional Order in CuPd and CuPt Alloys." In Properties of Complex Inorganic Solids. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5943-6_39.

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Sarangi, Srikant. "Culture." In Handbook of Pragmatics. John Benjamins Publishing Company, 1996. http://dx.doi.org/10.1075/hop.1.cul1.

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Kelly, Dorothy. "Curriculum." In Handbook of Translation Studies. John Benjamins Publishing Company, 2010. http://dx.doi.org/10.1075/hts.1.cur1.

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Conference papers on the topic "CUP1"

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Wang, Xiaofeng, Yuzhen Lin, Haosheng Hu, Chi Zhang, and Yao Kang. "Effect of Swirl Cup’s Venturi Shape on Spray Structure and Ignition Process." In ASME Turbo Expo 2014: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/gt2014-25216.

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In a gas turbine engine combustor, combustion performance is tied to the spatial distribution of the fuel injected into the dome. Swirl cup, as an air blast atomizer, is widely used to provide a uniform presentation of fuel droplets to the combustor dome. In this paper, two swirl cups with different venturi angle have been studied: case 1 (with narrow venturi angle) and case 2 (with wide venturi angle). Kerosene is injected to the test domain through a simplex nozzle. The spatial distribution of droplet characteristics produced by the two swirl cups were measured using dual-phase Doppler anemometry (PDA). A single cup combustor has been built in order to characterize the swirl cups’ ignition phenomena. Spark ignition test has been performed for ground condition, two swirl cups’ lean ignition limits are obtained, and ignition sequences have been recorded by a high-speed video camera. Comparing the two swirl cups’ small droplets velocity, case 1 swirl cup produces a different velocity profile from typical swirl cup. The air stream outflowing from case 1 swirl cup just ran into the side wall. The droplet size around the spark plug of case 2 is smaller than case 1. Ignition test results show that case 2 swirl cup’s lean ignition limit is wider than case 1’s. Record of the ignition process deepened the understanding of spark ignition of the swirl diffusion flame. It takes some time for the kernel to anchor in swirl cup. The results demonstrate that swirl cup’s venturi shape strongly influence the spray structure. Thereby affect the combustor ignition performance.
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Chen, Yng-Ru, Michael Hölling, and J. Iwan D. Alexander. "Characterization of Cup Anemometer Dynamics." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-87480.

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Cup anemometers are most commonly used for measuring wind speeds in the atmospheric boundary layer, among others for site assessment. The simple design of a cup anemometer consists of three cups mounted on a vertical shaft. Due to the difference in the drag coefficient of the open and the closed side of the cups the system is rotating, where the rotational frequency is proportional to the incoming wind speed. One downside of cup anemometers is their asymmetric dynamic response to accelerating and decelerating wind speeds under turbulent wind conditions. This asymmetry results in a systematic overestimation under turbulent wind conditions, the so-called over-speeding [3][4][5]. The goal of the presented experiments is to characterize the dynamical response of cup anemometers for decreasing wind velocities in particular. Additionally, the effect of different torques and an unbalanced system on the anemometer’s dynamics is investigated by adding rare earth magnets as weights to the cups. These characteristics are basis for the post processing of measured data under turbulent wind conditions. Regions of the measured time series that are dominated by the specific dynamics of the cup anemometer are therefore affected by over-speeding and should be excluded from further analysis. Systematic changes in the anemometer’s dynamics on the other hand, are indicators for damages e.g. wear of bearings or contamination of the cups [6].
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Maggi, Carmelo, Jan Wojnar, and Leonardo Tognarelli. "All-Purpose Packing Cups for Hyper Compressor." In ASME 2016 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/pvp2016-63256.

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Hyper compressors are designed for LDPE production, compressing ethylene up to 3500bar with only two stages of compression, in order to reach conditions for the polymerization. The high operating and fluctuating pressure strongly impact design and life of all cylinder components. The packing cups are among the most stressed components of a hyper compressor cylinder. They are particularly subjected to very high pulsating pressures, thus fatigue and wear. Therefore, they are periodically replaced during maintenance and are critical for availability of the hyper compressor. A typical hyper compressor packing assembly contains 5 to 6 disc shaped packing cups that contain the plunger sealing rings at the internal diameter. The packing cups are provided with lube oil ducts to lubricate the sealing elements. Typically these ducts extend axially through the assembly to the injection points. For that purpose each packing cup could have a different number of lube oil passages. Moreover, at the external diameter are located passages for packing cooling oil. For these reasons each of the packing cups is a unique part with different machining features. In order to optimize the availability of spare parts and standardize the product, a new design of hyper compressor packing cups has been evaluated, called further “all-purpose packing cup”. The idea was to make the packing cups all equal to each other, and potentially to reduce manufacturing and warehousing costs. This idea has been realized by introducing in a single all-purpose cup, multiple sectors angularly offset with each other. Each sector contains the oil ducts required for a given cup position in the assembly. By rotating the cup about the plunger axis by e.g. 90° or 180° the desired sector can be activated (put in fluid communication with adjacent lube oil ducts). In this way the “all-purpose packing cup” can be mounted in each of the 5 to 6 different positions in the packing assembly. The all-purpose cup design has been analyzed by a well validated FEA approach on the high cycle fatigue and flaw propagation safety margins. The analysis was performed considering all multiple possible load combinations where, depending on the assembly configuration, different active lube oil holes (holes that deliver oil to the plunger) were pressurized while all remaining ducts were left unpressurized.
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Karuppannan, Srinivasan, Bhirud Mehul, Gullapalli Sivaramakrishna, Raju D. Navindgi, and N. Muthuveerappan. "CFD Analyses of Flow in a Gas Turbine Combustor Swirl Cup." In ASME 2017 Gas Turbine India Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/gtindia2017-4725.

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Swirl cups (hybrid atomizers) are being widely employed in aero gas turbine engine combustors for their established merits in terms of achieving satisfactory atomization over the entire combustor operating regime. Even though several investigators have worked on development of these swirl cups, there is a scanty data reported in literature relevant to their design. In the present study, flow behavior in a swirl cup assembled in a confined chamber similar to a gas turbine combustor has been analyzed. Flow analysis has been carried out using ANSYS Fluent and turbulence has been modeled using Realizable k-ϵ model. Six swirl cup configurations have been analyzed; mass flow ratio between primary and secondary swirler and venturi converging area ratio have been varied. The effect of these parameters on downstream flow field has been studied by analyzing the profiles of axial, tangential and radial velocities downstream of swirl cup. The size and shape of the recirculation zone has been analyzed and reported for all configurations. Also, the mass flow recirculated by swirl cup has been estimated and compared amongst the configurations analyzed. Data thus generated is very useful in designing such swirl cups of gas turbine combustors.
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Kang, Lu, Alison L. Galvin, Zhongmin Jin, and John Fisher. "Modelling the Effects of Head Diameter and Cup Wall Thickness on Contact Mechanics and Wear of Cross-Linked UHMWPE Cups." In World Tribology Congress III. ASMEDC, 2005. http://dx.doi.org/10.1115/wtc2005-63474.

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A three-dimensional contact-coupled wear model was developed and used to predict the long-term wear in both conventional and cross-linked ultra high molecular weight polyethylene (UHMWPE) cups, particular to examine the effect of the head diameter and the UHMWPE cup wall thickness. The wear factors were determined from the simulator testing of 28 mm diameter cups. The maximum contact pressure was found to decrease with the increase of head diameter up to 48 mm, corresponding to the decrease in the cup wall thickness for a fixed outside diameter of the cup. Volumetric wear rate was predicted to increase as the head size increased for the conventional UHMWPE, as well as the cross-linked UHMWPE, although at a much lower rate for the latter due to the smaller wear factor.
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Jedenmalm, Anneli, Walther Leardini, Mara Zavalloni, and Saverio Affatato. "Effect of Head Surface Roughness and Sterilization Method on Wear of UHMWPE Acetabular Cups: Preliminary Hip Joint Simulator Results." In ASME 8th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2006. http://dx.doi.org/10.1115/esda2006-95512.

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More than one million hip joint replacements are performed each year in the world. However, the implants do not last forever due to material limitations, even though the operation is successful. The most common material combination used today is a CoCr head articulating against an UHMWPE (Ultra High Molecular Weight Polyethylene) acetabular cup. Several investigations have shown that the metal head is roughened inside the body and thus accelerating wear of the polymer cup. The sterilization method is also known to have effect on the wear properties. In vitro wear tests are however usually performed with as new implants. This investigation aimed at study the impact of head surface roughness on wear of both sterilized and non-sterilized acetabular cups. A total of nine acetabular cup and head pairs were wear tested in a hip joint simulator for 2Million cycles (Mc) with bovine calf serum as lubricant. Wear was determined by weighing of all cups. The heads were of CoCrMo and the average initial head surface roughness was 15nm (Ra), measured with a white light interference profilometer. The roughening was produced with a SiC paper producing circular multidirectional wear tracks to a surface roughness of about 400nm (Ra). The cups were of UHMWPE and the sterilized cups were 3Mrad gamma-radiated in nitrogen. The surface roughness after wear test was unchanged for the roughened heads, while the initially smooth heads were slightly roughened. Preliminary results show that the rough heads increase the wear of the cups 2-fold. The γ-irradiation affected both wear- and soak rate.
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Zhang, Hang, Jinhui Dong, Can Cui, and Ningsheng Liao. "Effect of Interference on Stress and Strain Distribution on the Spherical Sealing Cup of a PIG in Dented Pipeline." In ASME 2019 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/pvp2019-93037.

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Abstract Regular pigging operation of the pipeline inspection gauges (PIGs) is crucial for pipeline transportation. However, the PIG is often stuck when it runs in the oil and gas pipeline due to the interaction between spherical sealing cup and dent inside the pipe. The stress and strain distribution of the outer edge of the spherical sealing cup can provide a reference to the problem of understanding the blockage. In this study, numerical simulation of a PIG with spherical sealing cups runs through a pipe with dented wall is presented using MSC Marc 2016. Effects of the interference (δ) of the spherical sealing cup on the stress and strain distribution on the outer edge of the cup were discussed based on the model. Simulation results indicate that the smaller the thickness of the spherical sealing cup, the greater the effect of the interference of the cup on the stress. And the thickness of the cup should not be too small, an example of the failure of pigging due to the small thickness of the cup and the increase in the interference is given. The conclusions obtained in this study can contribute to the optimization design of the PIGs.
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Campo, Nicola, and Francesco Chiesi. "Improved Design for Hypercompressor Packing Cups." In ASME 2007 Pressure Vessels and Piping Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/pvp2007-26269.

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Second stage cylinders for polyethylene hyper compressors are among the most stressed pressure vessels in the industry. Due to the high operating pressure and pressure fluctuations between suction and discharge, these cylinders must be designed to withstand high fatigue loads. Packing cups are the most critical cylinder component and, in particular, the lube oil ducts are the bottleneck for reliability. This work deals with a structural optimization of packing cups focused on the most critical packing cup area: the lube oil hole. Various pre-compression techniques (i.e., shrink-fit and autofrettage) are used to improve the fatigue behavior. Longer life and reliability are investigated with advanced design techniques such as finite element modeling and design of experiments. New design cups with a 50% higher fatigue safety factor have been obtained.
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Kuan, Ta-Wen, Shih-Pang Tseng, Jhing-Fa Wang, and Pin-Jie Chen. "A happiness cups system for holding-cup motion recognition and warming-care delivery." In 2016 International Conference on Orange Technologies (ICOT). IEEE, 2016. http://dx.doi.org/10.1109/icot.2016.8278968.

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Takahashi, Koji, Yohei Ito, and Tatsuya Ikuta. "A Graphene Chain Acts as a Long-Distance Ballistic Heat Conductor." In 2010 14th International Heat Transfer Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/ihtc14-22289.

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A carbon nanofiber material, consisting of bottomless graphene cups inside on each other in a line, like a set of soft-drink cups, has been discovered to have the potential to conduct heat ballistically over a long distance. Its longitudinal heat transport ability had been forecast to be extremely poor due to the weak van der Waals force operating between the graphene cups, but our measurements using nano thermal sensor showed that its thermal conductivity is much higher than that along the c-axis of bulk graphite. This unexpected result can be understood by its similarity to a one-dimensional (1D) harmonic-chain where no phonon is scattered even for an infinite length. The current graphene-based nanofiber resembles this type of “superconductive” chain due to the huge difference between the stiff covalent bonding in each cup and the weak inter-cup interaction. A non-equilibrium molecular dynamics simulation is conducted to explore the phonon transport in this fiber. The simulation results show that the thermal conductivity varies with the fiber length in a power law fashion with an exponent as large as 0.7. The calculated phonon density of states and atomic motions indicate that a low-frequency quasi-1D oscillation occurs there. Our investigations show that treating the current nanofiber as a 1D chain with three-dimensional oscillations explains well why this material has the most effective ballistic phonon transport ever observed.
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Reports on the topic "CUP1"

1

Luther, Jamie, Holly Goodson, and Clint Arnett. Development of a genetic memory platform for detection of metals in water : use of mRNA and protein destabilization elements as a means to control autoinduction from the CUP1 promoter of Saccharomyces cerevisiae. Construction Engineering Research Laboratory (U.S.), 2018. http://dx.doi.org/10.21079/11681/27275.

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Brenden, B. B. Test of dip cup instrumentation. Office of Scientific and Technical Information (OSTI), 1988. http://dx.doi.org/10.2172/6873207.

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Fernandes, Huston. Faraday's Cup Design and Testing. Office of Scientific and Technical Information (OSTI), 2015. http://dx.doi.org/10.2172/1505101.

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Witkover R. L. and Z.-G. Li. The HITL Faraday Cup Amplifier. Office of Scientific and Technical Information (OSTI), 1985. http://dx.doi.org/10.2172/1151140.

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Eppich, G., R. Kips, and R. Lindvall. Compilation of LLNL CUP-2 Data. Office of Scientific and Technical Information (OSTI), 2016. http://dx.doi.org/10.2172/1325861.

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Monroe, Deirdre Christina. Exploding Bridgewire Cup Loading and Density Control. Office of Scientific and Technical Information (OSTI), 2013. http://dx.doi.org/10.2172/1095198.

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Lee, Wellington K., Tyler Jake Morris, Andrew Chun-An Chu, Joshua Russ, and Michelle Emerson-Lewis. UVI ThunnderBird Cup v2.0 Workshop: Worshop Analysis 2016. Office of Scientific and Technical Information (OSTI), 2016. http://dx.doi.org/10.2172/1334944.

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Ulrich, G. B., A. T. Woods, and E. K. Ohriner. Clad vent set cup closure-weld-zone grinding evaluation. Office of Scientific and Technical Information (OSTI), 1996. http://dx.doi.org/10.2172/441744.

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Naca, Christine. The Power of Teamwork: Winning the 2007 Ergo Cup. Office of Scientific and Technical Information (OSTI), 2007. http://dx.doi.org/10.2172/919397.

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Lee, Wellington K., Tyler Morris, Andrew Chu, Katrina Gilmore, Joshua Russ, and Aliyah Carter. ABQ ThunderBird Cup v3.0 Alpha Worksop: Workshop Analysis 2016. Office of Scientific and Technical Information (OSTI), 2016. http://dx.doi.org/10.2172/1334945.

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