To see the other types of publications on this topic, follow the link: Curcumin - Antimalarial.

Journal articles on the topic 'Curcumin - Antimalarial'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 45 journal articles for your research on the topic 'Curcumin - Antimalarial.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Jamil, Siti Nur Hidayah, Amatul Hamizah Ali, Shevin Rizal Feroz, et al. "Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action." Pharmaceuticals 16, no. 4 (2023): 609. http://dx.doi.org/10.3390/ph16040609.

Full text
Abstract:
Curcumin, one of the major ingredients of turmeric (Curcuma longa), has been widely reported for its diverse bioactivities, including against malaria and inflammatory-related diseases. However, curcumin’s low bioavailability limits its potential as an antimalarial and anti-inflammatory agent. Therefore, research on the design and synthesis of novel curcumin derivatives is being actively pursued to improve the pharmacokinetic profile and efficacy of curcumin. This review discusses the antimalarial and anti-inflammatory activities and the structure–activity relationship (SAR), as well as the mechanisms of action of curcumin and its derivatives in malarial treatment. This review provides information on the identification of the methoxy phenyl group responsible for the antimalarial activity and the potential sites and functional groups of curcumin for structural modification to improve its antimalarial and anti-inflammatory actions, as well as potential molecular targets of curcumin derivatives in the context of malaria and inflammation.
APA, Harvard, Vancouver, ISO, and other styles
2

Astuti, Endang, Tri Joko Raharjo, Putra Boang Manalu, Ilham Satria Putra, Stephanus Satria Waskitha, and Junita Solin. "Synthesis, Molecular Docking, and Evaluation of Some New Curcumin Analogs as Antimalarial Agents." Indonesian Journal of Chemistry 21, no. 2 (2021): 452. http://dx.doi.org/10.22146/ijc.57646.

Full text
Abstract:
This research involves the synthesis, antimalarial evaluation, and molecular docking of several curcumin analogs. A total of six curcumin analog compounds were synthesized using aldol condensation using hydrochloric acid and sodium hydroxide catalysts. The synthesized compounds were elucidated using FTIR, 1H-NMR, 13C-NMR, and LC-MS/MS. Subsequently, all curcumin analogs were tested as an antimalarial agent against Plasmodium falciparum 3D7 strain, and their mechanism of action was evaluated through a molecular docking study. Six curcumin analogs, i.e. 2,6-bis(2-hydroxybenzylidene)cyclohexanone; 2,6-bis(2-hydroxybenzylidene)cyclopentanone; 1.5-bis(2-hydroxyphenyl)penta-1,4-diene-3-one; 2,6-bis(3-hydroxybenzylidene)cyclo-hexanone; 2,6-bis(3-hydroxybenzylidene)cyclopentanone; and 1,5-bis(3-hydroxy-phenyl)penta-1,4-diene-3-one have been successfully synthesized. In addition, 2,6-bis(2-hydroxybenzylidene) cyclopentanone demonstrated the lowest IC50 value and binding affinity of 0.04 µM and -7.6 kcal/mol, respectively. Based on molecular docking studies, this compound also showed the most potent antimalarial activity targeted at PfATP6.
APA, Harvard, Vancouver, ISO, and other styles
3

Costa da Silva, Milena, Michele Dayane Rodrigues Leite, Suelem Sonaly Lima Oliveira, Thiago Bizerra Fideles, and Marcus Vinícius Lia Fook. "Morphological Evaluation of Chitosan/Curcumin Beads and Powder: Effect of the Methanol as a Solvent." Materials Science Forum 869 (August 2016): 854–58. http://dx.doi.org/10.4028/www.scientific.net/msf.869.854.

Full text
Abstract:
Curcumin is a polyphenolic component of Curcuma longa, highlighting in the literature by presenting medicinal properties such as: antioxidant, anti-inflammatory, antibacterial, antiparasitic, antimalarial and anticancer activities. From this, it has been used together with curcumin, chitosan, a biodegradable polymer of natural origin, in order to encapsulate curcumin from a polymer system. Thus, this study aimed to evaluate the morphological behavior of beads and powder chitosan/curcumin, by the Optical Microscopy (OM) technique in the presence of the solvent (methanol). From the pictures, it was noticed that the beads have in their external structure the presence of the drug in a punctual manner, but a more homogeneous internal region. Regarding the powder, it was observed that curcumin was well distributed and involved by chitosan, proving the good interaction between them. In the presence of the solvent, the beads and the powder showed a good distribution of curcumin.
APA, Harvard, Vancouver, ISO, and other styles
4

Khairani, Shafia, Nisa Fauziah, Hesti Lina Wiraswati, et al. "Piperine Enhances the Antimalarial Activity of Curcumin in Plasmodium berghei ANKA-Infected Mice: A Novel Approach for Malaria Prophylaxis." Evidence-Based Complementary and Alternative Medicine 2022 (September 5, 2022): 1–11. http://dx.doi.org/10.1155/2022/7897163.

Full text
Abstract:
Malaria is a prevalent vector-borne infectious disease in tropical regions, particularly in the absence of effective vaccines and because of the emergence resistance of Plasmodium to available antimalarial drugs. An alternative strategy for malaria eradication could be the combination of existing compounds that possess antimalarial activity to target multiple stages of the parasite. This study evaluated the antimalarial activity of a combination of curcumin and piperine in mice. A total of 42 mice were assigned to six groups depending on the treatment administered: group I (normal group) with aquadest; group II (negative control) with 0.2 ml DMSO; group III received a standard malarial drug (artesunate 5 mg/kg BW); groups IV, V, and VI with curcumin 300 mg/kg BW, curcumin 300 mg/kg BW and piperine 20 mg/kg BW, and piperine 20 mg/kg BW, respectively. The antimalarial activity was evaluated using prophylactic assays in Plasmodium berghei ANKA-infected mice, including the percentage parasitemia, clinical signs, survival rate, serum biochemical analysis, parasitic load in the liver, and liver histopathology. All treatments showed significant ( p < 0.05 ) antiplasmodial activity, with considerable parasite inhibition (>50%), curcumin 300 mg/kg BW (60.22%), curcumin 300 mg/kg BW, and piperine 20 mg/kg BW (77.94%) except for piperine 20 mg/kg BW (47.20%), eliciting greater inhibition relative to that of artesunate (51.18%). The delayed onset of clinical symptoms and prolonged survival rate were also significant ( p < 0.05 ) in the combination of curcumin and piperine treated group. In addition, the low parasitic load in the liver and mild histopathological changes in the liver suggest that the combination of curcumin and piperine had synergistic or additive effects. These findings demonstrate the promising use of these combined compounds as a malarial prophylactic. Further studies were recommended to assess their clinical usefulness.
APA, Harvard, Vancouver, ISO, and other styles
5

Mishra, Kirti, Aditya P. Dash, and Nrisingha Dey. "Andrographolide: A Novel Antimalarial Diterpene Lactone Compound fromAndrographis paniculataand Its Interaction with Curcumin and Artesunate." Journal of Tropical Medicine 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/579518.

Full text
Abstract:
Andrographolide (AND), the diterpene lactone compound, was purified by HPLC from the methanolic fraction of the plantAndrographis paniculata. The compound was found to have potent antiplasmodial activity when tested in isolation and in combination with curcumin and artesunate against the erythrocytic stages ofPlasmodium falciparum in vitroandPlasmodium bergheiANKAin vivo. IC50s for artesunate (AS), andrographolide (AND), and curcumin (CUR) were found to be 0.05, 9.1 and 17.4 μM, respectively. The compound (AND) was found synergistic with curcumin (CUR) and addictively interactive with artesunate (AS).In vivo, andrographolide-curcumin exhibited better antimalarial activity, not only by reducing parasitemia (29%), compared to the control (81%), but also by extending the life span by 2-3 folds. Being nontoxic to thein vivosystem this agent can be used as template molecule for designing new derivatives with improved antimalarial properties.
APA, Harvard, Vancouver, ISO, and other styles
6

Neto, Zoraima, Marta Machado, Ana Lindeza, Virgílio do Rosário, Marcos L. Gazarini, and Dinora Lopes. "Treatment ofPlasmodium chabaudiParasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System." Journal of Parasitology Research 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/429736.

Full text
Abstract:
Antimalarial drug resistance remains a major obstacle in malaria control. Evidence from Southeast Asia shows that resistance to artemisinin combination therapy (ACT) is inevitable. Ethnopharmacological studies have confirmed the efficacy of curcumin againstPlasmodiumspp. Drug interaction assays between curcumin/piperine/chloroquine and curcumin/piperine/artemisinin combinations and the potential of drug treatment to interfere with the ubiquitin proteasome system (UPS) were analyzed.In vivoefficacy of curcumin was studied in BALB/c mice infected withPlasmodium chabaudiclones resistant to chloroquine and artemisinin, and drug interactions were analyzed by isobolograms. Subtherapeutic doses of curcumin, chloroquine, and artemisinin were administered to mice, and mRNA was collected following treatment for RT-PCR analysis of genes encoding deubiquitylating enzymes (DUBs). Curcumin was found be nontoxic in BALB/c mice. The combination of curcumin/chloroquine/piperine reduced parasitemia to 37% seven days after treatment versus the control group’s 65%, and an additive interaction was revealed. Curcumin/piperine/artemisinin combination did not show a favorable drug interaction in this murine model of malaria. Treatment of mice with subtherapeutic doses of the drugs resulted in a transient increase in genes encoding DUBs indicating UPS interference. If curcumin is to join the arsenal of available antimalarial drugs, future studies exploring suitable drug partners would be of interest.
APA, Harvard, Vancouver, ISO, and other styles
7

Khairani, Shafia, Nisa Fauziah, Hesti Lina Wiraswati, Ramdan Panigoro, Endang Yuni Setyowati, and Afiat Berbudi. "The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review." Journal of Tropical Medicine 2021 (October 11, 2021): 1–15. http://dx.doi.org/10.1155/2021/9135617.

Full text
Abstract:
Malaria remains a significant global health problem, but the development of effective antimalarial drugs is challenging due to the parasite’s complex life cycle and lack of knowledge about the critical specific stages. Medicinal plants have been investigated as adjuvant therapy for malaria, so this systematic review summarizes 46 primary articles published until December 2020 that discuss curcumin and piperine as antimalarial agents. The selected articles discussed their antioxidant, anti-inflammatory, and antiapoptosis properties, as well as their mechanism of action against Plasmodium species. Curcumin is a potent antioxidant, damages parasite DNA, and may promote an immune response against Plasmodium by increasing reactive oxygen species (ROS), while piperine is also a potent antioxidant that potentiates the effects of curcumin. Hence, combining these compounds is likely to have the same effect as chloroquine, that is, attenuate and restrict parasite development, thereby reducing parasitemia and increasing host survival. This systematic review presents new information regarding the development of a curcumin-piperine combination for future malaria therapy.
APA, Harvard, Vancouver, ISO, and other styles
8

Suresh, Kuthuru, M. K. Chaitanya Mannava, and Ashwini Nangia. "A novel curcumin–artemisinin coamorphous solid: physical properties and pharmacokinetic profile." RSC Adv. 4, no. 102 (2014): 58357–61. http://dx.doi.org/10.1039/c4ra11935e.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Thakkar, Vaishali Tejas, Rachana Dhankecha, Mukesh Gohel, Purvi Shah, Tosha Pandya, and Tejal Gandhi. "Enhancement of Solubility of Artemisinin and Curcumin by Co-Solvency Approach for Application in Parenteral Drug Delivery System." International Journal of Drug Delivery 8, no. 3 (2016): 77. http://dx.doi.org/10.5138/09750215.1868.

Full text
Abstract:
The aim of present study was to enhance solubility of poorly soluble antimalarial drugs, Artemisinin and Curcumin by adopting Co-solvency approach and to develop parenteral aqueous injectable solution. Solubility enhancement of both drugs was achieved using co-solvency approach. The parenteral injection was prepared by using a ternary co-solvent system which comprised of benzyl alcohol, PEG 400 and tween 80 (as surfactant). Solubility of Artemisinin and Curcumin was found to be higher in benzyl alcohol and PEG 400. Co-solvent system comprising of benzyl alcohol, PEG 400 and tween 80 in volume fraction of 0.3, 0.9 and 0.2 respectively showed the minimum required solubility of Artemisinin (90 mg per ml) and Curcumin (180 mg per ml). The parenteral injectable formulation was characterized for pH, clarity, viscosity, osmolarity and sterility and the stated parameters were found in acceptable range. <em>In-vitro </em>erythrocyte toxicity study showed that intravenous administration of optimized formulation will be safe. <em>In-vitro </em>antimalarial assay indicated that efficacy of artemisinin and curcumin parenteral formulation was greater than quinine and combination of Artemether and Lumefantrine. Stability study of the optimized batch showed no change in physical and chemical characteristics. Based on study, one can conclude that Artemisinin and Curcumin can be successfully formulated as parenteral injectable formulation by co-solvency approach for the effective treatment of malarial infection
APA, Harvard, Vancouver, ISO, and other styles
10

Urošević, Maja, Ljubiša Nikolić, Ivana Gajić, Vesna Nikolić, Ana Dinić, and Vojkan Miljković. "Curcumin: Biological Activities and Modern Pharmaceutical Forms." Antibiotics 11, no. 2 (2022): 135. http://dx.doi.org/10.3390/antibiotics11020135.

Full text
Abstract:
Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo through various mechanisms of action. Numerous studies have identified and characterised the pharmacokinetic, pharmacodynamic, and clinical properties of curcumin. Curcumin has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, and it is used as a wound-healing agent. However, poor curcumin absorption in the small intestine, fast metabolism, and fast systemic elimination cause poor bioavailability of curcumin in human beings. In order to overcome these problems, a number of curcumin formulations have been developed. The aim of this paper is to provide an overview of recent research in biological and pharmaceutical aspects of curcumin, methods of sample preparation for its isolation (Soxhlet extraction, ultrasound extraction, pressurised fluid extraction, microwave extraction, enzyme-assisted aided extraction), analytical methods (FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, UPLC/Q-TOF-MS) for identification and quantification of curcumin in different matrices, and different techniques for developing formulations. The optimal sample preparation and use of an appropriate analytical method will significantly improve the evaluation of formulations and the biological activity of curcumin.
APA, Harvard, Vancouver, ISO, and other styles
11

Yusuf, Amina S., Ibrahim Sada, Yusuf Hassan, Temitope O. Olomola, Christiana M. Adeyemi, and Sunday O. Ajibade. "Synthesis, Antimalarial Activity, and Docking Studies of Monocarbonyl Analogues of Curcumin." Ovidius University Annals of Chemistry 29, no. 2 (2018): 92–96. http://dx.doi.org/10.2478/auoc-2018-0013.

Full text
Abstract:
Abstract The synthesis of five monocarbonyl analogues of curcumin is described. In vitro anti-malarial assay of the compounds was carried out and the effect of the substituents on the aryl ring has been described. The results show that all the five compounds exhibited some reasonable activity against the chloroquine-resistant plasmodium parasite. Molecular docking studies further confirmed the observed biological activity of the compounds.
APA, Harvard, Vancouver, ISO, and other styles
12

Kamurai, Bridget, Molly Mombeshora, Stanley Mukanganyama, and Faham Khamesipour. "Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa." International Journal of Microbiology 2020 (September 29, 2020): 1–9. http://dx.doi.org/10.1155/2020/8885338.

Full text
Abstract:
Increasing cases of multidrug-resistant pathogens have evolved into a global health crisis. ESKAPE group of bacteria are associated with antibiotic resistance, and infections caused by these pathogens result in high mortality and morbidity. However, de novo synthesis of antibiotics is expensive and time-consuming since the development of a new drug has to go through several clinical trials. Repurposing of old drugs for the treatment of antimicrobial resistant pathogens has been explored as an alternative strategy in the field of antimicrobial drug discovery. Ten non-antimicrobial compounds were screened for antibacterial activity on two ESKAPE organisms, Staphylococcus aureus and Pseudomonas aeruginosa. The drugs used in this study were amodiaquine an antimalarial drug, probenecid used to prevent gout, ibuprofen a painkiller, 2-amino-5-chlorobenzaxazole used as a tool for assessing hepatic cytochrome P450 activity in rodents, ellargic acid an antioxidant, quercetin an antioxidant and anti-inflammatory drug, N–N diacryloylpiperazine used to crosslink polyacrylamide gel in 2D-protein electrophoresis, epicatechin an antioxidant and antiviral drug, curcumin an anticancer drug, and quinine an antimalarial drug. Antibacterial susceptibility tests were carried out for the 10 compounds. Curcumin exhibited the most potent antimicrobial activity against both bacteria, with MICs of 50 μg/ml and 100 μg/ml for P. aeruginosa and S. aureus, respectively. Ellargic acid was found to have an MIC of 100 μg/ml against S. aureus. Curcumin caused protein and nucleic acid leakage from the bacterial cell membrane in both bacterial species. When curcumin was combined with ciprofloxacin, it was found to enhance the antibacterial effects of ciprofloxacin. The combination with ciprofloxacin reduced the MIC for ciprofloxacin from 0.5 μg/ml to 0.0625 μg/ml on P. aeruginosa and 0.25 μg/ml to 0.0625 μg/ml on S. aureus. The results obtained show that curcumin has antibacterial activity against S. aureus and P. aeruginosa and may enhance the antibacterial activity of ciprofloxacin.
APA, Harvard, Vancouver, ISO, and other styles
13

Rashidzadeh, Hamid, Mahsa Salimi, Somayeh Sadighian, Kobra Rostamizadeh, and Ali Ramazani. "In vivo Antiplasmodial Activity of Curcumin-Loaded Nanostructured Lipid Carriers." Current Drug Delivery 16, no. 10 (2019): 923–30. http://dx.doi.org/10.2174/1567201816666191029121036.

Full text
Abstract:
Background: It was shown that curcumin (Cur) has anti-plasmodium activity, however, its weak bioavailability, rapid metabolism, and limited chemical stability has restricted its application in clinical usages. Nanostructured lipid carriers (NLCs) are a type of drug-delivery systems (DDSs) which their core matrix is composed of both solid and liquid lipids. Objective: The aim of the current study was to prepare and characterize curcumin-loaded nanostructured lipid carriers (Cur-NLC) for malaria treatment. Methods: For the production of NLC, coconut oil and cetyl palmitate were selected as a liquid and solid lipid, respectively. In order to prepare the Cur-NLC, the microemulsion method was applied. General toxicity assay on Artemia salina and also hemocompatibility was investigated. Antimalarial activity was studied on mice infected with Plasmodium berghei. Results: The NLCs mean particle size and polydispersity index (PI) was 145 nm and 0.3, respectively. Moreover, the zeta potential of the Cur-NLC was −25 mV, as well as, the NLCs showed pseudo-spherical shape which revealed via transmission electron microscopy (TEM). The loading capacity and encapsulation efficacy of the obtained Cur-NLC were 3.1 ± 0.015% and 74 ± 3.32%, respectively. In vitro, Cur release profiles showed a sustained-release pattern up to 5 days in synthesized Cur-NLC. The results of in vivo anti-plasmodial activity against P. berghei revealed that antimalarial activity of Cur-NLC was high 2-fold compared with bare Cur at the tested dosage level. Conclusion: : The results of this study showed that NLC would be used as a potential nanocarrier for the treatment of malaria.
APA, Harvard, Vancouver, ISO, and other styles
14

Alkandahri, Maulana Yusuf, Recky Patala, Afiat Berbudi, and Anas Subarnas. "Antimalarial activity of curcumin and kaempferol using structure-based drug design method." Journal Of Advanced Pharmacy Education And Research 11, no. 4 (2021): 86–90. http://dx.doi.org/10.51847/q7yye310jy.

Full text
APA, Harvard, Vancouver, ISO, and other styles
15

Martí Coma-Cros, Elisabet, Arnau Biosca, Elena Lantero, et al. "Antimalarial Activity of Orally Administered Curcumin Incorporated in Eudragit®-Containing Liposomes." International Journal of Molecular Sciences 19, no. 5 (2018): 1361. http://dx.doi.org/10.3390/ijms19051361.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Manohar, Sunny, Shabana I. Khan, Shamseer Kulangara Kandi, et al. "Synthesis, antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin." Bioorganic & Medicinal Chemistry Letters 23, no. 1 (2013): 112–16. http://dx.doi.org/10.1016/j.bmcl.2012.11.004.

Full text
APA, Harvard, Vancouver, ISO, and other styles
17

Balaji, S. N., Mohamed Jawed Ahsan, Surender Singh Jadav, and Vishal Trivedi. "Molecular modelling, synthesis, and antimalarial potentials of curcumin analogues containing heterocyclic ring." Arabian Journal of Chemistry 12, no. 8 (2019): 2492–500. http://dx.doi.org/10.1016/j.arabjc.2015.04.011.

Full text
APA, Harvard, Vancouver, ISO, and other styles
18

Kumar, Arun, Tapan Behl, Toshi Uniyal, and Swati Chadha. "Synthesis of Nanostructured Lipid Carriers Loaded Chitosan/ Carbopol Hybrid Nanocomposite Gel for Oral Delivery of Artemether and Curcumin." Pharmaceutical Nanotechnology 8, no. 5 (2020): 418–32. http://dx.doi.org/10.2174/2211738508666200907110444.

Full text
Abstract:
Background: Antimalarial therapy remains the utmost effective means for the management of malarial parasites in the liver and red blood cells. The application of these therapeutic agents is hampered by their improper application, hepato-toxicity caused by their continuous use, and degradation by hepatic enzymes. Methods: Recent advancements in drug delivery applications have shown potential in improving the pharmacological properties of artemether. Nanostructured lipid carriers (NLCs) loaded chitosan (CH)/Carbopol (CB) hybrid gel was prepared using glycerol monostearate (GMS) as solid lipid and clove oil as a liquid lipid for artemether (ART) and curcumin (CR) for its localized effect on the liver. Results: The smaller particle size (~118 ± 1.0 nm) and high zeta potential (- 41.1 ± 6.46 mV) confirm the formulation and stability of NLCs. On the other hand, the shape and morphology of prepared NLCs and gel showed a spherical and wrinkled surface with a size range of 150-250 nm. The release studies of the NLC’s showed a controlled release of artemether (~ 92%) and curcumin (~ 83%) for up to 30 h. Photostability data showed that, approximately, ~86.5 ± 0.3% and ~60 ± 0.9% of nanoencapsulated artemether and curcumin were still detected on exposure to sunlight, respectively. It has been found from the permeation study that 69.8% and 49.1% of the drug was permeated across the mucus membrane in 24 h with a significant increase (P < 0.05) in flux as well as permeability coefficients. Conclusion: The overall results showed that prepared CH/CB/NLCs hybrid gel could be a promising vehicle for the effective delivery of ART and CR for the management of malarial parasites. Lay Summary: Antimalarial therapy remains the utmost effective means for the management of malarial parasites in liver and red blood cells. Recent advancements in drug delivery applications have shown potential in improving the pharmacological properties of artemether. Application of these therapeutic agents hampered by their improper application, hepato-toxicity caused by their continuous use and degradation by hepatic enzymes. To manage the above issues, we synthesize nanostructured lipid carriers (NLC’s) loaded chitosan (CH)/Carbopol (CB) hybrid gel using glycerol monostearate (GMS) as solid lipid and clove oil as liquid lipid for artemether (ATR) and curcumin (CR) for its local action in liver and the major criteria were to find a protective barrier with hepatoprotective nature of the curcumin.
APA, Harvard, Vancouver, ISO, and other styles
19

AKERMI, SARRA, Neha Lohar, Subrata Sinha, Surabhi Johari, Sunil Jayant, and Anshul Nigam. "In-silico identification of natural antiviral drug against SARS-CoV-2 and comparison with potential FDA approved drug targets." Journal of Science 3, no. 4 (2020): 1–11. http://dx.doi.org/10.47944/jos.3.4.2020.1.

Full text
Abstract:
Antimalarial drugs Chloroquine and Hydroxychloroquine have garnered most attention recently as a successful remedy for COVID19. However, the use of these drugs is still questionable due to its undetermined efficacy and side effects. The present study utilizes in-silico high throughput screening of FDA approved antiviral compounds and secondary plant metabolites against spike protein of novel coronavirus (SARS-CoV-2). This target was chosen because it is instrumental in entry of virus into human cells. It is observed that the plant compound Tocopheryl-curcumin has more affinity for spike protein of SARS-CoV-2 in comparison to the majority of FDA approved drugs. Tocopheryl-curcumin binds with the binding site of RBD domain of spike protein (6VSB, chain A) with free energy (∆G) of binding of -11.20 kcal/mol and makes strong hydrogen bonds with amino acid residues of S366, V367, L368, S373, and K529. Among the FDA approved drugs, Pibrentasvir obtains top rank with free energy (∆G) of binding of -9.69 kcal/mol. whereas; surprisingly Chloroquine (-6.87 kcal/mol) and Hydroxychloroquine (-7.24 kcal/mol) ranked lower in our docking study. The toxicity prediction by VEGA predicts that tocopheryl-curcumin shows no toxicity as compared to FDA approved drugs. Therefore, we infer that the plant-based tocopheryl-curcumin could be considered as potential and safer drug against COVID 19 disease as compared to chemical based drugs.
APA, Harvard, Vancouver, ISO, and other styles
20

Santos, Renata Bem dos, Kelly Ayumi Nakama, Camila Oliveira Pacheco, et al. "Curcumin-loaded nanocapsules: Influence of surface characteristics on technological parameters and potential antimalarial activity." Materials Science and Engineering: C 118 (January 2021): 111356. http://dx.doi.org/10.1016/j.msec.2020.111356.

Full text
APA, Harvard, Vancouver, ISO, and other styles
21

Ji, Hong-Fang, and Liang Shen. "Interactions of curcumin with the PfATP6 model and the implications for its antimalarial mechanism." Bioorganic & Medicinal Chemistry Letters 19, no. 9 (2009): 2453–55. http://dx.doi.org/10.1016/j.bmcl.2009.03.060.

Full text
APA, Harvard, Vancouver, ISO, and other styles
22

Ali, Amatul Hamizah, Suhaini Sudi, Rusliza Basir, Noor Embi та Hasidah Mohd Sidek. "The Antimalarial Effect of Curcumin Is Mediated by the Inhibition of Glycogen Synthase Kinase-3β". Journal of Medicinal Food 20, № 2 (2017): 152–61. http://dx.doi.org/10.1089/jmf.2016.3813.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Isacchi, Benedetta, Maria Camilla Bergonzi, Margherita Grazioso, et al. "Artemisinin and artemisinin plus curcumin liposomal formulations: Enhanced antimalarial efficacy against Plasmodium berghei-infected mice." European Journal of Pharmaceutics and Biopharmaceutics 80, no. 3 (2012): 528–34. http://dx.doi.org/10.1016/j.ejpb.2011.11.015.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Kumar, Sahil, Kulvinder Singh, Rajesh K. Singh, DN Prasad, and TR Bhardwaj. "Recent advancesin the development of novel drug delivery systems for the prophylaxis of malaria." International Journal of Advances in Pharmaceutical Sciences 9, no. 3 (2018): 49. http://dx.doi.org/10.5138/09760155.2134.

Full text
Abstract:
<p>The present review high-lights the advancement in nanoparticles formulations for the prophylaxis of malaria. An attempt has been made to describe various novel drug delivery systems based on approaches such as polymeric, metallic, natural, chitosan/antisense (AS) and chitosan/sense (S) oligodeoxynucleotide based nanoparticles etc. for the treatment of malaria. The polymer such as chitosan, hydroxyl propyl methyl cellulose and polyvinyl pyrrolidone; the metal like gold and silver and other carriers such as glyceryl-dilaurate, albumin etc. have been explored for the development of novel nanoparticles formulations. These developed nanoparticles formulation have improved the targeted drug delivey of various clinically used antimalarial therapeutic agents such as hydroxychloroquine, curcumin, artemisinin, artemether and lumefantrine etc.</p>
APA, Harvard, Vancouver, ISO, and other styles
25

Graham, Michael, Yonghong Yang, Aled D Roberts, and Haifei Zhang. "Poorly Water Soluble Drug Nanostructures via Surface Solvent Evaporation." Nano LIFE 05, no. 03 (2015): 1540005. http://dx.doi.org/10.1142/s179398441540005x.

Full text
Abstract:
A high percentage of developed drug compounds are poorly soluble in water, which severely limits their applications. Nanotechnology has been used to address this issue. Here we describe a simple and versatile bottom-up approach for the preparation of drug nanostructures by surface solvent evaporation on aluminum surface and polymer-coated surface. Three poorly water soluble drug compounds, including griseofulvin (GF), curcumin and antimalarial compound SL-2-25 have been investigated as model compounds. The structures are mainly characterized by scanning electronic microscopy (SEM) while the GF nanoparticles are also examined by powder X-ray diffraction (PXRD) and thermogravimetric analysis (TGA). A variety of structures including microassemblies composed of nanoparticles, nanospheres and nanofibers have been produced. A sonication method can be employed to produce aqueous nanoparticle suspension.
APA, Harvard, Vancouver, ISO, and other styles
26

Gogoi, Kabita, Dipak Chetia, Nabin Chandra Barua, Neelutpal Gogoi, and Chandrajit Dohutia. "In vitro antimalarial evaluation and molecular docking analysis of Mannich base curcumin analogues against the artemisinin target PfATP6." Asian Journal of Pharmacy and Pharmacology 5, no. 1 (2018): 120–28. http://dx.doi.org/10.31024/ajpp.2019.5.1.17.

Full text
APA, Harvard, Vancouver, ISO, and other styles
27

Jain, Shweta, Ankur Vaidya, Pawan Kumar Gupta, Jessica M. Rosenholm, and Kuldeep K. Bansal. "Antiarthritic Activities of Herbal Isolates: A Comprehensive Review." Coatings 11, no. 11 (2021): 1329. http://dx.doi.org/10.3390/coatings11111329.

Full text
Abstract:
Numerous plant isolates with therapeutic properties, such as antimicrobial, antiinflammatory, antiviral, antimalarial, antiarthritic (AA), hepatoprotective, cardiotonic, and so forth, are reported in the literature. Usually, medicinal plants are widely used, and assumed to be safe and cheaper alternatives to chemically synthesized drugs. However, they are not regulated for potency and purity, and thus care must be taken for their safe use. In this review, we aimed to compile all of the herbal isolates possessing AA properties, including alkaloids (montanine, 3-acetylaconitine, sanguinarine, jatrorrhizine hydrochloride, and piperine), terpenoids (eugenol, nimbolide, bartogenic acid, cannabidiol, and curcumin), and flavonoids (quercetin, resveratrol, kaempferol, chebulanin, ellagic acid, rosmarinic acid, gallic acid, chlorogenic acid, ferulic acid, and brazilin). These isolates act through numerous pharmacological mechanisms such as inhibiting cytokines, chemokines, or matrix metalloproteinase, etc., to demonstrate AA activity. Animal models utilized for assessing the AA properties of these isolates, including adjuvant-induced arthritis mouse models, are also discussed. Furthermore, nanotechnology-based approaches to deliver these isolates are also reviewed, which have shown improved therapeutic efficacy of isolated compounds.
APA, Harvard, Vancouver, ISO, and other styles
28

A. Fadare, Olatomide, Ezekiel O.Iwalewa, Craig A. Obafemi, and Feyisola P. Olatunji. "In-silico Antimalarial Study of Monocarbonyl Curcumin Analogs and Their 2,4-Dinitro Phenylhydrazones Using the Inhibition of Plasmepsin II as Test Model." American Journal of Pharmacological Sciences 5, no. 2 (2017): 18–24. http://dx.doi.org/10.12691/ajps-5-2-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
29

Fitriastuti, Dhina, Tatang Shabur Julianto, and Annisa Wahyu Nur Iman. "Identification and Heme Polymerization Inhibition Activity (HPIA) Assay of Ethanolic Extract and Fraction of Temu Mangga (Curcuma mangga Val.) Rhizome." EKSAKTA: Jurnal Ilmu-ilmu MIPA 20, no. 1 (2020): 64–72. http://dx.doi.org/10.20885/eksakta.vol1.iss1.art10.

Full text
Abstract:
Curcuma mangga Val. is one of Indonesian herbs from Zingiberaceae family that is under explored and could contain potentially active substances to serve as an antimalarial. This research intends not only to examine the antimalarial activity by means of heme polymerization inhibitor mechanism by using the ethanolic extract and fraction of Curcuma mangga Val. but also to identify its compound classification. The extract of temu manga was obtained by Soxhlet extraction method using ethanol solvent followed by fractionation using Vacuum Liquid Chromatography with solvent sequence n-hexane, n-hexane: ethyl acetate (2:1), ethyl acetate and ethanol. The extract and fraction were analyzed by using LC-MS and GC-MS. Activities of hem polymerization inhibition showed by IC50 values which were obtained from analysis of relationship between concentration sample and the percentage of inhibition using the PROBIT on statistical software. The result of HPIA assay shows that the IC50 value of ethanolic extract and ethanolic fraction of Curcuma mangga Val. rhizome are 2.273 and 1.479 mg/mL, respectively. It clearly shows that the heme polymerization inhibition activity of ethanolic fraction relatively better than that of ethanolic extract. Phytochemical screening determines the ethanolic extract contains saponin, terpenoid, and phenol while the ethanolic fraction contains terpenoid. Thus, terpenoid compound is presumed to be the inhibitor of heme polymerization. The results of analysis with LC-MS and GC-MS showed that the active compounds suspected to inhibit heme polymerization in ethanolic extract and fraction were (E) -labda-8 (17), 12-dien-15,16-dial and di-n-octyl phthalate, respectively. Keywords: antimalarial, Curcuma mangga Val., heme polymerization
APA, Harvard, Vancouver, ISO, and other styles
30

ONYEJI, Cyprian O. "PROSPECTS OF INTEGRATION OF NANOTECHNOLOGY TO ANTIMALARIAL HERBAL REMEDIES FOR IMPROVED THERAPEUTIC EFFICACY – A CONCISE REVIEW." African Journal of Traditional, Complementary and Alternative Medicines 18, no. 1 (2022): 27–35. http://dx.doi.org/10.21010/ajtcamv18i1.3.

Full text
Abstract:
Background: The therapeutic utility of herbal medicinal products including antimalarial herbal remedies has been hampered by some unfavorable biopharmaceutical properties of the bioactive constituents such as low aqueous solubility, poor oral bioavailability, poor intestinal permeability and large molecular size. Al these biopharmaceutical issues are responsible for observed reduced in vivo efficacy of some herbal products compared to their in vitro efficacy. These drawbacks can by countered by the integration of nanotechnology. The present article identified the various documented nanosystems and examined the recent efforts in the deployment of nanotechnology in formulations of antimalarial herbal medicines for improved therapeutic efficacies. Also safety considerations in clinical applications of nanoformulations were highlighted. Methods: The information was acquired from an extensive literature searching of electronic databases such as Science-Direct, PubMed, and Google-Scholar to obtain appropriate articles made in the English language which were published up to 2022, using a combination of relevant keywords. Results: Only very few herbal antimalarial remedies such as extracts of Azadirachta indica, Momordica charantia, Curcuma longa, and Artemisia species have been nanoformulated and evaluated for antimalarial efficacy. In all these studies, the drug-loaded nanoformulations exhibited significantly higher in vitro and/or in vivo antimalarial efficacy. The different nanoformulations of antimalarial herbal remedies that have been reported include nanoparticles of lipid-based, cyclodextrin, chitosan/lecithin , liposomes, nanosuspension, nanoemulsions, and metal-based nanoparticles.. Conclusion: Different types of nanoformulations of herbal antimalarial drugs have been reportedly prepared by different techniques and these offer advantages of improved efficacies. Safety concerns present a hurdle to clinical applications
APA, Harvard, Vancouver, ISO, and other styles
31

Tjahjani, S., Syafruddin, and R. Tjokropranoto. "Interaction of alphamangostin and curcumin with dihydroartemisinin as antimalaria in vitro." IOP Conference Series: Earth and Environmental Science 125 (March 2018): 012017. http://dx.doi.org/10.1088/1755-1315/125/1/012017.

Full text
APA, Harvard, Vancouver, ISO, and other styles
32

Oladeji, Oluwole Solomon, Abimbola Peter Oluyori, Deborah Temitope Bankole, and Tokunbo Yemisi Afolabi. "Natural Products as Sources of Antimalarial Drugs: Ethnobotanical and Ethnopharmacological Studies." Scientifica 2020 (May 11, 2020): 1–22. http://dx.doi.org/10.1155/2020/7076139.

Full text
Abstract:
Ethnopharmacological Relevance. Malaria is one of the lethal diseases of man, contributing to about 17 million deaths annually, leading to sociocultural, economic, and health influences. Aim of the Study. The study explores the ethnobotanical and ethnopharmacological appraisal of antimalarial plants used by people of Omu Aran, Ogbomoso, Ado Ekiti, and Sagamu communities in Nigeria. Materials and Methods. For this study, relevant information was procured from the inhabitants via a structured questionnaire to procure the general knowledge of antimalarial medicinal plants. Results and Discussion. A total of 90 interviewees (44 men and 46 women) were involved in this survey. A total of 59 medicinal species were identified, which were dispersed in 33 families (Asteraceae (6), Apocynaceae (5), Anacardiaceae, Annonaceae, Fabaceae, Malvaceae, Meliaceae, Poaceae, and Rubiaceae (3 each), Phyllanthaceae (2)) totaling 49% of the cited species. The most cited plants are Azadirachta indica (42), Mangifera indica (38), Carica papaya (28), Cymbopogon citratus (27), Cassia fistula (15), Morinda lucida (14), Anacardium occidentale and Vernonia amygdalina (13 each), Helianthus annuus (11), Enantia chlorantha (10), and Moringa oleifera (9) A total of 105 citations were recorded for the plant parts used (leaf (46), bark (17), fruits (9), root (9), latex (11), stem (11), and inflorescence (2)) while decoction (59%), maceration (25%), infusion (9%), and exudation (7%) were the methods of preparation. Use Values (UVs) of 0.47 to 0.11 were recorded for the frequently used antimalarial plants. The Efficiency Levels (ELs) of 11 different medicinal plants stated by the respondents were Azadirachta indica, Cassia fistula and Morinda lucida (12), Chromolaena odorata (10), Mangifera indica, Enantia chlorantha and Helianthus annuus (8), Cymbopogon citratus (7), Gossypium arboretum (4), Landolphia dulcis (3), and Aloe vera (2) Cocos nucifera, Curcuma longa, Forkia biglobosa, and Musa acuminate are mentioned for the first time in the study area with little or no reported antiplasmodial activities. Conclusion. The study appraised the commonly used antimalarial plants in the study areas. Therefore, commitment to scientifically explore the bioactive compounds, antimalarial potential and toxicological profile of these plants is inevitable as they could lead to novel natural products for effective malaria therapy.
APA, Harvard, Vancouver, ISO, and other styles
33

Lwin, Khin Myat, Hla Myat Mon, and Khin Htay Myint. "Evaluation of the antimalarial activity of Curcuma longa Linn., singly and in combination with Eupatorium odoratum Linn." Journal of Ayurvedic and Herbal Medicine 3, no. 1 (2017): 11–14. http://dx.doi.org/10.31254/jahm.2017.3103.

Full text
Abstract:
Following the observation of in vitro anti-malarial activity of the ethanolic extract of Curcuma longa Linn., the active compound was isolated from its rhizome and detected in vitro, the results showed that schizont suppression of 62.63% even at the lowest concentration 0.625 µg/ml on human malaria with IC50 values of <0.625ug/ml. Another test sample extract of Eupatorium odoratum Linn, revealed that the significant antimalarial activity with IC50 value of 0.8581 ug/ml. The combination of C. longa and E. odoratum was found to be IC50 of <0.625 µg/ml showing their probable synergistic effect on the human malaria parasite. The extract and isolated compound of C. longa was further tested for their antimalarial activity using Plasmodium berghei mouse model. The highest in vivo parasite suppression was found to be 67.9% and 72.97% at the dosage of 50 mg/kg body weight for C. longa extract and isolated compound respectively. Moreover, brine shrimp toxicity test and in vivo toxicity test in mice showed no lethal effect of both C. longa and E. odoratum at the tested concentration which is moderately high. The results showed that both plant samples are potentially safe and possess prospective anti-malarial activity. It can be used as a single or combination.
APA, Harvard, Vancouver, ISO, and other styles
34

Omagha, R., E. T. Idowu, C. G. Alimba, A. O. Otubanjo, E. O. Agbaje, and H. C. N. Ajaegbu. "Physicochemical and phytochemical screening of six plants commonly used in the treatment of malaria in Nigeria." Journal of Phytomedicine and Therapeutics 19, no. 2 (2021): 483–501. http://dx.doi.org/10.4314/jopat.v19i2.6.

Full text
Abstract:
Medicinal plants contain active compounds usually present as complex mixtures though at low concentrations, which accounts for the medicinal properties. Therefore it is important to identify and characterize these compounds. This study aims to quantify and characterize the physicochemical and phytochemical compositions of six plants commonly used in the treatment of malaria using High-Performance Liquid Chromatography (HPLC). These plants which are used individually or in combinations: Enantia chlorantha, Cymbopogon citratus, Curcuma longa, Carica papaya, Alstonia boonei and Mangifera indica, were extracted with hot water and the extracts characterized with HPLC using standard procedures. The results showed that M. indica stem bark had the highest yield with 81.48% and C. papaya had the lowest yield with 53.80%. Physicochemical properties of the extracts of E. chlorantha, C. citratus, C. longa, C. papaya, A. boonei and M. indica respectively are as follows: Melting point 90, 80, 95, 92, 96 and 96; pH 7.43, 8.02, 6.24, 6.81, 6.41, 6.85; moisture content 18.27, 22.77, 9.96, 9.62, 3.85 and 10.00; Total ash 1.45, 3.51, 0.34, 0.57, 9.10,10.21; refractive index 1.34, 1.34, 1.34, 1.34, 1.34, 1.34 and 1.34. Alkaloids, phenols, flavonoids, terpenoids, tannins, coumarin were some of the antimalarial active phytochemicals identified. Alkaloid (Atropine) was highest in C. longa (4382.2mg/g). M. indica (32982.8mg/g) had the highest Rutin Hydrate content. While Quercetin was not detected in C. papaya, it was considerably present in A. boonei (491.1mg/g). All the analyzed six plants contain low phenol (gallic acid). The characterized physicochemical and phytochemical compositions of the examined plants suggests why the plants are effective in the treatment of malaria. The information reported herein describes the physicochemical and phytochemical contents of six commonly used antimalarial plants in Nigeria. It is expected that the information will be useful in understanding the pharmaceutical effects of how the plants work in the body and in the development of efficacious and safe antimalarial drugs.
APA, Harvard, Vancouver, ISO, and other styles
35

Annadurai, Ramasamy S., Ramprasad Neethiraj, Vasanthan Jayakumar, et al. "De Novo Transcriptome Assembly (NGS) of Curcuma longa L. Rhizome Reveals Novel Transcripts Related to Anticancer and Antimalarial Terpenoids." PLoS ONE 8, no. 2 (2013): e56217. http://dx.doi.org/10.1371/journal.pone.0056217.

Full text
APA, Harvard, Vancouver, ISO, and other styles
36

Martinez-Correa, Hugo A., Julia T. Paula, Ana Carolina A. V. Kayano, et al. "Composition and antimalarial activity of extracts of Curcuma longa L. obtained by a combination of extraction processes using supercritical CO2, ethanol and water as solvents." Journal of Supercritical Fluids 119 (January 2017): 122–29. http://dx.doi.org/10.1016/j.supflu.2016.08.017.

Full text
APA, Harvard, Vancouver, ISO, and other styles
37

PÉREZ, Diana. "ETNOBOTÁNICA MEDICINAL Y BIOCIDAS PARA MALARIA EN LA REGIÓN UCAYALI." Folia Amazónica 13, no. 1-2 (2006): 87. http://dx.doi.org/10.24841/fa.v13i1-2.136.

Full text
Abstract:
El acopio y sistematización etnobotánica de la variedad de especies con potencial antimalárico y biocida para el control del vector de la malaria, fue realizada entre febrero y diciembre del 2000. Las localidades evaluadas se ubican en la selva baja de la Amazonía peruana, comprensión de los distritos de Callería, Yarinacocha y Campo Verde, de la provincia Coronel Portillo y el distrito de Irazola, en la provincia de Padre Abad, de la región Ucayali (07°57’25" y 9°27’10" latitud sur, 74°10’50" y 75°56’40" longitud oeste), donde ocurren mayores casos de malaria por Plasmodium vivax, y aisladamente por P. falciparum. Este documento constituye la primera fase de un estudio amplio sobre el control de la malaria, en la búsqueda de nuevos compuestos químicos como alternativas para promover el cultivo de especies útiles de la flora nativa. El contenido es el resultado de la encuesta a 367 personas, quienes mencionaron 55 especies. De estas, Verbena litoralis (Verbenaceae), Aspidosperma excelsum (Apocynaceae), Curcuma longa (Zingiberaceae), Cedrela odorata (Meliaceae), Abuta grandifolia (Menispermaceae) y Physalis angulata (Solanaceae) son usadas con mayor frecuencia para el control de la malaria, y Mansoa alliacea(Bignoniaceae), Petiveria alliacea y Gallesia integrifolia (Phytolacaceae), Capsicum annuum (Solanaceae) y Chenopodium ambrosioides (Chenopodiaceae), Bixa orellana (Bixaceae), Copaifera paupera (Fabaceae), Jacaranda copaia (Bignoniaceae), Zebrina pendula (Commelinaceae), Ambrosia artemisioides (Asteraceae) y Heliotropium indicum (Boraginaceae), para controlar los vectores de la malaria.La selección de las especies con propiedades antimalarica y controladoras de losvectores, es el resultado de siglos de experimentación por las poblaciones locales indígenas y mestizas. Los trabajos de campo llevados a cabo hasta esta fase, han motivado un particular interés en la población local, ante las expectativas de la valoración científica de sus conocimientos, que representan un paliativo de sus dificultades económicas, sin efectos residuales en la salud humana.
APA, Harvard, Vancouver, ISO, and other styles
38

"Investigation on Antimalarial Activity of Rhizome of Zingiber cassumunar Roxb. (Meik-tha-lin-oot)." Myanmar Health Sciences Research Journal 31, no. 3 (2019): 257–62. http://dx.doi.org/10.34299/mhsrj.00957.

Full text
Abstract:
This research aims to investigate the antimalarial activity of rhizome of Zingiber cassumunar Roxb. (Meik-tha-lin-oot). The preliminary phytochemical investigation revealed the presence of a-amino acids, carbohydrates, glycosides, organic acids, phenolic compounds, reducing sugars, saponins, starch and terpenoids. The various crude extracts such as PE (7.11%), 95% EtOH (3.44%), EtOAc (1.64%) and H2O (1.44%) extracts were prepared by successive solvent extraction method. Curcumin (orange amorphous crystal, 0.00317% yield, M.pt=183ºC) was isolated from EtOAc crude extract by using thin layer and column hromatographic separation techniques and identified by comparing with UV and FTIR spectral data of the standard curcumin. In vitro antimalarial activities of curcumin, ethanol and watery extracts were screened by using the reported method. The ethanol and watery extracts had no antimalarial activity (EC50 values=398.07 µg/ml and 501.00 µg/ml) whereas the isolated compound, curcumin was found to inhibit the growth of Plasmodium falciparum (EC50=101.74 µg/ml). On the other hand, the isolated compound, curcumin exhibited the moderate antimalarial activity and may be used as a potential compound to be tested for newer antimalarial agent.
APA, Harvard, Vancouver, ISO, and other styles
39

Srivastava, Richa, Zeeshan Fatima, Jagannath Sahoo, Prince Joshi, and Renu Tripathi. "Dihydroartemesinin and Curcumin Based Self-Microemulsifying Drug Delivery System for Antimalarial Activity." Drug Research, August 11, 2022. http://dx.doi.org/10.1055/a-1879-2758.

Full text
Abstract:
AbstractMalaria is a significant global problem which still persists despite the development of various effective antimalarial drugs. It is challenging to treat this disease due to the parasite’s complex life cycle and high recrudensce of antimalarial drugs. A new self-micro emulsifying drug delivery system has been developed to improve the solubility of dihydroartemisinin and curcumin. The prepared formulation contained Dihydroartemesinin, curcumin, Groundnut Oil, Cremephor RH, and Tween 80. Self-micro emulsification time, zeta potential, droplet size, polydispersity index, transmission electron microscopy, drug release, and in-vivo studies were performed for characterization. The globule size was found to be 25.59±0.40 nm and the zeta potential was-5.75±0.18 mV. The globules prepared were spherical in shape. The in-vitro dissolution performance of formulation of dihydroartemisinin and curcumin self emulsifying drug delivery system showed significantly (p<0.05, Origin Pro 8.5) higher release as compared to the pure drugs. The results of the study suggested that the prepared self emulsifying drug delivery system combination of Dihydroartemesinin and curcumin has a better potential to cure parasitemia as compared to the individual drug.
APA, Harvard, Vancouver, ISO, and other styles
40

Gomes, Patrícia Ramos, Fábio Balbino Miguel, Michael Éder de Oliveira, et al. "Synthesis and evaluation of antimalarial activity of curcumin derivatives." Química Nova 37, no. 3 (2014). http://dx.doi.org/10.5935/0100-4042.20140075.

Full text
APA, Harvard, Vancouver, ISO, and other styles
41

Ghosh, Aparajita, Tanushree Banerjee, Avadhesha Surolia, and Suman Bhandary. "Formulation of nanotized curcumin and demonstration of its antimalarial efficacy." International Journal of Nanomedicine, November 2014, 5373. http://dx.doi.org/10.2147/ijn.s62756.

Full text
APA, Harvard, Vancouver, ISO, and other styles
42

Dohutia, Chandrajit, Dipak Chetia, Kabita Gogoi, Dibya Ranjan Bhattacharyya, and Kishore Sarma. "Molecular docking, synthesis and in vitro antimalarial evaluation of certain novel curcumin analogues." Brazilian Journal of Pharmaceutical Sciences 53, no. 4 (2018). http://dx.doi.org/10.1590/s2175-97902017000400084.

Full text
APA, Harvard, Vancouver, ISO, and other styles
43

Septiana, Eris, Fauzy Rachman, Sylvia J. R. Lekatompessy, Harmastini I. Sukiman, and Partomuan Simanjuntak. "ISOLASI DAN IDENTIFIKASI KAPANG ENDOFIT ASAL AKAR TANAMAN KUNYIT (Curcuma longa) SEBAGAI ANTIMALARIA." BERITA BIOLOGI 17, no. 3 (2018). http://dx.doi.org/10.14203/beritabiologi.v17i3.3408.

Full text
Abstract:
Malaria is still the leading cause of death worldwide with nearly half the world's population at risk. Parasitic resistance to existing antimalarial drugs in the market makes the search for a source of new drugs from nature is very important. Therefore, the aims of this study are to determine in vitro antimalarial activity of endophytic fungi extract from turmeric root and to identify the selected isolate molecularly. Heme polymerization inhibition method was used as in vitro antimalarial assay. The selected isolate was thrn identified using ITS1, ITS2, and 5.8S sequences of rDNA. The result of this study obtained 16 isolates of endophytic fungi from root of turmeric plant with isolate code were of K.Cl.Sb.A1 - K.Cl.Sb.A16. All of the ethyl acetate extracts of isolated endophytic fungi have heme polymerization inhibition activity. K.Cl.Sb.A11 was the most active isolate on heme polymerization inhibition test with 94,31% at concentration of test material at 8 mg/mL and IC50 value at 1.84 mg/mL. Molecular analysis showed that K.Cl.Sb.A11 isolate was Penicillium sp. and potentially developed as an antimalarial drug.
APA, Harvard, Vancouver, ISO, and other styles
44

Subedi, Thaneshwar. "A Study on the Medicinal Chemistry of Curcuma Longa." Himalayan Biodiversity, December 12, 2019, 39–46. http://dx.doi.org/10.3126/hebids.v7i1.40188.

Full text
Abstract:
Plants are the major source of drug in the modern as well as traditional system of medicine throughout the world. Curcuma longa belonging to the family Zingiberaceae, is a medicinally important perennial herb distributed throughout the tropical and subtropical regions of the world from sea level to 1200 m. Therapeutically, C. longa has been used for curing various diseases such as asthma, anemia, chronic bronchitis, fever, dysentery, cough, diabetes, diarrhea, eye disease, hepatitis, hysteria, indigestion, itching, leprosy, liver disorder, menstrual disorder, peptic ulcer, small pox, chicken pox, tonsillitis, urinary infection etc. The objective of the study was phytochemical screening of C. longa for highlighting the traditional uses and pharmacological properties of its rhizomes. The rhizomes were collected from Pokhara Metropolitan -3, Nadipur, Nepal in November 2019. The collected rhizomes were washed thoroughly, cut into pieces, shaded dried completely, grinded into fine powder, extracted by Soxhlet extractor, evaporated the extract to get dark orange residue. Phytochemical screening was conducted by using standard methods. Phytochemical analysis of methanolic and ethanolic rhizome extract of C. longa showed that it contained alkaloids, steroids, tannins, flavonoids, carbohydrates, cardiaic, glycosides, phytosterol, anthocyanin, emodins, diterpenes, leuco anthocyanin, anthroquinone, chalcones, phenols, coumarin and phlobatannin in methanolic extract but not in ethanolic. Previous pharmacological studies on C. longa showed that it possessed antiviral, antifungal, anticancer, antidepresent, antimalarial, antimicrobial, antioxidant, antiplatelet, antibacterial, antivenum, antimutagenic and anticarcenogenic activities. Further phytochemical analysis using solvents of different polarity is necessary to identify much more phytochemical constituents for highlighting pharmacological and traditional medicinal properties.
APA, Harvard, Vancouver, ISO, and other styles
45

Roger, Tsobou, Hamawa Yougouda, Fawa Guidawa, et al. "Can antimalarial, antiviral and anti-respiratory infections Cameroonian medicinal plants be used as one of the potential ways to cure COVID-19? Pharmacological and ethnomedicinal proof." Journal of Medicinal Herbs and Ethnomedicine, July 20, 2020, 61–85. http://dx.doi.org/10.25081/jmhe.2020.v6.6240.

Full text
Abstract:
COVID-19 is a severe acute respiratory syndrome-related corona-virus SARS-CoV-2, that constitutes a pandemic threat to global public health. Unfortunately, there are no specific available therapies. This research work presents the findings of an investigation on traditional Cameroonian remedies of respiratory tract infections, malaria and viral infections, and also recipes that could serve as a baseline for the prevention, alleviate symptoms, treatment and perhaps may help for the anti-COVID-19 drugs discovery. Data on the medicinal plants were collected from traditional healers, Cameroonian medicinal plants books, the internet, and in addition to our personal experience as researchers and herbalists. Details of 85 plant species used to manage these three mentioned diseases in Cameroon and their pharmacological properties are recorded. Due to their ethnomedicinal uses and pharmacological activities, twenty-eight (28) plant species and 13 recipes are suggested for COVID-19 prevention, alleviate symptoms, treatment and baseline for anti-COVID-19 drug discovery. Amongst the proposed plants we have the following, Curcuma longa, Azadirachta indica, Zingiber officinale, Allium sativum and Ocimum gratissimum which were reported to possess certain inhibition properties against COVID-19 protease.
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography