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Journal articles on the topic 'Curcumin Phytosomes'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Pawar, Harshal A., and Bhagyashree D. Bhangale. "Development and Evaluation of Sustained Release Lipid Nanocarriers for Curcumin." Current Nanomaterials 5, no. 3 (2020): 224–35. http://dx.doi.org/10.2174/2405461505999200917122147.

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Background: Lipid based excipients have increased acceptance nowadays in the development of novel drug delivery systems in order to improve their pharmacokinetic profiles. Drugs encapsulated in lipids have enhanced stability due to the protection they experience in the lipid core of these nano-formulations. Phytosomes are newly discovered drug delivery systems and novel botanical formulation to produce lipophilic molecular complex which imparts stability, increases absorption and bioavailability of phytoconstituent. Curcumin, obtained from turmeric (Curcuma longa), has a wide range of biologic
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2

Nikhil, Khopade* Kakasaheb kore Sucheta bhise Adinath bhusari Dr. Rajkumar Shete. "Curcumin Phytosomes: A Promising Nanocarrier System for Enhancing Bioavailability and Therapeutic Efficacy." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2448–60. https://doi.org/10.5281/zenodo.15425503.

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Curcumin: a polyphenolic compound extracted from turmeric with widespread therapeutic potential, particularly its anti-inflammatory, antioxidant, anticancer, and antimicrobial properties. But its clinical usage is limited by low aqueous solubility, low absorption, rapid metabolism, and fast systemic clearance, leading to poor bioavailability. To overcome these limitations, nanocarrier systems such as phytosomes a special phospholipid complex system have been introduced for effective drug delivery. Curcumin phytosomes are a styudied formulation consisting of a mixture of curcumin
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Mavi, Nitin, Pankaj Kumar Sharma, and Dilip Kumar Gupta. "Phytosomes: Bridging Nature And Nanotechnology For Enhanced Drug Delivery." International Journal of Environmental Sciences 11, no. 8s (2025): 801–18. https://doi.org/10.64252/qj5e5a23.

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The development of phytosomal drug delivery systems represents a significant advancement in natural medicine, addressing longstanding challenges associated with botanical compounds, including poor absorption and permeation rates, as well as limited bioavailability. The molecular interaction between phytoconstituents and phospholipids, particularly phosphatidylcholine, results in the formation of phytosomes, which substantially improve the lipophilicity and absorption characteristics of hydrophilic extracts. This phytosomal system provides two primary advantages through its pharmaco-absorptive
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Allam, Ahmed N., Ibrahim A. Komeil, and Ossama Y. Abdallah. "Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization." Acta Pharmaceutica 65, no. 3 (2015): 285–97. http://dx.doi.org/10.1515/acph-2015-0029.

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Abstract Curcumin, a naturally occurring lipophilic molecule can exert multiple and diverse bioactivities. However, its limited aqueous solubility and extensive presystemic metabolism restrict its bioavailability. Curcumin phytosomes were prepared by a simple solvent evaporation method where free flowing powder was obtained in addition to a newly developed semisolid formulation to increase curcumin content in softgels. Phytosomal powder was characterized in terms of drug content and zeta potential. Thirteen different softgel formulations were developed using oils such as Miglyol 812, castor oi
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Kumar, M. Surendra, K. Dhivya, D. Lokesh, et al. "Phytosomes: nature’s secret to enhanced bioavailability." Journal of Applied Pharmaceutical Research 12, no. 6 (2024): 88–99. https://doi.org/10.69857/joapr.v12i6.702.

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Background: Medicinal herbs have long been used for treating various ailments, with plant-derived compounds recognized for their therapeutic benefits and minimal side effects compared to conventional medicines. However, issues with the bioavailability of active herbal components have limited their effectiveness. Phytosomes, or herbosomes, are a drug delivery technology that enhances the absorption and bioavailability of these plant-based compounds, providing a potential solution for maximizing the medicinal efficacy of herbal ingredients. Method: Phytosome complexes are synthesized by combinin
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Pratiksha, Hajare Mahesh Reddy Vedashree Dhumekar Yogesh Somwanshi. "Enhancing Cancer Therapy with Phytosomes: A Review of Mechanisms." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 1889–99. https://doi.org/10.5281/zenodo.14450759.

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Phytosomes, advanced delivery systems that enhance the bioavailability and efficacy of plant-derived compounds, have gained significant attention in cancer therapy. This review explores the mechanisms through which phytosomes enhance anticancer activity, including improved drug solubility, enhanced cellular uptake, and sustained drug release. We discuss their ability to overcome challenges in conventional therapies, such as poor bioavailability, systemic toxicity, and drug resistance, by encapsulating bioactive phytochemicals like curcumin, quercetin, and resveratrol. Moreover, we examine thei
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Saeed, Muhammad, Soheil Sadr, Arian Gharib, et al. "Phytosomes: A Promising Nanocarrier for Enhanced Delivery of Herbal Compounds in Cancer Therapy." Journal of Lab Animal Research 1, no. 1 (2022): 26–32. http://dx.doi.org/10.58803/jlar.v1i1.8.

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Cancer is a life-threatening disease that remains a global health problem, with millions of people diagnosed yearly. Despite significant progress in cancer treatment, conventional chemotherapy still faces several limitations, including poor solubility, low bioavailability, lack of selectivity, and severe side effects. Therefore, alternative therapeutic strategies are necessary to improve cancer therapy. This review aimed to provide an updated overview of phytosome complexes and their potential application in cancer therapy, including their formulation techniques, transportation mechanism throu
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Sneha, Karkute Kunti Shinde Pooja Rasal*. "Application Of Phytosome In Wound Healing: A Comprehensive Review." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 600–611. https://doi.org/10.5281/zenodo.14151452.

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Wound healing is a crucial physiological process involving complex cellular and molecular mechanisms. Conventional treatments often struggle with limited drug bioavailability, stability, and side effects. Phytosome technology offers an innovative solution to enhance the efficacy of phytoconstituents in wound healing. This review explores the application of phytosomes in wound care, focusing on their mechanisms of action, specific phytoconstituents used, clinical evidence, and future directions. Phytosome-based formulations, such as those containing curcumin, quercetin, and resveratrol, have de
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Ibrahim, Angum MM, Siham K. AbdelRahim, Huriyyah A. Alturaifi, and Intisar AM Elalawy. "Development and Evaluation of Herbal Antiacne Gel Formulation Using Curcumin Phytosomes ." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1435–40. http://dx.doi.org/10.25258/ijddt.14.3.26.

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Acne vulgaris is a persistent inflammatory condition affecting the pilosebaceous unit that manifests as various skin lesions, including papules, comedones, cysts, pustules, and abscesses. Curcumin, extracted from Curcuma longa rhizomes (Family: Zingiberaceae), is identified for its potent antioxidant, wound-healing, and anti-inflammatory properties. This study aimed to develop an herbal antiacne gel formulation incorporating bioactive curcumin in phytosomes. The formulated gel was evaluated for several physicochemical properties, including pH, spreadability, viscosity, drug content, etc. Addit
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Shrayner, E. V., K. M. Nikolaychuk, M. V. Khvostov, et al. "Pharmacokinetics, side effects, dosage forms, drug interactions of curcu-mine." Experimental and Clinical Gastroenterology, no. 9 (March 6, 2025): 147–60. https://doi.org/10.31146/1682-8658-ecg-229-9-147-160.

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This review presents current data on the pharmacokinetics, side effects, dosage forms and interactions of curcumin. Curcumin, the major bioactive component of turmeric, has low bioavailability due to its low water solubility, rapid metabolism in the liver and rapid excretion from the body. The main pathways of curcumin metabolism are described, including its reduction and subsequent conjugation with glucuronic acid and sulphates. Side effects of curcumin such as hyperoxaluria, iron deficiency anaemia, hepatotoxicity, arrhythmias, allergic reactions and potential carcinogenic properties are dis
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n K S, Sachi, Adlin Jino Nesalin J, and Tamizh Mani T. "Preparation and Evaluation of Curcumin Phytosomes by Rotary Evaporation Method." International Journal of Pharmacy and Biomedical Engineering 6, no. 1 (2019): 29–34. http://dx.doi.org/10.14445/23942576/ijpbe-v6i1p104.

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Prema, S., Firoj A. Tamboli, Bhupinder Bhyan, and Hanish Singh Jayasingh Chellammal. "Development and Evaluation of Polyherbal Phyto-phospholipid Complexes (Phytosomes) for PCOD Treatment." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 853–57. http://dx.doi.org/10.25258/ijddt.14.2.37.

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Tolycystic ovary disorder (PCOD) is a common endocrine condition affecting women of reproductive age that is distinguished by hyperandrogenism, ovulatory failure, and polycystic ovaries. It is still not entirely apparent what causes polycystic ovary syndrome (PCOS), and the treatments that are currently available tend to focus more on alleviating symptoms than on addressing the underlying causes. The bioavailability and effectiveness of bioactive chemicals can be improved by the use of phytosomes, which are sophisticated delivery methods. Phytosomes for the treatment of polycystic ovary syndro
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Košťálová, Daniela, Lýdia Bezáková, Lucia Račkovác, Silvia Mošovská, and Ernest Šturdík. "Therapeutic potential of curcumin in medicinal chemistry." Acta Chimica Slovaca 6, no. 1 (2013): 89–99. http://dx.doi.org/10.2478/acs-2013-0015.

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Abstract Extensive research over the past half century has shown that curcumin (diferuloylmethane), a polyphenolic compound of turmeric (Curcuma longa L.), can modulate multiple cell signaling pathways. Extensive clinical trials have addressed the pharmacokinetics, safety, and efficacy of this nutraceutical against numerous diseases in human. Curcumin, known for thousand years as a subject of Ayurvedic medicine, has undergone in recent times remarkable transformation into a drug candidate with prospective multipotent therapeutic application. Characterized by high chemical reactivity, resulting
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Mahapatra, Debarshi K., Shailendra Patil, and Asmita G. Patil. "The Progressive Journey of Phytosomes in Herbal Based Pharmacotherapeutics." Current Bioactive Compounds 16, no. 6 (2020): 853–86. http://dx.doi.org/10.2174/1573407215666190417121237.

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Background: The primary objective of any pharmacotherapeutics approach entirely lies with the effectiveness of the rationally designed delivery system to effectually deliver the suitable drug at the appropriate concentration at the proper site. Phytosomes are most effective carrier for the possible enhancement of bioavailability, reduction in the clearance rate, providing higher dissolution, and amplification of solubility by several folds of various natural products. Methods: The present review article focuses exclusively on the recent global advancements in the emerging novel drug delivery f
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Al-Rabia, Mohammed W., Nabil A. Alhakamy, Waleed Y. Rizg, Adel F. Alghaith, Osama A. A. Ahmed, and Usama A. Fahmy. "Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles." Drug Delivery 29, no. 1 (2022): 807–20. http://dx.doi.org/10.1080/10717544.2022.2048133.

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Marennavar, Santosh, Sakshi Shahapurmath, Shafin Paneri, Tanvi Nayak, Akshay K. Patil, and Sunil S. Jalalpure. "Incorporation of standardised extract of Curcuma longa Linn into phytosomes and its evaluation for in vitro Anti-inflammatory potential and Brine shrimp lethality assay." International Journal of Ayurvedic Medicine 15, no. 1 (2024): 111–16. http://dx.doi.org/10.47552/ijam.v15i1.4188.

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Aim: To incorporate standardized Curcuma longa Linn extract into phytosomes and evaluate for in vitro anti-inflammatory and BSL bioassay. Method: The quality of the plant material was determined by various pharmacognostic parameters. The plant material was then subjected to maceration for extraction using ethanol: water as solvent followed by Soxhlet extraction. The resulting extract was subjected to phytochemical analysis to determine the presence of plant metabolites. The drug and excipients compatibility was evaluated by FTIR study. Furthermore, using the thin film hydration approach, a new
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17

Bui, Tung. "Nghiên cứu bào chế curcumin dạng phytosome và dạng PEG hóa". VNU Journal of Science: Medical and Pharmaceutical Sciences 34, № 1 (2018): 29. http://dx.doi.org/10.25073/2588-1132/vnumps.4102.

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Curcumin có nhiều tác dụng dược lý quan trọng nhưng chưa được ứng dụng nhiều trên lâm sàng do sinh khả dụng thấp. Phytosome curcumin và PEG-CUR được nghiên cứu để tăng sinh khả dụng của curcumin. Phytosome curcumin được bào chế bằng phản ứng giữa curcumin và phosphatidylcholine. PEG-CUR được bào chế bằng phản ứng giữa curcumin và PEG. Phytosome curcumin và PEG-CUR được đánh giá hình thành liên kết thông qua kết quả phổ 1H NMR, FTIR and DSC. Một số đặc điểm hóa lý như thế zeta, độ phân bố kích thước, độ hòa tan và hàm lượng curcumin cũng được nghiên cứu. Hàm lượng curcumin trong phytosome curcu
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Nguyễn, Hồng Trang, Hữu Thành Phú Nguyễn, Thị Việt Hằng Trần та Nguyễn Phương Trang Lê. "Nghiên cứu ứng dụng Phytosome Curcumin vào viên nang cứng". Tạp chí Y Dược Huế 14, № 7 (2024): 86. https://doi.org/10.34071/jmp.2024.7.12.

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Đặt vấn đề: Hiện nay, nhu cầu sử dụng sản phẩm có nguồn gốc tự nhiên để dự phòng và điều trị bệnh ngày càng tăng. Do đó, các nghiên cứu về phytosome rất được quan tâm. Trong thời gian qua, Trường Đại học Y - Dược, Đại học Huế đã tiến hành nghiên cứu bào chế phytosome curcumin theo các phương pháp khác nhau. Trên cơ sở những kết quả thu được và với mong muốn tăng khả năng ứng dụng phytosome trên lâm sàng, nghiên cứu tiến hành ứng dụng phytosome curcumin vào dạng viên nang. Đối tượng và phương pháp nghiên cứu: Curcumin, lecithin và một số hóa chất khác được sử dụng. Bột phytosome curcumin được b
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Moradi-Marjaneh, Reyhaneh, Seyed M. Hassanian, Farzad Rahmani, Seyed H. Aghaee-Bakhtiari, Amir Avan, and Majid Khazaei. "Phytosomal Curcumin Elicits Anti-tumor Properties Through Suppression of Angiogenesis, Cell Proliferation and Induction of Oxidative Stress in Colorectal Cancer." Current Pharmaceutical Design 24, no. 39 (2019): 4626–38. http://dx.doi.org/10.2174/1381612825666190110145151.

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Background: Colorectal cancer (CRC) is one of the most common causes of cancer-associated mortality in the world. Anti-tumor effect of curcumin has been shown in different cancers; however, the therapeutic potential of novel phytosomal curcumin, as well as the underlying molecular mechanism in CRC, has not yet been explored. Methods: The anti-proliferative, anti-migratory and apoptotic activity of phytosomal curcumin in CT26 cells was assessed by MTT assay, wound healing assay and Flow cytometry, respectively. Phytosomal curcumin was also tested for its in-vivo activity in a xenograft mouse mo
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Liu, Nana, and Hongting Li. "Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease: A meta-analysis." Medicine 103, no. 52 (2024): e40538. https://doi.org/10.1097/md.0000000000040538.

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Background: Phytosomal curcumin may have some potential in improving anthropometric indices for nonalcoholic fatty liver disease, and this meta-analysis aims to study the effect of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease. Methods: We have searched several databases including PubMed, EMbase, Web of science, EBSCO and Cochrane library databases, and selected the randomized controlled trials (RCTs) comparing phytosomal curcumin with placebo for nonalcoholic fatty liver disease. This meta-analysis was conducted using the random-effect or fixed-effect mode
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Razzak, Rima Abdul, Mohammad Nadir Khan, and Amar Marwani. "Oral curcumin phytosome supplementation improves anthropometric measures of adiposity and enhances endothelial function in rats on a high-fat-diet regimen." Indian Journal of Physiology and Pharmacology 67 (December 29, 2023): 251–61. http://dx.doi.org/10.25259/ijpp_537_2022.

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Objectives: Curcumin has a protective role in endothelial function and nitric oxide (NO) production in animal models of different diseases; however, the role of curcumin on aortic reactivity in rats placed on a high-fat diet (HFD) remains unclear. This study aims to determine whether oral curcumin phytosome supplementation can reduce adiposity and enhance endothelial function. Materials and Methods: Rats were assigned to one of three groups: normal diet (ND), HFD for 20 weeks, and HFD supplemented with curcumin phytosome (HFD + Curcumin). Anthropometric measures were recorded weekly for the th
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Mirhafez, Seyed Reza, Azam Rezaei Farimani, Maryam Dehhabe, et al. "Effect of Phytosomal Curcumin on Circulating Levels of Adiponectin and Leptin in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial." Journal of Gastrointestinal and Liver Diseases 28 (June 1, 2019): 183–89. http://dx.doi.org/10.15403/jgld-179.

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Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with insulin resistance and changes in serum adipocytokine levels. The aim of the current study was to evaluate the effect of phytosomal curcumin on serum adiponectin and leptin levels in patients with NAFLD. Methods: In this randomized double-blind, placebo-controlled trial, 65 eligible patients were randomly allocated into curcumin and placebo recipient groups using a blocked randomized technique. Parameters of weight, height, body mass index (BMI), fasting blood sugar (FBS), lipid profile, aspartate aminotransfer
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Al Kahtani, Mohammed A. "Curcumin Phytosome Ameliorates Aluminum Chloride-Induced Nephrotoxicity in Rats." Egyptian Journal of Hospital Medicine 77, no. 3 (2019): 5143–47. http://dx.doi.org/10.21608/ejhm.2019.52403.

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Pajardi, Giorgio, Paola Bortot, Veronica Ponti, and Chiara Novelli. "Clinical Usefulness of Oral Supplementation with Alpha-Lipoic Acid, Curcumin Phytosome, and B-Group Vitamins in Patients with Carpal Tunnel Syndrome Undergoing Surgical Treatment." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/891310.

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We investigated the clinical usefulness of oral supplementation with a combination product containing alpha-lipoic acid, curcumin phytosome, and B-group vitamins in 180 patients with carpal tunnel syndrome (CTS), scheduled to undergo surgical decompression of the median nerve. Patients in Group A (n=60) served as controls and did not receive any treatment either before or after surgery. Patients in Group B (n=60) received oral supplementation twice a day for 3 months both before and after surgery (totaling 6 months of supplementation). Patients in Group C (n=60) received oral supplementation t
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Sbrini, Giulia, Paola Brivio, Enrico Sangiovanni, et al. "Chronic Treatment with a Phytosomal Preparation Containing Centella asiatica L. and Curcuma longa L. Affects Local Protein Synthesis by Modulating the BDNF-mTOR-S6 Pathway." Biomedicines 8, no. 12 (2020): 544. http://dx.doi.org/10.3390/biomedicines8120544.

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Brain derived neurotrophic factor (Bdnf) is the most diffuse neurotrophin in the central nervous system and it is crucial for the proper brain development and maintenance. Indeed, through the binding to its high affinity receptor TRKB and the activation of different intracellular cascades, it boosts cell survival, neurite growth and spine maturations mechanisms. Here, we evaluated if the chronic oral treatment for 10 days with a phytosomal preparation containing Centella asiatica L. and Curcuma longa L. could improve Bdnf levels in the prefrontal cortex of adult rats. Interestingly we found an
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Pivari, Francesca, Alessandra Mingione, Giada Piazzini, et al. "Curcumin Supplementation (Meriva®) Modulates Inflammation, Lipid Peroxidation and Gut Microbiota Composition in Chronic Kidney Disease." Nutrients 14, no. 1 (2022): 231. http://dx.doi.org/10.3390/nu14010231.

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Chronic kidney disease (CKD) subjects suffer from high risk of cardiovascular mortality, and any intervention preventing the progression of CKD may have an enormous impact on public health. In the last decade, there has been growing awareness that the gut microbiota (GM) can play a pivotal role in controlling the pathogenesis of systemic inflammatory state and CKD progression. To ameliorate the quality of life in CKD subjects, the use of dietary supplements has increased over time. Among those, curcumin has demonstrated significant in vitro anti-inflammatory properties. In this pilot study, 24
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Mancillas-Quiroz, Jose Antonio, Miriam del Carmen Carrasco-Portugal, Karina Mondragón-Vásquez, et al. "Development of a Novel Co-Amorphous Curcumin and L-Arginine (1:2): Structural Characterization, Biological Activity and Pharmacokinetics." Pharmaceutics 17, no. 1 (2024): 11. https://doi.org/10.3390/pharmaceutics17010011.

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Background: Curcumin appears to be well tolerated and effective for managing chronic inflammatory pain, but its poor oral bioavailability has been a hurdle in its use as a therapeutic agent. The current study was performed to characterize a novel co-amorphous compound based on curcumin/L-arginine 1:2 (CAC12). Methods: Stability, solubility and structural characterization of the CAC12 were carried out by spectrometry techniques and in vitro assays, whereas the antinociceptive and anti-inflammatory effects were evaluated by CFA or carrageenan models. The mechanism of action was determined by cyt
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Mirzaei, Hamed, Abolfazl Shakeri, Bahman Rashidi, Amin Jalili, Zarrin Banikazemi, and Amirhossein Sahebkar. "Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies." Biomedicine & Pharmacotherapy 85 (January 2017): 102–12. http://dx.doi.org/10.1016/j.biopha.2016.11.098.

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Marjaneh, Reyhaneh Moradi, Farzad Rahmani, Seyed Mahdi Hassanian, et al. "Phytosomal curcumin inhibits tumor growth in colitis-associated colorectal cancer." Journal of Cellular Physiology 233, no. 10 (2018): 6785–98. http://dx.doi.org/10.1002/jcp.26538.

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Zhang, Jifen, Qin Tang, Xiaoyu Xu, and Na Li. "Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery." International Journal of Pharmaceutics 448, no. 1 (2013): 168–74. http://dx.doi.org/10.1016/j.ijpharm.2013.03.021.

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Giacosa, Attilio, Antonella Riva, Giovanna Petrangolini, et al. "Beneficial Effects on Abdominal Bloating with an Innovative Food-Grade Formulation of Curcuma longa and Boswellia serrata Extracts in Subjects with Irritable Bowel Syndrome and Small Bowel Dysbiosis." Nutrients 14, no. 3 (2022): 416. http://dx.doi.org/10.3390/nu14030416.

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Bloating is a symptom frequently reported by subjects with irritable bowel syndrome (IBS) and small bowel dysbiosis, and Low FODMAP’s diet (LFD) has been used to treat them. Extracts of Curcumalonga and Boswelliaserrata share anti-inflammatory and antimicrobial effects that could be useful in the management of these clinical conditions. The aim of this study was to evaluate the efficacy of curcumin and boswellia extracts (as Curcumin Boswellia Phytosome, CBP) and LFD on the relief of abdominal bloating in IBS subjects with small bowel dysbiosis, in comparison to LFD alone, in a 30-day suppleme
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Pires, José Mateus, Gabriella Farias Lopes, Caroline Ribeiro de Sousa, et al. "Use of phytotherapy in treating diabetic foot in older adults: an integrative review." Rev Rene 24 (July 5, 2023): e85110. http://dx.doi.org/10.15253/2175-6783.20232485110.

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Objective: to identify the scientific evidence on herbal medicines used in treating diabetic foot in older adults. Methods: an integrative review conducted in the Medical Literature Analysis and Retrieval System, SCOPUS, EMBASE, Web of Science and Latin American and Caribbean Health Sciences Literature databases. The Rayyan platform was used as a supporting tool for archiving, organizing and selecting articles. Results: the search resulted in 158 articles. After identifying, selecting, evaluating eligibility, systematization and performing a full reading of the articles, the final sample consi
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Al-Kahtani, Mohammed, Mohamed M. Abdel-Daim, Amany A. Sayed, Attalla El-Kott, and Kareem Morsy. "Curcumin phytosome modulates aluminum-induced hepatotoxicity via regulation of antioxidant, Bcl-2, and caspase-3 in rats." Environmental Science and Pollution Research 27, no. 17 (2020): 21977–85. http://dx.doi.org/10.1007/s11356-020-08636-0.

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Ali, Shimaa Omar, Hebatallah Abd El-moeti Darwish, and Nabila Abd El-fattah Ismail. "Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats." Chemico-Biological Interactions 216 (June 2014): 26–33. http://dx.doi.org/10.1016/j.cbi.2014.03.009.

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Panahi, Yunes, Parisa Kianpour, Reza Mohtashami, Ramezan Jafari, Luis Simental-Mendía, and Amirhossein Sahebkar. "Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial." Drug Research 67, no. 04 (2017): 244–51. http://dx.doi.org/10.1055/s-0043-100019.

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Nosratabadi, Reza, MohammadReza Rahmani, Mahnaz Ramezani, et al. "Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats." Asian Pacific Journal of Tropical Biomedicine 12, no. 11 (2022): 466. http://dx.doi.org/10.4103/2221-1691.360562.

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Hashemzehi, Milad, Reihane Behnam‐Rassouli, Seyed Mahdi Hassanian, et al. "Phytosomal‐curcumin antagonizes cell growth and migration, induced by thrombin through AMP‐Kinase in breast cancer." Journal of Cellular Biochemistry 119, no. 7 (2018): 5996–6007. http://dx.doi.org/10.1002/jcb.26796.

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38

Baradaran, Saeideh, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani Jelodar, and Nasroallah Moradi-kor. "Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses." Journal of Inflammation Research Volume 13 (January 2020): 45–51. http://dx.doi.org/10.2147/jir.s232462.

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39

Saharkhiz, Mansoore, Malaksima Ayadilord, Fariba Emadian Razavi, and Mohsen Naseri. "Effects of phytosomal curcumin treatment on modulation of immunomodulatory and pulp regeneration genes in dental pulp mesenchymal stem cells." Odontology 110, no. 2 (2021): 287–95. http://dx.doi.org/10.1007/s10266-021-00659-4.

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40

Nova, Riki, and Dessy Abdullah. "CURCUMA XANTHORRHIZA ROXB. DALAM MANAJEMEN KESEHATAN PENCERNAAN : INTEGRASI PERSPEKTIF BIOMEDIK, GENOMIK, DAN ETNOMEDISIN INDONESIA." Journal of Public Health Science 2, no. 1 (2025): 118–25. https://doi.org/10.70248/jophs.v2i1.2287.

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Penelitian ini bertujuan untuk mengevaluasi potensi Curcuma xanthorrhiza Roxb. (temulawak) dalam manajemen gangguan pencernaan dengan mengintegrasikan pendekatan biomedik molekuler, genomik, dan etnomedisin Indonesia. Metode penelitian yang digunakan berupa kajian literatur sistematis yang mengikuti pedoman PRISMA, dengan penelusuran data dari empat basis data utama (PubMed, Scopus, ScienceDirect, dan Garuda) untuk publikasi antara tahun 2013 hingga 2023. Artikel yang memenuhi kriteria inklusi, seperti studi preklinis, klinis, in silico, dan etnofarmakologi, diseleksi dan dievaluasi kualitasny
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41

Ali, Shimaa O., Hebatallah A. Darwish та Nabila A. Ismail. "Curcumin, Silybin Phytosome®and α-R-Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production". Basic & Clinical Pharmacology & Toxicology 118, № 5 (2015): 369–80. http://dx.doi.org/10.1111/bcpt.12502.

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Wagnon, Ingrid, Garry Niedermayer, Gerald Muench, Tim Karl, Rose Chesworth, and Erika Gyengesi. "EFFECTS OF A LONG-TERM PHYTOSOMAL CURCUMIN DIET ON COGNITIVE FUNCTIONS AND INFLAMMATORY MARKERS IN A MOUSE MODEL OF CHRONIC NEUROINFLAMMATION." IBRO Neuroscience Reports 15 (October 2023): S514—S515. http://dx.doi.org/10.1016/j.ibneur.2023.08.1011.

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43

Pastorelli, Davide, Aline S. C. Fabricio, Petros Giovanis, et al. "Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial." Pharmacological Research 132 (June 2018): 72–79. http://dx.doi.org/10.1016/j.phrs.2018.03.013.

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44

Cicero, A., A. Sahebkar, F. Fogacci, M. Bove, M. Giovannini, and C. Borghi. "Effects Phytosomal Curcumin On Anthropometric Parameters, Insulin-Resistance, Cortisolemia And Non-Alcoholic Fatty Liver Disease Indexes: A Double-Blind, Placebo-Controlled Clinical Trial." Atherosclerosis 287 (August 2019): e149. http://dx.doi.org/10.1016/j.atherosclerosis.2019.06.443.

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45

Moradi-Marjaneh, Reyhaneh, Seyed M. Hassanian, Farzad Rahmani, Seyed H. Aghaee-Bakhtiari, Amir Avan, and Majid Khazaei. "Retraction Notice to “Phytosomal Curcumin Elicits Anti-tumor Properties Through Suppression of Angiogenesis, Cell Proliferation and Induction of Oxidative Stress in Colorectal Cancer”." Current Pharmaceutical Design 31, no. 34 (2025): 2783. https://doi.org/10.2174/1381612831999250617093855.

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This article titled “Phytosomal Curcumin Elicits Anti-tumor Properties Through Suppression of Angiogenesis, Cell Proliferation and Induction of Oxidative Stress in Colorectal Cancer”, published in Volume 24, Issue 39, 2018 of Current Pharmaceutical Design (10.2174/1381612825666190110145151) has been retracted by the publisher following a thorough investigation that revealed potential data manipulation in the manuscript. As a result, the integrity and validity of the data presented could not be confirmed. This article has been retracted at the request of the Editor-in-Chief and the Publisher du
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Cicero, Arrigo F. G., Amirhossein Sahebkar, Federica Fogacci, Marilisa Bove, Marina Giovannini, and Claudio Borghi. "Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial." European Journal of Nutrition 59, no. 2 (2019): 477–83. http://dx.doi.org/10.1007/s00394-019-01916-7.

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Giacosa, Attilio, Gaetan Claude Barrile, Simone Perna, and Mariangela Rondanelli. "Positive Outcomes of Supplementation with Lecithin-Based Delivery Formulation of Curcuma longa and Boswellia serrata in IBS Subjects with Small Bowel Dysbiosis." Life 14, no. 11 (2024): 1410. http://dx.doi.org/10.3390/life14111410.

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Background: Small bowel dysbiosis (SBD) is a frequent finding in subjects with irritable bowel syndrome (IBS). The sunflower lecithin (phytosome) formulation of Curcuma longa and Boswellia serrata demonstrated beneficial effects on intestinal microbiota. This study aimed to evaluate the impact of a lecithin-based delivery formulation of Curcuma longa and Boswellia serrata extracts (CUBO) on SBD in IBS subjects. Subjects: Forty-nine adult subjects with IBS and SBD were randomly supplemented for 30 days with CUBO and a low-FODMAP diet (LFD) (intervention) or with LFD and placebo (control group).
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Kothawade, Sachin, Manjusha Bhange, and Vishal Vijay Pande. "Advancements in Phytosomal Therapies for Liver Cancer: A Comprehensive Review." Current Cancer Drug Targets 24 (September 23, 2024). http://dx.doi.org/10.2174/0115680096319007240703072650.

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Phytosomes, innovative lipid-compatible complexes formed by combining natural phospholipids with water-soluble phytoconstituents, represent a groundbreaking technology in herbal medicine. This review examines the novel applications of phytosomes in liver cancer treatment. Phytosome technology overcomes traditional obstacles in utilizing herbal potential for modern medicine, such as issues with potency, solubility, permeability, and stability, which has led to increased interest in herbal drug sources. By enhancing the bioavailability and bioefficacy of polyphenolic phytoconstituents, particula
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Kondumahanti, V. N. Lakshmi, Satya Jaya Krishna Reddy Nallamilli, and Narendra Devanaboyina. "Nature Meets Nanotechnology: Evolution of Phytosomes." International Journal of Pharmaceutics and Drug Analysis, June 24, 2025, 26–34. https://doi.org/10.47957/ijpda.v13i2.628.

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Since ancient times, herbal plants have served as traditional medicines for the treatment of various diseases. These herbal plants contain phyto constituents that have excellent pharmacological activity and bioactivity and help in the management of diseases like cancer, liver damage, inflammation, and heart disease. The supply of these phytomedicinals, which have some physicochemical limitations such as poor absorbability and bioavailability due to their multiple ring structures and poor solubility. Phytosome technology was introduced to overcome the physicochemical limitations of herbal medic
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Singh, Deepak, and Prashant Upadhyay. "Antiinflammatory and Wound Healing Activity of Curcumin containing Phytosomes, Niosomes and Liposomes in rats." Research Journal of Pharmacy and Technology, June 26, 2023, 2776–78. http://dx.doi.org/10.52711/0974-360x.2023.00456.

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Curcumin is obtained from Curcuma longa, it possesses various pharmaceutical activities like antiinflammatory, wound healing, anti-cancer, etc. But low aqueous solubility and stability problems limit its use in pharmaceutical formulations. Nanocarriers like phytosomes, niosomes, and liposomes improve solubility and stability problems of curcumin. Curcumin's anti-inflammatory and wound-healing properties were investigated in this study using nanocarriers (phytosomes, niosomes, and liposomes).
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