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Dissertations / Theses on the topic 'Curcumine – Analogues'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Jourdan, Jean-Pierre. "Conception, synthèse et évaluation biologique de nouveaux analogues de la curcumine : potentiels agents pléiotropes d'intérêt thérapeutique dans la maladie d'Alzheimer." Caen, 2015. http://www.theses.fr/2015CAEN4012.

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La maladie d’Alzheimer, forme la plus commune des démences séniles, est une maladie progressive, chronique, neurodégénérative et irréversible. Les causes physiopathologiques de cette démence sont nombreuses. Parmi elles on peut citer l’agrégation de peptides β-amyloïdes, l’hyperphosphorylation de la protéine Tau, l’inflammation neuronale et le stress oxydatif. Une des approches thérapeutiques récemment développées pour modifier l’évolution de cette maladie multifactorielle est la conception de ligands multicibles. On trouve dans la nature des molécules douées de telles fonctions, dont la curcu

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2

Pecourneau, Jérémy. "Réponses photoinduites d'analogue biomimétique de la cyclocurcumine : vers des thérapies assistées par la lumière." Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0205.

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Au-delà de la thérapie photodynamique (PDT), il existe plusieurs alternatives thérapeutiques assistées par la lumière parmi lesquelles la thérapie photothermique (PTT) ou encore la photoisomérisation dont l’action mécanique induirait des dommages cellulaires au sein des membranes. De plus, les molécules capables d’absorber simultanément deux photons permettraient de surmonter la nécessité d’une excitation à haute énergie par photon tout en gardant une pénétration suffisante des tissus. Dans ce contexte, nous nous sommes intéressés à la conception et à l’étude d’analogues biomimétiques de la cy

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3

Schmitt, Bonell. "Curcumin analogues as ligands for Re (I) and (V)." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/d1020975.

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Coordination properties of 4-bromo-N-(diethylcarbamothioyl)benzamide (Hbeb) and 4-bromo-N-(diphenylcarbamothioyl)benzamide (Hbpb) with oxorhenium(V) and rhenium(I) are reported and discussed. Transition metal complexes of these ligands were studied due to the wide range of applications of thiourea derivatives in biological fields. N-[Di(alkyl/aryl)carbamothioyl]benzamide derivatives readily coordinate to metal ions as O,S-donors and the catalytic property of the complexes can be altered by these ligands, due to steric and electronic properties provided by various substituents. The coordination

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4

Souza, Nayane de. "Efeitos citotóxicos do DM-1 em células de melanoma resistentes a um inibidor de BRAF e na expressão de metaloproteinases." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9143/tde-06122017-105135/.

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Melanoma é o câncer mais agressivo e a mutação BRAF V600E é a mais frequente entre os pacientes. O vemurafenibe foi o primeiro inibidor específico desta mutação aprovado pela Food and Drug Administration. Entretanto, após cerca de seis meses há recidiva e superar os mecanismos de resistência responsáveis por este fenômeno ainda é um desafio. A curcumina é um tumérico com características antitumorais e anti-inflamatórias, entretanto sua baixa biodisponibilidade e estabilidade limitam seu uso e por isso impulsionaram a busca por análogos capazes de serem eficientes e comercializados. O DM-1, é u

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5

Al-shdifat, Laith Mohammad Hilal. "Approaches to Enhancing the Properties of a Promising Curcumin Analogue." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25786.

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A range of derivatives has previously been synthesized in order to overcome the stability and pharmacokinetic hurdles that hinder the in vivo investigation of the natural product, curcumin. One such derivative, pyrazole 15, has been demonstrated to inhibit the proliferation of a highly metastatic androgen-independent prostate cancer cell line (PC3). In this work, pyrazole analogues, 15 and 32 and the corresponding curcumin analogues, 30 and 31 were synthesized using a microwave-assisted technique. A stability study, and in silico assessment, of curcumin 1 and thirteen pyrazole analogues (15,1

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6

Abdelhamid, Dalia. "Natural Products as Lead Compounds for Drug Development. Part I: Synthesis and Biological Activity of a Structurally Diverse Library of Curcumin Analogues. Part II: Synthesis of Novel Sterol Natural Products and Related Analogues as Antileishmanial Ag." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299685922.

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7

Tedesco, Serena. "Activation phenotypes of human monocyte-derived macrophages: methodological approaches and pharmacological modulation by curcumin analogues." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3427229.

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Under normal conditions macrophages provide immune surveillance and host defense in tissues to maintain homeostasis. However, upon sensing changes in the microenvironment, macrophages become activated, undergoing a morphological and functional switch. Activation of these cells is not an “all-or-none” process, but rather a continuum characterized by a wide spectrum of molecular and functional phenotypes ranging from the “classical” M1 activated phenotype, with a highly pro-inflammatory profile, to the “alternative” M2 phenotype, associated with a beneficial, less inflammatory, protective profil

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8

SINGH, REETIKA. "COMPARATIVE ANALYSIS OF DIFFERENT CURCUMIN ANALOGUES TO INHIBIT TLR4 EXPRESSION IN BREAST CANCER- AN IN-SILICO STUDY." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18459.

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Chronic inflammation is closely related to the emergence of a number of cancers, including Breast cancer. Inflammation causes damage to the cell’s DNA which leads to its abnormal growth and formation of tumor mass. One of the most commonly known receptor responsible for inflammatory reactions is Toll-like receptor 4 (TLR4). It is activated majorly by bacterial LPS. Its activation further activates Cyclooxygenase enzyme that catalyzes the conversion of arachidonic acid into prostaglandins that lead to inflammation-like conditions. COX2 has also been correlated to the promotion of tumor g

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9

"INVESTIGATING THE MASS SPECTROMETRIC BEHAVIOR OF NOVEL ANTINEOPLASTIC CURCUMIN ANALOGUES." Thesis, 2015. http://hdl.handle.net/10388/ETD-2015-01-1911.

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Curcumin analogues are novel antineoplastic agents designed by structural modifications of the natural product curcumin to enhance its therapeutic effects. Various curcumin analogues displayed a significant cytotoxic effect towards different cancer cell lines including leukemia, melanoma, and colon cancer. In order to evaluate the safety, efficiency and metabolism of the new anticancer candidates, sensitive and high throughput analytical methods are needed. Thirteen curcumin analogues with the backbone structure of 3,5-bis(benzylidene)-4-piperidone were tested. The ionization behavior of curcu

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10

Ze, Chen Chu, та 陳楚澤. "Xanthine Oxidase and α-Glucosidase Inhibition of Curcumin and Curcumin Analogs". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/y83s8x.

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碩士<br>輔仁大學<br>食品科學系碩士班<br>103<br>Curcumin is a constituent from root and stem of family Zingiberaceae and Araceae. It has been used as a natural colorant in food industry. Curcumin has a great value in food and medicine, and it has been reported that curcumin could inhibit the activities of xanthine oxidase (XO) and α-glucosidase that make curcumin can be used for treatment of gout and diabetes. Chemical synthesis, which can change the structure of component, can enhance the activities, even create a new one. Therefore, the objective of this research is to evaluate the characterization of curc

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11

Ou, Jun-Lin, and 歐俊麟. "Comparative analysis of curcumin analogues on anti-influenza virus activity." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/32377636392422952105.

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碩士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>101<br>Curcumin is a commonly used colouring agent and spice in food. Accumulated evidence indicates that curcumin is associated with a great variety of pharmacological activities, including an antimicrobial effect. Previously, we reported curcumin inhibits the infection of type A influenza virus (IAV) and proved one of the mechanisms is through interfering the viral HA activity. To investigate the structure contributing to its anti-IAV activity, structural and functional analogues of Curcumin (Cur), such as Tetrahydrocurcumin (THC), Monoacetylcurcumin (MAC) and

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12

Chen, Yong-Song, and 陳永崧. "Synthesis and anticancer activity of curcumin analogs." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/4qcnpg.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>102<br>Curcumin is an orange-yellow crystalline powder obtained from rhizome of Curcuma longa Linn (Zingiberaceae). Curcumin has a variety of biological activities. Within the past 30 years, cancer is a leading cause of death in Taiwan. Therefore, developing new anticancer drugs is in an urgent need. In the recent years, there are many studies reported that curcumin displayed anticancer activity. In this study, several curcumin analogs were synthesized and evaluated for anticancer activities. We expected to find a better anticancer agent than curcumin. This study

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13

"In vitro studies using curcumin and curcumin analogues as candidate mitochondria-targeting anticancer agents affecting colon cancer cells." Thesis, 2014. http://hdl.handle.net/10388/ETD-2014-09-1714.

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Curcumin is one of the major curcuminoids produced by the ginger family Zingiberaceae. These curcuminoids possess pharmacological properties that include anticancer activities. We have evaluated some synthetic curcumin analogues that have shown potential as anticancer drugs. These antineoplastic agents bearing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore are electrophiles which are designed to preferentially react with sulfhydryl groups present in proteins as opposed to amino and hydroxyl groups present in DNA. In previous pilot studies, three derivatives examined in this thesis showed i

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14

KUO, YU-LING, та 郭育伶. "Preparation and characterization of zein-curcumin analogue nanoparticles with α-glucosidase and xanthine oxidase inhibitory activities". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/7kg9yk.

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碩士<br>輔仁大學<br>食品科學系碩士班<br>107<br>Curcumin (CM) is a natural lipophilic polyphenol with a variety of pharmacological properties, that provide antioxidizing, antiinflammatory, antimicrobial, antiviral, antirheumatic, anticancer, and neuroprotective effects. However, curcumin is limited in terms of water-solubility, and curcumin analogues as well. Researchers have recently begun using biopolymers to encapsulate hydrophobic compounds in order to improve their bioavailability. The objective of this study was to evaluate the feasibility of using zein nanoparticles as an oral delivery vehicle for cur

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15

Li, Cho-Han, and 李卓涵. "Studies on Curcumin and its analogs on anti-metastatic activities of human fibrosarcoma cells (HT-1080)." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/00651349802485252607.

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碩士<br>臺北醫學大學<br>生藥學研究所<br>97<br>Curcumin, a yellowish pigment existed in turmeric plant has been shown to exhibit numerous biological properties, such as anti-inflammation, antioxidation, anti-invasion, and antimetastatic activity. Chemical modifications of curcumin have been studied intensively in an attempt to find an analog with similar but enhanced biological activities of curcumin. In literatures, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA) played important roles in cancer cell invasion by hydrolysing extracellular matrix (ECM). In this study, curcumin and 2

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16

Chiang, Ting-Hsuan, and 江庭萱. "Studies on curcumin and its analogs on apoptotic activities in human breast adenocarcinoma cells (MCF-7 and MDA-MB-231)." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/57106318055398201666.

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碩士<br>臺北醫學大學<br>生藥學研究所<br>98<br>Curcumin is the primary bioactive constituent of turmeric, which is an herbal medicine used in Asia for a long time. It has been shown to possess anti-inflammatory, antioxidant, anti-metastatic, and apoptosis- induced properties. In this study, curcumin and 23 different kinds of curcumin analogs were evaluated for cytotoxicity effects on two breast cancer cell lines—MCF-7 and MDA-MB-231. According to the results of cell viability assay, analog 2, 6 and 85 showed stronger growth inhibition activities in both MCF-7 and MDA-MB-231 cell lines than curcumin under con

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17

Huang, Yu-Wei, and 黃昱瑋. "Study on the effects of curcumin and its analogs on the protection of hydrogen peroxide-treated human immortalized keratinocyte cell line (HaCaT)." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/gbbegy.

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碩士<br>臺北醫學大學<br>生藥學研究所<br>102<br>Hydrogen peroxide can produce large amounts of intracellular reactive oxygen species (reactive oxygen species, ROS) which can cause oxidative stress in cells. Many diseases and skin aging are associated with oxidative stress in cells. To find out which drug can reduce intracellular oxidative stress, hydrogen peroxide is used to treat cells for drug screenings. Curcumin, a polyphenol in turmeric, it has been reported to have various biological activities. In this study, we used curcumin and its analogs as materials to find out the protective activities against

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