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Journal articles on the topic 'Cure Residual Strain (CRS)'

Author: Grafiati

Published: 6 September 2023

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1

Hamed, G. R., and K. Umetsu. "Gum and Black-Filled Double Networks of cis-1,4-Polyisoprene Crosslinked with Sulfur Donors: Part I. Tensile Properties." Rubber Chemistry and Technology 78, no. 1 (2005): 130–42. http://dx.doi.org/10.5254/1.3547866.

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Abstract Gum and black-filled double networks of cis-1,4 polyisoprene, crosslinked with sulfur donors, have been prepared by first partially curing sheets, then stretching them and completing cure. Double networks are anisotropic and exhibit a residual extension ratio λr, which is higher for filled compared to gum samples. Additionally, double networks of filled specimens have higher anisotropy than gum counterparts, presumably because carbon black promotes chain alignment and strain-crystallization. Tensile specimens cut parallel to the stretch direction are stiffer, less extensible, and some

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2

Takagaki, Kazunori, Shinsaku Hisada, Shu Minakuchi, and Nobuo Takeda. "Process improvement for out-of-autoclave prepreg curing supported by in-situ strain monitoring." Journal of Composite Materials 51, no. 9 (2016): 1225–37. http://dx.doi.org/10.1177/0021998316672001.

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Vacuum-bag-only curing is an attractive out-of-autoclave method as an alternative to conventional autoclave curing. Previous extensive researches provided great insight into void formation during the vacuum-bag-only method and these findings are reflected in current vacuum-bag-only cure cycles to minimize void content. Cure process can be further improved by taking into consideration cure-induced residual stress/strain. The present paper proposed a residual stress/strain reduction method and evaluated its effectiveness using a commercially available vacuum-bag-only material by fiber-optic-base

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3

Jiang, Cheng Biao, Li Hua Zhan, Xiao Bo Yang, Xiao Ping Chen, Zi Jun Lin, and Cheng Long Guan. "Monitoring of Multidirectional and Cure-Induced Strain in CFRP Laminates Using FBG Sensors." Materials Science Forum 953 (May 2019): 72–79. http://dx.doi.org/10.4028/www.scientific.net/msf.953.72.

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During the curing cycle, the residual stress has influence on cure-induced deformation for carbon fiber reinforced plastics (CFRP) laminates, which is highly susceptible to the ply design. Therefore, the change laws of strain and the effect of residual stress in CFRP laminates after curing, which is of great significance to ply design, were cleared by using the combining pattern of thermocouple and fibre Bragg grating (FBG) sensors. For the FBG sensors embedded with different directions in lay-up CFRP laminates, the temperature and strain in different directions of composite laminates were obt

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4

Drake, Daniel A., Rani W. Sullivan, Jonathan E. Spowart, and Katie Thorp. "Influence of cure parameters in polymer matrix composites using embedded optical fibers." Journal of Composite Materials 54, no. 19 (2020): 2611–21. http://dx.doi.org/10.1177/0021998319899153.

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The influence of cure processing parameters was investigated using strain distributions from embedded optical fibers. The determination of optimized cure parameters is often needed to achieve material properties which meet aerospace industry design requirements. Optical fibers were embedded near the midplane of thin (5 mm; [0/90/90/0]3s) composite laminates to monitor the internal strain during cure for two different cure cycles (manufacturer-recommended and an alternative two-step cure). Each laminate was fabricated using a vacuum-assisted resin transfer molding process. The internal strain w

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Lee, Soo Yong, and Jung Sun Park. "Chemical Shrinkage and Residual Stresses in Laminated Composites during Cure." Key Engineering Materials 297-300 (November 2005): 2870–75. http://dx.doi.org/10.4028/www.scientific.net/kem.297-300.2870.

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The residual stress that occurs in fiber-reinforced thermosetting composite materials during cure is one of the severe factors that can deteriorate the performance of composite structures. To investigate residual stresses occurring in laminated composites during cure, an incremental viscoelastic constitutive equation is derived as a function of temperature, degree of cure and chemical shrinkage. A finite element program is developed on the basis of a 3-D degenerated shell element and the first order shear deformation theory. Experiments were performed to measure the coefficients of chemical sh

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Gasser, Elisabeth, Pamela Kogler, Andreas Lorenz, Reinhold Kafka-Ritsch, Dietmar Öfner, and Alexander Perathoner. "Do we still need CRS and HIPEC in colorectal cancer in times of modern chemotherapy and immunotherapy?" memo - Magazine of European Medical Oncology 13, no. 4 (2020): 430–33. http://dx.doi.org/10.1007/s12254-020-00647-4.

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SummaryPeritoneal carcinomatosis from colorectal cancer is associated with a poor prognosis and is usually treated with systemic chemotherapy and immunotherapy alone. In patients with isolated peritoneal carcinomatosis (PC) without nonperitoneal metastases, however, cytoreductive surgery (CRS) has been shown to significantly improve outcome and to achieve even cure in selected patients in combination with systemic therapy. The additional use of a hyperthermic intraperitoneal chemotherapy (HIPEC) is primarily indicated to control microscopical residual tumor tissue in the peritoneal cavity afte

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Antonucci, V., A. Cusano, M. Giordano, J. Nasser, and L. Nicolais. "Cure-induced residual strain build-up in a thermoset resin." Composites Part A: Applied Science and Manufacturing 37, no. 4 (2006): 592–601. http://dx.doi.org/10.1016/j.compositesa.2005.05.016.

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8

Ifju, P. G., X. Niu, B. C. Kilday, S. C. Liu, and S. M. Ettinger. "Residual strain measurement in composites using the cure-referencing method." Experimental Mechanics 40, no. 1 (2000): 22–30. http://dx.doi.org/10.1007/bf02327544.

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9

Crasto, Allan S., Ran Y. Kim, and John D. Russell. "In situ monitoring of residual strain development during composite cure." Polymer Composites 23, no. 3 (2002): 454–63. http://dx.doi.org/10.1002/pc.10447.

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10

Edward, Aghogho Bright, P. Stephan Heyns, and Schalk Kok. "A Numerical Investigation of a Single-Shot in a DEM-FEM Approach to Shot Peening Simulation." Metals 9, no. 11 (2019): 1183. http://dx.doi.org/10.3390/met9111183.

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Shot peening (SP) is a controlled and systematic process of surface treatment that has a large number of controllable process parameters that make its application highly challenging. It involves the shooting of small and hard metallic balls at a targeted surface, with the aim of enhancing the fatigue strength of the workpiece under unfavorable service conditions. The compressive residual stress (CRS) induced by this application is expensive to evaluate experimentally. This paper presents a numerical model of the impact of a single-shot on a metallic surface, with the aim to set the stage for a

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Zou, Ai Hua, Xian Liang Zhou, Duo Sheng Li, and Xiao Zhen Hua. "Effects of Mg and Si in Al Matrix on Dimensional Stability of SiC_p/Al Composites during Temperature Change." Advanced Materials Research 631-632 (January 2013): 335–40. http://dx.doi.org/10.4028/www.scientific.net/amr.631-632.335.

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In this paper, based on the parameters of cumulative residual strain(CRS), the effects of different contents of Mg and Si elements in Al matrix on the dimensional stability of SiCp/Al composites was investigated and analyzed in the temperature interval of 25～400°C. Results show that，with the increasing of Si content in Al matrix, the CRS fluctuates only in a small range of strain, adding Si in Al matrix is beneficial to the dimensional stability of the composites, which can be improved through pre-thermal cycling; with the increasing of Mg content in Al matrix, the absolute value of negative C

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12

Lee, Sang Il, Dong Jin Yoon, Seung Seok Lee, and Joung Man Park. "Cure Monitoring and Stress-Strain Sensing of Single-Carbon Fiber Composites by the Measurement of Electrical Resistance." Key Engineering Materials 297-300 (November 2005): 676–84. http://dx.doi.org/10.4028/www.scientific.net/kem.297-300.676.

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Cure monitoring and stress-strain sensing of single-carbon fiber composites were nondestructively evaluated by the measurement of electrical resistance. The difference of electrical resistance before and after curing increased highest when gauge length of the specimen was the smallest. As curing temperature increased, the electrical behavior of steel fiber was different from that of semi-conductive carbon and SiC fibers. Residual stress built in the fiber was the highest at the fiber axis direction. Whereas residual stress built in the matrix was relatively high at the fiber circumference and

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13

Li, Xue Qin, Zi Long Zhang, and Xiao Su Yi. "Monitoring and Characterization of Chemical Shrinkage during Curing in a RTM Resin." Advanced Materials Research 476-478 (February 2012): 2594–98. http://dx.doi.org/10.4028/www.scientific.net/amr.476-478.2594.

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Chemical cure shrinkage of polymer matrix is a significant source of residual strain formation in composite products during curing. In this paper, fiber Bragg grating (FBG) sensors were used to monitor the free strain development caused by chemical shrinkage and compared with results of differential scanning calorimetry and rheological analysis. The results showed that the gel point could be clearly identified by FBG sensors and compressive residual strain of around 800με was caused by isothermal curing reaction after gelation. The relationship between the chemical shrinkage ratio and conversi

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14

Namsone, Endija. "INVESTIGATION OF RESIDUAL STRESSES AND DEFORMATIONS OF A PULTRUDED THIN BEAM PROFILE." ENVIRONMENT. TECHNOLOGIES. RESOURCES. Proceedings of the International Scientific and Practical Conference 3 (June 16, 2021): 232–35. http://dx.doi.org/10.17770/etr2021vol3.6635.

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In the present study, a coupled 3D transient thermo-chemical analysis together with 2D plane strain mechanical analysis is carried out for the pultrusion process. For the mechanical analysis, a cure hardening instantaneous linear elastic (CHILE) approach is used of a thin beam profile made of glass fibre and epoxy resin. The applied approach is efficient and fast to investigate the residual stresses and deformations together with the distributions of temperature and degree of cure obtained from the thermo-chemical analysis.

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15

Pupure, Liva, Sibin Saseendran, Janis Varna, and Margherita Basso. "Effect of degree of cure on viscoplastic shear strain development in layers of [45/−45]s glass fibre/ epoxy resin composites." Journal of Composite Materials 52, no. 24 (2018): 3277–88. http://dx.doi.org/10.1177/0021998318764275.

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Effect of degree of cure on irreversible (viscoplastic) shear strain development in layers of glass fibre/ epoxy resin (LY5052 epoxy resin) [+45 °/−45 °]s laminate is studied performing a sequence of constant stress creep and viscoelastic strain recovery tests. For fixed values of degree of cure in range from 79.7% to 100%, the viscoplastic strains were measured as dependent on time and stress and Zapa's integral representation was used to characterize the observed behaviour. It is shown that at all degrees of cure the viscoplastic behaviour can be described by Zapa's model with parameters dep

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16

Yang, Miao, Liyun Xing, Xiaobo Liu, Yuqi Dong, and Jiliang Jin. "Dynamic corrosion mechanical properties of magnesium alloys with Erbium in the chloride ions environment." MATEC Web of Conferences 355 (2022): 01006. http://dx.doi.org/10.1051/matecconf/202235501006.

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The X-ray diffraction (XRD), scanning electron microscope (SEM), weight loss corrosion rate, corrosion residual strength (CRS), and slow strain rate tensile (SSRT) methods were used to study the effects of the addition of rare earth Erbium (Er) on the dynamic corrosion mechanical properties of the AM50 magnesium alloy. The results show that after Er was added, a new phase of Al3Er appeared and the microstructure was refined. The corrosion resistance of rare earth Er addition to the alloy was 0.5% > 1.5% > 1.0% > 0. Furthermore, the corrosion rates decreased in 432 h. The CRS results w

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17

Patham, Bhaskar, and Xiaosong Huang. "Multiscale Modeling of Residual Stress Development in Continuous Fiber-Reinforced Unidirectional Thick Thermoset Composites." Journal of Composites 2014 (March 24, 2014): 1–17. http://dx.doi.org/10.1155/2014/172560.

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The primary objective of this research is to develop a multiscale simulation framework to arrive at more realistic estimates of cure-induced residual stresses in the vicinity of the fiber-matrix interface in thick thermoset composites. The methodology involves simulations at the part level—employing homogenized rendering of the composite using micromechanics approach—within a finite element framework to obtain part-level temperature and degree-of-cure gradients and strains, and imposition of this information as boundary conditions at the mesoscale simulations, employing microstructural represe

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18

Li, Xue Qin, Zi Long Zhang, and Xiao Su Yi. "Cure-Induced Strain Development in an RTM Epoxy Resin as Monitored by Fiber Bragg Grating Sensors." Advanced Materials Research 694-697 (May 2013): 947–51. http://dx.doi.org/10.4028/www.scientific.net/amr.694-697.947.

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Optimizing the curing temperature to reducing the process costs may influence the properties of the material and bring quality assurance aspects. To solving the problem, real-time strain monitoring of the curing process has become more and more important and urgent. Fiber Bragg grating sensors were successfully used in this work to monitoring the residual strain building-up and the gelling phenomena of an RTM epoxy resin. The results shows chemical shrinkage strain during isothermal curing is bigger for higher curing temperature, but the average linear shrinkage ratio during cooling is smaller

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19

Li, Zhao, Wei Ke, Mingyao Liu, and Yang Zhou. "Reduction of Thermal Residual Strain in a Metal-CFRP-Metal Hybrid Tube Using an Axial Preload Tool Monitored through Optical Fiber Sensors." Polymers 14, no. 20 (2022): 4368. http://dx.doi.org/10.3390/polym14204368.

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Thermal residual strains/stresses cause several defects in hybrid structures and various studies have reported the reduction of residual strain. This paper describes a method for reducing thermal residual strains/stresses in metal-CFRP-metal hybrid tubes (MCMHT). The proposed axial preload tool provides two ways to reduce the thermal residual strains/stresses during the co-cure bonding process: pre-compressing of the metal layers and pre-stretching of the unidirectional carbon fiber reinforced polymer (CFRP) layers. An online measurement technique with embedded optical fiber Bragg grating (FBG

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20

Bondarchuk, Darya, and Boris Fedulov. "PROCESS MODELING OF CARBON-EPOXY COMPOSITES: RESIDUAL STRESS DEVELOPMENT DURING CURE AND ANALYSIS OF FREE EDGE EFFECTS." Aviation 23, no. 1 (2019): 15–22. http://dx.doi.org/10.3846/aviation.2019.9745.

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Last decades, increased attention is paid to the deep understanding of the process induced residual stresses (locked-in) and their effect on shape distortion and fracture. Residual stresses evaluation is particularly important in multilayered composites with anisotropic thermo-mechanical properties, where the ply orientations and stacking sequences highly influence the appearing of manufacturing stresses. In the present study, the effect of free edge on residual stresses inherited during manufacturing of thermoset multilayered composites was investigated. In order to understand the stress-stra

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21

Wiedemann, Johannes, Jan-Uwe R. Schmidt, and Christian Hühne. "Applicability of Asymmetric Specimens for Residual Stress Evaluation in Fiber Metal Laminates." Journal of Composites Science 6, no. 11 (2022): 329. http://dx.doi.org/10.3390/jcs6110329.

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Residual stresses in fiber metal laminates (FML) inevitably develop during the manufacturing process. The main contributor to these stresses is the difference in the coefficients of thermal expansion (CTE) between fibers and metal in combination with high process temperatures. To quantify these stresses, the use of specimens with an asymmetric layup is an easily adaptable method. The curvature that develops after the manufacturing of flat laminates with an asymmetrical layer stack is a measure of the level of residual stresses evolving during cure. However, the accuracy of the curvature evalua

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22

Sicot, Olivier, X. L. Gong, Xiao Jing Gong, Abel Cherouat, and Jian Lu. "Dependence Between Aging Treatments and Residual Stresses on Composite Laminate." Materials Science Forum 524-525 (September 2006): 813–17. http://dx.doi.org/10.4028/www.scientific.net/msf.524-525.813.

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The objective of this paper is to study the influence of residual stresses due to fabrication conditions on the thermomechanical behavior of carbon/epoxy laminate structures (cross ply). These studied laminates have undergone various cycles of thermal aging. The addition of a post-cure cycle after the end of the initial cycle makes it possible to reduce the residual stresses level. The incremental hole-drilling method is used to measure the residual strain in the laminates. These measured strains and the numerical calibration coefficients obtained by the finite element method allow to calculat

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23

Cui, Zhanxin, Haiyang Li, Zhibin Shen, and Huiru Cui. "Analysis of Load Optimization in Solid Rocket Motor Propellant Grain with Pressure Cure." International Journal of Aerospace Engineering 2021 (September 27, 2021): 1–11. http://dx.doi.org/10.1155/2021/5026878.

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At present, the casting of large-size motors often adopts pressure cure. This technology can effectively reduce the risk of damage to the structural integrity of the grain in the case-bonded casting solid rocket motor. In this paper, ABAQUS is used to establish a finite element model of star-shaped grains. The whole process of pressure cure was simulated and modeled, and the Python script was redeveloped. The Evol evolutionary algorithm was used in ISIGHT to optimize the load parameters such as pressure value, attenuation coefficient of the relief curve, and the attenuation coefficient of the

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24

Baran, Ismet, Jesper Hattel, and Remko Akkerman. "The Effect of Mandrel Configuration on the Warpage in Pultrusion of Rectangular Hollow Profiles." Key Engineering Materials 611-612 (May 2014): 250–56. http://dx.doi.org/10.4028/www.scientific.net/kem.611-612.250.

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Thermo-mechanical process simulation of an industrially pultruded rectangular hollow profile is presented. Glass/polyester is used for the continuous filament mat (CFM) and the uni-directional (UD) layers. The process induced residual distortions together with the temperature and degree of cure are predicted using a three dimensional (3D) thermo-chemical model sequentially coupled with a 2D quasi-static generalized plane strain mechanical model. The predicted deformation pattern at the end of the process is found to agree quite well with the one observed for the real pultruded parts in a comme

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25

Bezerra, Fernando Schemelzer de Moraes, Paulo Marcos Zech Coelho, and Carlos Alberto Pereira Tavares. "Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease." Revista do Instituto de Medicina Tropical de São Paulo 35, no. 4 (1993): 337–44. http://dx.doi.org/10.1590/s0036-46651993000400006.

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Aiming at demonstrating a decrease of acquired immunity after chemotherapeutic cure, a group of mice was infected with 25 Schistosoma mansoni cercariae (LE strain). A part of these animals was treated with 400 mg/kg oxamniquine, at 120 days after infection. Challenge infections were carried out at 45, 90 and 170-day-intervals after treatment (185, 210 and 290 days after primoinfection, respectively). Recovery of worms at 20 days after reinfections showed that a residual immunity remains up to 90 days after treatment, and disappears at 170 days after cure. Using the ELISA method, it was possibl

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Baran, Ismet, Cem C. Tutum, and Jesper Henri Hattel. "The Internal Stress Evaluation of Pultruded Blades for a Darrieus Wind Turbine." Key Engineering Materials 554-557 (June 2013): 2127–37. http://dx.doi.org/10.4028/www.scientific.net/kem.554-557.2127.

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This paper investigates the integrated modeling of a pultruded NACA0018 blade profile which is a part of the FP7 EU project DeepWind. The pultrusion process simulation is combined with the preliminary subsequent in-service load scenario. In particular, the process induced residual stresses and distortions are predicted by using a new approach combining a 3D Eulerian thermo-chemical analysis, in which the temperature and the cure degree distributions are obtained, and a 2D quasi-static plane strain mechanical analysis. The post-die region where convective cooling prevails is also included in th

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27

Li, Zhao, Mingyao Liu, Jintao Wang, and Wei Ke. "Residual Strain Monitoring and Dynamic Characteristics of Hybrid Hollow Square Tube with Metal–FRP–Metal Sandwich Walls." International Journal of Polymer Science 2022 (October 28, 2022): 1–12. http://dx.doi.org/10.1155/2022/9254833.

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In order to design and fabricate a novel hollow square tube (HST) for ram structure in machine tools, the hybrid HST with sandwich walls based on steel skins and unidirectional carbon fiber-reinforced polymer (CFRP) composite core is proposed. A detailed co-cured fabrication method with embedded fiber Bragg grating (FBG) sensors for residual strains/stresses determination in a hybrid metal–composite structure is presented. Results reveal that the hybrid HST has undergone complex residual strain history, and the strain rate is about 10 times the cooling rate. The tensile strains in the dwell st

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28

Wachtarczyk, Karol, Marcel Bender, Ewald Fauster, Ralf Schledjewski, Paweł Gąsior, and Jerzy Kaleta. "Gel Point Determination in Resin Transfer Molding Process with Fiber Bragg Grating Inscribed in Side-Hole Elliptical Core Optical Fiber." Materials 15, no. 18 (2022): 6497. http://dx.doi.org/10.3390/ma15186497.

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Material as well as process variations in the composites industry are reasons to develop methods for in-line monitoring, which would increase reproducibility of the manufacturing process and the final composite products. Fiber Bragg Gratings (FBGs) have shown to be useful for monitoring liquid-composite molding processes, e.g., in terms of online gel point detection. Existing works however, focus on in-plane strain measurements while out-of-plane residual strain prevails. In order to measure out-of-plane strain, FBG inscribed in highly birefringent fiber (HB FBG) can be used. The purpose of th

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29

Ohlemacher, Crittenden J., and Gary R. Hamed. "Aging with Applied Strain of A Black-Filled Natural Rubber Vulcanizate. Part I: Network Changes." Rubber Chemistry and Technology 81, no. 4 (2008): 650–70. http://dx.doi.org/10.5254/1.3548225.

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Abstract Black-filled natural rubber, with an inefficient sulfur cure, was aged at 90 °C and 110 °C under nitrogen, with and without applied strain. Samples aged under strain became “double networks” and retained a residual extension ratio. The crosslink density of samples passed through a maximum with increasing severity of aging. Presumably this arises because the thermally labile, polysulfidic crosslinks break, and new crosslinks of lower rank form, resulting in increased crosslink density; but, when aged at 110 °C, this is offset by chain scission and other main-chain modifications. For do

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30

Hamed, G. R., and M. Y. Huang. "Tensile and Tear Behavior of Anisotropic Double Networks of a Black-Filled Natural Rubber Vulcanizate." Rubber Chemistry and Technology 71, no. 5 (1998): 846–60. http://dx.doi.org/10.5254/1.3538513.

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Abstract Double networks of a black-filled natural rubber composition have been prepared by partially curing a sheet, stretching it, and then completing cure. Upon release, a double network retracts to a residual extension ratio, αr. Samples cut perpendicular to the stretch direction have stress—strain responses like the isotropic single network, while parallel samples have enhanced stiffness and tensile strength, and reduced extensibility. Tensile strength is rather weakly dependent on αr. Tear strengths of the double networks, determined using edge-cut strip specimens, exceed that of the sin

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31

Wündisch, Thomas, Christian Thiede, Andrea Morgner, et al. "Long-Term Follow-Up of Gastric MALT Lymphoma After Helicobacter Pylori Eradication." Journal of Clinical Oncology 23, no. 31 (2005): 8018–24. http://dx.doi.org/10.1200/jco.2005.02.3903.

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Purpose Cure of infection induces remissions in most patients with early stage Helicobacter pylori- (Hp) positive gastric MALT (mucosa-associated lymphoid tissue) lymphoma (GML). We tracked the long-term stability of remissions in this prospective, multicenter trial. Patients and Methods In 120 patients with stage I1E disease, we performed sequential endoscopic-bioptic follow-up after Hp eradication and polymerase chain reaction of the rearranged immunoglobulin heavy chain gene. The status of t(11;18) was assessed in 65 patients. Results Median follow-up was 75 months (range, one to 116). Five

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Montillo, Marco, Alessandra Tedeschi, Valentina Rossi, et al. "Alemtuzumab as Consolidation after a Response to Fludarabine Is Effective To Purge Residual Disease in Patients with Chronic Lymphocytic Leukemia." Blood 104, no. 11 (2004): 479. http://dx.doi.org/10.1182/blood.v104.11.479.479.

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Abstract Although an increasing number of patients with chronic lymphocytic leukemia (CLL) may achieve complete remission (CR) relapse is almost inevitable, due to re-emergence of the malignant clone. The eradication of minimal residual disease (MRD) is associated with improved remission durability and has great potential in offering the possibility of cure in many lymphoid malignancies. The monoclonal antibody alemtuzumab is the foundation of many eradication-based treatment approaches because of its ability to achieve clinical remissions and to successfully purge MRD. We investigate the use

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Deng, Biping, Alex Hongsheng Chang, Junfang Yang, et al. "Safety and Efficacy of Low Dose CD19 Targeted Chimeric Antigen Receptor T (CAR-T) Cell Immunotherapy in 47 Cases with Relapsed Refractory B-Cell Acute Lymphoblastic Leukemia (B-ALL)." Blood 128, no. 22 (2016): 649. http://dx.doi.org/10.1182/blood.v128.22.649.649.

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Abstract Abstract Introduction: Patients (pts) with relapsed refractory B-ALL are mostly incurable by chemotherapy. The disease free survival (DFS) is low even treatment with allogeneic hematopoietic stem cell transplantation (allo-HSCT). We explored treatment of 47 cases of relapsed refractory B-ALL with low dose CD19 CAR-T cells and assessed the clinical safety and efficacy. Patients and Methods: (6-8)X107 pts' peripheral blood mononuclear cells(PBMCs) were activated with CD3 and CD28 antibodies for 24h, then transduced with the lentivirus encoding anti-CD19-CD3zeta-4-1BB CAR (Image1/Picture

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Ernst, L. J., C. van ’t Hof, D. G. Yang, et al. "Mechanical Modeling and Characterization of the Curing Process of Underfill Materials." Journal of Electronic Packaging 124, no. 2 (2002): 97–105. http://dx.doi.org/10.1115/1.1459471.

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Thermo-setting polymers are widely used as underfill materials to improve the reliability of electronic packages. In the design phase, the influence of underfill applications on reliability is often judged through thermal and mechanical simulations, under assumed operating conditions. Because of lacking insight into the mechanical processes due to polymer curing, the impact of processing induced residual stress fields is often neglected. To investigate the evolution of stress and strain fields during the curing process it is important to assume a more appropriate starting point for subsequent

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35

Baran, Ismet, Johnny Jakobsen, Jens H. Andreasen, and Remko Akkerman. "Investigation of the Residual Stress State in an Epoxy Based Specimen." Key Engineering Materials 651-653 (July 2015): 375–80. http://dx.doi.org/10.4028/www.scientific.net/kem.651-653.375.

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Process induced residual stresses may play an important role under service loading conditions for fiber reinforced composite. They may initiate premature cracks and alter the internal stress level. Therefore, the developed numerical models have to be validated with the experimental observations. In the present work, the formation of the residual stresses/strains are captured from experimental measurements and numerical models. An epoxy/steel based sample configuration is considered which creates an in-plane biaxial stress state during curing of the resin. A hole drilling process with a diamete

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Soares, CJ, AA Bicalho, C. Verissimo, PBF Soares, D. Tantbirojn, and A. Versluis. "Delayed Photo-activation Effects on Mechanical Properties of Dual Cured Resin Cements and Finite Element Analysis of Shrinkage Stresses in Teeth Restored With Ceramic Inlays." Operative Dentistry 41, no. 5 (2016): 491–500. http://dx.doi.org/10.2341/15-090-l.

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SUMMARY Objective: The aim of this study was to investigate the effect of delayed photo-activation on elastic modulus, Knoop hardness, and post-gel shrinkage of dual cure resin cements and how this affects residual shrinkage stresses in posterior teeth restored with ceramic inlays. Methods and Materials: Four self-adhesive (RelyX Unicem, 3M ESPE; GCem, GC; MonoCem, Shofu; and seT, SDI) and two conventional (RelyX ARC, 3M ESPE; and AllCem, FGM) dual cure resin cements for cementing posterior ceramic inlays were tested. Strain gauge and indentation tests were used to measure the post-gel shrinka

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Rocha, Helena, Christopher Semprimoschnig, and João P. Nunes. "Small-diameter optical fibre sensor embedment for ambient temperature cure monitoring and residual strain evaluation of CFRP composite laminates produced by vacuum-assisted resin infusion." CEAS Space Journal 13, no. 3 (2021): 353–67. http://dx.doi.org/10.1007/s12567-021-00357-5.

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Tinkloh, Steffen, Tao Wu, Thomas Tröster, and Thomas Niendorf. "The Effect of Fiber Waviness on the Residual Stress State and Its Prediction by the Hole Drilling Method in Fiber Metal Laminates: A Global-Local Finite Element Analysis." Metals 11, no. 1 (2021): 156. http://dx.doi.org/10.3390/met11010156.

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In this paper, fiber waviness, as one of the most frequently occurring defects in fiber reinforced composites, is numerically investigated with regard to the formation of residual stresses in fiber metal laminates. Furthermore, the prediction of the residual stress state in the thickness direction by means of the simulated hole drilling method is studied. To this regard, a global-local finite element analysis based on the submodel technique is presented. The submodel technique essentially consists of two governing steps: In the first step, a global model is first utilized to calculate and anal

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Бондарчук, Дарья Александровна, Борис Никитович Федулов, and Евгений Викторович Ломакин. "Analysis of the influence of residual stresses on possible defects formed during production of carbon-epoxy composites." Вестник Чувашского государственного педагогического университета им. И.Я. Яковлева. Серия: Механика предельного состояния, no. 2(44) (December 14, 2020): 59–68. http://dx.doi.org/10.37972/chgpu.2020.44.2.006.

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В настоящей работе изучено влияние наличия остаточных напряжений в образце углерод-эпоксидного композита, сформировавшихся в процессе его производства, на такие возможные дефекты как межслоевое расслоение. Исследование посвящено анализу НДС в регулярных образцах вблизи зоны дефекта в течение цикла отверждения, а также при образовании свободного края в материале после разреза в зависимости от длины трещины. Для моделирования процесса отверждения решалась связанная тепловая и прочностная задача в условиях плоской деформации. Для описания поведения композитного материала в процессе производства,

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Grupp, Stephan, Zhen-Huan Hu, Yiyun Zhang, et al. "Tisagenlecleucel Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Children and Young Adults with Acute Lymphoblastic Leukemia (ALL): Real World Experience from the Center for International Blood and Marrow Transplant Research (CIBMTR) and Cellular Therapy (CT) Registry." Blood 134, Supplement_1 (2019): 2619. http://dx.doi.org/10.1182/blood-2019-129279.

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Background Tisagenlecleucel is a CD19-directed genetically modified autologous T-cell immunotherapy approved for the treatment of patients up to 25 years of age with B-cell ALL that is refractory or in second or later relapse. In the pivotal ELIANA trial, 79 patients were treated with tisagenlecleucel. The best overall response rate (CR/CRi) was 82%; 98% of patients who achieved CR/CRi were also negative for minimal residual disease (MRD). With a median follow-up of 24 months, the median duration of remission was not reached. Grade 3 or higher cytokine release syndrome (CRS) by UPenn criteria

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Chong, Elise A., James N. Gerson, Daniel J. Landsburg, et al. "Outcomes in Aggressive B-Cell Non-Hodgkin Lymphomas with Anti-CD19 CAR T-Cell (CTL019) Products Not Meeting Commercial Release Specifications." Blood 134, Supplement_1 (2019): 594. http://dx.doi.org/10.1182/blood-2019-131078.

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Introduction: Tisagenlecleucel (CTL019, tisa-cel) was recently approved for treatment of relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL), high grade B cell lymphoma (r/r HGBCL), and transformed follicular lymphoma (r/r tFL) after second line therapy. Prior to tisa-cel release for commercial use in the United States (US), the final manufactured, patient-specific product must meet specific Lot Release Specifications including requirements that the product's dose contains 0.6 to 6.0 x 108 CAR-positive viable T cells and total cell viability is at least 80%. CAR T cell products that

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Garfall, Alfred L., Adam D. Cohen, Simon F. Lacey, et al. "Combination Anti-Bcma and Anti-CD19 CAR T Cells As Consolidation of Response to Prior Therapy in Multiple Myeloma." Blood 134, Supplement_1 (2019): 1863. http://dx.doi.org/10.1182/blood-2019-131515.

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BACKGROUND: Anti-BCMA CAR T cells are effective in relapsed/refractory multiple myeloma (RRMM), but most patients eventually progress. Extensive prior therapy and high disease burden in RRMM pts may compromise CAR T cell safety, feasibility, and efficacy, and rare BCMA-neg/CD19+ MM cells with enhanced clonogenic potential may mediate relapse after anti-BCMA CARs. We therefore initiated a trial of anti-BCMA CAR T cells (CART-BCMA) as consolidation of response to prior MM therapy, including high-risk (HR) pts responding to first-line therapy, and combined CART-BCMA with anti-CD19 CAR T cells (CT

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Minson, Adrian, Nada Hamad, Jason P. Butler, et al. "A Phase II, Open-Label, Single Arm Trial to Assess the Efficacy and Safety of the Combination of Tisagenlecleucel and Ibrutinib in Mantle Cell Lymphoma (TARMAC)." Blood 136, Supplement 1 (2020): 34–35. http://dx.doi.org/10.1182/blood-2020-138946.

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Background Mantle cell lymphoma (MCL) is a clinically and pathogenetically distinct B-cell non-Hodgkin lymphoma that presents at a median age of 65 years and typically at an advanced stage. High dose chemotherapy and stem cell transplantation can achieve durable responses, but disease eventually relapses in most patients. Allogeneic transplantation can achieve a cure in some but is only suitable for a minority of younger, fitter patients who achieve remission to salvage but carries risks of GVHD. Bruton tyrosine kinase inhibitors (BTKi) are active in relapsed MCL but the median PFS is generall

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Hummel, Horst D., Gaby Kuntz, Takafumi Nakamura, et al. "Fully Retargeted Oncolytic Measles Virus for Multiple Myeloma Therapy." Blood 108, no. 11 (2006): 5474. http://dx.doi.org/10.1182/blood.v108.11.5474.5474.

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Abstract Multiple Myeloma (MM) is a disseminated plasma cell malignancy with approximately 14,600 new cases diagnosed in the USA annually. Despite recent progress in current therapeutical options the median survival is 3 to 5 years and cure is extremely rare. Therefore the evaluation of new treatment modalities for MM is highly warranted. An attractive approach to treat Myeloma with a minimum of undesired side effects is the use of a tumour antigen specific for MM cells. Wue-1, a monoclonal antibody binds very selectively normal and malignant plasma cells (50 of 51 MM samples, 14 of 15 immunoc

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Mahto, Brindaban, Sagar Kubher, and Suhasini Gururaja. "Characterization of cure residual strain development and associated structural distortion in carbon fiber polymer matrix composites." Journal of Composite Materials, June 28, 2022, 002199832211098. http://dx.doi.org/10.1177/00219983221109865.

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A comprehensive experimental methodology has been developed to measure the in situ cure residual strain (CRS) generation in carbon fiber reinforced polymer (CFRP) laminates using embedded fiber Bragg grating (FBG) sensors. In order to delineate the effect of anisotropy, heterogeneity, laminate thickness and geometry, in situ CRS is measured in pristine epoxy, uni-directional (UD)-CFRPs, multi-directional (MD)-CFRPs and L-shaped MD-CFRP laminates. In this study, emphasis is laid on quantifying the variation in CRS magnitudes as a function of laminates lay-up sequence and thickness. Calibration

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Wang, Wei, Huaiju Liu, Caichao Zhu, Philippe Bocher, Heli Liu, and Zhangdong Sun. "Evaluation of Rolling Contact Fatigue of a Carburized Wind Turbine Gear Considering the Residual Stress and Hardness Gradient." Journal of Tribology 140, no. 6 (2018). http://dx.doi.org/10.1115/1.4040052.

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Carburized gears are applied extensively in large-scale heavy duty machines such as wind turbines. The carburizing and quenching processes not only introduce variations of hardness from the case to the core but also generate a residual stress distribution, both of which affect the rolling contact fatigue (RCF) during repeated gear meshing. The influence of residual stress distribution on the RCF risk of a carburized wind turbine gear is investigated in the present work. The concept of RCF failure risk is defined by combining the local material strength and the multi-axial stress condition resu

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Sghaier, Rabiaa M., Fouad Benhnini, Fatma Z. Guerfali, et al. "Healed Lesions of Human Cutaneous Leishmaniasis Caused By Leishmania major Do Not Shelter Persistent Residual Parasites." Frontiers in Cellular and Infection Microbiology 12 (July 27, 2022). http://dx.doi.org/10.3389/fcimb.2022.839216.

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In human cutaneous leishmaniasis (HCL) caused by Leishmania (L.) major, the cutaneous lesions heal spontaneously and induce a Th1-type immunity that confers solid protection against reinfection. The same holds true for the experimental leishmaniasis induced by L. major in C57BL/6 mice where residual parasites persist after spontaneous clinical cure and induce sustainable memory immune responses and resistance to reinfection. Whether residual parasites also persist in scars of cured HCL caused by L. major is still unknown. Cutaneous scars from 53 volunteers with healed HCL caused by L. major we

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Cameron, Christopher, Dženan Hozić, Fredrik Stig, and Sjoerd van der Veen. "A method for optimization against cure-induced distortion in composite parts." Structural and Multidisciplinary Optimization 66, no. 3 (2023). http://dx.doi.org/10.1007/s00158-023-03504-0.

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AbstractThis paper describes a novel method developed for the optimization of composite components against distortion caused by cure-induced residual stresses. A novel ply stack alteration algorithm is described, which is coupled to a parametrized CAD/FE model used for optimization. Elastic strain energy in 1D spring elements, used to constrain the structure during analysis, serves as an objective function incorporating aspects of global/local part stiffness in predicted distortion. Design variables such as the number and stacking sequence of plies, and geometric parameters of the part are use

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Greksák, R. "Characteristics and Treatment of Hairy Cell Leukaemia." Acta Facultatis Pharmaceuticae Universitatis Comenianae 61, no. 1 (2014). http://dx.doi.org/10.2478/afpuc-2014-0002.

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AbstractHairy cell leukaemia (HCL) is a rare chronic indolent lymphoproliferative disease of B-lymphocytes. It always infiltrates the spleen, bone marrow or other organs and is also present in the peripheral blood in more than 95% of cases. The disease takes its name from its characteristic wrinkled surface with hair-like projections. The prognosis of this infaust diagnosis has dramatically changed since the 1980s through more precise diagnosis and efective treatment with purine analogues (1984, 2-deoxycoformy-cine (2-dCF); 1990, 2-chlorodeoxyadenosine (2-CdA)). In our group of 38 patients, we

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