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Dissertations / Theses on the topic 'Cutaneous tumor'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Lu, Fuqu. "Role of tumor suppressor p33ING2 inhuman cutaneous melanoma." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31855.

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P33JNG2 was cloned through a homology search with p33INGlb, the founding member of ING family proteins in 1998. There have been several studies indicating that p331NG2 is a tumor suppressor candidate since it is involved in the regulation of transcription, apoptosis and senescence. People in our lab already revealed that p33ING2 plays an essential role in cellular stress response against UV irradiation (UVR) either by enhancing nucleotide excision repair (NER) or promoting apoptosis in melanoma cell line. So far, reduced ING family proteins have been reported in different tumor types inc
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2

Li, Jun. "Role of tumor suppressor ing4 in human cutaneous melanoma pathogenesis and progression." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/30234.

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ING4 was identified as a tumor suppressor in 2003 and shown to diminish colony-forming efficiency, induce p53-dependent apoptosis, and arrest cell cycle at G2/M phase. To investigate the role of ING4 in human cutaneous melanoma, we examined ING4 expression using tissue microarray and found that ING4 expression was significantly decreased in malignant melanoma compared with dysplastic nevi and reduced ING4 expression was correlated with melanoma thickness, ulceration and poor 5-year survival of melanoma patients. Multivariate analysis revealed that ING4 expression is an independent prognostic m
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3

Shakya, Sajina. "ROLE OF TUMOR NECROSIS FACTOR-STIMULATED GENE-6 IN CUTANEOUS WOUND HEALING AND INFLAMMATION." Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu1572915446243341.

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4

Lamberti, Arianna. "PRIMARY MELANOMA OF THE SKIN AND CUTANEOUS MELANOMA METASTASES: COMPARATIVE STUDY OF TUMOR MICROENVIRONMENT." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1073036.

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Melanoma incidence is steadily increasing in the Western world. Surgery largely controls melanomas in early stages, whereas advanced disease is still a therapy challenge. Cutaneous melanoma comprises different subgroups according to epidemiology, biological behavior, prognostic features, and molecular profiles. The tumor microenvironment rich in lymphocytes (TILs brisk) represents a complex signaling network with a controversial prognostic role. Notwithstanding the continuous crosstalk of melanoma cells with dendritic cells and T-cells in both peripheral blood and lymph nodes, the immune ed
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5

Gillgren, Peter. "Body site of cutaneous malignant melanoma : primary tumor location in relation to phenotypic and prognostic factors /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-339-2.

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6

Martins, Claudia Maria de Oliveira 1961. "Expression of the metastasis suppressor gene KISS1 in uveal and cutaneous melanoma." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116098.

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Uveal Melanoma (UM) is the most common malignant intra-ocular tumor in adults. Forty-five percent of UM patients develop metastasis within fifteen years of the initial diagnosis. Cutaneous Melanoma (CM) is a highly metastatic cancer that accounts for the majority of skin cancer deaths. Current treatments are not especially effective for the metastatic phase of the disease. Therefore, the identification of new molecular targets that can be exploited in the clinic are needed.<br>KISS1 is a putative human metastasis suppressor gene. The purpose of this study was to investigate the expression of K
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7

Esmailzadeh, Sharmin. "The role of BIN1 in the regulation of cell proliferation, apoptosis and tumor formation in cutaneous T-cell lymphoma." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50568.

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Cutaneous T-cell lymphomas (CTCLs) represent a group of lymphoproliferative disorders characterized by homing of malignant T-cells to the skin’s surface. There are two main types of CTCL: Mycosis Fungoides (MF) and Sezary Syndrome (SS). We have demonstrated that expression of the Abelson helper integration site-1 (AHI-1) oncogene is significantly increased in CD4⁺CD7- cells from SS patients. Bridging integrator 1 (BIN1) has been identified by microarray analysis of CTCL cells as a candidate gene involved in AHI-1-mediated lymphomagenesis. Interestingly, BIN1expression is significantly redu
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8

Pak, Fatemeh. "Development of AIDS associated and endemic Kaposi sarcoma: HHV-8/KSHV viral load in cutaneous and oral tumor cells." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-878-9/.

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9

Vidale, Mariana Marras [UNESP]. "Avaliação da prliferação e apoptose com a utilização de arranjos em matriz de amostra tecidual (Tissue Microarray - TMA) em mastocitomas cutâneos caninos." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/89270.

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Made available in DSpace on 2014-06-11T19:23:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-12-20Bitstream added on 2014-06-13T20:11:39Z : No. of bitstreams: 1 vidale_mm_me_botfmvz.pdf: 990676 bytes, checksum: e0f154e998cb1f98077440b3e6f5df43 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Os mastócitos são células provenientes do precursor CD34 da medula óssea, o mastocitoma (MCT) pertence ao grupo das neoplasias de células redondas e possui etiologia desconhecida, é a neoplasia cutânea mais comum em cães, sem predileção por raça, sexo ou idade. Se
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10

Nardy, Vanessa Brandão. "Epidemiologia e distribuição dos loci de TNFs associados à leishmaniose tegumentar em uma comunidade rural do Sudoeste da Bahia, Brasil." reponame:Repositório Institucional da FIOCRUZ, 2009. https://www.arca.fiocruz.br/handle/icict/4319.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-09-04T17:22:14Z No. of bitstreams: 1 Vanessa Brandão Nardy Epidemiologia e distribuição dos loci....pdf: 968050 bytes, checksum: 2bf834f732f1945b7c707aa0ed94f21c (MD5)<br>Made available in DSpace on 2012-09-04T17:22:14Z (GMT). No. of bitstreams: 1 Vanessa Brandão Nardy Epidemiologia e distribuição dos loci....pdf: 968050 bytes, checksum: 2bf834f732f1945b7c707aa0ed94f21c (MD5) Previous issue date: 2009<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>A leishmaniose tegumentar (
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11

Vidale, Mariana Marras. "Avaliação da prliferação e apoptose com a utilização de arranjos em matriz de amostra tecidual (Tissue Microarray - TMA) em mastocitomas cutâneos caninos /." Botucatu : [s.n.], 2010. http://hdl.handle.net/11449/89270.

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Orientador: Renée Laufer Amorim<br>Banca: Noeme Sousa Rocha<br>Banca: Antonio Carlos Alessi<br>Resumo: Os mastócitos são células provenientes do precursor CD34 da medula óssea, o mastocitoma (MCT) pertence ao grupo das neoplasias de células redondas e possui etiologia desconhecida, é a neoplasia cutânea mais comum em cães, sem predileção por raça, sexo ou idade. Seu comportamento biológico é bastante agressivo e de alta frequência. A graduação histopatológia proposta Patnaik et al., (1984), é o critério mais utilizado para a graduação histopatológica da neoplasia sendo o grau 1 uma neoplasia b
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12

Sharav, Tumenjargal. "Tumor-spezifische T-Zellen und T-Zellepitope bei kutanen Lymphomen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2005. http://dx.doi.org/10.18452/15220.

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Ziel dieser Arbeit war die Identifizierung von Tumor-assozierten T-Zellepitopen (TATE) in kutanen T-Zelllymphomen (CTCL) und die Charakterisierung der Tumour-spezifischen zytotoxischen Immunabwehr. Zwei Tumor-spezifische T-Zellklone wurden aus den Tumor-infiltrierenden Lymphozyten (TIL) eines CTCL-Patienten etabliert. Die potentiellen natürlichen T-Zellepitope und Mimotope (synthetische Epitope ohne natürliche Korrelate aber mit meist hohen T-Zellaktivitäten) für diese Klone wurden mit einer kombinatorischen Peptidbibliothek identifiziert. Die Qualität und Quantität der T-Zellaktivitäten waren
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13

Bonin, Vermeulen Ophélie. "Mécanisme d’action de la stratégie d’immunothérapie locale TLR9L+aIL- 10Rα contre les carcinomes épidermoïdes cutanés". Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://theses.univ-cotedazur.fr/2021COAZ6018.

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Les carcinomes cutanés représentent 90% des cancers de la peau. Les stratégies actuelles de traitement, la chirurgie et la radiothérapie sont peu efficaces contre les formes invasives. La mise en place d’un traitement impliquant une réponse immunitaire à long terme permettrait de contrôler ces formes invasives et leurs récidives. L’équipe a ainsi développé une immunothérapie basée sur l’injection péri-tumorale d’un agoniste de TLR9 (ODN2395) avec un anticorps bloquant la signalisation à travers le récepteur à l’IL-10 (CD210). Cette stratégie thérapeutique induit la régression totale des tumeur
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14

Simonneau, Marie. "Implication de l'Oncostatine M dans la genèse et le développement des carcinomes épidermoïdes cutanés." Thesis, Poitiers, 2018. http://www.theses.fr/2018POIT1403/document.

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Le carcinome épidermoïde cutané (CEC) est l'un des cancers les plus fréquents et il est résistant aux traitements chimiothérapeutiques classiques. De nombreuses études montrent que selon leur phénotype les cellules du microenvironnement inflammatoire peuvent inhiber (cellules Th1/M1) ou favoriser (cellules Th2/M2) le développement tumoral. En fonction des cytokines présentes dans ce microenvironnement, il est possible de reprogrammer les cellules immunitaires et de les rendre moins permissives au développement tumoral. L’onconstatine M (OSM) est une cytokine aux effets pléiotropes, elle peut f
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15

Healy, Eugene. "Genetic changes in cutaneous melanoma." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389573.

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16

Baines, S. J. "Canine cutaneous histiocytoma : characterisation of a dendritic cell tumour." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596266.

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Canine cutaneous histiocytoma (CCH) is a common, benign tumour of dendritic cells (DCs). This tumour undergoes an early period of rapid growth over one to four weeks, followed by spontaneous regression, in most cases, over the next one to three months. Regression is associated with the influx of CD8+ T lymphocytes. The research in this thesis aimed to identify the state of differentiation of the neoplastic cells and to identify if they matched DC parameters on the basis of morphology, phenotype and function. Neoplastic dendritic cells isolated from excised tumours had a monocytoid appearance o
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17

Tura, Giorgia <1987&gt. "Molecular analysis of Papillomavirus-induced cutaneous tumors in equids." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10208/1/Tura_Giorgia_tesi.pdf.

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Papillomavirus associated tumors are well recognized entities in humans as well as in animals. Here is reviewed the current understanding of human papillomavirus (HPV) associated cancers to better understand the oncogenic mechanisms of Equine papillomavirus (EcPV) and Bovine Papillomavirus (BPV) in horses. In the first part of this study the interactions between Equine papillomavirus 2 (EcPV-2) and cell cycle proteins are discussed. EcPV-2 has been recognized as the cause of genital squamous cell carcinomas (SCCs) in horses, but the exact mechanism of carcinogenesis is not fully understood. T
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18

Sexauer, Desiree. "Autoantibodies as prognostic biomarkers for cutaneous melanoma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2022. https://ro.ecu.edu.au/theses/2557.

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Cutaneous melanoma is the most aggressive type of skin cancer that is responsible for more than 80% of skin cancer-related deaths. The incidence of cutaneous melanoma, especially thin ( < 1.0 mm) melanomas, continues to increase nationally and globally. Although thick ( ≥ 4.0 mm) melanomas are correlated with a worse prognosis, thin melanomas account for the majority of melanoma deaths due to the high volume of the disease. Therefore, there is currently an urgent need to identify melanoma-associated prognostic biomarkers for the effective monitoring of patients that are predicted to have an in
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19

Meyer, Anja Marina [Verfasser]. "Interleukin-2 Receptor Expression in Canine Cutaneous Mast Cell Tumors / Anja Marina Meyer." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1036872637/34.

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20

Flint, Melanie Sarah. "Induction and regulation of epidermal cytokines." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322116.

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21

Ouboussad, Lylia. "Identification of novel tumour suppressor genes involved in the development of cutaneous malignant melanoma." Thesis, Brunel University, 2009. http://bura.brunel.ac.uk/handle/2438/4393.

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Skin cancer is one of the most common forms of adult solid tumour. The incidence is increasing rapidly making skin cancer a major health problem in several countries. Cutaneous Malignant Melanoma (CMM) is the least common but the most life threatening type of skin cancers and is responsible for 90% of all skin malignancy associated deaths. The precise cellular and molecular etiology of malignant melanoma is quite complex and the molecular events directly related to melanoma progression are yet to be elucidated. However, recent advances in molecular biology have resulted in a clearer understand
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22

Elaldi, Roxane. "Carcinomes épidermoïdes cutanés : caractérisation du micro-environnement immunitaire tumoral et identification de biomarqueurs moléculaires pronostiques." Electronic Thesis or Diss., Université Côte d'Azur, 2023. https://intranet-theses.unice.fr/2023COAZ6054.

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Les carcinomes épidermoïdes cutanés (CEC) sont les deuxièmes tumeurs cutanées les plus fréquentes après les carcinomes basocellulaires. Elles sont majoritairement traitées par chirurgie et de bon pronostic. Mais certaines tumeurs à « haut risque », et particulièrement celles situées au niveau de la face et du cou, récidivent fréquemment dans les 2 ans après la chirurgie. Ces récidives, parfois inopérables, sont de mauvais pronostic et l'identification des patients atteints d'une tumeur à « haut risque » n'est pas consensuelle, ce qui constitue un problème majeur pour la prise en charge de ces
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23

Morrison, Jo Ann. "Identification and correlation of cytologic criteria to histologic grade in canine cutaneous mast cell tumors." [Ames, Iowa : Iowa State University], 2007.

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24

Lyth, Johan. "Clinical-epidemiological studies on cutaneous malignant melanoma : A register approach." Doctoral thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-113145.

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The incidence of cutaneous malignant melanoma (CMM) is steadily increasing. Most of the patients have thin CMM with a good prognosis and a 5-year survival of about 90%. The prognosis is highly related to tumour thickness and clinical stage at diagnosis. Effective systemic treatment for patients with metastatic disease has only recently been available. This thesis aims to increase knowledge of trends in tumour thickness, prognostic factors, socioeconomic differences and medical costs in patients with CMM. The population-based Swedish melanoma register is the main source of data in all papers in
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25

LIMA, Luiza Rayanna Amorim de. "Quimiluminescência utilizando lectinas conjugadas a éster de acridina na avaliação histoquímica de tumores cutâneos e da interação lectina-carboidrato." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/17482.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-07-20T15:04:22Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Luiza Lima_Tese de Doutorado_2015.pdf: 5654099 bytes, checksum: da2a7cb303b6562f1bc8af5fc0c76f13 (MD5)<br>Made available in DSpace on 2016-07-20T15:04:22Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Luiza Lima_Tese de Doutorado_2015.pdf: 5654099 bytes, checksum: da2a7cb303b6562f1bc8af5fc0c76f13 (MD5) Previous issue date: 2015-10-29<br>CAPEs<br>
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26

Agnarsdóttir, Margrét. "Biomarker Discovery in Cutaneous Malignant Melanoma : A Study Based on Tissue Microarrays and Immunohistochemistry." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-146436.

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The incidence of cutaneous malignant melanoma has increased dramatically in Caucasians the last few decades, an increase that is partly explained by altered sun exposure habits. For the individual patient, with a localized disease, the tumor thickness of the excised lesion is the most important prognostic factor. However, there is a need to identify characteristics that can place patients in certain risk groups. In this study, the protein expression of multiple proteins in malignant melanoma tumors was studied, with the aim of identifying potential new candidate biomarkers. Representative samp
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27

Hafsi, Hind. "N-terminal isoforms of the p53 tumour suppressor protein : effects on p53 transcriptional activity and expression in cutaneous melanoma." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00995000.

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The p53 tumour suppressor protein has a highly complex pattern of regulation at transcriptional and posttranslationallevels. The discovery of p53 isoforms has added another layer of complexity to the mechanisms thatregulate p53 functions. Indeed, p53 is expressed as 12 isoforms that differ in their N- and C-terminus due toalternative splicing, promoter or codon initiation usage. So far, there is limited understanding of the patterns ofexpression and of the functions of each of these isoforms.In this Thesis, we have focused on the two major p53 N-terminal isoforms, Δ40p53 and Δ133p53. We havean
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28

Zaenker, Pauline. "The identification and validation of a diagnostic signature of tumour-associated autoantibodies for the early diagnosis of cutaneous melanoma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2018. https://ro.ecu.edu.au/theses/2129.

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Background Cutaneous melanoma is an aggressive cancer with a high propensity to metastasise. Melanomarelated fatalities are however preventable through early detection and complete surgical excision of the primary tumour. Current screening methods for melanoma are effective but limited to the visual examination of the skin, potentially leading to a delay in diagnosis of less obvious lesions. Circulating biomarkers have been proposed to aid with early melanoma diagnosis and are easily accessible by routine blood collection. However, despite intensive scientific efforts, there are currently no b
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29

Verykiou, Stamatina. "Cross talk between CD271 expressing tumour subpopulations and autophagy in the drug resistance, invasion and survival of cutaneous metastatic melanoma." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3932.

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Cutaneous malignant melanoma remains an increasing world health problem. Although targeted therapy to hyper-activated MAPK signalling has significantly increased survival for patients with BRAF/NRAS mutant melanomas, the development of acquired resistance is inevitable and associated with the emergence of chemo-resistant subpopulations expressing the neurotrophin receptor CD271. The relationship between drug-induced CD271 expressing subpopulations and autophagy however, remains undefined. The central aim of the present study was to define the relationship between CD271 (both constitutive and d
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Brown, Victoria Lissa. "The role of p16'I'N'K'4'a and p14'A'R'F tumour suppressor genes in the pathogenesis of cutaneous squamous cell carcinoma." Thesis, Queen Mary, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423542.

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LAI, SIMONE. "Fattori prognostici nel melanoma cutaneo e nel tumore mammario associati a caratteristiche molecolari simil-staminali." Doctoral thesis, Università degli Studi di Cagliari, 2013. http://hdl.handle.net/11584/266210.

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Nestin (a neuronal stem cell/progenitor cell marker of central nervous system development), vimentin (which is ubiquitously expressed in mesenchymal cells), and the glucocorticoid receptor (GR, which is involved in the immune response, cell proliferation, and apoptosis) have been shown to interact in embryonic and undifferentiated tissues in modulating cell proliferation. In recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. The aim of this study was to analyse nestin, vimentin and GR expression in tumour ti
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Katerinaki, Efthymia. "The pro-invasive effects of tumour necrosis factor-alpha (TNF-α) on human cutaneous melanoma and the inhibitory actions of non-steroidal anti-inflammatory drugs." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412782.

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Lyth, Johan, J. Hansson, C. Ingvar, et al. "Prognostic subclassifications of T1 cutaneous melanomas based on ulceration, tumour thickness and Clark’s level of invasion : results of a population-based study from the Swedish Melanoma Register." Linköpings universitet, Onkologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-92611.

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Background  Survival and prognostic factors for thin melanomas have been studied relatively little in population-based settings. This patient group accounts for the majority of melanomas diagnosed in western countries today, and better prognostic information is needed. Objectives  The aim of this study was to use established prognostic factors such as ulceration, tumour thickness and Clark’s level of invasion for risk stratification of T1 cutaneous melanoma. Methods  From 1990 to 2008, the Swedish Melanoma Register included 97% of all melanomas diagnosed in Sweden. Altogether, 13 026 patients
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Gomes, Rafael Antunes. "Estudo comparativo da análise citológica e histopatológica de massas cutâneas e subcutâneas em cães e gatos." Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2015. http://hdl.handle.net/10400.5/8864.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A análise citológica consiste num exame complementar que pode ser fonte de informação diagnóstica relevante para qualquer clínico de pequenos animais. De baixo custo e de relativa facilidade de execução, a análise citológica pode facilmente ser integrada nos exames de diagnóstico proporcionados por qualquer centro veterinário. A avaliação microscópica das amostras citológicas pode ser feita diretamente pelo clínico, sendo requerida alguma dedicação e prática, ou serem enviadas para laboratórios externos onde são avaliadas por profiss
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FERREIRA, Steffany de Almeida. "Análise da expressão de glicosiltransferases em tumores cutâneos não melanomas." Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/12756.

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Submitted by Amanda Silva (amanda.osilva2@ufpe.br) on 2015-04-08T15:05:36Z No. of bitstreams: 2 Dissertação Steffany Ferreira 2012.pdf: 970478 bytes, checksum: 8ca9a2d6fdbc3bdbf9c13613ab646b16 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5)<br>Made available in DSpace on 2015-04-08T15:05:36Z (GMT). No. of bitstreams: 2 Dissertação Steffany Ferreira 2012.pdf: 970478 bytes, checksum: 8ca9a2d6fdbc3bdbf9c13613ab646b16 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2012<br>O câncer de pele ou tumor cutâneo
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Lobo, Cláudia Marina Santos. "Mastocitoma cutâneo canino." Master's thesis, 2019. http://hdl.handle.net/10400.26/29784.

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O mastocitoma (MTC) é a neoplasia cutânea mais comum em cães. Apresenta uma clara predisposição racial descrita em diferentes estudos, e um prognóstico muito variável. Este estudo teve como objetivos realizar a caracterização de uma população de cães com mastocitoma cutâneo e determinar os fatores de risco e fatores de prognóstico associados. No presente estudo foram avaliados, de forma retrospetiva, 48 casos clínicos de mastocitomas cutâneos caninos diagnosticados entre Julho de 2014 e Dezembro de 2018 no Centro Hospitalar Veterinário, do Porto, Portugal. Foram analisados os seguintes d
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Martins, Ana Luísa Mendes Pereira. "Canine cutaneous tumors: epidemiological and molecular insights." Master's thesis, 2020. https://hdl.handle.net/10216/132080.

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Martins, Ana Luísa Mendes Pereira. "Canine cutaneous tumors: epidemiological and molecular insights." Dissertação, 2020. https://hdl.handle.net/10216/132080.

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Kastnerova, Liubov. "Klinickopatologické a molekulárně biologické charakteristiky vybraných kožních epiteliálních a neepiteliálních nádorů." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-404756.

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The doctoral thesis MD. Liubov Kastnerova (previous name Kyrpychova) is focused on the histomorphological and molecular biologic features of selected cutaneous epithelial and nonepithelial tumors and is structured as a commentary to the 20 articles published during four years, representing the completed scientific projects in the Ph.D. course. In eight papers, the author of the thesis is the first author, whereas she coauthored in the remaining 12 papers. The thesis is composed of the commented files of authors own publications and it is divided into cutaneous epithelial and nonepithelial tumo
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Wang, Hui-Ju, and 王慧如. "Clinical outcome in dogs with cutaneous mast cell tumors treated with neoadjuvant prednisolone and surgical excision." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/zb42j3.

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碩士<br>國立中興大學<br>獸醫學系暨研究所<br>103<br>Mast cell tumors (MCTs) are most common cutaneous tumors in dogs, which have various biological behaviors. Prednisolone, as a neoadjuvant, is widely used in the treatment of MCTs, and without reported postoperative complications. The aims of this study were to evaluate the relapse free interval (RFI), overall survival time (OST), and locoregional recurrence of dogs with MCTs after receiving oral prednisolone at a dose of 40 mg/m2 body surface area (BSA) once daily and assigning to follow with or without surgery. The MCTs were graded by modified 2-tier histolo
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Teng, Shr-Ping, and 滕世平. "Evaluation of Prednisolone in Treatment of Canine Cutaneous Mast Cell Tumors and Immunohistochemical Detection of KIT, P-glycoprotein, STAT3, and phospho-STAT3 in Mast Cell Tumors." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/35349721524003063261.

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碩士<br>國立中興大學<br>獸醫學系暨研究所<br>98<br>Prednisolone (PRD), a class of glucocorticoid (GC), is commonly used in the treatment of canine mast cell tumors (MCTs). While many MCTs are resistant to GCs at initially or gradually develops upon repeated treatments. Recently, several studies indicated P-glycoprotein (PGP), a drug efflux transporter, and signal transducers and activators of transcription 3 (STAT3) oncogenic proteins may contribute to GC-resistance. In addition, KIT, a well known prognostic factor in MCTs, may also influence the tumor response to PRD. The aims of this study were to evaluate o
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Yang, Cho-Hau, and 楊筑皓. "Association between expressions of KIT with PI3K/AKT/mTOR signal transduction pathway and clinicopathological factors in canine cutaneous mast cell tumors." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/00620059531868221637.

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碩士<br>國立中興大學<br>獸醫學系暨研究所<br>102<br>Mast cell tumors (MCTs) are one of the most common cutaneous tumors in the dog. This study aimed to evaluate KIT, PI3K, Akt, p-Akt, mTOR and p-mTOR expression in 50 canine cutaneous MCTs and investigate the correlations between the proteins mentioned above and clinicopathologic parameters by the immunohistochemical staining and immunoreactive score system. There were three KIT immunostaining patterns that are pattern I: primarily along the cytoplasmic membrane, pattern II: the intense, focally clustered cytoplasmic KIT staining, and pattern III: diffuse cytop
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Greene, Victoria R. Ellerhorst Julie Piller Linda Beth Diamond Pamela M. "NRAS and BRAF mutations in primary cutaneous melanoma : a comparison of mutation rates between radial and vertical growth phases in individual tumors." 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1444902.

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Thesis (M.P.H.)--University of Texas Health Science Center at Houston, School of Public Health, 2007.<br>Source: Masters Abstracts International, Volume: 46-01, page: 0342. Adviser: Julie Ellerhorst. Includes bibliographical references.
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