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Journal articles on the topic 'Cvd'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 June 2025

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1

Jadoon, Adil, Anna V. Mathew, Jaeman Byun, et al. "Gut Microbial Product Predicts Cardiovascular Risk in Chronic Kidney Disease Patients." American Journal of Nephrology 48, no. 4 (2018): 269–77. http://dx.doi.org/10.1159/000493862.

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Background: The gut microbiota is altered in patients with chronic kidney disease (CKD), and cardiovascular risk increases with progressive CKD. This study examined the potential link between short chain fatty acids (SCFAs), which are produced by the gut microbiota, and cardiovascular outcomes in patients with CKD. Methods: SCFAs were measured using a targeted liquid chromatography-mass spectrometry platform in baseline plasma samples from 214 patients with CKD enrolled in the Clinical Phenotyping Resource and Biobank Core; 81 patients with coronary artery disease (CAD) and 133 without CAD wer

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Butcko, Andrew J., Ashley K. Putman, and Emilio P. Mottillo. "The Intersection of Genetic Factors, Aberrant Nutrient Metabolism and Oxidative Stress in the Progression of Cardiometabolic Disease." Antioxidants 13, no. 1 (2024): 87. http://dx.doi.org/10.3390/antiox13010087.

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Cardiometabolic disease (CMD), which encompasses metabolic-associated fatty liver disease (MAFLD), chronic kidney disease (CKD) and cardiovascular disease (CVD), has been increasing considerably in the past 50 years. CMD is a complex disease that can be influenced by genetics and environmental factors such as diet. With the increased reliance on processed foods containing saturated fats, fructose and cholesterol, a mechanistic understanding of how these molecules cause metabolic disease is required. A major pathway by which excessive nutrients contribute to CMD is through oxidative stress. In

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Wang, Hanghang, Patrick H. Pun, Lydia Kwee, et al. "Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization." Cardiorenal Medicine 7, no. 2 (2016): 96–103. http://dx.doi.org/10.1159/000453458.

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Background: While the association between APOL1 genetic variants and chronic kidney disease (CKD) has been established, their association with cardiovascular disease (CVD) is unclear. This study sought to understand CKD and cardiovascular risk conferred by APOL1 variants in a secondary cardiovascular prevention population. Methods: Two risk variants in APOL1 were genotyped in African-Americans (n = 1,641) enrolled in the CATHGEN biorepository, comprised of patients referred for cardiac catheterization at Duke University Hospital, Durham, NC, USA (2001-2010). Individuals were categorized as non

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Solmi, M., N. Veronese, B. Beatrice, et al. "Prevalence, incidence and comparative meta-analysis of all-cause and specific-cause cardiovascular disease in patients with serious mental illness." European Psychiatry 41, S1 (2017): S319—S320. http://dx.doi.org/10.1016/j.eurpsy.2017.02.238.

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Patients with severe mental illness (SMI) have been described at higher risk of cardiovascular disease (CVD). The aim of this systematic review and meta-analysis was to quantify prevalence, incidence, cross-sectional association and longitudinal increased risk of coronary heart disease (CHD), stroke, transient ischemic attack and cerebrovascular disease (CBVD), heart failure (HF), peripheral vascular disease (PVD), death due to CVD, and any CVD in patients with SMI. We included 92 studies, with a total population of 3,371,461 patients (BD = 241,226, MDD = 476,102, SCZ = 1,721,586, SMI = 932,54

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Gujral, Unjali P., Ram Jagannathan, Siran He, et al. "Association between varying cut-points of intermediate hyperglycemia and risk of mortality, cardiovascular events and chronic kidney disease: a systematic review and meta-analysis." BMJ Open Diabetes Research & Care 9, no. 1 (2021): e001776. http://dx.doi.org/10.1136/bmjdrc-2020-001776.

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IntroductionWe conducted a systematic review and meta-analysis to evaluate the updated evidence regarding prediabetes for predicting mortality, macrovascular and microvascular outcomes.Research design and methodsWe identified English language studies from MEDLINE, PubMed, OVID and Cochrane database indexed from inception to January 31, 2020. Paired reviewers independently identified 106 prospective studies, comprising nearly 1.85 million people, from 27 countries. Primary outcomes were all-cause mortality (ACM), cardiovascular mortality (CVDM), cardiovascular disease (CVD), coronary heart dise

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Liu, Yu-Jie, Meng-Yuan Miao, Jia-Min Wang, et al. "Coffee Consumption and Incidence of Cardiovascular and Microvascular Diseases in Never-Smoking Adults with Type 2 Diabetes Mellitus." Nutrients 15, no. 18 (2023): 3910. http://dx.doi.org/10.3390/nu15183910.

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The relationship between coffee consumption and diabetes-related vascular complications remains unclear. To eliminate confounding by smoking, this study assessed the relationships of coffee consumption with major cardiovascular disease (CVD) and microvascular disease (MVD) in never-smokers with type 2 diabetes mellitus (T2DM). Included were 9964 never-smokers with T2DM from the UK Biobank without known CVD or cancer at baseline (7781 were free of MVD). Participants were categorized into four groups according to daily coffee consumption (0, 0.5–1, 2–4, ≥5 cups/day). CVD included coronary heart

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Spanuchart, Ittikorn, Arkom Nongnuch, and Youg Liu. "Nontraditional Biomarkers for Cardiovascular Disease in Patients With Chronic Kidney Disease." Ramathibodi Medical Journal 43, no. 2 (2020): 51–60. http://dx.doi.org/10.33165/rmj.2020.43.2.230208.

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Cardiovascular disease (CVD) is the leading cause of death among patients who have chronic kidney disease (CKD). Nowadays, CKD per se is considered one of the coronary heart disease (CHD) risk equivalents. Apart from traditional CVD risk factors, there are several possible determinants for CVD in patients with CKD, for example, uremic toxins, increased inflammatory stage, abnormal bone mineral metabolism, and positive calcium balance. In this narrative review, we offer a summary of the extensively studied biomarkers for CVD in patients with CKD, including uremic toxins (p-cresol, indoxyl sulfa

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Anderson, R. David, John W. Petersen, Puja K. Mehta, et al. "Prevalence of Coronary Endothelial and Microvascular Dysfunction in Women with Symptoms of Ischemia and No Obstructive Coronary Artery Disease Is Confirmed by a New Cohort: The NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation–Coronary Vascular Dysfunction (WISE-CVD)." Journal of Interventional Cardiology 2019 (March 11, 2019): 1–8. http://dx.doi.org/10.1155/2019/7169275.

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Objective. In a separate, contemporary cohort, we sought to confirm findings of the original Women’s Ischemia Syndrome Evaluation (WISE). Background. The original WISE observed a high prevalence of both invasively determined coronary endothelial and coronary microvascular dysfunction (CMD) that predicted adverse events in follow-up. Methods. We comparatively studied the WISE-Coronary Vascular Dysfunction (CVD) cohort (2009-2011), with signs and symptoms of ischemia but without significant CAD, to the original WISE (1997-2001) cohort. CMD was defined as coronary flow reserve (CFR) ≤2.5, or endo

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Shifris, I. M., I. O. Dudar, Е. К. Krasiuk, and А. Yu Shymova. "Predictors of cardiovascular disease in patients with chronic kidney disease VD stage treated with hemodialysis." Medicni perspektivi (Medical perspectives) 26, no. 2 (2021): 59–66. http://dx.doi.org/10.26641/2307-0404.2021.2.234513.

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The aim of the study was to establish the frequency and possible predictors of cardiovascular disease (CVD) in chronic kidney disease (CKD) VD stage patients, treated with hemodialysis, based on results of prospective observation. The prospective observational cohort study included 223 patients with CKD V D stage who were treated with hemodialysis (HD) during 2012-2019. The research was carried out in two stages. At the first stage, main demographic, laboratory and clinical characteristics of patients, including the frequency of CVD, at the time of beginning the study were examined. At the sec

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Shifris, I.M., I.O. Dudar, Е.К. Krasiuk, and А.Yu. Shymova. "Predictors of cardiovascular disease in patients with chronic kidney disease VD stage treated with hemodialysis." Medicni perspektivi 26, no. 2 (2021): 59–66. https://doi.org/10.26641/2307-0404.2021.2.234513.

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The aim of the study was to establish the frequency and possible predictors of cardiovascular disease (CVD) in chronic kidney disease (CKD) VD stage patients, treated with hemodialysis, based on results of prospective observation. The prospective observational cohort study  included 223 patients with CKD V D stage who were treated with hemodialysis (HD) during 2012-2019. The research was carried out in two stages. At the first stage, main demographic, laboratory and clinical characteristics of patients, including the frequency of CVD, at the time of beginning the study were examined. At t

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Kosmas, Constantine E., Shanna Rodriguez Polanco, Maria D. Bousvarou, et al. "The Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio as a Risk Marker for Metabolic Syndrome and Cardiovascular Disease." Diagnostics 13, no. 5 (2023): 929. http://dx.doi.org/10.3390/diagnostics13050929.

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Atherosclerosis is an immunoinflammatory pathological procedure in which lipid plaques are formed in the vessel walls, partially or completely occluding the lumen, and is accountable for atherosclerotic cardiovascular disease (ASCVD). ACSVD consists of three components: coronary artery disease (CAD), peripheral vascular disease (PAD) and cerebrovascular disease (CCVD). A disturbed lipid metabolism and the subsequent dyslipidemia significantly contribute to the formation of plaques, with low-density lipoprotein cholesterol (LDL-C) being the main responsible factor. Nonetheless, even when LDL-C

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Gosmanova, Elvira O., and Ngoc-Anh Le. "Cardiovascular Complications in CKD Patients: Role of Oxidative Stress." Cardiology Research and Practice 2011 (2011): 1–8. http://dx.doi.org/10.4061/2011/156326.

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Starting with the early stages, patients with chronic kidney disease (CKD) experience higher burden of cardiovascular disease (CVD). Moreover, CVD complications are the major cause of mortality in CKD patients as compared with complications from chronic kidney failure. While traditional CVD risk factors, including diabetes, hypertension, hyperlipidemia, obesity, physical inactivity, may be more prevalent among CKD patients, these factors seem to underestimate the accelerated cardiovascular disease in the CKD population. Search for additional biomarkers that could explain the enhanced CVD risk

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Villain, Cédric, Marie Metzger, Christian Combe, et al. "Prevalence of atheromatous and non-atheromatous cardiovascular disease by age in chronic kidney disease." Nephrology Dialysis Transplantation 35, no. 5 (2018): 827–36. http://dx.doi.org/10.1093/ndt/gfy277.

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Abstract Background Although chronic kidney disease (CKD) and age are major risk factors for cardiovascular disease (CVD), little is known about the relative proportions of atheromatous and non-atheromatous CVD by age in CKD patients. Methods We used baseline data from the French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort of 3033 patients (65% men) with CKD Stages 3–4 to study crude and adjusted associations between age, the estimated glomerular filtration rate (eGFR), atheromatous CVD (coronary artery disease, peripheral artery disease and stroke) and

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Sheer, Richard, Radhika Nair, Margaret K. Pasquale, et al. "Predictive Risk Models to Identify Patients at High-Risk for Severe Clinical Outcomes With Chronic Kidney Disease and Type 2 Diabetes." Journal of Primary Care & Community Health 13 (January 2022): 215013192110637. http://dx.doi.org/10.1177/21501319211063726.

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Introduction/Objective: Predictive risk models identifying patients at high risk for specific outcomes may provide valuable insights to providers and payers regarding points of intervention and modifiable factors. The goal of our study was to build predictive risk models to identify patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) at high risk for progression to end stage kidney disease (ESKD), mortality, and hospitalization for cardiovascular disease (CVD), cerebrovascular disease (CeVD), and heart failure (HF). Methods: This was a retrospective observational cohort study

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Adiyanti, Sri Suryo, Yusra Yusra, Suzanna Immanuel, Diana Aulia, Fify Henrika, and July Kumalawati. "The Role of Neutrophil Lymphocyte Ratio , Vitamin D, and NGAL as Cardiovascular Disease Marker in Chronic Kidney Disease." eJournal Kedokteran Indonesia 9, no. 3 (2022): 192–6. http://dx.doi.org/10.23886/ejki.9.35.192-6.

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Chronic kidney disease (CKD) patients have higher risk to develop cardiovascular disease (CVD) than non-CKD patients. Neutrophil lymphocyte ratio (NLR) in CKD patients reflects inflammation status and role as complementary prognostic marker to evaluate cardiovascular risk in stage 3 to 5 CKD. High prevalence of vitamin D deficiency commonly found in CKD patients, leads to endothelial dysfunction and increase inflammation. NGAL is used as renal injury biomarker but nowadays NGAL has been known plays important role in CVD pathophysiology. CVD identification in CKD patients is necessary to obtain

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Wijnands, K. P. J., S. A. Obermann-Borst, E. J. G. Sijbrands, M. F. Wildhagen, W. A. Helbing, and R. P. M. Steegers-Theunissen. "Cardiovascular diseases in grandparents and the risk of congenital heart diseases in grandchildren." Journal of Developmental Origins of Health and Disease 5, no. 2 (2014): 152–58. http://dx.doi.org/10.1017/s2040174414000026.

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Hyperglycemia, dyslipidemia and hyperhomocysteinemia are associated with both adult cardiovascular disease (CVD) and having a child with a congenital heart disease (CHD). We investigated associations between CVD in grandparents and the risk of CHD in grandchildren. In a case–control family study, we obtained detailed questionnaire information on CVD and CHD in 247 families with a CHD child and 203 families without a CHD child. Grandparents with CVD or intermittent claudication (IC) were significantly associated with an increased risk for CHD in grandchildren [OR 1.39 (95% CI 1.03–1.89) and OR

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Kosmas, Constantine E., Delia Silverio, Christiana Tsomidou, Maria D. Salcedo, Peter D. Montan, and Eliscer Guzman. "The Impact of Insulin Resistance and Chronic Kidney Disease on Inflammation and Cardiovascular Disease." Clinical Medicine Insights: Endocrinology and Diabetes 11 (January 2018): 117955141879225. http://dx.doi.org/10.1177/1179551418792257.

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There is extensive evidence showing that insulin resistance (IR) is associated with chronic low-grade inflammation. Furthermore, IR has been shown to increase the risk for cardiovascular disease (CVD), even in nondiabetic patients, and is currently considered as a “nontraditional” risk factor contributing to CVD by promoting hypertension, oxidative stress, endothelial dysfunction, dyslipidemia, and type 2 diabetes mellitus. However, chronic kidney disease (CKD) is also considered a state of low-grade inflammation. In addition, CKD is considered an IR state and has been described as an independ

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Chacko, Manas, P. Sankara Sarma, Sivadasanpillai Harikrishnan, Geevar Zachariah, and Panniyammakal Jeemon. "Family history of cardiovascular disease and risk of premature coronary heart disease: A matched case-control study." Wellcome Open Research 5 (April 16, 2020): 70. http://dx.doi.org/10.12688/wellcomeopenres.15829.1.

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Background: Self-reported family history of cardiovascular disease (CVD) is an independent risk factor for future coronary heart disease (CHD) events. However, inclusion of family history of CVD in the traditional risk scores failed to improve risk prediction of CHD. It is proposed that family history of CVD may substantially increase the risk of CHD among younger individuals. Methods: We conducted a matched case-control study with 170 hospital-based premature CHD patients (<55 years in men and <65 years in women) from a tertiary care centre in Thiruvananthapuram, Kerala and age and sex

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Chacko, Manas, P. Sankara Sarma, Sivadasanpillai Harikrishnan, Geevar Zachariah, and Panniyammakal Jeemon. "Family history of cardiovascular disease and risk of premature coronary heart disease: A matched case-control study." Wellcome Open Research 5 (June 12, 2020): 70. http://dx.doi.org/10.12688/wellcomeopenres.15829.2.

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Background: Self-reported family history of cardiovascular disease (CVD) is an independent risk factor for future coronary heart disease (CHD) events. However, inclusion of family history of CVD in the traditional risk scores failed to improve risk prediction of CHD. It is proposed that family history of CVD may substantially increase the risk of CHD among younger individuals. Methods: We conducted a matched case-control study with 170 hospital-based premature CHD patients (<55 years in men and <65 years in women) from a tertiary care centre in Thiruvananthapuram, Kerala and age and sex

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Song, Jenn-Yeu, Ta-Chung Shen, Yi-Chou Hou, et al. "Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease." International Journal of Molecular Sciences 21, no. 17 (2020): 6294. http://dx.doi.org/10.3390/ijms21176294.

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Cardiovascular disease (CVD) is closely related to chronic kidney disease (CKD), and patients with CKD have a high risk of CVD-related mortality. Traditional CVD risk factors cannot account for the higher cardiovascular risk of patients with CKD, and standard CVD interventions cannot reduce the mortality rates among patients with CKD. Nontraditional factors related to mineral and vitamin-D metabolic disorders provide some explanation for the increased CVD risk. Non-dialyzable toxins, indoxyl sulfate (IS) and p-cresol sulfate (PCS)—produced in the liver by colonic microorganisms—cause kidney an

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Mamdouh, Doaa, Hanan Shawky, Nihal Moustafa El-Assaly, et al. "Role of Transcription Factor 7 like 2 and Silent Information Regulator 1 Genes in the Development of Cardiovascular Complications in a Group of Egyptian Patients with Chronic Kidney Disease." Open Access Macedonian Journal of Medical Sciences 10, A (2022): 16–24. http://dx.doi.org/10.3889/oamjms.2022.8107.

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BACKGROUND: Sirtuins silent information regulator 1 (SIRT) is histone deacetylases that act as antioxidants and involved in the pathogenesis of cardiovascular diseases (CVD) which are the major complications of chronic kidney disease (CKD). Transcription factor 7-like 2 (TCF7L2) genetic polymorphisms could contribute to the risk of CVD as TCF7L2 proteins regulate vascular remodeling. AIM: We tried to demonstrate the role of genetic polymorphisms: rs7069102 and rs10823108 in SIRT1 gene and rs7903146 in TCF7L2 gene in the development of CVD in CKD Egyptian patients. METHODS: This study included

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Obialo, Chamberlain, Elizabeth Ofili, and Keith Norris. "Statins and Cardiovascular Disease Outcomes in Chronic Kidney Disease: Reaffirmation vs. Repudiation." International Journal of Environmental Research and Public Health 15, no. 12 (2018): 2733. http://dx.doi.org/10.3390/ijerph15122733.

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Cardiovascular disease (CVD) burden is several-fold higher in patients with chronic kidney disease (CKD). Although statins have been shown to provide significant CVD benefits in both the general population and patients with CKD, this has not translated into survival advantage in patients with advanced CKD or on dialysis. It has been reported that CVD risk continues to escalate as CKD progresses to end-stage kidney disease (ESKD); however, the CVD risk reduction by statins appears to decline as patients’ progress from the early to later stages of CKD. Statins have also been associated with a hi

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Pagliano, G., L. Orlando, and A. Gravina. "Detección y caracterización del complejo de viroides de los cítricos en Uruguay." Agrociencia 2, no. 1 (1998): 74–83. http://dx.doi.org/10.31285/agro.02.1143.

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Plantas de cidro Etrog Arizona 861 (Citrus medica L.) fueron inoculadas con cortezas provenientes de árboles de campo presentando síntomas de enanismo y descortezado del portainjerto y de árboles asintomáticos. A los 3 y 4 meses expresaron reducción del crecimiento, epinastia en hojas, necrosis de nervaduras, puntuaciones en peciolo y síntomas de shock. El análisis de ácidos nucleicos mediante sPAGE, slot blot e hibridación molecular, permitió detectar la presencia de tres grupos de viroides, CVd-I, CVd-II y CVd-III comunicados por primera vez a nivel nacional, asociados al agente causal de la

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Yew, Sheng Qian, Yook Chin Chia, and Michael Theodorakis. "Assessing 10-Year Cardiovascular Disease Risk in Malaysians With Type 2 Diabetes Mellitus: Framingham Cardiovascular Versus United Kingdom Prospective Diabetes Study Equations." Asia Pacific Journal of Public Health 31, no. 7 (2019): 622–32. http://dx.doi.org/10.1177/1010539519873487.

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In this study, we evaluated the performance of the Framingham cardiovascular disease (CVD) and the United Kingdom Prospective Diabetes Study (UKPDS) risk equations to predict the 10-year CVD risk among type 2 diabetes mellitus (T2DM) patients in Malaysia. T2DM patients (n = 660) were randomly selected, and their 10-year CVD risk was calculated using both the Framingham CVD and UKPDS risk equations. The performance of both equations was analyzed using discrimination and calibration analyses. The Framingham CVD, UKPDS coronary heart disease (CHD), UKPDS Fatal CHD, and UKPDS Stroke equations have

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Swamy, Sowmya, Sahibzadi Mahrukh Noor, and Roy O. Mathew. "Cardiovascular Disease in Diabetes and Chronic Kidney Disease." Journal of Clinical Medicine 12, no. 22 (2023): 6984. http://dx.doi.org/10.3390/jcm12226984.

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Chronic kidney disease (CKD) is a common occurrence in patients with diabetes mellitus (DM), occurring in approximately 40% of cases. DM is also an important risk factor for cardiovascular disease (CVD), but CKD is an important mediator of this risk. Multiple CVD outcomes trials have revealed a greater risk for CVD events in patients with diabetes with CKD versus those without. Thus, reducing the risk of CKD in diabetes should result in improved CVD outcomes. To date, of blood pressure (BP) control, glycemic control, and inhibition of the renin-angiotensin system (RASI), glycemic control appea

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Quan, Stuart, Rohit Budhiraja, Sogol Javaheri, Sairam Parthasarathy, and Richard Berry. "The Association Between Obstructive Sleep Apnea Defined by 3 Percent Oxygen Desaturation or Arousal Definition and Self-Reported Cardiovascular Disease in the Sleep Heart Health Study." Southwest Journal of Pulmonary and Critical Care 21, no. 4 (2020): 86–103. http://dx.doi.org/10.13175/swjpcc054-20.

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Background: Studies have established that OSA defined using a hypopnea definition requiring a >4% oxygen desaturation (AHI4%) is associated with cardiovascular (CVD) or coronary heart (CHD) disease. This study determined whether OSA defined using a hypopnea definition characterized by a >3% oxygen desaturation or an arousal (AHI3%A) is associated with CVD/CHD. Methods: Data were analyzed from 6307 Sleep Heart Health Study participants who had polysomnography. Self-reported CVD included angina, heart attack, heart failure, stroke or previous coronary bypass surgery or angioplasty. Self-re

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Vallianou, Natalia G., Shah Mitesh, Agathoniki Gkogkou, and Eleni Geladari. "Chronic Kidney Disease and Cardiovascular Disease: Is there Any Relationship?" Current Cardiology Reviews 15, no. 1 (2018): 55–63. http://dx.doi.org/10.2174/1573403x14666180711124825.

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Introduction: Chronic Kidney Disease is a growing health burden world wide. Traditional and mutual risk factors between CVD and CKD are age, hypertension, diabetes mellitus, dyslipidemia, tobacco use, family history and male gender. In this review, we will focus on whether or not early CKD is an important risk factor for the presence, severity and progression of CVD. Specifically, we will examine both traditional and novel risk factors of both CKD and CVD and how they relate to each other. Conclusion: We will also assess if early treatment of CKD, intensive compared to standard, has an importa

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Twardawa, Mateusz, Piotr Formanowicz, and Dorota Formanowicz. "The Interplay Between Carotid Intima-Media Thickness and Selected Serum Biomarkers in Various Stages of Chronic Kidney Disease." Biomedicines 13, no. 2 (2025): 335. https://doi.org/10.3390/biomedicines13020335.

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Background/Objectives: Chronic kidney disease (CKD), the most common cause of which is hypertension and diabetes, is a recognized risk factor for cardiovascular disease (CVD). This study investigated the association between selected serum biomarkers in the context of intima-media thickness (IMT) changes, a common predictor of subsequent cardiovascular (CV) events. Methods: A total of 251 individuals were enrolled in the study, divided into groups based on the severity of CKD, the presence of CVD, and healthy controls. For this purpose, the data from the following groups of participants were an

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Tohidi, Maryam, Arash Derakhshan, Samaneh Akbarpour, et al. "Thyroid Dysfunction States and Incident Cardiovascular Events: The Tehran Thyroid Study." Hormone and Metabolic Research 50, no. 01 (2017): 37–43. http://dx.doi.org/10.1055/s-0043-121031.

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AbstractThe objective of the study was to investigate the relation of different thyroid function states with the incidence of cardiovascular disease (CVD)/coronary heart disease (CHD) among a Middle-Eastern population with a high incidence of CVD/CHD. A total of 3975 participants entered the study (43.6% men). According to their thyroid stimulating hormone (TSH) and free thyroxin (FT4) levels, the participants were categorized into 5 groups: euthyroid, subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism, and overt hyperthyroidism. Multivariable Cox proportional hazard

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Al-Makhamreh, Hanna, Amro Alkhatib, Ahmed Attarri, et al. "Knowledge of cardiovascular disease risk factors among caregivers of cardiology patients attending Jordan University Hospital." PeerJ 12 (January 31, 2024): e16830. http://dx.doi.org/10.7717/peerj.16830.

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Cardiovascular disease (CVD) is an umbrella term that includes various pathologies involving the heart and the vasculature system of the body. CVD is the leading cause of death worldwide, accounting for an estimated 32% of all deaths. More than 40% of annual deaths in Jordan are due to CVD; this number is further expected to rise, particularly in the Eastern Mediterranean region where Jordan is located. Due to the chronic nature of CVD, the presence of a caregiver who can help mitigate the challenges patients face is essential, and their level of knowledge determines the quality of care they c

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Crawford, Andrew A., Stefan Soderberg, Clemens Kirschbaum, et al. "Morning plasma cortisol as a cardiovascular risk factor: findings from prospective cohort and Mendelian randomization studies." European Journal of Endocrinology 181, no. 4 (2019): 429–38. http://dx.doi.org/10.1530/eje-19-0161.

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Objective The identification of new causal risk factors has the potential to improve cardiovascular disease (CVD) risk prediction and the development of new treatments to reduce CVD deaths. In the general population, we sought to determine whether cortisol is a causal risk factor for CVD and coronary heart disease (CHD). Design and methods Three approaches were adopted to investigate the association between cortisol and CVD/CHD. First, we used multivariable regression in two prospective nested case-control studies (total 798 participants, 313 incident CVD/CHD with complete data). Second, a ran

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Ravid, Jonathan D., and Vipul C. Chitalia. "Molecular Mechanisms Underlying the Cardiovascular Toxicity of Specific Uremic Solutes." Cells 9, no. 9 (2020): 2024. http://dx.doi.org/10.3390/cells9092024.

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Mounting evidence strongly suggests a causal link between chronic kidney disease (CKD) and cardiovascular disease (CVD). Compared with non-CKD patients, patients with CKD suffer disproportionately from CVD and derive suboptimal benefits from interventions targeting conventional CVD risk factors. Uremic toxins (UTs), whose plasma levels rapidly rise as CKD progresses, represent a unique risk factor in CKD, which has protean manifestations on CVD. Among the known UTs, tryptophan metabolites and trimethylamine N-oxide are well-established cardiovascular toxins. Their molecular mechanisms of effec

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Bhargava, Seema, Arif Ali, Mamta Kankra, et al. "Differential expression of lipid peroxidation and total antioxidant status in Indian patients with cardiovascular and cerebrovascular disease." Canadian Journal of Physiology and Pharmacology 92, no. 7 (2014): 592–97. http://dx.doi.org/10.1139/cjpp-2013-0481.

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Data from studies examining lipid peroxidation as a mechanism involved with hyperhomocysteinemia (HHcy)-induced vascular remodeling in patients with occlusive vascular disease have been contradictory. It has not yet been studied in Indians within the context of atherogenesis. Therefore, we measured the levels of homocysteine (Hcy), malondialdehyde (MDA) as a measure of lipid peroxides (LPOs), and total antioxidant status (TAS) in the serum of 167 patients with occlusive vascular disease [coronary artery disease (CAD) = 43; cerebrovascular disease (CVD) = 82; peripheral vascular disease (PVD) =

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Vernière, C., X. Perrier, C. Dubois, et al. "Interactions Between Citrus Viroids Affect Symptom Expression and Field Performance of Clementine Trees Grafted on Trifoliate Orange." Phytopathology® 96, no. 4 (2006): 356–68. http://dx.doi.org/10.1094/phyto-96-0356.

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Citrus exocortis viroid (CEVd), Citrus bent leaf viroid (CBLVd), a noncachexia variant of Hop stunt viroid (HSVd), Citrus viroid III (CVd-III), and Citrus viroid IV (CVd-IV) were co-inoculated as two-, three-, four-, and five-viroid mixtures to Clementine trees grafted on trifoliate orange to evaluate their effect on symptom expression, tree growth, and fruit yield. Most trees infected with CEVd-containing viroid mixtures developed exocortis scaling symptoms, as did CEVd alone, whereas most trees infected with HSVd- or CVd-IV-containing mixtures developed bark-cracking symptoms. Trees infected

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Karangizi, A. H. K., D. Chanouzas, A. Fenton, et al. "Cytomegalovirus seropositivity is independently associated with cardiovascular disease in non-dialysis dependent chronic kidney disease." QJM: An International Journal of Medicine 113, no. 4 (2019): 253–57. http://dx.doi.org/10.1093/qjmed/hcz258.

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Abstract Background Cardiovascular disease (CVD) is the leading cause of early death in patients with chronic kidney disease (CKD). Previous work has described an association between Cytomegalovirus (CMV) seropositivity and CVD amongst patients with dialysis dependent end stage renal disease. Whether CMV seropositivity is associated with CVD in non-dialysis dependent CKD has not been established. Aim Investigate whether past CMV infection is associated with prevalent CVD in patients with non-dialysis dependent CKD. Design A retrospective observational study using the Renal Impairment in Second

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Timofeev, Yu S., A. A. Yafarova, A. F. Sheptulina, et al. "Comparative analysis of serum galanin levels in patients with coronary artery disease with and without heart failure with reduced ejection fraction and in individuals without cardiovascular diseases." Cardiovascular Therapy and Prevention 23, no. 10 (2024): 4156. http://dx.doi.org/10.15829/1728-8800-2024-4156.

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Aim. To study the level of the neuro-regulatory peptide galanin in patients with coronary artery disease (CAD) with and without heart failure with reduced ejection fraction (HFrEF) in comparison with individuals without cardiovascular disease (CVD) included in the control group.Material and methods. The study included 80 male patients as follows: 30 patients with CAD and HFrEF; 30 patients with CAD and without HFrEF; 20 individuals without CVD (control group). The groups were comparable in age and body mass index (BMI).Results. The median (Me) age of patients with CAD and HFrEF was 67,5 yea

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Alzyood, Laith, Tina Goa, Einstein Sanish Sathyan, et al. "64 Effect modification of familial longevity on the association between kidney dysfunction, cardiovascular disease, and mortality." Journal of Clinical and Translational Science 9, s1 (2025): 20. https://doi.org/10.1017/cts.2024.743.

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Objectives/Goals: Objective: To examine whether familial longevity modifies the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD) in older adults. Goals include assessing the impact of familial longevity on 1) CVD prevalence, 2) CVD incidence, and 3) mortality among individuals with CKD. Methods/Study Population: An observational, longitudinal study. We examined 1,236 Ashkenazi Jewish adults (ages 65–94) from the LonGenity cohort. Estimated glomerular filtration rate (eGFR) was the independent variable, calculated using the CKD-EPI equation 2021. CVD prevalence

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Wong, Chun Wai, Chun Shing Kwok, Aditya Narain, et al. "Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis." Heart 104, no. 23 (2018): 1937–48. http://dx.doi.org/10.1136/heartjnl-2018-313005.

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BackgroundThe influence of marital status on the incidence of cardiovascular disease (CVD) and prognosis after CVD is inconclusive. We systematically reviewed the literature to determine how marital status influences CVD and prognosis after CVD.MethodsA search of MEDLINE and Embase in January 2018 without language restriction was performed to identify studies that evaluated the association between marital status and risk of CVD. Search terms related to both marital status and CVD were used and included studies had to be prospective in design. The outcomes of interest were CVD, coronary heart d

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Maas, Sanne L., Marjo M. P. C. Donners, and Emiel P. C. van der Vorst. "ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?" International Journal of Molecular Sciences 24, no. 8 (2023): 7309. http://dx.doi.org/10.3390/ijms24087309.

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Chronic kidney disease (CKD) is a major health problem, affecting millions of people worldwide, in particular hypertensive and diabetic patients. CKD patients suffer from significantly increased cardiovascular disease (CVD) morbidity and mortality, mainly due to accelerated atherosclerosis development. Indeed, CKD not only affects the kidneys, in which injury and maladaptive repair processes lead to local inflammation and fibrosis, but also causes systemic inflammation and altered mineral bone metabolism leading to vascular dysfunction, calcification, and thus, accelerated atherosclerosis. Alt

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Tain, You-Lin, and Chien-Ning Hsu. "Cardiovascular Risks of Hypertension: Lessons from Children with Chronic Kidney Disease." Children 9, no. 11 (2022): 1650. http://dx.doi.org/10.3390/children9111650.

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Hypertension is the most common complication of chronic kidney disease (CKD) in children, having a strong association with subsequential cardiovascular disease (CVD). In pediatric CKD, a considerable percentage of children with hypertension are undiagnosed or undertreated. Prior research has evaluated structural and functional markers of subclinical CVD and biomarkers in adults with CKD, while ideal biomarkers in pediatrics are still insufficiently studied. The ultimate goal of this review is to summarize what is currently known about state of hypertension, cardiovascular risk factors, and pot

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Tucker, Patrick S., Michael I. Kingsley, R. Hugh Morton, Aaron T. Scanlan, and Vincent J. Dalbo. "The Increasing Financial Impact of Chronic Kidney Disease in Australia." International Journal of Nephrology 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/120537.

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The aim of this investigation was to determine and compare current and projected expenditure associated with chronic kidney disease (CKD), renal replacement therapy (RRT), and cardiovascular disease (CVD) in Australia. Data published by Australia and New Zealand Dialysis and Transplant Registry, Australian Institute of Health and Welfare, and World Bank were used to compare CKD-, RRT-, and CVD-related expenditure and prevalence rates. Prevalence and expenditure predictions were made using a linear regression model. Direct statistical comparisons of rates of annual increase utilised indicator v

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Matsushita, Kunihiro, Josef Coresh, Yingying Sang, et al. "Abstract 55: Kidney Measures Beyond Conventional Risk Factors for Predicting Incident Cardiovascular Disease: A Collaborative Meta-Analysis of 16 Cohorts." Circulation 129, suppl_1 (2014). http://dx.doi.org/10.1161/circ.129.suppl_1.55.

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Introduction: Despite the high risk of cardiovascular disease (CVD) in those with chronic kidney disease (CKD), there are conflicting data as to whether two key kidney measures, estimated glomerular filtration rate (eGFR) and albuminuria, contribute to better CVD prediction, beyond conventional risk factors, warranting a more comprehensive investigation over a broad range of populations. Methods: We studied 127,825 participants without history of CVD from 12 general population, 3 high risk and 1 CKD cohorts with data on eGFR (based on the CKD-EPI creatinine equation) and urinary albumin-creati

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Hirabayashi, Ken, Hideki Fujii, Keiji Kono, et al. "#2496 ASSOCIATION OF ABNORMALITIES IN ELECTROCARDIOGRAPHY AND ECHOCARDIOGRAPHY WITH THE OCCURRENCE OF CARDIOVASCULAR DISEASE IN CHRONIC KIDNEY DISEASE." Nephrology Dialysis Transplantation 38, Supplement_1 (2023). http://dx.doi.org/10.1093/ndt/gfad063c_2496.

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Abstract Background and Aims In chronic kidney disease (CKD), the incidence of cardiovascular disease (CVD) increases along with CKD progression. Although coronary artery disease (CAD) is one of the most critical CVDs, it is difficult to identify CAD because its symptom is usually atypical in CKD. Consequently, appropriate screening tests for CVD are important in this population. Electrocardiography (ECG) and transthoracic echocardiography (TTE) are commonly performed in daily clinical practice, and we researched whether these abnormalities are risk factors for CVD including CAD in patients wi

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Kanneganti, Radha, Zeina Dardari, Roger S. Blumenthal, et al. "Abstract 13711: Coronary Artery Calcium, Ankle-brachial Index, High Sensitivity C-reactive Protein, and a Family History of Coronary Artery Disease as Predictors of Incident Cardiovascular Events at Different Stages of Hypertension: The Multi-ethnic Study of Atherosclerosis." Circulation 142, Suppl_3 (2020). http://dx.doi.org/10.1161/circ.142.suppl_3.13711.

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Background: Coronary artery calcium (CAC), ankle-brachial index (ABI), high-sensitivity CRP (hsCRP), and family history (FHx) of coronary artery disease (CAD) are used as complementary aids in cardiac risk stratification. The 2017 ACC/AHA hypertension guideline’s new Stage I hypertension group has created uncertainty regarding intensity of blood pressure (BP) treatment in this group. We evaluated the comparative utility of CAC, ABI, hsCRP and FHx CAD as risk predictors of cardiovascular (CVD) events within different BP strata. Methods: The MESA cohort was followed for a median of 13 years with

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Peng, Bo, Hong Yu Wang, Decontee Kaye, et al. "Abstract 11522: The Risk of Cardiovascular Diseases in Women with Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.11522.

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Introduction: Recurrent pregnancy loss (RPL) is defined as two or more ultrasound confirmed pregnancy losses or three or more pregnancy losses at any location. Evidence suggests that women with a history of RPL have an increased risk of coronary heart disease. However, the association between cardiovascular diseases (CVD) and RPL remains unclear. We aim to conduct a systematic review and meta-analysis to investigate whether RPL is a risk factor for CVD. Methods: Population-based studies on MEDLINE, CINAHL, Web of Science, and Embase that investigated the risk of CVD in women with or without a

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Gibbs, Sophia, Adrian Bacong, Lily Amaturo, et al. "Abstract P303: Investigating the Relationship Between Cardiovascular Diseases and Major Depressive Disorder Among Asians and Pacific Islanders." Circulation 149, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.149.suppl_1.p303.

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Background: Poorer mental health is associated with greater cardiovascular disease (CVD) morbidity, recovery, and mortality. Experiencing CVD is also associated with poorer mental health after a CVD event. What has been less examined, is how these associations differ among disaggregated Asian and Pacific Islander (API) groups who have a lower burden of both CVD and poor mental health relative to other racial groups. Objective: To examine the association between CVD diagnosis and experiencing major depressive disorder (MDD) among API people and how it differs between racial groups. Methods: We

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Cardarelli, Francesca, Antonio Bellasi, Stephen J. Onufrak, et al. "Abstract 3502: Serum Phosphorus Levels are Associated with Incident Fatal and Non-Fatal Coronary Disease in Men but not in Women in the Community." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_793-a.

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Mineral metabolism disorders are associated with coronary atherosclerosis and poor outcomes in chronic kidney disease (CKD) and cardiovascular disease (CVD) patients. A recent study suggested that elevated levels of serum phosphorus are associated with increased risk of CVD in subjects free from CKD and CVD. However, data suggest that the distribution of serum phosphorus differs by gender and it is not known whether phosphorus carries the same prognostic significance in men and in women. We tested the association of baseline serum phosphorus levels with incidence of CHD (myocardial infarction

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Arai, Hidenori, Yoshihiro Kokubo, Makoto Watanabe, Tatsuya Sawamura, Tomonori Okamura, and Yoshihiro Miyamato. "Abstract 8706: Impact of Small Dense Low-Density Lipoproteins Cholesterol on Cardiovascular Disease in an Urban Japanese Cohort: The Suita Study." Circulation 124, suppl_21 (2011). http://dx.doi.org/10.1161/circ.124.suppl_21.a8706.

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Aim: Increased plasma low-density lipoprotein cholesterol (LDL-C) concentrations have been shown to be one of the major risk factors for cardiovascular disease (CVD). Clinical evidence also indicates that small dense LDL (sd-LDL) particles are more atherogenic than large buoyant LDL particles. Because there was no easy assay to measure the amount of sd-LDL-C, few studies have addressed the association between sd-LDL-C and CVD. In this study, we hypothesized that higher sd-LDL-C is associated with increased risk for CVD. To this end, we examined the association between sd-LDL-C and CVD in Japan

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Hubbard, Demetria, Lisandro D. Colantonio, Robert S. Rosenson, et al. "Risk for recurrent cardiovascular disease events among patients with diabetes and chronic kidney disease." Cardiovascular Diabetology 20, no. 1 (2021). http://dx.doi.org/10.1186/s12933-021-01247-0.

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Abstract Background Adults who have experienced multiple cardiovascular disease (CVD) events have a very high risk for additional events. Diabetes and chronic kidney disease (CKD) are each associated with an increased risk for recurrent CVD events following a myocardial infarction (MI). Methods We compared the risk for recurrent CVD events among US adults with health insurance who were hospitalized for an MI between 2014 and 2017 and had (1) CVD prior to their MI but were free from diabetes or CKD (prior CVD), and those without CVD prior to their MI who had (2) diabetes only, (3) CKD only and

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Qing, Li, and Ling Wenhua. "Association of Serum Magnesium and Calcium - Magnesium Ratio with Mortality in Patients with Coronary Artery Disease (P18-090-19)." Current Developments in Nutrition 3, Supplement_1 (2019). http://dx.doi.org/10.1093/cdn/nzz039.p18-090-19.

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Abstract Objectives Low serum magnesium (Mg) and high serum calcium (Ca) levels have been linked to increased mortality and cardiovascular disease (CVD) in the general population. This prospective study assessed whether there were independent associations of serum Mg levels and Ca-Mg ratio with all-cause and CVD mortality among patients with coronary artery disease (CAD). Methods A prospective cohort study of 3380 CAD patients was conducted. Cox regression models were used to estimate the association of serum Mg levels and Ca-Mg ratio with the risk of mortality. Results During a median follow-

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