Academic literature on the topic 'CVM (cervicovaginal microbiota)'

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Journal articles on the topic "CVM (cervicovaginal microbiota)"

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Hand, Emily, Indriati Hood-Pishchany, Toni Darville, and Catherine M. O’Connell. "Influence of cervicovaginal microbiota on Chlamydia trachomatis infection dynamics." Microbial Cell 12 (2025): 93–108. https://doi.org/10.15698/mic2025.04.848.

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The cervicovaginal microbiome (CVM) is increasingly being considered as an important aspect of women’s health, particularly in relation to the risk and progression of sexually transmitted infections (STIs). CVM composition varies significantly between individuals and is shaped by factors including diet, age, environmental exposures, and lifestyle. Understanding these influences may shed light on how microbial imbalances contribute to infection susceptibility and the development of reproductive health disorders. Five distinct community state types (CSTs) classify common CVM compositions. Most C
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Onywera, Harris, Zizipho Z. A. Mbulawa, Adrian Brink, Anna-Lise Williamson, and Lamech M. Mwapagha. "Unravelling the Biological Interplay Between Genital HPV Infection and Cervicovaginal Microbiota in Sub-Saharan Africa: Implications for Cervical (Pre)cancer Prevention." Venereology 3, no. 4 (2024): 211–31. http://dx.doi.org/10.3390/venereology3040017.

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Cervical cancer is more common in Sub-Saharan Africa (SSA) compared to developed countries, with persistent genital high-risk HPV (HR-HPV) infection identified as the cause. However, other factors contributing to this gap remain unclear. This review explores the potential role of cervicovaginal microbiota (CVM) in genital HPV infection and cervical cancer development among women in SSA. Many women of African descent, including those from SSA, lack lactobacilli dominance in their CVM, which is considered a biomarker of cervicovaginal health. Published literature has associated Lactobacillus-dom
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Onywera, Harris, Anna-Lise Williamson, Zizipho Z. A. Mbulawa, David Coetzee, and Tracy L. Meiring. "Factors associated with the composition and diversity of the cervical microbiota of reproductive-age Black South African women: a retrospective cross-sectional study." PeerJ 7 (August 15, 2019): e7488. http://dx.doi.org/10.7717/peerj.7488.

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Background Lactobacillus spp. are common bacteria in the cervical and vaginal microbiota (CVM) and are thought to represent a “healthy” cervicovaginal state. Several studies have found an independent association between ethnicity/race and cervical and vaginal microbiota (CVM) composition. Women of sub-Saharan African descent appear to be significantly more likely to have non-Lactobacillus-dominated CVM compared to women of European descent. The factors contributing to these differences remain to be fully elucidated. The CVM of Black South African women and factors influencing their CVM remain
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Onywera, Harris, Joseph Anejo-Okopi, Lamech M. Mwapagha, Javan Okendo, and Anna-Lise Williamson. "Predictive functional analysis reveals inferred features unique to cervicovaginal microbiota of African women with bacterial vaginosis and high-risk human papillomavirus infection." PLOS ONE 16, no. 6 (2021): e0253218. http://dx.doi.org/10.1371/journal.pone.0253218.

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Mounting evidence suggests that Lactobacillus species may not necessarily be the sine qua non of healthy cervicovaginal microbiota (CVM), especially among reproductive-age African women. A majority of African women have high-diversity non-Lactobacillus-dominated CVM whose bacterial functions remain poorly characterized. Functional profiling of the CVM is vital for investigating human host-microbiota interactions in health and disease. Here, we investigated the functional potential of L. iners-dominated and high-diversity non-Lactobacillus-dominated CVM of 75 African women with and without bact
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Incognito, Giosuè Giordano, Carlo Ronsini, Vittorio Palmara, et al. "The Interplay Between Cervicovaginal Microbiota Diversity, Lactobacillus Profiles and Human Papillomavirus in Cervical Cancer: A Systematic Review." Healthcare 13, no. 6 (2025): 599. https://doi.org/10.3390/healthcare13060599.

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Background and Objectives: Interest in defining the characteristics of the cervicovaginal microbiota (CVM) in invasive cervical cancer (ICC) is growing, particularly concerning Lactobacillus species, as evidence suggests that these may differ in affected women and potentially interact with Human Papillomavirus (HPV) infection. Understanding these features could have important implications for disease management. Thus, this study aims to systematically review the main characteristics of available literature exploring the relationship between CVM diversity, Lactobacillus profiles, and HPV in ICC
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Yang, Zhongzhou, Ye Zhang, Araceli Stubbe-Espejel, et al. "Vaginal microbiota and personal risk factors associated with HPV status conversion—A new approach to reduce the risk of cervical cancer?" PLOS ONE 17, no. 8 (2022): e0270521. http://dx.doi.org/10.1371/journal.pone.0270521.

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Vaginal microbiota (VMB) is associated with changes in Human papilloma virus (HPV) status, which consequently influences the risk of cervical cancer. This association was often confounded by personal risk factors. This pilot research aimed to explore the relationship between vaginal microbiota, personal risk factors and their interactions with HPV status conversion to identify the vaginal microbiota that was associated with HPV clearance under heterogeneous personal risk factors. A total of 38 women participated by self-collecting a cervicovaginal mucus (CVM) sample that was sent for metagenom
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Dziurkovski Machado, Gabriel, Felipe Mota Narciso de Morais, Isabela Camilotti, Guilherme Prestes da Silva, Maria Regina Pinheiro de Andrade Tizzot, and Liya Regina Mikami. "DISBIOSE DA MICROBIOTA CERVICOVAGINAL NO DESENVOLVIMENTO DO CÂNCER DE COLO DE ÚTERO: UMA REVISÃO NARRATIVA." BioSCIENCE 80, no. 2 (2022): 29. http://dx.doi.org/10.55684/80.2.29.

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Racional: As relações ecológicas desempenhadas pela microbiota humana têm se mostrado relevantes no desenvolvimento de neoplasias, seja como fator de risco ou protetivo. A microbiota do aparelho genital feminino saudável é idealmente formada por poucos microrganismos do gênero Lactobacillus sp. Quando há disbiose, ocorre uma diminuição dessa população e colonização por diversas bactérias, cursando com patologias. A infecção persistente por alguns tipos do Papilomavírus Humano na microbiota vaginal é o principal fator de risco para o desenvolvimento de Câncer de Colo de Útero, que é a quarta ma
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Nguyen, Hong Duc Thi, Tan Minh Le, Eunmi Lee, et al. "Relationship between Human Papillomavirus Status and the Cervicovaginal Microbiome in Cervical Cancer." Microorganisms 11, no. 6 (2023): 1417. http://dx.doi.org/10.3390/microorganisms11061417.

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Uterine cervical cancer (CC) is a complex, multistep disease primarily linked to persistent infection with high-risk human papillomavirus (HR-HPV). However, it is widely acknowledged that HR-HPV infection alone cannot account for the formation and progression of CC. Emerging evidence suggests that the cervicovaginal microbiome (CVM) also plays a significant role in HPV-related CC. Certain bacteria, such as Fusobacterium spp., Porphyromonas, Prevotella, and Campylobacter, are currently being considered as potential microbiomarkers for HPV-positive CC. However, the composition of the CVM in CC i
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Cheu, Ryan K., Andrew T. Gustin, Christina Lee, et al. "Impact of vaginal microbiome communities on HIV antiretroviral-based pre-exposure prophylaxis (PrEP) drug metabolism." PLOS Pathogens 16, no. 12 (2020): e1009024. http://dx.doi.org/10.1371/journal.ppat.1009024.

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Despite the efficacy of antiretroviral-based pre-exposure prophylactics (PrEP) in men who have sex with men, studies in women have produced widely varying outcomes. Recent evidence demonstrates that vaginal microbial communities are associated with increased HIV acquisition risk and may impact PrEP efficacy. Here, we investigate the mechanisms underlying how vaginal bacteria alter PrEP drug levels and impact HIV infection rates ex vivo. Using cervicovaginal lavages (CVLs) from women with or without bacterial vaginosis (BV), we identified microbial metabolism of PrEP drugs in BV samples through
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Ivanov, Mikhail K., Evgeny V. Brenner, Anastasia A. Hodkevich, et al. "Cervicovaginal-Microbiome Analysis by 16S Sequencing and Real-Time PCR in Patients from Novosibirsk (Russia) with Cervical Lesions and Several Years after Cancer Treatment." Diagnostics 13, no. 1 (2023): 140. http://dx.doi.org/10.3390/diagnostics13010140.

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Disturbed cervicovaginal-microbiome (CVM) structure promotes human papillomavirus (HPV) persistence and reflects risks of cervical lesions and cancer onset and recurrence. Therefore, microbiomic biomarkers may be useful for cervical disease screening and patient management. Here, by 16S rRNA gene sequencing and commercial PCR-based diagnostic kits, we profiled CVM in cytological preparations from 140 HPV-tested women (from Novosibirsk, Russia) with normal cytological findings, cervical lesions, or cancer and from 101 women who had recently received different cancer therapies. An increase in le
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Dissertations / Theses on the topic "CVM (cervicovaginal microbiota)"

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Nicolo', Sabrina. "Interplay among microbial communities, epithelial cells, and immune system in vaginal mucosa of women with high-risk Human Papillomavirus infection." Doctoral thesis, 2022. http://hdl.handle.net/2158/1275958.

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Persistent infection with HR-HPVs is a primary cause of cervical cancer worldwide. Among HR-HPV, subtypes HPV-16 and HPV-18 are most associated with invasive cancers and are thought to cause approximately 65-75% of cases. Emerging evidence indicates that CVM plays a substantial role in the viral persistence and subsequent disease. Accordingly, a role of CVM composition in the regression of high grade of CIN lesions has been reported. Data from clinical studies show that Lactobacillus-dominated cervicovaginal microbiota and L. crispatus particularly was positively associated with the clearance
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Book chapters on the topic "CVM (cervicovaginal microbiota)"

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Werner De Oliveira, Julia, Helena Andrade de Freitas Lederer, Jéssica Lisbôa, and Bruna Passos Conti. "CARCINOMA DE COLO UTERINO E CORRELAÇÃO COM A MICROBIOTA CERVICOVAGINAL." In Ciência Brasileira: Múltiplos olhares - Medicina, Saúde e Prevenção Volume 02, 2nd ed. Even3 Publicações, 2023. http://dx.doi.org/10.29327/cb-medicina-saude-e-prevencao-2.599433.

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