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Relevant bibliographies by topics / CX546

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Academic literature on the topic 'CX546'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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Journal articles on the topic "CX546"

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Le, Alexander M., Michelle Lee, Chen Su, Anthony Zou, and Jing Wang. "AMPAkines Have Novel Analgesic Properties in Rat Models of Persistent Neuropathic and Inflammatory Pain." Anesthesiology 121, no. 5 (2014): 1080–90. http://dx.doi.org/10.1097/aln.0000000000000351.

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Abstract Background: Novel analgesics that do not suppress the respiratory drive are urgently needed. Glutamate signaling through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors plays important roles in central pain circuits. AMPAkines augment AMPA receptor function and have been shown to stimulate the respiratory drive to oppose opioid-induced hypoventilation. However, their role in chronic pain states remains unknown. Methods: The authors studied AMPAkines (CX546 and CX516) in rat spared nerve injury (SNI) model of neuropathic pain and Complete Freund’s Adjuvant (CFA) m

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Su, Chen, Hau Yeuh Lin, Runtao Yang, et al. "AMPAkines Target the Nucleus Accumbens to Relieve Postoperative Pain." Anesthesiology 125, no. 5 (2016): 1030–43. http://dx.doi.org/10.1097/aln.0000000000001336.

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Abstract Background AMPAkines augment the function of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the brain to increase excitatory outputs. These drugs are known to relieve persistent pain. However, their role in acute pain is unknown. Furthermore, a specific molecular and anatomic target for these novel analgesics remains elusive. Methods The authors studied the analgesic role of an AMPAkine, CX546, in a rat paw incision (PI) model of acute postoperative pain. The authors measured the effect of AMPAkines on sensory and depressive symptoms of pain using mechanical

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Zhou, W., N. Wang, C. Yang, X. M. Li, Z. Q. Zhou, and J. J. Yang. "Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex." European Psychiatry 29, no. 7 (2014): 419–23. http://dx.doi.org/10.1016/j.eurpsy.2013.10.005.

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AbstractKetamine exerts fast acting, robust, and lasting antidepressant effects in a sub-anesthetic dose, however, the underlying mechanisms are still not fully elucidated. Recent studies have suggested that ketamine's antidepressant effects are probably attributed to the activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. The present study aimed to observe the effects of AMPA receptor modulators on mammalian target of rapamycin (mTOR) and brain-derived neurotrophic factor (BDNF) expression during the procedure of ketamine exerting antidepressant effects. There

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Nagarajan, Naveen, Christoph Quast, Andrew R. Boxall, Mohammed Shahid, and Christian Rosenmund. "Mechanism and impact of allosteric AMPA receptor modulation by the AmpakineTM CX546." Neuropharmacology 41, no. 6 (2001): 650–63. http://dx.doi.org/10.1016/s0028-3908(01)00133-2.

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Schitine, Clarissa, Sara Xapelli, Fabienne Agasse, et al. "Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures." European Journal of Neuroscience 35, no. 11 (2012): 1672–83. http://dx.doi.org/10.1111/j.1460-9568.2012.08072.x.

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Lipina, Tatiana, Karin Weiss, and John Roder. "The Ampakine CX546 Restores the Prepulse Inhibition and Latent Inhibition Deficits in mGluR5-Deficient Mice." Neuropsychopharmacology 32, no. 4 (2006): 745–56. http://dx.doi.org/10.1038/sj.npp.1301191.

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Pellerin, Luc, and Pierre J. Magistretti. "Ampakine CX546 bolsters energetic response of astrocytes: A novel target for cognitive-enhancing drugs acting as AMPA receptor modulators." Journal of Cerebral Blood Flow & Metabolism 25, no. 1_suppl (2005): S70. http://dx.doi.org/10.1038/sj.jcbfm.9591524.0070.

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Hachem, LD, AJ Mothe, and CH Tator. "P.089 AMPA receptor modulation as a therapeutic strategy to enhance survival of spinal cord neural stem cells." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45, s2 (2018): S39—S40. http://dx.doi.org/10.1017/cjn.2018.191.

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Background: Transplantation of neural stem/progenitor cells (NSPCs) following spinal cord injury (SCI) is a promising strategy to enhance regeneration but is limited by poor survival of grafted cells. Recently, we demonstrated for the first time that the excitatory neurotransmitter glutamate, which is released after SCI, promotes survival/proliferation of spinal cord NSPCs via the AMPA subtype of glutamate receptors. Here, we examine the therapeutic potential of selective AMPA receptor modulation on NSPC survival using allosteric AMPA receptor modulators known as ampakines. Methods: NSPCs from

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Pellerin, Luc, and Pierre J. Magistretti. "Ampakinetm CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators." Journal of Neurochemistry 92, no. 3 (2005): 668–77. http://dx.doi.org/10.1111/j.1471-4159.2004.02905.x.

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Montgomery, Kyle E., Markus Kessler, and Amy C. Arai. "Modulation of Agonist Binding to AMPA Receptors by 1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine (CX546): Differential Effects across Brain Regions and GluA1–4/Transmembrane AMPA Receptor Regulatory Protein Combinations." Journal of Pharmacology and Experimental Therapeutics 331, no. 3 (2009): 965–74. http://dx.doi.org/10.1124/jpet.109.158014.

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Dissertations / Theses on the topic "CX546"

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Nagarajan, Naveen. "Molecular mechanisms of AMPA and kainate receptor gating and its implication in synaptic transmission." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965898768.

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Madgwick, Daniel. "Functional role of connexin 46 in lens epithelial cell differentiation and growth." Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/704.

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Tan, Xiao. "DISCOVERY OF SELECTIVE PROBES TARGETING RNA POLYMERASE I." UKnowledge, 2019. https://uknowledge.uky.edu/chemistry_etds/113.

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RNR Polymerase I (RNA Pol I) is a “factory” that orchestrate the transcription of ribosomal rRNA for constructing ribosomes as a primary workshop for protein translation to sustain cell growth. Misregulation of RNA Pol I can cause uncontrolled cell proliferation, which leads to the development of cancer. Yeast (Saccharomyces cerevisiae) is a valuable model system to study RNA Pol I. Recently, the X-ray crystal structure of the yeast homologue of RNA Pol I was elucidated, offering the structural basis to selectively target this transcriptional machinery. The approach to selective RNA Pol I targ

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Molina, Samuel A. "Functions of connexin 46 in lens and solid tumors during hypoxia." Diss., Kansas State University, 2012. http://hdl.handle.net/2097/13889.

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Doctor of Philosophy<br>Graduate Biochemistry Group<br>Dolores J. Takemoto<br>Eukaryotic cells possess a unique way to communicate with each other by passing metabolites and small molecules through protein pores that connect adjacent cells. Although there are many types and families of protein pores, connexins comprise a unique family. Six connexin monomers assemble into a hemichannel, which is transported to the cell membrane. An opposing cell membrane containing compatible connexin hemichannels is located and connected, forming an intercellular dodecameric protein complex. This results in a

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Chen, Pin-Te, and 陳品德. "Design and Implementation of High School Administration System." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/cxt546.

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碩士<br>國立臺北科技大學<br>電機工程系所<br>104<br>Since high school enrollment policy pluralism, including high schools, vocational education, comprehensive high school and training school. The same academic school administration needs usually more consistent and stable. The city government&;#39;s point of view, should be developmenting a shared city high school administration system. The schools can reduce purchase school administration system repeat, and avoid software vendors because fewer funds and discretion, reduce software quality and derived information security issues. This paper aims to develop a h

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Conference papers on the topic "CX546"

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Ismael, Mohammed, Roger Webb, Mazhur Ajaz, and Helen Coley. "Abstract 1862: CX5461 in combination with radiotherapy I effective against gynecological tumors." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1862.

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Sheppard, Karen E., Natalie Brajanovski, Katherine M. Hannan, et al. "Abstract 2718: Targeting ribosome biogenesis with CX5461 as a potential treatment for melanoma and ovarian cancer." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2718.

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