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Journal articles on the topic 'CXCR4 signalling'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Ray, Paramita, Sarah A. Lewin, Laura Anne Mihalko, et al. "Secreted CXCL12 (SDF-1) forms dimers under physiological conditions." Biochemical Journal 442, no. 2 (2012): 433–42. http://dx.doi.org/10.1042/bj20111341.

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Chemokine CXCL12 (CXC chemokine ligand 12) signalling through CXCR (CXC chemokine receptor) 4 and CXCR7 has essential functions in development and underlies diseases including cancer, atherosclerosis and autoimmunity. Chemokines may form homodimers that regulate receptor binding and signalling, but previous studies with synthetic CXCL12 have produced conflicting evidence for homodimerization. We used bioluminescence imaging with GL (Gaussia luciferase) fusions to investigate dimerization of CXCL12 secreted from mammalian cells. Using column chromatography and GL complementation, we established

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Gonzalez-Meljem, Jose Mario, Sarah Ivins, Cynthia Lilian Andoniadou, Paul Le Tissier, Peter Scambler, and Juan Pedro Martinez-Barbera. "An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development." PLOS ONE 18, no. 2 (2023): e0280001. http://dx.doi.org/10.1371/journal.pone.0280001.

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The chemokine SDF-1 (CXCL12) and its receptor CXCR4 control several processes during embryonic development such as the regulation of stem cell proliferation, differentiation, and migration. However, the role of this pathway in the formation of the pituitary gland is not understood. We sought to characterise the expression patterns of CXCR4, SDF-1 and CXCR7 at different stages of pituitary gland development. Our expression profiling revealed that SDF-1 is expressed in progenitor-rich regions of the pituitary anterior lobe, that CXCR4 and CXCR7 have opposite expression domains and that CXCR4 exp

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Friedman, Daniel, Antony Long, Piers EM Patten, and Robbert Hoogeboom. "Identification of a Novel Proliferating Cell Fraction in Chronic Lymphocytic Leukaemia with High Expression of IgM and Chemokine Receptors." Blood 138, Supplement 1 (2021): 3711. http://dx.doi.org/10.1182/blood-2021-153415.

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Abstract Chronic lymphocytic leukaemia (CLL) is characterised by the accumulation of malignant CD5+ B cells in the peripheral blood (PB), secondary lymphoid tissues and bone marrow. Currently considered an incurable disease, B cell receptor (BCR) signalling plays a key role in the disease aetiology as evidenced by the therapeutic success of BCR signalling inhibitors such as ibrutinib. Previous studies using incorporation of 2H-labelling of DNA in vivo demonstrated sub-clonal heterogeneity in PB CLL cell fractions sorted based on reciprocal densities of chemokine C-X-C motif receptor 4 (CXCR4)

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Barbieri, Federica, Stefano Thellung, Roberto Würth, et al. "Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System." International Journal of Endocrinology 2014 (2014): 1–16. http://dx.doi.org/10.1155/2014/753524.

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Chemokines are chemotactic regulators of immune surveillance in physiological and pathological conditions such as inflammation, infection, and cancer. Several chemokines and cognate receptors are constitutively expressed in the central nervous system, not only in glial and endothelial cells but also in neurons, controlling neurogenesis, neurite outgrowth, and axonal guidance during development. In particular, the chemokine CXCL12 and its receptors, CXCR4 and CXCR7, form a functional network that controls plasticity in different brain areas, influencing neurotransmission, neuromodulation, and c

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Weissleder, Christin, Maree J. Webster, and Cynthia Shannon Weickert. "M174. REDUCED CHEMOKINE SIGNALLING CAPACITY IS ASSOCIATED WITH INHIBITORY INTERNEURON DYSFUNCTION IN SUBCORTICAL BRAIN REGIONS IN SCHIZOPHRENIA AND BIPOLAR DISORDER." Schizophrenia Bulletin 46, Supplement_1 (2020): S202—S203. http://dx.doi.org/10.1093/schbul/sbaa030.486.

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Abstract Background The subependymal zone (SEZ) adjacent to the lateral ventricles represents the largest reservoir of postnatally-generated cortical and striatal inhibitory interneurons in the human brain. Expression of markers representing the generation of neuronal progenitors from neural stem cells is reduced in the adult SEZ in schizophrenia and bipolar disorder; however, underlying mechanisms and relationships to inhibitory interneuron dysfunction remain unknown. Stem cell maintenance, neuronal migration and cell survival are regulated by signaling of the CXC motif chemokine 12 (CXCL12)

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Nock, Sophie H., Maria R. Blanco-Lopez, Chloe Stephenson-Deakin, Sarah Jones, and Amanda J. Unsworth. "Pim Kinase Inhibition Disrupts CXCR4 Signalling in Megakaryocytes and Platelets by Reducing Receptor Availability at the Surface." International Journal of Molecular Sciences 25, no. 14 (2024): 7606. http://dx.doi.org/10.3390/ijms25147606.

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A key step in platelet production is the migration of megakaryocytes to the vascular sinusoids within the bone marrow. This homing is mediated by the chemokine CXCL12 and its receptor CXCR4. CXCR4 is also a positive regulator of platelet activation and thrombosis. Pim-1 kinase has been shown to regulate CXCR4 signalling in other cell types, and we have previously described how Pim kinase inhibitors attenuate platelet aggregation to CXCL12. However, the mechanism by which Pim-1 regulates CXCR4 signalling in platelets and megakaryocytes has yet to be elucidated. Using human platelets, murine bon

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Dalle Carbonare, Luca, Arianna Minoia, Anna Vareschi, et al. "Exploring the Interplay of RUNX2 and CXCR4 in Melanoma Progression." Cells 13, no. 5 (2024): 408. http://dx.doi.org/10.3390/cells13050408.

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Overexpression of the Runt-related transcription factor 2 (RUNX2) has been reported in several cancer types, and the C-X-C motif chemokine receptor 4 (CXCR4) has an important role in tumour progression. However, the interplay between CXCR4 and RUNX2 in melanoma cells remains poorly understood. In the present study, we used melanoma cells and a RUNX2 knockout (RUNX2-KO) in vitro model to assess the influence of RUNX2 on CXCR4 protein levels along with its effects on markers associated with cell invasion and autophagy. Osteotropism was assessed using a 3D microfluidic model. Moreover, we assesse

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Willett, Brian J., Karen Adema, Nikolaus Heveker, et al. "The Second Extracellular Loop of CXCR4 Determines Its Function as a Receptor for Feline Immunodeficiency Virus." Journal of Virology 72, no. 8 (1998): 6475–81. http://dx.doi.org/10.1128/jvi.72.8.6475-6481.1998.

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ABSTRACT The feline homolog of the α-chemokine receptor CXCR4 has recently been shown to support cell-cell fusion mediated by CXCR4-dependent strains of human immunodeficiency virus (HIV) and strains of feline immunodeficiency virus (FIV) that have been selected for growth in the Crandell feline kidney (CrFK) cell line. In this report we demonstrate that expression of CXCR4 alone is sufficient to render cells from diverse species permissive for fusion with FIV-infected cells, suggesting that CXCR4 is the sole receptor for CrFK-tropic strains of FIV, analogous to CD4-independent strains of HIV-

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Arvidsson, Yvonne, Anders Bergström, Linda Arvidsson, Erik Kristiansson, Håkan Ahlman, and Ola Nilsson. "Hypoxia stimulates CXCR4 signalling in ileal carcinoids." Endocrine-Related Cancer 17, no. 2 (2010): 303–16. http://dx.doi.org/10.1677/erc-09-0085.

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Tumour hypoxia is associated with increased metastatic potential and resistance to radiotherapy and chemotherapy. Ileal carcinoids are usually metastatic at the time of diagnosis and respond poorly to chemotherapy. The aim of this study was to investigate the extent of hypoxia in ileal carcinoids and the response of tumour cells to induced hypoxia. Vascular endothelial growth factor (VEGF), carbonic anhydrase (CA-IX), hypoxia-inducible factor (HIF)-1α and HIF-2α were studied by immunohistochemistry in biopsies from 24 patients with ileal carcinoids. All hypoxic markers were shown to be highly

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Murphy, Philip T., Brendan p. Power, Patrick D. Thornton, and Judith H. Harmey. "Regulation of B-Cell Chronic Lymphocytic Leukaemia Cell Survival and Migration by the VEGF/SEMA3A Axis." Blood 112, no. 11 (2008): 2083. http://dx.doi.org/10.1182/blood.v112.11.2083.2083.

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Abstract B-cell Chronic Lymphocytic Leukaemia (B-CLL) is characterized by the accumulation of B-CLL lymphocytes in the blood, marrow and secondary lymphoid tissues. B-CLL cells have a long survival owing to alterations in the normal pathways of apoptosis. In the marrow and lymphoid tissues CLL cells are in close contact with stromal cells that constitute distinct microenvironments. The secretion of the CXCR4 ligand, CXCL12, by stromal cells attracts B-CLL cells and provides protection from spontaneous or induced apoptosis. Studies in other cell types have shown VEGF signalling is involved in r

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Boujedidi, Hédia, Olivier Robert, Alexandre Bignon, et al. "CXCR4 dysfunction in non-alcoholic steatohepatitis in mice and patients." Clinical Science 128, no. 4 (2014): 257–67. http://dx.doi.org/10.1042/cs20130833.

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The CXCL12/CXCR4 signalling pathway contributes in both mice and patients to the enhanced recruitment of CD4+ T-cells in NASH. An increased affinity of the chemokine CXCL12 to its main receptor CXCR4 is involved in this process.

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Torossian, Frederic, Aurélie Chabanon, Denis Clay та ін. "CXCR7 Functions Together with CXCR4 in SDF-1/CXCL12 Induced CD34+ Hematopoietic Progenitor Cell Cycling Through β-Arrestin 2-Dependent Akt Activation". Blood 120, № 21 (2012): 3448. http://dx.doi.org/10.1182/blood.v120.21.3448.3448.

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Abstract Abstract 3448 Introduction SDF-1/CXCL12 chemokine exhibits a well-known effect on retention, migration and homing of hematopoietic stem/progenitor cells (HSC/HP). We have previously demonstrated that it is also a key regulator of hematopoiesis homeostasis, acting, at low concentrations, as a survival and cell cycle promoting factor for human CD34+ HP. It has long been considered that CXCR4 was responsible for SDF-1 induced biological effects until the recent discovery of its second receptor, CXCR7. In the present study, we explored the respective role of CXCR4 and CXCR7 in the cell cy

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Tiveron, Marie-Catherine, and Harold Cremer. "CXCL12/CXCR4 signalling in neuronal cell migration." Current Opinion in Neurobiology 18, no. 3 (2008): 237–44. http://dx.doi.org/10.1016/j.conb.2008.06.004.

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Wright, Kathryn, Kumudika de Silva, Karren M. Plain, et al. "Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis." PLOS Pathogens 17, no. 4 (2021): e1009186. http://dx.doi.org/10.1371/journal.ppat.1009186.

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Pathogenic mycobacteria actively dysregulate protective host immune signalling pathways during infection to drive the formation of permissive granuloma microenvironments. Dynamic regulation of host microRNA (miRNA) expression is a conserved feature of mycobacterial infections across host-pathogen pairings. Here we examine the role of miR-206 in the zebrafish model ofMycobacterium marinuminfection, which allows investigation of the early stages of granuloma formation. We find miR-206 is upregulated following infection by pathogenicM.marinumand that antagomir-mediated knockdown of miR-206 is pro

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del Molino del Barrio, Irene, Georgina Wilkins, Annette Meeson, Simi Ali, and John Kirby. "Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12." International Journal of Molecular Sciences 19, no. 11 (2018): 3592. http://dx.doi.org/10.3390/ijms19113592.

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Upon binding with the chemokine CXCL12, the chemokine receptor CXCR4 has been shown to promote breast cancer progression. This process, however, can be affected by the expression of the atypical chemokine receptor ACKR3. Given ACKR3’s ability to form heterodimers with CXCR4, we investigated how dual expression of both receptors differed from their lone expression in terms of their signalling pathways. We created single and double CXCR4 and/or ACKR3 Chinese hamster ovary (CHO) cell transfectants. ERK and Akt phosphorylation after CXCL12 stimulation was assessed and correlated with receptor inte

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Dong, Yonghui, Hui Liu, Xuejun Zhang та ін. "RETRACTED: Dong et al. Inhibition of SDF-1α/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis. Int. J. Mol. Sci. 2016, 17, 943". International Journal of Molecular Sciences 25, № 14 (2024): 7757. http://dx.doi.org/10.3390/ijms25147757.

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17

Li, Nan, Yingying Wang, Haoyu Xu, Hexi Wang, Yingying Gao та Yao Zhang. "Exosomes Derived from RM-1 Cells Promote the Recruitment of MDSCs into Tumor Microenvironment by Upregulating CXCR4 via TLR2/NF- κ B Pathway". Journal of Oncology 2021 (8 жовтня 2021): 1–9. http://dx.doi.org/10.1155/2021/5584406.

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Myeloid-derived suppressor cells (MDSCs) play a critical role in tumor immune escape because of its remarkable immunosuppressive effect. However, the mechanism of MDSCs migrated into tumor microenvironment remains unclear. In this study, we demonstrated the recruitment of MDSCs can be promoted by exosomes derived from prostate cancer cells, which could upregulate chemokine (CXC motif) receptor 4 (CXCR4) via the TLR2/NF- κ B signalling pathway. Flow cytometry detected that the percentage of MDSCs in the mice spleen and tumor tissue was significantly increased after injection with exosomes via m

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18

Ervin, J. M., S. Z. McIntosh, C. L. Runyan, and R. L. Ashley. "63 Inhibition of CXCR4 at the fetal-maternal interface during placentation results in altered production of vascular endothelial growth factor receptors in the placenta on Day 90 of pregnancy." Reproduction, Fertility and Development 32, no. 2 (2020): 157. http://dx.doi.org/10.1071/rdv32n2ab63.

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Placental development is characterised by extensive angiogenesis and vascularization; if these processes are compromised, placental dysfunction occurs, which is the underlying cause of complications such as preeclampsia and intrauterine growth restriction. The signalling axis initiated by chemokine ligand 12 (CXCL12) and its receptor CXCR4 stimulate angiogenesis critical to placental vascularization. Our laboratory and others demonstrated stimulation of vascular endothelial growth factor (VEGF) synthesis by CXCL12/CXCR4 signalling, and recently, we reported less production of the VEGF receptor

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Schrader, A. J., O. Lechner, M. Templin, et al. "CXCR4/CXCL12 expression and signalling in kidney cancer." British Journal of Cancer 86, no. 8 (2002): 1250–56. http://dx.doi.org/10.1038/sj.bjc.6600221.

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20

Kucia, Magda, Kacper Jankowski, Ryan Reca, et al. "CXCR4–SDF-1 Signalling, Locomotion, Chemotaxis and Adhesion." Journal of Molecular Histology 35, no. 3 (2003): 233–45. http://dx.doi.org/10.1023/b:hijo.0000032355.66152.b8.

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21

Zieker, D., I. Koenigsrainer, S. Beckert, et al. "Effect of changes in the glycolytic metabolism on tumor progression and dissemination in gastric cancer." Journal of Clinical Oncology 29, no. 4_suppl (2011): 47. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.47.

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47 Background: Metastases are a frequent finding in gastric cancer patients and are associated with a poor prognosis. Recent data indicate that there might be a link between metabolic changes in the glycolytic system and dissemination in gastric cancer. The enhanced expression of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1) and its signalling targets CXCR4 and CXCL12 seem to play a crucial role in enabling gastric tumours to develop dissemination. Methods: Microarray analysis was conducted investigating human specimens from consecutive gastric cancer patients with dissemination versu

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Sun, Zejia, Xin Li, Xiang Zheng, Peng Cao, Baozhong Yu, and Wei Wang. "Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation." Journal of International Medical Research 47, no. 11 (2019): 5426–40. http://dx.doi.org/10.1177/0300060519876138.

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Stem cell therapy has shown promise in treating a variety of pathologies, such as myocardial infarction, ischaemic stroke and organ transplantation. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) axis plays a key role in stem cell mobilization. This review describes the important role of SDF-1 in tissue injury and how it works in tissue revascularization and regeneration via CXCR4. Furthermore, factors influencing the SDF-1/CXCR4 axis and its clinical potential in ischaemia reperfusion injury, such as renal transplantation, are discussed. Exploring signalling pathwa

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Kim, Bo-Gyeong, Yong Hwan Kim, Edward L. Stanley, Eva María Garrido-Martin, Young Jae Lee, and S. Paul Oh. "CXCL12-CXCR4 signalling plays an essential role in proper patterning of aortic arch and pulmonary arteries." Cardiovascular Research 113, no. 13 (2017): 1677–87. https://doi.org/10.1093/cvr/cvx188.

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<strong>Aims: </strong>Chemokine CXCL12 (stromal derived factor 1: SDF1) has been shown to play important roles in various processes of cardiovascular development. In recent avian studies, CXCL12 signalling has been implicated in guidance of cardiac neural crest cells for their participation in the development of outflow tract and cardiac septum. The goal of this study is to investigate the extent to which CXCL12 signalling contribute to the development of aortic arch and pulmonary arteries in mammals. <strong>Methods and results: </strong>Novel Cxcl12-LacZ reporter and conditional a

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Terheyden-Keighley, Daniel, Xiaoqing Zhang, Beate Brand-Saberi, and Carsten Theiss. "CXCR4/SDF1 signalling promotes sensory neuron clustering in vitro." Biology Open 7, no. 9 (2018): bio035568. http://dx.doi.org/10.1242/bio.035568.

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Poltavets, Valentina, Jessica W. Faulkner, Deepak Dhatrak, Robert J. Whitfield, Shaun R. McColl, and Marina Kochetkova. "CXCR4-CCR7 Heterodimerization Is a Driver of Breast Cancer Progression." Life 11, no. 10 (2021): 1049. http://dx.doi.org/10.3390/life11101049.

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Metastatic breast cancer has one of the highest mortality rates among women in western society. Chemokine receptors CXCR4 and CCR7 have been shown to be linked to the metastatic spread of breast cancer, however, their precise function and underlying molecular pathways leading to the acquisition of the pro-metastatic properties remain poorly understood. We demonstrate here that the CXCR4 and CCR7 receptor ligands, CXCL12 and CCL19, cooperatively bind and selectively elicit synergistic signalling responses in invasive breast cancer cell lines as well as primary mammary human tumour cells. Furthe

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Wang, Jing, Tailang Yin, Yanqi Wen, et al. "Potential effects of interferon regulatory factor 4 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption." Reproduction, Fertility and Development 28, no. 10 (2016): 1631. http://dx.doi.org/10.1071/rd14499.

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Interferon regulatory factor (IRF) 4 has been reported to modulate Toll-like receptor (TLR) signalling. Polyinosinic-polycytidylic acid (poly(I:C)) can be specifically recognised by TLR3, triggering the innate immune response and subsequently resulting in pregnancy loss. In the present study, poly(I:C) was administered to mice with or without TLR3 blockade. Chemokine (C-X-C motif) receptor 4 (CXCR4) expression was measured with or without chemokine (C-X-C motif) ligand 12 (CXCL12) inhibition. In cultured murine splenic mononuclear cells, IRF4 was knocked down by a specific short interference (

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Zhao, Yaqian, Guanglan Pu, Yanan Li та ін. "Serum Levels of CXCR4, SDF-1, MCP-1, NF-κB and ERK1/2 in Patients with Skeletal Fluorosis". International Journal of Environmental Research and Public Health 19, № 24 (2022): 16555. http://dx.doi.org/10.3390/ijerph192416555.

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C-X-C motif chemokine receptor 4 (CXCR4), stromal cell-derived factor-1 (SDF-1), monocyte chemoattractant protein-1 (MCP-1), extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor-κB (NF-κB) affect bone cells and play an important role in bone and joint diseases, but the data on CXCR4, SDF-1, MCP-1, ERK1/2 and NF-κB in the serum of skeletal fluorosis (SF) patients are inconclusive. Thus, according to the “Diagnostic Criteria for Endemic Skeletal Fluorosis” (WS 192 - 2008), we enrolled patients with SF (n = 60) as the SF group and those without SF as the controls (n = 60). Serum

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Borna, Simon, Ales Drobek, Jarmila Kralova, et al. "Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis." Journal of Cellular and Molecular Medicine 24, no. 2 (2019): 1980–92. http://dx.doi.org/10.1111/jcmm.14895.

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Pritchett, J., C. Wright, L. Zeef, and B. Nadarajah. "[P140]: Sdf‐1/Cxcr4 signalling regulates proliferation during cortical development." International Journal of Developmental Neuroscience 24, no. 8 (2006): 556. http://dx.doi.org/10.1016/j.ijdevneu.2006.09.202.

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Ma, M., and G. C. F. Chan. "Mesenchymal Stem Cells Enhanced Metastasis of Neuroblastoma Via SDF-1/CXCR4 and SDF-1/CXCR7 Signalling." Biology of Blood and Marrow Transplantation 18, no. 2 (2012): S374—S375. http://dx.doi.org/10.1016/j.bbmt.2011.12.459.

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Bouamar, Hakim, Yanyan Zhang, Dima Jouni, et al. "CXCR7 Expression Restricts CXCR4/SDF-1 Mediated Hematopoietic-Supporting Activity of Stromal Cells by Decreasing Extracellular SDF-1 Availability." Blood 114, no. 22 (2009): 1452. http://dx.doi.org/10.1182/blood.v114.22.1452.1452.

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Abstract Abstract 1452 Poster Board I-475 Stromal cell-derived factor 1 (SDF-1)/CXCR4 axis plays a major role in regulating the interactions between hematopoietic stem and progenitor cells (HPSC) and their stromal microenvironment within the bone marrow. A second SDF-1/CXCL12 receptor, CXCR7 binds SDF-1 with high affinity but little is known about its function in hematopoiesis. In the present study, we demonstrate that the activity of CXCR7 is crucial for proper maintenance of hematopoietic activity on stromal layers. Using quantitative reverse transcription-PCR analysis, we demonstrate that C

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Simon, Anna, Dagmar Wider, Marie Follo, et al. "Targeting The Protective Microenvironment In Multiple Myeloma (MM): An Analysis Of The CXCL12/CXCR4-Axis and Its Inhibitors AMD3100 and Nox-A12 Combined With Antimyeloma Substances, Such As Pomalidomide and Carfilzomib." Blood 122, no. 21 (2013): 3851. http://dx.doi.org/10.1182/blood.v122.21.3851.3851.

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Abstract Introduction The interaction of malignant plasma cells (PC) with the bone marrow (BM) microenvironment is crucial for MM pathogenesis. The CXCL12/CXCR4-axis plays a key role in this cross-talk.CXCL12 induces homing of normal hematopoietic progenitor cells to the BM and also drives MM cells to their protective niche. The binding of CXCL12 to CXCR4 directly promotes PC survival and facilitates environment-mediated drug resistance, which ultimately renders antimyeloma substances ineffective. Therefore, targeting the CXCL12/CXCR4-axis in combination with the use of new antimyeloma therape

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De Toni, L., A. Di Nisio, S. Magagna, et al. "Altered Chemokine Signalling in Endothelial Progenitor Cells from Acute Ulcerative Colitis Patients." Gastroenterology Research and Practice 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/843980.

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Ulcerative colitis (UC) is a chronic, idiopathic, inflammatory bowel disease, characterized by alternating stages of clinically active and inactive disease. UC exhibits several inflammatory characteristics, including immune activation, leukocyte infiltration, and altered vascular density. In UC, many of the upregulated inflammatory cytokines are proangiogenic and are released by diverse cell populations, such as infiltrating immune cells and endothelial cells (EC). Increasing evidences suggest that neovascularisation may involve also endothelial progenitor cells (EPCs). In this study we evalua

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Foresta, Carlo, Luca De Toni, Sabina Magagna, Alessandro Galan, and Andrea Garolla. "Phosphodiesterase-5 Inhibitor Tadalafil Acts on Endothelial Progenitor Cells by CXCR4 Signalling." Current Drug Delivery 7, no. 4 (2010): 274–82. http://dx.doi.org/10.2174/156720110793360595.

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Verma, Anant, Ganapathy Ayappa, and Deepak K. Saini. "Understanding the loss of CXCR4-mediated signalling in the presence of oxysterols." Biophysical Journal 121, no. 3 (2022): 194a. http://dx.doi.org/10.1016/j.bpj.2021.11.1762.

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Pastore, Domenico, Anna Mestice, Margherita Giannoccaro, et al. "CXCR4 as a Predictor of Response in Acute Myeloid Leukemia." Blood 112, no. 11 (2008): 2941. http://dx.doi.org/10.1182/blood.v112.11.2941.2941.

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Abstract The expression of CXCR4 (CD184) has been associated with poor prognosis in Acute Myeloid Leukemia (AML) and it has also been suggested that the CXCL12(SDF-1a)/CXCR4 interaction contributes to the resistance of leukemia cells to chemotherapy-induced apoptosis. Inhibition of CXCR4 was found to enhance chemotherapy-induced apoptosis in a subset of leukemic myeloblasts that carry Flt3 mutations and to overcome chemoresistance associated with stromal activity. NPM variants with a cytoplasmic localization represent the most common mutation detected in myeloid malignancies and are associated

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Vitale, Candida, Valentina Griggio, Chiara Riganti та ін. "Targeting HIF-1α Regulatory Pathways as a Strategy to Hamper Tumor-Microenvironment Interactions in CLL". Cancers 13, № 12 (2021): 2883. http://dx.doi.org/10.3390/cancers13122883.

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The hypoxia-inducible factor 1 (HIF-1) and the CXCL12/CXCR4 axis regulate the interaction of chronic lymphocytic leukemia cells and the tumor microenvironment. However, the interconnections occurring between HIF-1 and the CXCL12/CXCR4 axis are not fully elucidated. Here, we demonstrate that the CXCL12/CXCR4 axis plays a pivotal role in the positive regulation of the α subunit of HIF-1 (HIF-1α) that occurs in CLL cells co-cultured with stromal cells (SC). Inhibitors acting at different levels on CXCR4 downstream signalling counteract the SC-induced HIF-1α upregulation in CLL cells, also hinderi

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Bendall, Linda, Rana Baraz, Julius Juarez, Sylvie Shen, and Ken Bradstock. "Defective P38 MAPK Signalling Impairs Chemotactic but Not Proliferative Responses to SDF-1 in Acute Lymphoblastic Leukemia." Blood 104, no. 11 (2004): 997. http://dx.doi.org/10.1182/blood.v104.11.997.997.

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Abstract The chemokine SDF-1 regulates leukemic cell motility and proliferation but the importance of these functions in the growth and dissemination of leukemia is unclear. We examined SDF-1-mediated responses of cells from 27 cases of acute lymphoblastic leukemia (ALL). Although cells from the majority of cases showed chemotactic and proliferative responses to SDF-1, a subset of cases (18%) did not undergo chemotaxis in response to SDF-1 (unresponsive cases). These unresponsive cases also failed to increase b1 integrin-mediated adhesion to fibronectin or adhesion to bone marrow fibroblast la

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Khatun, Hazera, Amna Anwar, Majid A. Kazmi, Stephen Schey, and Yolanda Calle. "The Wiskott Aldrich Syndrome Protein (WASP) Is Involved in Dexamethasone-Signalling Pathways Leading to Apoptosis of Multiple Myeloma Cells and in Cell Adhesion Mediated Drug Resistance Against Dexamethasone." Blood 118, no. 21 (2011): 1809. http://dx.doi.org/10.1182/blood.v118.21.1809.1809.

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Abstract Abstract 1809 Direct contact of multiple myeloma (MM) cells with the bone marrow (BM) stroma promotes cell survival leading to cell adhesion mediated drug resistance (CAM-DR). Dexamethasone is a conventional anti-MM drug that effectively induces MM cell death at presentation and in relapsed patients but the signalling pathways involved in its mechanisms of action are not completely understood. Resistance of MM to Dexamethasone may result from genetic changes in MM cells or through the contact of MM cells with the BM microenvironment. It has been shown that CAM-DR blocks the effect of

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Kovtonyuk, Larisa V., Markus G. Manz, and Hitoshi Takizawa. "Thrombopoietin-Receptor Signalling Induces Proliferation of Dormant HSC." Blood 120, no. 21 (2012): 2343. http://dx.doi.org/10.1182/blood.v120.21.2343.2343.

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Abstract Abstract 2343 Lifelong blood production is maintained by a very rare population of self-renewing hematopoietic stem cells (HSCs) in bone marrow (BM). Proliferation, differentiation and survival of HSC toward stepwise hematopoietic cell development needs to be tightly controlled by cell intrinsic and extrinsic factors, as excess or insufficient production of mature blood cells potentially leads to neoplasia or aplasia. HSCs and progenitors (HSPCs) are equipped with cell surface receptors for different cytokines or chemokines (Kaushansky, NEJM 2006), and thus can integrate external sign

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Fiegl, Michael, Ismael J. Samudio, Karen Clise Dwyer, et al. "CXCR4 Expression and Biological Activity Is Dependent on Oxygen Partial Pressure in Acute Myeloid Leukemia." Blood 112, no. 11 (2008): 938. http://dx.doi.org/10.1182/blood.v112.11.938.938.

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Abstract CXCR4, the receptor for bone marrow stroma derived SDF-1, has recently been studied in normal hematopoiesis and hematologic malignancies. Increased expression of CXCR4 by leukemic blasts has been reported by us and others (Konoplev S. et al, Cancer 2007) to be associated with poor prognosis in acute myeloid leukemia (AML). However, all in-vitro studies are usually carried out under unphysiological, i.e. normoxic (21% O2) conditions. We hypothesized that the pO2 in vitro has major impact on the expression of CXCR4, a key receptor for cell migration and intracellular signalling. Thus, p

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Vitale, Candida, Valentina Griggio, Chiara Riganti, et al. "The Mevalonate Metabolic Pathway and the CXCL12/CXCR4 Axis Reciprocally Interact and Are Implicated in Fludarabine Resistance of Chronic Lymphocytic Leukemia Cells." Blood 124, no. 21 (2014): 833. http://dx.doi.org/10.1182/blood.v124.21.833.833.

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Abstract BACKGROUND: Treatment of fludarabine-resistant chronic lymphocytic leukemia (CLL) patients is an unmet clinical need. Fludarabine resistance in CLL depends on intrinsic molecular features of the tumor cells, and on bidirectional interactions occurring between CLL cells and stromal cells (SC) of the tumor microenvironment. One of the main players of SC-induced fludarabine resistance is the CXCL12/CXCR4 axis. CXCR4 is a G protein-coupled receptor constitutively expressed on CLL cells. The binding of CXCR4 with CXCL12 activates the Ras/ERK1-2/Akt and the RhoA-dependent signalling pathway

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Kulkarni, Tanmay, Shamit Dutta, Hazel Parent, Karington Perry, Yuri Mackeyev, and Santanu Bhattacharya. "Abstract 3181: Immune modulatory activity of radio-sensitizing gold nanoparticle." Cancer Research 84, no. 6_Supplement (2024): 3181. http://dx.doi.org/10.1158/1538-7445.am2024-3181.

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Abstract Radiation therapy (RT) is frequently used in the neoadjuvant setting in borderline resectable and some resectable pancreatic ductal adenocarcinoma (PDAC) and in the definitive setting in locally advanced PDACs which is third leading cause of cancer associated death. Higher doses of RT improve overall treatment outcomes but increasing the dose significantly above 50Gy in standard 2Gy fractions risks profound gastrointestinal (GI) toxicity. Additionally, genotoxic stress such as RT, can induce CXCL12 secretion by cancer associated fibroblast (CAFs) and overexpression of CXC motif chemok

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Dong, Yonghui, Hui Liu, Xuejun Zhang та ін. "Inhibition of SDF-1α/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis". International Journal of Molecular Sciences 17, № 6 (2016): 943. http://dx.doi.org/10.3390/ijms17060943.

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Selvaraj, P., D. He, C. Boi-Doku та ін. "253 REMOTE ISCHAEMIC PRECONDITIONING IS MEDIATED VIA THE SDF 1Α/CXCR4 SIGNALLING AXIS". Heart 99, suppl 2 (2013): A134.1—A134. http://dx.doi.org/10.1136/heartjnl-2013-304019.253.

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Verdelli, C., L. Avagliano, P. Creo, et al. "Tumour-associated fibroblasts contribute to neoangiogenesis in human parathyroid neoplasia." Endocrine-Related Cancer 22, no. 1 (2014): 87–98. http://dx.doi.org/10.1530/erc-14-0161.

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Components of the tumour microenvironment initiate and promote cancer development. In this study, we investigated the stromal component of parathyroid neoplasia. Immunohistochemistry for alpha-smooth muscle actin (α-SMA) showed an abundant periacinar distribution of α-SMA+ cells in normal parathyroid glands (n=3). This pattern was progressively lost in parathyroid adenomas (PAds; n=6) where α-SMA+cells were found to surround new microvessels, as observed in foetal parathyroid glands (n=2). Moreover, in atypical adenomas (n=5) and carcinomas (n=4), α-SMA+ cells disappeared from the parenchyma a

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Hart, Derek, Courtney Modra, and Georgina Clark. "CD300f Triggering Modifies Myeloid Cell Function." Blood 112, no. 11 (2008): 1255. http://dx.doi.org/10.1182/blood.v112.11.1255.1255.

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Abstract CD300f, a member of the CD300 family of immunoregulatory molecules, is capable of signalling through association with both SHP-1 phosphatase and the p85α subunit of phosphoinositide 3-kinase. On normal cells, CD300f is expressed on monocytes and dendritic cells in the blood and bone marrow. CD300f is expressed on myeloid derived cell lines and Acute Myeloid Leukaemias (AMLs) and is an acknowledged candidate for antibody targeting of AML (Modra CJ et al. Blood2006;108:225B-225B and Zhao X et al Blood2007;110:531a–532a). We have generated a monoclonal antibody, MMRI- 23, specific for th

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Vlad, Amalia, Pierre-Antoine Deglesne, Remi Letestu, et al. "CXCR4 and CD62L Down-Regulation Following B-Cell Receptor Ligation Is Restricted to Progressive Chronic Lymphocytic Leukemia (CLL) Cases." Blood 110, no. 11 (2007): 1122. http://dx.doi.org/10.1182/blood.v110.11.1122.1122.

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Abstract B cell receptor (BCR) mediated survival plays a central role in disease progression of CLL. We have previously shown that BCR engagement allowed the identification of two groups of patients with a strong correlation between in vitro cell survival response capacity and clinical stage or prognostic factors. The aim of this study was to determine the implication of BCR stimulation in the accumulation of CLL cells in the enlarged lymph nodes of progressive cases. Therefore, we investigated the in vitro migratory capacity of CLL cells and the level of expression of microenvironment interac

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Cuthill, Kirsty, Yan Zhang, Andrea Buggins, et al. "In-Vivo Labelling Studies in Patients with Chronic Lymphocytic Leukemia Studies Demonstrate the Existence of Apparently Distinct Subpopulations That Differ in Phenotype and Proliferative Capacity." Blood 126, no. 23 (2015): 615. http://dx.doi.org/10.1182/blood.v126.23.615.615.

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Abstract It is now generally believed that proliferation of the neoplastic clone in chronic lymphocytic leukemia (CLL) takes place in lymphoid tissues where interactions involving the B-cell receptor (BCR) and other microenvironmental elements take place. Previous studies using in-vivo labelling with deuterated water have shown that recently proliferated emigrants from lymphoid tissues express low levels of the chemokine receptor CXCR4 and high levels of CD5 (CXCR4loCD5hi). It has been proposed that, following entry into the peripheral blood (PB), these cells become quiescent, re-express CXCR4

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Wang, Rongrong, Jiaming Qian, Da Ji, Xingyu Liu, and Ranran Dong. "Transcriptome Analysis Reveals Effect of Dietary Probiotics on Immune Response Mechanism in Southern Catfish (Silurus meridionalis) in Response to Plesiomonas shigelloides." Animals 13, no. 3 (2023): 449. http://dx.doi.org/10.3390/ani13030449.

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To explore whether a probiotic complex composed of Lactobacillus rhamnosus, Lactobacillus plantarum, and Lactobacillus casei can prevent or inhibit the inflammatory response caused by the invasion of Plesiomonas shigelloides in the southern catfish, we screened differentially expressed genes and enriched inflammation-related pathways among a control and three experimental groups and conducted analysis by transcriptome sequencing after a 21-day breeding experiment. Compared with those in the PS (Plesiomonas shigelloides) group, southern catfish in the L-PS (Lactobacillus-Plesiomonas shigelloide

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