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Journal articles on the topic 'Cyanobacteria Toxicology'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 January 2023

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1

Rangel, Luciana M., Lúcia H. S. Silva, Elisabeth J. Faassen, Miquel Lürling, and Kemal Ali Ger. "Copepod Prey Selection and Grazing Efficiency Mediated by Chemical and Morphological Defensive Traits of Cyanobacteria." Toxins 12, no. 7 (July 21, 2020): 465. http://dx.doi.org/10.3390/toxins12070465.

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Phytoplankton anti-grazer traits control zooplankton grazing and are associated with harmful blooms. Yet, how morphological versus chemical phytoplankton defenses regulate zooplankton grazing is poorly understood. We compared zooplankton grazing and prey selection by contrasting morphological (filament length: short vs. long) and chemical (saxitoxin: STX- vs. STX+) traits of a bloom-forming cyanobacterium (Raphidiopsis) offered at different concentrations in mixed diets with an edible phytoplankton to a copepod grazer. The copepod selectively grazed on the edible prey (avoidance of cyanobacter

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2

Andeden, Enver Ersoy, Sahlan Ozturk, and Belma Aslim. "Antiproliferative, neurotoxic, genotoxic and mutagenic effects of toxic cyanobacterial extracts." Interdisciplinary Toxicology 11, no. 4 (December 1, 2018): 267–74. http://dx.doi.org/10.2478/intox-2018-0026.

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Abstract Cyanobacteria are the rich resource of various secondary metabolites including toxins with broad pharmaceutical significance. The aim of this work was to evaluate the antiproliferative, neurotoxic, genotoxic and mutagenic effects of cyanobacterial extracts containing Microcystin-LR (MCLR) in vitro. ELISA analysis results showed that MCLR contents of five cyanobacterial extracts were 2.07 ng/mL, 1.43 ng/mL, 1.41 ng/mL, 1.27 ng/mL, and 1.12 ng/mL for Leptolyngbya sp. SB1, Phormidium sp. SB4, Oscillatoria earlei SB5, Phormidium sp. SB2, Uncultured cyanobacterium, respectively. Phormidium

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Jalili, Farhad, Saber Moradinejad, Arash Zamyadi, Sarah Dorner, Sébastien Sauvé, and Michèle Prévost. "Evidence-Based Framework to Manage Cyanobacteria and Cyanotoxins in Water and Sludge from Drinking Water Treatment Plants." Toxins 14, no. 6 (June 15, 2022): 410. http://dx.doi.org/10.3390/toxins14060410.

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Freshwater bodies and, consequently, drinking water treatment plants (DWTPs) sources are increasingly facing toxic cyanobacterial blooms. Even though conventional treatment processes including coagulation, flocculation, sedimentation, and filtration can control cyanobacteria and cell-bound cyanotoxins, these processes may encounter challenges such as inefficient removal of dissolved metabolites and cyanobacterial cell breakthrough. Furthermore, conventional treatment processes may lead to the accumulation of cyanobacteria cells and cyanotoxins in sludge. Pre-oxidation can enhance coagulation e

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4

Dulić, Tamara, Zorica Svirčev, Tamara Palanački Malešević, Elisabeth J. Faassen, Henna Savela, Qingzhen Hao, and Jussi Meriluoto. "Assessment of Common Cyanotoxins in Cyanobacteria of Biological Loess Crusts." Toxins 14, no. 3 (March 16, 2022): 215. http://dx.doi.org/10.3390/toxins14030215.

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Cyanotoxins are a diverse group of bioactive compounds produced by cyanobacteria that have adverse effects on human and animal health. While the phenomenon of cyanotoxin production in aquatic environments is well studied, research on cyanotoxins in terrestrial environments, where cyanobacteria abundantly occur in biocrusts, is still in its infancy. Here, we investigated the potential cyanotoxin production in cyanobacteria-dominated biological loess crusts (BLCs) from three different regions (China, Iran, and Serbia) and in cyanobacterial cultures isolated from the BLCs. The presence of cyanoto

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Swartzendruber, Julie A., Rosalinda Monroy Del Toro, Ryan Incrocci, Nessa Seangmany, Joshua R. Gurr, Alejandro M. S. Mayer, Philip G. Williams, and Michelle Swanson-Mungerson. "Lipopolysaccharide from the Cyanobacterium Geitlerinema sp. Induces Neutrophil Infiltration and Lung Inflammation." Toxins 14, no. 4 (April 9, 2022): 267. http://dx.doi.org/10.3390/toxins14040267.

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Glucocorticoid-resistant asthma, which predominates with neutrophils instead of eosinophils, is an increasing health concern. One potential source for the induction of neutrophil-predominant asthma is aerosolized lipopolysaccharide (LPS). Cyanobacteria have recently caused significant tidal blooms, and aerosolized cyanobacterial LPS has been detected near the cyanobacterial overgrowth. We hypothesized that cyanobacterial LPS contributes to lung inflammation by increasing factors that promote lung inflammation and neutrophil recruitment. To test this hypothesis, c57Bl/6 mice were exposed intran

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6

Liyanage, H. M., D. N. Magana Arachchi, T. Abeysekara, and L. Guneratne. "Toxicology of freshwater cyanobacteria." Journal of Environmental Science and Health, Part C 34, no. 3 (May 26, 2016): 137–68. http://dx.doi.org/10.1080/10590501.2016.1193923.

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Ballot, Andreas, Thida Swe, Marit Mjelde, Leonardo Cerasino, Vladyslava Hostyeva, and Christopher O. Miles. "Cylindrospermopsin- and Deoxycylindrospermopsin-Producing Raphidiopsis raciborskii and Microcystin-Producing Microcystis spp. in Meiktila Lake, Myanmar." Toxins 12, no. 4 (April 7, 2020): 232. http://dx.doi.org/10.3390/toxins12040232.

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Meiktila Lake is a shallow reservoir located close to Meiktila city in central Myanmar. Its water is used for irrigation, domestic purposes and drinking water. No detailed study of the presence of cyanobacteria and their potential toxin production has been conducted so far. To ascertain the cyanobacterial composition and presence of cyanobacterial toxins in Meiktila Lake, water samples were collected in March and November 2017 and investigated for physico-chemical and biological parameters. Phytoplankton composition and biomass determination revealed that most of the samples were dominated by

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8

Schwarzenberger, Anke. "Negative Effects of Cyanotoxins and Adaptative Responses of Daphnia." Toxins 14, no. 11 (November 7, 2022): 770. http://dx.doi.org/10.3390/toxins14110770.

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The plethora of cyanobacterial toxins are an enormous threat to whole ecosystems and humans. Due to eutrophication and increases in lake temperatures from global warming, changes in the distribution of cyanobacterial toxins and selection of few highly toxic species/ strains are likely. Globally, one of the most important grazers that controls cyanobacterial blooms is Daphnia, a freshwater model organism in ecology and (eco)toxicology. Daphnia–cyanobacteria interactions have been studied extensively, often focusing on the interference of filamentous cyanobacteria with Daphnia’s filtering appara

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Dziga, Dariusz, Nada Tokodi, Damjana Drobac, Mikołaj Kokociński, Adam Antosiak, Jakub Puchalski, Wojciech Strzałka, Mariusz Madej, Zorica Svirčev, and Jussi Meriluoto. "The Effect of a Combined Hydrogen Peroxide-MlrA Treatment on the Phytoplankton Community and Microcystin Concentrations in a Mesocosm Experiment in Lake Ludoš." Toxins 11, no. 12 (December 11, 2019): 725. http://dx.doi.org/10.3390/toxins11120725.

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Harmful cyanobacteria and their toxic metabolites constitute a big challenge for the production of safe drinking water. Microcystins (MC), chemically stable hepatotoxic heptapeptides, have often been involved in cyanobacterial poisoning incidents. A desirable solution for cyanobacterial management in lakes and ponds would eliminate both excess cyanobacteria and the MC that they potentially produce and release upon lysis. Hydrogen peroxide (H2O2) has recently been advocated as an efficient means of lysing cyanobacteria in lakes and ponds, however H2O2 (at least when used at typical concentratio

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Khomutovska, Nataliia, Małgorzata Sandzewicz, Łukasz Łach, Małgorzata Suska-Malawska, Monika Chmielewska, Hanna Mazur-Marzec, Marta Cegłowska, et al. "Limited Microcystin, Anatoxin and Cylindrospermopsin Production by Cyanobacteria from Microbial Mats in Cold Deserts." Toxins 12, no. 4 (April 11, 2020): 244. http://dx.doi.org/10.3390/toxins12040244.

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Toxic metabolites are produced by many cyanobacterial species. There are limited data on toxigenic benthic, mat-forming cyanobacteria, and information on toxic cyanobacteria from Central Asia is even more scarce. In the present study, we examined cyanobacterial diversity and community structure, the presence of genes involved in toxin production and the occurrence of cyanotoxins in cyanobacterial mats from small water bodies in a cold high-mountain desert of Eastern Pamir. Diversity was explored using amplicon-based sequencing targeting the V3-V4 region of the 16S rRNA gene, toxin potential us

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Popova, Alexandra, Tatiana Semashko, Natalia Kostina, Ulla Rasmussen, Vadim Govorun, and Olga Koksharova. "The Cyanotoxin BMAA Induces Heterocyst Specific Gene Expression in Anabaena sp. PCC 7120 under Repressive Conditions." Toxins 10, no. 11 (November 16, 2018): 478. http://dx.doi.org/10.3390/toxins10110478.

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Cyanobacteria synthesize neurotoxic β-N-methylamino-l-alanine (BMAA). The roles of this non-protein amino acid in cyanobacterial cells are insufficiently studied. During diazotrophic growth, filamentous cyanobacteria form single differentiated cells, called heterocysts, which are separated by approximately 12–15 vegetative cells. When combined nitrogen is available, heterocyst formation is blocked and cyanobacterial filaments contain only vegetative cells. In the present study, we discovered that exogenous BMAA induces the process of heterocyst formation in filamentous cyanobacteria under nitr

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Duchnik, Kornelia, Jan Bialczyk, Ewelina Chrapusta-Srebrny, and Beata Bober. "Inhibition of growth rate and cylindrospermopsin synthesis by Raphidiopsis raciborskii upon exposure to macrophyte Lemna trisulca (L)." Ecotoxicology 30, no. 3 (March 12, 2021): 470–77. http://dx.doi.org/10.1007/s10646-021-02377-7.

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AbstractImpact of macrophyte Lemna trisulca on the growth rate and synthesis of cylindrospermopsin (CYN) by cyanobacterium Raphidiopsis raciborskii was determined. The presence of L. trisulca inhibited the biomass accumulation of the cyanobacterium by 25% compared to the control during co-cultivation. The simultaneous cultivation of these organisms slightly affected the inhibition of macrophyte growth rate by 5.5% compared to the control. However, no morphological changes of L. trisulca after incubation with cyanobacteria were observed. It was also shown that the long-term (35 days) co-cultiva

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El Amrani Zerrifi, Soukaina, Fatima El Khalloufi, Richard Mugani, Redouane El Mahdi, Ayoub Kasrati, Bouchra Soulaimani, Lillian Barros, et al. "Seaweed Essential Oils as a New Source of Bioactive Compounds for Cyanobacteria Growth Control: Innovative Ecological Biocontrol Approach." Toxins 12, no. 8 (August 17, 2020): 527. http://dx.doi.org/10.3390/toxins12080527.

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The application of natural compounds extracted from seaweeds is a promising eco-friendly alternative solution for harmful algae control in aquatic ecosystems. In the present study, the anti-cyanobacterial activity of three Moroccan marine macroalgae essential oils (EOs) was tested and evaluated on unicellular Microcystis aeruginosa cyanobacterium. Additionally, the possible anti-cyanobacterial response mechanisms were investigated by analyzing the antioxidant enzyme activities of M. aeruginosa cells. The results of EOs GC–MS analyses revealed a complex chemical composition, allowing the identi

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Shishido, Tania Keiko, Rafael Vicentini Popin, Jouni Jokela, Matti Wahlsten, Marli Fatima Fiore, David P. Fewer, Lars Herfindal, and Kaarina Sivonen. "Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria." Toxins 12, no. 1 (December 24, 2019): 12. http://dx.doi.org/10.3390/toxins12010012.

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Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these e

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15

Mucci, Maíra, Iame A. Guedes, Elisabeth J. Faassen, and Miquel Lürling. "Chitosan as a Coagulant to Remove Cyanobacteria Can Cause Microcystin Release." Toxins 12, no. 11 (November 10, 2020): 711. http://dx.doi.org/10.3390/toxins12110711.

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Chitosan has been tested as a coagulant to remove cyanobacterial nuisance. While its coagulation efficiency is well studied, little is known about its effect on the viability of the cyanobacterial cells. This study aimed to test eight strains of the most frequent bloom-forming cyanobacterium, Microcystis aeruginosa, exposed to a realistic concentration range of chitosan used in lake restoration management (0 to 8 mg chitosan L−1). We found that after 1 h of contact with chitosan, in seven of the eight strains tested, photosystem II efficiency was decreased, and after 24 h, all the strains test

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Oliveira, Flavio, Leticia Diez-Quijada, Maria V. Turkina, João Morais, Aldo Barreiro Felpeto, Joana Azevedo, Angeles Jos, et al. "Physiological and Metabolic Responses of Marine Mussels Exposed to Toxic Cyanobacteria Microcystis aeruginosa and Chrysosporum ovalisporum." Toxins 12, no. 3 (March 20, 2020): 196. http://dx.doi.org/10.3390/toxins12030196.

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Toxic cyanobacterial blooms are a major contaminant in inland aquatic ecosystems. Furthermore, toxic blooms are carried downstream by rivers and waterways to estuarine and coastal ecosystems. Concerning marine and estuarine animal species, very little is known about how these species are affected by the exposure to freshwater cyanobacteria and cyanotoxins. So far, most of the knowledge has been gathered from freshwater bivalve molluscs. This work aimed to infer the sensitivity of the marine mussel Mytilus galloprovincialis to single as well as mixed toxic cyanobacterial cultures and the underl

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Jalili, Farhad, Hana Trigui, Juan Francisco Guerra Maldonado, Sarah Dorner, Arash Zamyadi, B. Jesse Shapiro, Yves Terrat, Nathalie Fortin, Sébastien Sauvé, and Michèle Prévost. "Can Cyanobacterial Diversity in the Source Predict the Diversity in Sludge and the Risk of Toxin Release in a Drinking Water Treatment Plant?" Toxins 13, no. 1 (January 1, 2021): 25. http://dx.doi.org/10.3390/toxins13010025.

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Conventional processes (coagulation, flocculation, sedimentation, and filtration) are widely used in drinking water treatment plants and are considered a good treatment strategy to eliminate cyanobacterial cells and cell-bound cyanotoxins. The diversity of cyanobacteria was investigated using taxonomic cell counts and shotgun metagenomics over two seasons in a drinking water treatment plant before, during, and after the bloom. Changes in the community structure over time at the phylum, genus, and species levels were monitored in samples retrieved from raw water (RW), sludge in the holding tank

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Jalili, Farhad, Hana Trigui, Juan Francisco Guerra Maldonado, Sarah Dorner, Arash Zamyadi, B. Jesse Shapiro, Yves Terrat, Nathalie Fortin, Sébastien Sauvé, and Michèle Prévost. "Impact of Stagnation on the Diversity of Cyanobacteria in Drinking Water Treatment Plant Sludge." Toxins 14, no. 11 (October 31, 2022): 749. http://dx.doi.org/10.3390/toxins14110749.

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Health-related concerns about cyanobacteria-laden sludge of drinking water treatment plants (DWTPs) have been raised in the past few years. Microscopic taxonomy, shotgun metagenomic sequencing, and microcystin (MC) measurement were applied to study the fate of cyanobacteria and cyanotoxins after controlled sludge storage (stagnation) in the dark in a full-scale drinking water treatment plant within 7 to 38 days. For four out of eight dates, cyanobacterial cell growth was observed by total taxonomic cell counts during sludge stagnation. The highest observed cell growth was 96% after 16 days of

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Burberg, Christian, Thomas Petzoldt, and Eric von Elert. "Phosphate Limitation Increases Content of Protease Inhibitors in the Cyanobacterium Microcystis aeruginosa." Toxins 12, no. 1 (January 6, 2020): 33. http://dx.doi.org/10.3390/toxins12010033.

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Increased anthropogenic nutrient input has led to eutrophication of lakes and ponds, resulting worldwide in more frequent and severe cyanobacterial blooms. In particular, enhanced availability of phosphorus (P) can promote cyanobacterial mass developments and may affect the content of secondary metabolites in cyanobacteria, such as protease inhibitors (PIs). PIs are common among cyanobacteria and have been shown to negatively affect herbivorous zooplankton. Here, we test the hypothesis that P-limitation reduces the growth of Microcystis, but increases the content of PIs. In batch culture exper

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Chia, Mathias Ahii, Ilu Ameh, Korie Chibuike George, Emmanuel Oluwadare Balogun, Suwebat Ayanronke Akinyemi, and Adriana Sturion Lorenzi. "Genetic Diversity of Microcystin Producers (Cyanobacteria) and Microcystin Congeners in Aquatic Resources across Africa: A Review Paper." Toxics 10, no. 12 (December 10, 2022): 772. http://dx.doi.org/10.3390/toxics10120772.

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Microcystins are produced by multifaceted organisms called cyanobacteria, which are integral to Africa’s freshwater environments. The excessive proliferation of cyanobacteria caused by rising temperature and eutrophication leads to the production and release of copious amounts of microcystins, requiring critical management and control approaches to prevent the adverse environmental and public health problems associated with these bioactive metabolites. Despite hypotheses reported to explain the phylogeography and mechanisms responsible for cyanobacterial blooms in aquatic water bodies, many as

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Vilar, Mauro C. P., Thiago F. C. P. Rodrigues, Luan O. Silva, Ana Beatriz F. Pacheco, Aloysio S. Ferrão-Filho, and Sandra M. F. O. Azevedo. "Ecophysiological Aspects and sxt Genes Expression Underlying Induced Chemical Defense in STX-Producing Raphidiopsis raciborskii (Cyanobacteria) against the Zooplankter Daphnia gessneri." Toxins 13, no. 6 (June 8, 2021): 406. http://dx.doi.org/10.3390/toxins13060406.

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Cyanobacteria stand out among phytoplankton when they form massive blooms and produce toxins. Because cyanotoxin genes date to the origin of metazoans, the hypothesis that cyanotoxins function as a defense against herbivory is still debated. Although their primary cellular function might vary, these metabolites could have evolved as an anti-predator response. Here we evaluated the physiological and molecular responses of a saxitoxin-producing Raphidiopsis raciborskii to infochemicals released by the grazer Daphnia gessneri. Induced chemical defenses were evidenced in R. raciborskii as a signif

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Park, Bum Soo, Chong-Sung Park, Yuna Shin, Sungae Yoon, Myung-Soo Han, and Yoon-Ho Kang. "Different Algicidal Modes of the Two Bacteria Aeromonas bestiarum HYD0802-MK36 and Pseudomonas syringae KACC10292T against Harmful Cyanobacteria Microcystis aeruginosa." Toxins 14, no. 2 (February 8, 2022): 128. http://dx.doi.org/10.3390/toxins14020128.

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Blooms of harmful cyanobacteria Microcystis aeruginosa lead to an adverse effect on freshwater ecosystems, and thus extensive studies on the control of this cyanobacteria’s blooms have been conducted. Throughout this study, we have found that the two bacteria Aeromonas bestiarum HYD0802-MK36 and Pseudomonas syringae KACC10292T are capable of killing M. aeruginosa. Interestingly, these two bacteria showed different algicidal modes. Based on an algicidal range test using 15 algal species (target and non-target species), HYD0802-MK36 specifically attacked only target cyanobacteria M. aeruginosa,

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Hartnell, David M., Ian J. Chapman, Nick G. H. Taylor, Genoveva F. Esteban, Andrew D. Turner, and Daniel J. Franklin. "Cyanobacterial Abundance and Microcystin Profiles in Two Southern British Lakes: The Importance of Abiotic and Biotic Interactions." Toxins 12, no. 8 (August 5, 2020): 503. http://dx.doi.org/10.3390/toxins12080503.

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Freshwater cyanobacteria blooms represent a risk to ecological and human health through induction of anoxia and release of potent toxins; both conditions require water management to mitigate risks. Many cyanobacteria taxa may produce microcystins, a group of toxic cyclic heptapeptides. Understanding the relationships between the abiotic drivers of microcystins and their occurrence would assist in the implementation of targeted, cost-effective solutions to maintain safe drinking and recreational waters. Cyanobacteria and microcystins were measured by flow cytometry and liquid chromatography cou

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Menezes, Carina, Elisabete Valério, Maria João Botelho, and Elsa Dias. "Isolation and Characterization of Cylindrospermopsis raciborskii Strains from Finished Drinking Water." Toxins 12, no. 1 (January 8, 2020): 40. http://dx.doi.org/10.3390/toxins12010040.

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In the summer of 2015, an intense cyanobacterial bloom producing geosmin/2-methylisoborneol (MIB) occurred in the Roxo freshwater reservoir in Alentejo, Portugal. The drinking water supplied from the Roxo water treatment plant (WTP) exhibited an unpleasant odor/taste and a significant cyanobacteria density was detected in the finished water at the exit of the WTP. Cyanobacteria were not evaluated downstream of the WTP, namely, at the city reservoir. The aim of this work was to isolate and characterize viable cyanobacteria present in finished water (exit of the WTP and city reservoir) that with

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Lusty, Mark W., and Christopher J. Gobler. "The Efficacy of Hydrogen Peroxide in Mitigating Cyanobacterial Blooms and Altering Microbial Communities across Four Lakes in NY, USA." Toxins 12, no. 7 (June 29, 2020): 428. http://dx.doi.org/10.3390/toxins12070428.

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Hydrogen peroxide (H2O2) has been proposed as an agent to mitigate toxic cyanobacterial blooms due to the heightened sensitivity of cyanobacteria to reactive oxygen species relative to eukaryotic organisms. Here, experiments were conducted using water from four diverse, eutrophic lake ecosystems to study the effects of H2O2 on cyanobacteria and non-target members of the microbial community. H2O2 was administered at 4 µg L−1 and a combination of fluorometry, microscopy, flow cytometry, and high throughput DNA sequencing were used to quantify the effects on eukaryotic and prokaryotic plankton co

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Moradinejad, Saber, Hana Trigui, Juan Francisco Guerra Maldonado, Jesse Shapiro, Yves Terrat, Arash Zamyadi, Sarah Dorner, and Michèle Prévost. "Diversity Assessment of Toxic Cyanobacterial Blooms during Oxidation." Toxins 12, no. 11 (November 20, 2020): 728. http://dx.doi.org/10.3390/toxins12110728.

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Fresh-water sources of drinking water are experiencing toxic cyanobacterial blooms more frequently. Chemical oxidation is a common approach to treat cyanobacteria and their toxins. This study systematically investigates the bacterial/cyanobacterial community following chemical oxidation (Cl2, KMnO4, O3, H2O2) using high throughput sequencing. Raw water results from high throughput sequencing show that Proteobacteria, Actinobacteria, Cyanobacteria and Bacteroidetes were the most abundant phyla. Dolichospermum, Synechococcus, Microcystis and Nostoc were the most dominant genera. In terms of spec

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Sehnal, Luděk, Marie Smutná, Lucie Bláhová, Pavel Babica, Petra Šplíchalová, and Klára Hilscherová. "The Origin of Teratogenic Retinoids in Cyanobacteria." Toxins 14, no. 9 (September 15, 2022): 636. http://dx.doi.org/10.3390/toxins14090636.

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Although information about the occurrence and distribution of retinoids in the environment is scarce, cyanobacterial water blooms have been identified as a significant source of these small molecules. Despite the confirmed presence of retinoids in the freshwater blooms dominated by cyanobacteria and their described teratogenic effects, reliable identification of retinoid producers and the mechanism of their biosynthesis is missing. In this study, the cultures of several taxonomically diverse species of axenic cyanobacteria were confirmed as significant producers of retinoid-like compounds. The

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Zervou, Sevasti-Kiriaki, Triantafyllos Kaloudis, Spyros Gkelis, Anastasia Hiskia, and Hanna Mazur-Marzec. "Anabaenopeptins from Cyanobacteria in Freshwater Bodies of Greece." Toxins 14, no. 1 (December 21, 2021): 4. http://dx.doi.org/10.3390/toxins14010004.

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Cyanobacteria are photosynthetic microorganisms that are able to produce a large number of secondary metabolites. In freshwaters, under favorable conditions, they can rapidly multiply, forming blooms, and can release their toxic/bioactive metabolites in water. Among them, anabaenopeptins (APs) are a less studied class of cyclic bioactive cyanopeptides. The occurrence and structural variety of APs in cyanobacterial blooms and cultured strains from Greek freshwaters were investigated. Cyanobacterial extracts were analyzed with LC–qTRAP MS/MS using information-dependent acquisition in enhanced io

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Wang, Zi-Qian, Suqin Wang, Ju-Yuan Zhang, Gui-Ming Lin, Nanqin Gan, Lirong Song, Xiaoli Zeng та Cheng-Cai Zhang. "The Proposed Neurotoxin β-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the Cyanobacterium Anabaena PCC 7120". Toxins 12, № 8 (13 серпня 2020): 518. http://dx.doi.org/10.3390/toxins12080518.

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Produced by cyanobacteria and some plants, BMAA is considered as an important environmental factor in the occurrence of some neurodegenerative diseases. Neither the underlying mechanism of its toxicity, nor its biosynthetic or metabolic pathway in cyanobacteria is understood. Interestingly, BMAA is found to be toxic to some cyanobacteria, making it possible to dissect the mechanism of BMAA metabolism by genetic approaches using these organisms. In this study, we used the cyanobacterium Anabaena PCC 7120 to isolate BMAA-resistant mutants. Following genomic sequencing, several mutations were map

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Czyżewska, Wanda, Marlena Piontek, and Katarzyna Łuszczyńska. "The Occurrence of Potential Harmful Cyanobacteria and Cyanotoxins in the Obrzyca River (Poland), a Source of Drinking Water." Toxins 12, no. 5 (April 28, 2020): 284. http://dx.doi.org/10.3390/toxins12050284.

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Harmful cyanobacteria and their cyanotoxins may contaminate drinking water resources and their effective control remains challenging. The present study reports on cyanobacterial blooms and associated cyanotoxins in the Obrzyca River, a source of drinking water in Poland. The river was examined from July to October 2019 and concentrations of microcystins, anatoxin-a, and cylindrospermopsin were monitored. The toxicity of water samples was also tested using an ecotoxicological assay. All studied cyanotoxins were detected with microcystins revealing the highest levels. Maximal microcystin concent

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Le, Kim Thien Nguyen, Eyerusalem Goitom, Hana Trigui, Sébastien Sauvé, Michèle Prévost, and Sarah Dorner. "The Effects of Ferric Sulfate (Fe2(SO4)3) on the Removal of Cyanobacteria and Cyanotoxins: A Mesocosm Experiment." Toxins 13, no. 11 (October 23, 2021): 753. http://dx.doi.org/10.3390/toxins13110753.

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Cyanobacterial blooms are a global concern. Chemical coagulants are used in water treatment to remove contaminants from the water column and could potentially be used in lakes and reservoirs. The aims of this study was to: 1) assess the efficiency of ferric sulfate (Fe2(SO4)3) coagulant in removing harmful cyanobacterial cells from lake water with cyanobacterial blooms on a short time scale, 2) determine whether some species of cyanobacteria can be selectively removed, and 3) determine the differential impact of coagulants on intra- and extra-cellular toxins. Our main results are: (i) more tha

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Panksep, Kristel, Marju Tamm, Evanthia Mantzouki, Anne Rantala-Ylinen, Reet Laugaste, Kaarina Sivonen, Olga Tammeorg, and Veljo Kisand. "Using Microcystin Gene Copies to Determine Potentially-Toxic Blooms, Example from a Shallow Eutrophic Lake Peipsi." Toxins 12, no. 4 (March 26, 2020): 211. http://dx.doi.org/10.3390/toxins12040211.

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Global warming, paired with eutrophication processes, is shifting phytoplankton communities towards the dominance of bloom-forming and potentially toxic cyanobacteria. The ecosystems of shallow lakes are especially vulnerable to these changes. Traditional monitoring via microscopy is not able to quantify the dynamics of toxin-producing cyanobacteria on a proper spatio-temporal scale. Molecular tools are highly sensitive and can be useful as an early warning tool for lake managers. We quantified the potential microcystin (MC) producers in Lake Peipsi using microscopy and quantitative polymerase

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Śliwińska-Wilczewska, Sylwia, Aldo Barreiro Felpeto, Katarzyna Możdżeń, Vitor Vasconcelos, and Adam Latała. "Physiological Effects on Coexisting Microalgae of the Allelochemicals Produced by the Bloom-Forming Cyanobacteria Synechococcus sp. and Nodularia Spumigena." Toxins 11, no. 12 (December 6, 2019): 712. http://dx.doi.org/10.3390/toxins11120712.

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Only a few studies have documented the physiological effects of allelopathy from cyanobacteria against coexisting microalgae. We investigated the allelopathic ability of the bloom-forming cyanobacteria Synechococcus sp. and Nodularia spumigena filtrates on several aspects related to the physiology of the target species: population growth, cell morphology, and several indexes of photosynthesis rate and respiration. The target species were the following: two species of green algae (Oocystis submarina, Chlorella vulgaris) and two species of diatoms (Bacillaria paxillifer, Skeletonema marinoi). Th

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Konstantinou, Despoina, Eleni Mavrogonatou, Sevasti-Kiriaki Zervou, Panagiotis Giannogonas, and Spyros Gkelis. "Bioprospecting Sponge-Associated Marine Cyanobacteria to Produce Bioactive Compounds." Toxins 12, no. 2 (January 23, 2020): 73. http://dx.doi.org/10.3390/toxins12020073.

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Marine cyanobacteria are considered a prolific source of bioactive natural products with a range of biotechnological and pharmacological applications. However, data on the production of natural compounds from sponge-associated cyanobacteria are scarce. This study aimed to assess the potential of sponge-associated cyanobacteria strains representing different taxonomic groups for the production of bioactive compounds and the biological activity of their extracts. Phylogenetic analysis of sponge-associated cyanobacteria and screening for the presence of genes encoding non-ribosomal peptide synthe

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Henao, Eliana, Piotr Rzymski, and Matthew Waters. "A Review on the Study of Cyanotoxins in Paleolimnological Research: Current Knowledge and Future Needs." Toxins 12, no. 1 (December 20, 2019): 6. http://dx.doi.org/10.3390/toxins12010006.

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Cyanobacterial metabolites are increasingly studied, in regards to their biosynthesis, ecological role, toxicity, and potential biomedical applications. However, the history of cyanotoxins prior to the last few decades is virtually unknown. Only a few paleolimnological studies have been undertaken to date, and these have focused exclusively on microcystins and cylindrospermopsins, both successfully identified in lake sediments up to 200 and 4700 years old, respectively. In this paper, we review direct extraction, quantification, and application of cyanotoxins in sediment cores, and put forward

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Douma, Mountasser, Mohammed Loudiki, Brahim Oudra, Khadija Mouhri, Youness Ouahid, and Francisca F. del Campo. "Taxonomic diversity and toxicological assessment of Cyanobacteria in Moroccan inland waters." Revue des sciences de l'eau 22, no. 3 (August 3, 2009): 435–49. http://dx.doi.org/10.7202/037781ar.

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AbstractResearch on the ecology, biodiversity and toxicology of cyanobacteria in Moroccan inland waters has been carried out since 1994. The results demonstrate the existence of several taxa of cyanobacteria. Most of them are toxic, bloom‑forming species present in various water bodies of the country. The present study follows upon this earlier work and spans the 2003-2006 period. The major aim was to update and supplement the existing national cyanobacteria inventory and to isolate new toxic strains. During the study period, more than 40 aquatic environments were visited and sampled.Almost 30

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Koksharova, Olga A., Ivan O. Butenko, Olga V. Pobeguts, Nina A. Safronova, and Vadim M. Govorun. "The First Proteomic Study of Nostoc sp. PCC 7120 Exposed to Cyanotoxin BMAA under Nitrogen Starvation." Toxins 12, no. 5 (May 9, 2020): 310. http://dx.doi.org/10.3390/toxins12050310.

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The oldest prokaryotic photoautotrophic organisms, cyanobacteria, produce many different metabolites. Among them is the water-soluble neurotoxic non-protein amino acid beta-N-methylamino-L-alanine (BMAA), whose biological functions in cyanobacterial metabolism are of fundamental scientific and practical interest. An early BMAA inhibitory effect on nitrogen fixation and heterocyst differentiation was shown in strains of diazotrophic cyanobacteria Nostoc sp. PCC 7120, Nostoc punctiforme PCC 73102 (ATCC 29133), and Nostoc sp. strain 8963 under conditions of nitrogen starvation. Herein, we present

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Guerreiro, Adriana, Mariana A. Andrade, Carina Menezes, Fernanda Vilarinho, and Elsa Dias. "Antioxidant and Cytoprotective Properties of Cyanobacteria: Potential for Biotechnological Applications." Toxins 12, no. 9 (August 26, 2020): 548. http://dx.doi.org/10.3390/toxins12090548.

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Antioxidant compounds from cyanobacteria may constitute a natural alternative to current synthetic antioxidants, which contain preservatives and suspected toxicity. In this work, we evaluate the antioxidant potential of cyanobacterial strains of distinct species/genus isolated from freshwater (n = 6), soil (n = 1) and wastewater (n = 1) environments. Lyophilized biomass obtained from in-vitro cultures of those strains was extracted with ethanol and methanol. The antioxidant potential was evaluated by chemical (DPPH scavenging method, β-carotene bleaching assay, determination of total phenolic

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Le, Kim Thien Nguyen, Juan Francisco Guerra Maldonado, Eyerusalem Goitom, Hana Trigui, Yves Terrat, Thanh-Luan Nguyen, Barry Husk, et al. "Shotgun Metagenomic Sequencing to Assess Cyanobacterial Community Composition following Coagulation of Cyanobacterial Blooms." Toxins 14, no. 10 (October 7, 2022): 688. http://dx.doi.org/10.3390/toxins14100688.

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The excessive proliferation of cyanobacteria in surface waters is a widespread problem worldwide, leading to the contamination of drinking water sources. Short- and long-term solutions for managing cyanobacterial blooms are needed for drinking water supplies. The goal of this research was to investigate the cyanobacteria community composition using shotgun metagenomics in a short term, in situ mesocosm experiment of two lakes following their coagulation with ferric sulfate (Fe2(SO4)3) as an option for source water treatment. Among the nutrient paramenters, dissolved nitrogen was related to Mic

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Racine, Marianne, Ammar Saleem, and Frances R. Pick. "Metabolome Variation between Strains of Microcystis aeruginosa by Untargeted Mass Spectrometry." Toxins 11, no. 12 (December 11, 2019): 723. http://dx.doi.org/10.3390/toxins11120723.

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Cyanobacteria are notorious for their potential to produce hepatotoxic microcystins (MCs), but other bioactive compounds synthesized in the cells could be as toxic, and thus present interest for characterization. Ultra performance liquid chromatography and high-resolution accurate mass spectrometry (UPLC-QTOF-MS/MS) combined with untargeted analysis was used to compare the metabolomes of five different strains of the common bloom-forming cyanobacterium, Microcystis aeruginosa. Even in microcystin-producing strains, other classes of oligopeptides including cyanopeptolins, aeruginosins, and aeru

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Koksharova, Olga A., та Nina A. Safronova. "Non-Proteinogenic Amino Acid β-N-Methylamino-L-Alanine (BMAA): Bioactivity and Ecological Significance". Toxins 14, № 8 (7 серпня 2022): 539. http://dx.doi.org/10.3390/toxins14080539.

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Research interest in a non-protein amino acid β-N-methylamino-L-alanine (BMAA) arose due to the discovery of a connection between exposure to BMAA and the occurrence of neurodegenerative diseases. Previous reviews on this topic either considered BMAA as a risk factor for neurodegenerative diseases or focused on the problems of detecting BMAA in various environmental samples. Our review is devoted to a wide range of fundamental biological problems related to BMAA, including the molecular mechanisms of biological activity of BMAA and the complex relationships between producers of BMAA and the en

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Budzałek, Gracjana, Sylwia Śliwińska-Wilczewska, Marek Klin, Kinga Wiśniewska, Adam Latała, and Józef Maria Wiktor. "Changes in Growth, Photosynthesis Performance, Pigments, and Toxin Contents of Bloom-Forming Cyanobacteria after Exposure to Macroalgal Allelochemicals." Toxins 13, no. 8 (August 23, 2021): 589. http://dx.doi.org/10.3390/toxins13080589.

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Macroalgae can directly restrict the growth of various phytoplankton species by releasing allelopathic compounds; therefore, considerable attention should be paid to the allelopathic potential of these organisms against harmful and bloom-forming cyanobacteria. The main aim of this study was to demonstrate for the first time the allelopathic activity of Ulva intestinalis on the growth, the fluorescence parameters: the maximum PSII quantum efficiency (Fv/Fm) and the effective quantum yield of PSII photochemistry (ΦPSII), the chlorophyll a (Chl a) and carotenoid (Car) content, and the microcystin

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Piel, Tim, Giovanni Sandrini, Emily White, Tianshuo Xu, J. Merijn Schuurmans, Jef Huisman, and Petra M. Visser. "Suppressing Cyanobacteria with Hydrogen Peroxide Is More Effective at High Light Intensities." Toxins 12, no. 1 (December 31, 2019): 18. http://dx.doi.org/10.3390/toxins12010018.

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Hydrogen peroxide (H2O2) can be used as an emergency method to selectively suppress cyanobacterial blooms in lakes and drinking water reservoirs. However, it is largely unknown how environmental parameters alter the effectiveness of H2O2 treatments. In this study, the toxic cyanobacterial strain Microcystis aeruginosa PCC 7806 was treated with a range of H2O2 concentrations (0 to 10 mg/L), while being exposed to different light intensities and light colors. H2O2 treatments caused a stronger decline of the photosynthetic yield in high light than in low light or in the dark, and also a stronger

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Lu, Tao, Qi Zhang, Zhenyan Zhang, Baolan Hu, Jianmeng Chen, Jun Chen, and Haifeng Qian. "Pollutant toxicology with respect to microalgae and cyanobacteria." Journal of Environmental Sciences 99 (January 2021): 175–86. http://dx.doi.org/10.1016/j.jes.2020.06.033.

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Ikehara, Tsuyoshi, Kyoko Kuniyoshi, Haruyo Yamaguchi, Yuuhiko Tanabe, Tomoharu Sano, Masahiro Yoshimoto, Naomasa Oshiro, Shihoko Nakashima, and Mina Yasumoto-Hirose. "First Report of Microcystis Strains Producing MC-FR and -WR Toxins in Japan." Toxins 11, no. 9 (September 9, 2019): 521. http://dx.doi.org/10.3390/toxins11090521.

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Microcystins (MCs) are a group of cyclic heptapeptide hepatotoxins produced by Microcystis and several other genera of cyanobacteria. Many structural variants have been characterized using various methods such as liquid chromatography–mass spectrometry (LC-MS) analysis, enzyme-linked immunosorbent assay (ELISA) and protein phosphatase 2A (PP2A) inhibition assay. The representative MC, MC-LR, and related cyanobacterial toxins strongly inhibit PP2A activity and can therefore be assayed by measuring the extent of PP2A inhibition. However, these methods require reference toxin standards for the qu

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Brózman, Ondřej, Barbara Kubickova, Pavel Babica, and Petra Laboha. "Microcystin-LR Does Not Alter Cell Survival and Intracellular Signaling in Human Bronchial Epithelial Cells." Toxins 12, no. 3 (March 7, 2020): 165. http://dx.doi.org/10.3390/toxins12030165.

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Changes in ecological and environmental factors lead to an increased occurrence of cyanobacterial water blooms, while secondary metabolites-producing cyanobacteria pose a threat to both environmental and human health. Apart from oral and dermal exposure, humans may be exposed via inhalation and/or swallowing of contaminated water and aerosols. Although many studies deal with liver toxicity, less information about the effects in the respiratory system is available. We investigated the effects of a prevalent cyanotoxin, microcystin-LR (MC-LR), using respiratory system-relevant human bronchial ep

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Zhang, Weizhen, Jing Liu, Yunxing Xiao, Yumiao Zhang, Yangjinzhi Yu, Zheng Zheng, Yafeng Liu, and Qi Li. "The Impact of Cyanobacteria Blooms on the Aquatic Environment and Human Health." Toxins 14, no. 10 (September 23, 2022): 658. http://dx.doi.org/10.3390/toxins14100658.

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Cyanobacteria blooms are a global aquatic environment problem. In recent years, due to global warming and water eutrophication, the surface cyanobacteria accumulate in a certain area to form cyanobacteria blooms driven by wind. Cyanobacteria blooms change the physical and chemical properties of water and cause pollution. Moreover, cyanobacteria release organic matter, N (nitrogen) and P (phosphorus) into the water during their apoptosis, accelerating the eutrophication of the water, threatening aquatic flora and fauna, and affecting the community structure and abundance of microorganisms in th

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Palikova, Miroslava, Radovan Kopp, Jiri Kohoutek, Ludek Blaha, Jan Mares, Petra Ondrackova, Ivana Papezikova, Hana Minarova, Lubomir Pojezdal, and Ondrej Adamovsky. "Cyanobacteria Microcystis aeruginosa Contributes to the Severity of Fish Diseases: A Study on Spring Viraemia of Carp." Toxins 13, no. 9 (August 28, 2021): 601. http://dx.doi.org/10.3390/toxins13090601.

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Fish are exposed to numerous stressors in the environment including pollution, bacterial and viral agents, and toxic substances. Our study with common carps leveraged an integrated approach (i.e., histology, biochemical and hematological measurements, and analytical chemistry) to understand how cyanobacteria interfere with the impact of a model viral agent, Carp sprivivirus (SVCV), on fish. In addition to the specific effects of a single stressor (SVCV or cyanobacteria), the combination of both stressors worsens markers related to the immune system and liver health. Solely combined exposure re

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Olokotum, Mark, Jean-François Humbert, Catherine Quiblier, William Okello, Ronald Semyalo, Marc Troussellier, Benjamin Marie, Kathrin Baumann, Rainer Kurmayer, and Cécile Bernard. "Characterization of Potential Threats from Cyanobacterial Toxins in Lake Victoria Embayments and during Water Treatment." Toxins 14, no. 10 (September 23, 2022): 664. http://dx.doi.org/10.3390/toxins14100664.

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Africa’s water needs are often supported by eutrophic water bodies dominated by cyanobacteria posing health threats to riparian populations from cyanotoxins, and Lake Victoria is no exception. In two embayments of the lake (Murchison Bay and Napoleon Gulf), cyanobacterial surveys were conducted to characterize the dynamics of cyanotoxins in lake water and water treatment plants. Forty-six cyanobacterial taxa were recorded, and out of these, fourteen were considered potentially toxigenic (i.e., from the genera Dolichospermum, Microcystis, Oscillatoria, Pseudanabaena and Raphidiopsis). A higher

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Koksharova, Olga A., Ivan O. Butenko, Olga V. Pobeguts, Nina A. Safronova та Vadim M. Govorun. "Proteomic Insights into Starvation of Nitrogen-Replete Cells of Nostoc sp. PCC 7120 under β-N-Methylamino-L-Alanine (BMAA) Treatment". Toxins 12, № 6 (4 червня 2020): 372. http://dx.doi.org/10.3390/toxins12060372.

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All cyanobacteria produce a neurotoxic non-protein amino acid β-N-methylamino-L-alanine (BMAA). However, the biological function of BMAA in the regulation of cyanobacteria metabolism still remains undetermined. It is known that BMAA suppresses the formation of heterocysts in diazotrophic cyanobacteria under nitrogen starvation conditions, and BMAA induces the formation of heterocyst-like cells under nitrogen excess conditions, by causing the expression of heterocyst-specific genes that are usually “silent” under nitrogen-replete conditions, as if these bacteria receive a nitrogen deficiency in

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