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Dissertations / Theses on the topic 'Cyclen'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Michaelis, Katrin. "Design, Synthese und molekularbiologische Evaluierung synthetischer Ribonucleasen mit Cyclen-Grundgerüst." [S.l.] : [s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=960909303.

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2

Kaushik, Vivek. "Synthesis of cyclen based receptors and their use in separations biotechnology." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2611.

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A number of purification techniques such as adsorption, centrifugation, chromatography, extraction, distillation, filtration, precipitation etc. to name a few, are commonly used for the purification. However, due to a constant need of purification of even more complex crude mixtures, be it reaction mixtures, various proteins and DNA from cell extracts or medicinal compounds and fragrances from plant extracts, scientists needed to consistently develop new and improved techniques of purification. One such great advancement in the field of chromatography was the development of affinity chromatogr

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3

Ganß, Alexander [Verfasser], and Stefan [Akademischer Betreuer] Kubik. "Neuartige supramolekulare Koordinationsverbindungen mit Cyclen- oder Cyclopeptiduntereinheiten / Alexander Ganß. Betreuer: Stefan Kubik." Kaiserslautern : Technische Universität Kaiserslautern, 2016. http://d-nb.info/1108270468/34.

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4

Fok, Wanyiu. "Theranostic porphyrin-cyclen gadolinium complex for photodynamic therapy and magnetic resonance imaging." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/706.

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Photodynamic therapy (PDT) and Magnetic resonance imaging (MRI) are two techniques used in therapeutic and diagnostic purpose respectively. PDT can selectively kill the cancer cells by utilizing light and photosensitizer, while MRI provides invasive imaging on our interior bodies. If these two techniques combine, the probe can act as both PDT and MRI agent at the same time. This theranostic agents can bring great efficiency in the cancer treatment. In this project, a porphyrin-cyclen gadolinium based dual functions bio-probe, PZnGdL, is designed for diagnostic and photodynamic therapeutic func

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5

Bernier, Nicolas. "Macrocycles en série tétraazacycloalacnes : synthèse et étude de complexation de dérivés du cyclen." Brest, 2007. http://www.theses.fr/2007BRES2018.

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Le travail consiste en la synthèse de ligands dimériques de type renforcés basés sur l’unité cyclen ainsi qu’en l’étude de leurs caractéristiques acido-basiques et de leurs propriétés complexantes vis-à-vis du cuivre (II) et de l’anion triphosphate. La voie de synthèse nécessite la mono-N et la frans-di-N-fonctionnalisation spécifique du cyclen. La stratégie développée au laboratoire, utilisant l’outil “aminal”, a été appliquée à la synthèse de quatre nouvelles familles de ligands renforcés. La méthodes est aisée et efficace. Les études préalables de protonation ont montré que les ligands dimé

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6

Walter, Jürgen [Verfasser]. "Cyclisierung von Tetraprolin : Aufbau verschiedener diastereomerer Cyclen aus D- und L-Prolin / Jürgen Walter." Ulm : Universität Ulm. Fakultät für Naturwissenschaften, 2000. http://d-nb.info/101547053X/34.

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7

jayasinha, arachchige Rajith Madushanka. "Solid-State NMR Structural Studies of Proteins Using Cyclen Based Paramagnetic Metal Chelating Probes." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461765391.

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8

Perera-Bobusch, Chrischani [Verfasser]. "Synthesis and Biological Evaluation of Artificial Metalloproteases Based on Amphiphilic Cyclen Derivatives / Chrischani Perera-Bobusch." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/109466295X/34.

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9

Hormann, Jan [Verfasser]. "DNA-Spaltung durch Kupfer(II)cyclen-basierte Metallonukleasen : Einfluss von Heteroatomaustausch und Interkalatorsubstitution / Jan Hormann." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1099282969/34.

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10

Bradbury, Adam John, and babradbury@optusnet com au. "METAL ION ACTIVATED ANION SENSORS." Flinders University. School of Chemistry Physics and Earth Sciences, 2007. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20080319.125059.

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A series of new, octadentate, fluorescent, macrocyclic ligands have been prepared with a view to using them to study aromatic anion sequestration. The eight-coordinate Cd(II) complexes of the ligands have been shown capable of acting as receptors for a range of aromatic oxoanions. This has been demonstrated by perturbation of both 1H NMR chemical shift values and the anthracene derived fluorescence emission intensity as the potential guest anion and the host are combined. Non-linear least squares regression analysis of the resulting titration curves leads to the determination of binding consta

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11

Pagan, Augustine J. IV. "Heterosandwich assay of nicotinic acetylcholine receptors." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3815.

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Using the technology afforded by Winschel et al., cyclen-1, a high affinity, strong complexation agent for 8-hydroxypyrene-1,3,6 trisulfonate and derivatives, a new assay has been developed for fluorescently labeling proteins of interest (POIs). Ligation of the endogenous ligand for nicotinic acetylcholine receptors (nAChRs), acetylcholine, using click chemistry afforded the triazole derivative of an alkynyl-acylcholine (compound 1) with 8-azidopyrene-1,3,6 trisulfonate (compound 2). Liposomes encapsulated with Rhodamine B were used to strengthen the initial fluorophore response of compound 2,

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12

El, Ghachtouli Sanae. "Caractérisation, étude thermodynamique et structurale de complexes tétraazamacrocycliques porteurs de groupements pyridine ou pyrazine." Reims, 2007. http://theses.univ-reims.fr/exl-doc/GED00000535.pdf.

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L’objectif poursuivi au cours de ce travail est l’étude de l’influence des paramètres structuraux de complexes mono- et bistétraazamacrocycles de cuivre et de nickel sur leurs propriétés électroniques. Les ligands développés dans ce but sont des cyclens et cyclams monoN-fonctionnalisés par des groupements de type pyridine ou des bismacrocycles basés sur des cavités cyclen ou cyclam séparées par des liens de type pyridine ou pyrazine. L’influence de la présence d’atomes coordinants exomacrocycliques sur les caractéristiques stéréochimiques et électroniques des complexes a ainsi été évaluée. Dan

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13

Woinaroschy, Kristina Michaela. "Cyclen transition metal complexes as biomimetic catalysts, phosphate anion sensors and building-blocks in supramolecular assemblies." kostenfrei, 2007. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/890/.

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14

Hodyl, Jozef Andrew Zbigniew, and jozef hodyl@flinders edu au. "Silica Immobilised Metal Ion Activated Molecular Receptors." Flinders University. School of Chemistry, Physics and Earth Sciences, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20090301.162335.

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Immobilisation of functional entities, such as, enzymes, onto solid supports, as a means of facilitating their removal from the surrounding environment and subsequent regeneration has been in practice for many decades. This work focuses on the immobilisation and analysis of three-walled (pendant armed), cyclen based receptor complexes immobilised onto a silica surface for the purpose of sequestering aromatic anions from aqueous solution: Si-GPS-[Cd(Trac)](ClO4)2, Si-GPS-[Cd(DiPTrac)](ClO4)2, and Si-GPS-[Cd(TriPTrac)](ClO4)2 were the immobilised receptors used. Initially, synthesis of a three-

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15

Soibinet, Mathieu. "Complexes du cuivre (II), nickel (II) et cobalt (III) avec des ligands bis macrocycliques dérivés du cyclam et du cyclen : Synthèse, études thermodynamique et structurale." Reims, 2002. http://www.theses.fr/2002REIMS023.

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Des ligands bis-macrocycliques dérivés du cyclam ou du cyclen ont été obtenus par une nouvelle méthode de synthèse via un intermédiaire bis-cis-aminal. L'étude des propriétés thermodynamiques et structurales des complexes formés entre ces ligands et les cations cuivre(II), nickel(II) et cobalt(III) a été réalisée. En solution aqueuse, l'étude potentiométrique et spectroscopique (RPE, UV visible) des complexes du cuivre(II) a montré l'existence, selon la valeur du rapport R = [ligand]/[métal], de complexes mononucléaires ou dinucléaires de très grande stabilité. A l'état solide, les complexes d

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16

Delépine, Anne-Sophie. "Polyamines pour la reconnaissance d'anions d'intérêt biologique." Brest, 2009. http://www.theses.fr/2009BRES2009.

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Les propriétés physico-chimiques complexantes des polyamines cycliques et linéaires sont maintenant clairement établies. Elles forment en effet des complexes très stables avec les cations métalliques et peuvent interagir avec des substrats anioniques en milieu aqueux lorsque les atomes d’azote deviennent accepteurs d’électrons après protonation. Si la complexation des anions s’est développée plus lentement que celles des cations, elle est devenue un domaine de recherche à part entière dès lors que l’importance des complexes des espèces chargées négativement a été reconnue tant au niveau biolog

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17

Franklin, Constance D. "A Novel Synthesis and Subsequent Decyclization of Iminothiozolidinones: Expansion of Thiourea Chemistry for Biological Applications." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4853.

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Small molecule synthesis has become a valuable tool in the study of biological systems. Biologically active compounds can be designed based on well-characterized endogenous systems or they can be found through the screening of large libraries of small molecules. This work involves the development of a small library of cyclic thiourea-based small molecules by use of an unreported synthetic pathway. Briefly, parent thioureas were cyclized by reaction with bromoacetyl bromide, and one or two isomeric heterocycles were found to form. Further studies indicated that the reaction could be easily mani

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18

Kulinna, Heiko [Verfasser]. "Neutral and Cationic Zirconium Alkyl and Hydride Complexes Supported by a Macrocycle Based on Cyclen : Synthesis, Characterization and Reactivity / Heiko Kulinna." Aachen : Shaker, 2013. http://d-nb.info/1051574447/34.

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19

Nouri, Hela. "Synthèse et caractérisations de propriétés optiques d’un nouveau ligand dérivé du Cyclen-azaxanthone : Applications potentielles dans la détection sélective du Zn2+." Thesis, Reims, 2013. http://www.theses.fr/2013REIMS018.

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Le présent travail concerne principalement l'élaboration d'un nouveau ligand en l'occurrence le cyclen-hydrazone, luminescent et efficace pour une détection relativement sélective de l'ion d'intérêt biologique, Zn2+. La synthèse du groupement azaxanthone à greffer sur le cyclen a été décrite. A partir de ces ligands, la complexation de zinc, a été traitée dans le but de développer une sonde optique sélective pour les ions métalliques de la première série de transition. Une étude photophysique associée à un travail de modélisation théorique en solution a plus particulièrement montré la formatio

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20

Gupta, Deepshikha. "NEW APPROACHES TO CYCLOPENTADIENYL-FUSED THIOPHENE COMPLEXES OF IRON and SYNTHESIS AND CHARACTERIZATION OF CARBONIC ANHYDRASE ACTIVE-SITE MIMICS FOR CO₂ HYDRATION." UKnowledge, 2018. https://uknowledge.uky.edu/chemistry_etds/92.

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Polyheterocycles such as polythiophene and its derivatives comprise an important class of conducting polymers used for electronic applications. They have been of great interest for use in electronic materials due to their increased environmental stability as well as novel electronic properties in their polymer states. We have been interested in exploring the electronic properties of organometallic analogues of the low-band-gap polymer poly(benzo[3,4-c]thiophene) (polyisothianaphthene) that incorporates η5-cyclopenta[c]thienyl monomers such as ferroceno[c]thiophene. First chapter of this disser

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21

Lynch, Jonathan D. "Breaking the Organic Mold: Introducing Copper into the Influenza A Arena with Neutral and Divalent Complexes." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8677.

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Influenza A (IVA) continues to pose a growing global threat even as current medications are becoming less effective. One of the main avenues of research into new anti-IVA drugs is its homotetrameric Matrix 2 proton channel (M2A), without which the virus would be unable to release its viral RNA into the host cell. The drug amantadine used to bind and block M2A until near-ubiquitous resistance formed as an M2A-S31N mutation, starting around 1995 and proceeding to 2005 when amantadine was disallowed for use as an anti-IVA drug. The standard organic structure currently being used for M2A inhibitor

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22

Bonnet, Christine. "Un motif sur la cycline B nécessaire à l'activation de CDK1 chez la levure ?" Paris 6, 2002. http://www.theses.fr/2002PA066509.

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23

Asrar, Ahmad Malik. "Testing the cell cycle phase specificity of cyclins: can an earlier cyclin trigger a later event?" Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/127221.

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Progression through the cell cycle is directed by cyclin dependent kinases (CDKs), which are essential for normal and cancer cell proliferation. CDKs are activated by association with cyclins specific to each cell cycle phase (G1, S, G2, and M). Thus, CDK associated with G1 phase cyclins promote the expression of proteins necessary for DNA replication, but is unable to activate it. CDK associated with S phase cyclins, in turn, triggers the activation of chromosomal origins of replication, but is unable to promote chromosome condensation and segregation of sister chromatids, which is carried ou

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24

Waclaw, Ronald Raymond. "Expression of cell cycle regulatory proteins cyclin B1, cyclin E, and cdk2 during the first three cell cycles of preimplantation mouse embryo development using indirect immunofluorescence." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1125042.

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The cell cycle is a highly regulated process driven by endogenous factors that have regulatory functions. Certain proteins such as cyclins and cyclin-dependent kinases (cdks) are needed to progress through the four phases of the cell cycle. Cell cycle regulatory proteins have been characterized in somatic cells and exhibit phase specific expression patterns. However, the changes in expression of these proteins have not been characterized in early cleavage stage mouse embryos. This study utilized indirect immunofluorescence microscopy to determine the expression pattern of cell cycle regulators

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25

Bhaduri, Samyabrata. "Regulation of CDK1 Activity during the G1/S Transition in S. cerevisiae through Specific Cyclin-Substrate Docking: A Dissertation." eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/871.

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Several cell cycle events require specific forms of the cyclin-CDK complexes. It has been known for some time that cyclins not only contribute by activating the CDK but also by choosing substrates and/or specifying the location of the CDK holoenzyme. There are several examples of B-type cyclins identifying certain peptide motifs in their specific substrates through a conserved region in their structure. Such interactions were not known for the G1 class of cyclins, which are instrumental in helping the cell decide whether or not to commit to a new cell cycle, a function that is non-redundant wi

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26

Houriet-Segard, Geneviève. "Logement, cycles démographiques et cycle de vie." Paris, Institut d'études politiques, 1998. http://www.theses.fr/1998IEPP0029.

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Cette thèse comprend trois approches du marché du logement dont l'objectif est de saisir les interactions entre démographie et logement. 1. Analyse de l'influence des cycles démographiques sur la demande agrégée de logement : une revue de modèles macroéconomiques de marché du logement incluant un déterminant démographique est présentée, puis une modélisation du marché du logement est effectuée sur la base de données économiques françaises. L'hypothèse majeure de ce modèle est l'idée d'un surplus systématique d'offre de logement par rapport à la demande dont l'ampleur détermine le prix. Enfin,

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27

Martinsson, Hanna-Stina. "Single cell analysis of checkpoints in G₁ /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-455-4/.

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28

Ji, Jun-Yuan. "Functions of Cdk1-cyclin B in regulating the early embryonic mitoses in Drosophila /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/5124.

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29

Bockstaele, Laurence. "Réévaluation de la régulation de l'activité de la CDK4, kinase dépendante des cyclines D, clé de l'engagement dans le cycle cellulaire: rôle de l'inhibiteur p27." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210626.

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La progression à travers le cycle cellulaire est assurée par l’activation séquentielle d’une série de complexes cycline-CDK. Les complexes cycline D-CDK4 assurent la progression au cours de la phase G1 du cycle cellulaire en phosphorylant les protéines « antioncogéniques » de la famille Rb. L’activation de la CDK4 nécessite son association à une cycline D et sa phosphorylation sur Thr172 par la CAK nucléaire (CDK activating kinase). Le rôle essentiel des protéines de la famille Cip/Kip dans la régulation de l’activité de ces complexes reste controversé. Les protéines de cette famille (comprena

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30

Erlandsson, Fredrik. "Immunofluorescence studies on the cell cycle expression of cyclin A and cyclin E /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-809-2/.

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31

Swanton, Robert Charles. "Viral cyclin disruption of mammalian cell cycle control mechanisms." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286205.

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32

Doare-Michel, Nola. "Relations entre cycle de développement familial et cycles d'identité." Université Claude Bernard - Lyon I, 1994. http://www.theses.fr/1994LYO1M292.

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33

Datar, Sanjeev Ashok. "Developmental regulation of growth and cell cycle progression in Drosophila melanogaster : a larval growth arrest screen, and molecular and genetic analysis of the cyclin D/Cdk4 complex /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/5008.

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34

Zhang, Hong. "Involvement of Cdk/cyclin motif in ciliate cell cycle regulation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0015/NQ56653.pdf.

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35

Ford, Jack Ragnar. "Cyclin dependent kinases and cell cycle control in Trypanosoma brucei." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312512.

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36

Brunner, Benjamin. "The sulfur cycle: from bacterial microenvironment to global biogeochemical cycles /." Zürich : [s.n.], 2003. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=15197.

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37

Powell, Brian Edward. "The influence of minor cycles on low cycle fatigue crack growth." Thesis, University of Portsmouth, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354380.

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Fatigue crack propagation rates have been measured for two titaniumbased aeroengine disc alloys using compact tension test pieces. The loading block employed simulates two features of the engine flight pattern. A major stress cycle represents the start-stop operation which leads to low cycle fatigue. In-flight vibrations, which may give rise to high cycle fatigue, are represented by superimposed minor cycles of high frequency. This combined loading is applied in a specially developed test facility consisting of an electromagnetic vibrator mounted above a servohydrau1ic actuator. When the minor

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38

Campo, Woytuk Nadia. "Curious Cycles: Feminist Probes for Cultivating Curiosity of the Menstrual Cycle." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-254985.

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Curious Cycles responds to the tensions that arise when designing technologies for menstruation and menstrual cycles, touching upon notions of curiosity, noticing, sharing, taking or making space, and our relationships with our bodies and their fluids. The project follows a Research through Design approach, guided by Soma Design and feminist research methods. Curious Cycles are a set of cultural probes; objects and interactions designed to gather experiences and insights from ve people who menstruate, throughout the duration of a cycle (approximately one month). The objects are meant to "culti

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39

Horton, Lynn Elizabeth. "Studies on cyclin structure and pRb phosphorylation in cell cycle control." Case Western Reserve University School of Graduate Studies / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=case1057684343.

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Prasad, Aarathi. "Cell cycle regulation through the D-Type cyclins." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405947.

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Ekholm-Reed, Susanna. "The role of cyclin E in cell cycle regulation and genomic instability /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-894-7/.

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42

Puyol, Marta. "Cell cycle and cancer : the role of cyclin dependent kinases in tumourigenesis." Thesis, Kingston University, 2009. http://eprints.kingston.ac.uk/20409/.

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Most human cancers carry mutations in cell cycle regulators that result in deregulated Cdk activity, which can either be amplification of the cyclins, elimination of the Cdk inhibitors or mutations in the Cdks. These modifications have a high prognostic value. Cdk2 activity has been shown to be upregulated in different kind of tumours (mammary and prostate carcinomas, and lymphomas) due to the mutation of its regulators, p27KiP1 and cyc/in E; and this alteration has a high prognostic value. Moreover, an insensible INK4 point mutation in Cdk4 has been described in human melanomas. To evaluate t

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43

Chow, Jeremy Pak Hong. "Inhibitory phosphorylation of cyclin-dependent kinases in normal cell cycle and checkpoints /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BICH%202003%20CHOW.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 127-148). Also available in electronic version. Access restricted to campus users.

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44

Kernen, Joakim. "Trends, cycles and institutions : -Job polarization and the business cycle in Europe." Thesis, Uppsala universitet, Nationalekonomiska institutionen, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-367063.

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This thesis studies the cyclical aspect of job polarization in Europe. Contributions include offering a comparison to the findings of previous research on the United States, and extending the analysis by introducing labor market institutions. The analysis is done in two parts, first showing that the observed link between job polarization and jobless recoveries in the US is observed in Europe, but not across all countries and business cycles. In Scandinavia, the process of job polarization appears smoother than the spurts observed in the US. The second part involves regression analyses of the r

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45

Plesca, Dragos Costin. "Cyclin E provides a link between Cell Cycle, DNA Repair and Apoptosis." Kent State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=kent1208492093.

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46

Lindqvist, Arne. "Regulation of CDK dephosphorylation in mitotic entry /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-362-0/.

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47

Williams, Lisa Marie. "Cell cycle inhibitors in control of chronic gammaherpesvirus infection /." Connect to abstract via ProQuest. Full text not available online, 2007.

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Thesis (Ph.D. in Microbiology) -- University of Colorado Denver, 2007.<br>Typescript. Abstract available online via ProQuest Digital Dissertations. Includes bibliographical references (leaves 207-223).

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48

Lundgren, Andreas. "The ABC of the cell cycle: roles of the mammalian Cdc25 isoforms /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-639-5/.

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49

Yang, Chen. "Thermodynamic Cycles using Carbon Dioxide as Working Fluid : CO2 transcritical power cycle study." Doctoral thesis, KTH, Tillämpad termodynamik och kylteknik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-50261.

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The interest in utilizing the energy in low‐grade heat sources and waste heat is increasing. There is an abundance of such heat sources, but their utilization today is insufficient, mainly due to the limitations of the conventional power cycles in such applications, such as low efficiency, bulky size or moisture at the expansion outlet (e.g. problems for turbine blades). Carbon dioxide (CO2) has been widely investigated for use as a working fluid in refrigeration cycles, because it has no ozonedepleting potential (ODP) and low global warming potential (GWP). It is also inexpensive, non‐explosi

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50

Zhu, Xi-Ning. "Regulation of cyclin dependent kinase inhibitors during the vertebrate cell cycle : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1324370261&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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