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Journal articles on the topic 'Cyclic endometrium'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Liu, Xiaorui, Lei Zhang, Jiuzeng Cui, et al. "The mRNA and lncRNA landscape of the non-pregnant endometrium during the oestrus cycle in dairy goat." Animal Production Science 59, no. 10 (2019): 1803. http://dx.doi.org/10.1071/an18426.

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Cyclic changes in the endometrium are essential for embryo implantation in mammals; many studies report that such changes constitute a complex process involving numerous molecular mediators. In the present study, goat endometria at oestrus Day 5 and oestrus Day 15 were selected to systematically analyse the transcriptome using strand-specific Ribo-Zero RNA sequencing. Over 120 million high-quality paired-end reads were generated and 440400 transcripts were identified in the endometrial tissue of dairy goats. In total, 489 differentially expressed mRNAs and 854 differentially expressed long non

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2

Song, Gwonhwa, Thomas E. Spencer, and Fuller W. Bazer. "Cathepsins in the Ovine Uterus: Regulation by Pregnancy, Progesterone, and Interferon Tau." Endocrinology 146, no. 11 (2005): 4825–33. http://dx.doi.org/10.1210/en.2005-0768.

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Cathepsins (CTS) are peptidases that have biological roles in degrading extracellular matrix, catabolism of intracellular proteins, and processing of prohormones. Expression of CTSB, CTSD, CTSH, CTSK, CTSL, CTSS, and CTSZ genes was detected in the endometria of cyclic and early pregnant ewes with distinct temporal and spatial expression patterns. In the d 18 and 20 conceptus, expression of CTSB, CTSD, CTSL, and CTSZ mRNA was detected in the trophectoderm. Of particular note, CTSL mRNA was the most abundant CTS mRNA in the ovine endometrium and detected only in the luminal epithelium and superf

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3

Geisert, RD, RM Brenner, RJ Moffatt, JP Harney, T. Yellin, and FW Bazer. "Changes in oestrogen receptor protein, mRNA expression and localization in the endometrium of cyclic and pregnant gilts." Reproduction, Fertility and Development 5, no. 3 (1993): 247. http://dx.doi.org/10.1071/rd9930247.

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Conceptus secretion of oestrogen on Day 11 of gestation is involved with establishment of pregnancy in the pig. Changes in oestrogen receptor (ER) protein, mRNA and cellular localization in the endometrium were evaluated during the oestrous cycle and early pregnancy of the gilt. In nonpregnant gilts, concentration of nuclear ER in the endometrium increased from Days 0 to 12 followed by a decline on Day 15 of the oestrous cycle. In pregnant gilts, changes in endometrial nuclear ER during Days 10, 12, 15 and 18 were similar to that in cyclic pigs. Analysis of endometrial ER mRNA expression did n

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4

Lucas, Emma S., Nigel P. Dyer, Katherine Fishwick, Sascha Ott, and Jan J. Brosens. "Success after failure: the role of endometrial stem cells in recurrent miscarriage." Reproduction 152, no. 5 (2016): R159—R166. http://dx.doi.org/10.1530/rep-16-0306.

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Endometrial stem-like cells, including mesenchymal stem cells (MSCs) and epithelial progenitor cells, are essential for cyclic regeneration of the endometrium following menstrual shedding. Emerging evidence indicates that endometrial MSCs (eMSCs) constitute a dynamic population of cells that enables the endometrium to adapt in response to a failed pregnancy. Recurrent miscarriage is associated with relative depletion of endometrial eMSCs, which not only curtails the intrinsic ability of the endometrium to adapt to reproductive failure but also compromises endometrial decidualization, an obliga

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5

Ponomarenko, Kristina Yu. "Endometrial receptivity in women with disoders in reproductive system." Journal of obstetrics and women's diseases 66, no. 4 (2017): 90–97. http://dx.doi.org/10.17816/jowd66490-97.

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Infertility and miscarriage are unresolved problems of obstetric and gynecological practice. Endometrial dysfunction is considered to be one of the most important factors in pathogenesis of reproductive losses. The usefulness of hormone-dependent cyclic transformation of the endometrium depends on the adequacy of the molecular interaction of sex hormones with specific receptors in the endometrium. The last also play an important role in the implementation of the correct “dialogue” between the blastocyst and endometrium. This review presents recent data on the role of the receptor apparatus of

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6

Partanen, Seppo. "Protein tyrosine phosphatase activity in human endometrium." Reproduction, Fertility and Development 13, no. 3 (2001): 175. http://dx.doi.org/10.1071/rd00106.

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Protein tyrosine phosphatase (PTP) activity was demonstrated in human endometrium by a histochemical method using phosphotyrosine as substrate. For comparative purposes, non-specific acid phosphatase (AcP) activity was also examined. Protein tyrosine phosphatase activity was very low in proliferative and atrophic endometrium, but its activity was increased 9-fold in glandular epithelium during the secretory phase, and 48-fold in predecidual endometrium, induced by a progestagen-releasing intrauterine device, compared with the proliferative endometrium. Thus, PTP activity appeared to be progest

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7

Forde, N., G. B. Duffy, P. A. McGettigan, et al. "Evidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau." Physiological Genomics 44, no. 16 (2012): 799–810. http://dx.doi.org/10.1152/physiolgenomics.00067.2012.

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The aims of this study were to 1) identify the earliest transcriptional response of the bovine endometrium to the presence of the conceptus (using RNAseq), 2) investigate if these genes are regulated by interferon tau (IFNT) in vivo, and 3) determine if they are predictive of the pregnancy status of postpartum dairy cows. RNAseq identified 459 differentially expressed genes (DEGs) between pregnant and cyclic endometria on day 16. Quantitative real-time PCR analysis of selected genes revealed PARP12, ZNFX1, HERC6, IFI16, RNF213, and DDX58 expression increased in pregnant compared with cyclic en

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8

Chen, Qianqian, Aijie Xin, Ronggui Qu, et al. "Expression of ENPP3 in human cyclic endometrium: a novel molecule involved in embryo implantation." Reproduction, Fertility and Development 30, no. 10 (2018): 1277. http://dx.doi.org/10.1071/rd17257.

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Ectonucleotide pyrophosphatase–phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. The objective was to determine ENPP3 expression in human endometrium and its roles in endometrial receptivity and embryo implantation. ENPP3 expression was analysed using immunohistochemistry and western blot assay. The effects of ENPP3 on embryo implantat

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9

Tral, Tatiana G., Darya D. Kruglova, and Gulrukhsor Kh Tolibova. "Morphogenesis of decidual transformation of the endometrium. A literature review." Journal of obstetrics and women's diseases 72, no. 5 (2023): 105–14. http://dx.doi.org/10.17816/jowd531483.

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Decidual transformation of the endometrium is the final stage of the cyclic endometrial transformation during pregnancy. The morphogenesis of endometrial transformation is represented by clearly coordinated hormone-receptor interactions via immunological, angiogenic, and apoptotic factors that are necessary for pregnancy development. The pathology of morphogenesis can cause implantation disorders and early reproductive losses, highlighting the medical and social relevance of this issue. The aim of this review was to analyze the literature data on the morphogenesis of endometrial transfor

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10

Spencer, Thomas E., Niamh Forde, Piotr Dorniak, Thomas R. Hansen, Jared J. Romero, and Patrick Lonergan. "Conceptus-derived prostaglandins regulate gene expression in the endometrium prior to pregnancy recognition in ruminants." REPRODUCTION 146, no. 4 (2013): 377–87. http://dx.doi.org/10.1530/rep-13-0165.

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In cattle, the blastocyst hatches from the zona pellucida on days 8–9 and then forms a conceptus that grows and elongates into an ovoid and then filamentous shape between days 9 and 16. The growing conceptus synthesizes and secretes prostaglandins (PGs) and interferon τ (IFNT). Our hypothesis was that the ovoid conceptus exerts a local effect on the endometrium prior to maternal recognition of pregnancy on day 16 in cattle. In study one, synchronized cyclic heifers received no blastocysts or 20in vitro-produced blastocysts on day 7 and their uteri were collected on day 13. IFNT was not detecte

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11

Kotwica, G., A. Oponowicz, B. Kurowicka, A. Franczak, and I. Bogacka. "The effect of progesterone on oxytocin-stimulated intracellular Ca2+ mobilisation and prostaglandin secretion in porcine endometrium." Polish Journal of Veterinary Sciences 13, no. 4 (2010): 615–22. http://dx.doi.org/10.2478/v10181-010-0012-5.

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The effect of progesterone on oxytocin-stimulated intracellular Ca2+ mobilisation and prostaglandin secretion in porcine endometrium We have studied in the porcine endometrium the expression of oxytocin receptor (OTR) mRNA and the effect of progesterone (P4) on oxytocin/oxytocin receptor (OT/OTR) function concerning intracellular Ca2+mobilisation ([Ca2+]i), prostaglandin F2α (PGF2α) and E2 (PGE2; PG) secretion. Tissue was taken from cyclic and early pregnant pigs (days 14-16). A higher expression of OTR mRNA (P<0.05) was observed in the endometrium of cyclic than pregnant pigs. The stimulat

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12

Tolibova, Gulrukhsor Kh, Tatyana G. Tral, Eduard K. Ailamazyan, and Igor Yu Kogan. "Molecular mechanisms of cyclic transformation of the endometrium." Journal of obstetrics and women's diseases 68, no. 1 (2019): 5–12. http://dx.doi.org/10.17816/jowd6815-12.

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Structural transformation of the endometrium during the menstrual cycle is a genetically determined process and is provided by complex molecular-biological interactions aimed at the onset and development of pregnancy. Sex steroid hormones play a key role in endometrial morphogenesis, which mediate or directly affect angiogenesis and immunogenesis.

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13

Khaskhachikh, Dmytro, and Valentin Potapov. "Influence of microbial colonization of the endometry on its function and development of hyperproliferative conditions." 46, no. 46 (June 27, 2023): 72–79. http://dx.doi.org/10.26565/2313-6693-2023-46-08.

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Abstract. The article provides an overview of literary sources that describe research on the microbiome of the endometrium in women of reproductive age. Thus, in many works, data is given indicating that the uterine cavity is not sterile. Various microorganisms can be found on the surface of the endometrium. So far, there is not enough research on microorganisms that can be considered a normal microbiome of the endometrium and its influence on the function and development of hyperproliferative processes of the endometrium in women. Many studies have proven the undoubted role of the uterine mic

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14

Crha, Karel, Pavel Ventruba, Jana Žáková, et al. "The role of uterine microbiome and epithelial-mesenchymal transition in endometrial function." Medical Journal of Cell Biology 7, no. 3 (2019): 146–51. http://dx.doi.org/10.2478/acb-2019-0020.

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AbstractReproductive period in woman is characterized by cyclic changes of endometrium and its regeneration. The factors important for proper function of the endometrium are anatomical structure, hormonal control and signalling pathways on molecular-genetic level. New knowledge on uterine microbiome, mutual epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) of endometrial cells refine our conception of changes on cellular level, endometrial receptivity and possible causes of endometrial dysfunction. Substantial information on bacterial colonisation of endometri

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15

Song, Gwonhwa, Thomas E. Spencer та Fuller W. Bazer. "Progesterone and Interferon-τ Regulate Cystatin C in the Endometrium". Endocrinology 147, № 7 (2006): 3478–83. http://dx.doi.org/10.1210/en.2006-0122.

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Cystatin C (CST3) is a secreted inhibitor of lysosomal cysteine proteases cathepsins B (CTSB) and CTSL, which are abundant in the ovine endometrium and conceptus. In mice, cathepsins and cystatins play important roles in implantation and placentation. This study determined effects of the estrous cycle, pregnancy, progesterone (P4), and interferon-τ (IFNT) on CST3 in the ovine uterus. In cyclic ewes, CST3 mRNA was low on d 10, increased about 12-fold by d 12, and declined thereafter. In early pregnant ewes, CST3 mRNA was low on d 10 and increased about 130-fold from d 10 to d 20. CST3 mRNA and

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16

Ahn, Hyo Won, Jennifer L. Farmer, Fuller W. Bazer, and Thomas E. Spencer. "Progesterone and interferon tau-regulated genes in the ovine uterine endometrium: identification of periostin as a potential mediator of conceptus elongation." REPRODUCTION 138, no. 5 (2009): 813–25. http://dx.doi.org/10.1530/rep-09-0208.

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During early pregnancy in ruminants, progesterone (P4) and interferon tau (IFNT) act on the endometrium to regulate genes hypothesized to be important for conceptus development and implantation. The present study was conducted to verify several candidate genes (actin α-2, smooth muscle, aorta (ACTA2), collagen, type III, α-1 (COL3A1), periostin (POSTN), secreted protein acidic cysteine-rich (SPARC), S100 calcium-binding protein A2 (S100A2),STAT5Aand transgelin (TAGLN)) regulated by pregnancy, P4, and/or IFNT in the endometrium determined using a custom ovine cDNA array.S100A2mRNA was detected

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17

Burova, Natalia A., Nikolai A. Zharkin, Olga Yu Murzina, and Yulia A. Shatilova. "Current status of endometrial dysfunction in the combined pathology of uterus: a literature review." V.F.Snegirev Archives of Obstetrics and Gynecology 8, no. 4 (2021): 191–98. http://dx.doi.org/10.17816/2313-8726-2021-8-4-191-198.

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Currently, the concern of endometrial dysfunction is still relevant and is of increasing interest. This is because of new factors have been identified that affect the reproductive function in women. Chronic endometritis and endometriosis mainly affect women of childbearing age, which threatens normal cyclic transformation of the endometrium and tissue receptivity. This consequently affects the main function of the endometrium, which is to ensure successful implantation of the fertilized egg and the development of the chorion and embryo. A detailed understanding of the functioning of the endome

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18

Velarde, Michael C., Lusine Aghajanova, Camran R. Nezhat, and Linda C. Giudice. "Increased Mitogen-Activated Protein Kinase Kinase/Extracellularly Regulated Kinase Activity in Human Endometrial Stromal Fibroblasts of Women with Endometriosis Reduces 3′,5′-Cyclic Adenosine 5′-Monophosphate Inhibition of Cyclin D1." Endocrinology 150, no. 10 (2009): 4701–12. http://dx.doi.org/10.1210/en.2009-0389.

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Abstract Endometriosis is characterized by endometrial tissue growth outside the uterus, due primarily to survival, proliferation, and neoangiogenesis of eutopic endometrial cells and fragments refluxed into the peritoneal cavity during menses. Although various signaling molecules, including cAMP, regulate endometrial proliferation, survival, and embryonic receptivity in endometrium of women without endometriosis, the exact molecular signaling pathways in endometrium of women with disease remain unclear. Given the persistence of a proliferative profile and differential expression of genes asso

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19

Gambhire-Bhadugale, Harsha, Umesh Tekawade, and Suhas Herlekar. "An observational study of endometrial pattern in implantation." International Journal of Ayurvedic Medicine 13, no. 4 (2023): 921–24. http://dx.doi.org/10.47552/ijam.v13i4.3112.

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Background: Garbhasambhav Samugri is a concept in Ayurveda which describes factors to bring healthy offspring into the society. The kshetra is one of the four essential factors for the formation and development of the embryo, and the term kshetra is used grossly for women but is specifically used for garbhashaya (uterus). According to modern science, embryo implants in the endometrial lining of uterus. All components of the endometrium undergo cyclic changes which is called as endometrial cycle. The endometrial cycle prepares the endometrium for implantation of the fertilized ovum coming towar

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Mestre Citrinovitz, Ana Cecilia, Thomas Strowitzki, and Ariane Germeyer. "Decreased Autophagy Impairs Decidualization of Human Endometrial Stromal Cells: A Role for ATG Proteins in Endometrial Physiology." International Journal of Molecular Sciences 20, no. 12 (2019): 3066. http://dx.doi.org/10.3390/ijms20123066.

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During the menstrual cycle, the endometrium undergoes cyclic changes of cellular proliferation, differentiation, and death, an essential preparation of the endometrium for its interaction with the implanting embryo. In particular, the differentiation of endometrial stromal cells, named decidualization, ensures the formation of a proper feto-maternal interface for a regulated trophoblast invasion and correct placental orientation and growth. Interestingly, autophagy, an intracellular degradation process of great importance for the maintenance of cellular homeostasis, plays an important role in

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Welter, H., H. Bollwein, F. Weber, S. Rohr, and R. Einspanier. "Expression of endothelial and inducible nitric oxide synthases is modulated in the endometrium of cyclic and early pregnant mares." Reproduction, Fertility and Development 16, no. 7 (2004): 689. http://dx.doi.org/10.1071/rd03103.

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The expression of the endothelial and inducible nitric oxide synthases (eNOS and iNOS, respectively) was examined in the endometrium of cyclic and pregnant mares by real-time polymerase chain reaction and immunohistology. The concentration of eNOS mRNA varied throughout the oestrous cycle, with significantly higher transcripts on Day 5 of the oestrous cycle (P < 0.05), whereas iNOS transcription did not change significantly over time (P > 0.05). In early pregnant mares both eNOS and iNOS mRNA increased between Days 12 and 15 (P < 0.05). In cyclic mares, eNOS protein was detected immun

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Spencer, TE, GH Graf, and FW Bazer. "Sulfated glycoprotein-1 (SGP-1) expression in ovine endometrium during the oestrous cycle and early pregnancy." Reproduction, Fertility and Development 7, no. 5 (1995): 1053. http://dx.doi.org/10.1071/rd9951053.

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This study determined effects of day of oestrous cycle and early pregnancy on sulfated glycoprotein-1 (SGP-1) expression in ovine endometrium. A 364-bp clone of the ovine SGP-1 mRNA was amplified from reverse transcribed Day-15 cyclic endometrial mRNA using the polymerase chain reaction (PCR) and primers specific for the rat SGP-1 mRNA sequence. Nucleotide sequence of the ovine SGP-1 cDNA shared significant identity with rat SGP-1 and human prosaposin. Ewes (n = 40) were hysterectomized on either Day 1, 6, 11, 13 or 15 of the oestrous cycle or on Day 11, 13, 15, 17 or 25 of early pregnancy. To

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Wojciechowicz, B., G. Kotwica, K. Zglejc, E. Waszkiewicz та A. Franczak. "Expression of 17β-hydroxysteroid dehydrogenase and the effects of LH, FSH and prolactin on oestrone and 17β-oestradiol secretion in the endometrium of pigs during early pregnancy and the oestrous cycle". Reproduction, Fertility and Development 29, № 5 (2017): 975. http://dx.doi.org/10.1071/rd15430.

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The endometrium of pregnant and cyclic pigs is a source of oestrone (E1) and 17β-oestradiol (E2). However, the roles of LH, FSH and prolactin (PRL) as regulators of endometrial steroidogenesis, and the presence of 17β-hydroxysteroid dehydrogenase (17β-HSD) in the porcine endometrium, remain unknown. Therefore, in the present study we examined 17β-HSD expression and the effects of LH, FSH and PRL on E1 and E2 release in vitro in endometrial explants harvested from gravid pigs on Days 10–11 (embryo migration within the uterus), 12–13 (maternal recognition of pregnancy) and 15–16 (beginning of im

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24

Chiumia, Daniel, Anna-Katharina Hankele, Anna E. Groebner, et al. "Vascular Endothelial Growth Factor A and VEGFR-1 Change during Preimplantation in Heifers." International Journal of Molecular Sciences 21, no. 2 (2020): 544. http://dx.doi.org/10.3390/ijms21020544.

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Vascular endothelial growth factor A (VEGFA) plays a critical angiogenic role in the endometrium of placentalia during preimplantation. The role of VEGFA and its receptors is not fully characterised in bovine reproduction. We analysed the mRNA expression of VEGFA isoforms 121, 165 and 189, and VEGF receptors 1 and 2 in three experimental settings (A, B and C). We compared intercaruncular endometrium of cyclic to pregnant heifers at Days 12, 15 and 18 post insemination (Day 0), and between Day 15 and Day 18 conceptuses (A). We further compared caruncular versus intercaruncular endometrium at Da

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Tikhomirov, A. L. "Combined oral contraceptives in the prevention of recurrence of typical endometrial hyperplasia of endometrium." Gynecology 20, no. 4 (2018): 26–28. http://dx.doi.org/10.26442/2079-5696_2018.4.26-28.

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Changes in consideration of etiology and pathogenesis of hyperplastic endometrial processes allowed to claim that their preventive maintenance using modern hormonal contraceptives may significantly reduce the frequency and volume surgical treatment. The main protections are ovulation suppression COC mechanism and suppression folliculogenesis, i.e. monthly do not always adequately cyclic processes in endometrium.

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Parrilla, Inmaculada, Cristina A. Martinez, Josep M. Cambra, et al. "Blastocyst-Bearing Sows Display a Dominant Anti-Inflammatory Cytokine Profile Compared to Cyclic Sows at Day 6 of the Cycle." Animals 10, no. 11 (2020): 2028. http://dx.doi.org/10.3390/ani10112028.

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In the context of porcine embryo transfer (ET) technology, understanding the tightly regulated local uterine immune environment is crucial to achieve an adequate interaction between the transferred embryos and the receiving endometrium. However, information is limited on the uterine immune status of cyclic-recipient sows when receiving embryos during ET. The present study postulated that the anti- and proinflammatory cytokine profile 6 days after the onset of estrus differs between endometria from uninseminated cyclic sows and blastocyst-bearing sows. On Day 6 of the cycle, endometrial explant

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Bhartiya, D., and VK Bajpai. "Cyclic alterations in rhesus monkey endometrium by scanning electron microscopy." Reproduction, Fertility and Development 7, no. 5 (1995): 1199. http://dx.doi.org/10.1071/rd9951199.

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The present study was undertaken to correlate the surface topography of endometrium with altered concentrations of circulating steroids during different phases of the artificially-induced menstrual cycle. Scanning electron microscopy demonstrated that oestradiol during the oestrogenic phase induces an increase in the number of ciliated cells and the size of microvilli; by contrast, progesterone, in addition to inducing secretory activity in non-ciliated cells, had a negative effect on oestradiol-dependent morphological characteristics of ciliated cells, causing a reduction in cell number and d

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Kiyma, Z., M. Hitit, C. Ozel, et al. "121 EXPRESSION OF HYALURONAN SYSTEM COMPONENTS IN THE EARLY PREGNANT OVINE ENDOMETRIUM." Reproduction, Fertility and Development 27, no. 1 (2015): 152. http://dx.doi.org/10.1071/rdv27n1ab121.

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Hyaluronan (HA; hyaluronic acid), a member of glycosaminoglycans (GAG) family, is the main polysaccharide and is expressed in almost all tissues including those of the reproductive tract. Three different hyaluronic acid-synthase (HAS) enzymes, HAS1, HAS2, and HAS3, synthesise HA. The action of HA depends on its molecular size and its cell surface receptor (CD44). Hyaluronidases (HYAL) are a group of enzymes, HYAL-1 and HYAL-2, that degrade HA. Roles of the HA system in reproductive events include oocyte maturation, fertilization, and implantation. It is also known that ovarian steroids, specif

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Mirando, MA, M. Uzumcu, KG Carnahan, and TE Ludwig. "A Role for Oxytocin during Luteolysis and Early Pregnancy in Swine." Reproduction in Domestic Animals 31, no. 3 (1996): 455–61. https://doi.org/10.1111/j.1439-0531.1996.tb00012.x.

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AbstractIn swine, episodic release of prostaglandin (PG) F2α is responsible for corpus luteum (CL) regression, but the stimulus for its secretion from the endometrium has not been established. We hypothesize that oxytocin (OT) acts through specific endometrial OT receptors (OTr) to activate the phosphoinositide (PI) signaling pathway, thereby stimulating pulsatile PGFF2α secretion which is luteolytic. When OT is administered to cyclic gilts during late diestrus (i.e., days 10‐16), interestrous interval is decreased. This effect is uterine‐dependent because OT does not promote CL regression in

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Burac, Mihaela, Natalia Corolcova, and Valentin Friptu. "Molecular characterization of the endometrium as a fertility-determining factor." Moldovan Medical Journal 63(1) (March 10, 2020): 39–43. https://doi.org/10.5281/zenodo.3685660.

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<strong>Background: </strong>Structural transformation of the endometrium during the menstrual cycle is a genetically determined process and is provided by complex molecular-biological interactions aimed at the onset and development of pregnancy. Sex steroid hormones play a key role in endometrial morphogenesis, which mediate or directly affect angiogenesis and immunogenesis. <strong>Conclusions: </strong>The primary function of the endometrium is to provide an immuno-privileged site for embryo implantation and to provide a nurturing environment for the fetus during pregnancy. T

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Gazizova, Gulnaz Kh, Alfiya G. Yashchuk, Anton V. Maslennikov, Liliana A. Dautova, and Gyuzel’ Yu Battalova. "Morphological features of the endometrium in patients with atrophic chronic endometritis and impaired hemodynamics." V.F.Snegirev Archives of Obstetrics and Gynecology 9, no. 4 (2022): 231–37. http://dx.doi.org/10.17816/2313-8726-2022-9-4-231-237.

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BACKGROUND: Chronic endometritis is a clinical and morphological syndrome in which, due to persistent endometrial damage to the endometrium by an infectious agent, multiple secondary morphofunctional changes occur that impair cyclic transformation and receptivity of the uterine mucosa. AIM: This study aimed to reveal morphological features of the endometrium in patients with atrophic chronic endometritis and impaired hemodynamics in the endometrium. MATERIALS AND METHODS: The study involved 86 female patients divided into two groups. Group 1 comprised 44 patients with chronic endom

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Gupta, Kanchan, Vijay Kumar Sirohi, Suparna Kumari, et al. "Sorcin is involved during embryo implantation via activating VEGF/PI3K/Akt pathway in mice." Journal of Molecular Endocrinology 60, no. 2 (2018): 119–32. http://dx.doi.org/10.1530/jme-17-0153.

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Our earlier studies have demonstrated the cyclic variation and also the altered expression of sorcin in endometrium during early-to-mid-secretory phase transition in women with unexplained infertility. The current study was undertaken to establish the functional role of sorcin in endometrial receptivity in mice. Results indicated that sorcin was highly expressed during the window of implantation in mice and functional blockage of sorcin caused significant reduction in number of implanted blastocyst. The receptivity markers (i.e.Integrin β3, HBEGF, IGFBP1, WNT4 and Cyclin E)) were found to be d

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Fernando, S. C., J. S. Buck, M. D. Ashworth, J. W. Ross, R. D. Geisert, and U. DeSilva. "Porcine endometrial and conceptus tissue kallikrein 1, 4, 11, and 14 gene expression." Reproduction 132, no. 6 (2006): 939–47. http://dx.doi.org/10.1530/rep.1.01013.

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Previous studies have suggested that the porcine endometrium may express several tissue kallikreins during the estrous cycle and early pregnancy. The present study investigated porcine endometrial and conceptus tissue kallikrein 1, 4, 11, and 14 mRNA expression during the estrous cycle and early pregnancy. Tissue kallikrein (KLK) gene expression was evaluated using quantitative RT-PCR and in situ hybridization. KLK1 expression was similar across the estrous cycle and early pregnancy, and localized to the endometrial luminal (L) and glandular (G) epithelium. KLK4 endometrial mRNA expression was

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Saut, João P. E., Gareth D. Healey, Alan M. Borges, and I. Martin Sheldon. "Ovarian steroids do not affect bovine endometrial cytokine or chemokine responses to Escherichia coli or LPS in vitro." REPRODUCTION 148, no. 6 (2014): 593–606. http://dx.doi.org/10.1530/rep-14-0230.

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The risk of bacterial infection of the endometrium causing uterine disease in cattle is increased in the progesterone-dominated luteal phase of the ovarian cycle, while oestrogens or oestrus are therapeutic or protective against disease. The first line of defence against bacteria, such as Escherichia coli that cause inflammation of the endometrium, is the innate immune system, which recognises bacterial lipopolysaccharide (LPS). This study tested the hypothesis that cyclic variation in ovarian hormone concentrations alters innate immune responses within the bovine endometrium. Ex vivo organ cu

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Lancheros-Buitrago, D. J., P. Rodriguez-Villamil, J. W. Gregory, et al. "50 Equine uterine fluid proteome on the fifth day after ovulation." Reproduction, Fertility and Development 31, no. 1 (2019): 151. http://dx.doi.org/10.1071/rdv31n1ab50.

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The characterisation of the uterine proteome before the entry of the embryo to the uterus is essential to know the factors involved in the physiological events of gestation. The objective of the study was to compare, by a proteomics approach, the uterine lumen of cyclic and inseminated mares on Day 5 after ovulation. Samples of endometrial secretion were collected over 2 cycles during Day 5 post-ovulation. The first cycle constituted the cyclic group (n=10), and in the following cycle, the same mares were inseminated and considered as the inseminated group (n=8). All samples were subjected to

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Geisert, RD, TN Pratt, FW Bazer, JS Mayes, and GH Watson. "Immunocytochemical localization and changes in endometrial progestin receptor protein during the porcine oestrous cycle and early pregnancy." Reproduction, Fertility and Development 6, no. 6 (1994): 749. http://dx.doi.org/10.1071/rd9940749.

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Changes of progesterone receptor (PR) protein and cellular localization in the endometrium were evaluated during the oestrous cycle and early pregnancy of the gilt. During the oestrous cycle, the concentration of total PR protein within the endometrium was highest on Days 0-5 and decreased on Day 10. The endometrial concentration of PR reached a nadir on Day 12 and this level was maintained throughout the remainder of the oestrous cycle (Day 18). In pregnant gilts, the concentration of endometrial PR protein from Day 10 to Day 18 was similar to that in cyclic gilts. Western blot analysis with

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Siddiqui, Rabia Parveen, Varsha Pandey, Sonal Chandrakar, and Vanita Bhaskar. "The range of endometrial pathologies in patients with abnormal uterine bleeding at a tertiary care center in central India." MGM Journal of Medical Sciences 11, no. 3 (2024): 420–28. http://dx.doi.org/10.4103/mgmj.mgmj_240_24.

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Abstract Background: Endometrial disorders are among the most common gynecological conditions globally. Abnormal uterine bleeding (AUB) refers to any irregularity in the timing, volume, or pattern of menstrual blood flow. This study investigates the histopathological spectrum of endometrial changes across various age groups in patients presenting with AUB as their primary symptom. Materials and Methods: The study analyzed 226 endometrial biopsies/specimens collected over two years from patients with AUB as the main complaint. These specimens were processed, and slides stained with hematoxylin

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Kluz, Natalia, Emilia Kowalczyk, Małgorzata Wasilewska, and Paulina Gil-Kulik. "Diagnostic Value and Molecular Function of MicroRNAs in Endometrial Diseases: A Systematic Review." Cancers 16, no. 13 (2024): 2416. http://dx.doi.org/10.3390/cancers16132416.

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The human endometrium experiences significant cyclic morphological and biochemical changes throughout the menstrual cycle to prepare for embryo implantation. These processes are meticulously regulated by ovarian steroids and various locally expressed genes, encompassing inflammatory reactions, apoptosis, cell proliferation, angiogenesis, differentiation (tissue formation), and tissue remodeling. MicroRNAs (miRNAs) have been recognized as crucial regulators of gene expression, with their altered expression being linked to the onset and progression of various disorders, including cancer. This re

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Tral, Tatiana G., Gulruchsor Kh Tolibova, and Igor Yu Kogan. "Immunohistochemical evaluation of apoptosis inducing factor in missed abortion after IVF." Pediatrician (St. Petersburg) 13, no. 3 (2022): 47–53. http://dx.doi.org/10.17816/ped13347-53.

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BACKGROUND: Apoptosis is involved both in the cyclic transformation and the functional activity of the endometrium during the menstrual cycle. Upon the onset of pregnancy, apoptosis is an important component of the placentation process. Moreover, changes in the apoptosis-inducing factor expression in the gravidar endometrium may lead to peculiarity both of trophoblast differentiation and the gestation course, regardless of the conception method. AIM: to study the expression of apoptosis-inducing factor in abortive material in non-developing pregnancy after IVF. MATERIALS AND METHOD

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Shen, Xue, Hua Duan, Sha Wang, Lu Gan, Qian Xu, and Jin-Jiao Li. "Decreased Expression of Cannabinoid Receptors in the Eutopic and Ectopic Endometrium of Patients with Adenomyosis." BioMed Research International 2019 (January 20, 2019): 1–8. http://dx.doi.org/10.1155/2019/5468954.

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Objective. Adenomyosis is a common gynecologic benign disease that may have a life-long negative impact on women. Previous studies have indicated that the endocannabinoid system may participate in the progress of endometriosis. Our research aims to analyze the expression patterns of the typical cannabinoid receptors (CB1 and CB2), the main constituents of the endocannabinoid system, in endometrial samples derived from patients diagnosed as adenomyosis or not. Methods. Eutopic and corresponding ectopic endometrium from 45 premenopausal women diagnosed as adenomyosis and normal endometrium from

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Iwase, Akira, Hisao Ando, Tetsuro Nagasaka, et al. "Neutral Endopeptidase Expressed by Decidualized Stromal Cells Suppresses Akt Phosphorylation and Deoxyribonucleic Acid Synthesis Induced by Endothelin-1 in Human Endometrium." Endocrinology 147, no. 11 (2006): 5153–59. http://dx.doi.org/10.1210/en.2006-0172.

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Endothelin-1 (ET-1) in human endometrium has been proposed to have a potential paracrine role, for its receptors are also present within this tissue. In addition, the expression of ET-1 varies during the menstrual cycle, and therefore, ET-1 may be involved in the cyclic change of the human endometrium, such as proliferation and decidualization. However, neither the inactivation of ET-1 in the endometrium nor the paracrine effect of ET-1 on endometrial cells has been determined. We investigated the production of ET-1 and the presence of neutral endopeptidase (NEP), which cleaves and inactivates

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Kengni, Junie Hurette Chansi, Isabelle St-Louis, Sophie Parent, Valérie Leblanc, Carl Shooner, and Eric Asselin. "Regulation of prostaglandin D synthase and prostacyclin synthase in the endometrium of cyclic, pregnant, and pseudopregnant rats and their regulation by sex steroids." Journal of Endocrinology 195, no. 2 (2007): 301–11. http://dx.doi.org/10.1677/joe-07-0353.

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Prostaglandins (PGs) are critical regulators of a number of reproductive processes. To date, the presence and regulation of PGS in the rat endometrium have not yet been described. The objective of the present study was to investigate the expression of PGD synthase (PGDS) and prostacyclin synthase (PGIS) in the endometrium. Endometrial proteins and tissues were collected from cyclic non-pregnant, pregnant, and steroid-induced pseudopregnant rats. PGIS and PGDS were detected in the endometrium of cyclic, pregnant, and pseudopregnant rats but were not influenced by the estrous cycle. During early

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Paudel, Deliya, and Himanshu Regmi. "Endometrial pattern in women with abnormal uterine bleeding attending a tertiary care centre of Kathmandu." Journal of Pathology of Nepal 14, no. 1 (2024): 2147–49. http://dx.doi.org/10.3126/jpn.v14i1.60327.

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Background: Abnormal uterine bleeding is one of the most common problems among pre and postmenopausal women. Abnormal uterine bleeding is diagnosed when there is a substantial change in frequency, duration, or amountof bleeding during or between periodsin the absence of any organic pathology. The study was perform to assess the endometrial causes of abnormal uterine bleeding and their incidence in different age groups. Materials and methods: It was a cross sectional and descriptive study carried out at a Manmohan medical College & hospital, over a period of two year from 13th April, 2020 t

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Sorokin, Yuriy Aleksandrovich. "Immunological features of chronic endometritis." Terapevt (General Physician), no. 1 (2022): 62–65. http://dx.doi.org/10.33920/med-12-2201-07.

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Chronic endometritis is a clinical and morphological syndrome with a complex of morphological and functional changes in the endometrium, leading to a violation of the physiological cyclic transformation and receptivity of endometrial tissues. The treatment of chronic endometritis requires special consideration. Despite the progress of pharmacotherapy, there are significant methodological and practical difficulties. Cavitated solutions, low-intensity ultrasound effects, and photochromotherapy increase the effectiveness of the treatment of chronic endometritis and female infertility.

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Ozkan, Zehra Sema, Hasan Cilgin, Remzi Atilgan, et al. "Investigation of Tenascin Expression in Endometriosis." ISRN Pathology 2012 (December 16, 2012): 1–5. http://dx.doi.org/10.5402/2012/873759.

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Objective. To evaluate the serum and tissue levels and local expression pattern of tenascin, a high molecular weight extracellular matrix protein, in eutopic and ectopic endometrium from patients with and without endometriosis and to compare the proliferative and secretory phase differences. Materials and Methods. Thirty women with endometriosis and fifteen women without endometriosis undergoing surgery for benign indications were included in the study. Serum and tissue levels and proliferative and secretory phase expression patterns of tenascin in the ectopic and eutopic endometrium were anal

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International, Journal of Medical Science and Innovative Research (IJMSIR). "Diagnostic Efficacy of Endometrial Aspiration Cytology with Histopathological Correlation." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 6 (2024): 08–14. https://doi.org/10.5281/zenodo.15449508.

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<strong>Abstract</strong> <strong>Introduction</strong>: Endometrial cytopathology is a powerful tool for the detection of a wide variety of benign atypias, inflammatory changes, and infectious organisms. It is also helpful for the cyto-hormonal evaluation of patients and the detection of endometrial malignancies. <strong>Aims</strong>: To assess the diagnostic accuracy of endometrial aspiration technique and to compare the cyto-morphology of aspirated smears with histopathology<sup> </sup> Materials and Methods:<em> </em>Endometrial aspiration was performed using Karman’s cannula in 100

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Roemer, K. L., S. L. Young, and R. F. Savaris. "Characterization of GAB1 Expression Over the Menstrual Cycle in Women With and Without Polycystic Ovarian Syndrome Provides a New Insight Into Its Pathophysiology." Journal of Clinical Endocrinology & Metabolism 99, no. 11 (2014): E2162—E2168. http://dx.doi.org/10.1210/jc.2014-2128.

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Context: In a previous microarray analysis, GRB2-associated binding protein 1 (GAB1), a docking protein closely related to the insulin receptor substrate, was down-regulated in endometrium of women with polycystic ovary syndrome (PCOS). Objective: The objective of the study was to characterize the cyclic expression of endometrial GAB1 in vivo in normal women and those with PCOS as well as investigate the possible mechanisms of endometrial regulation of GAB1 expression and action in vitro. Design: This was an experimental and case-control study. Setting: The study was conducted at a tertiary un

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Gregory, Christopher W., Elizabeth M. Wilson, K. B. C. Apparao, et al. "Steroid Receptor Coactivator Expression throughout the Menstrual Cycle in Normal and Abnormal Endometrium." Journal of Clinical Endocrinology & Metabolism 87, no. 6 (2002): 2960–66. http://dx.doi.org/10.1210/jcem.87.6.8572.

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The endometrium of reproductive aged women undergoes cyclic developmental changes in preparation for implantation in response to estrogen and progesterone. These steroids and their receptors are tightly regulated throughout the menstrual cycle, and their actions are facilitated by the presence of steroid receptor coactivators of the p160 family. In this study using immunohistochemistry and Western blot analysis, we characterize the expression patterns of three coactivators, steroid receptor coactivator-1, amplified in breast cancer-1 (AIB1), and transcriptional intermediary factor-2 in human e

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Pizzimenti, Cristina, Vincenzo Fiorentino, Chiara Ruggeri, et al. "Autophagy Involvement in Non-Neoplastic and Neoplastic Endometrial Pathology: The State of the Art with a Focus on Carcinoma." International Journal of Molecular Sciences 25, no. 22 (2024): 12118. http://dx.doi.org/10.3390/ijms252212118.

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Autophagy is a cellular process crucial for maintaining homeostasis by degrading damaged proteins and organelles. It is stimulated in response to stress, recycling nutrients and generating energy for cell survival. In normal endometrium, it suppresses tumorigenesis by preventing toxic accumulation and maintaining cellular homeostasis. It is involved in the cyclic remodelling of the endometrium during the menstrual cycle and contributes to decidualisation for successful pregnancy. Such a process is regulated by various signalling pathways, including PI3K/AKT/mTOR, AMPK/mTOR, and p53. Dysregulat

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Patil, Madhuri. "What is the Optimum Endometrium Needed for Implantation?" Fertility & Reproduction 05, no. 04 (2023): 290. http://dx.doi.org/10.1142/s2661318223741048.

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Implantation most critical step in reproduction. A complex process where blastocyst becomes intimately connected with maternal endometrium/decidua and requires; Competent embryo at blastocyst stage Receptive endometrium Synchronized dialogue between maternal and embryonic tissues Endometrial Changes for Implantation include architectural, morphological, cytochemical, molecular and genetic. These Changes Induce Endometrial receptivity, which is endometrial lining in a state of readiness for blastocyst implantation. It involves acquisition of adhesion ligands and loss of inhibitory components th

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