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Dissertations / Theses on the topic 'Cyclin C'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Greene, David. "Cyclin C and Cdk8 in 'Dictyostelium discoideum." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442460.

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2

Ponce, Jessica Marie. "Investigating the roles of cyclin C in the mammalian heart." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/7015.

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Although pathological alterations in gene expression and mitochondria function in response to cardiac ischemia are well recognized, the mechanisms driving these changes are incompletely understood. Nuclear to mitochondrial communication regulating gene expression and mitochondrial function is a critical process following cardiac ischemic injury. Here we determine that cyclin C, a component of the transcriptional regulator, Mediator complex, directly regulates cardiac and mitochondrial function by modifying mitochondrial fission. We tested the hypothesis that cyclin C has a binary function as a

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3

Dimova, Nevena Varbinova. "Defining the Ubiquitin and E2-Enzyme Requirements for APC/C-Mediated Degradation of Cyclin B1." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10401.

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Post-translational modification of proteins with ubiquitin regulates many aspects of cell physiology, including protein degradation. A uniform polyubiquitin chain that is linked through Lys48 has been widely accepted as central for recognition and destruction by the 26S proteasome. Work in more recent years has demonstrated that the repertoire of proteolytic signals may encompass chains of other linkage types, including Lys11-linked ubiquitin chains and short assemblies of mixed linkage. In this dissertation I examine whether catalysis mediated by the Anaphase-Promoting Complex/Cyclosome (APC/

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4

Höppner, Sabine. "Structure of the Mediator subunit Cyclin C and subunit interaction studies within the Mediator head module." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-46936.

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5

Zhang, Suyang. "Mechanism of APC/C activation and substrate specificity in mitosis." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275479.

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In eukaryotes, cell proliferation and cell cycle transitions are strictly controlled by the anaphase-promoting complex/cyclosome (APC/C). The APC/C is an E3 ubiquitin ligase that regulates chromatid segregation at the metaphase to anaphase transition, exit from mitosis and the establishment and maintenance of G1. The APC/C’s catalytic activity and substrate specificity are controlled by its interactions with two coactivators, Cdc20 and Cdh1. In contrast to Cdh1, APC/C activation by Cdc20 during mitosis requires hyper-phosphorylation of APC/C subunits by cyclin-dependent kinase (Cdk) and polo k

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6

Schneider, Elisabeth Veronika [Verfasser], Robert [Akademischer Betreuer] Huber, and Adelbert [Akademischer Betreuer] Bacher. "Structural and functional characterization of human protein kinases exemplified on the human cyclin-dependent kinase 8, cyclin C complex / Elisabeth Veronika Schneider. Gutachter: Robert Huber ; Adelbert Bacher. Betreuer: Robert Huber." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1035502852/34.

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7

Schneider, Elisabeth V. [Verfasser], Robert [Akademischer Betreuer] Huber, and Adelbert [Akademischer Betreuer] Bacher. "Structural and functional characterization of human protein kinases exemplified on the human cyclin-dependent kinase 8, cyclin C complex / Elisabeth Veronika Schneider. Gutachter: Robert Huber ; Adelbert Bacher. Betreuer: Robert Huber." München : Universitätsbibliothek der TU München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20120920-1108725-0-3.

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8

Desai, Shraddha R. "Role of Protein Kinase C-iota in Glioblastoma." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3070.

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The focus of this research was to investigate the role of protein kinase C-iota (PKC-é) in the regulation of Bad function, a pro-apoptotic member of the Bcl-2 family and Cdk7 function, a master cell cycle regulator in glioblastoma. The results were obtained from the human glial tumor derived cell lines, T98G and U87MG. In these cells, PKC-é co-localized and directly associated with Bad as shown by immunofluorescence, immunoprecipitation, and Western blotting. Furthermore, in-vitro kinase activity assay showed that PKC-é directly phosphorylated Bad at phospho specific residues, S112, S136 and

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9

Silva, Michael Santos. "Flow cytometric of c-FLIPl-mediated regulation of cell cycle and cell population size." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22487.

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Mestrado em Bioquímica - Bioquímica Clínica<br>c-FLIP é uma proteína conhecida pela sua capacidade de se ligar ao DISC, onde compete com a procaspase-8 pela interação com FADD. No entanto, existem evidências que a sua isoforma longa consegue regular também o ciclo celular e mecanismos de proliferação. Para além disso, a atividade de c-FLIPL pode ser controlada por fosforilação. Assim, o objetivo deste estudo é perceber como a fosforilação no resíduo de serina 227 nesta proteína afeta a proliferação e ciclo celular. Neste estudo, observamos que a sobre-expressão de c-FLIPL com uma mutação de se

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10

Roset, i. Huguet Ramon. "Study of the regulation and signalling of cdk2-Cyclin o complexes during apoptosis." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7199.

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The aim of this thesis is the characterization of a protein involved in apoptosis. Our group has identified an early step common to different forms of intrinsic apoptosis stimuli. This step requires de novo synthesis of a novel Cyclin, Cyclin O, that upon apoptosis induction in lymphoid cells forms active complexes, primarily with Cdk2. Cyclin O expression precedes glucocorticoid and gamma radiation-induced apoptosis in vivo in mouse thymus and its overexpression induces apoptosis in cultured cells. Knocking down the endogenous expression of Cyclin O by shRNA leads to the inhibition of glucoco

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11

Saturno, Juvaní Lago. "Análise imuno-histoquímica da Bcl-2, Bcl-6, c-Myc e ciclina D1 em linfomas de células B da região oral." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-06082014-144841/.

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Neste trabalho foram analisados 30 casos de linfomas de células B da região oral, fixados em solução de formaldeído e incluídos em parafina, através da técnica de imuno-histoquímica para as proteínas c-Myc, Bcl-2, Bcl-6 e ciclina D1. Dos casos analisados 40% foram positivos para a marcação para c-Myc, 33,3% para a marcação para ciclina D1, 83,3% para a marcação para Bcl-2 e 53,3% para a marcação para Bcl-6. Todos os casos foram diagnosticados como linfomas difusos de grandes células B, o subtipo de linfoma com a maior casuística. A análise destas proteínas é de fundamental importância para o d

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12

Nayak, Tania. "Investigations of the Functions of gamma-Tubulin in Cell Cycle Regulation in Aspergillus nidulans." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1218557154.

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13

Aburad, Arlindo Tadeu Teixeira. "\"Expressão das proteínas ciclina D1, c-jun e do retinoblastoma e pesquisa do HPV em carcinomas epidermóides bucais\"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-15032007-083003/.

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No Brasil, como no mundo, o carcinoma epidermóide bucal está entre os dez tipos mais comum de câncer e acomete mais de 13 mil pessoas por ano. Apesar de ser um sério problema devido a sua morbidade e mortalidade, alguns casos desta doença têm um comportamento biológico menos agressivo. A proteína ciclina D1, depois que forma complexos com as proteínas CDK4 e CDK6, tem como principal função fosforilar a proteína Retinoblastoma. Após sua fosforilação, a proteína libera um fator de transcrição, o E2F, que leva a célula à progressão da fase G1 para fase S do ciclo celular. A proteína c-jun, que fa

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14

Iyirhiaro, Grace O. "The Role of Cell Cycle Machinery in Ischemic Neuronal Death." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26230.

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Ischemic stroke occurs as a result of a lack or severe reduction of blood supply to the brain. Presently therapeutic interventions are limited and there is a need to develop new and efficacious stroke treatments. To this end, a great deal of research effort has been devoted to studying the potential molecular mechanisms involved in ischemic neuronal death. Correlative evidence demonstrated a paradoxical activation of the cell cycle machinery in ischemic neurons. The levels and activity of key cell cycle regulators including cyclin D1, Cdk2 and Cdk4 are upregulated following ischemic insults.

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15

Peres, Raquel Mary Rodrigues 1983. "Instabilidade genômica em neoplasias malignas da mama em função da concentração de alumínio intracelular : Genomic instability association with intracellular aluminum concentration in breast tumors." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310522.

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Orientador: Luis Otavio Zanatta Sarian<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-11-07T13:37:40Z (GMT). No. of bitstreams: 1 Peres_RaquelMaryRodrigues_D.pdf: 3497486 bytes, checksum: c509c5d08807f1a5bcd1b918eaf7d09d (MD5) Previous issue date: 2013<br>Resumo: Introdução: A hipótese de que os efeitos do alumínio em células humanas podem ter implicações clínicas tem sido levantada há algum tempo, especialmente no que concerne ao câncer de mama. As evidências laboratoriais mostrando altos níveis de alumínio nos teci

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16

Ong, Kai Li. "SNFing Glucose to PASs Mitochondrial Dysfunction: The Role of Two Sensory Protein Kinases in Metabolic Diseases." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8587.

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Mitochondria is no longer viewed as merely a powerhouse of the cell. It is now apparentthat mitochondria play a central role in signaling, maintaining cellular homeostasis and cell fate.Mitochondrial dysfunction has been linked to many human diseases caused by cellular metabolicderegulation, such as obesity, diabetes, neurodegenerative disease, cardiovascular disease andcancer. Eukaryotic organisms have evolved an efficient way in sensing, communicating andresponding to cellular stress and regulating mitochondrial activity correspondingly through acomplex network of intercommunicating protein

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17

Cederblad, Lena. "Aspects on Head and neck Cancer with special reference to Salivary Gland Tumours and Single Nucleotide Polymorphism." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-332192.

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A thesis on Head and neck cancer focusing on dose planning, salivary gland carcinoma and Single nucleotide polymorphism. For dose planning PET/CT (Positron emissions tomography/computed tomography) with tracer gave more precise information in comparison dose planning with CT. More primary tumours and metastases were found with the acetate tracer than with glucose tracer. Acetate PET/CT also showed larger volume of tumours attributed to lipid metabolism. In a retrospective study salivary gland cancer 5-year overall survival (OS) was 53 %. Salivary gland carcinoma consists of many histopathologi

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18

Barette, Caroline. "Régulation de l'expression de cycline C et études fonctionnelles du complexe cycline C-cdk8." Montpellier 2, 1999. http://www.theses.fr/1999MON20209.

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Le complexe cycline c-cdk8 peut s'associer, dans differents complexes plus larges, a la machinerie de transcription arn polymerase ii, depuis la levure jusqu'a l'homme. Si aucune evidence n'a ete apportee sur un role direct de ce complexe dans la regulation du cycle cellulaire, son implication dans le controle transcriptionnel est assez bien documentee chez la levure. Les travaux presentes ici permettent de montrer que, par des experiences de synchronisation, l'expression genique de cycline c est activee transitoirement par le serum et independamment du cycle cellulaire, dans des fibroblastes

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19

Mariaule, Gaëlle. "Accès original aux hétérocycles par la catalyse organométallique : développement de nouveaux inhibiteurs de kinases." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P612/document.

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Cette thèse est composée de deux parties distinctes ayant comme thématique commune, la synthèse d’hétérocycles via la catalyse organométallique.Nous nous sommes intéressés, dans un premier temps, à une voie de synthèse permettant un accès rapide au squelette tétrahydrocyclopenta[c]acridine. Ces composés polyfonctionnalisés sont obtenus très efficacement en seulement trois étapes dans des conditions particulièrement douces. L’étape clé de cette synthèse est une réaction de Pauson-Khand intramoléculaire catalysée au cobalt. Certains composés issus de la famille des tétrahydrocyclopenta[c]acridin

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20

Park, Ji S. "CYCLIC GMP: A SATIETY SIGNAL IN C. ELEGANS." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3851.

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Appetite control and satiety mechanisms help animals maintain energy homeostasis; however, these mechanisms can be misregulated, leading to overweight and obesity. Caenorhabditis elegans is an excellent model system to study appetite and satiety because of its conserved behavioral aspects of satiety and conserved molecular mechanisms. ASI senses nutrition and its activity is required for the behavioral state of satiety quiescence. The purpose of this thesis project was to elucidate the function of cGMP signaling in ASI by looking at behavioral effects from the pharmacological use of sildenafil

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21

Varma, Sreejith Jayasree. "Mimicking C-C bond forming reactions of core metabolism." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF038/document.

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Toutes les formes de vie assemblent et désassemblent continuellement des composés chimiques via un processus de consommation d'énergie appelé métabolisme. Le métabolisme est généralement modélisé en chimie et biologie par un cycle. Ce modèle dynamique traduit la transformation de composés de base en une cascade de produits appelés métabolites. Celui-ci est comparable à un ouragan à l’échelle moléculaire. De manière analogique et imagée un cyclone est constitué de deux éléments, l'air et l'eau, et transforme l’environnement qui l’entoure par un processus endothermique (consommateur d’énergie).

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22

Peter, Marion. "Aspects de la régulation de la kinase Cdc2-cycline B dans les ovocytes de Xénope." Montpellier 2, 2001. http://www.theses.fr/2001MON20115.

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23

Duff, Fraser John. "Synthesis of aza-C-disaccharides using a functionalised cyclic nitrone." Thesis, Heriot-Watt University, 1999. http://hdl.handle.net/10399/581.

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24

Mellon, Killian. "C-ERBB oncogenes and cell cycling in human bladder cancer." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333949.

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25

Omote, Masato. "Development of Asymmetric Syntheses Utilizing C, N-Cyclic Azomethine Imines." 京都大学 (Kyoto University), 2011. http://hdl.handle.net/2433/142393.

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26

Warren, Melissa. "Interactions between nitrogen fixation and methane cycling in boreal peat bogs." Thesis, Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53620.

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Microbial nitrogen (N2) fixation supplies important nitrogen inputs to boreal peatlands, extremely oligotrophic ecosystems dominated by Sphagnum mosses. In this study, we coupled major and trace nutrient analyses and rate measurements to characterize interactions between N2 fixation and CH4 cycling at the S1 peat bog in Marcell Experimental Forest and the Zim bog (Minnesota, USA). Total dissolved inorganic nitrogen (NO3-+NO2-+NH4+) and phosphate were both consistently < 2 μM in the porewater of surface peat, indicating severe nutrient limitation. While dissolved Fe was fairly abundant (18-35 m

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27

Preußer, Sebastian [Verfasser], and Ellen [Akademischer Betreuer] Kandeler. "Biological regulation of subsoil C-cycling / Sebastian Preußer ; Betreuer: Ellen Kandeler." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2020. http://d-nb.info/1202847889/34.

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28

Sweeney, Gary. "Protein kinase C isoforms : insulin signalling, cyclic amp metabolism and diabetes." Thesis, University of Glasgow, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306884.

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29

Smith, Graeme. "Degradation of the nanoparticulate Pt/C air cathode by cyclic thermammetry." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610273.

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30

Simm, Roger. "Characterization of c-di-GMP signalling in Salmonella typhimurium /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-417-4/.

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31

Loncle, Nicolas. "Rôles distincts des sous-unités du module CDK8 du complexe médiateur de la transcription au cours du développement de la drosophile." Toulouse 3, 2007. http://www.theses.fr/2007TOU30075.

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32

Latoscha, Andreas. "Cyclic di-adenosine monophosphate metabolism and functions in Streptomyces venezuelae." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22840.

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Lebewesen nutzen nukleotid-basierte sekundäre Botenstoffe um extra- und intrazelluläre Signale zur Induktion einer entsprechenden Zellantwort weiterzuleiten. Das zyklische Dinukleotid c-di-AMP steuert verschiedene physiologische Prozesse und ist für viele Bakterien unter bestimmten Bedingungen essentiell. Dieses Signalmolekül muss präzise reguliert werden, da seine Akkumulation oft toxisch ist. Diadenylatzyklasen mit einer DAC-Domäne synthetisieren c-di-AMP, welches von Phosphodiesterasen (PDE) mit DHH/DHHA1- oder HD-Domänen abgebaut wird. Streptomyceten sind im Boden lebende, Gram-positive A

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33

Anderson, Joanne W. "The Magdalen fresco cycles of the Trentino, Tyrol and Swiss Grisons, c.1300-c.1500." Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/3111/.

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This thesis presents and contextualises a distinct cluster of fresco cycles depicting the life of Mary Magdalen in the central-eastern Alpine regions of Trentino, Tyrol and the Swiss Grisons from the late middle ages to the early Renaissance. Located for the most part in the marginal rural parish ambit and reflecting the agenda of the local patron, these cycles offer an alternate manifestation of the popularity and relevence of a major saint at this time. As such my thesis is a corrective to the precedence placed on the role of the mendicant orders in the development and transmission of the Ma

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34

Cox, Martha E. (Martha Ellen). "C-terminal carboxylmethylation of the myelination-associated 2,́3-́cyclic nucleotide 3-́phosphodiesterase." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22727.

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Eukaryotic proteins with a carboxyl-terminal CXXX motif are modified by isoprenylation and subsequently processed by proteolysis of the three terminal amino acids and carboxylmethylation of the exposed cysteine residue. The myelination-associated 2$ sp prime$,3$ sp prime$-cyclic nucleotide 3$ sp prime$-phosphodiesterase (CNP) has a C-terminal CTII sequence and is isoprenylated; however, no examples of subsequent processing exist when a polar threonine is located adjacent to the cysteine. Here I show that CNP is capable of being carboxylmethylated in both insect cells and glioma cells. This pro

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35

GREGORY, KIMBERLY NICOLE. "SARCOPLASMIC RETICULUM CALCIUM CYCLING AND CARDIAC DISEASE." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1116008332.

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36

Reich, Blair Jesse Ellyn. "Cyanide-catalyzed C-C bond formation: synthesis of novel compounds, materials and ligands for homogeneous catalysis." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4987.

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Cyanide-catalyzed aldimine coupling was employed to synthesize compounds with 1,2-ene-diamine and ÃÂ±-imine-amine structural motifs: 1,2,N,N'- tetraphenyletheylene-1,2-diamine (13) and (+/-)-2,3-di-(2-hydroxyphenyl)-1,2- dihydroquinoxaline (17), respectively. Single crystal X-ray diffraction provided solidstate structures and density functional theory calculations were used to probe isomeric preferences within this and the related hydroxy-ketone/ene-diol system. The enediamine and imine-amine core structures were calculated to be essentially identical in energy. However, additional effects-su

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37

Sobolewski, Cyril. "Effets d'inhibiteurs de la cyclooxygénase-2 sur la prolifération et la survie de cellules cancéreuses hématopoïétiques." Thesis, Nancy 1, 2011. http://www.theses.fr/2011NAN10102/document.

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Les cyclooxygénases (COXs) sont une famille d'enzymes impliquées dans la biosynthèse des prostaglandines. COX-2 est la forme inductible qui est induite pendant l'inflammation et qui est surexprimée dans plusieurs cancers. Plusieurs évidences suggèrent que COX-2 joue un rôle dans la prolifération cellulaire et l'apoptose. Ces évidences concernent surtout les tumeurs solides et les mécanismes impliqués ne sont pas complètement connus et surtout pour les cancers d'origine hématopoïétique. Pour notre étude, nous avons étudié l'effet d'inhibiteurs de COX-2 (nimésulide, NS-398 et célécoxib) sur la p

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38

Verheijen, Hendricus. "Effects of allochthonous organic matter and iron on plankton community functioning and annual carbon cycling in a subarctic estuary under winter conditions." Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127179.

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High winter respiration has been observed in a subarctic estuary with high levels of organic matter inputs, while winter is generally thought to be a non-productive season. We constructed an oxygen and carbon budget of the system to validate the high respiration rate, including the resulting low production-to-respiration ratio, and to identify important carbon and energy sources. Measurement data of production and respiration parameters from running monitoring programs were used. Furthermore, we set up a microcosm experiment in order to study effects of iron increases by riverine organic matte

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39

Zirimwabagabo, Jean-Olivier. "Kinetic resolution of cyclic enol ethers by Pd-catalyzed [1,3] O-C rearrangement." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7105/.

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This thesis concerns the development of kinetic resolution of cyclic enol ethers utilizing a Pd-catalyzed [1,3] O-C rearrangement reaction. The required enol ethers were prepared from commercially available starting materials in good to excellent yields. The Pd-catalyzed [1,3] O-C rearrangement of these enol ethers in the presence of a chiral ligand proceeds smoothly via a kinetic resolution process returning remaining starting material with low to excellent levels of enantioselectivity. Enantiomerically enriched enol ethers were further transformed to a series of carbo- and heterocyclic produ

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40

Bamminger, Chris [Verfasser], and Ellen [Akademischer Betreuer] Kandeler. "Biochar amendment for C sequestration in a temperate agroecosystem : implications for microbial C- and N-cycling / Chris Bamminger ; Betreuer: Ellen Kandeler." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2018. http://d-nb.info/1155824075/34.

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Mizin, Kavita Lakshmi. "C and N Cycling Dynamics and Microbial Community Composition in High Tunnel Production Systems." UKnowledge, 2014. http://uknowledge.uky.edu/pss_etds/48.

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Across the United States, high tunnels are used as a means of season extension and control over climatic variability in fruit and vegetable production. However, high tunnel systems are an intensive form of agricultural production which may compromise soil and crop quality over time. This study examined the effects of the varying environmental conditions, created in two types of tunnel system, movable and stationary, on the flow of nitrogen from amendment to plant and impact on crop and soil quality parameters. The way nutrients cycled through these systems was different and the nutrient treatm

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42

McCloskey, Margaret Ann. "Plastic instability of platinum modified and unmodified aluminide coatings during 1100 C cyclic testing." Thesis, Monterey, California: U.S. Naval Postgraduate School, 1987. http://hdl.handle.net/10945/22420.

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43

Yonow, T. "Life-cycle adaptations of some Diptera inhabiting tropical rain pools." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381527.

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44

Pène, Véronique. "Chronologie et rôles des clivages de la protéine C dans le cycle du virus de l'hépatite C." Paris 6, 2007. http://www.theses.fr/2007PA066486.

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La forme p23 de la protéine C du VHC est libérée de la polyprotéine virale au site C/E1 par clivage par la signal peptidase (SP) cellulaire, mais reste ancrée dans la membrane du RE par le peptide signal à la jonction C/E1. La p21 est issue du clivage intramembranaire de ce peptide signal par la signal-peptide-peptidase (SPP). Le but de ce travail a été de déterminer le rôle de ces clivages dans le cycle infectieux du virus. Le clivage de la protéine C par la SP est dans tous les cas un préalable au clivage par la SPP. D’autre part, la morphogenèse du VHC semble favorisée lorsque la protéine C

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Farao, Al Cerillio. "Synthetic strategies for denatured cytochrome-c analogues towards analytical reporting of NOx species." University of the Western Cape, 2019. http://hdl.handle.net/11394/7012.

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Philosophiae Doctor - PhD<br>Nitric oxide (NO) plays a key role as biological messenger in the biological system, however detection and quantification thereof has always posed significant problems. NOx is a principal constituent of air pollutants. There are seven oxides of nitrogen of which N2O, NO and NO2 are most important. NO is a free radical and reacts extremely fast with oxygen, peroxides and superoxides. It’s these reactions which are responsible for NO’s fleeting existence. The specific detection and quantification of NO still remains challenging. Most techniques rely on the measureme

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Huang, Wen-Jye. "Investigation of the benefits of multi-chain Loran-C and hybrid GPS/Loran-C positioning." Ohio : Ohio University, 1997. http://www.ohiolink.edu/etd/view.cgi?ohiou1177438222.

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Lavoisier-Gallo, Tania. "C-C versus C-O-diakylation d'anions stabilisés : nouvelles réactions anioniques pour la synthèse de systèmes bicycliques pontés, de cycles moyens et d'éthers d'énol fonctionnalisés." Aix-Marseille 3, 1996. http://www.theses.fr/1996AIX30119.

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Au cours de ce travail, nous avons developpe de nouvelles reactions domino anioniques, basees sur la reactivite d'anions stabilises, dans le but de construire stereoselectivement des systemes bicycliques pontes, des cycles moyens et des ethers d'enol cycliques. L'etude detaillee de la reaction de carbocyclisation, entre les cycloalkanones ,'-dicarbonylees et les dihalogenures de stereochimie apparentee (z), a montre l'efficacite de cette approche pour la construction de systemes bicycliques pontes, intermediaires de synthese particulierement attrayants pour l'acces aux cycloheptanes ou aux cyc

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Wieczysty, Martin David. "C-H functionalisation of 2-aryl cyclic 1,3-dicarbonyl compounds ; Enantioselective Rh(I)-catalysed cyclisation of arylboron compounds onto ketones." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/18741.

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1. C–H Functionalisation of 2 Aryl Cyclic 1,3-Dicarbonyl Compounds Two enolate-directed C–H functionalisation protocols have been developed using 2-aryl cyclic 1,3-dicarbonyl compounds as substrates. Reactions with activated alkenes, under ruthenium or palladium catalysis produced benzopyrans in most cases, in moderate to good yield. Alternatively, an oxidative annulation of 2-aryl cyclic 1.3-dicarbonyls with 1,3-enynes was facilitated under rhodium catalysis, forming functionalised spiroindene structures in most cases, in generally good yields and high regioselectivity. During the investigati

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Hurley, Nicole Elizabeth. "Modulating the Functional Contributions of c-Myc to the Human Endothelial Cell Cyclic Strain Response." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19822.

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With each heartbeat, major arteries experience circumferential expansion due to internal pressure changes. This pulsatile force is called cyclic strain and has been implicated in playing a pivotal role in the genetic regulation of vascular physiology and pathology. This dissertation investigates the hypothesis that in human umbilical vein endothelial cells (HUVEC), pathological levels of cyclic strain activate the c-Myc promoter, leading to c-Myc transcription and downstream gene induction. To determine expression and time-dependency of c-Myc in HUVEC, mRNA and protein expression of c-My

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Joo, Sang Hoon. "Synthesis and screening of support-bound combinatorial cyclic peptide and free C-terminal peptide libraries." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1195561420.

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