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Dissertations / Theses on the topic 'Cyclodextrin Complexation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Abdo, Ahmad M. "Parameters influencing complexation of some acidic drugs in aqueous cyclodextrin solutions." Thesis, Lancaster University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418460.

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2

Crevel, Dorian. "Utilisation de la chimie supramoléculaire pour la synthèse d'édifices nanoporeux appliquée à la complexation de molécules d'intérêts : du vivant à l'énergie." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF092.

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Cette thèse traite du développement et de l'optimisation de la synthèse de nanotubes d'α-cyclodextrine (NTs), et plus particulièrement sur l'obtention d'une large gamme de longueurs, notamment à partir de chaîne de poly(éthylène glycol) (POE) de très haute masse molaire (>100k g.mol⁻¹). La formation de ces édifices a été réalisée grâce à l'optimisation des quatre étapes successives de synthèse dont : la fonctionnalisation des différentes masses molaires de polymère avec des fonctions méthacrylate, la synthèse des pseudopolyrotaxanes et polyrotaxanes correspondants afin de mener à bien la sy

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3

au, pmenon1@optusnet com, and Kathleen Ilona Menon. "Assessment of the Antiprotozoal Activity of some Tubulin Inhibitors Following Cyclodextrin Complexation." Murdoch University, 2002. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20040820.133836.

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The purpose of the present study was to evaluate the potential usefulness of tubulin inhibitors when complexed with hydroxypropyl-â-cyclodextrin (ÇPâCD) against a range of protozoan parasites. This approach involved investigations into the complexation of these drugs with ÇPâCD, and subsequent investigations of these drugs and their complexes in regard to cytotoxicity, pharmacokinetics, in vitro efficacy against Giardia, Cryptosporidium and rodent malaria (Plasmodium chabaudi), and their in vivo efficacy against Giardia and malaria. Albendazole (ABZ) is a benzimidazole carbamate with a broad

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4

Menon, Kathleen Ilona. "Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation." Menon, Kathleen Ilona (2002) Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation. PhD thesis, Murdoch University, 2002. http://researchrepository.murdoch.edu.au/201/.

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The purpose of the present study was to evaluate the potential usefulness of tubulin inhibitors when complexed with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) against a range of protozoan parasites. This approach involved investigations into the complexation of these drugs with HP-beta-CD, and subsequent investigations of these drugs and their complexes in regard to cytotoxicity, pharmacokinetics, in vitro efficacy against Giardia, Cryptosporidium and rodent malaria (Plasmodium chabaudi), and their in vivo efficacy against Giardia and malaria. Albendazole (ABZ) is a benzimidazole carbamat

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5

Sala, Andrea. "Supramolecular derivatisation of bioactive molecules via co-crystallization and cyclodextrin inclusion complexation." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29711.

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The objective of this study was to modify the physicochemical properties of two common drugs via supramolecular derivatization. Sulfasalazine is a powerful anti-inflammatory drug and fluconazole has a strong antibacterial and antifungal activity. The common feature is their very low solubility in water. Cyclodextrin inclusion complexation and co-crystallization were carried out with the aim of ultimately improving the bioavailability of both drugs. Each new crystal phase isolated was analysed using X-ray diffraction, thermal and spectroscopic techniques. Sulfasalazine presents two tautomeric f

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6

Menon, Kathleen I. "Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation." Thesis, Menon, Kathleen I. (2002) Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation. PhD thesis, Murdoch University, 2002. https://researchrepository.murdoch.edu.au/id/eprint/201/.

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The purpose of the present study was to evaluate the potential usefulness of tubulin inhibitors when complexed with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) against a range of protozoan parasites. This approach involved investigations into the complexation of these drugs with HP-beta-CD, and subsequent investigations of these drugs and their complexes in regard to cytotoxicity, pharmacokinetics, in vitro efficacy against Giardia, Cryptosporidium and rodent malaria (Plasmodium chabaudi), and their in vivo efficacy against Giardia and malaria. Albendazole (ABZ) is a benzimidazole carbamat

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7

Menon, Kathleen I. "Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation." Access via Murdoch University Digital Theses Project, 2002. http://wwwlib.murdoch.edu.au/adt/admin/view/adt-MU20040820.133836.

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8

Jarand, Curtis William. "Complexation of Organic Guests and Coordination of Metal Ions by Cyclodextrins: Role of Cyclodextrins in Metal-Guest Interactions." ScholarWorks@UNO, 2011. http://scholarworks.uno.edu/td/1319.

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Nitroaromatic explosives, such as trinitrotoluene (TNT), are of particular environmental concern due to their recalcitrance in soils and their potent toxicity and mutagenicity to both aquatic and mammalian species. TNT was the most widely used military explosive through the era encompassing both the First and Second World Wars. As a result, there is widespread contamination of soils by TNT around weapons manufacture, testing, and disposal facilities. Fenton chemistry (ferrous ion catalyzed generation of hydroxyl radicals) has shown utility in the remediation of TNT in soils but it suffers from

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9

Maurel, Vaughan Jean. "Beneficiation of selected pesticides and an antihyperlipidemic agent via cyclodextrin complexation and co-crystallization." Doctoral thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/22911.

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The applications of many bioactive molecules are limited by their undesirable physicochemical properties, such as poor aqueous solubility and low thermal stability. The agrochemicals methyl- 2,5-dichlorobenzoate (fungicide, DCB) and fenthion (insecticide), as well as the medicinal compound acipimox (lipid-lowering agent) were selected for study in this context. The cyclodextrin (CD) complexes γ-CD/DCB, 2,6-dimethylated-β-CD/DCB, β-CD/fenthion, permethylated α-CD/fenthion and permethylated β-CD/fenthion, were synthesised. 1H-NMR spectroscopy, thermogravimetric analysis (TGA), differential scann

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10

Eteer, Shahrazad A. "The physical chemistry of corticosteroid-cyclodextrin complexes: The Host-guest Chemistry of Corticosteroid and Cyclodextrin Systems Elucidated with NMR and Applied to Novel Surface-decorated Surface Enhanced Raman Spectroscopic Probes." Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17379.

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Inhaled corticosteroids (ICS) are used to address inflammatory illnesses including asthma and COPD, with delivery commonly achieved using pressurised metered dose inhalers (pMDI). Hydrofluoroalkanes (HFAs) have been introduced as an alternative propellant to chlorofluorocarbons (CFCs) to reduce their environmental impact. However, the thermodynamic properties of HFAs are poorly understood and are different to those of CFCs. It is essential, therefore, to characterise the drugs and excipients used in HFA inhalers in order to obtain a comprehensive understanding of the device performance and the

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11

Madison, Phillip Holland IV. "Carbohydrate Mediation of Aqueous Polymerizations: Cyclodextrin Mediation of Aqueous Polymerizations of Methacrylates." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/33786.

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Cyclodextrin mediation offers a unique mechanism with the potential for interesting control of reaction parameters. Cyclodextrin mediation of hydrophobic monomers may offer desirable kinetics over conventional free radical polymerizations, and it has been shown in this work that cyclodextrin mediation facilitates polymerization of hydrophobic monomers in aqueous solution and in ethylene glycol. It also may be a facile method for controlling relative reactivity of comonomer mixtures. In addition, complexation of cyclodextrin with guest molecules has been utilized in selective synthesis wher

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12

Taylor, Sandra Nichole. "Cyclodextrin complexation of tetrachloroethylene, influence of binding constants on solubility and degradation by zero-valent iron." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2002. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ65648.pdf.

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13

Krait, Sulaiman [Verfasser], Gerhard [Gutachter] Scriba, Oliver [Gutachter] Werz, and Schepdael Ann [Gutachter] Van. "Capillary electrophoresis methods for chiral drug analysis and cyclodextrin-guest complexation mechanisms / Sulaiman Krait ; Gutachter: Gerhard Scriba, Oliver Werz, Ann Van Schepdael." Jena : Friedrich-Schiller-Universität Jena, 2021. http://d-nb.info/123135657X/34.

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14

Guedes, Luciana de Souza 1975. "Encapsulação e caracterização do fármaco imunomodulador Imiquimod em ß-ciclodextrina." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250350.

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Orientador: Francisco Benedito Teixeira Pessine<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-26T03:10:58Z (GMT). No. of bitstreams: 1 Guedes_LucianadeSouza_M.pdf: 5716470 bytes, checksum: 363ce3e7be504393ef2dcd6d349ed421 (MD5) Previous issue date: 2014<br>Resumo: O Imiquimod é um fármaco com propriedades imunomodulatórias, disponível na forma de creme para tratamento tópico de certas patologias da pele como carcinoma basocelular e ceratose actínica. O contato direto do medicamento com a pele pode causar desconforto

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15

Schmidt, Bernhard Volkmar Konrad Jakob [Verfasser], and C. [Akademischer Betreuer] Barner-Kowollik. "Novel Macromolecular Architectures via a Combination of Cyclodextrin Host/Guest Complexation and RAFT Polymerizatio / Bernhard Volkmar Konrad Jakob Schmidt. Betreuer: C. Barner-Kowollik." Karlsruhe : KIT-Bibliothek, 2013. http://d-nb.info/1041665598/34.

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16

Schmidt, Bernhard V. K. J. [Verfasser], and C. [Akademischer Betreuer] Barner-Kowollik. "Novel Macromolecular Architectures via a Combination of Cyclodextrin Host/Guest Complexation and RAFT Polymerizatio / Bernhard Volkmar Konrad Jakob Schmidt. Betreuer: C. Barner-Kowollik." Karlsruhe : KIT-Bibliothek, 2013. http://nbn-resolving.de/urn:nbn:de:swb:90-363894.

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17

Lainé, Descamps Valérie. "Synthèse de dérivés monoramifiés du cyclomaltoheptaose : étude de leurs propriétés d'inclusion par spectroscopie de résonance magnétique nucléaire : application à la solubilisation de substances d'intéret pharmacologique." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10066.

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Les cyclodextrines presentent la particularite d'inclure, dans leur cavite hydrophobe, des molecules insolubles dans l'eau. Or, certains antithrombotiques, insolubles dans les milieux aqueux, ne peuvent etre administres par voie parenterale. Notre objectif etait la solubilisation de ces composes par formation de complexes d'inclusion avec des derives du cyclomaltoheptaose. Nous avons synthetise des composes monoramifies en c-6 par des groupements de type thioglycosyle dans le but d'ameliorer la solubilite dans l'eau de la cyclodextrine d'origine tout en diminuant son pouvoir hemolytique. Les c

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18

Quillet, Anne. "Complexation de molécules antitumorales par des cyclodextrines." Paris 5, 1994. http://www.theses.fr/1994PA05P244.

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19

Ndong, ntoutoume Gautier mark arthur. "Elaboration des nanocristaux de cellulose fonctionnalisés pour la vectorisation d’agents anticancéreux et pour la transfection de gènes." Thesis, Limoges, 2015. http://www.theses.fr/2015LIMO0126/document.

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La vectorisation et le ciblage d’agents anticancéreux représentent des axes de recherche majeurs au sein du LCSN. En effet, la plupart des molécules actives utilisées en thérapie anticancéreuse sont peu sélectives des tumeurs et sont toxiques pour les cellules saines. L’élaboration de nanobiomatériaux aptes à cibler spécifiquement les tumeurs par effet EPR mais également capables de les détruire par l’action de la drogue transportée s’avère capital. Le nanovecteur utilisé est élaboré à partir des nanocristaux de cellulose (CNCx) issus de l’hydrolyse acide du coton. Une première approche a cons

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20

Mokhtar, Mohd Noriznan. "Biocatalytic Production, Preparation and Characterization of Large-ring Cyclodextrins." Doctoral thesis, Universitätsbibliothek Chemnitz, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200900431.

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Cyclodextrins (CD) are cyclic oligosaccharides composed of six to more than sixty glucose units. Large-ring cyclodextrins (LR-CD) are novel CD comprised of more than eight glucose units with cavity structures and sizes different from that of commercially available CD<sub>6</sub> – CD<sub>8</sub>. LR-CD may offer unique molecular recognition properties and can be produced biocatalytically from starch using cyclodextrin glucanotransferase (CGTase, E.C. 2.4.1.19) in a short reaction time. LR-CD were isolated from glucose, CD<sub>6</sub> – CD<sub>8</sub> and other compounds by complexation of CD<s

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21

Lee, Yann-Huei Phillip Ramapuram Jayachandra B. "Inclusion complexation of Gefitinib with cyclodextrins." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SUMMER/Pharmacal_Sciences/Thesis/Lee_Yann-huei_47.pdf.

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22

Mesguiche, Florence. "Interactions des cyclodextrines avec des composés chiraux : application à la complexation de phéromones." Paris 5, 1994. http://www.theses.fr/1994PA05P025.

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23

HETTLER, ODILE. "Modes de fixation de molecules actives au sein de cyclodextrines." Strasbourg 1, 1990. http://www.theses.fr/1990STR15025.

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24

Murphy, Robert Scott. "Photophysical studies on the dynamics of guest complexation with cyclodextrins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0017/NQ47292.pdf.

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25

Jeulin, Hélène. "Impact virologique et pharmacologique de la complexation de la ribavirine aux cyclodextrines sur un modèle animal d'encéphalite rougeoleuse." Thesis, Nancy 1, 2008. http://www.theses.fr/2008NAN10117/document.

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La ribavirine est un agent antiviral à large spectre efficace in vitro contre de nombreux virus à ARN dont certains sont responsables d'encéphalites. In vivo la mauvaise diffusion de cet analogue nucléosidique au niveau de la barrière hémato-encéphalique, limite son efficacité dans le traitement des encéphalites virales. Des études antérieures ont montré la capacité des cyclodextrines natives à former des complexes d’inclusion avec la ribavirine et l’amélioration de l’activité antivirale de la ribavirine in vitro lorsque celle-ci est complexée à l’alpha- ou la bêta-cyclodextrine. Le bénéfice d

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26

Hutin, Séverine. "Recherche de conditions d'optimisation de la complexation d'actifs avec des cyclodextrines en milieu semi-solide, de la préformulation à l'étude de faisabilité industrielle." Paris 11, 2005. http://www.theses.fr/2005PA114843.

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L’objectif de ces travaux est de completer l’état des connaissances concernant la complexation d’actifs avec des cyclodextrines. Une approche rationnelle statistique par le biais de plans d’expériences est utilize de manière à comprendre précisemment la relation entre les variables de procédé et les réponses associées. Des modèles mathématiques validés sont proposes pour décrire les relations entre la solubilité, les besoins energétiques requis par la complexation et une combinaison de paramètres relatifs aux conditions opératoires comme la vitesse de rotation des poles , la teneur en eau et l

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27

Charbonnier, Florence. "Synthèses, études structurales et propriétés de complexation d'Ureido-oligosaccharides supramoléculaires." Nancy 1, 1999. http://www.theses.fr/1999NAN12008.

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28

Smith, Vincent Joseph. "Complexation between cyclodextrins and phenylurea herbicides in solution and in the solid state." Doctoral thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/12151.

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Includes abstract.<br>Includes bibliographical references.<br>The author undertook the preparation of cyclodextrin inclusion complexes of four phenylurea herbicides (metobromuron, monolinuron, monuron and fenuron) using the kneading and co-precipitation methods in the solid state while also determining complex formation of the same phenylureas in solution with selected cyclodextrins. The kneading experiments were carried out first to determine whether the phenylureas would complex in the solid-state. The phenylureas were then subjected to complexation by means of co-precipitation under differe

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29

Fontanay, Stéphane. "Complexation de triterpènes pentacycliques par des cyclodextrines : caractérisations physicochimiques et activités biologiques." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0210/document.

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Le manque de thérapies innovantes en chimiothérapie humaine incite la communauté scientifique à s'intéresser à de nouvelles sources de composés bioactifs. Nous pouvons citer les métabolites secondaires de plantes, auxquels appartiennent les acides hydroxy pentacycliques triterpénoiques (AHPTs) et plus particulièrement les Acides Ursolique (AU), Oléanolique (AO) et Bétulinique (AB). Ces molécules font l'objet de nombreuses études qui tendent à démontrer leurs propriétés : anti-infectieuses, anticancéreuses, antiprolifératives, anti-inflammatoires, hépatoprotectrices. Le principal obstacle à leu

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30

Lee, Lok Yan. "Study of the photodegradation and photostability of anti-cancer drugs in different media towards the development of both new actinometers and liquid formulations." Thesis, De Montfort University, 2016. http://hdl.handle.net/2086/12188.

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This study aims at tackling some of the problems often encountered in photostability testing and liquid formulation development. Three anti-cancer drugs will be employed as models; Dacarbazine (DBZ) has well established photostability issues, Axitinib (AXI) and Sunitinib (SUT) are two new drugs only commercially available in solid dosage forms. In ethanol, the photokinetics of these drugs were well described by the newly proposed Φ-order kinetic mathematical model. This has confirmed the photoreversible character of AXI and SUT’s and unimolecular photoreaction of DBZ’s photodegradations. Also,

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31

Jeulin, Hélène Kedzierewicz Francine. "Impact virologique et pharmacologique de la complexation de la ribavirine aux cyclodextrines sur un modèle animal d'encéphalite rougeoleuse." S. l. : Nancy 1, 2008. http://www.scd.uhp-nancy.fr/docnum/SCD_T_2008_0117_JEULIN.pdf.

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32

Scondo, Alexandre. "La réaction phosphine imide en milieu CO2 supercritique." Thesis, Vandoeuvre-les-Nancy, INPL, 2008. http://www.theses.fr/2008INPL077N/document.

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Dans l'objectif de proposer un procédé de substitution du phosgène dans la production des isocyanates et de leurs dérivés, nous avons consacré ce travail à l'étude de la réaction phosphine imide dans le CO2 supercritique. Dans ce cadre, nous avons défini une réaction standard et nous avons étudié l'influence des paramètres opératoires sur la cinétique de cette réaction dans le CO2 grâce à un réacteur haute pression de 100 ml. Les analyses des échantillons obtenus ont été réalisées par chromatographie en phase liquide. Ces observations nous ont permis de développer un modèle cinétique du premie

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33

Moustoifa, El-Farouck. "Nouveaux outils moléculaires de diagnostic des étapes invasives des cancers." Thesis, Bordeaux 1, 2010. http://www.theses.fr/2010BOR14055/document.

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Les métalloprotéases de la matrice extracellulaire (MMPs) sont une famille d’enzymes responsables de la dégradation de la matrice extracellulaire. Elles jouent un rôle important à tous les stades du développement tumoral, de la prolifération des cellules cancéreuses à l’émission de métastases. Elles sont donc une cible biologique de choix pour contrôler ou imager les processus tumoraux. Dans le travail présenté, nous avons développé de nouveaux substrats fluorescents sélectifs et spécifiques des MMPs, qui ont permis de suivre l’activité protéolytique de ces enzymes. Ces substrats sont stables

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34

POPPING, BARBARA, and Bernard Sébille. "Immobilisation de cavites beta-cyclodextrine sur un polyelectrolyte. Relation conformation - proprietes de complexation. Adsorption sur des particules colloidales." Paris 6, 1993. http://www.theses.fr/1993PA066210.

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Des polymeres lineaires hydrosolubles (pvi-b-cd) contenant entre 14 et 70 % en poids de cavites beta-cyclodextrine (b-cd) ont ete prepares par greffage d'un derive reactif de b-cd sur le polyvinylimidazole (pvi). La conformation des pvi-b-cd en solution a ete etudiee par viscosimetrie et diffusion de la lumiere. Le caractere polyelectrolyte du squelette pvi donne aux polymeres une conformation expansee en milieu acide. La neutralisation s'accompagne d'une contraction de la pelote macromoleculaire, celle-ci etant d'autant plus compacte que les polymeres contiennent de b-cd. Ceci a ete attribue

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35

Bonnet, Célia. "Complexation des cations lanthanides trivalents par des ligands d'origine biologique pour l'IRM : structure, thermodynamique et méthodes." Phd thesis, Université Joseph Fourier (Grenoble), 2006. http://tel.archives-ouvertes.fr/tel-00089144.

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La complexation des ions lanthanides(III) par de nouveaux ligands dont la sphère de coordination oxygénée est montée sur une plateforme à base d'unités sucres ou acides aminés est étudiée. Malgré des masses moléculaires relativement faibles, ces complexes induisent des relaxivités élevées inattendues, en particulier à haut champ.<br />Les ligands ACX et BCX, dérivés acides d'Α- et Β-cyclodextrines modifiées, forment des complexes mono et bimétalliques avec les Ln(III). Les complexes LnACX ou LnBCX ont des affinités similaires à celle de ligands triacides. La structure à l'état solide du comple

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36

Bistri, Olivia. "Synthèses de motifs inédits cyclodextrines polydifférenciées : nouvelles méthodologies régiosélectives et application à la réticulation de biopolymères." Paris 6, 2006. http://www.theses.fr/2006PA066522.

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Les cyclodextrines sont des macrocycles concaves suscitant un intérêt croissant. La réaction de bis-dé-O-benzylation des alpha- et bêta-cyclodextrines perbenzylées par l’hydrure de diisobutylaluminium et la compréhension précise de son mécanisme ont permis d’accéder régiosélectivement à des alpha-cyclodextrines tri- et tétradifférenciées, ainsi qu’à des bêta-cyclodextrines tridifférenciées. La structure des régioisomères obtenus sélectivement a été entièrement élucidée et une explication de la régiosélectivité a été proposée en fonction de la géométrie du macrocycle considéré. Les structures o

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37

Grandeury, Arnaud. "Complexes supramoléculaires cristallisés chiraux de type hôte-invité avec des cyclodextrines perméthylées : Extension à la complexation d'un inhibiteur enzymatique." Rouen, 2004. http://www.theses.fr/2004ROUES044.

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Cette étude porte sur la compréhension des mécanismes fins de complexion lors d'associations supramoléculaires de type hôte-invité. L'utilisation d'une méthodologie originale, systématique, et multidisciplinaire a conduit à mieux cerner les facteurs impliqués dans la reconnaissance moléculaire et la complexation stéréosélective. Ainsi, le choix de molécules invitées, organisées en séries homologues, a permis d'étudier l'influence de la variation d'un seul paramètre moléculaire sur les modes d'inclusion et d'empilement. Une partie du projet concerne l'étude de la stéréosélectivité, des modes d'

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38

Beeson, John Christopher. "Part 1. Synthesis of novel duplex cyclodextrins and investigations of their catalytic and fluorescence properties. : Part 2. Pi-complexation induced by multiple hydrogen bonding in an organic hexammide /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487844485898676.

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39

Krajian, Hour. "Les liquides ioniques : nouveaux milieux pour les techniques électrocinétiques miniaturisées ? Applications." Rouen, 2008. http://www.theses.fr/2008ROUES037.

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Les recherches présentées dans ce mémoire s’inscrivent dans l’application de la « Chimie Verte » en Sciences Séparatives. En effet, les Liquides Ioniques représentent une nouvelle génération dans la famille des «solvants verts» avec leurs propriétés physico-chimiques uniques et ils apparaissant particulièrement bien adaptés aux techniques électrocinétiques. Ainsi, nous nous sommes proposés de tester les potentialités de Liquides Ioniques originaux à base respectivement de phénylcholine et d’éthylcholine comme des nouveaux milieux dans ce contexte par l’Electrophorèse Capillaire. Deux thématiqu

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Pham, Duc-Truc. "Beta-cyclodextrin modification and host-guest complexation." 2008. http://hdl.handle.net/2440/57975.

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A series of five linked β-cyclodextrin (βCD) dimers N,N-bis(6 [superscript]A-deoxy-6[superscript]A-β-cyclodextrinyl)-succinamide, 66βCD₂su, N-((2[superscript]A S,3 [superscript]A S)-3 [superscript]A-deoxy-3 [superscript]A-β-cyclodextrinyl)-N’-(6 [superscript]A-deoxy-6 [superscript]A -β-cyclodextrinyl)-urea, 36βCD₂su, N,N-bis((2 [superscript]A S,3 [superscript]A S)-3 [superscript]A -deoxy-3 [superscript]A-β-cyclodextrinyl)-succinamide, 33βCD₂su, N,N-bis(6[superscript]A-deoxy-6[superscript]A-β-cyclodextrinyl)-urea, 66βCD₂ur, and N-((2 [superscript]A S,3 [superscript]A S)-3 [superscript]A-deoxy-3

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Hu, Chien-Ming, and 胡健民. "Structure-solubility relationships among inclusion complexation of hydroxypropyl-��-cyclodextrin with bicyclic drugs." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/55679629840822951724.

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碩士<br>台北醫學院<br>藥學研究所<br>85<br>The complexation of hydroxypropyl--cyclodextrin with bicyclic compounds was studied. 5,8-Dihydroxy-1,4-naphthoquinone derivatives(6+6 ring structure) and indole derivatives (6+5 ring structure) were used as the model chemicals and the solubility increment was employed as an indicator to monitor the complexation progress. The solubility experiments revealed that the position and 3-dimensional structure of the substituents provided more impact on the solubility

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Mokhtar, Mohd Noriznan. "Biocatalytic Production, Preparation and Characterization of Large-ring Cyclodextrins." Doctoral thesis, 2008. https://monarch.qucosa.de/id/qucosa%3A19091.

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Cyclodextrins (CD) are cyclic oligosaccharides composed of six to more than sixty glucose units. Large-ring cyclodextrins (LR-CD) are novel CD comprised of more than eight glucose units with cavity structures and sizes different from that of commercially available CD<sub>6</sub> – CD<sub>8</sub>. LR-CD may offer unique molecular recognition properties and can be produced biocatalytically from starch using cyclodextrin glucanotransferase (CGTase, E.C. 2.4.1.19) in a short reaction time. LR-CD were isolated from glucose, CD<sub>6</sub> – CD<sub>8</sub> and other compounds by complexation of CD<s

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Svobodová, Jana. "Enantioselektivní separační systémy v kapilární elektroforéze." Doctoral thesis, 2012. http://www.nusl.cz/ntk/nusl-305918.

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Chiral separation systems in capillary electrophoresis are in the scope of interest of many research groups all over the world. Therefore, the need to develop reliable theoretical models, which would help to explain phenomena connected with chiral separations or optimization of separation conditions, is obvious. In this thesis several mathematical models and approaches that can fulfill these requirements are presented. First part of the thesis deals with the determination of rate constants of interconversion of enantiomers by means of dynamic capillary electrophoresis. We focused on mixtures o

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Lee, Guan Wei, and 李冠瑋. "Optimization of complexation processes for quercetin and curcumin with cyclodextrins and their topical drug delivery." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/q3jm3a.

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Provazníková, Adéla. "Syntéza sulfanylaminoderivátů cyklodextrinů a počítačová simulace tvorby jejich komplexů." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-344070.

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This master thesis deals with synthesis of 6I -N-monosubstituted β-CD bearing a linear spacer of various lenghts containing disulfidic bond and terminated by amine. Whole series was succesfully prepared by nucleophilic substitution of toluenesulfonyl group on tosyl β-CD by a spacer's amine group. In case of the shortest spacer (cystamine) 35 % yield was achieved. Synthesis of β-CD derivatives using longer and more lipophilic spacer derived from di-, tri- and tetraethylenglycol yielded 66 to 85 %. The oligoethylene spacers were prepared by standard chemical modifications. A separation method us

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Al-Rimawi, Fuad [Verfasser]. "New mixed-mode methacrylate-based polymeric monoliths prepared via complexation with cyclodextrins employed as stationary phases for capillary electrochromatography / vorgelegt von Fuad Al-Rimawi." 2007. http://d-nb.info/98532743X/34.

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Magro, Maria Inês Martins. "Development of mucoadhesive patches for buccal drug delivery." Master's thesis, 2014. http://hdl.handle.net/10451/39273.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Clonazepam is a benzodiazepine used for the treatment of epilepsy and panic disorders. Its poor water solubility compromises its bioavailability, making it necessary to develop strategies that bypass this problem. A very promising one is the complexation with cyclodextrins, which has been widely used in the pharmaceutical field. Antiepileptic drug are usually given orally, but to avoid certain drawbacks like the first pass metabolism, other routes are being considered, such as t

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