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Journal articles on the topic 'Cyclodextrin Complexation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Durand, Amaury, David Mathiron, Sébastien Rigaud, Florence Djedaini-Pilard та Frédéric Marçon. "Rapid Study on Mefloquine Hydrochloride Complexation with Hydroxypropyl-β-Cyclodextrin and Randomly Methylated β-Cyclodextrin: Phase Diagrams, Nuclear Magnetic Resonance Analysis, and Stability Assessment". Pharmaceutics 15, № 12 (2023): 2794. http://dx.doi.org/10.3390/pharmaceutics15122794.

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This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution. This approach may enhance the effectiveness of mefloquine, a drug which can be used for malaria prophylaxis and treatment in children. Mefloquine hydrochloride’s solubility was assessed in different buffer solutions, and its quantification was achieved through high-performance liquid chromatography. The complexation efficiency with cyclodextrins was evaluated, and nuclear magnetic resonance (NMR) methods were employed to determine the interactions

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2

Kopecký, František, Mária Vojteková, Silvia Kováčová та Monika Juríčeková. "Inclusion Complexation of Carbethopendecinium Bromide with Some α- and β-Cyclodextrins Studied by Potentiometry with Membrane Electrodes". Collection of Czechoslovak Chemical Communications 69, № 2 (2004): 384–96. http://dx.doi.org/10.1135/cccc20040384.

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Inclusion complexation of an antimicrobial quaternary ammonium salt, carbethopendecinium bromide (SBr, Septonex), with five cyclodextrins was investigated potentiometrically using the prepared membrane electrodes selective to the surface-active carbethopendecinium cations (S+). Relatively strong complexation of the S+ cations with native α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), and their random-substituted derivatives, namely hydroxypropyl-α-cyclodextrin (HP-α-CD), methyl-β-cyclodextrin (M-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD), was evidenced in dilute aqueous solution. In the

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3

Aher, Sayee V., and Yogesh V. Pore. "Physicochemical Characterization of Febuxostat Microcomplexes with Parent and Modified Cyclodextrins." Dhaka University Journal of Pharmaceutical Sciences 17, no. 1 (2018): 51–63. http://dx.doi.org/10.3329/dujps.v17i1.37119.

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Febuxostat, a BCS class II antigout drug was complexed with β-cyclodextrin (βCD), hydroxypropyl-β- cyclodextrin (HPβCD) and / or methyl-β-cyclodextrin (MβCD), to improve its physicochemical properties. Earlier phase solubility and thermodynamic investigations in acetate buffer (pH 4.5) illustrated AL (linear) type of solubility curve and enthalpy driven complexation process, respectively. The association constant and complexation efficiency of modified cyclodextrins (CDs) were significantly higher than that of parent cyclodextrin (CD). The microcomplexes prepared by spray drying process were e

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4

Dehabadi, Vahid Ameri, Hans-Jürgen Buschmann та Jochen Stefan Gutmann. "Spectrophotometric estimation of the accessible inclusion sites of β-cyclodextrin fixed on cotton fabrics using phenolic dyestuffs". Anal. Methods 6, № 10 (2014): 3382–87. http://dx.doi.org/10.1039/c4ay00293h.

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With the known stoichiometry of the complex formation of phenolic dyes with β-cyclodextrin, spectrophotometric study of complexation and decomplexation of these dyestuffs in cavities of cyclodextrins enables us to determine the accessible cyclodextrin sites quantitatively.

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5

Kopecký, František, Mária Vojteková, Miloš Vrana та Katarína Čížová. "Potentiometric Study of Carbisocaine Micellization and Inclusion Complexation with α-Cyclodextrin, β-Cyclodextrin, Methyl-β-cyclodextrin, and (Hydroxypropyl)-β-cyclodextrin". Collection of Czechoslovak Chemical Communications 67, № 2 (2002): 245–56. http://dx.doi.org/10.1135/cccc20020245.

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Micellization of the local anesthetic drug carbisocaine hydrochloride (BHCl) was studied by potentiometry with both cation- and anion-selective membrane electrodes in aqueous solution at 25 °C. The found critical micelle concentration 0.022 mol dm-3 and the concentration course of the free carbisocaine cation and chloride counterion in the micellar solution corresponded to the characteristic of cationic surfactants. In a more dilute aqueous solution, below critical micelle concentration, the complexation of carbisocaine cation BH+ with α-cyclodextrin (α-CD), β-cyclodextrin (β-CD) and its rando

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6

Wang, Runmiao, Hui Zhou, Shirley W. I. Siu, Yong Gan, Yitao Wang, and Defang Ouyang. "Comparison of Three Molecular Simulation Approaches for Cyclodextrin-Ibuprofen Complexation." Journal of Nanomaterials 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/193049.

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Cyclodextrins are widely used for the solubilisation of poorly soluble drugs in the formulations. However, current cyclodextrin formulation development strongly depends on trial-and-error in the laboratory, which is time-consuming and high cost. The aim of this research was to compare three modeling approaches (Docking, molecular dynamics (MD), and quantum mechanics (QM)) for cyclodextrin/drug complexation. Ibuprofen was used as a model drug. Binding free energy from three simulation methods was calculated as an important parameter to compare with the experimental results. Docking results from

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7

Husain, Noni, Thilivhali T. Ndou, Arsenio Muñoz De La Peña та Isiah M. Warner. "Complexation of Doxorubicin with β and γ-Cyclodextrins". Applied Spectroscopy 46, № 4 (1992): 652–58. http://dx.doi.org/10.1366/0003702924124943.

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The binding of β and γ-cyclodextrins with the anti-cancer drug doxorubicin has been examined with the use of fluorescence and absorbance spectroscopy, circular dichroism measurements, and proton NMR spectroscopy. The stoichiometry of the complexes formed and their apparent formation constants have been estimated with the use of various approaches. The stoichiometrics for both the β-cyclodextrin-doxorubicin complex and the γ-cyclodextrin-doxorubicin complex have been determined to be predominantly 1:1. The strength of the interaction of the drug with γ-cyclodextrin is stronger than that with β-

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8

Jessen, Cecilie Høgfeldt, Jesper Bendix, Theis Brock Nannestad, et al. "CO₂ complexation with cyclodextrins." Beilstein Journal of Organic Chemistry 19 (July 17, 2023): 1021–27. http://dx.doi.org/10.3762/bjoc.19.78.

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Carbon dioxide (CO2) emissions from industrial processes, power generation, and transportation contribute significantly to global warming and climate change. Carbon capture and storage (CCS) technologies are essential to reduce these emissions and mitigate the effects of climate change. Cyclodextrins (CDs), cyclic oligosaccharides, are studied as potential CO2 capture agents due to their unique molecular structures and high selectivity towards CO2. In this paper we have investigated binding efficiency of a number of cyclodextrins towards CO2. It is found that the crystal structure of α-cyclode

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9

Nandi, Saurav, Subal Debnath, Manjunath S Y, Malla Reddy V, Nilesh P. Babre, and M. Gopal Rao. "Improvement of Dissolution Characteristics of Meloxicam by Complexation with Cyclodextrins." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 4 (2011): 1263–70. http://dx.doi.org/10.37285/ijpsn.2010.3.4.11.

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The aim of the present study was an attempt to prepare tablets containing inclusion complexes of meloxicam with β-cyclodextrins and hydroxypropyl-β-cyclodextrin to improve the aqueous solubility of the drug, thus enhances its dissolution rate to show a faster onset of action. Complexation with cyclodextrins has been used as novel approach for designing drug delivery system because of ability for the non-covalent inclusion complexes formation and it has the ability to molecular encapsulate meloxicam into their hydrophobic cavity without the formation of any covalent bonds. Meloxicam complexatio

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10

Székely-Szentmiklósi, Blanka, and B. Tőkés. "Study of Cyclodextrin/Fluoroquinolone Inclusion Complexes by Capillary Electrophoresis." Acta Medica Marisiensis 59, no. 2 (2013): 107–10. http://dx.doi.org/10.2478/amma-2013-0026.

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AbstractIntroduction: In the present work we evaluated the complexation role of cyclodextrins toward fluoroquinolones in an attempt to assess their potential as new formulation additives for more efficient fluoroquinolone delivery and as selectors in capillary electrophoresis.Material and method: Guest-host interactions of two second generation quinolones, ciprofloxacin and norfloxacin with four cyclodextrins, beta-cyclodextrin (β-CD), gamma-cyclodextrin (γ-CD) and two beta-cyclodextrin derivatives, 2-hydroxypropyl beta-cyclodextrin (HP-β-CD) and randomly methylated beta-cyclodextrin (RAMEB),

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11

Reetz, Manfred T., Joachim Rudolph та Richard Goddard. "Diastereotopic group recognition in the solid state A unique intramolecular β-cyclodextrin inclusion complex". Canadian Journal of Chemistry 79, № 11 (2001): 1806–11. http://dx.doi.org/10.1139/v01-148.

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The phenomenon of diastereotopic group recognition has been structurally documented for the first time. A diphenylphosphine-modified β-cyclodextrin having two diastereotopic phenyl groups in close vicinity to the inner cavity of this host was prepared. The crystal structure analysis reveals selective intramolecular complexation of one of the two diastereotopic phenyl groups.Key words: supramolecular chemistry, stereotopic group recognition, cyclodextrins, intramolecular complexation.

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12

Ceborska, Magdalena, Aleksandra Siklitskaya, Aneta Aniela Kowalska та Karolina Kędra. "Synergetic Effect of β-Cyclodextrin and Its Simple Carbohydrate Substituents on Complexation of Folic Acid and Its Structural Analog Methotrexate". Pharmaceutics 16, № 9 (2024): 1161. http://dx.doi.org/10.3390/pharmaceutics16091161.

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Folic acid (FA) and its structural analog, anticancer medicine methotrexate (MTX), are known to form host/guest complexes with native cyclodextrins, of which the most stable are formed with the medium-sized β-cyclodextrin. Based on our research, proving that simple sugars (D-glucose, D-galactose, and D-mannose) can form adducts with folic acid, we envisioned that combining these two types of molecular receptors (cyclodextrin and simple carbohydrates) into one may be beneficial for the complexation of FA and MTX. We designed and obtained host/guest inclusion complexes of FA and MTX with two mon

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13

Shehatta, Ibrahim, Ali Hassan Al-Marzouqi, Baboucarr Jobe, and Ali Dowaidar. "Enhancement of aqueous solubility of itraconazole by complexation with cyclodextrins using supercritical carbon dioxide." Canadian Journal of Chemistry 83, no. 10 (2005): 1833–38. http://dx.doi.org/10.1139/v05-181.

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The formation of inclusion complexes between itraconazole, a highly hydrophobic drug, and α-, β-, γ-, and hydroxylpropyl-β-cyclodextrin (HP-β-CD) were assessed using phase-solubility techniques. The solubility of itraconazole increased as a function of cyclodextrin concentration showing an AL phase diagram indicating the formation of soluble complexes with 1:1 stoichiometry. The Gibbs free energies of transfer of the drug from aqueous solution to the cavity of cyclodextrin are negative and increase in magnitude with increasing cyclodextrin concentration. The solubility of itraconazole, as well

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14

Kinart, Zdzisław. "Stability of the Inclusion Complexes of Dodecanoic Acid with α-Cyclodextrin, β-Cyclodextrin and 2-HP-β-Cyclodextrin". Molecules 28, № 7 (2023): 3113. http://dx.doi.org/10.3390/molecules28073113.

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In the presented work, the stability of the formation of inclusion complexes of dodecanoic acid (lauric acid) with three cyclodextrins, α-cyclodextrin, β-cyclodextrin and 2-HP-β-cyclodextrin, was analyzed from the point of view of the size of the cavity in cyclodextrins, their molar mass and the structure of the studied fatty acid. The measurements were made in a wide temperature range of 283.15–318.15K. The conductometric method was used for these studies. The results obtained allowed us to determine the value of the theoretical limiting molar conductivity (Λm0) of the studied complexes, the

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15

Vieira, Thiago, Adílis K. Alexandria, Lilian H. Amaral, et al. "Cyclodextrin and TiF4 Nanocomplex on Enamel Demineralization." Brazilian Dental Journal 31, no. 4 (2020): 423–30. http://dx.doi.org/10.1590/0103-6440202002531.

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Abstract The aim of this study was to assess the effect of a newly developed nanocomplex formed of hydroxypropyl-b-cyclodextrin and 1% titanium tetrafluoride (TiF4) after distinct complexation periods (12/72 h) on demineralization of bovine enamel in vitro. Enamel blocks (n=60) were allocated in different groups: Mili-Q water, hydroxypropyl-b-cyclodextrin, 1% TiF4, hydroxypropyl-b-cyclodextrin + 1% TiF4 after 12 h of complexation and hydroxypropyl-b-cyclodextrin + 1% TiF4 after 72 h of complexation. The samples were evaluated by surface microhardness, cross-sectional microhardness and micro-CT

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16

Patel, V. P., M. C. Gohel, and R K Parikh. "In Vitro Dissolution Enhancement of Felodipine." Indo Global Journal of Pharmaceutical Sciences 01, no. 02 (2011): 194–205. http://dx.doi.org/10.35652/igjps.2011.19.

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Purpose: With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug candidates are based on activity alone. Other physiochemical and biopharmaceutical properties such as permeability, biopharmaceutics and metabolism are rarely considered during the selection process. The aim of this study was to increase dissolu

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17

Gidwani, Bina, and Amber Vyas. "A Comprehensive Review on Cyclodextrin-Based Carriers for Delivery of Chemotherapeutic Cytotoxic Anticancer Drugs." BioMed Research International 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/198268.

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Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are associated with poor physicochemical and biopharmaceutical properties, which makes the formulation difficult. An important approach in this regard is the use of combination of cyclodextrin and nanotechnology in delivery system. This paper provides an overview of limitations associated with anticancer drugs, their complexation with cyclodextrins, loading/encapsulating the complexed drugs into carriers, and various approaches used for the delivery. The present review article aims to assess the utility

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18

Solomon, Cristina, Valentina Anuța, Iulian Sarbu, et al. "Enhancing the Drug Release and Physicochemical Properties of Rivaroxaban via Cyclodextrin Complexation: A Comprehensive Analytical Approach." Pharmaceuticals 18, no. 6 (2025): 761. https://doi.org/10.3390/ph18060761.

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Background/Objectives: Rivaroxaban, an oral anticoagulant, shows poor aqueous solubility, posing significant challenges to its bioavailability and therapeutic efficiency. The present study investigates the improvement of rivaroxaban’s solubility through the formation of different inclusion complexes with three cyclodextrin derivatives, such as β-cyclodextrin (β-CD), methyl-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD) prepared by lyophilization in order to stabilize the complexes and improve dissolution characteristics of rivaroxaban. Methods: The physicochemical propert

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19

Hoelm, Marta, Nilkanta Chowdhury, Sima Biswas, Angshuman Bagchi, and Magdalena Małecka. "Theoretical Investigations on Free Energy of Binding Cilostazol with Different Cyclodextrins as Complex for Selective PDE3 Inhibition." Molecules 29, no. 16 (2024): 3824. http://dx.doi.org/10.3390/molecules29163824.

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Cilostazol is a phosphodiesterase III inhibitor characterized by poor solubility. This limitation can be overcome by using a drug carrier capable of delivering the drug to the target site. Cyclodextrins are essential as drug carriers because of their outstanding complexation abilities and their capacity to improve drug bioavailability. This study comprises two stages: The first involves verifying different cyclodextrins and their complexation abilities towards cilostazol. This was accomplished using molecular docking simulations (MDS) and density functional theory (DFT). Both techniques indica

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20

Wang, Jie, Zhiqiang Qiu, Yiming Wang, et al. "Supramolecular polymer assembly in aqueous solution arising from cyclodextrin host–guest complexation." Beilstein Journal of Organic Chemistry 12 (January 12, 2016): 50–72. http://dx.doi.org/10.3762/bjoc.12.7.

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The employment of cyclodextrin host–guest complexation to construct supramolecular assemblies with an emphasis on polymer networks is reviewed. The main driving force for this supramolecular assembly is host–guest complexation between cyclodextrin hosts and guest groups either of which may be discrete molecular species or substituents on a polymer backbone. The effects of such complexation on properties at the molecular and macroscopic levels are discussed. It is shown that cyclodextrin complexation may be used to design functional polymer materials with tailorable properties, especially for p

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21

Okano, L. T., R. Ovans, V. Zunic, J. N. Moorthy та C. Bohne. "Effect of cyclodextrin complexation on the photochemistry of the lignin model α-guaiacoxyacetoveratrone". Canadian Journal of Chemistry 77, № 8 (1999): 1356–65. http://dx.doi.org/10.1139/v99-137.

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The photodecomposition of α-guaiacoxyacetoveratrone (GAV) in homogeneous solvents and in aqueous cyclodextrin solutions was studied by following the fluorescence emission of the photoproducts formed. The same qualitative behavior as previously observed for the photodegradation quantum yield measurements was reproduced in the fluorescence studies in dry or wet methanol and acetonitrile. The yield for GAV photodegradation in water is smaller than in the organic solvents. Complexation of GAV to β- and γ-cyclodextrins leads to an increase in the photodecomposition yield, especially during the earl

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22

Sharma, A., K. Anderson, and J. W. Baker. "Flocculation of serum lipoproteins with cyclodextrins: application to assay of hyperlipidemic serum." Clinical Chemistry 36, no. 3 (1990): 529–32. http://dx.doi.org/10.1093/clinchem/36.3.529.

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Abstract We describe the complexation of isolated and native lipoproteins by natural macrocyclic polymers of glucose ("cyclodextrins"). Treatment of serum with cyclodextrin produces an immediate flocculation of the lipoproteins. The formation of cyclodextrin-lipoprotein complexes was evident on agarose electrophoresis gels. The concentration-dependent ability of alpha-cyclodextrin to precipitate chylomicrons and very-low-, low-, and high-density lipoproteins was used for clarifying lipemic serum. Results for normal and lipemic patients' specimens for some routinely measured analytes showed a g

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23

Bashir, Mehreen, Haroon Khalid Syed, Sajid Asghar, et al. "Effect of Hydrophilic Polymers on Complexation Efficiency of Cyclodextrins in Enhancing Solubility and Release of Diflunisal." Polymers 12, no. 7 (2020): 1564. http://dx.doi.org/10.3390/polym12071564.

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The effects of three hydrophilic polymers, namely, carboxymethyl cellulose sodium (CMC-Na), polyvinyl alcohol (PVA) and poloxamer-188 (PXM-188) on the solubility and dissolution of diflunisal (DIF) in complexation with β-cyclodextrin (βCD) or hydroxypropyl β-cyclodextrin (HPβCD), were investigated. The kneading method was used at different drug to cyclodextrin weight ratios. Increases in solubility and drug release were observed with the DIF/βCD and DIF/HPβCD complexes. The addition of hydrophilic polymers at 2.5, 5.0 and 10.0% w/w markedly improved the complexation and solubilizing efficiency

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24

Xu, Chongsheng, Nan He, Zhenhua Li, Yanqiu Chu, and Chuan-Fan Ding. "Exploring halide anion affinities to native cyclodextrins by mass spectrometry and molecular modelling." European Journal of Mass Spectrometry 24, no. 3 (2017): 269–78. http://dx.doi.org/10.1177/1469066717748658.

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The binding affinities of cyclodextrins complexation with chlorine (Cl−), bromine (Br−) and iodine (I−), were measured by mass spectrometric titrimetry, and the fitting of the binding constants was based on the concentration measurement of the cyclodextrin equilibrium. The binding constants (lg Ka) for α-, β- or γ-cyclodextrin with Cl− were 3.99, 4.03 and 4.11, respectively. The gas-phase binding affinity of halide anions for native cyclodextrins was probed by collision-induced dissociation. In collision-induced dissociation, the centre-of-mass frame energy results revealed that in the gas pha

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25

Jagtap, Sneha, та Magdum Chandrakant. "Enhanced dissolution and solubility of Epalrestat with β-Cyclodextrin ternary complex using Arginine". Journal of Drug Delivery and Therapeutics 8, № 6 (2018): 62–67. http://dx.doi.org/10.22270/jddt.v8i6.2014.

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The objective of present is work to achieve improvement in solubility and dissolution using Epalrestat with β-cyclodextrin ternary complex with addition of L-arginine. Kneading method with and without incorporation of L-arginine was used to obtain the solid systems (binary and ternary complex) of Epalrestat with β-cyclodextrin and characterized for DSC, PXRD, SEM. Phase solubility, saturation solubility, dissolution and stability studies were carried out. The effect of L-arginine was investigated on complexation efficiency of β-cyclodextrin towards Epalrestat in an aqueous media through phase

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26

Delyagina, E. S., A. A. Garibyan та I. V. Terekhova. "Comparative Analysis of the Effect of Native and Polymeric β-Cyclodextrins on the Solubility and Membrane Permeability of Baricitinib". Журнал физической химии 97, № 8 (2023): 1218–24. http://dx.doi.org/10.31857/s0044453723080046.

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A study is performed of the effect native and polymeric β-cyclodextrins have on the solubility and membrane permeability of baricitinib, a new generation immunomodulator. It is found that native and polymeric β-cyclodextrins exhibit the same solubilizing effect in relation to baricitinib, while their effect on the membrane permeability of the drug differs. The increased solubility of baricitinib is due to the formation of inclusion complexes that have the same stability but are enthalpy-entropy stabilized in native β-cyclodextrin and enthalpy stabilized in polymeric β-cyclodextrin. The effect

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27

Tóth, Gergő, Ádám Jánoska, Gergely Völgyi, et al. "Physicochemical Characterization and Cyclodextrin Complexation of the Anticancer Drug Lapatinib." Journal of Chemistry 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/4537632.

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Lapatinib (LAP), the tyrosine kinase inhibitor drug with moderate bioavailability, was characterized in terms of physicochemical properties: acid-base characteristics, lipophilicity, and solubility. The highly lipophilic nature of the drug and its extremely low water solubility (S0=0.82 nM) limit the development of a parenteral formulation. In order to enhance solubility and bioavailability, inclusion complex formation with cyclodextrins (CDs) is a promising method of choice. Therefore, LAP-CD interactions were also studied by a multianalytical approach. The stability constants of LAP with nat

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Londhe, Vaishali Yogesh, та Sreevidya Ramesh Krishnan. "Effect of inclusion of citric acid and Lutrol® F-68 on ziprasidone and β-cyclodextrin complexation: Characterization, solubility and dissolution studies". European Journal of Chemistry 11, № 4 (2020): 280–84. http://dx.doi.org/10.5155/eurjchem.11.4.280-284.2010.

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Ziprasidone (ZPR) is an antipsychotic agent having less solubility. It is used for the treatment of schizophrenia. Complexation of hydrophobic drugs with cyclodextrins leads to enhanced solubility and dissolution. In this study, inclusion complexes were prepared by different methods, using ZPR, β-cyclodextrin (β-CD), and different auxiliary agents like hydrophilic polymer and hydroxy acid (1:1:0.5) to improve the aqueous solubility. The characterization of the ternary complexes was carried out using solubility study, Differential scanning calorimetry (DSC), Powder X-ray diffraction (PXRD), Fou

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Mikaelian, Georgios, Grigorios Megariotis, and Doros N. Theodorou. "Molecular simulations of doxorubicin complexed with native and modified cyclodextrins in water." Journal of Physics: Conference Series 2701, no. 1 (2024): 012007. http://dx.doi.org/10.1088/1742-6596/2701/1/012007.

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Abstract In this study, all-atom molecular dynamics simulations have been performed to investigate from a nanoscopic point of view the interactions in supramolecular complexes formed between doxorubicin and cyclodextrins in an aqueous phase at a temperature of 310 K. All the simulations are on the time scales of microseconds and are carried out on High Performance Computing resources provided by the Greek Supercomputer ARIS. Doxorubicin, which is a well-known anticancer drug belonging to the class of anthracyclines, is simulated with two cyclodextrins of broad utilization in drug delivery, i.e

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Dodziuk, Helena, Anna Bielejewska, Wojciech Schilf та Haruhisa Ueda. "Complexation of [2.2]paracyclophane with β- and γ-cyclodextrins studied by HPLC and NMR". Open Chemistry 9, № 6 (2011): 1056–61. http://dx.doi.org/10.2478/s11532-011-0095-6.

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AbstractThe NMR spectra of [2.2]paracyclophane with β- or γ-cyclodextrin in DMF-d7 at room temperature do not show significant complexation, while HPLC of the complexes in mixed H2O:alcohol solvents demonstrate complexation with different stoichiometries. At 243 K in DMF solution the H3 and H5 NMR signals of γ-cyclodextrin (but not β) exhibit complexation-induced chemical shifts denoting complex formation. According to HPLC, at room temperature the [2.2]paracyclophane complex with β-cyclodextrin in 20% H2O:EtOH exhibits 1:2 stoichiometry with K 1 = 1×102 ± 2, K 2 = 9.0×104 ± 2×103 (K = 9×106)

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Ngo, Huy T., Philip Clements, Christopher J. Easton, Duc-Truc Pham та Stephen F. Lincoln. "Supramolecular Chemistry of Pyronines B and Y, β-Cyclodextrin and Linked β-Cyclodextrin Dimers". Australian Journal of Chemistry 63, № 4 (2010): 687. http://dx.doi.org/10.1071/ch09467.

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The complexation of cationic pyronine B (PB+) and pyronine Y (PY+) by β-cyclodextrin (βCD) and two linked βCD dimers, N,N′-bis((2AS,3AS)-3A-deoxy-β-cyclodextrin-3A-yl)succinamide, 33βCD2suc, and N,N′-bis(6A-deoxy-β-cyclodextrin-6A-yl)succinamide, 66βCD2suc, in aqueous solution has been studied by UV-vis, fluorescence, and 1H NMR spectroscopy. The complexation constants for the 1:1 complexes: βCD.PB+, 33βCD2suc.PB+, 66βCD2suc.PB+, and the analogous PY+ complexes are reported as are the dimerization constants for PB+ and PY+. The modes of complexation, dimerization, and fluorescence quenching ar

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32

González-Ruiz, Víctor, Ángel Cores, Olmo Martín-Cámara, et al. "Enhanced Stability and Bioactivity of Natural Anticancer Topoisomerase I Inhibitors through Cyclodextrin Complexation." Pharmaceutics 13, no. 10 (2021): 1609. http://dx.doi.org/10.3390/pharmaceutics13101609.

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The use of cyclodextrins as drug nano-carrier systems for drug delivery is gaining importance in the pharmaceutical industry due to the interesting pharmacokinetic properties of the resulting inclusion complexes. In the present work, complexes of the anti-cancer alkaloids camptothecin and luotonin A have been prepared with β-cyclodextrin and hydroxypropyl-β-cyclodextrin. These cyclodextrin complexes were characterized by nuclear magnetic resonance spectroscopy (NMR). The variations in the 1H-NMR and 13C-NMR chemical shifts allowed to establish the inclusion modes of the compounds into the cycl

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Fenyvesi, Ferenc, Thi Le Phuong Nguyen, Ádám Haimhoffer, et al. "Cyclodextrin Complexation Improves the Solubility and Caco-2 Permeability of Chrysin." Materials 13, no. 16 (2020): 3618. http://dx.doi.org/10.3390/ma13163618.

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Chrysin is a bioflavonoid that can be found in natural products such as honey and propolis, and it possesses several biological effects such as antioxidant, anti-inflammatory, and anti-cancer activity. However, it is poorly soluble in water, and its bioavailability is limited. The aim of this research is to investigate the chrysin solubilization capacity of different β-cylcodextrin derivatives and compare their biological activities. Chrysin was complexed with β-cyclodextrin (βCD), hydroxypropyl-β-, (HPBCD) sulfobutylether-β-, (SBECD), and randomly-methylated-β-cyclodextrin (RAMEB) by the lyop

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Agafonov, M. A., та I. V. Terekhova. "Features of complex formation of native and polymeric β-cyclodextrins with sulfasalazine". Журнал общей химии 93, № 5 (2023): 785–93. http://dx.doi.org/10.31857/s0044460x2305013x.

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The work is devoted to the study of the complex formation of sulfasalazine with native and polymeric β-cyclodextrins in buffer solutions with a physiological pH value using isothermal saturation and 1H NMR methods. It was established that sulfasalazine forms two types of complexes when interacting with the cyclodextrins under consideration, but only the process of formation of inclusion complexes determines the observed increase in drug solubility, which is more pronounced in the presence of polymeric β-cyclodextrin. It was determined that complexation with β-cyclodextrin and its polymeric der

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Croft, Anna K., Christopher J. Easton, Stephen F. Lincoln, Bruce L. May, and John Papageorgiou. "An H.P.L.C. Study of Cooperative Guest Binding by a Covalently Linked b-Cyclodextrin Dimer." Australian Journal of Chemistry 50, no. 8 (1997): 857. http://dx.doi.org/10.1071/c97045.

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The complexation of the anions of Methyl Orange (MO¯) (1) and Indomethacin (Ind-) (2) by the β-cyclodextrin dimer (3) has been studied by means of high-performance liquid chromatography. The cyclodextrin annuli are shown to jointly act as a single binding site for complexation of MO¯ (1). Thus the association constants of (3·3±0·3) × 103 and (220±20) × 103 dm3 mol−1 for the 1 : 1 complexes with β-cyclodextrin and the dimer (3), respectively, indicate very strong cooperative binding by the annuli of the linked species. By contrast, the complexation of Ind¯ (2) by the cyclodextrin dimer (3) is c

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Fazylov, S., O. Nurkenov, I. Pustolaikina, et al. "CLATHRATE COMPLEXES OF HYDRAZONES OF 2- AND 4-HYDROXYBENZOIC ACIDS WITH CYCLODEXTRINS AND THEIR PROPERTIES." Chemical Journal of Kazakhstan, no. 1 (March 27, 2025): 25–36. https://doi.org/10.51580/2025-1.2710-1185.03.

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The paper presents the results of a study on the preparation of water-soluble complexes of inclusions of 4- and 2-hydroxyhydrazides of benzoic acid and their hydrazones with cyclodextrins (β-CD, γ-CD) in an aqueous alcohol solution. Methods. The complexation of the obtained hydrazones with --, -, -cyclodextrins was studied in silico using molecular docking and modeling methods. Results and discussion. All the investigated hydrazones demonstrated the best value of binding affinity with β -cyclodextrin. The efficiency of binding of the studied hydrazones to cyclodectrins is provided primarily

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Koester, L. S., S. S. Guterres, M. Le Roch, V. L. Eifler-Lima, J. A. Zuanazzi та V. L. Bassani. "Ofloxacin/β-Cyclodextrin Complexation". Drug Development and Industrial Pharmacy 27, № 6 (2001): 533–40. http://dx.doi.org/10.1081/ddc-100105178.

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Şuta, Lenuţa-Maria, Amalia Ridichie, Adriana Ledeţi, et al. "Host–Guest Complexation of Itraconazole with Cyclodextrins for Bioavailability Enhancement." Pharmaceutics 16, no. 4 (2024): 560. http://dx.doi.org/10.3390/pharmaceutics16040560.

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Itraconazole is an antifungal agent included in the triazole pharmacological classification that belongs to the BCS class II, characterized by a low solubility in an aqueous medium (of 1 ng/mL, at neutral pH), which is frequently translated in a low oral bioavailability but with a high permeability. In this sense, it is necessary to find solutions to increase/improve the solubility of itraconazole in the aqueous environment. The main purpose of this study is the preparation and analysis of five different guest–host inclusion complexes containing intraconazole. Initially, a blind docking proces

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Banchero, Mauro. "Supercritical Carbon Dioxide as a Green Alternative to Achieve Drug Complexation with Cyclodextrins." Pharmaceuticals 14, no. 6 (2021): 562. http://dx.doi.org/10.3390/ph14060562.

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Cyclodextrins are widely used in pharmaceutics to enhance the bioavailability of many drugs. Conventional drug/cyclodextrin complexation techniques suffer from many drawbacks, such as a high residual content of toxic solvents in the formulations, the degradation of heat labile drugs and the difficulty in controlling the size and morphology of the product particles. These can be overcome by supercritical fluid technology thanks to the outstanding properties of supercritical CO2 (scCO2) such as its mild critical point, its tunable solvent power, and the absence of solvent residue after depressur

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Bhadale, Rupali, and Vaishali Londhe. "Inclusion Complex of Iloperidone with Sulfobutyl Ether Beta-Cyclodextrin: Characterization and Dissolution Studies." Proceedings 78, no. 1 (2020): 22. http://dx.doi.org/10.3390/iecp2020-08715.

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Iloperidone (ILO) is a second-generation antipsychotic drug and a first-line treatment approved by USFDA in May 2009. Iloperidone belongs to Biopharmaceutical Classification Systems (BCS) class II; thus, it is poorly water-soluble, highly permeable, and has pH-dependent solubility. Cyclodextrins and their derivatives have a wide range of applications in different formulations due to their complexation ability, which improves the solubility, stability, safety, and bioavailability of a drug. We have tried the complexation of iloperidone with sulfobutyl ether-β-cyclodextrin (SEβCD) to improve its

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Godge, Ganesh Raosaheb, Shivanand Hiremath, Bhakti Sonawale, and Rani Shirsath. "Pharmaceutical Advances in Cyclodextrin Inclusion Complexes for Improved Bioavailability of Poorly-Soluble Drugs." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 3 (2015): 2894–905. http://dx.doi.org/10.37285/ijpsn.2015.8.3.2.

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Cyclodextrins (CDs) are commonly used in drug formulations as solubility enhancers because of their ability to form water-soluble inclusion complexes with poorly water-soluble drugs. Cyclodextrins are useful molecular chelating agents. The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. Orally administered drugs completely absorb only when they show fair solubility in gastric medium and such drugs shows good bioavailability. The solubility and dissolution prope

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Bucur, Pálma, Ibolya Fülöp, and Emese Sipos. "Insulin Complexation with Cyclodextrins—A Molecular Modeling Approach." Molecules 27, no. 2 (2022): 465. http://dx.doi.org/10.3390/molecules27020465.

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Around 5% of the population of the world is affected with the disease called diabetes mellitus. The main medication of the diabetes is the insulin; the active form is the insulin monomer, which is an instable molecule, because the long storage time, or the high temperature, can cause the monomer insulin to adapt an alternative fold, rich in β-sheets, which is pharmaceutically inactive. The aim of this study is to form different insulin complexes with all the cyclodextrin used for pharmaceutical excipients (native cyclodextrin, methyl, hydroxyethyl, hydroxypropyl and sulfobutylether substituted

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Kelemen, Hajnal, Gabriel Hancu, Bernadette Mentes, et al. "Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives." Revista de Chimie 70, no. 8 (2019): 2737–41. http://dx.doi.org/10.37358/rc.19.8.7418.

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The aim of this study is to confirm the formation of inclusion complexes between fluconazoleand different cyclodextrin derivatives. Fluconazole is slightly soluble in water, but its solubility can be further increased by complexation with cyclodextrins. The binary systems between fluconazole and cyclodextrins were prepared in 1:1 molar ratios by physical-mixture method and kneading method. Differential scanning calorimetry (DSC), Fourier transformed-infrared spectroscopy (FT-IR) and molecular modeling methods were used to characterize solid state interactions between fluconazole and cyclodextr

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Zornoza, Arantza, Itziar Vélaz, Gustavo González-Gaitano та María Cristina Martínez-Ohárriz. "A Comprehensive Study of Gemfibrozil Complexation with β-Cyclodextrins in Aqueous Solution Using Different Analytical Techniques". International Journal of Molecular Sciences 23, № 24 (2022): 16119. http://dx.doi.org/10.3390/ijms232416119.

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Gemfibrozil (GEM) is a hypolipidemic agent, which is effective in reducing serum cholesterol and triglyceride levels. Complexation of GEM with native β-cyclodextrin (β-CD) and with the derivatives hydroxypropyl-β- and randomly methylated β-CD (HPβ-CD and Meβ-CD) was studied in aqueous solution of pH 2.8 and 7.0. The stability constants were determined by spectrofluorimetry, 1H-NMR spectroscopy and solubility assays. Considering the well-known difficulties to obtain similar stability constants by different techniques, the agreement of the values obtained supports the reliability of the results

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Avinash, Gupta, Sharma Vijay, Sharma Ashutosh, K. Gupta Manish, and Jaiswal Praveen. "Proportional Assessment of Oral Tablets Having Complex of Cyclodextrin And BCS Class II Drugs." International Journal of Toxicological and Pharmacological Research 11, no. 1 (2021): 9–16. https://doi.org/10.5281/zenodo.12678858.

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Today in Pharma area it turns into an extreme wok to make a formula of active molecules having poor water dissolvability. This explanation, that at present different beneficial active molecules don’t go to the market because of less disintegration and at last less bioavailability. According to the BCS classifications drugs like Elvitegravir which has a place with class II have the less solvency and great penetrability. In this way, it turns into a basic test for a formulator, to figure these medications having the whimsical or non-uniform medication discharge profile, drug retention infl

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Bagal, Priyanka A. and Joshi Hrushikesh A*. "PHASE SOLUBILITY STUDIES OF IBUPROFEN WITH β-CYCLODEXTRIN AND HYDROXY PROPYL- β CYCLODEXTRIN IN DIFFERENT BUFFER MEDIA". Indo American Journal of Pharmaceutical Sciences 04, № 08 (2017): 2386–92. https://doi.org/10.5281/zenodo.845719.

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An oral route of drug administration is the most common and preferred method of delivery due to its convenience and ease of ingestion, but for many of drugs it can be hard way due to poor solubility. As the therapeutic activity of drugs is related to their solubility in water, in case of poorly water-soluble drugs, dissolution is the rate-limiting step in the process of drug absorption hence will lead to low bioavailability. To overcome the problems related with oral absorption and bioavailability issue, several strategies have been utilized including hydrotrpes, complexation, microcapsulation

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Raut, Sushil Y., Alekhya S. N. Manne, Guruprasad Kalthur, Sanyog Jain, and Srinivas Mutalik. "Cyclodextrins as Carriers in Targeted Delivery of Therapeutic Agents: Focused Review on Traditional and Inimitable Applications." Current Pharmaceutical Design 25, no. 4 (2019): 444–54. http://dx.doi.org/10.2174/1381612825666190306163602.

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The objective of the article is to provide a comprehensive review on the application of cyclodextrin complexation in the delivery of drugs, bioactive molecules or macromolecules, with more emphasis on targeted drug delivery. Classically the cyclodextrins have been considered only as a means of improving the solubility of drugs; however, many attempts have been made to use cyclodextrins as drug delivery carriers. The cyclodextrin surface can be modified with various ligands for active targeting of drugs. It can also be passively targeted through various triggering mechanisms like thermal, magne

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Nazli, Adila, Milo Malanga, Tamás Sohajda, and Szabolcs Béni. "Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery." Pharmaceutics 17, no. 1 (2025): 81. https://doi.org/10.3390/pharmaceutics17010081.

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Cyclodextrins can serve as carriers for various payloads, utilizing their capacity to form unique host–guest inclusion complexes within their cavity and their versatile surface functionalization. Recently, cationic cyclodextrins have gained considerable attention, as they can improve drug permeability across negatively charged cell membranes and efficiently condense negatively charged nucleic acid due to electrostatic interactions. This review focuses on state-of-the-art and recent advances in the construction of cationic cyclodextrin-based delivery systems. First, we identified different cati

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Ol’khovich, Marina V., Angelica V. Sharapova та Svetlana V. Blokhina. "EFFECT OF 2-HYDROXYPROPYL- β -CYCLODEXTRIN ON SOLUBILITY OF NOVEL CYTOTOXIC COMPOUNDS". IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 59, № 3 (2018): 26. http://dx.doi.org/10.6060/tcct.20165903.5318.

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Complexation processes in the systems of 2-hydroxylpropyl-β-cyclodextrin − cytotoxic substances within the temperature range of 293 – 315 К were studied by the UV-spectroscopy method. It was proved that complexation leads to the formation of supramolecular inclusion compounds with 1:1 component ratio. Stability constants of the complexes and thermodynamic parameters of the formation of the inclusion compound 2-hydroxylpropyl-β-cyclodextrin – tris(1-pentyl-1Н-indol-3-yl)methanol were calculated. The obtained complex of 2-hydroxylpropyl-β-cyclodextrin – tris(1-pentyl-1Н-indol-3-yl) methylium chl

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Samprasit, W., Theerasak Rojanarata, Prasert Akkaramongkolporn, Tanasait Ngawhirunpat, and Praneet Opanasopit. "The Influence of Cyclodextrin and pH on the Solubility of Ketoprofen." Advanced Materials Research 506 (April 2012): 433–36. http://dx.doi.org/10.4028/www.scientific.net/amr.506.433.

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Cyclodextrin complexation and pH adjustments have been reported as useful tools to increase the solubility of drug. The aim of this study was to investigate the influence of both cyclodextrin and pH on the overall solubility of ketoprofen. β-cyclodextrin (β-CD) and hydroxypropyl β-cyclodextrin (HP-β-CD) were used for the preparation of inclusion complex by shaking method in aqueous solution at pH 2, 5, 7 and 10. It was found that the solubility of ketoprofen significantly increased with increasing pH and cyclodextrin concentration, showing AL type phase solubility diagram. However, the apparen

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