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Journal articles on the topic 'Cyclohexanol derivative'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Sun, Cheng Guo, Bing Cheng Hu, and Quan Zhi Deng. "The Effect of Disulphide Bond in Metallodeuteroporphyrin on Their Catalytic Activity for Aerobic Oxidation of Cyclohexane." Advanced Materials Research 233-235 (May 2011): 427–30. http://dx.doi.org/10.4028/www.scientific.net/amr.233-235.427.

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Two novel types of metallo-deuteroporphyrins bearing the disulphide bond were employed to investigate their catalytic activity in oxidation of cyclohexane with molecular oxygen (air) to cyclohexanol and cyclohexanone without the use of sacriﬁcial co-reductant. The catalytic activity of metallo-deuteroporphyrin disulphide derivatives was obvious difference when different metals were incorporated into the porphyrin. However, the same metal cobalt porphyrin complexes exhibited the different catalytic efficiency due to the effect of substituents. Co(II)deuteroporphyrin disulphide derivative is mor

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2

Rocco, Dalila, Catherine E. Housecroft, and Edwin C. Constable. "Synthesis of Terpyridines: Simple Reactions—What Could Possibly Go Wrong?" Molecules 24, no. 9 (2019): 1799. http://dx.doi.org/10.3390/molecules24091799.

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The preparation of 24-functionalized 12,22:26,32-terpyridines (4′-functionalized 3,2:6′,3″-terpyridines) by the reaction of three 4-alkoxybenzaldehydes with 3-acetylpyridine and ammonia was investigated; under identical reaction conditions, two (R =nC4H9, C2H5) gave the expected products whereas a third (R = nC3H7) gave only a cyclohexanol derivative derived from the condensation of three molecules of 3-acetylpyridine with two of 4-(n-propoxy)benzaldehyde. A comprehensive survey of “unexpected” products from reactions of ArCOCH3 derivatives with aromatic aldehydes is presented. Three different

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3

Kirillova, Marina V., Polyana Tomé de Paiva, Wagner A. Carvalho, Dalmo Mandelli, and Alexander M. Kirillov. "Mixed-ligand aminoalcohol-dicarboxylate copper(II) coordination polymers as catalysts for the oxidative functionalization of cyclic alkanes and alkenes." Pure and Applied Chemistry 89, no. 1 (2017): 61–73. http://dx.doi.org/10.1515/pac-2016-1012.

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AbstractNew copper(II) catalytic systems for the mild oxidative C–H functionalization of cycloalkanes and cycloalkenes were developed, which are based on a series of mixed-ligand aminoalcohol-dicarboxylate coordination polymers, namely [Cu2(μ-dmea)2(μ-nda)(H2O)2]n·2nH2O (1), [Cu2(μ-Hmdea)2(μ-nda)]n·2nH2O (2), and [Cu2(μ-Hbdea)2(μ-nda)]n·2nH2O (3) that bear slightly different dicopper(II) aminoalcoholate cores, as well as on a structurally distinct dicopper(II) [Cu2(H4etda)2(μ-nda)]·nda·4H2O (4) derivative [abbreviations: H2nda, 2,6-naphthalenedicarboxylic acid; Hdmea, N,N′-dimethylethanolamine

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4

Alikulov, R.V.* Alimnazarov B.Kh. Geldiev Yu.A. Suyunov Zh.R. &. Shukurov D.Kh. "STRUCTURES LUTERGININA." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 8, no. 6 (2019): 273–76. https://doi.org/10.5281/zenodo.3256175.

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In this work, we studied the IR, UV, PMR and mass spectra, chemical transformations of lutherginin and its derivatives of homoproporphine alkaloids of time-lapse. According to the given spectral data, this compound is assigned to the homoproporphine base group with a spiro cyclohexanol ring. When establishing the structure of luterginine, its various spectral data and numerous chemical transformations were studied. The most important of them can be considered following with the action of acetic anhydride and acetic acid sodium from the base obtained O, N-diacetyl derivative, indicating the pre

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5

Kitahara, Takeshi, and Kenji Mor. "Preparation of chiral cyclohexanol derivative with high optical purity by yeast reduction." Tetrahedron Letters 26, no. 4 (1985): 451–52. http://dx.doi.org/10.1016/s0040-4039(00)61908-1.

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6

Muth, Eric A., John T. Haskins, John A. Moyer, George E. M. Husbands, Susan T. Nielsen, and Ernest B. Sigg. "Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative." Biochemical Pharmacology 35, no. 24 (1986): 4493–97. http://dx.doi.org/10.1016/0006-2952(86)90769-0.

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7

Deforth, T., M. Kaschke, H. Stock, H. Pritzkow, and W. Siebert. "Synthesis of C2B3 X-Heterocycles (X = C, N, P, O, S) from 1,3,5-Triborapentanes." Zeitschrift für Naturforschung B 52, no. 7 (1997): 823–30. http://dx.doi.org/10.1515/znb-1997-0711.

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Abstract The hydroboration of acetylene with HBCl2 yields the products (Cl2B)2CHMe (1a), (Cl2BCHMe)2BCl (2a), (Cl2BCHMeBCl)2CHMe (3a), and (ClBCHMe)3 (4a). The crystal structure of 4a as well as of the pentaiodo derivative 2b were determined. A mechanism for the formation of the different hydroboration products is proposed. The 1,3,5-triborapentane 2a serves as precursor for the synthesis of derivatives of 1,3,5-triboracyclohexanes, 1,3,5-tribora-2-aza-cyclohexanes, 1,3,5-tribora-2-phospha-cyclo-hexanes, and 1,3,5-tribora-2-thia-cyclohexanes. Their constitutions have been derived from spectros

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8

Chen, Changzhou, Peng Liu, Minghao Zhou, Brajendra K. Sharma, and Jianchun Jiang. "Selective Hydrogenation of Phenol to Cyclohexanol over Ni/CNT in the Absence of External Hydrogen." Energies 13, no. 4 (2020): 846. http://dx.doi.org/10.3390/en13040846.

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Transfer hydrogenation is a novel and efficient method to realize the hydrogenation in different chemical reactions and exploring a simple heterogeneous catalyst with high activity is crucial. Ni/CNT was synthesized through a traditional impregnation method, and the detailed physicochemical properties were performed by means of XRD, TEM, XPS, BET, and ICP analysis. Through the screening of loading amounts, solvents, reaction temperature, and reaction time, 20% Ni/CNT achieves an almost complete conversion of phenol after 60 min at 220 °C in the absence of external hydrogen. Furthermore, the ca

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9

Mohareb, Rafat Milad, Rehab Ali Ibrahim, Amira Mohamed Elmetwally, and Marwa Soliman Gamaan. "Synthesis of Fused Quinoline Derivatives with Antiproliferative Activities and Tyrosine Kinases, Pim-1 Kinase Inhibitions." Acta Chimica Slovenica 69, no. 1 (2022): 13–29. https://doi.org/10.17344/acsi.2021.6733.

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Cyclohexan-1,3-dione (1) reacted with either 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2a) or diethyl 3-amino-2-cyanopent-2-enedioate (2b) to give the 5,6,7,8-tetrahydronaphthalene derivatives 3a and 3b, respectively. The latter compounds underwent further heterocyclization reactions to give the thieno[2’,3’:5,6]benzo[1,2-e][1,3]oxazine derivatives. On the other hand, the reaction of compound 1 with trichloroacetonitrile afforded the (2,2,2-trichloroethylidene)cyclohexane derivative 14. The latter underwent a series of reactions to produce 2,3,6,7-tetrahydroquinazoline, dihydrothieno[2,3-h]isoq

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10

Bhattacharjee, Rita, and Virupaiah Gayathri. "Synthesis and Characterization of Ru(III) Complexes Containing Quinazoline Derivatives and their Biological and Catalytic Activities." Asian Journal of Chemistry 35, no. 7 (2023): 1645–50. http://dx.doi.org/10.14233/ajchem.2023.27941.

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Ruthenium trichloride trihydrate (RuCl3·3H2O) reacted with quinazoline derivative ligands (L) in 1:1 mole ratio in acetone to yield a series of brown/green/greenish black ruthenium(III) complexes of the type RuX3L·nH2O where X = Cl, n = 0, 1, 2 and 3 and L is 6-R-5,6-dihydrobenzoimidazo[1,2- c]quinazoline (R = ethyl: L1/n or i-propyl: L2, L3/n or i-butyl: L4, L5/phenyl: L6/furyl: L7/thiophenyl: L8/o or p-hydroxyphenyl: L9, L10/o or p-chlorophenyl: L11, L12/dimethylaminophenyl: L13). All the synthesized Ru(III) complexes were characterized by elemental analyses, conductivity measurements, infra

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11

Fraser, Robert R., Corinne Bensimon, Fanzuo Kong, and Xinfu Wu. "An X-ray and conformational study of 5,7-dihydro-1,11-dimethyl-6H-dibenzo[a,c]cyclohepten-6-one and its methyl derivatives." Canadian Journal of Chemistry 71, no. 5 (1993): 685–94. http://dx.doi.org/10.1139/v93-093.

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The crystal structures for the title compound 1 and its α-methyl derivatives 2–4 have been determined. Molecular mechanics calculations of the conformation of minimum energy for 1, 3, and 4 correspond closely to the symmetric structures observed in the crystal. For 2, rotation at the CO—CH2 bond by 24° produced an asymmetric conformation matching that seen in the solid state. The calculated changes in energy as a function of the torsional angle for 1 and 2 were compared with those for cyclohexanone and the axial conformer of the α-methyl derivative. The energy requirements for conformational c

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12

Jiang, Yue, Shuai Wang, Weifu Dong, Tatsuo Kaneko, Mingqing Chen, and Dongjian Shi. "High-Strength, Degradable and Recyclable Epoxy Resin Based on Imine Bonds for Its Carbon-Fiber-Reinforced Composites." Materials 16, no. 4 (2023): 1604. http://dx.doi.org/10.3390/ma16041604.

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Carbon fiber (CF) is widely used in the preparation of carbon-fiber-reinforced polymer composites (CFRP) in which it is combined with epoxy resin due to its good mechanical properties. Thermosetting bisphenol A epoxy resin, as one of the most common polymer materials, is a non-renewable resource, leading to a heavy environmental burden and resource waste. To solve the above problems and achieve high mechanical and thermal properties comparable to those of bisphenol A, herein, a high-performance, degradable and recyclable bio-based epoxy resin was developed by reacting the lignin derivative van

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13

Columbus, Ishay, Manal Haj-Zaroubi, and Silvio E. Biali. "Fully Hydrogenated Calixarene Derivatives: Calix[4]cyclohexanone and Calix[4]cyclohexanol." Journal of the American Chemical Society 120, no. 45 (1998): 11806–7. http://dx.doi.org/10.1021/ja982374m.

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14

Hammouda, M., A. S. El-Ahl, Y. M. El-Toukhee, and M. A. Metwally. "Reactions of Ketonic Mannich Bases with Malononitrile and Malononitrile dimer." Journal of Chemical Research 2002, no. 2 (2002): 89–94. http://dx.doi.org/10.3184/030823402103171258.

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The reaction of malononitrile with the tertiary Mannich base hydrochloride derived from acetophenone and some related compounds 1, 3, 5 and 7, in piperidine at 50°C afforded the pyrido[1,2-a]pyrimidine derivatives 2, tetrahydronaphthalene derivative 4 substituted quinolines 6 and benzopyran derivatives 8. While the condensation of malononitrile dimer with acetophenone, cyclohexanone and/ or α-tetralone Mannich bases hydrochloride 1, 3 and 9 gave the pyridine, isoquinoline and benzo[f]isoquinoline derivatives 10–12 in moderate to good yield.

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15

Flefel, Eman M., Walaa I. El-Sofany, Reem A. K. Al-Harbi, and Mahmoud El-Shahat. "Development of a Novel Series of Anticancer and Antidiabetic: Spirothiazolidines Analogs." Molecules 24, no. 13 (2019): 2511. http://dx.doi.org/10.3390/molecules24132511.

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4-(4-Aminophenyl)-1-thia-4-azaspiro[4.5]decan-3-one 1 was prepared and allowed to react with nitrogen nucleophiles to give the corresponding hydrazones 2–4. Further, compound 1 underwent diazotization and afforded the parallel hydrazono derivative 5; moreover, compound 1 refluxed with active methylene derivatives yielded the corresponding aminospirothiazolo pyridine–carbonitrile derivative 6 and spirothiazolopyridinone–carbonitrile derivative 7. Condensation of spirothiazolidine 1 with 4-chlorobenzaldehyde gave the corresponding spiro arylidiene derivative 8, which was utilized as a component

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16

Nakashima, Katsuyuki, Yuzuru Kondo, Kosei Yoshimasu, Masakazu Sono, and Motoo Tori. "Synthesis of Chiral Hexasubstituted Cyclohexanediol, a Key Intermediate for the Synthesis of Verticillol, from (+)-Dihydrocarvone; Attempted Cyclization to 12-Membered Carbocycle in Verticillol using RCM Reaction." Natural Product Communications 10, no. 4 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000402.

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A cyclohexane derivative with three chiral centers, a key intermediate for the synthesis of a diterpene verticillol, was prepared starting from (+)-dihydrocarvone. A further challenge to cyclize to a 12-membered carbocycle was attempted, although the products were dimeric derivatives presumably due to an undesirable conformation of the substrate.

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17

Afef, Meftah, Messaoudi Nassiba, Khelifa Foudil, Bourhane Djebar Abdallah, and Bachari Khaldoun. "The Attitude In Vitro of 10 Ubiquitous Bacteria in Seawater Polluted by Benzene and Toluene." INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGICAL SCIENCES 5, May & June 2021 (2021): 122–41. https://doi.org/10.5281/zenodo.5150052.

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<em>This study focuses on specifying a number of ubiquitous non-fastidious bacteria isolated from urine hospitalized patients for their abilities to degrade benzene and toluene. Using the MALDI-Tof technique (Bruker Daltonics), these opportunist bacteria have been identified. The bacteria were inoculated and incubated in sterile water contaminated with pure benzene and toluene for 63 days, at room temperature with continuous oxygenation. Analysis by Gas Chromatography/ Mass Spectrometry (GC / MS) HP6890 / HP 5973 MS (Agilent Technologies) allowed us to determine the concentration of each hydro

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18

Sparatore, Fabio, and Anna Sparatore. "3,3-Disubstituted 3,4-Dihydro-1,2,4-benzotriazines: Chemistry, Biological Activity, and Affinity to Sigma Receptors." Molecules 29, no. 1 (2023): 132. http://dx.doi.org/10.3390/molecules29010132.

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By reducing the 2-nitrophenylhydrazone of cyclohexanone with sodium dithionite, an unexpected yellow compound was obtained instead of the corresponding colorless amino derivative. Many years later, the structure of this compound, namely, cyclohexane-3-spiro-3,4-dihydro-1,2,4-benzotriazine, was demonstrated. From that time, the reduction of 2-nitrophenylhydrazones of different kinds of ketones, followed by air oxidation of the initially formed amino compounds, has represented a general way to synthesize a variety of 3,3-disubstituted 3,4-dihydro-1,2,4-benzotriazines. Many derivatives have been

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19

Khalil, El-Galil, Moged Berghot, and Mostafa Gouda. "Design, synthesis and antibacterial activity of new phthalazinedione derivatives." Journal of the Serbian Chemical Society 76, no. 3 (2011): 329–39. http://dx.doi.org/10.2298/jsc091122028k.

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Dibenzobarrelene (1) was utilized as the key intermediate for the synthesis of some new 2-substituted (1,4-dioxo-3,4,4e,5,10,10ahexahydro- 1H-5,10-benzeno-benzo[g]phthalazine: 2, 5a-d, 8a-c and 10. Condensation of 2 with benzaldehyde or anisaldehyde gave the corresponding acrylonitrile derivative 3a, b, respectively. Thiophene derivatives 4a, b were obtained via the Gewald reaction of 2 with cyclohexanone or pentanone, respectively. Treatment of 5d with acetyl chloride or p-toluenesulfonyl chloride afforded the corresponding esters 6, 7, respectively. Cyclization of 8a-c with formalin afforded

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20

Sepsey Für, Csilla Sepsey, Gergő Riszter, Áron SzigetvárI, et al. "Novel Ring Systems: Spiro[Cycloalkane] Derivatives of Triazolo- and Tetrazolo-Pyridazines." Molecules 26, no. 8 (2021): 2140. http://dx.doi.org/10.3390/molecules26082140.

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In orderto synthesize new pyridazine derivatives anellated with different nitrogen heterocyclic moieties, spiro[cycloalkane]pyridazinones were transformed into the corresponding thioxo derivatives via a reaction with phosphorus pentasulfide. The reaction of the formed 2,3-diazaspiro[5.5] undec-3-ene-1-thiones with hydrazine provided the corresponding 1-hydrazono-2,3-diazaspiro[5.5] undec-3-ene, whose diazotization led to the desired spiro[cyclohexane-1,8′-tetrazolo[1,5-b]pyridazines. The reaction of dihydropyridazinethiones with benzhydrazide afforded the corresponding 7H-spiro[[1,2,4]triazolo

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21

M, Shoaib. "Synthesis, Antibacterial and Antifungal Properties of Cyclohexane Tosyloxyimine Derivative." Open Access Journal of Microbiology & Biotechnology 4, no. 3 (2019): 1–4. http://dx.doi.org/10.23880/oajmb-16000150.

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Due to increasing antimicrobial resistance, functionally substituted cyclohexane derivatives are being explored as potential antimicrobial agents. Reaction of diethyl 4 - hydroxy - 6 - (hyd - roxyimino) - 4 - methyl - 2 - phenylcyclohexane - 1,3 - dicarboxylate with 4 - toluene sulfonyl chloride in boiling acetone in the presence of equimolar triethylamine resulted in formation of diethyl - 4 - hydroxy - 4 - methyl - 2 - phenyl - 6 - ((tosyloxy)imino) cyclohexane - 1,3 - dicarboxylate. The structure of novel compound was characterized by 1 H and 13 C NMR spectra and elemental analysis was perf

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22

Moskvina, Viktoria, Olexander Turov, Tetyana Shokol, and Volodymyr Khilya. "Synthesis and NMR spectroscopy investigations of functionalized spiropyranochromenediones and their spirothiadiazole derivatives." Ukrainica Bioorganica Acta 16, no. 2 (2021): 18–22. http://dx.doi.org/10.15407/bioorganica2021.02.018.

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This investigation focuses on the synthesis of spiropyranoneoflavones and the modification of obtained compounds at the exocyclic oxygen atom. Kabbe cyclization of 6-acetyl-7‑hydroxy-8-methyl-4-phenyl-2H-chromene-2-one with cyclohexanone or cyclopentanone in the presence of pyrrolidine provided 10-methyl-4-phenyl-2H-spiro[cyclohexane(cyclopentane)-1’,8-pyrano[3,2-g]chromene]-2,6(7H)-diones. Their new functionalized derivatives with thiosemicarbazide residues were synthesized. Acetylation of obtained thiosemicarbazones with acetic anhydride proceeded via cyclization of thiosemicarbazide fragmen

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23

Jurado, Sergio, Beatriz Domínguez-Pérez, Ona Illa, Jan Balzarini, Félix Busqué та Ramon Alibés. "Enantiocontrolled Preparation of ϒ-Substituted Cyclohexenones: Synthesis and Kinase Activity Assays of Cyclopropyl-Fused Cyclohexane Nucleosides". International Journal of Molecular Sciences 23, № 17 (2022): 9704. http://dx.doi.org/10.3390/ijms23179704.

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The enantioselective preparation of the two isomers of 4-hydroxy-2-cyclohexanone derivatives 1a,b was achieved, starting from a common cyclohexenone, through asymmetric transfer hydrogenation (ATH) reactions using bifunctional ruthenium catalysts. From these versatile intermediates, a stereoselective route to a cytosine analogue built on a bicyclo [4.1.0]heptane scaffold is described. Nucleoside kinase activity assays with this cyclopropyl-fused cyclohexane nucleoside, together with other related nucleosides (2a–e), were performed, showing that thymine- and guanine- containing compounds have a

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24

Ismayilova, S. V. "SYNTHESIS OF AMINOMETHOXY DERIVATIVES OF CYCLOHEXANOL AND STUDYING THEM AS BACTERICIDE INHIBITORS." Azerbaijan Chemical Journal, no. 2 (June 2, 2022): 11–17. http://dx.doi.org/10.32737/0005-2531-2022-2-11-17.

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Based on cyclohexanol, cyclic amines (piperidine, morpholine, hexamethyleneimine), and formaldehyde, new Mannich bases have been synthesized. The reaction was carried out at a temperature of 78–800C for 4–5 h in a benzene solution at an equimolar ratio of the starting components. The yield of compounds was 69–75%. The physicochemical data of the synthesized compounds were determined. The composition and structure of the target products were confirmed by elemental analysis, IR, 1H and 13C NMR spectroscopy, and mass spectrometry. Their effect on the vital activity of sulfate-reducing bacteria of

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25

Santos, Marina, and Graciela M. Escandar. "Cyclodextrin-Induced Room-Temperature Phosphorescence of 1-Bromo-2-naphthol upon Formation of Ternary Complexes." Applied Spectroscopy 55, no. 11 (2001): 1483–88. http://dx.doi.org/10.1366/0003702011953900.

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The inclusion constant for the 1:1 binary complex between 1-bromo-2-naphthol and β-cyclodextrin in aqueous solution was determined by a spectrofluorimetric method. On the basis of MO calculations, a possible structure of this complex was proposed and compared with those formed by two related naphthol derivatives. After the addition of different alcohols (linear, branched, and cyclic) to the 1-bromo-2-naphthol–β-cyclodextrin solution, a significant enhancement of the room-temperature phosphorescence (RTP) was observed. Both the formation constants and stoichiometries of the formed ternary compl

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26

Issam, A. M., Huda Salah Kareem, Muhsin Jaber Jweeg, et al. "Development, Comprehensive Characterization, and Antimicrobial Activity Evaluation of a Novel Class of Symmetrical 1,3-Benzoxazine Derivatives." Polish Journal of Chemical Technology 26, no. 4 (2024): 104–13. https://doi.org/10.2478/pjct-2024-0046.

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Abstract Completely symmetrical 6,6’-cyclohexane-1,1-diyl bis (3-substituted-3,4-dihydro-2H-1,3-benzoxazine) synthesized compounds have been able by a two-step process that yields a large amount of the compound. First, phenol and cyclohexanone were subjected to the Friedel-Craft process to produce 1,1’-bis(4-hydroxyphenyl) cyclohexane. The reaction between the bisphenol and formaldehyde and several primary amines produced unique symmetrical 1,3-benzoxazine compounds. Several spectroscopic methods, such as Fourier transform infrared spectroscopy, nuclear magnetic resonance (1H and 13C), GCMS sp

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27

Cadierno, Victorio, M. Pilar Gamasa, José Gimeno та Elena Lastra. "Unusual activation of 1-ethynyl-1-cyclohexanol by [RuCl(η5-C9H7)(PPh3)2]: synthesis and reactivity of the allenylidene derivative [Ru{CCC(C13H20)}(η5-C9H7)(PPh3)2][PF6]". Journal of the Chemical Society, Dalton Transactions, № 18 (1999): 3235–43. http://dx.doi.org/10.1039/a904744a.

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28

Kassem, Asmaa F., Fatimah Alshehrei, Eman M. H. Abbas, and Thoraya A. Farghaly. "Synthesis of Azoloquinazolines and Substituted Benzothiazepine as Antimicrobial Agents." Mini-Reviews in Medicinal Chemistry 20, no. 5 (2020): 418–29. http://dx.doi.org/10.2174/1389557519666190603091101.

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Background & Objective:Quinazolines and their fused systems are noteworthy in pharmaceutical chemistry due to their wide range of biological activities.Methods:A direct and efficient approach for the synthesis of new series of fused quinazolines with triazole, thiazole, benzimidazole and tetrazole has been preceded via the reaction of quinazoline thione derivative with halogenated compounds or cyclocondensation of arylidene of quinazoline derivative with heterocyclic amines. Also, dibenzo[b,e][1,4]thiazepine derivatives was synthesized through the reaction of 2,6-bis-(2-chloro-benzylidene)

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29

N.M., Fawzy, M. Nasef A., M.M.E-Baroudy, and Mohsen M. Soliman Abdel. "Synthesis of novel [4, 9-dimethoxy-5H-furo [3, 2-g] chromen-5-one] derivatives with antiproliferative potency towards breast and hepatic cancer cell lines." Chemistry Research Journal 2, no. 5 (2017): 309–19. https://doi.org/10.5281/zenodo.13952219.

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Chromen derivative (2) was obtained by the reaction of [cyclohexyl isocyanide, furochromone carbaldehyde (1), cyclohexane-1, 3-dione]. Also, reaction of compound (2) in the presence of semicarbazide hydrochloride to proceed the compound (3) which react with selenium dioxide to form compounds (4). In one-step, the condensation of cyclohexyl isocyanide, furochromone carbaldehyde (1) and pentane-2-dionein pipredine was given compound (5). The mixture of furochromone carbaldehyde (1), barbaturic/or thio-barbaturic acid and cyclohexyl isocyanide was afforded the corresponding compounds (6<sub>a,b</

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30

S. AL-Rawi, Muna, Huda A. Hassan, Dheefaf F. Hassan та Ismaeel Y. Majeed. "New Series of Substituted Heterocyclics Derived from α , β – Unsaturated Ketone and Their Cytotoxic Activity Tumor Cell Lines". Oriental Journal of Chemistry 34, № 6 (2018): 2826–31. http://dx.doi.org/10.13005/ojc/340620.

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The aldol condensation of 2-acetylnaphthalene with 9-anthracene carboxaldehyde afforded α, β-unsaturated keton (1) . New heterocyclic compounds containing: cyclohexenone[2], indazole[3], pyrimidinethion [4], thiazolo fused pyrimidine[5], isoxazoline[6], substituted pyrazoline[7]a-d and pyrimidinone[8] rings system were synthesized from α, β-unsaturated keton[1]. Cyclization of [1] with ethylacetoacetate gave the mentioned heterocycle cyclohexanone [2]. The cyclo condensation of [2] with hydrazine gave the new indazole derivative [3]. furthermore, the reation of [1]with thiourea gives thiopyrmi

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31

Kelly, John M., Guenter Quack, and Michael M. Miles. "In Vitro and In Vivo Activities of Aminoadamantane and Aminoalkylcyclohexane Derivatives against Trypanosoma brucei." Antimicrobial Agents and Chemotherapy 45, no. 5 (2001): 1360–66. http://dx.doi.org/10.1128/aac.45.5.1360-1366.2001.

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ABSTRACT We reported recently that the bloodstream form of the African trypanosome, Trypanosoma brucei, is sensitive to the anti-influenza virus drug rimantadine. In the present report we describe the trypanocidal properties of a further 62 aminoadamantane and aminoalkylcyclohexane derivatives. Seventeen of the compounds were found to be more active than rimantadine, with four inhibiting growth in vitro of T. brucei by >90% at concentrations of 1 μM. The most active derivative (1-adamantyl-4-amino-cyclohexane) was about 20 to 25 times more effective than rimantadine. We observed a correlati

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32

Cronholm, T. "Effect of ethanol on the redox state of the coenzyme bound to alcohol dehydrogenase studied in isolated hepatocytes." Biochemical Journal 248, no. 2 (1987): 567–72. http://dx.doi.org/10.1042/bj2480567.

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Hepatocytes were isolated from fed female rats and incubated with a redox indicator system consisting of cyclohexanone and unlabelled or perdeuterated cyclohexanol. The concentrations and deuterium contents of these were measured by g.l.c. and g.l.c.-m.s. of oxime t-butyldimethylsilyl derivatives. The equilibrium composition represented the redox state of the coenzyme bound to alcohol dehydrogenase, since 4-methylpyrazole inhibited the interconversion. Reduction appeared to be catalysed to a small extent also by an NADPH-dependent aldehyde reductase. The NADH/NAD+ ratio on alcohol dehydrogenas

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Haridas, Shyamkumar V., Oleksandr Shyshov, and Max von Delius. "Supramolecular Polymerization of all-cis-Fluorinated Cyclohexanes: Influence of Side Chains." Organic Materials 5, no. 03 (2023): 166–74. http://dx.doi.org/10.1055/s-0043-1761314.

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Custom-designed materials based on supramolecular polymers are of interest for applications in organic electronics and biomedicine. Recently, we have shown that derivatives of the highly polar compound all-cis hexafluorocyclohexane undergo seeded polymerization and can therefore be used to prepare soluble nanofibers with controlled length. In this work, we aimed to explore the scope of this process. We studied the supramolecular polymerization of six all-cis-fluorinated cyclohexane monomers, with five differing in the solubilizing side chains and one in the secondary supramolecular binding sit

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Luo, Xiaowei, Xuefeng Zhou, and Yonghong Liu. "Nitrogenous Compounds Produced by the Deep Sea Derived Fungus Leptosphaeria sp. SCSIO 41005." Natural Product Communications 13, no. 6 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300606.

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Four nitrogenous compounds, including two new compounds methyl-4-((1-hydroxy-3-methylpentan-2-yl)amino)–3-methyl-4-oxobutanoate (1), 4-((1-acetoxy-3-methylpentan-2-yl)amino)–3-methyl-4-oxobutanoic acid (2), and two amino acid derivatives (3, 4), were isolated from the deep sea derived fungus Leptosphaeria sp. SCSIO 41005, together with a cyclohexanone derivative (5) as new natural compound and other three known compounds (6–8). Their structures were elucidated by means of comprehensive 1D, 2D NMR and HR-ESI-MS spectroscopic methods. All the compounds were evaluated for their cytotoxic and anti

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Huppatz, John L., та John E. Casida. "Acetohydroxyacid Synthase Inhibitors: N-Phthalyl-ʟ-valine Anilide and Related Compounds". Zeitschrift für Naturforschung C 40, № 9-10 (1985): 652–56. http://dx.doi.org/10.1515/znc-1985-9-1010.

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Abstract The potency of ʟ-valine as an inhibitor of Zea mays acetohydroxyacid synthase (AHAS) is increased more than 80110-fold on conversion to its N-phthalyl anilide derivative which is active at 2 µᴍ. The ᴅ-valine, α-aminobutyric acid, isoleucine and phenylalanine analogs are 11- to 43-fold less potent, and similar N-phthalyl anilide derivatives of other branched-chain amino acids are essentially inactive. Full potency is retained on replacing the phthalimide moiety of the valine anilide with cyclohexane-1,2-dicarboximide or 1-cyclohexene-1.2-dicarboximide groups and partial activity with 4

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Mohrle, Hans, Thomas Platzek, Romanus Wille, and Detlef Wendisch. "Trisubstituted Cyclohexanes / Trisubstituted Cyclohexanes." Zeitschrift für Naturforschung B 40, no. 4 (1985): 524–33. http://dx.doi.org/10.1515/znb-1985-0415.

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C-Tertiarv vinylketones or the corresponding masked vinylketone derivatives react with pyrrolidin-2-one in the system sodium hydride.dimethylsulfoxide to substituted cyclohexanes of the 1,3.5- and sometimes additionally of the 1,2.4-type. Only acetophenone Mannich bases bearing a p-hydroxy or a dimethylamino group failed in cyclization.

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37

Mohareb, Rafat, and Hosam Moustafa. "Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities." Acta Pharmaceutica 61, no. 1 (2011): 51–62. http://dx.doi.org/10.2478/v10007-011-0001-y.

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Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities The aim of the work was to synthesize heterocyclic compounds from 2-aminoprop-1-ene-1,1,3-tricarbonitrile and to study their antitumor activities. The title reagent reacted with cyclohexanone to give the ethylidene derivative 2. The reactivity of the latter product towards different chemical reagents was studied to give tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives. The newly syn

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38

Hamama, Wafaa S., Mohamed A. Ismail, Hana’a A. Al-Saman, and Hanafi H. Zoorob. "Convenient Selective Synthesis of Substituted Pyrido[2,3-d]pyrimidones and Annulated Derivatives." Zeitschrift für Naturforschung B 62, no. 1 (2007): 104–10. http://dx.doi.org/10.1515/znb-2007-0115.

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The reaction of 6-aminouracil (1) with the appropriate α,β -unsaturated ketones, gave the corresponding pyrido[2,3-d]pyrimidin-2,4-diones 3, 6, 8 and 10, respectively. Treatment of 1 with salicylaldehyde, 6-carboethoxy-3,5-diphenyl-2-cyclohexenone (13) or 2,6- bis(phenylmethylidene)cyclohexanone (15) afforded the corresponding pyrimido[4,5-d]quinoline- 2,4-diones 12, 14 and 16, respectively. Furthermore, a pyrido[2,3-d]pyrimidine incorporating 3,2’- bis(quinoline) derivative 18 was synthesized. Annulation of pyrido[2,3-d]pyrimidine with pyrazole or imidazole moieties was achieved via reaction

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39

S.V. Ismayilova, S. V. Ismayilova. "AMINOMETHOXY DERIVATIVES OF CYCLOHEXANOL AS BIOCORROSION INHIBITORS." Azerbaijan Journal of Chemical News 04, no. 01 (2022): 54–59. http://dx.doi.org/10.32010/ajcn05012022-54.

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Based on cyclohexanol, aliphatic amines (diethylamine, dipropylamine, dibutylamine, dihexylamine), and formaldehyde, new Mannich bases have been synthesized. The reaction was carried out at a temperature of 78–80°C for 4–5 h in a benzene solution at an equimolar ratio of the starting components. The yield of compounds was 63–80%. The physicochemical data of the synthesized compounds were determined. The composition and structure of the target products were confirmed by elemental analysis, IR, 1H and 13C NMR spectroscopy. Their influence on the vital activity of sulfate-reducing bacteria (SRB)

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Oladimeji, Olawale Hakeem. "A Cycloalkanol from Derivatization Studies on Vanillin: Evaluation of Antioxidant Activity of Obtained Derivatives." Journal of Pharmaceutical Research Science & Technology 6, no. 1 (2022): 17–25. http://dx.doi.org/10.31531/jprst.1000157.

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Background: Vanillin is a white monoclinic crystalline compound whose chemical nomenclature is p-hydroxy-m-methoxy benzaldehyde. It is a phenolic aldehyde with a pleasant flavor and popularly found in vanilla beans and roasted coffee amongst many other sources. It serves as in addition; it possesses antitumor and particularly antioxidant activity which formed the essence of this study. Objectives: The insidious presence of free oxygenated and nitrogen radicals in the human body has become a worrisome concern. These chemical species continue to plague the human cells, tissues and organs resulti

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Oladimeji, OH Idiong ES Joseph UA et al. "A Cycloalkanol from Derivatization Studies on Vanillin: Evaluation of Antioxidant Activity of Obtained Derivatives." Journal of Pharmaceutical Research Science & Technology 6, no. 1 (2022): 17–25. https://doi.org/10.31531/jprst.1000157.

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Background: Vanillin is a white monoclinic crystalline compound whose chemical nomenclature is p-hydroxy-m-methoxy benzaldehyde. It is a phenolic aldehyde with a pleasant flavor and popularly found in vanilla beans and roasted coffee amongst many other sources. It serves as in addition; it possesses antitumor and particularly antioxidant activity which formed the essence of this study.  Objectives: The insidious presence of free oxygenated and nitrogen radicals in the human body has become a worrisome concern. These chemical species continue to plague the human cells, tissues and organs r

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42

N., MISHRA, SEN M., and NAYAK A. "Studies on Thiazolidinone. Part-XVIII. Synthesis of Thiazolidinone Derivatives from Benzosuberone and Cyclohexanone." Journal of Indian Chemical Society Vol. 67, April 1990 (1990): 353–55. https://doi.org/10.5281/zenodo.6202040.

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Department of Chemistry, Sambalpur University, Jyotivihar, Sambalpur-768 017 <em>Manuscript received 13 Aprtl 1989, revised 6 September 1989, accepted 21 November 1989</em> Studies on Thiazolidinone. Part-XVIII. Synthesis of Thiazolidinone Derivatives from Benzosuberone and Cyclohexanone

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43

Lloyd, Matthew G., Mariantonietta D'Acunto, Richard J. K. Taylor та William P. Unsworth. "A selective C–H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products". Organic & Biomolecular Chemistry 14, № 5 (2016): 1641–45. http://dx.doi.org/10.1039/c5ob02579f.

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A regio- and stereoselective one-pot C–H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives.

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44

Shikhverdieva, N. T., U. A. Mammedova, and N. A. Zeynalov. "THE SCIENTIFIC BASIS OF INDUSTRIAL APPLICATION OF THE PROCESS OF SELECTIVE HYDROGENATION OF BENZENE IN DIFFERENT CATALYTIC SYSTEMS." Azerbaijan Chemical Journal, no. 3 (September 19, 2023): 39–52. http://dx.doi.org/10.32737/0005-2531-2023-3-39-52.

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Pollution of the environment with substances obtained in the production of oil and other products in various industries forces us to take measures to solve environmental problems that have become relevant in recent years. Arenes, belonging to the class of petroleum-derived aromatic hydrocarbons, are very life-threatening substances due to their carcinogenic effects. In this regard, one of the important issues is the release of benzene, a special representative of arenes, from its carcinogenic effect as a toxic and volatile compound, and its use in the production of cyclohexane, which is the ma

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45

N., MISHRA, SEN M., and NAYAK A. "Studies on Thiazolidinone. Part-XVIII. Synthesis of Thiazolidinone Derivatives frem Benzosuberone and Cyclohexanone." Journal of Indian Chemical Society Vol. 67, April 1990 (1990): 353–55. https://doi.org/10.5281/zenodo.6203509.

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Department of Chemistry, Sambalpur University, Jyotivihar, Sambalpur-768-017 <em>Manuscript received 12 April 1989, revised 6 September 1989, accepted 21 November 1989</em> Studies on Thiazolidinone. Part-XVIII. Synthesis of Thiazolidinone Derivatives frem Benzosuberone and Cyclohexanone   

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46

Hafez, Hend N., Abdel-Rhman B. A. El-Gazzar, and Magdi E. A. Zaki. "Simple approach to thieno[3,2-d]pyrimidines as new scaffolds of antimicrobial activities." Acta Pharmaceutica 66, no. 3 (2016): 331–51. http://dx.doi.org/10.1515/acph-2016-0029.

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Abstract 6ʹ-(4-Chlorophenyl)-spiro[cyclohexane-1,2ʹ-thieno[3,2-d][1,3] oxazin]-4ʹ(1ʹH)-one (1) was synthesized and used as a starting material for the synthesis of a novel series of spiro compounds having biologically active sulfonamide 2a-e and 3ʹ-(4-acetylphenyl)-6ʹ- (4-chlorophenyl)-1ʹH-spiro[cyclohexane-1,2ʹ-thieno[3,2-d] pyrimidine-4ʹ(3ʹH)-one (3). Compound 2a was used as a key intermediate for the synthesis of sulfonyl carbothioamide derivatives 4a-c. Also, compound 3 was used as an intermediate for the synthesis of 3ʹH-spiro[cyclohexane-1,2ʹ-thieno[3,2-d]pyrimidin]-3ʹ-yl] phenyl}-2-imin

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Osante, Iñaki, Carlos Cativiela, Jaime Gracia-Vitoria та Ángel Carretero. "Diastereopure Synthesis of Novel Cyclohexane-Ring-Based Constrained Lanthionine and α-Methyllanthionine through an SN2 Reaction with a β-Bromoalanine as a Key Step". Synlett 31, № 04 (2020): 383–87. http://dx.doi.org/10.1055/s-0039-1690790.

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Here we report the diastereopure synthesis of a novel protected lanthionine derivative substituted with a cyclohexane ring as well as the diastereopure synthesis of an α-methyllanthionine derivative. By starting from enantiopure α,β-cyclohexane-substituted cystine, or α-methylcysteine, we designed a straightforward route that permits the preparation of orthogonally protected modified lanthionines in diastereopure form. The key step of the methodology is the formation of a thioether bond through the use of an β-bromoalanine derivative. The strategy developed should be valuable in the preparatio

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48

Konrad, David B., Klaus-Peter Rühmann, Hiroyasu Ando, et al. "A concise synthesis of tetrodotoxin." Science 377, no. 6604 (2022): 411–15. http://dx.doi.org/10.1126/science.abn0571.

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Tetrodotoxin (TTX) is a neurotoxic natural product that is an indispensable probe in neuroscience, a biosynthetic and ecological enigma, and a celebrated target of synthetic chemistry. Here, we present a stereoselective synthesis of TTX that proceeds in 22 steps from a glucose derivative. The central cyclohexane ring of TTX and its α-tertiary amine moiety were established by the intramolecular 1,3-dipolar cycloaddition of a nitrile oxide, followed by alkynyl addition to the resultant isoxazoline. A ruthenium-catalyzed hydroxylactonization set the stage for the formation of the dioxa-adamantane

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49

Kósa, Csaba, Jaroslav Mosnáček, Adela Bílešová, et al. "Synthesis, Oxidation and Photophysical Properties of Novel Derivatives of Acyclic Aromatic Amines." Collection of Czechoslovak Chemical Communications 72, no. 9 (2007): 1255–68. http://dx.doi.org/10.1135/cccc20071255.

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Conjugated acyclic arylamine derivatives, N-(4-methylphenyl)-N-(2-methyl-1-phenylpropyl)amine and N-(4-methoxyphenyl)-N-(2-methyl-1-phenylpropyl)amine, have been synthesized and characterized. Their photophysical properties have been investigated in polar methanol and non-polar cyclohexane solutions, and in PS and PMMA polymer matrices. The influence of the environment polarity as well as of the substituent in para-position of the aryl on the absorption, emission spectra and the fluorescence quantum yield has been studied. In the absorption and emission spectra, the observed absorption and emi

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Samshuddin, Seranthimata, Jerry P. Jasinski, Ray J. Butcher, et al. "Three closely-related cyclohexanols (C35H27X2N3O3;X= F, Cl or Br): similar molecular structures but different crystal structures." Acta Crystallographica Section C Structural Chemistry 70, no. 10 (2014): 953–59. http://dx.doi.org/10.1107/s2053229614019937.

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Three highly-substituted cyclohexanol derivatives have been prepared from 2-acetylpyridine and 4-halogenobenzaldehydes under mild conditions. (1RS,2SR,3SR,4RS,5RS)-3,5-Bis(4-fluorophenyl)-2,4-bis(pyridine-2-carbonyl)-1-(pyridin-2-yl)cyclohexanol, C35H27F2N3O3, (I), (1RS,2SR,3SR,4RS,5RS)-3,5-bis(4-chlorophenyl)-2,4-bis(pyridine-2-carbonyl)-1-(pyridin-2-yl)cyclohexanol acetone 0.951-solvate, C35H27Cl2N3O3·0.951C3H6O, (II), and (1RS,2SR,3SR,4RS,5RS)-3,5-bis(4-bromophenyl)-2,4-bis(pyridine-2-carbonyl)-1-(pyridin-2-yl)cyclohexanol, C35H27Br2N3O3, (III), all crystallize in different space groups,viz

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