Academic literature on the topic 'Cyclohexanone Thiosemicarbazone'

Cyclohexane-1,2-bis(thiosemicarbazone) (CHTSC) was synthesized via the condensation reaction of cyclohexane-1,2-dione and thiosemicarbazide. Series of metal complexes of the prepared lig-and, of general formula [M(CHTSC)(NO3)2], were reported. The prepared coordination complex-es were characterized and their structures elucidated using different techniques. These showed that all complexes are octahedral geometries. The kinetics of the formation of these complexes have been investigated using stopped-flow spectrophotometry. These studies revealed that the reactions are completed on the second’s timescale with 1st-order dependence (either on the con-centration of metal salt or on the concentration of CHTSC).

The synthesis of a new tridentate Schiff-base thiosemicarbazone ligand (HL) that derived from the reaction of ((R)-2-((4-(dimethylamino)phenyl)((2-nitrophenyl)amino)methyl)-5,5-di methyl- cyclohexane-1,3-dione with thiosemicarbazide is reported. The reaction of the title ligand(E)-2-((R)-2-((R)-(4-(dimethylamino)phenyl)((2-nitrophenyl)amino)methyl)-5,5-dimethyl-3-oxocyclohexylidene)hydrazine-1-carbothioamide with selected metal ions of Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) gave the title monomeric complexes. Analytical and spectroscopic techniques were used, as required, to characterise the prepared compounds. These include; elemental microanalysis, 1H, 13C-NMR and mass spectra, FT-IR and electronic spectra, magnetic susceptibility and conductance. These analyses revealed the formation of monomeric complexes of octahedral arrangement about Co(II); Cu(II) and square planar and tetrahedral geometry with the Ni(II) and Zn(II); Cd(II)) ions, respectively. Thermal stability (TGA-DSC) of HL and selected complexes were also explored. The antimicrobial activity of the title compounds (ligand and complexes) towards several microorganism (bacteria and fungi species) were examined. The collected data revealed the antimicrobial activity of the ligand was enhanced upon complex formation. Keywords: Thiosemicarbazone ligand, Metal complexes, Structural investigation, Thermal stability, Antimicrobial activity.

The direct two step synthesis of three new 2-hydrazono-4-oxo-5-thiazolidineacetic acids from thiosemicarbazide, the appropriate ketones (acetophenone, cyclopentanone, cyclohexanone) and maleic anhydride is described. The prepared acids were transformed, via their mixed anhydrides with ethyl carbonate, into their alkylamides in a one-pot procedure.

Department of Chemistry, Zakir Husain College, University of Delhi, J.L. Nehru Marg, New Delhi-110 002, India <em>E-mail </em>: schandra_OO@yahoo.com Fax : 91-11-234276530 <em>Manuscript received 11 August 2006, revised 22 January 2007, accepted 22 January 2007</em> A PVC-based membrane of copper(II)-cyclohexaneone thiosemicarbazone complex shows a Nernstain poteniometric response (with slope of 29.2 mV/decade) for copper(II) ions over a wide concentration range (1 x 10^-1 to 1 x 10^-9 <em>M</em>). The potential of the electrode is independent of pH in the range 2.0-7.0. It has a fast response of about 15 s and was used for a period of 2 months with good reproducibility.