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Journal articles on the topic 'Cyclohexylamine derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Chepur, S. V., S. E. Galan, M. S. Vakhviayanen, R. N. Khromov, and A. N. Semenov. "EXPERIMENTAL EVALUATION OF TOXICOMETRIC INDICATORS AND ANALGESIC ACTIVITY OF KAPPA-OPIOID RECEPTOR AGONISTS." Toxicological Review, no. 4 (August 1, 2020): 27–33. http://dx.doi.org/10.36946/0869-7922-2020-4-27-33.

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Data on the biological activity of kappa-opioid receptor agonists - derivatives of three groups of compounds: 1,2-cyclohexylamine, 1,2,3,4-piperidine, 1,2,4-piperazine are presented. On the examples of 1,2-cyclohexylamine and 1,2,4-piperazine derivatives, it has been shown that a decrease in the length of the carbon chain in the phenylalkyl substituent at the nitrogen atom is accompanied by a decrease in the analgesic activity and toxicity of compounds. The replacement of chlorine atoms in the 3 and 4 positions of the phenyl ring with fluorine atoms, which are more electronegative, leads to an

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2

Glushkov, V. A., O. S. P’yankova, L. V. Anikina, et al. "Synthesis and biological activity of cyclohexylamine derivatives." Pharmaceutical Chemistry Journal 40, no. 6 (2006): 298–302. http://dx.doi.org/10.1007/s11094-006-0114-7.

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3

Llona-Minguez, Sabin, and Simon P. Mackay. "Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0)." Beilstein Journal of Organic Chemistry 10 (June 11, 2014): 1333–38. http://dx.doi.org/10.3762/bjoc.10.135.

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A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules.

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4

Suzuki, Aya, Hiroyuki Miyamura, and Shū Kobayashi. "Highly Selective Reductive Cross-Amination between Aniline or Nitroarene Derivatives and Alkylamines Catalyzed by Polysilane-Immobilized Rh/Pt Bimetallic Nanoparticles." Synlett 30, no. 04 (2019): 387–92. http://dx.doi.org/10.1055/s-0037-1611341.

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Reductive cross-amination between imine intermediates generated through partial hydrogenation of aniline or nitroarene derivatives and alkylamines is an ideal method for obtaining N-alkylated cyclohexylamine derivatives; however, no such transformations have hitherto been established. Here, we report a highly selective reductive cross-amination using aniline derivatives and alkylamines catalyzed by heterogeneous Rh/Pt bimetallic nanoparticles under mild conditions. The catalyst was recovered and reused for five runs, keeping high activity. In this reaction, imine intermediates generated during

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5

Georgieva, Maya, Javor Mitkov, Lily Peikova, Plamen Peikov, and Alexander Zlatkov. "SYNTHESIS EVALUATION AND QUANTUM MECHANICAL CHARACTERIZATION OF CYCLOHEXYLAMINE CONTAINING DERIVATIVES OF METHYLXANTHINE." CBU International Conference Proceedings 4 (September 26, 2016): 879–87. http://dx.doi.org/10.12955/cbup.v4.868.

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The synthesis of methylxanthine derivatives could provide a sound approach to developing new analogues with similar or novel pharmacological profiles. The synthesis of six new compounds: two derivatives of 8-substituted-1,3,7-trimethylxanthine and four derivatives of 1-propyl-3,7-dimethylxanthine containing a cyclohexyl fragment, are presented. The structures were confirmed by elemental analyses using Furrier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) spectral data. The chemical reactivity of the new molecules was assessed, based on computed values for their el

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6

Zificsak, Craig A., Jay P. Theroff, Lisa D. Aimone, et al. "Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors." Bioorganic & Medicinal Chemistry Letters 21, no. 13 (2011): 3877–80. http://dx.doi.org/10.1016/j.bmcl.2011.05.040.

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7

Castañeta, Grover, Rodrigo Villagomez, Efrain Salamanca, et al. "Microwave-Assisted Semisynthesis and Leishmanicidal Activity of Some Phenolic Constituents from Lichens." Separations 10, no. 10 (2023): 524. http://dx.doi.org/10.3390/separations10100524.

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Leishmaniasis is considered one of the most untreated tropical diseases in the world. In this study, we investigated the in vitro leishmanicidal activity and cytotoxicity of various isolated lichen substances, including atranorin (1), usnic acid (2), gyrophoric acid (3), salazinic acid (4), galbinic acid (5), and parietin (6), and some semi-synthetic imine derivatives of usnic acid (7, 8, 9) and atranorin (10, 11, 12, 13). Imine condensation reactions with hydrazine and several amines were assisted by microwave heating, an efficient and eco-friendly energy source. The most interesting result w

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8

Čeřovský, Václav, Taťána Saks, and Karel Jošt. "Papain-catalyzed synthesis of 2-naphthylamides of N-acylamino acids and dipeptides." Collection of Czechoslovak Chemical Communications 52, no. 9 (1987): 2309–16. http://dx.doi.org/10.1135/cccc19872309.

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2-Naphthylamides of several N-acylamino acids were prepared by papain-catalyzed condensation reaction in acidic medium. Under the same conditions, papain catalyzed the synthesis of peptide bond between benzyloxycarbonylglycine and phenylalanine 2-naphthylamide and between benzyloxycarbonylserine and tyrosine 2-naphthylamide. Phenylalanine 2-naphthylamide was also acylated with benzyloxycarbonyl glycine methyl ester in an alkaline medium. For comparison, papain-catalyzed condensations of benzyloxycarbonyl-S-benzylcysteine or benzyloxycarbonylalanine with aniline and its derivatives, benzylamine

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9

MOHAMED, ABBAS METWALLY, and M. KHALIL ABDEL-GALIL. "Synthesis of Azabicyclo[3.3.1 ]nonanes and Dibenzo[b,d]pyrans from 3-Aryl-2,4-dicarboethoxy-5-hydroxy-5-methyl-cyclohexanones as Potential Antimicrobial Agents." Journal of Indian Chemical Society Vol. 65, Nov 1988 (1988): 766–67. https://doi.org/10.5281/zenodo.6087498.

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Department of Chemistry, Faculty of Science, University of Mansoura, Mansoura, Egypt <em>Manuscript received 19 January 1988, revised 27  May 1988, accepted 2 August 1988</em> Double Mannich reaction or 1a, c with formalin and benzylamine or cyclohexylamine gave 3-azabicyclo [3 3.1] nonane derivatives (2a, b), while  the Pechmann reaction of 1a, c gave the dlbenzopyrans (4, 5). The structures of the compounds have been confirmed by ir, pmr and mass spectral data.

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10

Štetinová, Jarmila, Adolf Jurášek, Jaroslav Kováč, Miloslava Dandárová, and Oľga Rajniaková. "Synthesis and properties of 4-alkylaminomethyl and 4-alkoxymethyl derivatives of 5-methyl-2-furancarboxylic acid." Collection of Czechoslovak Chemical Communications 51, no. 10 (1986): 2186–92. http://dx.doi.org/10.1135/cccc19862186.

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New β-substituted amines and ethers of the furan series (II-V) were prepared by reaction of methyl 4-bromomethyl-5-methyl-2-furancarboxylate (I) with nucleophiles such as pyrrolidine, piperidine, morpholine, N-phenylpiperazine, cyclohexylamine, 2-methylcyclohexylamine, N-ethylaniline, p-toluidine, ethanol, butanol and salicylaldehyde. The structure of the products was confirmed by their analytical and spectral data. Kovats indices I for the products were determined using gas-liquid chromatography.

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11

Döring, Cindy, and Peter G. Jones. "Aminkomplexe des Goldes, Teil 9: Gold(I)-halogenid-Komplexe mit primären und azyklischen sekundären Aminen und ihre Oxidation zu Gold(III)-Derivaten." Zeitschrift für Naturforschung B 73, no. 1 (2018): 43–74. http://dx.doi.org/10.1515/znb-2017-0182.

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AbstractThe reaction of (tht)AuX (X=Cl or Br; tht=tetrahydrothiophene) with various primary amines L leads to products of the form [L2Au]+X−. Packing diagrams of the corresponding structures are dominated by N–H···X hydrogen bonds and (in some cases) aurophilic contacts. The cyclohexylamine derivative was already known as its dichloromethane ⅔-solvate; we have isolated the solvent-free compound and its pentane ¼-solvate, which all show different packing patterns. With acyclic secondary amines, the products are more varied; LAuX and [L2Au]+[AuX2]− were also found. These gold(I) products were ge

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12

Siirola, Elina, Francesco G. Mutti, Barbara Grischek, et al. "Asymmetric Synthesis of 3-Substituted Cyclohexylamine Derivatives from Prochiral DiketonesviaThree Biocatalytic Steps." Advanced Synthesis & Catalysis 355, no. 9 (2013): 1703–8. http://dx.doi.org/10.1002/adsc.201201057.

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13

Patidar, Pankaj, Prerna Chaturvedi, and Neetesh Kumar Jain. "Synthesis, Characterization and Antidiabetic Activity of New Pyrimidine Fused Derivatives." International Journal of Medical Sciences and Pharma Research 8, no. 2 (2022): 45–49. http://dx.doi.org/10.22270/ijmspr.v8i2.37.

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Various evidences suggest that common health problem of modern society, viz. diabetes mellitus, obesity, cardiovascular diseases etc. The prevalence of diabetes mellitus in majority increases with age and obesity; over 20 % adults (≥ 60 years or older) have diabetes. Synthesis of starting materials by Noevenagel Condensation then A reaction mixture of different benzylidine propanednitriles 1a-d (10 mmol), alkylisothiourea salts (11.00 mmol) and sodium acetate anhydrous (2.50 g, 24.40 mmol) in pyridine (50 ml) was refluxed for 3 hrs, and crystallized from ethanol give compound 2a-d. then 2-Meth

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14

Kooli, Fethi, Yan Liu, Kais Hbaieb, and Rawan Al-Faze. "Preparation and catalytic activities of porous clay heterostructures from aluminium-intercalated clays: effect of Al content." Clay Minerals 52, no. 4 (2017): 521–35. http://dx.doi.org/10.1180/claymin.2017.052.4.09.

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AbstractPorous clay heterostructures were prepared from Al-intercalated clays, and they allowed the insertion of Al into the framework of intercalated silica in porous clay heterostructures (PCHs). This method has led to tuneable Al contents within the resulting porous clay heterostructures. X-ray fluorescence confirmed the presence of Al in the intercalated precursors and their derivatives (porous clay heterostructure materials) in various environments, as indicated by 27Al magic-angle spinning nuclear magnetic resonance. The Al porous clay heterostructures exhibited specific surface areas th

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15

Dawber, J. Graham, and Jeremy Massey-Shaw. "A nuclear magnetic resonance and molecular-modelling study of cyclohexylamine and several N-substituted derivatives and their hydrochloride salts." Journal of the Chemical Society, Perkin Transactions 2, no. 9 (1989): 1249. http://dx.doi.org/10.1039/p29890001249.

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16

Shahista Chuhann and Brij Kishore Sharma. "CP-MLR/PLS directed quantitative structure-activity relationship study on the histamine H3 receptor binding affinity: The cyclohexylamine based series." World Journal of Biology Pharmacy and Health Sciences 13, no. 2 (2023): 089–104. http://dx.doi.org/10.30574/wjbphs.2023.13.2.0074.

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The histamine H3 receptor binding affinities of cyclohexylamine derivatives has been analysed with the topological and molecular features from Dragon software. Analysis of the structural features in conjunction with the biological endpoints in combinatorial protocol in multiple linear regression (CP-MLR) led to the identification of 26 descriptors for modelling the activity. The study clearly suggested the role of atomic properties such as mass, electronegativity or charge content, polarizability, atomic van der Waals volume, average valence connectivity index chi-5 and absence of number of ac

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17

Hans, Morgan, Jan Lorkowski, Albert Demonceau, and Lionel Delaude. "Efficient synthetic protocols for the preparation of common N-heterocyclic carbene precursors." Beilstein Journal of Organic Chemistry 11 (November 25, 2015): 2318–25. http://dx.doi.org/10.3762/bjoc.11.252.

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The one-pot condensation of glyoxal, two equivalents of cyclohexylamine, and paraformaldehyde in the presence of aqueous HBF4 provided a straightforward access to 1,3-dicyclohexylimidazolium tetrafluoroborate (ICy·HBF4). 1,3-Dibenzylimidazolium tetrafluoroborate (IBn·HBF4) was obtained along the same lines. To synthesize 1,3-diarylmidazolium salts, it was necessary to isolate the intermediate N,N'-diarylethylenediimines prior to their cyclization. Although this additional step required more time and reagents, it led to a much more efficient overall process. It also proved very convenient to ca

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18

Shahista, Chuhann, and Kishore Sharma Brij. "CP-MLR/PLS directed quantitative structure-activity relationship study on the histamine H3 receptor binding affinity: The cyclohexylamine based series." World Journal of Biology Pharmacy and Health Sciences 13, no. 2 (2023): 089–104. https://doi.org/10.5281/zenodo.7948616.

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The histamine H<sub>3</sub> receptor binding affinities of cyclohexylamine derivatives has been analysed with the topological and molecular features from Dragon software. Analysis of the structural features in conjunction with the biological endpoints in combinatorial protocol in multiple linear regression (CP-MLR) led to the identification of 26 descriptors for modelling the activity. The study clearly suggested the role of atomic properties such as mass, electronegativity or charge content, polarizability, atomic van der Waals volume, average valence connectivity index chi-5 and absence

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19

Dashkin, Ratmir R., Tatiana Yu Vorobieva, Mary A. Seferyan, Daria V. Danilova, and Sergey N. Mantrov. "Method of synthesis of O-methyl-N-alkylcarbamate from amines and dialkylcarbonate." Butlerov Communications 59, no. 7 (2019): 31–36. http://dx.doi.org/10.37952/roi-jbc-01/19-59-7-31.

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A carbamates (urethanes) are an organic compounds with the general formula R'R''NCOOR are esters of carbamic acid and its derivatives. Due to their biological activity, carbamates are common as pesticides, insecticides, herbicides, and are used as drugs. Polyurethanes are widely used in industry. The main method of synthesis is the interaction of isocyanates with the corresponding alcohols or phenols, it is also possible to use urea, isocyanic acid or other methods, including the use of in-situ formed isocyanate. In the literature, N-alkyl-O-methylcarbamate is synthesized by reacting amines wi

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20

Evrard, Deborah A., Ping Zhou, Soo Y. Yi, et al. "Studies towards the next generation of antidepressants. Part 4: Derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor." Bioorganic & Medicinal Chemistry Letters 15, no. 4 (2005): 911–14. http://dx.doi.org/10.1016/j.bmcl.2004.12.064.

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21

Čižmáriková, R., S. Chudáčiková, J. Valentová, and A. Némethy. "Synthesis and enantioseparation of derivatives of propranolol." Acta Facultatis Pharmaceuticae Universitatis Comenianae 59, no. 1 (2012): 5–13. http://dx.doi.org/10.2478/v10219-012-0012-x.

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Synthesis and enantioseparation of derivatives of propranololPropranolol is one of the first prepared and in therapeutic praxis used beta- adrenolytics. In this paper novel derivatives of propranolol with cyclohexylamino and pyrrolidin-1-yl groups in hydrophilic part were prepared. HPLC-enantioseparation propranolol (as reference compound) and of the prepared derivatives has been achieved using a Chiralpak AD CSP based on the amylose tris (3,5-dimethylphenylcarbamate).(R)-enantiomer of the propranolol was prepared by stereoselective synthesis using Jacobsen catalyst.

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22

Mu, Li, Yuhang Liu, Huihong Luo, et al. "Determination of the stability of sodium cyclamate during deep-frying using HPLC." PLOS ONE 19, no. 8 (2024): e0308220. http://dx.doi.org/10.1371/journal.pone.0308220.

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The oil used to fry food is often used multiple times to reduce costs. However, when foods containing sweeteners are processed in this way, the sweeteners may produce substances harmful to the body as a result of repeated frying at high temperatures. This article investigated the stability of sodium cyclamate during deep-frying by HPLC using a pre-column derivatization method. The results showed that cyclohexylamine was a decomposition product of a standard sample of sodium cyclamate when deep-fried at 200°C for 25 min. A pre-column derivatization/HPLC method was established to determine cyclo

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23

McAuliffe, Joseph C., та Robert V. Stick. "β-Acarbose. III. The Attempted Alkylation of a 1-Epivalienamine Derivative with Various Carbohydrate Triflates". Australian Journal of Chemistry 50, № 3 (1997): 203. http://dx.doi.org/10.1071/c96153.

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Various carbohydrate triflates have been treated with cyclohexylamine and a 1-epivalienamine derivative to give some of the desired secondary amine, but mainly the product of a competing elimination reaction, namely a mixture of alkenes. When the reactions were conducted in the presence of potassium carbonate, novel carbohydrate carbamates were formed.

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Bálint, Erika, Eszter Fazekas, Gyorgy Pinter, et al. "Synthesis and Utilization of the Bis( > P(O)CH2)amine Derivatives Obtained by the Double Kabachnik–Fields Reaction with Cyclohexylamine; Quantum Chemical and X-Ray Study of the Related Bidentate Chelate Platinum Complexes." Current Organic Chemistry 16, no. 4 (2012): 547–54. http://dx.doi.org/10.2174/138527212799499822.

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25

Marandi, Ghasem. "Synthesis of 3-(Cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8- carboxylic Acids Via an Efficient Three-component Condensation Reaction between Cyclohexylisocyanide and 2-Aminopyridine-3-carboxylic Acid in the Presence of Aromatic Aldehyde." Combinatorial Chemistry & High Throughput Screening 21, no. 4 (2018): 298–301. http://dx.doi.org/10.2174/1386207321666180416153112.

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Aim and Objective: The reaction of cyclohexylisocyanide and 2-aminopyridine-3- carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2- arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without any prior activation. Material and Methods: The synthesized products have stable structures which have been characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis. Results: In continuation of our attempts

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26

Breen, C. "Thermogravimetric and infrared study of the desorption of butylamine, cyclohexylamine and pyridine from Ni- and Co-exchanged montmorillonite." Clay Minerals 26, no. 4 (1991): 487–96. http://dx.doi.org/10.1180/claymin.1991.026.4.04.

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AbstractThe acidity of Ni2+- and Co2+-exchanged montmorillonite has been probed using the diagnostic bases n-butylamine, cyclohexylamine and pyridine. Derivative thermograms for the desorption of pyridine from Ni2+- and Co2+-exchanged montmorillonite exhibited strong maxima at 40°, 90° and 360°C together with a weak maximum near 170°C The desorption maximum at 360°C is usually attributed to desorption of base from Bronsted acid sites. However, IR spectra of pyridine adsorbed on Ni2+- and Co2+-exchanged montmorillonite, at 250°C were dominated by intense bands near 1450 and 1607 cm−1 which are

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27

Isabel, Sánchez, Pujol Maria Dolors, Guillaumet Gérald, Massingham Roy, and Monteil André. "Synthesis of new piperidine and cyclohexylamino-spiro derivatives as potential anticalcium agents." Scientia Pharmaceutica 70, no. 2 (2002): 177–85. http://dx.doi.org/10.3797/scipharm.aut-02-19.

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Tilbrook, Matthew G., Robert V. Stick та Spencer J. Williams. "β-Acarbose. VII. Approaches Towards the Synthesis of Some N-Linked Carba-Oligosaccharides". Australian Journal of Chemistry 52, № 9 (1999): 885. http://dx.doi.org/10.1071/ch99030.

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3,4-Anhydro-1,6-dideoxy-1,6-episeleno-β-D-glucose was treated with cyclohexylamine to afford an amino diol which was subsequently converted into a cyclic carbamate, a compound shown to be a moderately successful glycosyl donor. Treatment of the same 3,4-anhydro sugar and the 1,6-epithio analogue with a 1-epivalienamine derivative afforded the corresponding secondary amines which were converted into the analogous cyclic carbamates. The epithio analogue was unsuccessful as a glycosyl donor, failing to glycosylate a carbohydrate alcohol. On the other hand, the episeleno compound appeared to funct

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29

Adhikari, Anup Kumar, Toni Grell, Peter Lönnecke, and Evamarie Hey-Hawkins. "Basicity of N -(Tetramesityltetraphosphacyclopentylidene)cyclohexylamine: An Unusual Diphospha(III)guanidine Derivative." European Journal of Inorganic Chemistry 2017, no. 45 (2017): 5329–33. http://dx.doi.org/10.1002/ejic.201700869.

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Adhikari, Anup Kumar, Toni Grell, Peter Lönnecke, and Evamarie Hey-Hawkins. "Basicity of N -(Tetramesityltetraphosphacyclopentylidene)cyclohexylamine: An Unusual Diphospha(III)guanidine Derivative." European Journal of Inorganic Chemistry 2017, no. 45 (2017): 5328. http://dx.doi.org/10.1002/ejic.201701329.

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Mamaghani, Manouchehr, Nosrat O. Mahmoodi, Farhad Shirini, Abbas Azimi-Roshan, and Azam Monfared. "“On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates)." Journal of Chemistry 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/125959.

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An expeditious, efficient, and ecofriendly ultrasound-promoted synthesis of a series of novel 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives (6a–k), as useful building block candidates for natural products and drugs, is reported. The target compounds were prepared by the reaction of alkyl or aryl carboxylic acid, various bisaldehydes and isocyanocyclohexane in water using one-pot isocyanide-based multicomponent approach. This efficient protocol without using any catalyst furnished the products in short reaction times (4-5 min) and excellent yiel

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T, Mavromoustakos. "Spectroscopic and Computational Study of the Ugi Cinnamic Adduct NGI25." Advance Research in Organic and Inorganic Chemistry (AROIC) 3, no. 1 (2022): 1–2. http://dx.doi.org/10.54026/aroic/1006.

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The structure assignment and conformational analysis of cinnamic derivative N-benzyl-N-(2-(cyclohexylamino)-2-oxoethyl) cinnamamide (NGI25) was carried out through Nuclear Magnetic Resonance (NMR) spectroscopy, Molecular Dynamics (MD) and Quantum Mechanics (QM), i.e., semiempirical and Density Functional Theory (DFT) calculations. Specifically, homonuclear (2D-COSY, 2D-NOESY) and heteronuclear (2D-HSQC, 2D-HMBC) spectra were obtained. Through them, the resonant values of the hydrogens and their constituent carbons were identified. After structure identification, NGI25 was subjected to computat

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André, C., P. Luger, S. Lotz, and W. P. Fehlhammer. "The crystal packing modes of three sterically overcrowded imidazole derivatives." Acta Crystallographica Section B Structural Science 52, no. 2 (1996): 369–75. http://dx.doi.org/10.1107/s0108768195011293.

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The crystal packing of racemic 4-cyclohexylamino-5-hydroxy-1,5-diphenyl-Δ3-imidazolin-2-one resembles the bilayered packing arrangements with alternating hydrophilic and hydrophobic layers observed in the crystal structures of lipids. The hydrophobic layers of the imidazolinone are built up individually by phenyl and cyclohexyl groups. In contrast, the corresponding 4-tert-butylamino derivative crystallizes optically resolved in a non-bilayer layer structure. This crystal packing is similar to the host-lattice of the inclusion compound formed by 9-(4-tert-butylphenyl)fluoren-9-ol and dioxane [

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Bąchor, Urszula, Adam Junka, Malwina Brożyna, and Marcin Mączyński. "The In Vitro Impact of Isoxazole Derivatives on Pathogenic Biofilm and Cytotoxicity of Fibroblast Cell Line." International Journal of Molecular Sciences 24, no. 3 (2023): 2997. http://dx.doi.org/10.3390/ijms24032997.

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The microbial, biofilm-based infections of chronic wounds are one of the major challenges of contemporary medicine. The use of topically administered antiseptic agents is essential to treat wound-infecting microorganisms. Due to observed microbial tolerance/resistance against specific clinically-used antiseptics, the search for new, efficient agents is of pivotal meaning. Therefore, in this work, 15 isoxazole derivatives were scrutinized against leading biofilm wound pathogens Staphylococcus aureus and Pseudomonas aeruginosa, and against Candida albicans fungus. For this purpose, the minimal i

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Senthil, K., K. Elangovan, A. Senthil, and G. Vinitha. "Synthesis, growth, optical, mechanical, thermal, dielectric and third order nonlinear optical properties of cyclohexylamine derivative single crystals." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 247 (February 2021): 119063. http://dx.doi.org/10.1016/j.saa.2020.119063.

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Winkler, Torsten, Rainer Herges, Peter G. Jones, and Ina Dix. "A tetrakis(secondary amide) derivative of quadricyclane: 3-isopropylidenetetracyclo[3.2.0.02,7.04,6]heptane-1,5,6,7-tetracarboxylic acid tetrakis(cyclohexylamide)." Acta Crystallographica Section E Structure Reports Online 59, no. 8 (2003): o1098—o1100. http://dx.doi.org/10.1107/s1600536803013692.

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Liu, Yu, Shi-Zhao Kang та Heng-Yi Zhang. "Synthesis of β-cyclodextrin derivative bearing a cyclohexylamino moiety and its inclusion complexation with organic dye molecules". Microchemical Journal 70, № 2 (2001): 115–21. http://dx.doi.org/10.1016/s0026-265x(01)00106-0.

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38

Ramos-Tomillero, Iván, Marisa K. Sánchez, Hortensia Rodríguez та Fernando Albericio. "Structure-Acid Lability Relationship of N-alkylated α,α-dialkylglycine Obtained via a Ugi Multicomponent Reaction". Molecules 26, № 1 (2021): 197. http://dx.doi.org/10.3390/molecules26010197.

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Using the classical Ugi four-component reaction to fuse an amine, ketone, carboxylic acid, and isocyanide, here we prepared a short library of N-alkylated α,α-dialkylglycine derivatives. Due to the polyfunctionality of the dipeptidic scaffold, this highly steric hindered system shows an interesting acidolytic cleavage of the C-terminal amide. In this regard, we studied the structure-acid lability relationship of the C-terminal amide bond (cyclohexylamide) of N-alkylated α,α-dialkylglycine amides 1a–n in acidic media and, afterward, it was established that the most important structural features

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39

Adhikari, Anup Kumar, Toni Grell, Peter Lönnecke, and Evamarie Hey-Hawkins. "Front Cover: Basicity of N -(Tetramesityltetraphosphacyclopentylidene)cyclohexylamine: An Unusual Diphospha(III)guanidine Derivative (Eur. J. Inorg. Chem. 45/2017)." European Journal of Inorganic Chemistry 2017, no. 45 (2017): 5327. http://dx.doi.org/10.1002/ejic.201701328.

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Maghsoodlou, Malek Taher, Nourallah Hazeri, Khatereh Khandan-Barani, Sayyed Mostafa Habibi-Khorasani, and Alireza Abedi. "Synthesis of 1-(Cyclohexylamino)-2-(aryl)pyrrolo[1,2-a]quinoline-3-carbonitrile Derivatives Using a Mild, Four-Component Reaction." Journal of Heterocyclic Chemistry 51, S1 (2014): E152—E155. http://dx.doi.org/10.1002/jhet.1913.

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41

Maghsoodlou, Malek Taher, Nourallah Hazeri, Khatereh Khandan-Barani, Sayyed Mostafa Habibi-Khorasani, and Alireza Abedi. "ChemInform Abstract: Synthesis of 1-(Cyclohexylamino)-2-(aryl)pyrrolo[1,2-a]quinoline-3-carbonitrile Derivatives Using a Mild, Four-Component Reaction." ChemInform 46, no. 9 (2015): no. http://dx.doi.org/10.1002/chin.201509211.

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Levent, Serkan, Betül Kaya Çavuşoğlu, Yusuf Özkay, and Zafer Asım Kaplancıklı. "Synthesis of 2-(5-(2-((5-(Cyclohexylamino)-1,3,4-Thiadiazol-2-yl)thio)ethyl)-1,3,4-Oxadiazol-2-yl) Derivatives and Their Antimicrobial Activity." Proceedings 1, no. 6 (2017): 637. http://dx.doi.org/10.3390/proceedings1060637.

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43

HYUN, M. H., and J. B. LEE. "ChemInform Abstract: A New Chiral Stationary Phase Derived from Cyclohexylamide Derivative of (S)-Naproxen for the Liquid Chromatographic Resolution of Enantiomers." ChemInform 27, no. 19 (2010): no. http://dx.doi.org/10.1002/chin.199619037.

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44

Colombo, Tina, Angela Paolini, Mario Finazzi, Eugenio Scanziani, Giancarlo Mandelli, and Maria Grazia Donelli. "Antitumoral Activity of the Oxazaphosphorine Derivative, Mafosfamide-Cyclohexylamine Salt (ASTA 7557) on a Murine Ovarian Reticular Cell Sarcoma and its Subline Resistant to Cyclophosphamide." Tumori Journal 72, no. 6 (1986): 637–42. http://dx.doi.org/10.1177/030089168607200617.

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The antitumor activity of mafosfamide (MFA), and its parent compound cyclophosphamide (CTX), was investigated against an ovarian reticular cell sarcoma growing i.m. in C57BI/6 mice (M5), which is very sensitive to CTX, and against a subline of this tumor (R16) resistant to CTX. MFA is the prototype of a class of oxazaphosphorines which do not require metabolic activation since under physiologic conditions they undergo rapid spontaneous hydrolyzation to the activated 4-hydroxyoxazaphosphorine and retain a spectrum of activity very similar to the parent compound. After a single dose (300 mg/kg ×

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Kouge, Katsushige, Yukari Katakai, Haruko Soma, et al. "Peptide Synthesis in Aqueous Solution. III. Synthesis and Biological Activity of Cyclohexylamide Derivatives of Peptides Related to a Molluscan Neuropeptide, FMRFamide (Phe–Met–Arg–Phe–NH2)." Bulletin of the Chemical Society of Japan 60, no. 12 (1987): 4351–56. http://dx.doi.org/10.1246/bcsj.60.4351.

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46

Hasegawa, Masatoshi, and Shunichi Horii. "Heat-Resistant Polymers with Intense, Visible Photoluminescence Functionality and Fluorescence Probing Application." Macromol 3, no. 2 (2023): 245–74. http://dx.doi.org/10.3390/macromol3020016.

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Heat-resistant polymers with an intense, visible photoluminescence (PL) functionality are presented. A polybenzoxazole (PBO) containing hexafluoroisopropylidene (HFIP) side groups exhibited an intense purple PL with a quantum yield, ΦPL, of 0.22 (22%), owing to the effectively disturbed concentration quenching (CQ) in the fluorophore units by the bulky HFIP side groups. The chain ends of a wholly cycloaliphatic polyimide (PI), derived from 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA) and 4,4′-methylenebis(cyclohexylamine) (MBCHA), were modified with conjugated monoamines. The PI deriv

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Shi, Yi, Bhuvaneswari Koneru, Warren Redfearn, Michael L. Miller, Lara Myers, and Anthony J. Di Pasqua. "Platinum(IV) cisplatin derivative trans, cis, cis-bis(heptanoato)amine(cyclohexylamine)dichloridoplatinum(IV) has an enhanced therapeutic index compared to cisplatin for the treatment of non-small cell lung cancer." Inorganica Chimica Acta 423 (November 2014): 215–19. http://dx.doi.org/10.1016/j.ica.2014.07.043.

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Wang, Chun-Jiang, Yi-Nan Lu, Chao Che, Guangjin Zeng, Xin Chang, and Xiu-Qin Dong. "Visible-Light-Enabled Stereoselective Synthesis of Functionalized Cyclohexylamine Derivatives via [4 + 2] Cycloadditions." Chemical Science, 2024. http://dx.doi.org/10.1039/d4sc00667d.

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An unprecedented intermolecular [4 + 2] cycloaddition of benzocyclobutylamines with α-substituted vinylketones enabled by photoredox catalysis has been developed. The current method enables a facile access to highly functionalized cyclohexylamine...

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Yurttas, Leyla, Betul Kaya, Meral Yilmaz Cankilic, and Serkan Levent. "New Cyclohexylamine-dithiocarbamate Derivatives as Potential Anti-microbial Agents." Letters in Drug Design & Discovery 14, no. 11 (2017). http://dx.doi.org/10.2174/1570180814666170412121402.

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"Stereoselective Synthesis of Chiral Cyclohexylamine Derivatives via Photocatalyzed [4+2] Cycloaddition." Synfacts 20, no. 06 (2024): 0607. http://dx.doi.org/10.1055/s-0043-1773249.

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