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Journal articles on the topic 'Cyclomodulin'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Markelova, Natalia N., Elena F. Semenova, Olga N. Sineva, and Vera S. Sadykova. "The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis." International Journal of Molecular Sciences 23, no. 19 (2022): 11706. http://dx.doi.org/10.3390/ijms231911706.

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A number of bacteria that colonize the human body produce toxins and effectors that cause changes in the eukaryotic cell cycle—cyclomodulins and low-molecular-weight compounds such as butyrate, lactic acid, and secondary bile acids. Cyclomodulins and metabolites are necessary for bacteria as adaptation factors—which are influenced by direct selection—to the ecological niches of the host. In the process of establishing two-way communication with the macroorganism, these compounds cause limited damage to the host, despite their ability to disrupt key processes in eukaryotic cells, which can lead

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2

Nouri, Roghayeh, Alka Hasani, Kourosh Masnadi Shirazi, et al. "Mucosa-Associated Escherichia coli in Colorectal Cancer Patients and Control Subjects: Variations in the Prevalence and Attributing Features." Canadian Journal of Infectious Diseases and Medical Microbiology 2021 (November 9, 2021): 1–8. http://dx.doi.org/10.1155/2021/2131787.

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Accumulating evidence indicates that specific strains of mucosa-associated Escherichia coli (E. coli) can influence the development of colorectal carcinoma. This study aimed to investigate the prevalence and characterization of mucosa-associated E. coli obtained from the colorectal cancer (CRC) patients and control group. At two referral university-affiliated hospitals in northwest Iran, 100 patients, 50 with CRC and 50 without, were studied over the course of a year. Fresh biopsy specimens were used to identify mucosa-associated E. coli isolates after dithiothreitol mucolysis. To classify the

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3

Mezerová, Kristýna, Lubomír Starý, Pavel Zbořil, et al. "Cyclomodulins and Hemolysis in E. coli as Potential Low-Cost Non-Invasive Biomarkers for Colorectal Cancer Screening." Life 11, no. 11 (2021): 1165. http://dx.doi.org/10.3390/life11111165.

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The frequent occurrence of E. coli positive for cyclomodulins such as colibactin (CLB), the cytotoxic necrotizing factor (CNF), and the cytolethal distending factor (CDT) in colorectal cancer (CRC) patients published so far provides the opportunity to use them as CRC screening markers. We examined the practicability and performance of a low-cost detection approach that relied on culture followed by simplified DNA extraction and PCR in E. coli isolates recovered from 130 CRC patients and 111 controls. Our results showed a statistically significant association between CRC and the presence of col

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4

Samba-Louaka, Ascel, Jean-Philippe Nougayrède, Claude Watrin, Eric Oswald, and Frédéric Taieb. "The Enteropathogenic Escherichia coli Effector Cif Induces Delayed Apoptosis in Epithelial Cells." Infection and Immunity 77, no. 12 (2009): 5471–77. http://dx.doi.org/10.1128/iai.00860-09.

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ABSTRACT The cycle inhibiting factor (Cif) belongs to a family of bacterial toxins, the cyclomodulins, which modulate the host cell cycle. Upon injection into the host cell by the type III secretion system of enteropathogenic Escherichia coli (EPEC), Cif induces both G2 and G1 cell cycle arrests. The cell cycle arrests correlate with the accumulation of p21waf1 and p27kip1 proteins that inhibit CDK-cyclin complexes, whose activation is required for G1/S and G2/M transitions. Increases of p21 and p27 levels are independent of p53 transcriptional induction and result from protein stabilization t

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5

Hsu, Yun, Gregory Jubelin, Frédéric Taieb, Jean-Philippe Nougayrède, Eric Oswald, and C. Erec Stebbins. "Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli." Journal of Molecular Biology 384, no. 2 (2008): 465–77. http://dx.doi.org/10.1016/j.jmb.2008.09.051.

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6

Canizalez-Roman, Adrian, Juan E. Reina-Reyes, Uriel A. Angulo-Zamudio, et al. "Prevalence of Cyclomodulin-Positive E. coli and Klebsiella spp. Strains in Mexican Patients with Colon Diseases and Antimicrobial Resistance." Pathogens 11, no. 1 (2021): 14. http://dx.doi.org/10.3390/pathogens11010014.

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Colon diseases, such as colorectal cancer (CRC), are multifactor diseases that affect more than one million people per year; recently, the microbiota has been associated with an etiologic factor, specifically bacterial cyclomodulin positivity (CM+). Unfortunately, there are no studies from Mexico that detail the presence of bacterial CM+ in patients with colon diseases. We therefore performed a comprehensive study to investigate the associations and prevalence of cyclomodulin-positive Diarrheagenic E. coli (DEC), non-DEC, and Klebsiella spp. strains isolated from Mexican subjects with colon di

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7

Toro, Tasha B., Julia I. Toth, and Matthew D. Petroski. "The Cyclomodulin Cycle Inhibiting Factor (CIF) Alters Cullin Neddylation Dynamics." Journal of Biological Chemistry 288, no. 21 (2013): 14716–26. http://dx.doi.org/10.1074/jbc.m112.448258.

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8

Buc, Emmanuel, Damien Dubois, Pierre Sauvanet, et al. "High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer." PLoS ONE 8, no. 2 (2013): e56964. http://dx.doi.org/10.1371/journal.pone.0056964.

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9

Chavez, Carolina Varela, Grégory Jubelin, Gabriel Courties, et al. "The cyclomodulin Cif of Photorhabdus luminescens inhibits insect cell proliferation and triggers host cell death by apoptosis." Microbes and Infection 12, no. 14-15 (2010): 1208–18. http://dx.doi.org/10.1016/j.micinf.2010.09.006.

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10

Samba-Louaka, Ascel, Jean-Philippe Nougayrède, Claude Watrin, Grégory Jubelin, Eric Oswald, and Frédéric Taieb. "Bacterial cyclomodulin Cif blocks the host cell cycle by stabilizing the cyclin-dependent kinase inhibitors p21waf1and p27kip1." Cellular Microbiology 10, no. 12 (2008): 2496–508. http://dx.doi.org/10.1111/j.1462-5822.2008.01224.x.

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11

Herrera-Vázquez, Arturo, Rebeca Arellano-Aranda, Daniel Hernández-Cueto, Esmeralda Rodríguez-Miranda, Sergio López-Briones, and Marco Antonio Hernández-Luna. "Detection of Cyclomodulin CNF-1 Toxin-Producing Strains of Escherichia coli in Pig Kidneys at a Slaughterhouse." Microorganisms 11, no. 8 (2023): 2065. http://dx.doi.org/10.3390/microorganisms11082065.

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Food is often contaminated with Escherichia coli (E. coli) bacteria strains, which have been associated with different diseases, including urinary tract infections. The consumption of meat by humans is a potential route of transmission of antimicrobial resistance, and food-producing animals have been associated as a major reservoir of resistant bacterial strains. The aim of this study was to determine the presence of the E. coli strains producing the CNF-1 toxin in pig kidneys. Pig kidneys were collected from a Mexican slaughterhouse and classified according to their coloration into reddish ki

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12

Patel, Hiren G., Seme Tabassum, and Sohail Shaikh. "E. coli Sepsis: Red Flag for Colon Carcinoma—A Case Report and Review of the Literature." Case Reports in Gastrointestinal Medicine 2017 (2017): 1–3. http://dx.doi.org/10.1155/2017/2570524.

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We present an atypical case of newly diagnosed colon cancer and provide insight into the infectious predispositions of E. coli bacteremia to the development of colon adenocarcinoma. A 66-year-old female was admitted to the hospital with one-week symptoms of subjective fevers, chills, and lower back pain. Upon initial evaluation, her temperature was 101 degrees Fahrenheit with a white count of 12,000 K/mm3. Initial septic workup was positive for E. coli bacteremia. The patient was started on Aztreonam. Repeat blood culture 48 hours later was negative for any growth. However, later during hospit

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13

Taieb, Frédéric, Jean-Philippe Nougayrède, Claude Watrin, Ascel Samba-Louaka, and Eric Oswald. "Escherichia coli cyclomodulin Cif induces G2arrest of the host cell cycle without activation of the DNA-damage checkpoint-signalling pathway." Cellular Microbiology 8, no. 12 (2006): 1910–21. http://dx.doi.org/10.1111/j.1462-5822.2006.00757.x.

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14

Putze, Johannes, Claire Hennequin, Jean-Philippe Nougayrède, et al. "Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae." Infection and Immunity 77, no. 11 (2009): 4696–703. http://dx.doi.org/10.1128/iai.00522-09.

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ABSTRACT A genomic island encoding the biosynthesis and secretion pathway of putative hybrid nonribosomal peptide-polyketide colibactin has been recently described in Escherichia coli. Colibactin acts as a cyclomodulin and blocks the eukaryotic cell cycle. The origin and prevalence of the colibactin island among enterobacteria are unknown. We therefore screened 1,565 isolates of different genera and species related to the Enterobacteriaceae by PCR for the presence of this DNA element. The island was detected not only in E. coli but also in Klebsiella pneumoniae, Enterobacter aerogenes, and Cit

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15

Dubois, D., J. Delmas, A. Cady, et al. "Cyclomodulins in Urosepsis Strains of Escherichia coli." Journal of Clinical Microbiology 48, no. 6 (2010): 2122–29. http://dx.doi.org/10.1128/jcm.02365-09.

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16

Nougayrède, Jean-Philippe, Frédéric Taieb, Jean De Rycke, and Eric Oswald. "Cyclomodulins: bacterial effectors that modulate the eukaryotic cell cycle." Trends in Microbiology 13, no. 3 (2005): 103–10. http://dx.doi.org/10.1016/j.tim.2005.01.002.

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17

Taieb, Frédéric, Jean-Philippe Nougayrède, and Eric Oswald. "Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells." Toxins 3, no. 4 (2011): 356–68. http://dx.doi.org/10.3390/toxins3040356.

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18

Amiriani, Taghi, Behnoush Khasheii, Samin Zamanii, Mousa Ghelichi-Ghojogh, and Ailar Jamalli. "Cyclomodulins, Colibactin, and Biofilm-Associated Genes in E. coli from Colorectal Cancer and Precancerous Lesions." Journal of Medical Microbiology and Infectious Diseases 13, no. 1 (2025): 39–49. https://doi.org/10.61186/jommid.13.1.39.

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19

Taieb, Frederic, Domonkos Sváb, Claude Watrin, Eric Oswald, and István Tóth. "Cytolethal distending toxin A, B and C subunit proteins are necessary for the genotoxic effect of Escherichia coli CDT-V." Acta Veterinaria Hungarica 63, no. 1 (2015): 1–10. http://dx.doi.org/10.1556/avet.2015.001.

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Cytolethal distending toxins (CDT) are considered the prototype of inhibitory cyclomodulins, and are produced by a wide range of Gram-negative pathogenic bacteria, includingEscherichia colistrains of various sero- and pathotypes. CDT is a heterotripartite toxin consisting of three protein subunits, CdtA, CdtB and CdtC. The active subunit, CdtB has DNase activity and causes DNA damage and cell cycle arrest in the target cell. However, several studies have highlighted different roles for CdtA and CdtC subunits. In order to reveal the necessity of CdtA and CdtC subunit proteins in the CDT-specifi

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20

Jubelin, Grégory, Carolina Varela Chavez, Frédéric Taieb, et al. "Cycle Inhibiting Factors (CIFs) Are a Growing Family of Functional Cyclomodulins Present in Invertebrate and Mammal Bacterial Pathogens." PLoS ONE 4, no. 3 (2009): e4855. http://dx.doi.org/10.1371/journal.pone.0004855.

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21

Tischenko, Aleksandr, Andrey Koschaev, Aleksandr Valerievich Milovanov, Anastasiya Vasil'evna Elisyutikova, Vladimir Ivanovich Terehov, and Tat'yana Vyacheslavovna Malysheva. "The genetic potential of toxigenic Escherichia coli isolated from calves and piglets." Agrarian Bulletin of the 24, no. 08 (2024): 1071–81. http://dx.doi.org/10.32417/1997-4868-2024-24-08-1071-1081.

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Abstract. The study aims to genetically characterize diarrhoeagenic Escherichia coli isolated from cattle and pigs. The main propose is genetic potential responsible for the production of exotoxins in pathogenic E. coli, the causative agents of escherichiosis in calves and piglets. The scientific novelty of the work consists in deciphering the genomes of diarrheogenic E. coli with the presence of nucleotide sequences of several exotoxins, including thermolabile, thermostable and shigap-like, as well as colicins, hemolysins and cyclomodulins, which have pathogenetic significance in the developm

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22

Shima, Ayaka, Atsushi Hinenoya, Masahiro Asakura, et al. "Molecular Characterizations of Cytolethal Distending Toxin Produced by Providencia alcalifaciens Strains Isolated from Patients with Diarrhea." Infection and Immunity 80, no. 4 (2012): 1323–32. http://dx.doi.org/10.1128/iai.05831-11.

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ABSTRACTCytolethal distending toxins (CDTs), which block eukaryotic cell proliferation by acting as inhibitory cyclomodulins, are produced by diverse groups of Gram-negative bacteria. Active CDT is composed of three polypeptides—CdtA, CdtB, and CdtC—encoded by the genescdtA,cdtB, andcdtC, respectively. We developed a PCR-restriction fragment length polymorphism assay for the detection and differentiation of five alleles ofcdtB(Cdt-I through Cdt-V) inEscherichia coliand used the assay to investigate the prevalence and characteristic of CDT-producingE. coliin children with diarrhea (A. Hinenoya

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23

McCoy, Colleen S., Anthony J. Mannion, Yan Feng, et al. "Cytotoxic Escherichia coli strains encoding colibactin, cytotoxic necrotizing factor, and cytolethal distending toxin colonize laboratory common marmosets (Callithrix jacchus)." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-020-80000-1.

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AbstractCyclomodulins are virulence factors that modulate cellular differentiation, apoptosis, and proliferation. These include colibactin (pks), cytotoxic necrotizing factor (cnf), and cytolethal distending toxin (cdt). Pathogenic pks+, cnf+, and cdt+ E. coli strains are associated with inflammatory bowel disease (IBD) and colorectal cancer in humans and animals. Captive marmosets are frequently afflicted with IBD-like disease, and its association with cyclomodulins is unknown. Cyclomodulin-encoding E. coli rectal isolates were characterized using PCR-based assays in healthy and clinically af

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24

Kamali Dolatabadi, Razie, Hossein Fazeli, Mohammad Hassan Emami, et al. "Phenotypicand Genotypic Characterization of Clinical Isolates of Intracellular Adherent–Invasive Escherichia coli Among Different Stages, Family History, and Treated Colorectal Cancer Patients in Iran." Frontiers in Cellular and Infection Microbiology 12 (July 11, 2022). http://dx.doi.org/10.3389/fcimb.2022.938477.

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There is increasing evidence showing that microbial dysbiosis impacts the health and cancer risk of the host. An association between adherent–invasive Escherichia coli (AIEC) and colorectal cancer (CRC) has been revealed. Cyclomodulins (CMs) have been receiving increasing attention for carcinogenic changes. In this study, the incidence and features of intracellular AIEC and cyclomodulin-encoding genes were investigated and the phylogenetic grouping and genetic relatedness were evaluated. E. coli strains were isolated from the colorectal biopsies. Adhesion and invasion assays and intramacrophag

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25

Hosseininasab, Seyed Abolfazl, Fereshteh Saffari, Omid Tadjrobehkar, et al. "Diffusely Adherent and Cyclomodulin-Positive Escherichia coli Are Associated with Colon Diseases." Jundishapur Journal of Microbiology 17, no. 8 (2024). http://dx.doi.org/10.5812/jjm-147563.

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Background: Any alteration in gut microbiota may result in the colonization of certain pathobionts, leading to the development of colon diseases. Some strains of Escherichia coli are pathobionts that can contribute to the initiation or progression of colon diseases through the induction of pro-inflammatory pathways or the production of genotoxins. Objectives: The present study was performed to investigate the association between certain E. coli pathobionts (cyclomodulin-positive and afa-C+ diffusely adherent E. coli) and their characteristics with colon diseases. Methods: Stool specimens were

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26

Mambu, Julien, Emilie Barilleau, Laetitia Fragnet-Trapp, et al. "Rck of Salmonella Typhimurium Delays the Host Cell Cycle to Facilitate Bacterial Invasion." Frontiers in Cellular and Infection Microbiology 10 (November 2, 2020). http://dx.doi.org/10.3389/fcimb.2020.586934.

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Salmonella Typhimurium expresses on its outer membrane the protein Rck which interacts with the epidermal growth factor receptor (EGFR) of the plasma membrane of the targeted host cells. This interaction activates signaling pathways, leading to the internalization of Salmonella. Since EGFR plays a key role in cell proliferation, we sought to determine the influence of Rck mediated infection on the host cell cycle. By analyzing the DNA content of uninfected and infected cells using flow cytometry, we showed that the Rck-mediated infection induced a delay in the S-phase (DNA replication phase) o

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27

Zhang, Zhen, Kyaw Min Aung, Bernt Eric Uhlin, and Sun Nyunt Wai. "Reversible senescence of human colon cancer cells after blockage of mitosis/cytokinesis caused by the CNF1 cyclomodulin from Escherichia coli." Scientific Reports 8, no. 1 (2018). http://dx.doi.org/10.1038/s41598-018-36036-5.

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28

Morgan, Radwa N., Sarra E. Saleh, Hala A. Farrag, and Mohammad M. Aboulwafa. "Bacterial cyclomodulins: types and roles in carcinogenesis." Critical Reviews in Microbiology, July 15, 2021, 1–25. http://dx.doi.org/10.1080/1040841x.2021.1944052.

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29

El-Aouar Filho, Rachid A., Aurélie Nicolas, Thiago L. De Paula Castro, et al. "Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections." Frontiers in Cellular and Infection Microbiology 7 (May 23, 2017). http://dx.doi.org/10.3389/fcimb.2017.00208.

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30

DeLira-Bustillos, Nora, Uriel A. Angulo-Zamudio, Nidia Leon-Sicairos, et al. "Cyclomodulins-harboring Escherichia coli isolated from obese and normal-weight subjects induces intestinal dysplasia in a mouse model." World Journal of Microbiology and Biotechnology 40, no. 12 (2024). http://dx.doi.org/10.1007/s11274-024-04176-8.

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31

DeLira-Bustillos, Nora, Uriel A. Angulo-Zamudio, Nidia Leon-Sicairos, et al. "Distribution and virulence of Escherichia coli harboring cyclomodulins and supplementary virulence genes isolates from clinical and environmental samples." Microbial Pathogenesis, March 2024, 106634. http://dx.doi.org/10.1016/j.micpath.2024.106634.

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32

El-Aouar Filho, Rachid A., Aurélie Nicolas, Thiago L. De Paula Castro, et al. "Corrigendum: Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections." Frontiers in Cellular and Infection Microbiology 7 (August 14, 2017). http://dx.doi.org/10.3389/fcimb.2017.00364.

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