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Relevant bibliographies by topics / Cyclooxygenase-2 (COX-2) Inhibitors / Dissertations / Theses

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Dissertations / Theses on the topic 'Cyclooxygenase-2 (COX-2) Inhibitors'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Kim, Janet Heejung. "Cyclooxygenase-2 Expression in Post-Mastectomy Chest Wall Relapse." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-104942/.

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The purpose of this study was to assess the prognostic significance and clinical correlations of cyclooxgenase-2 expression (COX) in a cohort of patients treated with radiation (RT) for post-mastectomy chest wall relapse (PMCWR). Between 1975 and 1999, 113 patients were treated for isolated PMCWR. All patients were treated with biopsy and/or excision of the CWR followed by RT. Median follow-up was 10 years. All clinical data including demographics, pathology, staging, receptor status, HER-2/neu status, and adjuvant therapy were entered into a computerized database. Paraffin-embedded CWR specim

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2

Bühler, Nico Martin. "Selektive COX-2 Inhibitoren und Nierenschädigung bei salzsensitiver Hypertonie /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000297941.

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3

Fürstenberg, Antje. "Einfluß des Cyclooxygenase-2-Inhibitors NS-398 auf Proliferation und Apoptose von Ovarialkarzinomzellinien." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15175.

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Mehrere Studien haben gezeigt, daß die Cyclooxygenase-2 (COX-2) eine bedeutende Rolle sowohl bei Entstehung als auch Progression maligner Tumoren spielt. COX-2-Inhibitoren werden bereits in klinischen Studien zur Krebstherapie getestet. COX-2 ist die induzierbare Isoform der Cyclooxygenase - dem Schlüsselenzym der Synthese von Prostaglandinen und anderen Eicosanoiden. Im Tier- und Zellkulturmodell konnten COX-Hemmer anti-Tumor-Effekte hervorrufen. Es ist jedoch unklar, ob diese Effekte durch Hemmung des COX-Enzyms oder durch COX-unabhängige Mechanismen vermittelt werden. Wir untersuchten

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4

Mehar, Ayaz. "Inhibitors of cyclooxygenase-2 (COX-2) and prostate cancer : effects on apoptosis and role in tumour inhibition." Thesis, University of Surrey, 2005. http://epubs.surrey.ac.uk/843556/.

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In comparison to other cancers, advanced prostate cancer is resistant to chemotherapy. There is a need to understand the mechanisms which are responsible for this resistance and find better treatments for this disease or methods to increase the efficacy of current treatments. Cancer cells often evade apoptosis. Cyclooxygenase-2 (COX-2) is an enzyme reported to be elevated in prostate cancer, and has oncogenic properties, including apoptosis attenuation. Because of this, COX-2 inhibition could be beneficial for both prevention and treatment of cancer. This study showed that COX-2 protein was no

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5

Gu, Baoying. "Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy : effects of nimesulide." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112627.

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Wernicke's encephalopathy is a neuropsychiatric disorder resulting from thiamine deficiency (TD) and is characterized by neuronal loss, astrocytic proliferation and microglial activation. Cyclooxygenases (COX) are enzymes which catalyze the first step in the synthesis of prostanoids. COX-1 is expressed constitutively and COX-2 is the inducible isoform. Groups of TD rats and pair-fed controls were killed at presymptomatic and symptomatic stages of encephalopathy. Cresyl violet and NeuN staining showed decreased numbers of neuronal cells in vulnerable regions (medial thalamus and inferior collic

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6

Sawdy, Robert John. "The role of the type-2 isoform of the cyclooxygenase enzyme (COX-2) in human parturition : potential benefits of selective COX-2 inhibitors in the management of preterm labour." Thesis, Imperial College London, 2003. http://hdl.handle.net/10044/1/11444.

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7

Davies, Richard. "Effect of selective COX-2 inhibitors on hepatic progenitor cells and the pathologies of experimental hepatocarcinogenesis." University of Western Australia. School of Medicine and Pharmacology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0190.

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[Truncated abstract] Hepatocellular carcinoma (HCC) is the major malignancy complicating chronic liver disease. New therapies for the prevention of HCC are required due to the limited success and high tumour recurrence rates of existing treatments. Emerging evidence suggests that HCC arise from the transformation of adult liver progenitor cells (LPCs), which have the capacity to differentiate into hepatocytes and biliary cells during liver regeneration. LPC activation precedes neoplasia in experimental hepatocarcinogenesis. LPCs share antigenic epitopes with HCCs, including α-fetoprotein (AFP)

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8

Mukherjee, Kamalika. "ROLE OF CYCLOOXYGENASE-2 IN ABDOMINAL AORTIC ANEURYSMS IN MICE." UKnowledge, 2012. http://uknowledge.uky.edu/pharmacy_etds/29.

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Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease with no available pharmacological treatment. AAA formation reduces the structural integrity of the vessel and increases the susceptibility to rupture. The inflammatory response within human aneurysmal tissue is characterized by increased expression of cyclooxygenase-2 (COX-2). Similarly, in a mouse model of the disease induced by chronic Angiotensin II (AngII) infusion, we have shown that COX-2 expression in the abdominal aortic smooth muscle layer increases early in the development of the disease. Furthermore, genetic or pharma

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9

Valkealahti, M. (Maarit). "The effects of bisphosphonates and COX-2 inhibitors on the bone remodelling unit." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514288548.

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Abstract Bone remodelling occurs in humans throughout life, therefore bone is continuously renewed to better respond to changes in weightbearing circumstances. Bone remodelling is extremely vulnerable during fracture healing and integration of prostheses into the surrounding bone. Bone remodelling is a complex system in which many growth factors, cytokines and enzymes, which are essential for the differentiation of osteoblasts and osteoclasts, are involved. Some widely used drugs can affect this sensitive system of remodellation in unexpected manner. Painkillers such as cyclooxygenase (COX) in

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10

Laube, Markus. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-160091.

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Eine erhöhte COX-2-Expression wird bei Krankheiten wie rheumatoider Arthritis aber auch Parkinson, Alzheimer und Krebs beobachtet. Die nichtinvasive Visualisierung und Quantifizierung der COX 2-Expression in vivo mittels Positronen-Emissions-Tomographie (PET) könnte wertvolle Beiträge zur Diagnose dieser Krankheiten liefern. Zur Nutzung der PET-Technik werden geeignete COX-2-adressierende Radiotracer benötigt, deren Entwicklung auch die Identifizierung neuer, der Radiomarkierung zugänglicher COX-2-Inhibitoren als Leitstrukturen voraussetzt. Ziel dieser Arbeit war die Synthese von selektiven,

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Laube, Markus. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET." Doctoral thesis, Technische Universität Dresden, 2014. https://tud.qucosa.de/id/qucosa%3A28510.

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Eine erhöhte COX-2-Expression wird bei Krankheiten wie rheumatoider Arthritis aber auch Parkinson, Alzheimer und Krebs beobachtet. Die nichtinvasive Visualisierung und Quantifizierung der COX 2-Expression in vivo mittels Positronen-Emissions-Tomographie (PET) könnte wertvolle Beiträge zur Diagnose dieser Krankheiten liefern. Zur Nutzung der PET-Technik werden geeignete COX-2-adressierende Radiotracer benötigt, deren Entwicklung auch die Identifizierung neuer, der Radiomarkierung zugänglicher COX-2-Inhibitoren als Leitstrukturen voraussetzt. Ziel dieser Arbeit war die Synthese von selektiven,

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12

Hoxha, M. "THE POTENTIAL THERAPEUTIC ROLE OF MONTELUKAST AND NEW HYBRID AGENTS, TXA2 ANTAGONIST-COX-2 INHIBITORS IN CARDIOVASCULAR EVENTS." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/347148.

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The main target of my PhD research project was to explore new alternatives to reduce the cardiovascular (CV) risk targeting the arachidonic acid metabolites. Hence, I have been part of two different projects, one studying multitarget compounds with balanced COXIB and TP receptor antagonist properties, and the other evaluating the potential role of a leukotriene (LT) antagonist drug such as montelukast in improving the CV outcome. In reference to the first project, new multitarget compounds were synthesized at the University of Turin, by substituting the carboxylic function of Lumiracoxib.

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13

Mouawad, Charbel. "Effets pleiotropiques des statines : un rôle anti-inflammatoire impliquant la HO-1 et antifibrogénique impliquant la COX-2." Paris 7, 2009. http://www.theses.fr/2009PA077156.

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Les statines sont des inhibiteurs compétitifs de la HMG-CoA réductase, enzyme essentielle dans la voie du mévalonate aboutissant à la biosynthèse du cholestérol. Elles possèdent des propriétés anti-inflammatoires, antiprolifératives, anti-oxydantes et anti-thrombotiques leur conférant un puissant effet protecteur. Les hème-oxygénases sont les enzymes responsables du catabolisme de Thème pour libérer la Fe²⁺, la bilirubine et le monoxyde de carbone. Les deux derniers produits sont responsables des propriétés protectrices. Une large variété de stimuli est capable d'induire l'expression de la hèm

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14

Laube, Markus [Verfasser], Torsten Akademischer Betreuer] Kniess, Jens [Akademischer Betreuer] [Pietzsch, Jörg Akademischer Betreuer] Steinbach, and Thomas [Akademischer Betreuer] [Henle. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET / Markus Laube. Gutachter: Jörg Steinbach ; Thomas Henle. Betreuer: Torsten Kniess ; Jens Pietzsch ; Jörg Steinbach." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://d-nb.info/1069093106/34.

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15

Laube, Markus Verfasser], Torsten [Akademischer Betreuer] Kniess, Jens [Akademischer Betreuer] [Pietzsch, Jörg Akademischer Betreuer] Steinbach, and Thomas [Akademischer Betreuer] [Henle. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET / Markus Laube. Gutachter: Jörg Steinbach ; Thomas Henle. Betreuer: Torsten Kniess ; Jens Pietzsch ; Jörg Steinbach." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://d-nb.info/1069093106/34.

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16

Ping, Peng Jyh, and 彭治平. "Expression of cyclooxygenase-2(COX-2) in hypopharyngeal cancer and modulation of apoptosis and cell cycle progression by COX-2- specific inhibitors." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/37189137185833560059.

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碩士<br>長庚大學<br>臨床醫學研究所<br>91<br>Recent studies demonstrate that cyclooxygenase-2(COX-2) plays a crucial role in tumorigenesis of human cancers. Hypopharyngeal cancer is one of head and neck cancers with very poor prognosis in Taiwan. Betel nut chewing is the major contributory factor of hypopharyngeal cancer. The aim of this study was investigated the expression of COX-2 in primary tumor tissues of hypopharyngeal cancer and examined the effect of betel nut ingredient on COX-2 expression in normal hypopharyngeal and cancer cells. In addition, we addressed the effect of COX-2-specific inhibitor o

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17

Lin, Chih-Lung, and 林志龍. "3D-QSAR study and Virtual Screening on Cyclooxygenase-2 inhibitors with no COX-1 inhibition." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/61846229203832249867.

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碩士<br>國立彰化師範大學<br>生物技術研究所<br>97<br>Cyclooxygenase (COX) that catalyzes the biosynthesis of prostaglandins can be divided into two types: COX-1 (housekeeping enzyme) and COX-2 (indusible enzyme); the existence of them with high amino acid sequence homology and structural similarity but differential expression profiles. COX-2 which is overexpression is often found in inflammatory tissues. In organism, inflammation is an important defense mechanism against pathogens; but it allows autoimmune attack when it was induced abnormally. Nonsteroidal anti-inflammatory drugs (NSAID) such as aspirin are of

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18

"The effect of a selective COX-2 inhibitor, celecoxib, on the proliferation, apoptosis and differential protein expression in nasopharyngeal carcinoma cell lines." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074609.

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Celecoxib is a COX-2 selective non-steroidal anti-inflammatory drug which has been shown to inhibit growth and induce apoptosis in various cancer cell lines. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and an apoptosis detection kit, we demonstrated that celecoxib was able to induce growth inhibition and apoptosis in a dose-dependent manner in 3 NPC cell lines: HK-1, Hone-1, and C666-1. Afterwards, a proteomic approach was used to study the underlying mechanisms involved in celecoxib-mediated effects on two COX-2 positive NPC cell lines (HK-1 and C666-1). Results s

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19

"The impact of selective COX-2 inhibitor on the cost of NSAID-induced gastrointestinal toxicity in a public hospital setting in Hong Kong." 2005. http://library.cuhk.edu.hk/record=b5892477.

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Ho Toi Sze Joyce.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 65-74).<br>Abstracts in English and Chinese.<br>Acknowledgement --- p.ii<br>Contents --- p.iii<br>Abstract --- p.viii<br>List of Abbreviations --- p.xvii<br>List of Tables --- p.xix<br>List of Figures --- p.xx<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- The role of Non-steroidal anti-inflammatory drugs (NSAIDs) --- p.1<br>Chapter 1.2 --- NSAID-induced gastrointestinal (GI) toxicity --- p.1<br>Chapter 1.2.1 --- Pathogenesis of NSAID-induced G

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20

Shen, Yi, and 沈伊. "Synthesis of benzimidazole analogues as cyclooxygenase-2 (COX-2) inhibitor for anticancer agents." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/bk9dtz.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>102<br>The incidence and mortality rates of cancer have become a global health problem. The scientists are striving to better understand cancer biology in an attempt to develop effective strategies for cancer treatment. The occurrence of cancer is closely associated with chronic inflammation, and inflammation-related Cyclooxygenase-2 (COX-2) is also overexpressed in many tumors. COX-2 is thought to be important to various important mechanisms of carcinogenesis including angiogenesis, apoptosis, cell proliferation, tumor invasiveness. As a result of our continuing

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Roy, Shubhendu Sen. "The Phenomenon Of Blastocyst Hatching : Role Of COX-2 And NF-kB." Thesis, 2011. https://etd.iisc.ac.in/handle/2005/2415.

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The zona-pellucida (zona, ZP) is an adhesion-refractory, acellular coat enclosing the rapidly growing, free-living mammalian preimplantation embryo which undergoes successive cleavage divisions to form the blastocyst, composed of ICM-cells surrounded by outer TE-cells. For further development, the blastocyst must ‘hatch’ or ‘escape’ out of the zona before it can implant into the endometrium for further development (Fig. 5.1A). Hence, the event of hatching or ‘zona escape’ assumes critical importance for the establishment of a successful pregnancy. The golden-hamster blastocyst offers a very un

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Roy, Shubhendu Sen. "The Phenomenon Of Blastocyst Hatching : Role Of COX-2 And NF-kB." Thesis, 2011. http://etd.iisc.ernet.in/handle/2005/2415.

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The zona-pellucida (zona, ZP) is an adhesion-refractory, acellular coat enclosing the rapidly growing, free-living mammalian preimplantation embryo which undergoes successive cleavage divisions to form the blastocyst, composed of ICM-cells surrounded by outer TE-cells. For further development, the blastocyst must ‘hatch’ or ‘escape’ out of the zona before it can implant into the endometrium for further development (Fig. 5.1A). Hence, the event of hatching or ‘zona escape’ assumes critical importance for the establishment of a successful pregnancy. The golden-hamster blastocyst offers a very un

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