Relevant bibliographies by topics / Cyclooxygenase (COX)

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Cyclooxygenase (COX)'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Cyclooxygenase (COX)"

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Zhang, Xinping, Scott G. Morham, Robert Langenbach, and Donald A. Young. "Malignant Transformation and Antineoplastic Actions of Nonsteroidal Antiinflammatory Drugs (Nsaids) on Cyclooxygenase-Null Embryo Fibroblasts." Journal of Experimental Medicine 190, no. 4 (1999): 451–60. http://dx.doi.org/10.1084/jem.190.4.451.

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In this study, we use primary embryonic fibroblasts derived from cyclooxygenase-deficient transgenic embryos to further investigate the role of the two cyclooxygenases, cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), in the process of neoplastic transformation. Cells with either, neither, or both of the cyclooxygenases were transformed by Ha-ras and/or SV40. Our results show that when a cyclooxygenase enzyme is present, the transformed cells have marked increases in COX-2 and/or COX-1 expression. Nevertheless, each type of cell, deficient in either or both cyclooxygenases, can be readil
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Rodler, D., and Fred Sinowatz. "Expression of Prostaglandin-Synthesizing Enzymes (Cyclooxygenase 1, Cyclooxygenase 2) in the Ovary of the Quail (Coturnix japonica)." Folia Biologica 61, no. 4 (2015): 125–33. http://dx.doi.org/10.14712/fb2015061040125.

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Cyclooxygenase is known to be the ratelimiting enzyme in the production of prostaglandins. So far, in different bird species there have been found two isoforms of cyclooxygenases (COX), cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2). These isoforms along with prostaglandins are regarded to possess a determining influence on the success in female reproduction. Only in a few bird species the expression sites of cyclooxygenases have been investigated. In this study we report on the expression of COX-1 and COX-2 in the ovary of the quail (Coturnix japonica) using PCR, immunohistochemistry a
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Kutil, Zsofia, Veronika Temml, David Maghradze, et al. "Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity." Mediators of Inflammation 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/178931.

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Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis. Red wines from Georgia and central and western Europe inhibited cyclooxygenase-1 (COX-1) activity in the range of 63–94%, cyclooxygenase-2 (COX-2) activity in the range of 20–44% (tested at a concentration of 5 mL/L), and 5-lipoxygenase (5-LOX) activity in the range of 72–84% (at a concentration of 18.87 mL/L). White wines inhibited 5-LOX in the range of 41–68% at a concentration of 18.87 mL/L and did not inhibit
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Reitz, David B., and Peter C. Isakson. "Cyclooxygenase-2 Inhibitors." Current Pharmaceutical Design 1, no. 2 (1995): 211–20. http://dx.doi.org/10.2174/1381612801666220917221427.

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Prostaglandins are synthesized by the enzyme cyclooxygenase (COX), which is the target for nonsteroidal anti-inflammatory drugs (NSAIDs). Recently a second form of COX was discovered (COX-2) that is induced by inflammatory stimuli. The identification of an inducible form of COX led to the hypothesis that COX-2 is responsible for inflammatory prostaglandins, whereas the constitutive COX-I produces physiologically important prostaglandins, e.g., in stomach and kidney. Selective COX- 2 inhibitors have been shown to be anti-inflammatory but do not cause ulcers in the stomach or intestines. It is a
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Chandrakirana Krisnamurti, Gabriella, and Fatchiyah Fatchiyah. "The Biological Function Prediction of The 10-gingerol Compound of Ginger in Inhibiting Cyclooxygenase-2 Activity." Journal of Pure and Applied Chemistry Research 9, no. 3 (2020): 222–32. http://dx.doi.org/10.21776/ub.jpacr.2020.009.03.547.

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Anti-inflammatory agents inhibit prostaglandin synthesis by blocking cyclooxygenases (COXs). The compounds extracted from ginger, 10-gingerol and 10-shogaol can inhibit inflammation but the mechanism of inhibition remains unclear. Here we used molecular docking to predict the molecular interactions between COXs and the three inhibitors, acetaminophen (CID1983), 10-gingerol (CID168115) and 10-shogaol (CID6442612). By using that acetaminophen as a gold standard, the results demonstrated that acetaminophen, 10-gingerol, and 10-shogaol could bind catalytic domain and membrane binding domain of cyc
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Belton, Orina, and Desmond J. Fitzgerald. "Cyclooxygenase isoforms and atherosclerosis." Expert Reviews in Molecular Medicine 5, no. 9 (2003): 1–18. http://dx.doi.org/10.1017/s1462399403005842.

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of arthritis and pain. However, their long-term use is limited by gastrointestinal (GI) side effects such as gastric ulcers. NSAIDs act by inhibiting an enzyme called cyclooxygenase. Cyclooxygenase (COX) catalyses the generation of prostaglandins from arachidonic acid. Two isoforms of the enzyme exist – COX-1 and COX-2 – both of which are targets for NSAIDs. Although they are associated with GI toxicity, NSAIDs have important antithrombotic and anti-inflammatory effects. The GI injury has been attributed to COX-1 in
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Brannon, Timothy S., Amy N. MacRitchie, Marina A. Jaramillo, et al. "Ontogeny of cyclooxygenase-1 and cyclooxygenase-2 gene expression in ovine lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 274, no. 1 (1998): L66—L71. http://dx.doi.org/10.1152/ajplung.1998.274.1.l66.

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Prostacyclin is a key mediator of pulmonary vascular and parenchymal function during late fetal and early postnatal life, and its synthesis in whole lung increases during that period. The rate-limiting enzyme in prostacyclin synthesis in the developing lung is cyclooxygenase (COX). We investigated the ontogeny and cellular localization of COX-1 (constitutive) and COX-2 (inducible) gene expression in lungs from late-gestation fetal lambs, 1-wk-old newborn lambs (NB1), and 1- to 4-mo-old newborn lambs (NB2). COX-1 mRNA abundance rose progressively from fetal to NB1 to NB2, increasing 12-fold ove
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Odau, Simone, Christoph Gabler, Christoph Holder, and Ralf Einspanier. "Differential expression of cyclooxygenase 1 and cyclooxygenase 2 in the bovine oviduct." Journal of Endocrinology 191, no. 1 (2006): 263–74. http://dx.doi.org/10.1677/joe.1.06761.

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The aim of the present study was to investigate the enzymes for the local prostaglandin (PG) biosynthesis present in the bovine oviduct during the estrous cycle to influence early reproductive events. Bovine oviducts were classified into four phases: pre-ovulatory, post-ovulatory, early-to-mid luteal, and late luteal phase, subdivided further into ipsi- or contralateral site and separated into ampulla or isthmus. Oviductal cells were gained by flushing the oviductal regions. Quantitative real-time reverse transcriptase-PCR was performed for the secretory and cytosolic phospholipases A2 (sPLA2I
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Hofer, Michal, and Milan Pospíšil. "Stimulated recovery of perturbed haematopoiesis by inhibition of prostaglandin production — promising therapeutic strategy." Open Life Sciences 1, no. 4 (2006): 584–93. http://dx.doi.org/10.2478/s11535-006-0033-3.

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AbstractInhibitors of prostaglandin production, designated as classical non-steroidal anti-inflammatory drugs (NSAIDs) and acting on the base of non-selective inhibition of cyclooxygenases, have been found in numerous studies to potentiate recovery of perturbed haematopoiesis by removing the negative feedback control mediated by prostaglandins. However, classical NSAIDs show pronounced undesirable gastrointestinal side effects, which limits the possibility of their utilization for various pathophysiological states including myelosuppression. Specific cyclooxygenase-2 (COX-2) inhibitors, target
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Hayes, Maria, Rotimi E. Aluko, Elena Aurino, and Leticia Mora. "Generation of Bioactive Peptides from Porphyridium sp. and Assessment of Their Potential for Use in the Prevention of Hypertension, Inflammation and Pain." Marine Drugs 21, no. 8 (2023): 422. http://dx.doi.org/10.3390/md21080422.

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Inflammation, hypertension, and negative heart health outcomes including cardiovascular disease are closely linked but the mechanisms by which inflammation can cause high blood pressure are not yet fully elucidated. Cyclooxygenase (COX) enzymes play a role in pain, inflammation, and hypertension development, and inhibition of these enzymes is currently of great interest to researchers and pharmaceutical companies. Non-steroidal anti-inflammatory drugs are the drug of choice in terms of COX inhibition but can have negative side effects for consumers. Functional food ingredients containing cyclo
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Dissertations / Theses on the topic "Cyclooxygenase (COX)"

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Sun, Haipeng. "Regulation of Cyclooxygenase Gene Expression by Glucocorticoids in Cardiomyocytes." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194896.

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Glucocorticoids (GCs) are endogenous steroid hormones that regulate a number of critical physiological processes. Psychological stress increases the level of GCs in the circulating system. The biological effect of elevated GCs on the heart is not well understood. We found that GCs induced Cyclooxygenase-1 (COX-1) and COX-2 gene expression in cardiomyocytes. COX-1 or COX-2 encodes the rate-limiting enzyme in the biosynthesis of prostanoids, which modulate crucial physiological and pathophysiological responses. The present studies aim to elucidate the signaling transduction pathway and the
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Tarantino, E. "THE ROLE OF CYCLOOXYGENASE-1 (COX-1) AND CYCLOOXYGENASE-2 (COX-2) IN A VENOUS THROMBOSIS MOUSE MODEL." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/353697.

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Background: Deep vein thrombosis (DVT) is a serious national health problem, and pulmonary thromboembolism (PE) represents the life-threatening most common complication. Venous thromboembolism (VTE), including both these conditions, is traditionally treated with anticoagulant drugs. In particular, vitamin K antagonists and heparins are usually used in the reduction of thrombus development and in secondary prevention. However, the use of these drugs has several limitations: wide variability dose/response relationship between patients and in the same patient, multiple interactions with other dru
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Hunter, John Cameron. "Multiple Recoding Mechanisms Produce Cyclooxygenase and Cyclooxygenase-Related Proteins from Frameshift-Containing COX-3/COX-1b Transcripts in Rat and Human." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/6149.

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To increase diversity of enzymes and proteins, cells mix and match exonic and intronic regions retained in mature mRNAs by alternative splicing. An estimated 94% of all multi-exon genes express one or more alternatively spliced transcripts generating proteins with similar or modified functions. Cyclooxygenase is a signaling enzyme that catalyzes the rate-limiting step in the synthesis of diverse bioactive lipids termed prostaglandins. Prostaglandins are involved in myriad physiological and pathopysiological processes including vasoregulation, stomach mucosal maintenance, parturition, pain, f
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Chen, Suzi Su-Hsin, and suzi chen@med monash edu au. "Cyclooxygenase Expression in Human Diabetes." RMIT University. Medical Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080206.121439.

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Cyclooxygenase (COX) is the rate limiting enzyme that catalyses the production of prostanoids, which are crucial to vascular homeostasis. Evidence suggests that endothelial dysfunction and inflammation play a role in vascular complications in aging and diabetes. Previous animal studies by our laboratory at RMIT University reported enhanced COX expression with aging in rat aortas, platelets and monocytes. Potentially, alteration in COX expression may result in an imbalanced prostanoid production favoring the synthesis of vasoconstrictors and hence increase the risk of cardiovascular events in t
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Bühler, Nico Martin. "Selektive COX-2 Inhibitoren und Nierenschädigung bei salzsensitiver Hypertonie /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000297941.

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Kellogg, Aaron. "Effect of Cyclooxygenase (COX)-2 Activation on Diabetic Neuropathy." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1211909697.

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Kim, Janet Heejung. "Cyclooxygenase-2 Expression in Post-Mastectomy Chest Wall Relapse." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-104942/.

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The purpose of this study was to assess the prognostic significance and clinical correlations of cyclooxgenase-2 expression (COX) in a cohort of patients treated with radiation (RT) for post-mastectomy chest wall relapse (PMCWR). Between 1975 and 1999, 113 patients were treated for isolated PMCWR. All patients were treated with biopsy and/or excision of the CWR followed by RT. Median follow-up was 10 years. All clinical data including demographics, pathology, staging, receptor status, HER-2/neu status, and adjuvant therapy were entered into a computerized database. Paraffin-embedded CWR specim
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Vijitruth, Rattanavijit. "ROLES OF CYCLOOXYGENASE-2 IN MICROGLIAL ACTIVATION AND DOPAMINERGIC CELL DEATH." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/237.

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Accumulating evidence suggests that inflammation plays an important role in the progression ofParkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase(COX), especially the inducible isoform, COX-2, is believed to be the critical enzyme in theinflammatory response. Induction of COX-2 is also found in an experimental model of PD producedby administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To investigate whetherinhibition of COX-2 by valdecoxib or deficiency in COX-2 could prevent dopaminergic neuronaltoxicity and locomotor activity impai
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Mukherjee, Kamalika. "ROLE OF CYCLOOXYGENASE-2 IN ABDOMINAL AORTIC ANEURYSMS IN MICE." UKnowledge, 2012. http://uknowledge.uky.edu/pharmacy_etds/29.

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Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease with no available pharmacological treatment. AAA formation reduces the structural integrity of the vessel and increases the susceptibility to rupture. The inflammatory response within human aneurysmal tissue is characterized by increased expression of cyclooxygenase-2 (COX-2). Similarly, in a mouse model of the disease induced by chronic Angiotensin II (AngII) infusion, we have shown that COX-2 expression in the abdominal aortic smooth muscle layer increases early in the development of the disease. Furthermore, genetic or pharma
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Kim, Youngsoo. "Molecular characterization of cyclooxygenase-2 (COX-2) expression in murine skin carcinoma cells /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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Books on the topic "Cyclooxygenase (COX)"

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Masline, Shelagh Ryan. Celebrex: Cox-2 inhibitors--the amazing new pain fighters. Avon Books, 1999.

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R, Vane John, Botting Regina M, William Harvey Research Conference (1997 : Phuket, Thailand), and William Harvey Research Conference (1998 : Boston, Mass.), eds. Clinical significance and potential of selective COX-2 inhibitors: The combined proceedings of the William Harvey Conferences held in Phuket, Thailand, on 18-19 September, 1997 and in Boston, USA, on 23-24 April, 1998, supported by an educational grant from Boehringer Ingelheim. William Harvey Press, 1998.

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E, Harris Randall, ed. Inflammation in the pathogenesis of chronic diseases: The COX-2 controversy. Springer, 2007.

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G, Bazán Nicolás, Botting Jack H, and Vane John R, eds. New targets in inflammation: Inhibitors of COX-2 or adhesion molecules : proceedings of a conference held on April 15-16, 1996, in New Orleans, USA, supported by an educational grant from Boehringer Ingelheim. Kluwer Academic Publishers, 1996.

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Barragry, Thomas B. N.S.A.I.D.S./toxicity: COX 2 developments. [University College Dublin, Department of Small Animal Studies], 1998.

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Vane, John R. Improved non-steroid anti-flammatory drugs COX-2 enzyme inhibitors: Proceedings of a conference held on October 10-11, 1995, at Regent's College, London. Kluwer Academic Publishers, 1996.

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William Harvey Conference (1995 London, England). Improved non-steroid anti-inflammatory drugs: COX-2 enzyme inhibitors : proceedings of a conference held on October 10-11, 1995, at Regent's College, London. Kluwer Academic, 1996.

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Vane, Sir John, ed. Clinical Significance And Potential Of Selective Cox-2 Inhibitors. WILLIAM HARVEY PRESS, 1998.

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Sir John R. Vane (Editor) and Jack H. Botting (Editor), eds. Selective COX-2 Inhibitors: Pharmacology, Clinical Effects and Therapeutic Potential. Springer, 1998.

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Botting, Jack H., and Sir John R. Vane. Selective COX-2 Inhibitors: Pharmacology, Clinical Effects and Therapeutic Potential. Springer, 2012.

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Book chapters on the topic "Cyclooxygenase (COX)"

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F�rstenberger, G., F. Marks, and K. M�ller-Decker. "Cyclooxygenase-2 and Skin Carcinogenesis." In COX-2. KARGER, 2003. http://dx.doi.org/10.1159/000071367.

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DuBois, R. N. "Cyclooxygenase-2 and Colorectal Cancer." In COX-2. KARGER, 2003. http://dx.doi.org/10.1159/000071370.

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Dubinett, S. M., S. Sharma, M. Huang, M. Dohadwala, M. Pold, and J. T. Mao. "Cyclooxygenase-2 in Lung Cancer." In COX-2. KARGER, 2003. http://dx.doi.org/10.1159/000071371.

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Rodger, Ian W., and Chi-Chung Chan. "Inducible Cyclooxygenase (COX-2)." In Neuroinflammation. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-59259-473-3_14.

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Patrono, C., F. Cipollone, G. Renda, and P. Patrignani. "Cyclooxygenase enzymes in human vascular disease." In Selective COX-2 Inhibitors. Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-4872-6_7.

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Saha, D., and H. Choy. "Potential for Combined Modality Therapy of Cyclooxygenase Inhibitors and Radiation." In COX-2. KARGER, 2003. http://dx.doi.org/10.1159/000071374.

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Koki, Alane T., Kathleen M. Leahy, Janet M. Harmon, and Jaime L. Masferrer. "Cyclooxygenase-2 and Cancer." In COX-2 Blockade in Cancer Prevention and Therapy. Humana Press, 2003. https://doi.org/10.1007/978-1-59259-302-6_12.

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Gately, S., and R. Kerbel. "Therapeutic Potential of Selective Cyclooxygenase-2 Inhibitors in the Management of Tumor Angiogenesis." In COX-2. KARGER, 2003. http://dx.doi.org/10.1159/000071373.

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Hsi, Linda C., and Thomas E. Eling. "Carcinogenesis Involving Cyclooxygenase and Lipoxygenase." In COX-2 Blockade in Cancer Prevention and Therapy. Humana Press, 2003. https://doi.org/10.1007/978-1-59259-302-6_15.

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Hawk, E. T., J. L. Viner, and A. Umar. "Non-Steroidal Anti-Inflammatory and Cyclooxygenase-2-Selective Inhibitors in Clinical Cancer Prevention Trials." In COX-2. KARGER, 2003. http://dx.doi.org/10.1159/000071375.

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Conference papers on the topic "Cyclooxygenase (COX)"

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Katanić Stanković, Jelena S., Vanja Todorović, Jelena Đorović Jovanović, et al. "„In vitro“ and „in silico“ assessment of anti-inflammatory activity of cocoa powders." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.156ks.

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Plants are considered the major sources of biologically active compounds, which provide unlimited opportunities for their use either as medical treatments or as novel drug formulations. Cocoa powder is frequently used in nutrition and is known to have many benefits thanks to its wide range of biological activities. The presented study was focused on the evaluation of the anti-inflammatory potential of extracts obtained from cocoa powder. In vitro assays were employed to evaluate the level of inhibition of cyclooxygenases-1 and -2 activities (COX-1 and COX-2) by tested extracts. Molecular docki
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Branković, Jovica, Vesna Milovanović, and Vladimir P. Petrović. "CYCLOOXYGENASE-2 AS „IN SILICO“ TARGET OF PHENOLIC HYDRAZONE- TYPE DERIVATIVES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.324b.

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In the present work, a series of phenolic hydrazone analogs were investigated in silico for their potential inhibitory activity toward COX-2. These examinations were based on the capability of hydrazone-based compounds to interact with numerous enzymes, as well as on their versatile biological features and therapeutical applications. COX-2 was selected due to its involvement in the inflammation and carcinogenesis processes. Regarding this, COX-2 represents a valid target for the development of compounds that could block the formation of harmful inflammation mediators.
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Damayanti, Sophi, Andhika Bintang Mahardhika, Slamet Ibrahim, Wei Lim Chong, Vannajan Sanghiran Lee, and Daryono Hadi Tjahjono. "O-desmethylquinine as a cyclooxygenase-2 (COX-2) inhibitors using AutoDock Vina." In 3RD INTERNATIONAL CONFERENCE ON FUNDAMENTAL AND APPLIED SCIENCES (ICFAS 2014): Innovative Research in Applied Sciences for a Sustainable Future. AIP Publishing LLC, 2014. http://dx.doi.org/10.1063/1.4898452.

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Haase-Kohn, C., C. K. Donat, M. Laube, et al. "Cyclooxygenase-2 (COX-2) and its role in metabolism of U87 glioblastoma." In 61. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1766263.

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Ariza-Rua, Danilo L., Edisson Chavarro-Mesa, Yamil Ballestas-Casallas, Juan Rebollo-Perez, and Wilson Maldonado-Rojas. "Molecular docking studies of 4-nitromonosubstituted chalcone derivatives as cyclooxygenase-2 (COX-2) inhibitors." In 11TH INTERNATIONAL CONFERENCE ON MATHEMATICAL MODELING IN PHYSICAL SCIENCES. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0163262.

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Killian, Megan L., Barbara Zielinska, and Tammy L. Haut Donahue. "Role of IL-1 on Aggrecanase and COX-2 Gene Expression of Meniscal Explants Following Dynamic Compression." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19110.

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The menisci within the knee likely respond to adverse loading conditions, leading to aggravated cartilage damage and fissuring [1]. Upregulation of catabolic molecules such as interleukin-1α (IL-1α), metalloproteinases (MMPs), aggrecanases (ADAMTS-4 and -5), and cyclooxygenase-2 (COX-2), as well as release of proteoglycans [2], have been shown in vitro for meniscal explants following dynamic loading [3]. A crucial event in matrix degradation is the loss of aggrecan, caused by the ADAMTS family [4]. In osteoarthritic cartilage, IL-1 has been shown to influence COX-2 activity, leading to increas
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Veisi, Zeinab, Muhammet Ceylan, Anil Mahapatro, and Ramazan Asmatulu. "An Electrospun Polyaniline Nanofiber as a Novel Platform for Real-Time COX-2 Biomarker Detection." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-65269.

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The presence of Cyclooxygenase-2 (COX-2) biomarker has been associated with the development of certain types of cancer such as breast cancer. Moreover, reliable quantification of COX-2 as an enzyme responsible for pain and inflammation is vital. Here we demonstrate the feasibility of sensitive COX-2 detection via integration of nanoporous polyaniline fibers on the microfabricated platform to develop a label-free biosensor. Highly porous polyaniline nanofibers were fabricated in different diameters and integrated on the interdigitated microelectrodes to develop electrochemical platforms. Charac
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Beteringhe, Adrian, and Flavia Corina Mitroi Symeonidis. "Molecular Docking Technique for selection of some naproxen derivatives as inhibitors of cyclooxygenase 2 (COX-2)." In 2015 7th International Conference on Electronics, Computers and Artificial Intelligence (ECAI). IEEE, 2015. http://dx.doi.org/10.1109/ecai.2015.7301240.

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Premprasert, C., S. Tewtrakul, and J. Wungsintaweekul. "Plaunol A isolated from Croton stellatopilosus suppress inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400145.

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Daham, K., WL Song, A. Gulich, et al. "Prostaglandin (PG) D2Formation in Subjects with Asthma Occurs Via the Cyclooxygenase-1 (COX-1) Pathway at Baseline." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2773.

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Reports on the topic "Cyclooxygenase (COX)"

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กาญจนทัต, อภิชาติ. ความเป็นพิษและการเหนี่ยวนำการตายแบบอะโพโทซิสต่อเซลล์มะเร็ง โดยเพปไทด์จากเกสรผึ้งพันธุ์ Apis mellifera. สถาบันวิจัยเทคโนโลยีชีวภาพและวิศวกรรมพันธุศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2018. https://doi.org/10.58837/chula.res.2018.100.

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งานวิจัยนี้เตรียมโปรตีนไฮโดรไลเสตจากเกสรผึ้งพันธุ์ ที่ได้จากปฏิกิริยาย่อยสลายด้วยเอนไซม์ 3 ชนิด ได้แก่ แอลคาเลส ฟลาโวไซม์ และนิวเทรส พบว่าเมื่อใช้นิวเทรสในอัตราส่วนของเอนไซม์ต่อสับสเตรต 1:1 (NH1) โดยปริมาตร จะให้แสดงค่าการยับยั้งการสร้างอนุมูลอิสระด้วยวิธีไนตริกออกไซต์ได้ดีที่สุด คัดแยกเพปไทด์ที่มีขนาดโมเลกุลต่ำกว่า 0.65 กิโลดาลตัน (MW1) มีฤทธิ์ในการขจัดอนุมูลอิสระไนตริกออกไซด์ได้ดีที่สุด จากนั่นได้ทำการตรวจสอบความเป็นพิษของ MW1 ด้วยวิธี MTT และตรวจสอบ ผลการยับยั้งการสร้างไนตริกออกไซด์ในเซลล์แมคโครฟาจ RAW 264.7 ที่ถูกกระตุ้นด้วยไลโปโพลิแซคคาไรด์ พบว่า MW1 ไม่มีความเป็นพิษต่อเซลล์ และมีฤทธิ์ในก
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Splitter, Gary, Zeev Trainin, and Yacov Brenner. Lymphocyte Response to Genetically Engineered Bovine Leukemia Virus Proteins in Persistently Lymphocytic Cattle from Israel and the U.S. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570556.bard.

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The goal of this proposal was to identify proteins of BLV recognized by lymphocyte subpopulations and determine the contribution of these proteins to viral pathogenesis. Our hypothesis was that BLV pathogenesis is governed by the T-cell response and that the immune system likely plays an important role in controlling the utcome of infection. Our studies presented in ths final report demonstrate that T cell competency declines with advancing stages of infection. Dramatic differences were observed in lymphocyte proliferation to recombinant proteins encoded by BLV gag (p12, p15, and p24) and env
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Pavasant, Prasit, and Tussanee Yongchaitrakul. Influence of mechanical stress on the expression of osteopontin in human periodontal ligament cells. Chulalongkorn University, 2008. https://doi.org/10.58837/chula.res.2008.14.

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Background: Mechanical stress such as orthodontic forces can produce mechanical damage and inflammatory reaction in periodontium. Osteopontin (OPN) is a multifunctional cytokine that found to be correlated with periodontal disease progression. As periodontal ligaments (PDL) can be affected by stress and PDL cells are involved in periodontal destruction and remodeling, we aimed to investigate the influence of mechanical stress on the expression and regulation of OPN in human PDL (HPDL) cells. Methods: The mechanical stress was generated by continuous compressive force and the expression of OPN
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Alwagdani, Abdullah. Review Of mPGES-1 Inhibitors Based On The Benzoxazole And Its Isostere Scaffold For The Treatment Of Inflammatory Diseases. University of Tennessee Health Science Center, 2024. http://dx.doi.org/10.21007/com.lsp.2024.0021.

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The vital role of the prostanoid pathway in inflammation, pain, cancer, Alzheimer’s and many other diseases has attracted the drug discovery community to discover targets for therapeutic development. Although existing non-steroidal anti-inflammatory drugs (NSAIDs) inhibiting cyclooxygenases (COX) are widely used, the side effects of these NSAIDs limit the ling time medication. Microsomal prostaglandin E synthase-1 (mPGES-1) is an attractive target that is overexpressed during inflammations, and it could be a safe alternative to NSAIDs for treating inflammatory diseases.Since the discovery of m
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Fields, Michael J., Mordechai Shemesh, and Anna-Riitta Fuchs. Significance of Oxytocin and Oxytocin Receptors in Bovine Pregnancy. United States Department of Agriculture, 1994. http://dx.doi.org/10.32747/1994.7568790.bard.

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Oxytocin has multiple actions in bovine reproductive tract and it was our purpose to determine the nature of these actions and their significance for the physiology of bovine reproduction. The bovine oxytocin receptors (OTR) gene was cloned and its expression studied during the cycle and pregnancy. OTR mRNA changed in parallel with OTR with control occurring mainly at the transcriptional level. However, the endocrine regulation of OTR were found in endometrium and cervical mucosa at estrus and at parturition. In both tissues OTR were suppressed in the luteal phase and early pregnancy. Whereas
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