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Dissertations / Theses on the topic 'Cyclooxygenase (COX)'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Sun, Haipeng. "Regulation of Cyclooxygenase Gene Expression by Glucocorticoids in Cardiomyocytes." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194896.

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Glucocorticoids (GCs) are endogenous steroid hormones that regulate a number of critical physiological processes. Psychological stress increases the level of GCs in the circulating system. The biological effect of elevated GCs on the heart is not well understood. We found that GCs induced Cyclooxygenase-1 (COX-1) and COX-2 gene expression in cardiomyocytes. COX-1 or COX-2 encodes the rate-limiting enzyme in the biosynthesis of prostanoids, which modulate crucial physiological and pathophysiological responses. The present studies aim to elucidate the signaling transduction pathway and the

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2

Tarantino, E. "THE ROLE OF CYCLOOXYGENASE-1 (COX-1) AND CYCLOOXYGENASE-2 (COX-2) IN A VENOUS THROMBOSIS MOUSE MODEL." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/353697.

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Background: Deep vein thrombosis (DVT) is a serious national health problem, and pulmonary thromboembolism (PE) represents the life-threatening most common complication. Venous thromboembolism (VTE), including both these conditions, is traditionally treated with anticoagulant drugs. In particular, vitamin K antagonists and heparins are usually used in the reduction of thrombus development and in secondary prevention. However, the use of these drugs has several limitations: wide variability dose/response relationship between patients and in the same patient, multiple interactions with other dru

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3

Hunter, John Cameron. "Multiple Recoding Mechanisms Produce Cyclooxygenase and Cyclooxygenase-Related Proteins from Frameshift-Containing COX-3/COX-1b Transcripts in Rat and Human." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/6149.

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To increase diversity of enzymes and proteins, cells mix and match exonic and intronic regions retained in mature mRNAs by alternative splicing. An estimated 94% of all multi-exon genes express one or more alternatively spliced transcripts generating proteins with similar or modified functions. Cyclooxygenase is a signaling enzyme that catalyzes the rate-limiting step in the synthesis of diverse bioactive lipids termed prostaglandins. Prostaglandins are involved in myriad physiological and pathopysiological processes including vasoregulation, stomach mucosal maintenance, parturition, pain, f

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4

Chen, Suzi Su-Hsin, and suzi chen@med monash edu au. "Cyclooxygenase Expression in Human Diabetes." RMIT University. Medical Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080206.121439.

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Cyclooxygenase (COX) is the rate limiting enzyme that catalyses the production of prostanoids, which are crucial to vascular homeostasis. Evidence suggests that endothelial dysfunction and inflammation play a role in vascular complications in aging and diabetes. Previous animal studies by our laboratory at RMIT University reported enhanced COX expression with aging in rat aortas, platelets and monocytes. Potentially, alteration in COX expression may result in an imbalanced prostanoid production favoring the synthesis of vasoconstrictors and hence increase the risk of cardiovascular events in t

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Bühler, Nico Martin. "Selektive COX-2 Inhibitoren und Nierenschädigung bei salzsensitiver Hypertonie /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000297941.

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6

Kellogg, Aaron. "Effect of Cyclooxygenase (COX)-2 Activation on Diabetic Neuropathy." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1211909697.

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7

Kim, Janet Heejung. "Cyclooxygenase-2 Expression in Post-Mastectomy Chest Wall Relapse." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-104942/.

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The purpose of this study was to assess the prognostic significance and clinical correlations of cyclooxgenase-2 expression (COX) in a cohort of patients treated with radiation (RT) for post-mastectomy chest wall relapse (PMCWR). Between 1975 and 1999, 113 patients were treated for isolated PMCWR. All patients were treated with biopsy and/or excision of the CWR followed by RT. Median follow-up was 10 years. All clinical data including demographics, pathology, staging, receptor status, HER-2/neu status, and adjuvant therapy were entered into a computerized database. Paraffin-embedded CWR specim

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8

Vijitruth, Rattanavijit. "ROLES OF CYCLOOXYGENASE-2 IN MICROGLIAL ACTIVATION AND DOPAMINERGIC CELL DEATH." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/237.

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Accumulating evidence suggests that inflammation plays an important role in the progression ofParkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase(COX), especially the inducible isoform, COX-2, is believed to be the critical enzyme in theinflammatory response. Induction of COX-2 is also found in an experimental model of PD producedby administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To investigate whetherinhibition of COX-2 by valdecoxib or deficiency in COX-2 could prevent dopaminergic neuronaltoxicity and locomotor activity impai

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9

Mukherjee, Kamalika. "ROLE OF CYCLOOXYGENASE-2 IN ABDOMINAL AORTIC ANEURYSMS IN MICE." UKnowledge, 2012. http://uknowledge.uky.edu/pharmacy_etds/29.

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Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease with no available pharmacological treatment. AAA formation reduces the structural integrity of the vessel and increases the susceptibility to rupture. The inflammatory response within human aneurysmal tissue is characterized by increased expression of cyclooxygenase-2 (COX-2). Similarly, in a mouse model of the disease induced by chronic Angiotensin II (AngII) infusion, we have shown that COX-2 expression in the abdominal aortic smooth muscle layer increases early in the development of the disease. Furthermore, genetic or pharma

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10

Kim, Youngsoo. "Molecular characterization of cyclooxygenase-2 (COX-2) expression in murine skin carcinoma cells /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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11

Huang, Hai. "The role of cyclooxygenase gene in liver inflammation using COX-1 knockout mice /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36396539.

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12

Strillacci, Antonio <1979&gt. "RNA Interference and cyclooxygenase-2 (COX-2) regulation in colon cancer cells." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/680/1/Tesi_Strillacci_Antonio.pdf.

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Despite new methods and combined strategies, conventional cancer chemotherapy still lacks specificity and induces drug resistance. Gene therapy can offer the potential to obtain the success in the clinical treatment of cancer and this can be achieved by replacing mutated tumour suppressor genes, inhibiting gene transcription, introducing new genes encoding for therapeutic products, or specifically silencing any given target gene. Concerning gene silencing, attention has recently shifted onto the RNA interference (RNAi) phenomenon. Gene silencing mediated by RNAi machinery is based on sho

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13

Strillacci, Antonio <1979&gt. "RNA Interference and cyclooxygenase-2 (COX-2) regulation in colon cancer cells." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/680/.

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Despite new methods and combined strategies, conventional cancer chemotherapy still lacks specificity and induces drug resistance. Gene therapy can offer the potential to obtain the success in the clinical treatment of cancer and this can be achieved by replacing mutated tumour suppressor genes, inhibiting gene transcription, introducing new genes encoding for therapeutic products, or specifically silencing any given target gene. Concerning gene silencing, attention has recently shifted onto the RNA interference (RNAi) phenomenon. Gene silencing mediated by RNAi machinery is based on sho

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14

Huang, Hai, and 黃海. "The role of cyclooxygenase gene in liver inflammation using COX-1 knockout mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010699.

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15

Hurst, Emma Allan. "Identification and characterisation of the role of cyclooxygenase-2 (COX-2) in cancer stem cell biology : a comparative study." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28852.

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Cancer is a stem cell disease and populations of cancer stem cells (CSCs) are evident in many cancer types. CSCs exhibit similarities to normal embryonic and adult stem cells: they are able to self-renew and have the potential to give rise to a diverse array of differentiated progeny. CSCs are responsible for driving tumourigenesis and metastasis, and are inherently resistant to chemotherapy and radiotherapy. This cell population is enriched after treatment and, as a result of their tumourigenic capability, can re-populate tumour growth resulting in patient relapse, often with increased chemot

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16

Fürstenberg, Antje. "Einfluß des Cyclooxygenase-2-Inhibitors NS-398 auf Proliferation und Apoptose von Ovarialkarzinomzellinien." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15175.

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Mehrere Studien haben gezeigt, daß die Cyclooxygenase-2 (COX-2) eine bedeutende Rolle sowohl bei Entstehung als auch Progression maligner Tumoren spielt. COX-2-Inhibitoren werden bereits in klinischen Studien zur Krebstherapie getestet. COX-2 ist die induzierbare Isoform der Cyclooxygenase - dem Schlüsselenzym der Synthese von Prostaglandinen und anderen Eicosanoiden. Im Tier- und Zellkulturmodell konnten COX-Hemmer anti-Tumor-Effekte hervorrufen. Es ist jedoch unklar, ob diese Effekte durch Hemmung des COX-Enzyms oder durch COX-unabhängige Mechanismen vermittelt werden. Wir untersuchten

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17

Wang, Xingya. "The distinct role of cyclooxygenase-2 in prostate and bladder carcinogenesis." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180488733.

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18

Fredericks, Ernst. "Molecular signaling in colorectal carcinogenesis : the roles and relationships of beta-catenin, PPARgamma and COX-2." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1021014.

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Colorectal cancer (CRC) is a common disease with significant morbidity and mortality. In spite of significant advances in understanding the molecular signaling in this disorder, unanswered questions remain. Cyclooxygenase-2 (COX-2) and β-catenin have established roles in colorectal carcinogenesis, with both being upregulated early in the disease course. The role of peroxisome proliferator-activated receptor γ (PPARγ) is less clear, but has been shown to be downregulated in colon cancer models. Butyrate, a short chain fatty acid, produced by colon microbiota and transported into the colonocyte

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19

Abdalla, Salem Ishtiwi. "Cyclooxygenase-2 (cox-2) expression in Barrett's oesphageal epithelium : relationship to inflammation and cancer." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418127.

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20

Gagnaire, Aurelie. "Rôle de la voie COX-2 au cours de l'infection par Brucella." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4054.

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Brucella est une bactérie intracellulaire facultative à Gram négatif responsable d’une zoonose, la brucellose. Pour persister dans l’organisme, Brucella agit comme un pathogène furtif en modulant la réponse immunitaire de l’hôte. La cyclooxygénase 2 (COX-2) est l’enzyme responsable de la synthèse des prostanoïdes, des médiateurs lipidiques dérivés de l’acide arachidonique (AA) présentant des propriétés immunorégulatrices. Cette thèse est centrée sur l’étude de cette voie métabolique au cours de l’infection par Brucella in vitro dans des cellules dendritiques (DC) humaines et murines ainsi qu’i

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21

Marques, Daniela Cristina Sobreiro. "Avaliação da expressão da Cox-2 em tumores mamários de cadela." Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2013. http://hdl.handle.net/10400.5/6222.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A ciclooxigenase-2 (COX-2) é uma proteína que se encontra envolvida na oncogénese e na inflamação, tendo sido demonstrada a sua sobrexpressão em diversas neoplasias humanas e animais. Nos tumores mamários esta enzima está associada a indicadores de pior prognóstico, tanto na mulher como na cadela. Adicionalmente, a utilização de fármacos inibidores da COX-2 demonstrou uma diminuição da incidência e da capacidade metastática em mulheres portadoras de cancro da mama. Também nos tumores mamários de cadela existe a evidência de que

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22

Gu, Baoying. "Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy : effects of nimesulide." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112627.

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Wernicke's encephalopathy is a neuropsychiatric disorder resulting from thiamine deficiency (TD) and is characterized by neuronal loss, astrocytic proliferation and microglial activation. Cyclooxygenases (COX) are enzymes which catalyze the first step in the synthesis of prostanoids. COX-1 is expressed constitutively and COX-2 is the inducible isoform. Groups of TD rats and pair-fed controls were killed at presymptomatic and symptomatic stages of encephalopathy. Cresyl violet and NeuN staining showed decreased numbers of neuronal cells in vulnerable regions (medial thalamus and inferior collic

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23

Lee, Jonathan J. "Studies on the Roles of Translationally Recoded Proteins from Cyclooxygenase-1 and Nucleobindin Genes in Autophagy." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/6538.

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Advances in next-generation sequencing and ribosomal profiling methods highlight that the proteome is likely orders of magnitude larger than previously thought. This expansion potentially occurs through translational recoding, a process that results in the expression of multiple variations of a protein from a single messenger RNA. Our laboratory demonstrated that cyclooxygenase-3/1b (COX-3/1b), a frameshifted, intron-1-retaining, alternative splice variant from the COX-1 gene, is multiply recoded, which results in the translation of at least seven different COX-3 proteins. Two of the recoded C

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24

Kommareddy, Madhavi. "Upregulation of COX-2 protein expression in porcine macula densa with L-NAME treatment." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6073.

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Thesis (M.S.)--University of Missouri-Columbia, 2008.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Includes bibliographical references.

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25

Laube, Markus. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET." Doctoral thesis, Technische Universität Dresden, 2014. https://tud.qucosa.de/id/qucosa%3A28510.

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Eine erhöhte COX-2-Expression wird bei Krankheiten wie rheumatoider Arthritis aber auch Parkinson, Alzheimer und Krebs beobachtet. Die nichtinvasive Visualisierung und Quantifizierung der COX 2-Expression in vivo mittels Positronen-Emissions-Tomographie (PET) könnte wertvolle Beiträge zur Diagnose dieser Krankheiten liefern. Zur Nutzung der PET-Technik werden geeignete COX-2-adressierende Radiotracer benötigt, deren Entwicklung auch die Identifizierung neuer, der Radiomarkierung zugänglicher COX-2-Inhibitoren als Leitstrukturen voraussetzt. Ziel dieser Arbeit war die Synthese von selektiven,

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26

Mehar, Ayaz. "Inhibitors of cyclooxygenase-2 (COX-2) and prostate cancer : effects on apoptosis and role in tumour inhibition." Thesis, University of Surrey, 2005. http://epubs.surrey.ac.uk/843556/.

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In comparison to other cancers, advanced prostate cancer is resistant to chemotherapy. There is a need to understand the mechanisms which are responsible for this resistance and find better treatments for this disease or methods to increase the efficacy of current treatments. Cancer cells often evade apoptosis. Cyclooxygenase-2 (COX-2) is an enzyme reported to be elevated in prostate cancer, and has oncogenic properties, including apoptosis attenuation. Because of this, COX-2 inhibition could be beneficial for both prevention and treatment of cancer. This study showed that COX-2 protein was no

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27

Laube, Markus. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-160091.

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Eine erhöhte COX-2-Expression wird bei Krankheiten wie rheumatoider Arthritis aber auch Parkinson, Alzheimer und Krebs beobachtet. Die nichtinvasive Visualisierung und Quantifizierung der COX 2-Expression in vivo mittels Positronen-Emissions-Tomographie (PET) könnte wertvolle Beiträge zur Diagnose dieser Krankheiten liefern. Zur Nutzung der PET-Technik werden geeignete COX-2-adressierende Radiotracer benötigt, deren Entwicklung auch die Identifizierung neuer, der Radiomarkierung zugänglicher COX-2-Inhibitoren als Leitstrukturen voraussetzt. Ziel dieser Arbeit war die Synthese von selektiven,

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28

Scheer, Martin-Jürgen [Verfasser]. "Die Rolle der Cyclooxygenase-2-(COX-2)-Expression auf Prognose und Therapie oraler Plattenepithelkarzinome / Martin-Jürgen Scheer." Köln : Deutsche Zentralbibliothek für Medizin, 2011. http://d-nb.info/1017871841/34.

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29

Sheridan, Jared. "Partnership between the aryl hydrocarbon receptor (AHR) and RELB regulates cigarette smoke-induced cyclooxygenase-2 (COX-2) expression." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123307.

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Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lungs caused by cigarette smoke exposure; COPD is also now the third leading cause of death worldwide. Controlling lung inflammation is a priority in COPD patients, but currently-available medications offer little relief. Thus, new therapeutic targets represent a major unmet need. Previously, the aryl hydrocarbon receptor (AHR) has been shown to suppress cigarette smoke-induced inflammation. The AHR is a ligand-activated transcription factor, and well-established for its response to xenobiotic ligands. AHR-mediated

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30

Garrelfs, Nicklas [Verfasser], Jessica [Akademischer Betreuer] Günzle, and Astrid [Akademischer Betreuer] Weyerbrock. "Die Hemmung der Cyclooxygenase (COX) durch Acetylsalicylsäure (ASS) verstärkt die Antitumorwirkung von JS-K bei Glioblastomen in vitro." Freiburg : Universität, 2021. http://d-nb.info/1229835245/34.

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31

Serra, Kátia Piton 1979. "Expressão da COX-2 em carcinomas de mama intraductais e invasores e sua relação com a expressão de HER-2, p53 e receptores de estrógeno e progesterona." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312150.

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Orientadores: Sophie Françoise Mauricette Derchain, Luis Otávio Zanatta Sarian<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-16T22:51:42Z (GMT). No. of bitstreams: 1 Serra_KatiaPiton_M.pdf: 1719188 bytes, checksum: fd6b0e67d77fd1b8fce08cde3c09dd45 (MD5) Previous issue date: 2010<br>Resumo: Introdução: evidências laboratoriais sugerem que a enzima ciclooxigenase-2 (COX-2), é um dos principais componentes da cascata inflamatória. A enzima é responsável pela conversão do ácido araquidônico em prostaglandinas e

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32

Yeoh, Ann Suk Jing. "Nuclear factor kB (NFkB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is association with subsequent histopathologic changes /." Title page and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09MSB/09msby46.pdf.

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33

Lin, Ho-Pi. "Celecoxib its non-COX-2 targets and its anti-cancer effects /." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1124114562.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xix, 94 p.; also includes graphics (some col.). Includes bibliographical references (p. 87-94). Available online via OhioLINK's ETD Center

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34

Sawdy, Robert John. "The role of the type-2 isoform of the cyclooxygenase enzyme (COX-2) in human parturition : potential benefits of selective COX-2 inhibitors in the management of preterm labour." Thesis, Imperial College London, 2003. http://hdl.handle.net/10044/1/11444.

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35

László, Csaba F. "Translation regulation of UV-light-induced transcription factor NF-kappa-B and oncogene COX-2." View abstract, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3353542.

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Öztürk, Özlem Altuntaş İrfan. "Yaşlı ratlarda selektif ve non selektif cox inhibitörlerinin NMDA reseptör subunitlerine etkisi /." Isparta: SDÜ Tıp Fakültesi, 2006. http://tez.sdu.edu.tr/Tezler/TT00268.pdf.

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Godinho, Camila Capel. "Análise metabolômica da bioatividade em vias COX e LOX-dependentes de plantas da subtribo Lychnophorinae." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-03102016-143050/.

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Muitas substâncias das espécies de Lychnophorinae (Asteraceae) são relatadas como inibidoras da síntese de mediadores da cascata do processo inflamatório. Nesse processo, duas enzimas são essenciais e atuam no metabolismo do ácido araquidônico, formado em processos inflamatórios: ciclooxigenase (COX) e lipoxigenase (LOX). A análise de impressões digitais metabólicas é um método capaz de fornecer informações sobre o objeto de estudo através da utilização de ferramentas estatísticas, além de possibilitar a correlação desses dados com outros utilizando métodos in silico. O objetivo deste estudo f

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Mouawad, Charbel. "Effets pleiotropiques des statines : un rôle anti-inflammatoire impliquant la HO-1 et antifibrogénique impliquant la COX-2." Paris 7, 2009. http://www.theses.fr/2009PA077156.

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Les statines sont des inhibiteurs compétitifs de la HMG-CoA réductase, enzyme essentielle dans la voie du mévalonate aboutissant à la biosynthèse du cholestérol. Elles possèdent des propriétés anti-inflammatoires, antiprolifératives, anti-oxydantes et anti-thrombotiques leur conférant un puissant effet protecteur. Les hème-oxygénases sont les enzymes responsables du catabolisme de Thème pour libérer la Fe²⁺, la bilirubine et le monoxyde de carbone. Les deux derniers produits sont responsables des propriétés protectrices. Une large variété de stimuli est capable d'induire l'expression de la hèm

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Almeida, Paulo Roberto Carvalho de. "ImunoexpressÃo de ciclooxigenase-2 (COX-2) e caderina-e no cÃncer gÃstrico: contribuiÃÃo ao estudo da progressÃo tumoral-linfonodal." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1222.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>COX-2 e Caderina-E participam de forma fundamental na manutenÃÃo do estado fisiolÃgico da mucosa gÃstrica e tÃm papel essencial na reaÃÃo inflamatÃria e reparo, e no cÃncer. O objetivo deste trabalho Ã avaliar a expressÃo das duas proteÃnas no carcinoma gÃstrico e metÃstases linfonodais e suas possÃveis participaÃÃes na progressÃo tumoral. Foram utilizados 97 casos de gastrectomias por carcinoma gÃstrico, 36 dos quais com linfonodos disponÃveis, dos arquivos do Hospital do CÃncer do CearÃ. Os casos foram classificados nos tipos int

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Tomitão, Michele Tatiana Pereira. "Análise de polimorfismos do gene ciclooxigenase-2 (COX-2) no câncer colorretal." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-20042016-142620/.

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A População brasileira apresenta elevada diversidade genética devido à multietnicidade, que têm implicações clínicas/genéticas importantes. O estudo de genes polimórficos pode auxiliar na detecção de pessoas com maior risco de desenvolver câncer, caracterização de evolução diferenciada, resposta distinta ao tratamento quimioterápico ou radioterápico e prognóstico. A ciclooxigenase-2 (COX-2) é induzida em resposta ao fator de crescimento e citocinas, sendo expressa nas doenças inflamatórias, lesões pré-malignas e tumores colorretais. Este trabalho teve como objetivos avaliar a influência dos po

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Valkealahti, M. (Maarit). "The effects of bisphosphonates and COX-2 inhibitors on the bone remodelling unit." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514288548.

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Abstract Bone remodelling occurs in humans throughout life, therefore bone is continuously renewed to better respond to changes in weightbearing circumstances. Bone remodelling is extremely vulnerable during fracture healing and integration of prostheses into the surrounding bone. Bone remodelling is a complex system in which many growth factors, cytokines and enzymes, which are essential for the differentiation of osteoblasts and osteoclasts, are involved. Some widely used drugs can affect this sensitive system of remodellation in unexpected manner. Painkillers such as cyclooxygenase (COX) in

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An, Ying. "Cell-Type Specific Actions of Inflammatory Mediators in the CNS." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460544960.

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Davies, Richard. "Effect of selective COX-2 inhibitors on hepatic progenitor cells and the pathologies of experimental hepatocarcinogenesis." University of Western Australia. School of Medicine and Pharmacology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0190.

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[Truncated abstract] Hepatocellular carcinoma (HCC) is the major malignancy complicating chronic liver disease. New therapies for the prevention of HCC are required due to the limited success and high tumour recurrence rates of existing treatments. Emerging evidence suggests that HCC arise from the transformation of adult liver progenitor cells (LPCs), which have the capacity to differentiate into hepatocytes and biliary cells during liver regeneration. LPC activation precedes neoplasia in experimental hepatocarcinogenesis. LPCs share antigenic epitopes with HCCs, including α-fetoprotein (AFP)

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Pinheiro, Anderson 1981. "Receptores de estrógeno e progesterona, Ki67, Bcl-2 E Cox-2 em pólipos endometriais de mulheres na pré e pós-menopausa e associação com a obesidade, : Estrogen and progesterone receptors, Ki67, Bcl-2 and Cox-2 markers in benign endometrial polyps in pre and postmenopausal women and their association with obesity." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310480.

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Orientador: Lúcia Helena Simões da Costa Paiva<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-11-07T13:42:39Z (GMT). No. of bitstreams: 1 Pinheiro_Anderson_M.pdf: 3122120 bytes, checksum: dced5efa50ee11a7d5554366020908bb (MD5) Previous issue date: 2012<br>Resumo: Introdução: A prevalência de obesidade tem aumentado em todo o mundo e hoje já representa um problema de saúde pública. Na população feminina, seu aumento ocorre principalmente nos anos próximos da transição para menopausa. O aumento de peso representa

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Hoxha, M. "THE POTENTIAL THERAPEUTIC ROLE OF MONTELUKAST AND NEW HYBRID AGENTS, TXA2 ANTAGONIST-COX-2 INHIBITORS IN CARDIOVASCULAR EVENTS." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/347148.

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The main target of my PhD research project was to explore new alternatives to reduce the cardiovascular (CV) risk targeting the arachidonic acid metabolites. Hence, I have been part of two different projects, one studying multitarget compounds with balanced COXIB and TP receptor antagonist properties, and the other evaluating the potential role of a leukotriene (LT) antagonist drug such as montelukast in improving the CV outcome. In reference to the first project, new multitarget compounds were synthesized at the University of Turin, by substituting the carboxylic function of Lumiracoxib.

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Elliott, Christopher S. "The Chemoprevention of Lung Cancer Using Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1041537546.

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Laube, Markus [Verfasser], Torsten Akademischer Betreuer] Kniess, Jens [Akademischer Betreuer] [Pietzsch, Jörg Akademischer Betreuer] Steinbach, and Thomas [Akademischer Betreuer] [Henle. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET / Markus Laube. Gutachter: Jörg Steinbach ; Thomas Henle. Betreuer: Torsten Kniess ; Jens Pietzsch ; Jörg Steinbach." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://d-nb.info/1069093106/34.

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Laube, Markus Verfasser], Torsten [Akademischer Betreuer] Kniess, Jens [Akademischer Betreuer] [Pietzsch, Jörg Akademischer Betreuer] Steinbach, and Thomas [Akademischer Betreuer] [Henle. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET / Markus Laube. Gutachter: Jörg Steinbach ; Thomas Henle. Betreuer: Torsten Kniess ; Jens Pietzsch ; Jörg Steinbach." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://d-nb.info/1069093106/34.

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Ronkainen, H. L. (Hanna-Leena). "Novel prognostic biomarkers for renal cell carcinoma." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514297731.

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Abstract Background and aims: Stage and grade are the most widely used prognostic parameters for renal cell carcinoma (RCC). The clinical course of this disease is not, however, always predictable by traditional prognostic factors. In the era of new molecular targeted therapies a more accurate prognostication of RCC patient survival is important for the individualization of treatment and follow-up of patients. Despite exhaustive research there are still no prognostic biomarkers for RCC in clinical practice. In order to find novel prognostic tissue markers for RCC, we examined the expression of

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Liu, Tongzheng. "Regulation of Inflammtory Activation in Endothelial Cells by PIN1." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1242756227.

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