Academic literature on the topic 'Cyclopeptoids'

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Journal articles on the topic "Cyclopeptoids"

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Sala, Giorgio Della, Brunello Nardone, Francesco De Riccardis, and Irene Izzo. "Cyclopeptoids: a novel class of phase-transfer catalysts." Org. Biomol. Chem. 11, no. 5 (2013): 726–31. http://dx.doi.org/10.1039/c2ob26764k.

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Comegna, Daniela, Monica Benincasa, Renato Gennaro, Irene Izzo та Francesco De Riccardis. "Design, synthesis and antimicrobial properties of non-hemolytic cationic α-cyclopeptoids". Bioorganic & Medicinal Chemistry 18, № 5 (2010): 2010–18. http://dx.doi.org/10.1016/j.bmc.2010.01.026.

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Schettini, Rosaria, Brunello Nardone, Francesco De Riccardis, Giorgio Della Sala та Irene Izzo. "Cyclopeptoids as Phase-Transfer Catalysts for the Enantioselective Synthesis of α-Amino Acids". European Journal of Organic Chemistry 2014, № 35 (2014): 7793–97. http://dx.doi.org/10.1002/ejoc.201403224.

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Schettini, Rosaria, Brunello Nardone, Francesco De Riccardis, Giorgio Della Sala та Irene Izzo. "ChemInform Abstract: Cyclopeptoids as Phase-Transfer Catalysts for the Enantioselective Synthesis of α-Amino Acids." ChemInform 46, № 18 (2015): no. http://dx.doi.org/10.1002/chin.201518066.

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Della Sala, Giorgio, Irene Izzo, Rosaria Schettini, Assunta D’Amato, and Francesco De Riccardis. "Catalytic Alkylation of 2-Aryl-2-oxazoline-4-carboxylic Acid Esters Using Cyclopeptoids; Newly Designed Phase-Transfer Catalysts." Synthesis 49, no. 06 (2016): 1319–26. http://dx.doi.org/10.1055/s-0036-1588102.

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Schmidt, Ulrich. "Natürliche Cyclopeptide und Cyclopeptolide." Nachrichten aus Chemie, Technik und Laboratorium 37, no. 10 (1989): 1034–43. http://dx.doi.org/10.1002/nadc.19890371006.

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Lepage, Mathieu L., Alessandra Meli, Anne Bodlenner, et al. "Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores." Beilstein Journal of Organic Chemistry 10 (June 23, 2014): 1406–12. http://dx.doi.org/10.3762/bjoc.10.144.

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Cyclic N-propargyl α-peptoids of various sizes were prepared by way of macrocyclizations of linear N-substituted oligoglycines. These compounds were used as molecular platforms to synthesize a series of iminosugar clusters with different valency and alkyl spacer lengths by means of Cu(I)-catalysed azide–alkyne cycloadditions. Evaluation of these compounds as α-mannosidase inhibitors led to significant multivalent effects and further demonstrated the decisive influence of scaffold rigidity on binding affinity enhancements.
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Lepage, Mathieu L., Jérémy P. Schneider, Anne Bodlenner, et al. "Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels." Chemistry - A European Journal 22, no. 15 (2016): 5151–55. http://dx.doi.org/10.1002/chem.201600338.

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Tedesco, Consiglia, Eleonora Macedi, Alessandra Meli, et al. "Synthesis, crystallization, X-ray structural characterization and solid-state assembly of a cyclic hexapeptoid with propargyl and methoxyethyl side chains." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 73, no. 3 (2017): 399–412. http://dx.doi.org/10.1107/s2052520617002505.

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The synthesis and the structural characterization of a cyclic hexapeptoid with four methoxyethyl and two propargyl side chains have disclosed the presence of a hydrate crystal form [form (I)] and an anhydrous crystal form [form (II)]. The relative amounts of form (I) and form (II) in the as-purified product were determined by Rietveld refinement and depend on the purification procedures. In crystal form (I), peptoid molecules assemble in a columnar arrangement by means of side-chain-to-backbone C=CH...OC hydrogen bonds. In the anhydrous crystal form (II), cyclopeptoid molecules form ribbons by
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Harant, Hanna, Barbara Wolff, Erwin P. Schreiner, et al. "Inhibition of Vascular Endothelial Growth Factor Cotranslational Translocation by the Cyclopeptolide CAM741." Molecular Pharmacology 71, no. 6 (2007): 1657–65. http://dx.doi.org/10.1124/mol.107.034249.

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Dissertations / Theses on the topic "Cyclopeptoids"

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Nardone, Brunello. "Synthesis, Structure and Properties of Cyclopeptoids and Cyclopeptides." Doctoral thesis, Universita degli studi di Salerno, 2014. http://hdl.handle.net/10556/1463.

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2012 - 2013<br>Aim of the research project has been the synthesis of cyclopeptides and cyclopeptoids in order to investigate their structural properties and catalytic activities. In particular, studies of the arrangement and the cyclopeptoids organization in the crystal structure have been realized. Moreover, the influence of some aminoacidic residues on conformational control of peptoid skeleton was evaluated. In this context, the effect of proline, an amminoacid with an important role in the formation of secondary protein structures,1 and of a pseudo-proline residue on the cystal structure
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Batisse, Chloé. "Nouvelles voies de synthèse énantiosélective pour l'accès à des composés difluorométhylés." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF041/document.

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En dépit de sa rareté au sein des produits naturels et des processus biologiques, le fluor joue un rôle de plus en plus important dans nos vies quotidiennes. Un atome de fluor ou un groupement fluoré, lorsqu’il fait partie d’une molécule biologiquement active, permet d’améliorer drastiquement ses propriétés physiques, chimiques et biologiques. Le groupement -CHF2, en plus de posséder les propriétés remarquables communes à de nombreuses espèces émergentes fluorées, est considéré comme un bioisostère des groupements hydroxyle, thiol et amino. Il peut également être engagé dans des liaisons de ty
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Lepage, Mathieu. "Conception et synthèse de nouvelles classes d’iminosucres d’intérêt biologique : ingénierie click pour des systèmes multivalents." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF049/document.

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Des résultats récents ont montré les premières preuves d’un effet multivalent puissant des iminosucres sur l’inhibition des glycosidases, avec des gains d’affinité allant jusqu’à 10000. Afin de comprendre les différentes caractéristiques de cet « effet de cluster » et d’en poursuivre l’optimisation, de nouvelles charpentes doivent être conçues. Le premier axe de recherche a donc consisté en la mise au point d’un ensemble de techniques d’ingénierie « click » pour la synthèse de systèmes multivalents, avec le développement d’une stratégie Sweet LEGO®. Cette approche permettrait un accès simple à
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POURTIER, ALBIN. "Description et caracterisation d'agents modulant la resistance tumorale pleiotropique mediee par la p-glycoproteine." Strasbourg 1, 1993. http://www.theses.fr/1993STR15096.

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Schneider, Jérémy. "Synthèse d'une diversité de glycoclusters : effet multivalent sur l'inhibition des glycosidases." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF005.

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Les premiers iminosucres multivalents rapportés dans la littérature datent de 1999. Depuis, c’est plus d’une centaine de clusters de ce type qui ont été synthétisés et décrits une quarantaine de publications. L’obtention d’un premier effet multivalent fort sur une glycosidase, en 2010, a initié de nouveaux travaux visant à étudier et à comprendre son mécanisme et ses limites. Dans cette optique le présent travail de thèse a exploité plusieurs approches. La première partie décrit la synthèse de dendrons "cliquables" permettant de multiplier par trois ou par neuf la valence initiale des platefor
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Conference papers on the topic "Cyclopeptoids"

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Oberhauser, B., B. Grohmann, and H. Sperner. "Selective Epimerisation of a Fungal Cyclopeptolide via an 2-Amino-oxazole Intermediate - Conformational Consequences." In The 2nd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1998. http://dx.doi.org/10.3390/ecsoc-2-01702.

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