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Relevant bibliographies by topics / Cyclopropyl moiety

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Academic literature on the topic 'Cyclopropyl moiety'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Cyclopropyl moiety"

1

Časar, Zdenko. "Synthetic Approaches to Contemporary Drugs that Contain the Cyclopropyl Moiety." Synthesis 52, no. 09 (2020): 1315–45. http://dx.doi.org/10.1055/s-0039-1690058.

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The U.S. Food and Drug Administration approved 18 new drugs that incorporate the cyclopropyl structural motif in the time frame from 2012 to 2018. This review provides an overview of synthetic approaches to these drugs with emphasis on the construction of the cyclopropyl moiety or its incorporation into the key building blocks for assembly of the highlighted drugs. Based on the structural diversity of these drugs, synthetic approaches for the construction and introduction of the cyclopropyl moiety into their structure are diverse and include: cycloalkylation (double alkylation) of CH-acids, ca

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2

Al-Trawneh, Salah A., Amer H. Tarawneh, Anastassiya V. Gadetskaya, et al. "Synthesis and Cytotoxicity of Thieno[2,3-b]Pyridine Derivatives Toward Sensitive and Multidrug-Resistant Leukemia Cells." Acta Chimica Slovenica 68, no. 2 (2021): 458–65. http://dx.doi.org/10.17344/acsi.2020.6609.

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A new series of substituted ethyl 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates 3a–e were prepared by utilizing ethyl 2-chloro-7-cyclopropyl-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate (1) and replacing of the 2-chlorine with anions obtained from phenol (2a), salicylaldehyde derivatives 2b–d or thiophenol (2e), leading to the respective ethyl 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates 3a–e. The new compounds were evaluated for their in vitro cytotoxicity towards sensitive CCRF-CEM and mu

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3

Gorlov, Evgenii S., Diana V. Shuingalieva, Alexey I. Ilovaisky, Vera A. Vil’, and Alexander O. Terent’ev. "1-(((6-(Methoxycarbonyl)-5-oxononan-4-yl)oxy)carbonyl)cyclopropane-1-carboxylic Acid." Molbank 2023, no. 2 (2023): M1651. http://dx.doi.org/10.3390/m1651.

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Here, we first report the 2′-acyloxy-1,3-dicarbonyl compound construction in a three-component oxidative reaction of alkyl ketene dimer with cyclic diacyl peroxide and trimethyl orthoformate. The discovered synthesis allows us to form 2′-functionalized 1,3-dicarbonyl compounds instead of the common 2-functionalized moiety. The reaction between 4-butylidene-3-propyloxetan-2-one and cyclopropyl malonoyl peroxide proceeds in the presence of trifluoroacetic acid and trimethyl orthoformate at 120 °C for 1 h. The synthesized compound was characterized by NMR spectroscopy, mass spectrometry, and IR s

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4

Burmudžija, Adrijana, Jovana M. Muškinja, Marijana M. Kosanic, et al. "Cytotoxic Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives." Chem Biodivers 2017, Epub (2017): Jul 1. https://doi.org/10.1002/cbdv.201700077.

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A small series of 1‐acetyl‐2‐(4‐alkoxy‐3‐methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐buten‐2‐one) and its O‐alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative

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5

Alipour, Eskandar, Negar Mohammad Hosseini, Fatemeh Panah, et al. "Synthesis andIn VitroCytotoxic Activity ofN-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives." E-Journal of Chemistry 8, no. 3 (2011): 1226–31. http://dx.doi.org/10.1155/2011/842982.

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Quinolone are a class of potent broad-spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series ofN-pipearzinyl quinolones containingN-2-(furyl-2-yl)-2-(chlorobenzyloxyimino) ethyl moiety(6a-c)have been studied. Preliminary screening showed that one of the new compounds, namely 7-(4-(2-(3-chlorobenzyloxyimino)-2-(furan-2-yl) ethyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid(6b)showed significant cytotoxi

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6

Bechi, Beatrice, David Amantini, Cristina Tintori, Maurizio Botta, and Romano di Fabio. "Stereocontrolled synthesis of 5-azaspiro[2.3]hexane derivatives as conformationally “frozen” analogues of L-glutamic acid." Beilstein Journal of Organic Chemistry 10 (May 14, 2014): 1114–20. http://dx.doi.org/10.3762/bjoc.10.110.

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Several strategies aimed to “freeze” natural amino acids into more constrained analogues have been developed with the aim of enhancing in vitro potency/selectivity and, more in general, drugability properties. The case of L-glutamic acid (L-Glu, 1) is of particular importance since it is the primary excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a critical role in a wide range of disorders like schizophrenia, depression, neurodegenerative diseases such as Parkinson’s and Alzheimer’s and in the identification of new potent and selective ligands of ionotropic

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7

Li, Penghui, Qingyang Xie, Fuxian Wan, Yuanhong Zhang, and Lin Jiang. "Synthesis and Fungicidal Activity of Novel Substituted Pyrimidine-5-carboxamides Bearing Cyclopropyl Moiety." Chinese Journal of Organic Chemistry 44, no. 2 (2024): 650. http://dx.doi.org/10.6023/cjoc202307029.

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8

Kratzel, M. "Synthesis of aC-nor-morphin-6-ene by radicalic isomerization of a cyclopropyl moiety." Monatshefte f�r Chemie - Chemical Monthly 125, no. 6-7 (1994): 791–93. http://dx.doi.org/10.1007/bf01277641.

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9

Craig, Alexander J., та Bill C. Hawkins. "The Bonding and Reactivity of α-Carbonyl Cyclopropanes". Synthesis 52, № 01 (2019): 27–39. http://dx.doi.org/10.1055/s-0039-1690695.

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The cyclopropane functionality has been exploited in a myriad of settings that range from total synthesis and methodological chemistry, to medical and materials science. While it has been seen in such a breadth of settings, the typical view of the cyclopropane moiety is that its reactivity is derived primarily from the release of ring strain. While this simplified view is a useful shorthand, it ignores the specific nature of cyclopropyl molecular orbitals. This review aims to present the different facets of cyclopropane bonding by examining the main models that have been used to explain the re

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10

Boztas, Murat, Parham Taslimi, Mirali Akbar Yavari, Ilhami Gulcin, Ertan Sahin, and Abdullah Menzek. "Synthesis and biological evaluation of bromophenol derivatives with cyclopropyl moiety: Ring opening of cyclopropane with monoester." Bioorganic Chemistry 89 (August 2019): 103017. http://dx.doi.org/10.1016/j.bioorg.2019.103017.

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Book chapters on the topic "Cyclopropyl moiety"

1

Dourtoglou, V., E. Koussissi, and K. Petritis. "Evaluation of Novel Inhibitors of ACC Oxidase Possessing Cyclopropyl Moiety." In Biology and Biotechnology of the Plant Hormone Ethylene II. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4453-7_3.

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