Relevant bibliographies by topics / Cynomolgus macaque

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Cynomolgus macaque'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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Journal articles on the topic "Cynomolgus macaque"

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DiVincenti, L., A. Rehrig, and J. Wyatt. "Interspecies pair housing of macaques in a research facility." Laboratory Animals 46, no. 2 (2012): 170–72. http://dx.doi.org/10.1258/la.2011.011134.

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The eighth edition of The Guide for the Care and Use of Laboratory Animals establishes social housing as the ‘default’ for social species including non-human primates. The advantages of social housing for primates have been well established, but small research facilities housing few primates in indoor cages have struggled with social housing as a result of limitations on appropriate housing and availability of compatible monkeys. Here, we report a novel approach to pair housing macaques – crossing species. We have successfully pair housed an intact male rhesus macaque with an intact male cynom
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Smith, Autumn L., Darla H. Black, and R. Eberle. "Molecular Evidence for Distinct Genotypes of Monkey B Virus (Herpesvirus Simiae) Which Are Related to the Macaque Host Species." Journal of Virology 72, no. 11 (1998): 9224–32. http://dx.doi.org/10.1128/jvi.72.11.9224-9232.1998.

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ABSTRACT Although monkey B virus (herpesvirus simiae; BV) is common in all macaque species, fatal human infections appear to be associated with exposure to rhesus macaques (Macaca mulatta), suggesting that BV isolates from rhesus monkeys may be more lethal to nonmacaques than are BV strains indigenous to other macaque species. To determine if significant differences that would support this supposition exist among BV isolates, we compared multiple BV strains isolated from rhesus, cynomolgus, pigtail, and Japanese macaques. Antigenic analyses indicated that while the isolates were very closely r
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Huang, Xia, Shijia Li, Xiaoming Liu, Shuting Huang, Shuang Li, and Min Zhuo. "Analysis of conserved miRNAs in cynomolgus macaque genome using small RNA sequencing and homology searching." PeerJ 8 (July 10, 2020): e9347. http://dx.doi.org/10.7717/peerj.9347.

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MicroRNAs (miRNAs) are important regulators that fine-tune diverse cellular activities. Cynomolgus macaques (Macaca fascicularis) are used extensively in biomedical and pharmaceutical research; however, substantially fewer miRNAs have been identified in this species than in humans. Consequently, we investigated conserved miRNA profiles in cynomolgus macaques by homology searching and small RNA sequencing. In total, 1,455 high-confidence miRNA gene loci were identified, 408 of which were also confirmed by RNA sequencing, including 73 new miRNA loci reported in cynomolgus macaques for the first
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Shiina and Blancher. "The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine." Cells 8, no. 9 (2019): 978. http://dx.doi.org/10.3390/cells8090978.

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Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer to humans than rodents, which are still the most frequently used animal model. Our understanding of the Mafa genome has progressed rapidly in recent years and has greatly benefited from the latest technical advances in molecular genetics. Cynomolgus macaques are widespread in Southeast Asia and numer
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Sawaswong, Vorthon, Elizabeth Fahsbender, Eda Altan, et al. "High Diversity and Novel Enteric Viruses in Fecal Viromes of Healthy Wild and Captive Thai Cynomolgus Macaques (Macaca fascicularis)." Viruses 11, no. 10 (2019): 971. http://dx.doi.org/10.3390/v11100971.

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Cynomolgus macaques are common across South East Asian countries including Thailand. The National Primate Research Center of Thailand, Chulalongkorn University (NPRCT-CU) captures wild-borne cynomolgus macaque for research use. Limited information is available on the enteric viruses and possible zoonotic infections into or from cynomolgus macaques. We characterized and compare the fecal virome of two populations; healthy wild-originated captive cynomolgus macaques (n = 43) reared in NPRCT-CU and healthy wild cynomolgus macaques (n = 35). Over 90% of recognized viral sequence reads amplified fr
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Saito, Akatsuki, Ken Kono, Masako Nomaguchi, et al. "Geographical, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis)." Journal of General Virology 93, no. 3 (2012): 594–602. http://dx.doi.org/10.1099/vir.0.038075-0.

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The antiretroviral factor tripartite motif protein 5 (TRIM5) gene-derived isoform (TRIMCyp) has been found in at least three species of Old World monkey: rhesus (Macaca mulatta), pig-tailed (Macaca nemestrina) and cynomolgus (Macaca fascicularis) macaques. Although the frequency of TRIMCyp has been well studied in rhesus and pig-tailed macaques, the frequency and prevalence of TRIMCyp in cynomolgus macaques remain to be definitively elucidated. Here, the geographical and genetic diversity of TRIM5α/TRIMCyp in cynomolgus macaques was studied in comparison with their anti-lentiviral activity. It
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Huang, Shuting, Xia Huang, Shuang Li, Mingjun Zhu, and Min Zhuo. "MHC class I allele diversity in cynomolgus macaques of Vietnamese origin." PeerJ 7 (November 4, 2019): e7941. http://dx.doi.org/10.7717/peerj.7941.

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Cynomolgus macaques (Macaca fascicularis, Mafa) have been used as important experimental animal models for carrying out biomedical researches. The results of biomedical experiments strongly depend on the immunogenetic background of animals, especially on the diversity of major histocompatibility complex (MHC) alleles. However, there is much less information available on the polymorphism of MHC class I genes in cynomolgus macaques, than is currently available for humans. In this study, we have identified 40 Mafa-A and 60 Mafa-B exons 2 and 3 sequences from 30 unrelated cynomolgus macaques of Vi
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Reimann, Keith A., Robert A. Parker, Michael S. Seaman, et al. "Pathogenicity of Simian-Human Immunodeficiency Virus SHIV-89.6P and SIVmac Is Attenuated in Cynomolgus Macaques and Associated with Early T-Lymphocyte Responses." Journal of Virology 79, no. 14 (2005): 8878–85. http://dx.doi.org/10.1128/jvi.79.14.8878-8885.2005.

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ABSTRACT Because most studies of AIDS pathogenesis in nonhuman primates have been performed in Indian-origin rhesus macaques (Macaca mulatta), little is known about lentiviral pathogenicity and control of virus replication following infection of alternative macaque species. Here, we report the consequences of simian-human immunodeficiency virus SHIV-89.6P and SIVmac251 infection in cynomolgus (Macaca fascicularis) and rhesus macaques of Chinese origin. Compared to the pathogenicity of the same viruses in Indian rhesus macaques, both cynomolgus and Chinese rhesus macaques showed lower levels of
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Graham, V. A., G. J. Hatch, K. R. Bewley, et al. "Efficacy of Primate Humoral Passive Transfer in a Murine Model of Pneumonic Plague Is Mouse Strain-Dependent." Journal of Immunology Research 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/807564.

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New vaccines against biodefense-related and emerging pathogens are being prepared for licensure using the US Federal Drug Administration’s “Animal Rule.” This allows licensure of drugs and vaccines using protection data generated in animal models. A new acellular plague vaccine composed of two separate recombinant proteins (rF1 and rV) has been developed and assessed for immunogenicity in humans. Using serum obtained from human volunteers immunised with various doses of this vaccine and from immunised cynomolgus macaques, we assessed the pharmacokinetic properties of human and cynomolgus macaq
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Johnston, Sara C., Keersten M. Ricks, Alexandra Jay, et al. "Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure." PLOS ONE 16, no. 2 (2021): e0246366. http://dx.doi.org/10.1371/journal.pone.0246366.

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Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to determine critical disease parameters associated with disease progression, and establish correlations between primate and human COVID-19. Respiratory abnormalities and viral shedding were noted for all anim
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Dissertations / Theses on the topic "Cynomolgus macaque"

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Lemaitre, Julien. "Heterogeneity of polymorphonuclear neutrophils in HIV-1 infection. Study of SIV-infected cynomolgus macaque model." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS267.

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La persistance du VIH-1 est associée au maintien de l’inflammation chronique chez les patients infectés, malgré la mise en place de combinaison de traitements antirétroviraux. L’inflammation chronique est associée à un risque augmenté de développer des comorbidités, non associées au SIDA. Les polynucléaires neutrophiles (PNN) sont des cellules myéloïdes qui ont été impliqués dans de multiples maladies inflammatoires chroniques. Néanmoins, leur rôle dans l’infection par le VIH-1 est moins bien connue. Afin de pallier ce manque de connaissances, nous avons évalué l’hétérogénéité des PNNs dans le
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Peruchon, Sandrine. "Altérations du compartiment B lors de l'infection précoce du macaque Cynomolgus par le Virus de l'Immunodéficience Simienne." Saint-Etienne, 2007. http://www.theses.fr/2007STET010T.

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L'infection par le VIH induit des dysfonctionnements du compartiment B. Ainsi les organes lymphoïdes constitués de follicules secondaires, structures essentielles à la différenciation des LB en cellules mémoires et productrices d'Ac, sont le site d'une réplication intense du virus et leur organisation, comme la réponse humorale, est profondément altérée. La persistance du virus induit une stimulation chronique des cellules immunitaires qui aboutit à une hyperactivation cellulaire. Nos travaux ont montré des caractéristiques des réponses humorales lors des phases précoces (modèle macaque/SIV) e
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Romain, Gabrielle. "Utilisation de cellules dendritiques en vaccination thérapeutique anti-VIH : approche expérimentale chez le macaque." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T040.

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Les lymphocytes T CD8+ jouent un rôle prépondérant dans le contrôle de l’infection par le VIH suggérant ainsi qu’un vaccin efficace doit induire une réponse cellulaire T CD8+ robuste et durable.En fournissant une source antigénique importante qui fait défaut chez les patients répondeurs aux poly-chimiothérapies antirétrovirales, la vaccination thérapeutique pourrait favoriser ce type de réponse cellulaire, non restaurée par les seuls traitements antirétroviraux. Les cellules dendritiques (DC) autologues, qu’elles soient chargées en virus inactivé, en peptides viraux ou en ARN messagers (ARNm)
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Grandin, Clément. "Développement d'un modèle d'infection par le virus respiratoire syncytial humain chez le macaque cynomolgus pour l'évaluation de molécules antivirales candidates." Paris 7, 2014. http://www.theses.fr/2014PA077181.

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Le Virus Respiratoire Syncytial humain (hVRS) est en général responsable d'infections bénignes des voies respiratoires supérieures, mais il est également associé à des infections pulmonaires chez les nouveau-nés et les personnes âgées ou immunodéprimées. L'arsenal thérapeutique contre le hVRS est extrêmement limité. L'Unité de Génomique Virale et Vaccination de l'Institut Pasteur a isolé deux familles de composés chimiques capables d'inhiber la biosynthèse de novo des pyrimidines, présentant une puissante activité antivirale in vitro, et capables d'inhiber la réplication de nombreux virus à AD
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Mederle-Mangeot, Isabelle. "Immunogénicité de souches de Mycobacterium bovis BCG recombinant exprimant des gènes du Virus de l'Immunodéficience Simienne VISmac251 chez le macaque Cynomolgus." Paris 6, 2002. http://www.theses.fr/2002PA066256.

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Derdouch, Sonia. "Transfert de gène dans les cellules médullaires CD34+ : étude chez le macaque cynomolgus de la reconstitution des lignées lymphoïdes et myéloïdes après irradiation gamma." Paris 11, 2005. http://www.theses.fr/2005PA11T063.

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Adam, Lucille. "Dynamique de la réponse immunitaire précoce mise en place localement suite à l’injection d’un vaccin ADN associée à une électroporation chez le macaque cynomolgus." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114812/document.

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La compréhension des mécanismes immunologiques précoces mis en place suite à l’administration de vaccins est encore de nos jours largement méconnue. Pourtant de plus en plus d’études démontrent l’importance de ces mécanismes très précoces faisant intervenir les acteurs de l’immunité innée dans la génération d’une réponse spécifique efficace après vaccination. La peau est un organe intéressant pour l'administration de vaccins du fait de sa richesse en cellules présentatrices d'antigènes (APC), qui sont des cellules essentielles dans la mise en place de la réponse immunitaire. L'administration p
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Bonhomme, Maxime. "Processus démographiques et sélectifs expliquant les profils de diversité et de différenciation génétique des populations du macaque cynomolgus (Macaca fascicularis), espèce à vaste distribution discontinue." Toulouse 3, 2006. http://www.theses.fr/2006TOU30118.

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Le macaque cynomolgus (Macaca fascicularis fascicularis, Cercopithecidae, Primate) occupe actuellement une vaste aire de répartition discontinue dans l’Asie du Sud-Est. Au cours de l’histoire évolutive de cette espèce très «insulaire», deux types de processus ont très certainement façonné la variabilité et la différenciation génétique des populations: (i) des processus démographiques liés aux variations de taille des populations, à leur isolement et aux migrations et (ii) des processus de sélection en relation avec la diversité et la pression sélective des pathogènes, qui pourraient être spéci
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Becard, Nicolas. "Thérapie génique des cellules de la moelle osseuse : application, chez le macaque cynomolgus, au traitement de l'aplasie medullaire après une exposition corporelle totale aux rayonnements gamma." Paris 5, 2003. http://www.theses.fr/2003PA05P637.

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L'objectif de ce travail a été d'augmenter la production in situ, dans la moelle osseuse, de l'IL-1a, à l'aide d'une méthode de transfert de gène pour le traitement de l'aplasie médullaire radio-induite. L'administration intra-médullaire de vecteurs adénoviraux codant le gène de l'huIL-1a a été suivie, chez le singe sain non-irradié, d'une augmentation transitoire du nombre de neutrophiles, de monocytes et de plaqettes dans le sang périphérique. Ces augmentations ont été associé à une production locale du gène thérapeutique. Cette stratégie thérapeutique a été évalué chez le macaque exposé a u
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Todorova, Biliana. "Imagerie in vivo de la réponse immune locale à la vaccination par voie intradermique à l’aide d’un ADN plasmidique associée à l’électroporation chez le macaque cynomolgus." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114837.

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L’électroporation (EP) in vivo est utilisée comme stratégie d’amélioration de la réponse immune induite par les vaccins ADN. Cependant son effet sur les acteurs du système immunitaire inné reste méconnu. Dans l’objectif de mettre en évidence le comportement cellulaire sur le site de la vaccination, nous avons développé des approches d’imagerie par fluorescence in vivo chez le macaque. Nos résultats montrent que l’EP locale, augmente non seulement la quantité et la distribution de l’antigène vaccinal, mais induit également la mobilisation et la migration des cellules de Langerhans. De plus, l’E
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Book chapters on the topic "Cynomolgus macaque"

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Curnow, Eliza, and Eric Hayes. "In Vitro Culture of Embryos from the Cynomolgus Macaque (Macaca fascicularis)." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9566-0_22.

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McGrew, Keely. "Pairing Strategies for Cynomolgus Macaques." In Handbook of Primate Behavioral Management. CRC Press, 2017. http://dx.doi.org/10.1201/9781315120652-17.

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Kaplan, J. R., S. B. Manuck, and T. B. Clarkson. "Psychosocial Stress and Atherosclerosis in Cynomolgus Macaques." In Developments in Cardiovascular Medicine. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2587-1_21.

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Adams, Michael R., Jay R. Kaplan, Thomas B. Clarkson, and Donald R. Koritnik. "Endogenous Sex Steroids and Coronary Artery Atherosclerosis in Cynomolgus Macaques." In Cardiovascular Disease. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5296-9_43.

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Kaplan, J. R., M. R. Adams, T. E. Hamm, and T. B. Clarkson. "Psychosocial Phenomena and Female “Protection” from Coronary Artery Atherosclerosis in Cynomolgus Macaques (Macaca Fascicularis)." In Developments in Cardiovascular Medicine. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2587-1_20.

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Jahrling, P. B., T. W. Geisbert, N. K. Jaax, M. A. Hanes, T. G. Ksiazek, and C. J. Peters. "Experimental infection of cynomolgus macaques with Ebola-Reston filoviruses from the 1989–1990 U.S. epizootic." In Imported Virus Infections. Springer Vienna, 1996. http://dx.doi.org/10.1007/978-3-7091-7482-1_11.

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Koritnik, Donald, Thomas Clarkson, and Michael Adams. "Cynomolgus Macaques as Models for Evaluating Effects of Contraceptive Steroids on Plasma Lipoproteins and Coronary Artery Atherosclerosis." In Contraceptive Steroids. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2241-2_19.

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Borel, Florie, Eric Adams, and Christian Mueller. "Intrathecal Delivery of AAV Vectors in Cynomolgus Macaques for CNS Gene Therapy and Gene Expression Analysis in Microdissected Motor Neurons." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9065-8_19.

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Derdouch, Sonia, Wilfried Gay, Didier Nègre, et al. "Reconstitution of the Myeloid and Lymphoid Compartments after the Transplantation of Autologous and Genetically Modified CD34+ Bone Marrow Cells, Following Gamma Irradiation in Cynomolgus Macaques." In Genetic Engineering. Apple Academic Press, 2011. http://dx.doi.org/10.1201/b12876-9.

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Conference papers on the topic "Cynomolgus macaque"

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Bunting, Haley A., Ryan T. Cassilly, Brian Jin, et al. "Effect of Hormone Therapy on Tensile Strain of the Macaque Inferior Glenohumeral Ligament." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53531.

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The effect of hormone treatment on the material properties of ligaments has been extensively studied for the anterior cruciate ligament (ACL). However, there have been few studies on the effects of hormones on the material properties of the shoulder. Shoulder ligaments contribute to overall shoulder stability, and a change in ligament properties could contribute to a change in overall shoulder laxity. Cynomolgus monkeys have served as nonhuman primate models in studies examining the effects of hormone replacement therapy on the cardiovascular system, as well as serving as a model for menopause
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Gardner, Thomas R., Ryan T. Cassilly, Brian Jin, et al. "Effect of Estrogen on Viscoelastic Properties of the Anterior Pouch of the Macaque Animal Model of the Inferior Glenohumeral Ligament." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206835.

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The effect of hormone treatment on the material properties of ligaments has been extensively studied for the anterior cruciate ligament (ACL). However, there have been very few studies on the effects of hormones on the material properties of the shoulder. These shoulder ligaments contribute to overall shoulder stability, and a change in ligament properties could contribute to a change in overall shoulder laxity. This study uses female cynomologus macaque (Macaca fascicularis) monkeys as an animal model of the human shoulder to determine if estrogen has an effect on the viscoelastic properties
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Caldwell, Jon-Michael E., Ryan T. Cassilly, Haley A. Bunting, et al. "Effects of Hormone Therapy on Regional Surface Strain as a Function of Applied Strain in the Macaque Inferior Glenohumeral Ligament." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80840.

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Hormones such as estrogen are known to have an effect on the biomechanical properties of certain ligaments such as the anterior cruciate ligament in the knee; however, relatively little is known about its effect on the ligaments of the shoulder. The inferior glenohumeral ligament (IGHL) is a static stabilizer of the shoulder that prevents anterior translation of the humeral head. Alterations to the properties of this ligament can result in capsular stretching, increased laxity, and ultimately instability. The cynomolgus macaque (Macaca fascicularis) shares many hormonal similarities with human
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Robinson, Matthew, Ian Strickland, Anthony J. Coyle, Matthew A. Sleeman, Ian A. Anderson, and Richard May. "Thymic Stromal Lymphopoeitin (TSLP) Activates Human And Cynomolgus Macaque Dendritic Cells And Induces Th1 As Well As Th2 Responses In Human Total T Helper Cells." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3794.

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Shipley, Tim, Heather Kling, Alison Morris, Jan Kristoff, Xiuping Shao, and Karen Norris. "Comparison Of Lung Tissue Gene Expression Profiles From SHIV-infected Cynomolgus Macaques With And Without Pneumocystis Colonization-induced COPD." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5208.

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Cini, John K., Darrel J. Rezac, Stephen McAndrew, Susan Dexter, Robert Huebner, and Hossein Borghaei. "Abstract 1589: Toxicity profile of interleukin 12 attached to a fully human albumin binding domain (FHABTM) in Cynomolgus macaques." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1589.

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Gan, L., L. Wu, M. Yao, et al. "Therapy with PPMOs leads to a comprehensive distribution in muscle tissue and efficacy in the mouse model and in cynomolgus macaques: a therapeutic platform for Duchenne muscular dystrophy." In 24. Kongress des Medizinisch-Wissenschaftlichen Beirates der Deutschen Gesellschaft für Muskelkranke (DGM) e.V. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1685092.

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Comeau, Michael R., Rebecca Gottschalk, Mollie Daugherty, et al. "Abstract LB-199: APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity with limited cytokine release, is well tolerated in repeat dose toxicology studies in cynomolgus macaques." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-lb-199.

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Comeau, Michael R., Rebecca Gottschalk, Mollie Daugherty, et al. "Abstract LB-199: APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity with limited cytokine release, is well tolerated in repeat dose toxicology studies in cynomolgus macaques." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-lb-199.

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Reports on the topic "Cynomolgus macaque"

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Jahrling, Peter B., Lisa E. Hensley, Mark J. Martinez, James W. LeDuc, and Kathleen H. Rubins. Exploring the Potential of Variola Virus Infection of Cynomolgus Macaques as a Model for Human Smallpox. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada428737.

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