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Journal articles on the topic 'Cynomolgus macaque'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

DiVincenti, L., A. Rehrig, and J. Wyatt. "Interspecies pair housing of macaques in a research facility." Laboratory Animals 46, no. 2 (2012): 170–72. http://dx.doi.org/10.1258/la.2011.011134.

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The eighth edition of The Guide for the Care and Use of Laboratory Animals establishes social housing as the ‘default’ for social species including non-human primates. The advantages of social housing for primates have been well established, but small research facilities housing few primates in indoor cages have struggled with social housing as a result of limitations on appropriate housing and availability of compatible monkeys. Here, we report a novel approach to pair housing macaques – crossing species. We have successfully pair housed an intact male rhesus macaque with an intact male cynom

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2

Smith, Autumn L., Darla H. Black, and R. Eberle. "Molecular Evidence for Distinct Genotypes of Monkey B Virus (Herpesvirus Simiae) Which Are Related to the Macaque Host Species." Journal of Virology 72, no. 11 (1998): 9224–32. http://dx.doi.org/10.1128/jvi.72.11.9224-9232.1998.

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ABSTRACT Although monkey B virus (herpesvirus simiae; BV) is common in all macaque species, fatal human infections appear to be associated with exposure to rhesus macaques (Macaca mulatta), suggesting that BV isolates from rhesus monkeys may be more lethal to nonmacaques than are BV strains indigenous to other macaque species. To determine if significant differences that would support this supposition exist among BV isolates, we compared multiple BV strains isolated from rhesus, cynomolgus, pigtail, and Japanese macaques. Antigenic analyses indicated that while the isolates were very closely r

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3

Huang, Xia, Shijia Li, Xiaoming Liu, Shuting Huang, Shuang Li, and Min Zhuo. "Analysis of conserved miRNAs in cynomolgus macaque genome using small RNA sequencing and homology searching." PeerJ 8 (July 10, 2020): e9347. http://dx.doi.org/10.7717/peerj.9347.

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MicroRNAs (miRNAs) are important regulators that fine-tune diverse cellular activities. Cynomolgus macaques (Macaca fascicularis) are used extensively in biomedical and pharmaceutical research; however, substantially fewer miRNAs have been identified in this species than in humans. Consequently, we investigated conserved miRNA profiles in cynomolgus macaques by homology searching and small RNA sequencing. In total, 1,455 high-confidence miRNA gene loci were identified, 408 of which were also confirmed by RNA sequencing, including 73 new miRNA loci reported in cynomolgus macaques for the first

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4

Shiina and Blancher. "The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine." Cells 8, no. 9 (2019): 978. http://dx.doi.org/10.3390/cells8090978.

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Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer to humans than rodents, which are still the most frequently used animal model. Our understanding of the Mafa genome has progressed rapidly in recent years and has greatly benefited from the latest technical advances in molecular genetics. Cynomolgus macaques are widespread in Southeast Asia and numer

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Sawaswong, Vorthon, Elizabeth Fahsbender, Eda Altan, et al. "High Diversity and Novel Enteric Viruses in Fecal Viromes of Healthy Wild and Captive Thai Cynomolgus Macaques (Macaca fascicularis)." Viruses 11, no. 10 (2019): 971. http://dx.doi.org/10.3390/v11100971.

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Cynomolgus macaques are common across South East Asian countries including Thailand. The National Primate Research Center of Thailand, Chulalongkorn University (NPRCT-CU) captures wild-borne cynomolgus macaque for research use. Limited information is available on the enteric viruses and possible zoonotic infections into or from cynomolgus macaques. We characterized and compare the fecal virome of two populations; healthy wild-originated captive cynomolgus macaques (n = 43) reared in NPRCT-CU and healthy wild cynomolgus macaques (n = 35). Over 90% of recognized viral sequence reads amplified fr

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6

Saito, Akatsuki, Ken Kono, Masako Nomaguchi, et al. "Geographical, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis)." Journal of General Virology 93, no. 3 (2012): 594–602. http://dx.doi.org/10.1099/vir.0.038075-0.

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The antiretroviral factor tripartite motif protein 5 (TRIM5) gene-derived isoform (TRIMCyp) has been found in at least three species of Old World monkey: rhesus (Macaca mulatta), pig-tailed (Macaca nemestrina) and cynomolgus (Macaca fascicularis) macaques. Although the frequency of TRIMCyp has been well studied in rhesus and pig-tailed macaques, the frequency and prevalence of TRIMCyp in cynomolgus macaques remain to be definitively elucidated. Here, the geographical and genetic diversity of TRIM5α/TRIMCyp in cynomolgus macaques was studied in comparison with their anti-lentiviral activity. It

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7

Huang, Shuting, Xia Huang, Shuang Li, Mingjun Zhu, and Min Zhuo. "MHC class I allele diversity in cynomolgus macaques of Vietnamese origin." PeerJ 7 (November 4, 2019): e7941. http://dx.doi.org/10.7717/peerj.7941.

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Cynomolgus macaques (Macaca fascicularis, Mafa) have been used as important experimental animal models for carrying out biomedical researches. The results of biomedical experiments strongly depend on the immunogenetic background of animals, especially on the diversity of major histocompatibility complex (MHC) alleles. However, there is much less information available on the polymorphism of MHC class I genes in cynomolgus macaques, than is currently available for humans. In this study, we have identified 40 Mafa-A and 60 Mafa-B exons 2 and 3 sequences from 30 unrelated cynomolgus macaques of Vi

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8

Reimann, Keith A., Robert A. Parker, Michael S. Seaman, et al. "Pathogenicity of Simian-Human Immunodeficiency Virus SHIV-89.6P and SIVmac Is Attenuated in Cynomolgus Macaques and Associated with Early T-Lymphocyte Responses." Journal of Virology 79, no. 14 (2005): 8878–85. http://dx.doi.org/10.1128/jvi.79.14.8878-8885.2005.

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ABSTRACT Because most studies of AIDS pathogenesis in nonhuman primates have been performed in Indian-origin rhesus macaques (Macaca mulatta), little is known about lentiviral pathogenicity and control of virus replication following infection of alternative macaque species. Here, we report the consequences of simian-human immunodeficiency virus SHIV-89.6P and SIVmac251 infection in cynomolgus (Macaca fascicularis) and rhesus macaques of Chinese origin. Compared to the pathogenicity of the same viruses in Indian rhesus macaques, both cynomolgus and Chinese rhesus macaques showed lower levels of

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9

Graham, V. A., G. J. Hatch, K. R. Bewley, et al. "Efficacy of Primate Humoral Passive Transfer in a Murine Model of Pneumonic Plague Is Mouse Strain-Dependent." Journal of Immunology Research 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/807564.

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New vaccines against biodefense-related and emerging pathogens are being prepared for licensure using the US Federal Drug Administration’s “Animal Rule.” This allows licensure of drugs and vaccines using protection data generated in animal models. A new acellular plague vaccine composed of two separate recombinant proteins (rF1 and rV) has been developed and assessed for immunogenicity in humans. Using serum obtained from human volunteers immunised with various doses of this vaccine and from immunised cynomolgus macaques, we assessed the pharmacokinetic properties of human and cynomolgus macaq

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Johnston, Sara C., Keersten M. Ricks, Alexandra Jay, et al. "Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure." PLOS ONE 16, no. 2 (2021): e0246366. http://dx.doi.org/10.1371/journal.pone.0246366.

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Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to determine critical disease parameters associated with disease progression, and establish correlations between primate and human COVID-19. Respiratory abnormalities and viral shedding were noted for all anim

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11

Rowe, Thomas, Guangping Gao, Robert J. Hogan, et al. "Macaque Model for Severe Acute Respiratory Syndrome." Journal of Virology 78, no. 20 (2004): 11401–4. http://dx.doi.org/10.1128/jvi.78.20.11401-11404.2004.

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ABSTRACT Rhesus and cynomolgus macaques were challenged with 107 PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.

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12

Mariya, Sela S., Fitriya N. Dewi, Villiandra Villiandra, et al. "Isolation and Characterization of C-C Chemokine Ligand 7 (CCL7) in Cynomolgus Macaques." HAYATI Journal of Biosciences 26, no. 3 (2019): 129. http://dx.doi.org/10.4308/hjb.26.3.129.

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Cynomolgus macaques (Macaca fascicularis) are an established animal model of asthma, which exhibit different responses to allergen exposure that are clinically relevant. The chemokine ligand gene (CCL7) encodes Monocyte Chemotactic Protein-3, which has an important role in asthma pathogenesis. While CCL7 polymorphism in humans is associated with asthma phenotype, very little is known about CCL7 in nonhuman primate models of respiratory disease. The objective of this study was to isolate and characterize CCL7 gene in cynomolgus macaques of Indonesian origin. In this study, we used sequencing an

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13

Shimozawa, Nobuhiro, Naohide Ageyama, Shunya Nakayama, Hiroshi Koie, and Yasuhiro Yasutomi. "Ultrasound-guided, Transabdominal, Intrauterine Artificial Insemination for Cynomolgus Macaques (Macaca fascicularis) Based on Estimated Timing of Ovulation." Journal of the American Association for Laboratory Animal Science 60, no. 2 (2021): 125–32. http://dx.doi.org/10.30802/aalas-jaalas-20-000038.

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Intrauterine sperm injection for artificial insemination is difficult in cynomolgus macaques (Macaca fascicularis) and rhesus macaques (M. mulatta) due to the complex structure of the cervical canal, which differs from that of humans. Despite the availability of several artificial insemination methods for macaques, pregnancy rates are inconsistent, and details regarding ovulation are unclear, thus warranting more effective methods. Therefore, we developed an effective, ultrasound-guided, transabdominal intrauterine artificial insemination method for cynomolgus macaques that involves timing spe

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14

Wiseman, Roger W., Jason A. Wojcechowskyj, Justin M. Greene, et al. "Simian Immunodeficiency Virus SIVmac239 Infection of Major Histocompatibility Complex-Identical Cynomolgus Macaques from Mauritius." Journal of Virology 81, no. 1 (2006): 349–61. http://dx.doi.org/10.1128/jvi.01841-06.

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ABSTRACT Nonhuman primates are widely used to study correlates of protective immunity in AIDS research. Successful cellular immune responses have been difficult to identify because heterogeneity within macaque major histocompatibility complex (MHC) genes results in quantitative and qualitative differences in immune responses. Here we use microsatellite analysis to show that simian immunodeficiency virus (SIV)-susceptible cynomolgus macaques (Macaca fascicularis) from the Indian Ocean island of Mauritius have extremely simple MHC genetics, with six common haplotypes accounting for two-thirds of

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15

Mellors, Theodore R., Lionel Blanchet, JoAnne L. Flynn, et al. "A new method to evaluate macaque health using exhaled breath: A case study of M. tuberculosis in a BSL-3 setting." Journal of Applied Physiology 122, no. 3 (2017): 695–701. http://dx.doi.org/10.1152/japplphysiol.00888.2016.

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Breath is hypothesized to contain clinically relevant information, useful for the diagnosis and monitoring of disease, as well as understanding underlying pathogenesis. Nonhuman primates, such as the cynomolgus macaque, serve as an important model for the study of human disease, including over 70 different human infections. In this feasibility study, exhaled breath was successfully collected in less than 5 min under Biosafety Level 3 conditions from five anesthetized, intubated cynomolgus and rhesus macaques, before and after lung infection with M. tuberculosis. The breath was subsequently ana

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16

Frick, Ondraya M., Virginia A. Livingston, Chris A. Whitehouse, et al. "The Natural History of Aerosolized Francisella tularensis Infection in Cynomolgus Macaques." Pathogens 10, no. 5 (2021): 597. http://dx.doi.org/10.3390/pathogens10050597.

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Tularemia is a severe, zoonotic infection caused by the Gram-negative bacterium Francisella tularensis. Inhalation results in a rapid, severe bacterial pneumonia and sepsis, which can be lethal. Because the cynomolgus macaque is the accepted nonhuman primate model for tularemia, we conducted a natural history study of pneumonic tularemia by exposing macaques to target inhaled doses of 50, 500, or 5000 colony forming units (CFU) of F. tularensis subsp. tularensis SCHU S4. Two animals within the 50 CFU group (calculated doses of 10 and 11 CFU) survived the challenge, while the remainder succumbe

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17

Warren, Richard, Hank Lockman, Roy Barnewall, et al. "Cynomolgus macaque model for pneumonic plague." Microbial Pathogenesis 50, no. 1 (2011): 12–22. http://dx.doi.org/10.1016/j.micpath.2010.10.002.

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18

Iverson, William O., Subramanya Karanth, Angela Wilcox, Cau D. Pham, Shawn R. Lockhart, and Simone M. Nicholson. "Talaromycosis (Penicilliosis) in a Cynomolgus Macaque." Veterinary Pathology 55, no. 4 (2018): 591–94. http://dx.doi.org/10.1177/0300985818758468.

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A sexually mature Chinese-origin female Macaca fascicularis assigned to the high-dose group in a 26-week toxicology study with an experimental immunomodulatory therapeutic antibody (a CD40 L antagonist fusion protein) was euthanized at the scheduled terminal sacrifice on study day 192. The animal was healthy at study initiation and remained clinically normal throughout the study. On study day 141, abnormal clinical pathology changes were found during a scheduled evaluation; splenomegaly was detected on study day 149 and supported by ultrasound examination. At the scheduled necropsy, there was

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19

Ambagala, Aruna P., Angie K. Marsh, Jacqueline K. Chan, et al. "Establishment of an immortal cynomolgus macaque fibroblast cell line for propagation of cynomolgus macaque cytomegalovirus (CyCMV)." Archives of Virology 158, no. 5 (2012): 955–65. http://dx.doi.org/10.1007/s00705-012-1568-4.

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20

Peña, Juliet C., and Wen-Zhe Ho. "Monkey Models of Tuberculosis: Lessons Learned." Infection and Immunity 83, no. 3 (2014): 852–62. http://dx.doi.org/10.1128/iai.02850-14.

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The use of animal models has been invaluable for studying the pathogenesis ofMycobacterium tuberculosisinfection, as well as for testing the efficacy of vaccines and drug regimens for tuberculosis. Among the applied animal models, nonhuman primates, particularly macaques, share the greatest anatomical and physiological similarities with humans. As such, macaque models have been used for investigating tuberculosis pathogenesis and preclinical testing of drugs and vaccines. This review focuses on published major studies which illustrate how the rhesus and cynomolgus macaques have enriched and ma

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21

Matsumoto, Jun, Satoru Kawai, Keiji Terao, et al. "Malaria Infection Induces Rapid Elevation of the Soluble Fas Ligand Level in Serum and Subsequent T Lymphocytopenia: Possible Factors Responsible for the Differences in Susceptibility of Two Species of Macaca Monkeys to Plasmodium coatneyi Infection." Infection and Immunity 68, no. 3 (2000): 1183–88. http://dx.doi.org/10.1128/iai.68.3.1183-1188.2000.

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ABSTRACT The intraerythrocytic stage of the simian malaria parasitePlasmodium coatneyi (CDC strain) was intravenously inoculated into two species of macaques with different susceptibilities to infection with this parasite, including four Japanese macaques (Macaca fuscata) and three cynomolgus macaques (M. fascicularis). The Japanese macaques infected with P. coatneyi developed severe clinical manifestations similar to those of severe human malaria and eventually became moribund, while the infected cynomolgus macaques, natural hosts of the parasite, exhibited no severe manifestation of disease

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22

Ee Uli, Joey, Christina Seok Yien Yong, Swee Keong Yeap, et al. "RNA sequencing (RNA-Seq) of lymph node, spleen, and thymus transcriptome from wild Peninsular Malaysian cynomolgus macaque (Macaca fascicularis)." PeerJ 5 (August 17, 2017): e3566. http://dx.doi.org/10.7717/peerj.3566.

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The cynomolgus macaque (Macaca fascicularis) is an extensively utilised nonhuman primate model for biomedical research due to its biological, behavioural, and genetic similarities to humans. Genomic information of cynomolgus macaque is vital for research in various fields; however, there is presently a shortage of genomic information on the Malaysian cynomolgus macaque. This study aimed to sequence, assemble, annotate, and profile the Peninsular Malaysian cynomolgus macaque transcriptome derived from three tissues (lymph node, spleen, and thymus) using RNA sequencing (RNA-Seq) technology. A to

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23

Shi, Qiaoli, Mingyan Ju, Xiaoxia Zhu, et al. "Pharmacokinetic Properties of Arsenic Species after Intravenous and Intragastrical Administration of Arsenic Trioxide Solution in Cynomolgus Macaques Using HPLC-ICP-MS." Molecules 24, no. 2 (2019): 241. http://dx.doi.org/10.3390/molecules24020241.

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A rapid and sensitive method was established for arsenic (As) speciation based on high performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC-ICP-MS). This method was validated for the quantification of four arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) in cynomolgus macaque plasma. Separation was achieved in just 3.7 min with an alkyl reverse phase column and highly aqueous mobile phase containing 20 mM citric acid and 5 mM sodium hexanesulfonate (pH = 4.3). The calibration cu

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24

Marsh, Angie K., Aruna P. Ambagala, Catia T. Perciani, et al. "Examining the Species-Specificity of Rhesus Macaque Cytomegalovirus (RhCMV) in Cynomolgus Macaques." PLOS ONE 10, no. 3 (2015): e0121339. http://dx.doi.org/10.1371/journal.pone.0121339.

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25

Hendrickx, A. G., N. Makori, and P. Peterson. "Nonhuman primates: their role in assessing developmental effects of immunomodulatory agents." Human & Experimental Toxicology 19, no. 4 (2000): 219–25. http://dx.doi.org/10.1191/096032700678815756.

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There are close physiologic similarities between humans and macaques that make them well suited for preclinical testing of biopharmaceutics. These include menstrual cycles of similar length and hormonal control, comparable cellular and endocrine processes of implantation, and similar time-tables of prenatal development. Three teratogenic agents have induced abnormal development of the macaque thymus that is a key organ in the development of the fetal immune system. Embryonic exposure to triamcinolone acetonide, a potent corticosteroid, during critical periods of thymus development caused marke

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26

El Mubarak, H. Sittana, Selma Yüksel, Geert van Amerongen, et al. "Infection of cynomolgus macaques (Macaca fascicularis) and rhesus macaques (Macaca mulatta) with different wild-type measles viruses." Journal of General Virology 88, no. 7 (2007): 2028–34. http://dx.doi.org/10.1099/vir.0.82804-0.

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Both rhesus and cynomolgus macaques have been used as animal models for measles vaccination and immunopathogenesis studies. A number of studies have suggested that experimental measles virus (MV) infection induces more-characteristic clinical features in rhesus than in cynomolgus monkeys. In the present study, both macaque species were infected with two different wild-type MV strains and clinical, virological and immunological parameters were compared. The viruses used were a genotype C2 virus isolated in The Netherlands in 1991 (MV-Bil) and a genotype B3 virus isolated from a severe measles c

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27

Buse, Eberhard, Martina Zöller, and Eric Van Esch. "The Macaque Ovary, with Special Reference to the Cynomolgus Macaque (Macaca fascicularis)." Toxicologic Pathology 36, no. 7_suppl (2008): 24S—66S. http://dx.doi.org/10.1177/0192623308327407.

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Smith, Alvin L., Marisa St Claire, Srikanth Yellayi, et al. "Intrabronchial inoculation of cynomolgus macaques with cowpox virus." Journal of General Virology 93, no. 1 (2012): 159–64. http://dx.doi.org/10.1099/vir.0.036905-0.

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The public health threat of orthopoxviruses from bioterrorist attacks has prompted researchers to develop suitable animal models for increasing our understanding of viral pathogenesis and evaluation of medical countermeasures (MCMs) in compliance with the FDA Animal Efficacy Rule. We present an accessible intrabronchial cowpox virus (CPXV) model that can be evaluated under biosafety level-2 laboratory conditions. In this dose-ranging study, utilizing cynomolgus macaques, signs of typical orthopoxvirus disease were observed with the lymphoid organs, liver, skin (generally mild) and respiratory

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29

Sawada, Kazuhiko. "Cerebral Sulcal Asymmetry in Macaque Monkeys." Symmetry 12, no. 9 (2020): 1509. http://dx.doi.org/10.3390/sym12091509.

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The asymmetry of the cerebral sulcal morphology is particularly obvious in higher primates. The sulcal asymmetry in macaque monkeys, a genus of the Old World monkeys, in our previous studies and others is summarized, and its evolutionary significance is speculated. Cynomolgus macaques displayed fetal sulcation and gyration symmetrically, and the sulcal asymmetry appeared after adolescence. Population-level rightward asymmetry was revealed in the length of arcuate sulcus (ars) and the surface area of superior temporal sulcus (sts) in adult macaques. When compared to other nonhuman primates, the

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Lacadena Calero, Juan Ramón. "BIOÉTIC AS MACAQUE-HUMAN CHIMERAS: SCIENTIFIC ASPECTS AND BIOETHICAL REFLECTIONS." Anales de la Real Academia Nacional de Farmacia, no. 87(02) (2021): 117–21. http://dx.doi.org/10.53519/anaesranf.2021.87.02.01.

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The obtention by Izpisua and collaborators (2021) of macaque-human chimeric embryos by microinjection of human pluripotent stem cells into early blastocysts of cynomolgus monkey is described. They studied the competency of human pluripotent stem cells in macaque embryos cultured ex vivo until 19 days post-fertilization. A reflection on these experiments is made from the bioethical point of view.

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Balamayooran, Gayathriy, Hannah M. Atkins, Christopher T. Whitlow, et al. "Labyrinthitis Ossificans in a Cynomolgus Macaque (Macaca fascicularis)." Comparative Medicine 68, no. 3 (2018): 239–42. http://dx.doi.org/10.30802/aalas-cm-17-000070.

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Bright, Lauren A., Kristin L. Gardiner, Christin L. Veeder, and Angela K. Brice. "Hepatic Hemangiosarcoma in a Cynomolgus Macaque (Macaca fascicularis)." Comparative Medicine 69, no. 3 (2019): 240–48. http://dx.doi.org/10.30802/aalas-cm-18-000130.

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Kamperschroer, Cris, Mark M. Gosink, Steven W. Kumpf, Lynn M. O’Donnell, and Karrie R. Tartaro. "The genomic sequence of lymphocryptovirus from cynomolgus macaque." Virology 488 (January 2016): 28–36. http://dx.doi.org/10.1016/j.virol.2015.10.025.

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34

Yamauchi, H., Y. Takai, H. Yamasaki, and R. Fukuda. "Thoracic Mass in a Cynomolgus Macaque (Macaca fascicularis)." Veterinary Pathology 48, no. 4 (2010): E1—E5. http://dx.doi.org/10.1177/0300985810384408.

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Villano, Jason So, Bryan Ogden, Angela Goh, Lai Siang Hui, and Pierce K. H. Chow. "Cerebellar abscess in a cynomolgus macaque (Macaca fascicularis)." Journal of Medical Primatology 37 (February 2008): 82–87. http://dx.doi.org/10.1111/j.1600-0684.2007.00254.x.

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Bergin, Ingrid L., Brandy Campbell, and Dalen W. Agnew. "Ependymal cyst in a cynomolgus macaque (Macaca fascicularis)." Journal of Medical Primatology 37, no. 5 (2008): 239–44. http://dx.doi.org/10.1111/j.1600-0684.2008.00286.x.

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Porter, B. F., P. Frost, and G. B. Hubbard. "Polyarteritis Nodosa in a Cynomolgus Macaque (Macaca fascicularis)." Veterinary Pathology 40, no. 5 (2003): 570–73. http://dx.doi.org/10.1354/vp.40-5-570.

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Adachi, K., T. Mori, T. Ito, et al. "Collagenofibrotic Glomerulonephropathy in a Cynomolgus Macaque (Macaca fascicularis)." Veterinary Pathology 42, no. 5 (2005): 669–74. http://dx.doi.org/10.1354/vp.42-5-669.

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Collagenofibrotic glomerulonephropathy (CFGN) is characterized by the deposition of type III collagen within the mesangial matrix and the absence of mesangial cell proliferation. A case of CFGN in a 2.7-year-old female cynomolgus macaque was investigated in the present study. Clinically, the animal was shown to have severe systemic edema along with hypoproteinemia. At necropsy, the kidneys were swollen and pale. The glomerular lesions were characterized by massive diffuse and global accumulation of fibrous materials in the mesangial areas. Neither mesangial cell proliferation nor changes in ot

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Uno, Yasuhiro, and Hiroshi Yamazaki. "Expression of cytochrome P450 regulators in cynomolgus macaque." Xenobiotica 48, no. 7 (2017): 695–703. http://dx.doi.org/10.1080/00498254.2017.1363928.

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Marsh, A. K., D. O. Willer, A. P. N. Ambagala, et al. "Genomic Sequencing and Characterization of Cynomolgus Macaque Cytomegalovirus." Journal of Virology 85, no. 24 (2011): 12995–3009. http://dx.doi.org/10.1128/jvi.05840-11.

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FERNANDEZ-DONOSO, R., J. LINDSTEN, and E. NORRBY. "The chromosomes of the Cynomolgus macaque (Macaca fascicularis)." Hereditas 65, no. 2 (2009): 269–75. http://dx.doi.org/10.1111/j.1601-5223.1970.tb02325.x.

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Uno, Yasuhiro, Akinori Matsushita, Norie Murayama, and Hiroshi Yamazaki. "Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9." Drug Metabolism and Pharmacokinetics 30, no. 1 (2015): 130–32. http://dx.doi.org/10.1016/j.dmpk.2014.10.002.

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Bauchet, A. L., C. Joubert, J. M. Helies, et al. "Disseminated Sparganosis in a Cynomolgus Macaque (Macaca fascicularis)." Journal of Comparative Pathology 148, no. 4 (2013): 294–97. http://dx.doi.org/10.1016/j.jcpa.2012.08.003.

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Cliett, Melissa L., and Laike St A. Stewart. "Epistaxis and nasal swelling in a cynomolgus macaque." Lab Animal 39, no. 10 (2010): 300–301. http://dx.doi.org/10.1038/laban1010-300.

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Healey, John F., Ernest Parker, and John (Pete) S. Lollar. "Comparative Decay Rates of Human, Rhesus Macaque, Cynomolgus, and Porcine Activated Factor VIII." Blood 114, no. 22 (2009): 3164. http://dx.doi.org/10.1182/blood.v114.22.3164.3164.

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Abstract Abstract 3164 Poster Board III-104 The proteolytic conversation by thrombin of factor VIII (fVIII) to fVIIIa produces a A1/A2/A3-C1-C2 heterotrimer that spontaneously dissociates into inactive A1/A3-C1-C2 and A2 species. Human mutations that increase the rate of A2 subunit dissociation produce hemophilia A, indicating that A2 subunit dissociation is physiologically relevant and is an important regulatory feature of the blood coagulation mechanism. The A2 subunit dissociation rate from human fVIIIa is significantly faster than the corresponding dissociation rates from porcine or murine

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Kaul, Artur, Uwe Schönmann, and Stefan Pöhlmann. "Seroprevalence of viral infections in captive rhesus and cynomolgus macaques." Primate Biology 6, no. 1 (2019): 1–6. http://dx.doi.org/10.5194/pb-6-1-2019.

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Abstract. Macaques serve as important animal models for biomedical research. Viral infection of macaques can compromise animal health as well as the results of biomedical research, and infected animals constitute an occupational health risk. Therefore, monitoring macaque colonies for viral infection is an important task. We used a commercial chip-based assay to analyze sera of 231 macaques for the presence of antibody responses against nine animal and human viruses. We report high seroprevalence of cytomegalovirus (CMV), lymphocryptovirus (LCV), rhesus rhadinovirus (RRV) and simian foamy virus

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Moon, Robert W., Hazem Sharaf, Claire H. Hastings, et al. "Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi." Proceedings of the National Academy of Sciences 113, no. 26 (2016): 7231–36. http://dx.doi.org/10.1073/pnas.1522469113.

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The dominant cause of malaria in Malaysia is now Plasmodium knowlesi, a zoonotic parasite of cynomolgus macaque monkeys found throughout South East Asia. Comparative genomic analysis of parasites adapted to in vitro growth in either cynomolgus or human RBCs identified a genomic deletion that includes the gene encoding normocyte-binding protein Xa (NBPXa) in parasites growing in cynomolgus RBCs but not in human RBCs. Experimental deletion of the NBPXa gene in parasites adapted to growth in human RBCs (which retain the ability to grow in cynomolgus RBCs) restricted them to cynomolgus RBCs, demon

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Hirano, Makoto, Shin Nakamura, Fusako Mitsunaga, Maki Okada, Shuya Shirahama, and Richard Eberle. "One-Step PCR To Distinguish B Virus from Related Primate Alphaherpesviruses." Clinical and Vaccine Immunology 9, no. 3 (2002): 716–19. http://dx.doi.org/10.1128/cdli.9.3.716-719.2002.

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ABSTRACT By adding betaine to the PCR mixture, we previously established a PCR method to amplify a DNA segment of the glycoprotein G gene of B virus (BV) derived from a rhesus macaque. We have found that DNA of other BV strains derived from cynomolgus, pigtail, and lion-tailed macaques can also serve as the template in our PCR assay. Under the same conditions no product was obtained with DNA of simian agent 8 of green monkeys and Herpesvirus papio 2 of baboons, or the human herpes simplex viruses types 1 and 2. Thus, this PCR method is useful to discriminate BV from other closely related prima

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Stittelaar, Koert J., Geert van Amerongen, Ivanela Kondova, et al. "Modified Vaccinia Virus Ankara Protects Macaques against Respiratory Challenge with Monkeypox Virus." Journal of Virology 79, no. 12 (2005): 7845–51. http://dx.doi.org/10.1128/jvi.79.12.7845-7851.2005.

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ABSTRACT The use of classical smallpox vaccines based on vaccinia virus (VV) is associated with severe complications in both naïve and immune individuals. Modified vaccinia virus Ankara (MVA), a highly attenuated replication-deficient strain of VV, has been proven to be safe in humans and immunocompromised animals, and its efficacy against smallpox is currently being addressed. Here we directly compare the efficacies of MVA alone and in combination with classical VV-based vaccines in a cynomolgus macaque monkeypox model. The MVA-based smallpox vaccine protected macaques against a lethal respi

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Haddock, Elaine, Friederike Feldmann, David W. Hawman, et al. "A cynomolgus macaque model for Crimean–Congo haemorrhagic fever." Nature Microbiology 3, no. 5 (2018): 556–62. http://dx.doi.org/10.1038/s41564-018-0141-7.

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