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Relevant bibliographies by topics / CYP27A1

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Academic literature on the topic 'CYP27A1'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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Journal articles on the topic "CYP27A1"

1

Sawada, Natsumi, Toshiyuki Sakaki, Sachiko Kitanaka, Shigeaki Kato, and Kuniyo Inouye. "Structure-function analysis of CYP27B1 and CYP27A1." European Journal of Biochemistry 268, no. 24 (2001): 6607–15. http://dx.doi.org/10.1046/j.0014-2956.2001.02615.x.

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Nemazannikova, Natalie, Gregory L. Blatch, Crispin R. Dass, Rodney Sinclair, and Vasso Apostolopoulos. "Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer." Acta Biochimica et Biophysica Sinica 51, no. 4 (2019): 444–47. http://dx.doi.org/10.1093/abbs/gmy170.

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Abouzid, Mohamed, Łukasz Kruszyna, Dominika Kaczmarek, et al. "Genetic Polymorphism of CYP2R1, CYP27A1, CYP27B1, and Vitamin D Metabolites Plasma Levels in Patients with Cardiovascular Disease: A Pilot Study." Biomolecules 15, no. 5 (2025): 699. https://doi.org/10.3390/biom15050699.

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The active form of vitamin D, calcitriol (1,25(OH)2D3), is produced from 25(OH)D3 via enzymes encoded by CYP2R1, CYP27A1, and CYP27B1. Polymorphisms in these genes may alter vitamin D metabolism and increase cardiovascular disease risk. This preliminary study investigated these polymorphisms in 27 patients with cardiovascular disease and 26 healthy volunteers using Polymerase Chain Reaction—Restriction Fragment Length Polymorphism (PCR-RFLP), while measuring 25(OH)D3 and 1,25(OH)2D3 concentrations by UPLC-MS/MS and ELISA, respectively. Among patients, those with the GT genotype of rs10877012 (

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Mazanova, Anna, Ihor Shymanskyi, Olha Lisakovska, Lala Hajiyeva, Yulia Komisarenko, and Mykola Veliky. "Effects of Cholecalciferol on Key Components of Vitamin D-Endo/Para/Autocrine System in Experimental Type 1 Diabetes." International Journal of Endocrinology 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/2494016.

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Objectives.Recent prospective studies have found the associations between type 1 diabetes (T1D) and vitamin D deficiency. We investigated the role of vitamin D in the regulation of 25OHD-1α-hydroxylase (CYP27B1) and VDR expression in different tissues of T1D rats.Design.T1D was induced in male Wistar rats by streptozotocin (55 mg/k b.w.). After 2 weeks of T1D, the animals were treated orally with or without vitamin D3(cholecalciferol; 100 IU/rat, 30 days).Methods.Serum 25-hydroxyvitamin D (25OHD) was detected by ELISA. CYP27A1, CYP2R1, CYP27B1, and VDR were assayed by RT-qPCR and Western blott

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Hasan, Maruf, Michael Oster, Henry Reyer, et al. "Tissue-Wide Expression of Genes Related to Vitamin D Metabolism and FGF23 Signaling following Variable Phosphorus Intake in Pigs." Metabolites 12, no. 8 (2022): 729. http://dx.doi.org/10.3390/metabo12080729.

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Calcium (Ca) and phosphorus (P) homeostasis is maintained by several regulators, including vitamin D and fibroblast growth factor 23 (FGF23), and their tissue-specific activation and signaling cascades. In this study, the tissue-wide expression of key genes linked to vitamin D metabolism (CYP2R1, CYP27A1, CYP27B1, CYP24A1, GC, VDR) and FGF23 signaling (FGF23, FGFR1-4, KL) were investigated in pigs fed conventional (trial 1) and divergent P diets (trial 2). The tissue set comprised kidney, liver, bone, lung, aorta, and gastrointestinal tract sections. Expression patterns revealed that non-renal

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Cheng, Kai-Hung, Edward Hsi, Chia-Chu Liu, et al. "The Associations of Novel Vitamin D3Metabolic GeneCYP27A1Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males." International Journal of Endocrinology 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/658151.

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Metabolic syndrome (MetS) confers increased risks of cardiovascular disease (CVD). Both vitamin D3and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS. In vitamin D3metabolism, the vitamin D325-hydroxylase (CYP27A1) and 25-hydroxyvitamin D31-alpha-hydroxylase (CYP27B1) are two key enzymes. This study aimed to examine the influence of vitamin D3CYP27 single nucleotide polymorphisms (SNPs) on adipocytokines and MetS. Cross-sectional data and DNA samples were collected from male volunteers (n=649, age: 55.7 ± 4.7 years). Two tagging SNPs,CYP27A1 rs4674344andC

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Törzsök, Peter, Jasper Van Goubergen, Martin Pichler, Renate Pichler, and Frédéric R. Santer. "Isochromosome 12p Formation Regulates Vitamin D Metabolism in Testicular Cancer." Nutrients 15, no. 10 (2023): 2384. http://dx.doi.org/10.3390/nu15102384.

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Isochromosome 12p (iChr12p) is typical in almost all invasive testicular cancers. Increased copy number of genes on 12p is associated with the development of a clinically manifest tumor; however, the causative genes have not yet been identified. Chromosome 12 harbors many genes involved in Vitamin D metabolism. RNAseq analysis of Vitamin D receptor (VDR) genes from the TCGA cohort revealed that clustering of VDR expression signatures could differentiate between pure seminomas and non-seminomatous germ cell tumors (NSGCT). Using TCGA mRNA expression of anabolic (CYP2R1, CYP27A1 and CYP27B1) and

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QUINN, Carmel M., Wendy JESSUP, Jenny WONG, Leonard KRITHARIDES та Andrew J. BROWN. "Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARγ ligands". Biochemical Journal 385, № 3 (2005): 823–30. http://dx.doi.org/10.1042/bj20041776.

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CYP27A1 (sterol 27-hydroxylase) catalyses an important sterol elimination pathway in the human macrophage, and consequently may protect against atherosclerosis. We studied the expression and regulation of CYP27A1 in a human macrophage-like cell-line, THP-1, and primary HMDMs (human monocyte-derived macrophages). In both macrophage cell types, we found that CYP27A1 expression is independent of cellular cholesterol levels and of LXR (liver X receptor)-dependent control of transcription. However, the RXR (retinoid X receptor) ligand, 9-cis-retinoic acid, upregulates CYP27A1 expression. Of the RXR

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Petrov, Alexey M., Artem A. Astafev, Natalia Mast, Aicha Saadane, Nicole El-Darzi, and Irina A. Pikuleva. "The Interplay between Retinal Pathways of Cholesterol Output and Its Effects on Mouse Retina." Biomolecules 9, no. 12 (2019): 867. http://dx.doi.org/10.3390/biom9120867.

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In mammalian retina, cholesterol excess is mainly metabolized to oxysterols by cytochromes P450 27A1 (CYP27A1) and 46A1 (CYP46A1) or removed on lipoprotein particles containing apolipoprotein E (APOE). In contrast, esterification by sterol-O-acyltransferase 1 (SOAT) plays only a minor role in this process. Accordingly, retinal cholesterol levels are unchanged in Soat1−/− mice but are increased in Cyp27a1−/−Cyp46a1−/− and Apoe−/− mice. Herein, we characterized Cyp27a1−/−Cyp46a1−/−Soat1−/− and Cyp27a1−/−Cyp46a1−/−Apoe−/− mice. In the former, retinal cholesterol levels, anatomical gross structure

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Escher, Geneviève, Isabelle Vögeli, Robert Escher, et al. "Role of CYP27A1 in progesterone metabolism in vitro and in vivo." American Journal of Physiology-Endocrinology and Metabolism 297, no. 4 (2009): E949—E955. http://dx.doi.org/10.1152/ajpendo.00298.2009.

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In the kidney, progesterone is inactivated to 20α-dihydro-progesterone (20α-DH-progesterone) to protect the mineralocorticoid receptor from progesterone excess. In an attempt to clone the enzyme with 20α-hydroxysteroid activity using expression cloning in CHOP cells and a human kidney expression library, serendipitously cDNA encoding CYP27A1 was isolated. Overexpression of CYP27A1 in CHOP cells decreased progesterone conversion to 20α-DH-progesterone in a dose-dependent manner, an effect enhanced by cotransfection with adrenodoxin and adrenodoxin reductase. Incubation of CHOP cells with 27-hyd

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Dissertations / Theses on the topic "CYP27A1"

1

Bahr, Sara von. "Studies on sterol 27-hydroxylase (CYP27A1) /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-824-6/.

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Tang, Wanjin. "Hormonal Regulation of the Human CYP27A1 and CYP7B1 Genes." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7837.

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Reijntjes, Susan Joanne. "The regulation of retinoic acid signalling by CYP26A1, CYP26B1 and CYP26C1 in the developing embryo." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429657.

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Hansson, Magnus. "Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-182-1/.

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Foti, Robert. "Caractérisation des substrats xénobiotiques et des inhibiteurs des cytochromes CYP26A1, CYP26B1 et CYP26C1 par modélisation moléculaire et études in vitro." Electronic Thesis or Diss., Nice, 2016. http://www.theses.fr/2016NICE4033.

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En l’absence de structures tridimensionnelles expérimentales des cytochromes P450 CYP26A1, CYP26B1 et CYP26C1, la caractérisation de leur substrats et ligands s’est basée sur l’analyse des modèles structuraux obtenus par modélisation par homologie avec la structure expérimentale du cytochrome P450 CYP120. La justesse des modèles a été validée par l’amarrage de l’acide rétinoïque all-trans dans des configurations compatibles avec les métabolites attendus. L’amarrage d’agonistes et d’antagonistes des récepteurs nucléaires RARs prédirent l’acide tazaroténique (TA) et l’adapalène comme des substra

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Foti, Robert. "Caractérisation des substrats xénobiotiques et des inhibiteurs des cytochromes CYP26A1, CYP26B1 et CYP26C1 par modélisation moléculaire et études in vitro." Thesis, Nice, 2016. http://www.theses.fr/2016NICE4033/document.

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En l’absence de structures tridimensionnelles expérimentales des cytochromes P450 CYP26A1, CYP26B1 et CYP26C1, la caractérisation de leur substrats et ligands s’est basée sur l’analyse des modèles structuraux obtenus par modélisation par homologie avec la structure expérimentale du cytochrome P450 CYP120. La justesse des modèles a été validée par l’amarrage de l’acide rétinoïque all-trans dans des configurations compatibles avec les métabolites attendus. L’amarrage d’agonistes et d’antagonistes des récepteurs nucléaires RARs prédirent l’acide tazaroténique (TA) et l’adapalène comme des substra

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Ellfolk, Maria. "Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D." Doctoral thesis, Uppsala universitet, Avdelningen för farmaceutisk biokemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9412.

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A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. A CYP2D25 promoter-luciferase reporter plasmid was constructed in order to study the transcriptional regulation of the gene. Treatment with the vitamin D metabolites calcidiol and calcitriol suppressed the promoter, provided that the nuclear receptors VDR and RXR were overexpressed. Phenobarbital was also capable of suppressing the promoter if th

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Goncalves, Renata. "Interactions entre la signalisation estrogénique et la vitamine D dans les cellules testiculaires." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC411/document.

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La 1α,25(OH)2 vitamine D3 (1,25-D3) est synthétisée à partir du cholestérol par l'exposition solaire de la peau. Les effets de cette hormone sont médiées par le récepteur de la vitamine D (VDR) dans le noyau et à la membrane plasmique, et avec le récepteur PDIA3 ils médient des effets génomiques et non-génomique. La vitamine D joue un rôle important dans la reproduction, puisque la réduction de la fertilité a été observée chez les rats déficients en vitamine D. L'estradiol (E2) est synthétisé à partir de la testostérone par l'enzyme aromatase (CYP19). L’E2 a des effets génomiques et non génomi

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Aatsinki, S. M. (Sanna-Mari). "Regulation of hepatic glucose homeostasis and Cytochrome P450 enzymes by energy-sensing coactivator PGC-1α". Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526208053.

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Abstract Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a master regulator of energy metabolism and mitochondrial biology in high-energy cell types and tissues. The regulation of PGC-1α is versatile, and both transcriptional and post-transcriptional mechanisms play major roles. External stimuli affect PGC-1α-regulation which in turn adapts cellular signals to meet them. For example, conditions like fasting and diabetes mellitus (DM) are known to activate PGC-1α expression in the liver, resulting in enhanced de novo glucose production, gluconeogenesis. In the present st

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Wang, Jue. "Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-650-6/.

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Books on the topic "CYP27A1"

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Goodz, Shari D. Investigating aspects of CYP2A6 in Caucasian and African American smokers. National Library of Canada, 2002.

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Zeman, Marilyn Vera. evaluation of coumarin as an in vivo measure of CYP2A6 activity. National Library of Canada, 1998.

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3

Pelkonen, Päivi. Involvement of Hamster CYP2A enzymes in the bioactivation of chemical carcinogens. University of Kuopio, 1995.

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Dortok, E. Desiree. Analysis of the possible therapeutic use of CYP2A6 inhibition with methoxsalen in smoking cessation. National Library of Canada, 2001.

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Nowak, Maciej P. Comparison of polymorphic CYP2D6, CYP2C19 and CYP2A6 in Canadian Native Indian, Caucasian and Chinese populations. National Library of Canada = Bibliothèque nationale du Canada, 1999.

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Micu, Alina L. An investigation of the induction of hepatic CYP2E1 by low doses of nicotine in the rat. National Library of Canada, 2003.

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7

Berns, Trevor Aaron. The influence of CYP2D1 in the behavioural pharmacology of amphetamine and hydrocodone in the male wistar rat. National Library of Canada, 1995.

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Lekas, Poli. Analysis of human CYP2E1 mRNA in a HepG2 cell line by reverse transcription-polymerase chain reaction (RT-PCR). National Library of Canada, 1998.

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9

Verrips, Aad. Cerebrotendinous Xanthomatosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0040.

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Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disease due to a defect in bile acid metabolism. Worldwide, more than 300 patients have been described. Mutations in the CYP27A1 gene result in sterol 27-hydroxylase deficiency leading to the accumulation of cholestanol in multiple body tissues. Premature cataracts, chronic diarrhea, tendon xanthomas, and neurological deterioration are the predominant clinical features. There are several disease stages, from being nearly asymptomatic in the early childhood years to severe disability in later stages of life. Adult CTX patients a

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Howard, Lisa Angela. Alcohol, nicotine and genetic variation influence CYP2E1. 2003.

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Book chapters on the topic "CYP27A1"

1

Lee, Hsien-Hsiung. "Mutational Analysis of CYP21A2 Gene and CYP21A1P Pseudogene: Long-range PCR on Genomic DNA." In Methods in Molecular Biology. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0835-6_19.

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Gmelch, Benjamin S., and Randal O. Dull. "CYP2E1: The Anesthesia Enzyme." In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-7495-1_6.

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Çeven, Fatma Nur, and Idris Arslan. "Oncogenic Potential of CYP24A1: Implications for Cancer Diagnosis and Treatment." In Lecture Notes in Networks and Systems. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-95200-5_31.

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Raunio, Hannu, Jukka Hakkola, and Olavi Pelkonen. "Chapter 5. The CYP2A Subfamily." In Issues in Toxicology. Royal Society of Chemistry, 2008. http://dx.doi.org/10.1039/9781847558428-00150.

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Cederbaum, Arthur I. "Nrf2 and Antioxidant Defense Against CYP2E1 Toxicity." In Subcellular Biochemistry. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-5881-0_2.

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Kawaguchi, Hiroshi, Colm O’hUigin, and Jan Klein. "Evolution of Primate C4 and CYP21 Genes." In Molecular Evolution of the Major Histocompatibility Complex. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-84622-9_30.

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Schulz, Thomas G., Peter Ruhnau, and Ernst Hallier. "Lack of Correlation Between CYP2A6 Genotype and Smoking Habits." In Advances in Experimental Medicine and Biology. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-0667-6_29.

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Daly, Ann K. "Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease." In Subcellular Biochemistry. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-5881-0_5.

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Lakshman, M. Raj, Mamatha Garige, Maokai A. Gong, et al. "CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism." In Subcellular Biochemistry. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-5881-0_7.

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Wu, Defeng, and Arthur I. Cederbaum. "Development and Properties of HepG2 Cells That Constitutively Express CYP2E1." In Alcohol. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-242-7_11.

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Conference papers on the topic "CYP27A1"

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Muhammed, Omar, and Salwa Al-Rubae’i. "Association of CYP27A1 and CYP27B1 genes polymorphisms with multiple sclerosis in Iraqi patients." In PROCEEDING OF THE 1ST INTERNATIONAL CONFERENCE ON ADVANCED RESEARCH IN PURE AND APPLIED SCIENCE (ICARPAS2021): Third Annual Conference of Al-Muthanna University/College of Science. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0094461.

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Costa, Gustavo Carvalho, Carolina Maria Marin, Igor Braga Farias, et al. "Self-mutilation as a clinical manifestation of Cerebrotendinous Xanthomatosis." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.063.

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Introduction: Cerebrotendinous xanthomatosis (CTX) is a rare neurological entity, which consists of an autosomal recessive inherited disorder of bile acid biosynthesis due to CYP27A1 variants, with variable systemic and neurological clinical presentation. Psychiatric signs are also observed at early adulthood and includes behavioral and personality changes, depression and psychosis. However, self-mutilation has not been previously described. Case report: We attend to two sisters with a unique clinical presentation. The first patient, 33 years old, presented epilepsy at 17, in addition to cogni

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He, Sisi, Amy E. Baek, Liqian Ma, Joanna Burdette, and Erik R. Nelson. "Abstract 199: Host CYP27A1 expression is essential for ovarian cancer progression." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-199.

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Kaziakhmedova, C. A., O. V. Glazova, and P. Yu Volchkov. "DETECTION OF TRANSCRIPTOMIC DIFFERENCES IN CELL POPULATIONS OF ADRENOCORTICAL CELLS IN NORMAL CONDITIONS AND IN CYP21A1 GENE MUTATIONS." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-326.

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The adrenal glands are an important endocrine organ producing corticosteroids and catecholamines. Pathologies that lead to a decrease in the endogenous production of all or some of the adrenal hormones are often caused by mutations in the genes of proteins responsible for various stages of their synthesis. One of the most common disorders of this type is congenital adrenal dysfunction (CAD) caused by mutations in the CYP21A2 (Cyp21a1) gene. In the most severe cases, the course of this disease can lead to such life-threatening conditions as an adrenal crisis. Identification of differences in th

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Going, Catherine, Ludmila Alexandrova, Ken Lau, et al. "Abstract 5635: Vitamin D supplementation decreases serum 27-hydroxycholesterol and expression of CYP27A1 in tumors of breast cancer patients." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5635.

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Inasu, Maria, Pär Ola Bendahl, Mårten Fernö, Per Malmström, Signe Borgquist, and Siker Kimbung. "Abstract P3-08-21: High CYP27A1 expression at protein and transcript level predicts favorable outcome in node negative, premenopausal breast cancer." In Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-p3-08-21.

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Khan, Nabeela A., Konrad H. Stopsack, Emma H. Allott, et al. "Abstract 1450: Intratumoral CYP27A1 expression in relation to cholesterol synthesis and vitamin D signaling and its association with lethal prostate cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1450.

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Alfaqih, Mahmoud A., Erik R. Nelson, Rachid Safi, Jeff Jasper, Donald P. McDonnell, and Stephen J. Freedland. "Abstract PR11: Dysregulation of cholesterol homeostasis through loss of CYP27A1 in prostate cancer; Implications for early detection and prevention of over-treatment." In Abstracts: Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; September 27 - October 1, 2014; New Orleans, LA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1940-6215.prev-14-pr11.

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Loo, Lenora WM, Yurii B. Shvetsov, Iona Cheng, and Brenda Y. Hernandez. "Abstract C073: The association between 27-hydroxycholesterol metabolizing enzymes, CYP27A1 and CYP7B1, expression and mortality in a multiethnic U.S. population of breast cancer patients." In Abstracts: Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; September 20-23, 2019; San Francisco, CA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp19-c073.

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Kimbung, S., T. Stålhammar, M. Inasu, et al. "Abstract P2-08-26: High expression of CYP27A1 in breast cancer is associated with poor tumor pathological features and may differentially predict prognosis depending on menopausal status." In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p2-08-26.

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Reports on the topic "CYP27A1"

1

Dudley, A., M. M. Peden-Adams, J. E. Daly, and D. E. Keil. JP-8 Jet Fuel Induces CYP2B1, CYP2BE1, and GSTPI but not CYP1A1 in Murine Liver. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada402064.

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Lawanprasert, Somsong, Chaiyo Chaichantipyuth, Supatra Srichairat, Nuansri Niwattisaiwong, and Laddawal Phivthong-ngam. Subchronic exposure of Pueraria mirifica in normal - and high cholesterol diet fed rats : influence on hepatic cytochrome P450, lipid profile and toxicity. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.28.

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Pueraria mirifica airy shaw and suvatabandhu, know locally as Kwao Keur, is a plant in family Leguminosae. In this study, effects of P.mirifica on hepatic cytochrome P450 (CYP), serum lipid profile and subchronic toxicity were investigated in male Wistar rats. Rats were randomly divided into four treatment groups as following: normal diet-fed group; normal diet-fed supplemented with P.mirifica group; high cholesterol diet-fed group; high cholesterol diet-fed supplemented with P.mirifica group. Each group comprised 10 rats. P.mirifica was administered orally at a dosage of 100 mg/kg/day for 90

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Ma, Long, Gang Jin, Yi Yang, et al. Association Between CYP2A13 Polymorphisms and Lung Cancer. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2020. http://dx.doi.org/10.37766/inplasy2020.9.0102.

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ลาวัณย์ประเสริฐ, สมทรง, พรพิมล กิจสนาโยธิน, นวลศรี นิวัติศัยวงศ์, มยุรี ตันติสิระ та ชำนาญ ภัตรพานิช. ผลของวัลโปรอิล มอร์โฟลีนต่อเอนไซม์ไซโตโครมพี 450 ในตับหนูขาว. จุฬาลงกรณ์มหาวิทยาลัย, 2001. https://doi.org/10.58837/chula.res.2001.28.

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ศึกษาผลของวัลโปรอิล มอร์โฟลีน (วีพีเอ็ม) ต่อเอนไซม์ไซโตโครม พี 450 ในตับหนูขาว โดยการฉีดวีพีเอ็ม และวัลโปรอิค แอซิค (วีพีเอ) ซึ่งเป็นสารต้นแบบของวีพีเอ็มในขนาดที่ต้านชักได้ในสัตว์ทดลองจำนวนครึ่งหนึ่ง (100 มิลลิกรัม/กิโลกรัม/วัน สำหรับวีพีเอ็ม และ 250 มิลลิกรัม/กิโลกรัม/วัน สำหรับวีพีเอ) และวีพีเอ็ม ขนาด 200 มิลลิกรัม/กิโลกรัม/วัน แก่หนูขาวเพศผู้ทางหน้าท้อง เป็นเวลา 7 วัน หลังจากนั้นฆ่าหนู แล้วเตรียมไมโครโวมจากตับ ทำการวิเคราะห์หาปริมาณไวโตโครม พี 450 รวม และแอคติวิตีของไซโตโครม พี 450 จากไมโครโซม ผลการวิจัยพบว่า ทั้งวีพีเอ็มและวีพีเอไม่มีผลเปลี่ยนแปลงค่าต่าง ๆ เหล่านี้ : ปริมาณไซโตโครม พี 450

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