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Dissertations / Theses on the topic 'CYP27A1'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

Bahr, Sara von. "Studies on sterol 27-hydroxylase (CYP27A1) /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-824-6/.

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2

Tang, Wanjin. "Hormonal Regulation of the Human CYP27A1 and CYP7B1 Genes." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7837.

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3

Reijntjes, Susan Joanne. "The regulation of retinoic acid signalling by CYP26A1, CYP26B1 and CYP26C1 in the developing embryo." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429657.

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4

Hansson, Magnus. "Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-182-1/.

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5

Foti, Robert. "Caractérisation des substrats xénobiotiques et des inhibiteurs des cytochromes CYP26A1, CYP26B1 et CYP26C1 par modélisation moléculaire et études in vitro." Electronic Thesis or Diss., Nice, 2016. http://www.theses.fr/2016NICE4033.

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En l’absence de structures tridimensionnelles expérimentales des cytochromes P450 CYP26A1, CYP26B1 et CYP26C1, la caractérisation de leur substrats et ligands s’est basée sur l’analyse des modèles structuraux obtenus par modélisation par homologie avec la structure expérimentale du cytochrome P450 CYP120. La justesse des modèles a été validée par l’amarrage de l’acide rétinoïque all-trans dans des configurations compatibles avec les métabolites attendus. L’amarrage d’agonistes et d’antagonistes des récepteurs nucléaires RARs prédirent l’acide tazaroténique (TA) et l’adapalène comme des substra

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6

Foti, Robert. "Caractérisation des substrats xénobiotiques et des inhibiteurs des cytochromes CYP26A1, CYP26B1 et CYP26C1 par modélisation moléculaire et études in vitro." Thesis, Nice, 2016. http://www.theses.fr/2016NICE4033/document.

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En l’absence de structures tridimensionnelles expérimentales des cytochromes P450 CYP26A1, CYP26B1 et CYP26C1, la caractérisation de leur substrats et ligands s’est basée sur l’analyse des modèles structuraux obtenus par modélisation par homologie avec la structure expérimentale du cytochrome P450 CYP120. La justesse des modèles a été validée par l’amarrage de l’acide rétinoïque all-trans dans des configurations compatibles avec les métabolites attendus. L’amarrage d’agonistes et d’antagonistes des récepteurs nucléaires RARs prédirent l’acide tazaroténique (TA) et l’adapalène comme des substra

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7

Ellfolk, Maria. "Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D." Doctoral thesis, Uppsala universitet, Avdelningen för farmaceutisk biokemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9412.

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A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. A CYP2D25 promoter-luciferase reporter plasmid was constructed in order to study the transcriptional regulation of the gene. Treatment with the vitamin D metabolites calcidiol and calcitriol suppressed the promoter, provided that the nuclear receptors VDR and RXR were overexpressed. Phenobarbital was also capable of suppressing the promoter if th

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8

Goncalves, Renata. "Interactions entre la signalisation estrogénique et la vitamine D dans les cellules testiculaires." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC411/document.

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La 1α,25(OH)2 vitamine D3 (1,25-D3) est synthétisée à partir du cholestérol par l'exposition solaire de la peau. Les effets de cette hormone sont médiées par le récepteur de la vitamine D (VDR) dans le noyau et à la membrane plasmique, et avec le récepteur PDIA3 ils médient des effets génomiques et non-génomique. La vitamine D joue un rôle important dans la reproduction, puisque la réduction de la fertilité a été observée chez les rats déficients en vitamine D. L'estradiol (E2) est synthétisé à partir de la testostérone par l'enzyme aromatase (CYP19). L’E2 a des effets génomiques et non génomi

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9

Aatsinki, S. M. (Sanna-Mari). "Regulation of hepatic glucose homeostasis and Cytochrome P450 enzymes by energy-sensing coactivator PGC-1α". Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526208053.

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Abstract Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a master regulator of energy metabolism and mitochondrial biology in high-energy cell types and tissues. The regulation of PGC-1α is versatile, and both transcriptional and post-transcriptional mechanisms play major roles. External stimuli affect PGC-1α-regulation which in turn adapts cellular signals to meet them. For example, conditions like fasting and diabetes mellitus (DM) are known to activate PGC-1α expression in the liver, resulting in enhanced de novo glucose production, gluconeogenesis. In the present st

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10

Wang, Jue. "Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-650-6/.

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11

Almeida, Adriana Ávila de. "Expressão dos genes CYP1A1, CYP1B1, CYP2A6 e CYP2E1 em fumantes com câncer bucal. /." São José dos Campos, 2018. http://hdl.handle.net/11449/153357.

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Orientador: Janete Dias Almeida<br>Coorientador: Celina Faig Lima Carta<br>Banca: Emília Ângela Lo Schiavo Arisawa<br>Banca: Ana Lia Anbinder<br>Banca: Alberto José de Araújo<br>Banca: José Benedito Oliveira Amorim<br>Resumo: Os carcinógenos do tabaco estão relacionados a diversos tipos de câncer incluindo o carcinoma de células escamosas (CCE) bucal. Aliado ao álcool, o tabaco contribui para o desfecho desfavorável destes casos. A susceptibilidade individual ao câncer pode estar relacionada a expressão das enzimas que metabolizam tais carcinógenos. O objetivo deste trabalho é avaliar a expres

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12

Almeida, Adriana Ávila de [UNESP]. "Expressão dos genes CYP1A1, CYP1B1, CYP2A6 e CYP2E1 em fumantes com câncer bucal." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153357.

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Submitted by Adriana Ávila de Almeida null (celdrica2003@yahoo.com.br) on 2018-03-23T16:45:45Z No. of bitstreams: 1 Tese Final - Adriana Ávila de Almeida.pdf: 2506211 bytes, checksum: e38a3f026d55d541be0fd2ec9142a2a2 (MD5)<br>Approved for entry into archive by Silvana Alvarez null (silvana@ict.unesp.br) on 2018-04-03T21:06:34Z (GMT) No. of bitstreams: 1 almeida_aa_dr.sjc.pdf: 2506211 bytes, checksum: e38a3f026d55d541be0fd2ec9142a2a2 (MD5)<br>Made available in DSpace on 2018-04-03T21:06:34Z (GMT). No. of bitstreams: 1 almeida_aa_dr.sjc.pdf: 2506211 bytes, checksum: e38a3f026d55d541be0fd2ec9

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13

Charvet, Casey Douglas. "Post-Translational Modification By Isolevuglandins: Retinal Detection, Effects, and Prevention." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1366296569.

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14

Sever, Melike. "In Vivo Effect Of Epilobium Hirsutum L. And Viscum Album L. On Protein And Mrna Expressions Of Rat Liver Vitamin D3 Metabolizing Cyp24a1 And Cyp27b1 Enzymes." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614631/index.pdf.

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Epilobium hirsutum L. (Onagraceae) is a flowering, tall and perennial plant and native to Eurasia. It shows analgesic, anti-microbial and anti-proliferative activity, and it is used in our country as an alternative medicine. The pharmacological effect of Epilobium hirsutum L. could be explained by the presence of polyphenolics including steroids, tannins and flavonoids in the aerial parts. Viscum album L. (Loranthaceae) is a shrub that grows as an epiphyte on the branches of deciduous trees. It involves in the enhancement of macrophage phagocytic and cytotoxic mediated abilities as well as the

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15

Pettersson, Hanna. "Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100787.

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Diss. (sammanfattning) Uppsala : Uppsala universitet, 2009.<br>Disputationsordförande;Professor Eva Brittebo, Inst. för Biovetenskap, Avd. för Toxikologi, Uppsala Universitet, UppsalaBetygsnämndens ledamöten; Docent Lena Ekström, Inst. för Laboratoriemedicin, Avd. för Klinisk Kemi, Karolinska Universitetssjukhuset, HuddingeDocent Ulf Diczfaluzy, Inst. för Laboratoriemedicin, Avd. för Klinisk Kemi, Karolinska Universitetssjukhuset, HuddingeProfessor Agneta Oskarsson, Inst. BVF, Avd. för farmakologi och toxikologi, SLU, Uppsala. Härtill 4 uppsatser.

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16

Nail, Alexandra Nichole. "EVOLUTION OF THE ZHX TRANSCRIPTION FACTOR FAMILY AND ANALYSIS OF ZHX2 TARGET GENES CYP2A4 AND CYP2A5 IN MOUSE LIVER." UKnowledge, 2019. https://uknowledge.uky.edu/microbio_etds/20.

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The liver is the largest internal organ and performs a wide variety of functions to maintain organismal homeostasis. While some liver functions are carried out by all hepatocytes, other functions are restricted to certain populations of hepatocytes within the liver. This phenomenon, called zonal gene regulation or liver zonation, controls may metabolic processes within the liver including ammonia detoxification; glucose homeostasis; bile acid and glutamine synthesis; and metabolism of xenobiotics, lipids, and amino acids. The liver also expresses many genes in a developmental or sex-biased man

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17

Koreng, Milena [Verfasser], and Jörg [Akademischer Betreuer] Reichrath. "Genetische Varianten des Vitamin D-Rezeptors, Vitamin D-Bindungsproteins, der CYP24A1, CYP27B1 und des Melanocortin 1-Rezeptors bei aktinischen Keratosen, kutanen Plattenepithelkarzinomen sowie Basalzellkarzinomen / Milena Koreng. Betreuer: Jörg Reichrath." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/1054055467/34.

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18

Coeli, Fernanda Borchers. "Analise molecular do loco C4/CYP21 : impacto da variabilidade alelica provocada por recombinações sobre os metodos de avaliação de mutações." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317127.

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Orientador: Maricilda Palandi de Mello<br>Tese (doutorado) - Universidade Estadual de Campinas, Insituto de Campinas<br>Made available in DSpace on 2018-08-13T00:56:19Z (GMT). No. of bitstreams: 1 Coeli_FernandaBorchers_D.pdf: 7777269 bytes, checksum: 053a66d2bc3df6ad0d5de7c2038f3246 (MD5) Previous issue date: 2009<br>Resumo: A hiperplasia congênita da adrenal é causada pela deficiência de uma das cinco enzimas responsáveis pela síntese do cortisol na esteroidogênese, sendo que mais de 90% dos casos ocorrem devido à deficiência de 21-hidroxilase (21-OH). O genoma haplóide humano possui duas

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19

Segersten, Ulrika. "Vitamin D Hydroxylating Enzymes and Analogues in Parathyroid Tumors and Breast Cancer." Doctoral thesis, Uppsala University, Department of Surgical Sciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6008.

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<p>In hyperparathyroidism (HPT) raised serum concentrations of ionized calcium is caused by increased secretion of parathyroid hormone (PTH) by parathyroid tumors. Active vitamin D, 1α,25-dihydroxyvitamin D<sub>3</sub>, is known to suppress PTH secretion and to reduce proliferation of parathyroid tumor cells.</p><p>The aim of this thesis was to examine expression of vitamin D hydroxylating enzymes, regulating the activation and inactivation of vitamin D and to study effects of vitamin D analogues, in parathyroid tumors and breast cancer.</p><p>The vitamin D activating enzyme, CYP27B1/25-hydrox

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20

Taban, Ismail. "Design and synthesis of novel CYP24A1 inhibitors." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/105297/.

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CYP24A1 (25-hydroxyvitamin D-24-hydroxylase) is a useful enzyme target for a range of medical conditions including cancer, cardiovascular and autoimmune disease, which show elevated CYP24A1 levels and corresponding reduction of calcitriol (the biologically active form of vitamin D). Calcitriol has antiproliferative and pro-differentiating properties, however use of calcitriol as a therapeutic drug is limited by hypercalcaemia. An alternative approach is the use of CYP24A1 inhibitors to prevent the metabolism of calcitriol. The aim of this research is to design and synthesise novel inhibitors o

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21

Menassa, Rita. "Études fonctionnelles et structurales des mutants du gène CYP21A2 dans l’hyperplasie congénitale des surrénales." Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10160/document.

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Le déficit en 21-hydroxylase est la cause la plus fréquente des hyperplasies congénitales des surrénales. Un grand nombre de nouvelles mutations a été trouvé dans le laboratoire qui centralise la plus grande cohorte de familles au niveau international et l’évaluation de leur sévérité était primordiale pour optimiser la prise en charge des patients (thérapeutique, conseil génétique). Grâce à l’analyse approfondie du phénotype des patients et au développement d’études fonctionnelles (in vitro, in silico), nous avons pu évaluer le retentissement de la plupart des 85 nouvelles mutations ; nous avo

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22

Langton, Simne. "The generation and characterization of CYP26A1(-/-) murine embryonic stem cells /." Access full-text from WCMC, 2007. http://proquest.umi.com/pqdweb?did=1436351451&sid=25&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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23

Salamat, Julia. "The Role of CYP2A5 in Cadmium-Induced Liver Injury." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3498.

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Cadmium is present in food and groundwater. Tobacco smoking and occupational exposure are also major sources for cadmium. Cadmium is primarily accumulated in liver, a major organ metabolizing exogenous chemicals. Chemical metabolism may cause detoxification, but it can also cause bio-activation resulting in liver damage. Cytochrome P450s (CYP) are major liver metabolism enzymes, and cadmium chloride (CdCl2) can induce CYP2A5 in mice. We examined the effect of CYP2A5 on CdCl2-induced liver injury using CYP2A5-knockout (cyp2a5-/-) mice. The cyp2a5-/- mice and their control WT mice were injected

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24

Uwimana, Eric. "Probing the PCB metabolome: metabolism of chiral and non-chiral polychlorinated biphenyls to chiral hydroxylated metabolites in humans and rats." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6657.

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Polychlorinated biphenyls (PCBs) continue to pose a health concern because of their predominance in the diet and air as well as in environmental samples and humans. PCB congeners with 3 or 4 chlorine substituents in ortho position have been associated with neurodevelopmental disorders. Hydroxylated metabolites (OH-PCBs) of these PCBs are also potentially toxic to the developing brain. Metabolism studies have mainly focused on animal models. However, preliminary data from this dissertation work have revealed PCB metabolism differences between laboratory animal models and humans in terms of meta

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25

Ferla, Salvatore. "Small molecule inhibitors of CYP24A1 for the treatment of various cancers." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/53626/.

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In the last three decades vitamin D, or calcitriol, has been found to have important anticancer role in different cancer types. Unfortunately, a therapy using calcitriol remains a challenge due to increased drug resistance as a consequence of the up-regulation of CYP24A1, which metabolises and inactivates calcitriol. Moreover, the hypercalcaemia associated with an elevated dose of calcitriol does not allow the use of vitamin D at a high concentration. Analogues of calcitriol have enhanced anti-tumour activity, reducing the calcaemic undesired effect. The use of CYP24A1 selective inhibitors cou

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26

Christian, Kyle. "The role of hnRNP A1 and hnRNP C1/C2 in the regulation of the stress responsive genes Cyp2a5/2A6 and p53." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8722.

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<p>The family of proteins known as heterogeneous nuclear ribonucleoproteins (hnRNPs) is large and diverse. Often, one and the same hnRNP will perform multiple cellular functions, leading to their description as “multifunctional proteins”. The two hnRNPs known as hnRNP A1 and hnRNP C1/C2 are multifunctional proteins found to affect the transcription, splicing, stability, and translation of specific genes’ mRNA. They are implicated in carcinogenesis, apoptosis, and DNA damage response mechanisms.</p><p>The aims of this thesis were to study the hnRNP A1 and hnRNP C1/C2 dependent regulation of two

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27

Husseini, Abdallah. "Bone formation during fracture repair in mice deficient for the cyp24a1 gene." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106532.

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Vitamin D is a key regulator of mineral and bone homeostasis. The enzyme CYP24A1 is responsible for transforming vitamin D into 24,25(OH)2D. The putative biological activity of 24,25(OH)2D remains unclear. Previous studies showed an increase in the circulating levels of this metabolite following a fracture in chicks. Our laboratory has engineered a mouse model deficient for the Cyp24a1 gene for studying the role of 24,25(OH)2D. We set out to study the role of 24,25(OH)2D in endochondral and intramembranous bone formation in mammalian fracture repair in this mouse model. Methods: Wild-type and

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28

Menassa, Rita. "Études fonctionnelles et structurales des mutants du gène CYP21A2 dans l'hyperplasie congénitale des surrénales." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00699819.

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Le déficit en 21-hydroxylase est la cause la plus fréquente des hyperplasies congénitales des surrénales. Un grand nombre de nouvelles mutations a été trouvé dans le laboratoire qui centralise la plus grande cohorte de familles au niveau international et l'évaluation de leur sévérité était primordiale pour optimiser la prise en charge des patients (thérapeutique, conseil génétique). Grâce à l'analyse approfondie du phénotype des patients et au développement d'études fonctionnelles (in vitro, in silico), nous avons pu évaluer le retentissement de la plupart des 85 nouvelles mutations ; nous avo

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29

MEDEIROS, BORBA VIEIRA MARIA ISABEL. "Ontogenese du cyp2e1 hepatique humain : regulation de l'expression du gene cyp2e1 par demethylation des residus cpg." Paris 7, 1997. http://www.theses.fr/1997PA077142.

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Les objectifs de ce travail ont ete l'etude de l'ontogenese du cyp2e1 hepatique humain et la mise en evidence des mecanismes moleculaire impliques dans le controle de l'expression du cyp2e1 au cours du developpement. Le cyp2e1 presente une expression uniquement postnatale : la proteine et les activites enzymatiques correspondantes apparaissent au cours des heures qui suivent la naissance, et augmentent graduellement jusqu'a l'age adulte. Le taux d'arnm cyp2e1 reste faible au cours de la periode perinatale, bien que la concentration de la proteine cyp2e1 augmente immediatement apres la naissanc

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30

Truong, Nhu Traï. "Etude de la régulation post-transcriptionnelle du CYP2B1 et 2E1 par l'insuline : mise en évidence et localisation d'une interaction ARN-protéines." Paris 5, 2005. http://www.theses.fr/2005PA05S036.

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Il a été montré que le diabète augmentait l'expression des CYP 2E1 et 2B1 de rat au niveau ARN et protéines. Cette élévation a été attribuée à une stabilisation des ARNm et peut être inversé par un traitement quotidien à l'insuline. En utilisant une lignée d'hépatome de rat, il a été précédemment montré au laboratoire que cette hormone agissait par un mécanisme post-transcriptionnel en diminuant la durée de vie des messagers des CYP2E1 et 2B1 de rat. Nous avons entrepris d'identifier les mécanismes moléculaires mis en jeu dans cette régulation. En utilisant des protéines cytoplasmiques provena

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31

Gullstén, H. (Harriet). "Significance of polymorphisms in CYP2A6 gene." Doctoral thesis, Oulun yliopisto, 2000. http://urn.fi/urn:isbn:9514258576.

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Abstract Cytochrome P450 2A6 (CYP2A6) is involved in the 7-hydroxylation of coumarin, C-oxidation of nicotine, and the metabolism of tobacco specific nitrosamines. Initially in 1995 Fernandez-Salguero et al. reported a genotyping method for three alleles: CYP2A6*1 (wild-type), CYP2A6*2 (variant 1), and CYP2A6*3 (variant 2). Later studies presented in this thesis indicated that the original genotyping method produces erroneous results for the CYP2A6*3 allele due to unspecific PCR conditions and previously unknown CYP2A6*1B allele. Furthermore, the CYP2A6*2 allele genotyping caused erroneous gen

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32

Dranse, Helen. "Molecular and cellular characterization of the CYP26b1-null limb phenotype." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29719.

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Cyp26b1, a retinoic acid (RA)-metabolizing enzyme, is expressed in the developing limb bud and Cyp26b1-/- mice present with severe early limb defects characterized by truncated skeletal elements and oligodactyly. These malformations have previously been attributed to a patterning defect; however, recent reports suggest that RA is dispensable for limb patterning. In this study, we examined the role of endogenous retinoid signalling in skeletogenesis using Cyp26b1-/- mice and transgenic mice in which Cyp26b1 is conditionally deleted under control of the Prrx1 promoter beginning at ~E9.5 (Prrx1

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33

Kien, Thi Sothy. "High calcium diet increases 25-hydroxyvitamin D 1 (Sa (B-hydroxylase (CYP27B1) mRNA levels in bone /." Title page and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09SBT/09sbtk473.pdf.

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34

Hamade, Bachar. "Fracture repair in Cyp24a1 deficient mice: biomechanical properties of repaired bones and contribution to mechanisms involved." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119501.

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Vitamin D is a key modulator and regulator of mineral and bone homeostasis. The main active form of vitamin D in the body is the 1,25-(OH)2D metabolite that is formed in the kidney from 25-(OH)D by the enzyme CYP27B1. The enzyme CYP24A1 initiates the C24-oxidation pathway that leads to degradation of the hormonal form of vitamin D, but is also responsible for the synthesis of 24,25-(OH)2D. The putative biological activity of 24,25-(OH)2D remains unclear, but it has been found that following tibial fractures in chicks, the levels of CYP24A1 activity and serum 24,25-(OH)2D are both elevated. Our

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35

Lindgren, Kristjon, and Dana Seng. "The Effects of Cyp2e1 on Hepatic Gene Expression in 129/Sv-Cyp2e1^tm1Gonz/J and 129S1/SvImJ Mice Exposed to Hydrazine." The University of Arizona, 2007. http://hdl.handle.net/10150/624424.

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Class of 2007 Abstract<br>Objectives: To characterize the difference in hepatic gene expression between Cyp2e1 +/+ and Cyp2e1 -/- mice after exposure to hydrazine in order to elucidate the functional pathway(s) for hydrazine-induced steatosis. Methods: The project was designed by Dr. Charlene McQueen and consisted of the following aims: (1) to characterize the hepatic pathology induced by hydrazine in CYP2E1 +/+ and -/- mice, (2) to evaluate hepatic gene expression profiles following exposure to hydrazine, and (3) to determine the expression of CYP2E1 and CYP4A14. The animal exposure and data

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36

Ulusoy, Gulen. "Genetic Polymorphisms Of Alcohol Inducible Cyp2e1 In Turkish Population." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12604747/index.pdf.

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Cytochrome P4502E1 (CYP2E1), the ethanol-inducible isoform of cytochrome P450 superfamily, catalyzes many low molecular weight endogenous and exogenous compounds, including ethanol, acetone, drugs like acetaminophen and chlorzoxazone, and industrial solvents like benzene and styrene, most of which are carcinogenic. Besides, it has a high capacity to produce reactive oxygen species. CYP2E1 is induced by ethanol and isoniazid, as well by some pathophysiological conditions like diabetes and starvation. CYP2E1 gene shows genetic polymorphisms which are thought to play a major role in interindividu

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Weltman, Martin D. (Martin David). "Pathogenesis of nonalcoholic steatohohepatitis [sic] : the role of CYP2E1." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27739.

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The relevant literature concerning nonalcoholic steatohepatitis (NASH), the morphologically similar condition of alcoholic liver disease (ALD), and the hepatic cytochromes P450 (P450 or CYP) was reviewed with particular emphasis on CYP2E1. CYP2E1 is induced in ALD. It plays an important role in the pathogenesis of this condition by generating reactive oxygen species (ROS). In turn, ROS produce lipid peroxidation, which contributes to the cellular injury in ALD. CYP2E1 is constitutively expressed in acinar zone 3. The early lesions observed in both ALD and NASH are most pronounced in the

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Lindner, Juliane. "Immunmodulation der IgE-Produktion durch autokrine Calcitriol-Synthese." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2017. http://dx.doi.org/10.18452/17768.

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Aktuelle Studien legen nahe, dass ein niedriger Vitamin D-Status assoziiert mit steigenden Breitengraden, mit dem Auftreten von Autoantikörpern und damit einhergehenden Autoimmunerkrankungen positiv korreliert. Trifft UV-B-Strahlung auf die Haut, entsteht aus 7-Dehydrocholesterol nach enzymatischen Prozessen in Leber und Niere, die bioaktive Form von Vitamin D, 1α,25-Dihydroxyvitamin D3 (Calcitriol). Den finalen Stoffwechselschritt katalysiert die 1α-Hydroxylase CYP27B1. Die biologische Wirkung von Calcitriol wird über dessen Bindung an den nukleären Vitamin D-Rezeptor vermittelt, was letztlic

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Bruner, Katherine R. "A transgenic mouse model to study the effects of conditional overexpression of the retinoic acid-metabolizing enzyme, CYP26A1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63275.pdf.

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Beildeck, Marcy Ellen. "The role of vitamin D and the vitamin D receptor in TCF-4 regulation and silencing of CYP24A1." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/454140383/viewonline.

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Huang, Alice. "Calcium-sensing Receptor Mediated Control of CYP27B1 Promoter-dependent Gene & Protein Expression: Complex Extracellular Ca2+ Concentration Dependence." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20127.

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Changes in extracellular Ca2+ (Ca2+o) differentially modulate 25-hydroxyvitamin D3 1α-hydroxylase (1αOHase; encoded by CYP27B1) mRNA and protein levels in cell types including the renal proximal tubule (inhibitory), parathyroid, and skeletal osteoblasts (stimulatory) to control 1,25-dihydroxyvitamin D3 synthesis. We hypothesised that the calcium-sensing receptor (CaSR) mediated Ca2+o concentration-dependent control of 1αOHase, either directly through Ca2+o, or through the local production of parathyroid hormone related peptide (PTHrP). To investigate promoter activity, I transfected a firefly

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Ducassou, Lionel. "Etude biochimique d’un cytochrome P450 de cerveau humain : le CYP2U1." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P642/document.

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Parmi les 57 cytochromes P450 identifiés lors du séquençage complet du génome humain, on en dénombre environ 15 dont on ne connaît pratiquement rien de leurs rôles physiologiques, de leurs substrats, et de leurs structures, d’où le nom de «P450 orphelins». Le CYP2U1 est l’un des cytochromes P450 les plus fortement exprimé au niveau du cerveau et du cervelet mais c’est aussi l’un des plus conservé parmi les différentes espèces du règne animal. Ce travail de thèse a tout d’abord consisté à optimiser les conditions d’expression du CYP2U1 sous une forme active. Un premier système d’expression dans

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Ducassou, Lionel. "Etude biochimique d'un cytochrome P450 de cerveau humain : le CYP2U1." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00799083.

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Parmi les 57 cytochromes P450 identifiés lors du séquençage complet du génome humain, on en dénombre environ 15 dont on ne connaît pratiquement rien de leurs rôles physiologiques, de leurs substrats, et de leurs structures, d'où le nom de "P450 orphelins". Le CYP2U1 est l'un des cytochromes P450 les plus fortement exprimé au niveau du cerveau et du cervelet mais c'est aussi l'un des plus conservé parmi les différentes espèces du règne animal. Ce travail de thèse a tout d'abord consisté à optimiser les conditions d'expression du CYP2U1 sous une forme active. Un premier système d'expression dans

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Stedman, Aline. "Etude du rôle des gènes Iroquois au cours de la régionalisation du cerveau chez le poisson-zèbre." Paris 6, 2009. http://www.theses.fr/2009PA066305.

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Au cours de sa formation, le cerveau des vertébrés est progressivement régionalisé selon l’axe antéroposterieur en prosencéphale, mésencéphale et rhombencéphale. Le rhombencéphale est transitoirement subdivisé en 7 rhombomères (r1-r7). Certains facteurs de trancription sont requis pour la formation des différents rhombomères. Krox20 est ainsi nécessaire à la mise en place de r3 et r5. Au cours de ma thèse, je me suis intéressée au rôle de deux gènes de la famille Iroquois, irx7 et irx1b, dans la régionalisation du cerveau chez le poisson-zèbre. J’ai montré qu’ils étaient nécessaires à la forma

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Quesnot, Nicolas. "Évaluation de la génotoxicité des contaminants environnementaux, production de lignées bio-senseurs et mesure de l'activité enzymatique du cytochrome P450 2E1 dans les cellules d'hépatome humain HepaRG." Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1B005/document.

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L'exposition humaine aux contaminants environnementaux est inévitable du fait de leur présence dans l'eau, l'air et l'alimentation. La plupart d'entre eux sont reconnus comme étant mutagènes et/ou carcinogènes chez l'animal mais ils sont souvent seulement suspectés de l'être chez l'Homme. Le manque de connaissance vis-à-vis des substances chimiques a conduit l'UE à lancer le programme REACH avec l'objectif d'évaluer la toxicité d'environ 30 000 molécules. Cette évaluation nécessiterait l'utilisation de plus de 4 millions d'animaux et la pertinence controversée de ces modèles pourrait aboutir à

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Ramos, Jheneffer Sonara Aguiar. "ANALISE DE POLIMORFISMOS NA REGIÃO PROMOTORA DO GENE CITOCROMO P4502E1 (CYP2E1) EM INDIVÍDUOS ALCOOLISTAS DO MUNICÍPIO DE GOIÂNIA-GO." Pontifícia Universidade Católica de Goiás, 2016. http://localhost:8080/tede/handle/tede/2404.

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Made available in DSpace on 2016-08-10T10:39:12Z (GMT). No. of bitstreams: 1 JHENEFFER SONARA AGUIAR RAMOS.pdf: 3001795 bytes, checksum: 76b7e24451f0b40a66c4247eec7df460 (MD5) Previous issue date: 2016-03-14<br>The Cytochrome P4502E1 (CYP2E1) gene encodes an enzyme which is the main constituent of microsomal ethanol oxidizing system. Genetic variation present in the CYP2E1 gene result in significant differences in enzyme activity, however the functional significance of these variations in the metabolism of ethanol remains controversial, since there is not yet a clear correlation with differe

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Soardi, Fernanda Caroline. "Mutações novas dos genes CYP21A2 e CYP11B1 e suas alferações na atividade enzimatica." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317135.

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Orientadores: Maricilda Palandi de Mello, Anna Wedell<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T13:24:54Z (GMT). No. of bitstreams: 1 Soardi_FernandaCaroline_D.pdf: 4267789 bytes, checksum: 80c77e1664dcc041014d42a92bdd435e (MD5) Previous issue date: 2008<br>Resumo: A causa mais freqüente de hiperplasia congênita da adrenal (HCA) é a deficiência da enzima CYP21A2 responsável por cerca de 90% dos casos, seguida da deficiência de CYP11B1, a qual é responsável por 5-8%. A deficiência de CYP21A2 apresenta difer

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Zeman, Marilyn Vera. "evaluation of coumarin as an in vivo measure of CYP2A6 activity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0026/MQ40853.pdf.

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Karlgren, Maria. "Novel extrahepatic P450 enzymes with emphasis on the tumor specific CYP2W1 /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-139-5/.

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Muangmoonchai, Roongsiri. "Regulation of rat CYP2B1 gene expression : the role of nuclear receptors." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392665.

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