Relevant bibliographies by topics / CYP2C8*5

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'CYP2C8*5'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "CYP2C8*5"

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Niwa, Toshiro, and Yurie Imagawa. "Substrate Specificity of Human Cytochrome P450 (CYP) 2C Subfamily and Effect of Azole Antifungal Agents on CYP2C8." Journal of Pharmacy & Pharmaceutical Sciences 19, no. 4 (2016): 423. http://dx.doi.org/10.18433/j31s53.

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PURPOSE: The metabolic activities of aminopyrine N-demethylation and tolbutamide methylhydroxylation by the human hepatic cytochrome P450 (P450 or CYP) 2C subfamily were compared and the effects of azole antifungal agent on the drug-metabolizing activity of CYP2C8 were investigated. METHODS: Aminopyrine N-demethylation and tolbutamide methylhydroxylation by CYP2C8, CYP2C9, and CYP2C19 were determined by the previous reported methods. The effects of five azole antifungal agents, fluconazole, itraconazole, ketoconazole, miconazole, and voriconazole, on the aminopyrine N-demethylation activity by
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Chamboko, Chiratidzo R., Wayde Veldman, Rolland Bantar Tata, Birgit Schoeberl, and Özlem Tastan Bishop. "Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles." International Journal of Molecular Sciences 24, no. 4 (2023): 3383. http://dx.doi.org/10.3390/ijms24043383.

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Precision medicine gives individuals tailored medical treatment, with the genotype determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or toxicity. Cytochrome P450 (CYP) enzyme families 1, 2, and 3 play a pivotal role in eliminating most drugs. Factors that affect CYP function and expression have a major impact on treatment outcomes. Therefore, polymorphisms of these enzymes result in alleles with diverse enzymatic activity and drug metabolism phenotypes. Africa has the highest CYP genetic diversity and also the highest burden of malaria and tuberculosis
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Zobdeh, Farzin, Ivan I. Eremenko, Mikail A. Akan, et al. "Pharmacogenetics and Pain Treatment with a Focus on Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Antidepressants: A Systematic Review." Pharmaceutics 14, no. 6 (2022): 1190. http://dx.doi.org/10.3390/pharmaceutics14061190.

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Background: This systematic review summarizes the impact of pharmacogenetics on the effect and safety of non-steroidal anti-inflammatory drugs (NSAIDs) and antidepressants when used for pain treatment. Methods: A systematic literature search was performed according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines regarding the human in vivo efficacy and safety of NSAIDs and antidepressants in pain treatment that take pharmacogenetic parameters into consideration. Studies were collected from PubMed, Scopus, and Web of Science up to the cutoff date 18
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Seo, Hyung-Ju, Seung-Bae Ji, Sin-Eun Kim, et al. "Inhibitory Effects of Schisandra Lignans on Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyl Transferases in Human Liver Microsomes." Pharmaceutics 13, no. 3 (2021): 371. http://dx.doi.org/10.3390/pharmaceutics13030371.

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Schisandra chinensis has been widely used as a traditional herbal medicine to treat chronic coughs, fatigue, night sweats, and insomnia. Numerous bioactive components including lignans have been identified in this plant. Lignans with a dibenzocyclooctadiene moiety have been known to possess anti-cancer, anti-inflammatory, and hepatoprotective activity. Fragmentary studies have reported the ability of some lignans to modulate some cytochrome P450 (P450) enzymes. Herein, we investigated the drug interaction potential of six dibenzocyclooctadiene lignans (schisandrin, gomisin A, B, C, and N, and
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Charles, Brown, Larbie Christopher, and Selorm Yao Amuzu Dominic. "Prevalence of the Genetic Mutation CYP2C8*5 in Selected Ethnic Groups in Southern Ghana." International Journal of Biochemistry Research & Review 12, no. 3 (2016): 1–9. https://doi.org/10.9734/IJBCRR/2016/25680.

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Aim: The study determined prevalence of clinically relevant CYP2C8*5 polymorphism in 80 unrelated individuals, from selected ethnic groups in Southern Ghana. Medical history on adverse drug reactions of the subjects and level of dependencyon drugs metabolized by CYP2C8 enzyme was obtained by questionnaire. Allele Specific-PCR analyses were used to genotype CYP2C8*5 alleles in the study subjects. Results: Allelic frequency for CYP2C8*5was 83.75% which was statistically significant (p<0.05). There was no significant difference (p> 0.05) in the prevalence of CYP2C8*5allele within the ethnic
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Park, So-Young, Phi-Hung Nguyen, Gahyun Kim, et al. "Strong and Selective Inhibitory Effects of the Biflavonoid Selamariscina A against CYP2C8 and CYP2C9 Enzyme Activities in Human Liver Microsomes." Pharmaceutics 12, no. 4 (2020): 343. http://dx.doi.org/10.3390/pharmaceutics12040343.

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Like flavonoids, biflavonoids, dimeric flavonoids, and polyphenolic plant secondary metabolites have antioxidant, antibacterial, antiviral, anti-inflammatory, and anti-cancer properties. However, there is limited data on their effects on cytochrome P450 (P450) and uridine 5′-diphosphoglucuronosyl transferase (UGT) enzyme activities. In this study we evaluate the inhibitory potential of five biflavonoids against nine P450 activities (P450s1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A) in human liver microsomes (HLMs) using cocktail incubation and liquid chromatography-tandem mass spectrometry
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Park, Eun Jeong, Ria Park, Ji-Hyeon Jeon, et al. "Inhibitory Effect of AB-PINACA, Indazole Carboxamide Synthetic Cannabinoid, on Human Major Drug-Metabolizing Enzymes and Transporters." Pharmaceutics 12, no. 11 (2020): 1036. http://dx.doi.org/10.3390/pharmaceutics12111036.

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Indazole carboxamide synthetic cannabinoid, AB-PINACA, has been placed into Schedule I of the Controlled Substances Act by the US Drug Enforcement Administration since 2015. Despite the possibility of AB-PINACA exposure in drug abusers, the interactions between AB-PINACA and drug-metabolizing enzymes and transporters that play crucial roles in the pharmacokinetics and efficacy of various substrate drugs have not been investigated. This study was performed to investigate the inhibitory effects of AB-PINACA on eight clinically important human major cytochrome P450s (CYPs) and six uridine 5′-diph
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Denisenko, N. P., Sh P. Abdullaev, K. A. Akmalova, et al. "Structure of the distribution of genetic determinants of the efficacy and safety of non-steroidal anti-inflammatory drugs in the Russian population: focus on CYP2C8, PTGS1 and PTGS2." Modern Rheumatology Journal 16, no. 1 (2022): 60–67. http://dx.doi.org/10.14412/1996-7012-2022-1-60-67.

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The efficacy and safety of non-steroidal anti-inflammatory drugs (NSAIDs) may be determined by the polymorphic nature of the CYP2C8, PTGS1 and PTGS2 genes.Objective: to analyze the nature of the distribution of CYP2C8*3 (rs10509681), CYP2C8*3 (rs11572080), PTGS1 (rs10306135), PTGS1 (rs12353214) and PTGS2 (rs20417) among residents of the North Caucasus.Patients and methods. The study involved 676 volunteers from Russian, Balkar, Kabardian and Ossetian ethnic groups. Carriage of polymorphic markers CYP2C8, PTGS1 and PTGS2 was determined using real-time polymerase chain reaction.Results and discu
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Crosby, Samantha V., Izzeldin Y. Ahmed, Laura R. Osborn, et al. "Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes." Metabolites 12, no. 8 (2022): 773. http://dx.doi.org/10.3390/metabo12080773.

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In 2019, synthetic cannabinoids accounted for more than one-third of new drugs of abuse worldwide; however, assessment of associated health risks is not ethical for controlled and often illegal substances, making CD-1 mouse exposure studies the gold standard. Interpretation of those findings then depends on the similarity of mouse and human metabolic pathways. Herein, we report the first comparative analysis of steady-state metabolism of N-(1-adamantyl)-1-(5-pentyl)-1H-indazole-3-carboxamide (5F-APINACA/5F-AKB48) in CD-1 mice and humans using hepatic microsomes. Regardless of species, 5F-APINA
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Ximenes, Rosana Christine Cavalcanti, Bashir Ahmed, Vahid Nikoui, Khuseyn Egamnazarov, and Muhammad Imran Khan. "Polymorphisms in CYP2C8 gene in Pakistani population and their frequencies in various ethnic groups." Molecular Medicine Communications 1, no. 1 (2021): 03–16. http://dx.doi.org/10.55627/mmc.001.01.0016.

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Cytochrome P4502C8 represents 7% of the hepatic cytochrome system and metabolizes around 5% of drugs in phase I processes. It also plays a significant role in the metabolism of endogenous compounds. More than 20 single nucleotide polymorphisms (SNPs) have been reported, mainly in exon 3, 5, and 8. Some of the SNP’s lead to decreased enzyme activity and may have impact on drug metabolism. This research study aims to determine the frequencies of the most common SNPs of the CYP2C8 gene (CYP2C8*2, *3, *4) in the Pakistani population. A cross-sectional study consisting of 391 healthy humans was con
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Dissertations / Theses on the topic "CYP2C8*5"

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Drogemoller, Britt I. "Detection of sequence diversity in the CYP2C19 gene of Xhosa South African individuals : an analytical and comparative study including in silico and functional analysis of the 5’ flanking region." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/4829.

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Thesis (MSc (Genetics))--University of Stellenbosch, 2010.<br>Thesis presented in partial fulfilment of the requirements for the degree of Master of Science (MSc) in Genetics at Stellenbosch University.<br>ENGLISH ABSTRACT: The prevalence of adverse drug reactions (ADR) and treatment failure in South Africa requires urgent addressing and it is the aim of pharmacogenetics to aid in the alleviation of these ADRs and treatment failures. However, considering the high level of genetic diversity present in African populations, preliminary analysis of the genetic profiles of South African populat
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Book chapters on the topic "CYP2C8*5"

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Korzekwa, Ken. "Case Study 5: Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1554-6_24.

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Lima, Victória Gomes de França, and Lucas Felipe de Melo Alcântara. "A Farmacogenética como ferramenta para aperfeiçoar e reduzir efeitos adversos do tratamento para depressão." In Avanços em Genética Humana um panorama do 1° simpósio da LAGH. Instituto Internacional Despertando Vocações, 2024. http://dx.doi.org/10.31692/978-65-88970-44-7.41-43.

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A farmacoterapia para distúrbios neuropsiquiátricos, como a depressão, tem sido caracterizada por vários estudos como uma variabilidade interindividual bastante significativa na resposta aos medicamentos antidepressivos e pelo desenvolvimento de efeitos adversos. Além disso, a resistência aos antidepressivos é um fenômeno que pode ocorrer por uma prescrição realizada sem o conhecimento do tipo de metabolizador e culmina numa ineficácia terapêutica. O metabolismo desses medicamentos antidepressivos ocorre principalmente através das isoenzimas CYP2D6, CYP2C9, CYP2C19, CYP3A4 e CYP1A21 e os statu
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Silva, Gabriel Ferreira da, Danyele Karla de Souza Silva, Júlia Roberta da Silva Ferreira, and Juliana Renata da Silva Ferreira. "Impacto de polimorfismos genéticos no citocromo P450 na resposta ao tratamento do Transtorno Depressivo Maior (TDM)." In Avanços em Genética Humana um panorama do 1° simpósio da LAGH. Instituto Internacional Despertando Vocações, 2024. http://dx.doi.org/10.31692/978-65-88970-44-7.54-55.

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O transtorno depressivo maior (TDM), conhecido como depressão unipolar, é uma doença crônica multifatorial envolvendo susceptibilidade genética, fatores ambientais, estresse e processos inflamatórios1 . Segundo a Organização Mundial de Saúde (OMS), a depressão é uma das principais causas de incapacidade física e mental no mundo. Estima-se que 280 milhões de pessoas no mundo sofrem de depressão, correspondendo a 3,8% da população, incluindo 5% dos adultos, além disso, cerca de 700 mil pessoas morrem por suicídio anualmente. O tratamento da depressão maior abrange o uso de antidepressivos que au
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Conference papers on the topic "CYP2C8*5"

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Costa, José Cássio Figueira. "PREDIÇÃO DAS PROPRIEDADES FÍSICO-QUÍMICAS E FARMACOCINÉTICAS DO 7-HIDROXI-5-ACETOXIBISABOLENO: NOVA MOLÉCULA CONGÊNERE DO ALFA-BISABOLOL IDENTIFICADO EM LYCHNOPHORA ERICOIDES MART." In II Congresso Brasileiro de Biotecnologia On-line. Revista Multidisciplinar de Educação e Meio Ambiente, 2022. http://dx.doi.org/10.51189/conbiotec/49.

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Introdução: O metabolismo secundário vegetal é uma das principais responsáveis pela produção de uma grande diversidade de moléculas com potencial bioativo. A elucidação e caracterização molecular de novos compostos bioativos geram bases para estudos químicos e biológicos visando à produção e desenvolvimento de novos fármacos. A quimioinformática torna viável, a partir de algoritmos, a caracterização molecular de substâncias com estruturas elucidadas. O 7-hidroxi-5-acetoxibisaboleno (BoAcet) é um análogo terpenoídico do alfa-bisabolol, possui um agrupamento acetóxi ligado a um carbono secundári
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Wang, Xiaodong, Zhi-Yi Zhang, Jing Wang, et al. "Abstract C62: Effects of rolapitant on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP2C8) in healthy subjects." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-c62.

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Costa, José Cássio Figueira, and Elaine Cristinha Pacheco De Oliveira. "FARMACOCINÉTICA E TOXICIDADE IN SILICO DE HIDROCARBONETOS SESQUITERPÊNICOS DO ÓLEO ESSENCIAL DE CROTON CAJUÇARA BENTH (EUPHORBIACEAEA)." In II Congresso Brasileiro de Biotecnologia On-line. Revista Multidisciplinar de Educação e Meio Ambiente, 2022. http://dx.doi.org/10.51189/conbiotec/48.

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Introdução: Croton cajuçara, conhecida popularmente como Sacaca, é uma planta nativa da região Amazônica, comumente utilizada na forma de extratos etanólicos e hidroalcoólicos por populações tradicionais no tratamento de distúrbios no trato digestivo, diabetes, inflamações no fígado, além de auxiliar no tratamento de malária. Entretanto, as propriedades farmacocinéticas (ADME - Absorção, distribuição, metabolismo e excreção) e toxicidade ainda são pouco elucidadas. Diversas ferramentas in sílico são utilizadas para predizer mecanismos de distribuição, interação e toxicidade de compostos bioati
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