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Journal articles on the topic 'CYP2C8*5 Polymorphism in Ghana'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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1

Charles, Brown, Larbie Christopher, and Selorm Yao Amuzu Dominic. "Prevalence of the Genetic Mutation CYP2C8*5 in Selected Ethnic Groups in Southern Ghana." International Journal of Biochemistry Research & Review 12, no. 3 (2016): 1–9. https://doi.org/10.9734/IJBCRR/2016/25680.

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Aim: The study determined prevalence of clinically relevant CYP2C8*5 polymorphism in 80 unrelated individuals, from selected ethnic groups in Southern Ghana. Medical history on adverse drug reactions of the subjects and level of dependencyon drugs metabolized by CYP2C8 enzyme was obtained by questionnaire. Allele Specific-PCR analyses were used to genotype CYP2C8*5 alleles in the study subjects. Results: Allelic frequency for CYP2C8*5was 83.75% which was statistically significant (p<0.05). There was no significant difference (p> 0.05) in the prevalence of CYP2C8*5allele within the ethnic
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2

Milovanovic, DD, JR Milovanovic, M. Radovanovic, et al. "The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients." Balkan Journal of Medical Genetics 19, no. 1 (2016): 21–28. http://dx.doi.org/10.1515/bjmg-2016-0003.

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AbstractThe aim of the present study was to investigate the distribution of CYP2C8 variants *3 and *5, as well as their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients on carbamazepine treatment. Genotyping was conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and allele-specific (AS)-PCR methods, and steady-state carbamazepine plasma concentrations were determined by high performance liquid chromatography (HPLC). The CYP2C8 *3 and *5 polymorphisms were found at frequencies of 17.5 and 0.0%, respectively. After
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3

Ximenes, Rosana Christine Cavalcanti, Bashir Ahmed, Vahid Nikoui, Khuseyn Egamnazarov, and Muhammad Imran Khan. "Polymorphisms in CYP2C8 gene in Pakistani population and their frequencies in various ethnic groups." Molecular Medicine Communications 1, no. 1 (2021): 03–16. http://dx.doi.org/10.55627/mmc.001.01.0016.

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Cytochrome P4502C8 represents 7% of the hepatic cytochrome system and metabolizes around 5% of drugs in phase I processes. It also plays a significant role in the metabolism of endogenous compounds. More than 20 single nucleotide polymorphisms (SNPs) have been reported, mainly in exon 3, 5, and 8. Some of the SNP’s lead to decreased enzyme activity and may have impact on drug metabolism. This research study aims to determine the frequencies of the most common SNPs of the CYP2C8 gene (CYP2C8*2, *3, *4) in the Pakistani population. A cross-sectional study consisting of 391 healthy humans was con
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4

Denisenko, N. P., Sh P. Abdullaev, K. A. Akmalova, et al. "Structure of the distribution of genetic determinants of the efficacy and safety of non-steroidal anti-inflammatory drugs in the Russian population: focus on CYP2C8, PTGS1 and PTGS2." Modern Rheumatology Journal 16, no. 1 (2022): 60–67. http://dx.doi.org/10.14412/1996-7012-2022-1-60-67.

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The efficacy and safety of non-steroidal anti-inflammatory drugs (NSAIDs) may be determined by the polymorphic nature of the CYP2C8, PTGS1 and PTGS2 genes.Objective: to analyze the nature of the distribution of CYP2C8*3 (rs10509681), CYP2C8*3 (rs11572080), PTGS1 (rs10306135), PTGS1 (rs12353214) and PTGS2 (rs20417) among residents of the North Caucasus.Patients and methods. The study involved 676 volunteers from Russian, Balkar, Kabardian and Ossetian ethnic groups. Carriage of polymorphic markers CYP2C8, PTGS1 and PTGS2 was determined using real-time polymerase chain reaction.Results and discu
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5

Niemi, M. "Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide." Clinical Pharmacology & Therapeutics 74, no. 4 (2003): 380–87. http://dx.doi.org/10.1016/s0009-9236(03)00228-5.

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6

Brown, Charles, Christopher Larbie, and Dominic Amuzu. "Prevalence of the Genetic Mutation CYP2C8*5 in Selected Ethnic Groups in Southern Ghana." International Journal of Biochemistry Research & Review 12, no. 3 (2016): 1–9. http://dx.doi.org/10.9734/ijbcrr/2016/25680.

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7

Pereira de Sena, Luann Wendel, Hellen Thais Fuzii, Fabiola Elizabeth Villanova, et al. "Influence of CYP2C8 Polymorphism on the Exposure to Chloroquine in Patients with Malaria by Plasmodium vivax—A Preliminary Study." International Journal of Environmental Research and Public Health 22, no. 3 (2025): 336. https://doi.org/10.3390/ijerph22030336.

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Aim: To assess the impact of the CYP2C82 polymorphism on chloroquine and desethylchloroquine concentrations in patients with malaria caused by P. vivax. Methods: A prospective study was conducted on patients with malaria in an endemic area of the Amazon basin. Liquid chromatography was employed to measure the levels of chloroquine and desethylchloroquine, while molecular methods estimated the frequency of the CYP2C82 variant. Results: This study revealed that plasma levels of chloroquine were higher in patients with the CYP2C82 polymorphism compared to those without this variant. The differenc
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8

Patil, Madhavi N., Kailas D. Datkhile, Anand K. Gudur, Rashmi A. Gudur, and Satish R. Patil. "Single-nucleotide polymorphism in CYP1A1, CYP1B1, CYP2B6, CYP2C8, and CYP2C9 genes and their association with gastrointestinal cancer: A hospital-based case-control study." Journal of Cancer Research and Therapeutics 20, no. 1 (2023): 216–23. http://dx.doi.org/10.4103/jcrt.jcrt_294_22.

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Background: Cytochrome P450 (CYP) comprises a group of phase-I metabolizing enzymes that are important in xenobiotics metabolism. Genetic polymorphism of CYPs has been comprehensively studied for their association with a range of diseases. In this study, we assessed single-nucleotide polymorphism (SNP) of CYP1A, CYP1B, CYP2B, and CYP2C and their role in gastrointestinal (GI) cancer susceptibility in the rural population of Maharashtra. Materials and Methods: In this hospital-based case-control study, the association of polymorphism of CYP genes was studied by the polymerase chain reaction-rest
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9

Lundtoft, Christian, Anthony Afum-Adjei Awuah, Alptekin Güler та ін. "An IL7RA exon 5 polymorphism is associated with impaired IL-7Rα splicing and protection against tuberculosis in Ghana". Genes & Immunity 20, № 6 (2018): 514–19. http://dx.doi.org/10.1038/s41435-018-0049-5.

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10

Zhiryakova, A. S., N. P. Denisenko, S. N. Tuchkova, et al. "Pharmacogenetic aspects of the efficacy of nonsteroidal anti-inflammatory drugs and opioid analgesics for postoperative pain relief after total joint arthroplasty." Modern Rheumatology Journal 19, no. 3 (2025): 40–47. https://doi.org/10.14412/1996-7012-2025-3-40-47.

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Objective: to investigate possible associations between genetic, clinical, laboratory, and demographic parameters and the level of pain in the early postoperative (p/o) period, the need for opioid analgesics, and gastrointestinal symptoms in patients who underwent primary total knee (TKR) or hip replacement (THR).Material and methods. Sixty-one patients hospitalized for THR or TKR were included in the study. P/o pain relief was achieved using nonsteroidal anti-inflammatory drugs (NSAIDs) – ketoprofen or ketorolac – with tramadol prescribed "on demand." Pain was assessed in all patients using t
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11

Quan, Hong, Peng Yu, Kokouvi Kassegne, Hai-Mo Shen, Shen-Bo Chen, and Jun-Hu Chen. "Polymorphism of Drug Resistance Genes dhfr and dhps in Plasmodium falciparum Isolates among Chinese Migrant Workers Who Returned from Ghana in 2013." Tropical Medicine and Infectious Disease 8, no. 11 (2023): 504. http://dx.doi.org/10.3390/tropicalmed8110504.

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In 2013, an epidemic of falciparum malaria involving over 820 persons unexpectedly broke out in Shanglin County, Guangxi Zhuang Autonomous Region, China, after a large number of migrant workers returned from Ghana, where they worked as gold miners. Herein, we selected 146 isolates randomly collected from these patients to investigate the resistance characteristics of the parasite to sulfadoxine–pyrimethamine (SP) by screening mutations in the dhfr and dhps genes. All 146 isolates were successfully genotyped for dhps, and only 137 samples were successfully genotyped for dhfr. In the dhfr gene,
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12

PADI, F. K., A. OFORI, and A. ARTHUR. "Genetic variation and combining abilities for vigour and yield in a recurrent selection programme for cacao." Journal of Agricultural Science 155, no. 3 (2016): 444–64. http://dx.doi.org/10.1017/s0021859616000459.

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SUMMARYThe low genetic diversity of cacao germplasm collections in West Africa is often cited as a limitation to further yield improvement of the crop in its major production countries. Twelve clones obtained from first cycle selection for yield and clones available in international genebanks were tested for their combining ability for key agronomic traits by using these as males in crosses with five female clones available in the Seed Gardens in Ghana. Progenies obtained from a North Carolina II (NC II) mating design and standard varieties were planted at two sites that contrast in terms of s
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13

Demorais, S. M. F., H. Schweikl, J. Blaisdell, and J. A. Goldstein. "Gene Structure and Upstream Regulatory Regions of Human CYP2C9 and CYP2C18." July 1, 1993. https://doi.org/10.1006/bbrc.1993.1803.

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There is a genetic polymorphism in humans in the metabolism of S-mephenytoin which has been suggested to be mediated by either CYP2C18 or CYP2C9. We have isolated genomic clones for CYP2C9 and CYP2C18 from the liver of an individual phenotyped in vitro as an extensive metabolizer of S-mephenytoin. Analysis of the genes reveals nine coding exons spanning approximately 55 kb. The intron-exon organization was similar to that of other members of the CYP2C subfamily. Analysis of 2200 bp of 5′ upstream sequence for CYP2C9 and 1300 bp 5′ upstream sequence for CYP2C18 reveals canonical TATA boxes situ
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14

Diaba-Nuhoho, Patrick. "Interleukin-4 and its receptor alpha in paediatric uncomplicated malaria patients from a Ghanaian case-control study." BMC Research Notes 17, no. 1 (2024). http://dx.doi.org/10.1186/s13104-024-06984-5.

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Abstract Objectives This study investigated gene polymorphisms in the interleukin-4 (IL-4) and its receptor alpha (IL-4Rα) gene regions in human hosts with uncomplicated malaria. Data description Blood samples were obtained from a case-control study conducted at the Sogakope district hospital in the Volta region of Ghana. Thick blood films were made and used to detect the presence and levels of parasitaemia in the patient samples. Genotyping of IL-4 (150 C/T) and the IL-4Rα (Pro-478-Ser) polymorphisms in the promoter regions and receptor gene was performed using polymerase chain reaction-restr
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15

Tchum, Samuel Kofi, Fareed Arthur, Samuel Asamoah Sakyi, et al. "Effect of IgG3 Hinge Region Length Polymorphisms on Iron Fortification among Rural Pre-School Ghanaian Children and Its Associated Risk to Malaria and Anaemia." Food Science & Nutrition Research 4, no. 1 (2021). http://dx.doi.org/10.33425/2641-4295.1042.

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Sub-Saharan African pre-school children have an interdependence among immune response, infection resistance and adaptive effect of the dietary intake. However, the long hinge region of immunoglobulin G3 makes binding easy to malaria antigens and receptors, eliciting a more protective response among subclasses of immunoglobulin G. However, it is unknown if iron-containing multimicronutrients are associated with risk of anaemia and malaria in pre-school children with hinge region G3 immunoglobulin polymorphism living in high malaria transmission areas. We aimed to determine the impact of iron fo
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16

Oteng-Frimpong, Richard, Benjamin Karikari, Emmanuel Kofi Sie, et al. "Multi-locus genome-wide association studies reveal genomic regions and putative candidate genes associated with leaf spot diseases in African groundnut (Arachis hypogaea L.) germplasm." Frontiers in Plant Science 13 (January 5, 2023). http://dx.doi.org/10.3389/fpls.2022.1076744.

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Early leaf spot (ELS) and late leaf spot (LLS) diseases are the two most destructive groundnut diseases in Ghana resulting in ≤ 70% yield losses which is controlled largely by chemical method. To develop leaf spot resistant varieties, the present study was undertaken to identify single nucleotide polymorphism (SNP) markers and putative candidate genes underlying both ELS and LLS. In this study, six multi-locus models of genome-wide association study were conducted with the best linear unbiased predictor obtained from 294 African groundnut germplasm screened for ELS and LLS as well as image-bas
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