Relevant bibliographies by topics / CYP450-derived eicosanoids

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  2. Dissertations / Theses

Academic literature on the topic 'CYP450-derived eicosanoids'

Author: Grafiati
Published: 11 March 2023

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Journal articles on the topic "CYP450-derived eicosanoids"

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Milne, Ginger L., Robert A. Vierkant, Amy C. Degnim, et al. "Abstract 6333: Quantification of oxylipins as biomarkers of inflammation and cancer risk in breast tissue." Cancer Research 82, no. 12_Supplement (2022): 6333. http://dx.doi.org/10.1158/1538-7445.am2022-6333.

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Abstract Arachidonic acid (AA) metabolizing enzymes, including cyclooxygenases (COX), lipoxygenases, and cytochrome P450s (CYP450), are expressed in breast cancer (BC). Elevated levels of metabolites of COX-derived, pro-inflammatory prostaglandin (PGs) metabolites in urine have been linked to increased risk of developing breast cancer (BC) in two large prospective cohorts. Further, CYP450-derived EETs in BC tumors are associated with metastasis. We hypothesize that measuring levels of AA-derived oxylipins in breast tissues could enable improved BC risk prediction, provide insights into pro-car
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Hoxha, M., V. Malaj, and B. Zappacosta. "AB0097 EFFECT OF CYTOCHROME P450 METABOLITES OF ARACHIDONIC ACID IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1179.2–1179. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4779.

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BackgroundArachidonic acid (AA) is a polyunsaturated fatty acid, released in inflammatory disease, such as rheumatoid arthritis (RA). Cyclooxygenase (COX) and lypooxygenase (LOX) pathways have received greater attention than cytochrome P450 (CYP) pathway of AA, which also plays a significant role in RA. AA is a substrate of CYP enzymes through two different pathways: the ω-hydroxylase, and epoxygenase pathways, respectively. The epoxygenase gives rise to epoxyeicosatrienoic acids (EETs) (5,6-EET, 8,9-EET, 11,12-EET, 14,15-EET), whereas ω- hydroxylase produces hydroxyeicosatetraenoic acids (HET
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Rodríguez-Carrio, J., R. Coras, M. Alperi-López, et al. "THU0065 OXYLIPIN PROFILING DURING THE VERY EARLY PHASE OF RHEUMATOID ARTHRITIS: ASSOCIATIONS WITH DISEASE STAGE, CLINICAL FEATURES AND TREATMENT RESPONSE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 245.2–245. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3236.

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Background:traditional approaches and lipidomics support the relevance of eicosanoids in rheumatic conditions, such as rheumatoid arthritis (RA). Previous studies from our group and others have revealed altered levels of arachidonic acid in RA, pointing to a possible consumption or enhanced metabolisation. However, the potential alterations of its actual metabolites are difficult to assess with conventional approaches, and new, untargeted, high-throughput technologies are needed. More importantly, whether these alterations are related to the disease course and could be found at the very early
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Oyekan, A. O., and J. C. McGiff. "Cytochrome P-450-derived eicosanoids participate in the renal functional effects of ET-1 in the anesthetized rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 274, no. 1 (1998): R52—R61. http://dx.doi.org/10.1152/ajpregu.1998.274.1.r52.

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We evaluated the contribution of cytochrome P-450 (CYP450)-dependent arachidonic acid (AA) metabolites and prostanoids to the renal hemodynamic and tubular effects of endothelin-1 (ET-1) in anesthetized rats. Either ET-1 (0.3, 1.0, and 3 pmol ⋅ kg−1 ⋅ min−1) or vehicle was infused intravenously during two to three 30-min clearance experimental periods. Only high-dose ET-1 increased mean arterial pressure: control, 75 ± 3 mmHg vs. experimental, 84 ± 4 mmHg. A dose-dependent diuretic-natriuretic response to ET-1 occurred despite progressive declines in glomerular filtration rate (GFR) and renal
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5

Hercule, H. C., and A. O. Oyekan. "Role of NO and cytochrome P-450-derived eicosanoids in ET-1-induced changes in intrarenal hemodynamics in rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 279, no. 6 (2000): R2132—R2141. http://dx.doi.org/10.1152/ajpregu.2000.279.6.r2132.

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Endothelin-1 (ET-1) produces potent renal effects that we have previously shown to be dependent on cytochrome P-450 (CYP450) metabolites of aracidonic acid (24) This study evaluated the role of these metabolites in the effects produced by ET-1 on renal blood flow (RBF), cortical blood flow (CBF), medullary blood flow (MBF), and mean arterial blood pressure (MBP). ET-1 (20–200 pmol/kg) increased MBP, renal vascular resistance (RVR), and MBF but reduced CBF and RBF in a dose-dependent manner. The decreases in CBF and RBF, and increases in MBP and RVR were blunted by BMS-182874, an ET a receptor
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Baragatti, Barbara, Michal Laniado Schwartzman, Debora Angeloni, et al. "EDHF function in the ductus arteriosus: evidence against involvement of epoxyeicosatrienoic acids and 12S-hydroxyeicosatetraenoic acid." American Journal of Physiology-Heart and Circulatory Physiology 297, no. 6 (2009): H2161—H2168. http://dx.doi.org/10.1152/ajpheart.00576.2009.

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We have previously shown (Ref. 2 ) that endothelium-derived hyperpolarizing factor (EDHF) becomes functional in the fetal ductus arteriosus on removal of nitric oxide and carbon monoxide. From this, it was proposed that EDHF originates from a cytochrome P-450 (CYP450)-catalyzed reaction being inhibited by the two agents. Here, we have examined in the mouse ductus whether EDHF can be identified as an arachidonic acid product of a CYP450 epoxygenase and allied pathways. We did not detect transcripts of the mouse CYP2C subfamily in vessel, while CYP2J subfamily transcripts were expressed with CYP
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7

Vaittinen, Maija, Maria A. Lankinen, Pirjo Käkelä, et al. "The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism." European Journal of Nutrition, June 14, 2022. http://dx.doi.org/10.1007/s00394-022-02922-y.

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Abstract Purpose Fatty acid desaturase (FADS) variants associate with fatty acid (FA) and adipose tissue (AT) metabolism and inflammation. Thus, the role of FADS1 variants in the regulation of dietary linoleic acid (LA)-induced effects on AT inflammation was investigated. Methods Subjects homozygotes for the TT and CC genotypes of the FADS1-rs174550 (TT, n = 25 and CC, n = 28) or -rs174547 (TT, n = 42 and CC, n = 28), were either recruited from the METabolic Syndrome In Men cohort to participate in an intervention with LA-enriched diet (FADSDIET) or from the Kuopio Obesity Surgery (KOBS) study
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Dissertations / Theses on the topic "CYP450-derived eicosanoids"

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Sara, Bonafini. "RELATION BETWEEN OBESITY AND BLOOD PRESSURE IN CHILDREN: POSSIBLE ROLE OF POLYUNSATURATED FATTY ACIDS AND THEIR METABOLITES VIA CYTOCHROME P450." Doctoral thesis, 2017. http://hdl.handle.net/11562/970373.

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