Academic literature on the topic 'Cysteine, N-acetyl Cysteine'

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Journal articles on the topic "Cysteine, N-acetyl Cysteine"

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Mikołajczyk, Oskar, Aleksandra Suchołbiak, Aleksander Małachowski, et al. "Expanding Horizons – A Broad-Spectrum Review of Emerging Medical Applications of N-Acetylcysteine." Quality in Sport 43 (July 9, 2025): 62333. https://doi.org/10.12775/qs.2025.43.62333.

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N-acetyl-l-cysteine is a thiol-containing compound widely recognized for its antioxidant, mucolytic, and glutathione-replenishing properties. Historically established for use in acetaminophen toxicity and respiratory diseases, n-acetyl-l-cysteine has garnered growing interest for its broad therapeutic potential across diverse medical domains. This narrative review synthesizes evidence from meta-analyses published from January 2024 onwards, sourced from PubMed, to present emerging clinical applications of n-acetyl-l-cysteine. Findings suggest promising roles for n-acetyl-l-cysteine as an adjunc
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Martínez-Banaclocha, Marcos. "N-acetyl-cysteine in Schizophrenia: Potential Role on the Sensitive Cysteine Proteome." Current Medicinal Chemistry 27, no. 37 (2020): 6424–39. http://dx.doi.org/10.2174/0929867326666191015091346.

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Background: N-acetyl-cysteine (NAC) has shown widespread utility in different psychiatric disorders, including a beneficial role in schizophrenic patients. Although the replenishment of glutathione and the antioxidant activity of NAC have been suggested as the mechanisms that improve such a wide range of disorders, no one seems to be sufficiently specific to explain these intriguing effects. A sensitive cysteine proteome is emerging as a functional and structural network of interconnected sensitive cysteine-containing proteins (SCCPs) that together with reactive species and the cysteine/glutat
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De Vries, Nico, and Silvio De Flora. "N-acetyl-l-cysteine." Journal of Cellular Biochemistry 53, S17F (1993): 270–77. http://dx.doi.org/10.1002/jcb.240531040.

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Park, Taehoon, Ju-Hee Oh, Joo Hyun Lee, Sang Park, Young Jang, and Young-Joo Lee. "Oral Administration of (S)-Allyl-l-Cysteine and Aged Garlic Extract to Rats: Determination of Metabolites and Their Pharmacokinetics." Planta Medica 83, no. 17 (2017): 1351–60. http://dx.doi.org/10.1055/s-0043-111895.

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Abstract(S)-Allyl-l-cysteine is the major bioactive compound in garlic. (S)-Allyl-l-cysteine is metabolized to (S)-allyl-l-cysteine sulfoxide, N-acetyl-(S)-allyl-l-cysteine, and N-acetyl-(S)-allyl-l-cysteine sulfoxide after oral administration. An accurate LC-MS/MS method was developed and validated for the simultaneous quantification of (S)-allyl-l-cysteine and its metabolites in rat plasma, and the feasibility of using it in pharmacokinetic studies was tested. The analytes were quantified by multiple reaction monitoring using an atmospheric pressure ionization mass spectrometer. Because sign
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Hickman, RJS, BJ Christie, RW Guy, and TJ White. "Synthesis of Aromatic S-Sustituted Derivatives of N-Acetyl-L-cysteine." Australian Journal of Chemistry 38, no. 6 (1985): 899. http://dx.doi.org/10.1071/ch9850899.

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A new method for the preparation of aromatic, S-substituted derivatives of N-acetyl-L- cysteine is described. The method involves nucleophilic substitution of aromatic iodides by N-acetyl-L- cysteine in the presence of copper(I) iodide, and provides the first example of nucleophilic substitution of unactivated aromatic halides by N-acetyl-L- cysteine . The method has been used to prepare N-acetyl-S-(2-thienyl)-L- cysteine and N-acetyl-S-(3-thienyl)-L- cysteine from 2-iodothiophen and 3-iodothiophen respectively. In addition, the method has been successfully applied to iodobenzene and 1-iodonap
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Makarov, Sergei V., Elizaveta A. Pokrovskaya, Denis S. Salnikov, and Anastasiya V. Amanova. "INFLUENCE OF L-CYSTEINE AND N-ACETYL-L-CYSTEINE ON REDUCING ACTIVITY OF THIOUREA DIOXIDE IN AQUEOUS SOLUTIONS." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 63, no. 10 (2020): 4–10. http://dx.doi.org/10.6060/ivkkt.20206310.6257.

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The influence of L-cysteine and N-acetyl-L-cysteine on the stability and reducing activity of thiourea dioxide (NH2)2CSO2 (TDO) in the reaction with azo dye Orange II has been studied. The addition of L-cysteine and N-acetyl-L-cysteine leads to the increase in reducing activity of TDO in weakly acidic, neutral and weakly alkaline solutions, but does not influence its reducing activity in strongly alkaline solutions. In alkaline solutions, the rate of reduction of Orange II is increasing, but the influence of additives of thiol acids is decreasing. The activating effect of N-ace-tyl-L-cysteine
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Kandiş, Hayati, Melih Engin Erkan, Ümran Yildirim, et al. "Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication." Human & Experimental Toxicology 30, no. 9 (2010): 1350–58. http://dx.doi.org/10.1177/0960327110391384.

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Aim: The aim of the present study was to investigate the therapeutic and preventive effects of N-acetyl cysteine and erdosteine on renal injury associated with paracetamol (acetaminophen) intoxication. Materials and methods: Female albino Wistar rats were divided into six groups: control; paracetamol (1 g/kg, oral); paracetamol (1 g/kg, oral) + erdosteine (150 mg/kg/day, oral); paracetamol (1 g/kg, oral) + N-acetyl cysteine (140 mg/kg bolus, followed by 70 mg/kg, oral); N-acetyl cysteine control (140 mg/kg bolus, followed by 70 mg/kg, oral); and erdosteine control (150 mg/kg/day, oral). Potent
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Martinez-Banaclocha, Marcos A. "Targeting the Cysteine Redox Proteome in Parkinson’s Disease: The Role of Glutathione Precursors and Beyond." Antioxidants 12, no. 7 (2023): 1373. http://dx.doi.org/10.3390/antiox12071373.

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Encouraging recent data on the molecular pathways underlying aging have identified variants and expansions of genes associated with DNA replication and repair, telomere and stem cell maintenance, regulation of the redox microenvironment, and intercellular communication. In addition, cell rejuvenation requires silencing some transcription factors and the activation of pluripotency, indicating that hidden molecular networks must integrate and synchronize all these cellular mechanisms. Therefore, in addition to gene sequence expansions and variations associated with senescence, the optimization o
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Uttamsingh, Vinita, D. A. Keller, and M. W. Anders. "Acylase I-Catalyzed Deacetylation ofN-Acetyl-l-cysteine andS-Alkyl-N-acetyl-l-cysteines‡." Chemical Research in Toxicology 11, no. 7 (1998): 800–809. http://dx.doi.org/10.1021/tx980018b.

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Rababa’h, Abeer M., Salil V. Deo, Salah E. Altarabsheh, et al. "N-Acetyl Cysteine Therapy Does Not Prevent Renal Failure in High-Risk Patients Undergoing Open-Heart Surgery." Heart Surgery Forum 19, no. 1 (2016): 016. http://dx.doi.org/10.1532/hsf.1424.

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<strong>Background:</strong> Renal dysfunction is a common complication after cardiovascular surgery. Controversial issues have been discussed regarding the role of N-acetyl cysteine in the prevention of postoperative renal dysfunction. The purpose of this meta-analysis is to assess whether N-acetyl cysteine offers any protection against the development of acute renal dysfunction after cardiac surgery. <br /><strong>Methods:</strong> Multiple databases were searched for randomized trials comparing the role of N-acetyl cysteine and placebo in human patients undergo
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Dissertations / Theses on the topic "Cysteine, N-acetyl Cysteine"

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KUO, MING-WEN. "ROLE OF N-ACETYL CYSTEINE IN PREVENTING AGE-RELATED HEARING LOSS." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172356377.

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Karalija, Amar. "Diagnostic and therapeutic strategies following spinal cord and brachial plexus injuries." Doctoral thesis, Umeå universitet, Anatomi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127519.

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Traumatic injuries to the spinal cord and brachial plexus induce a significant inflammatory response in the nervous tissue with progressive degeneration of neurons and glial cells, and cause considerable physical and mental suffering in affected patients. This thesis investigates the effects of the antioxidants N-acetyl-cysteine (NAC) and acetyl-L- carnitine (ALC) on the survival of motoneurons in the brainstem and spinal cord, the expression of pro-apoptotic and pro-inflammatory cell markers, axonal sprouting and glial cell reactions after spinal hemisection in adult rats. In addition, a nove
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Cheng, Huiwen. "Effects of N-acetyl-L-cysteine and Nitric Oxide-releasing Nonsteroidal Anti-Inflammatory Drugs on Breast Cancer and Melanoma Cell Adhesion." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1384948906.

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Moore, Thomas B. "The Role of N-acetyl-L-Cysteine (NAC) as an Adjuvant to Opioid Treatment in Patients with Inadequately Controlled Chronic Neuropathic Pain." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4315.

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Introduction. While opioid medications are commonly prescribed for management of neuropathic pain (NP), long-term use has been associated with increased risk for overdose, drug interactions and addiction. New strategies are necessary to better manage chronic pain, thereby reducing need for opioid medications and their associated adverse consequences. N-acetyl-L-cysteine (NAC), an over-the-counter supplement, has shown promise in the treatment of psychiatric and addictive disorders. In addition, NAC has shown promise for reducing physiological signs of NP in laboratory rat models, prompting thi
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Realini, Giulia. "N-acetyl-L-cysteine ethyl ester (NACET) as a potential therapeutic strategy for the prevention and treatment of Age-related Macular Degeneration." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1203143.

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Age-related macular degeneration (AMD) is a multifactorial progressive chronic ocular disease. Genetics, environmental insults, and age-related issues are risk factors for the development of the disease. Dysfunction of retinal pigment epithelium (RPE) is involved in AMD and oxidative stress in RPE is one of the major causes of the etiopathogenesis of AMD. Therefore, the introduction of antioxidants may represent one of the most effective ways to delay the onset of AMD. Glutathione (GSH) is a key player in the detoxification of xenobiotics, their metabolites and of reactive oxygen species (ROS)
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Schenatto, Ricardo Olimpio. "Uso da N-acetil-L-cisteína no resfriamento de sêmen equino." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/181359.

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Este estudo teve como objetivo avaliar o efeito da N-acetil-L-cisteína (NAC), adicionada ao diluente composto de leite em pó desnatado, sobre a viabilidade espermática e o estresse oxidativo do sêmen equino resfriado a 5°C. Ejaculados de 8 pôneis da raça Brasileira foram coletados em triplicata resultando em 24 ejaculados. O sêmen foi distribuído em 4 grupos: Equidil® + 0,00 mM (controle), 0,5 mM, 1,0 mM ou 2,5 mM de NAC. As amostras foram armazenadas em tubos de 15mL e mantidas em caixas de transporte de sêmen BotuFLEX® (Botupharma, Botucatu-SP, Brasil). Parâmetros como motilidade total (MT),
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Kerksick, Chad M. Willoughby Darryn Scott. "Effects of prophylactic supplementation of N-acetyl-cysteine and epigallocatechin gallate on markers of oxidative stress, inflammation and apoptosis after eccentric contraction-induced injury in untrained males." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4881.

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Nocentini, Benedetta. "Indagine su reazioni di sulfa-Michael di interesse in campo cosmetologico e sul trattamento ricostruttore del capello." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15849/.

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The aim of this work was to evaluate the reactivity of cysteinyl residues that can be found in damaged human hair with Michael acceptors under mild conditions and to gain information on the hair modifications occurring in hair bleached and then repaired with some commercial formulations. In some patents, the use of some molecules effective for repairing damaged hair is claimed. Their structure is compatible with the occurrence of Michael addition reactions, and the need of more detailed studies about the reaction mechanism and the effect on human hair of commercial products containing hair reb
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Barbanera, Pedro Octavio. "Estudo do efeito do N-acetil-cisteína através do metabolismo energético, complexos respiratórios e estresse oxidativo no tecido hepático de ratos submetidos ao glutamato monossódico." Botucatu, 2018. http://hdl.handle.net/11449/158323.

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Orientador: Ana Angélica Henrique Fernandes<br>Resumo: A obesidade é considerada um dos maiores problemas de saúde pública em muitos países, uma vez que está associada queda da qualidade de vida. Embora existam vários fatores que corroboram com o desenvolvimento para tal fato, os hábitos alimentares seja o fator relevante. Os transtornos metabólicos podem resultar em alterações na funcionalidade do fígado, podendo desenvolver Doença Hepática Gordurosa Não Alcoólica (DHGNA). Como o número de obesos e as co-morbidades associadas ao sobrepeso vêm aumentando abruptamente nas últimas décadas, vário
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Ibrahim, Marwa Awad Abdel Hamid [Verfasser]. "Immunohistochemical studies of the influence of alkylating substances on the wound healing process and the possible protective role of N-Acetyl Cysteine and Alpha-Linolenic Acid / Marwa Awad Abdel Hamid Ibrahim." Köln : Deutsche Zentralbibliothek für Medizin, 2012. http://d-nb.info/1030211507/34.

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Books on the topic "Cysteine, N-acetyl Cysteine"

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Hitt, Mark Edward. Hepatocellular cytoprotection against the pathobiologic effects of thiacetarsamine in vitro and in vivo using N-acetyl-L-cysteine. National Library of Canada, 1992.

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Hitt, Mark Edward. Hepatocellular cytoprotection against the pathobiologic effects of thiacetarsamine in vitro and in vivo using N-acetyl-L-cysteine. University of Prince Edward Island, 1992.

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Grötz, Knut Achim. Untersuchungen zur biologischen Verwertbarkeit von N-Acetyl-L-Cystein bei der wachsende Ratte unter langfristigen parenteraler Ernährung. [s.n.], 1985.

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Publications, ICON Health. N-Acetyl Cysteine - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References. ICON Health Publications, 2004.

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Buttram, Sandra D. W., and Anne-Michelle Ruha. Toxicological Emergencies. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199918027.003.0017.

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This chapter includes essential information about common toxic exposures requiring pediatric intensive care unit care. Specific agents, grouped into categories, are reviewed, including analgesics (acetaminophen and aspirin), opiates, carbon monoxide, cardiovascular medications (calcium channel antagonists and β‎ blockers), tricyclic antidepressants, sulfonylureas, and toxic alcohols. An overview of each agent followed by clinical presentation, and appropriate diagnostic evaluation and management are provided, including alkalinization with administration of sodium bicarbonate, need for hemodial
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Düsseldorf, Heinrich-Heine-Universität, ed. Enzymaktivität menschlicher Alveolarmakrophagen unter Einwirkung von N-Acetyl-Cystein und Analoga. 1989.

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Darmstadt, Technische Hochschule, ed. Transport- und Entgiftungswege an der Blut-Hirn-Schranke: Reinigung, Charakterisierung und Lokalisation der Cystein-S-Konjugat-spezifischen N-Acetyl-S-Transferase des Schweines. 1995.

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Book chapters on the topic "Cysteine, N-acetyl Cysteine"

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Pannu, Neesh, Xiaoyan Wen, John A. Kellum, et al. "N-Acetyl Cysteine (Renal)." In Encyclopedia of Intensive Care Medicine. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_304.

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Agustí, A. G. N., J. Ibañez, and B. Togores. "Effects of N-Acetyl-Cysteine on Splanchnic Circulation." In Update in Intensive Care and Emergency Medicine. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79715-6_4.

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De Flora, Silvio, Alberto Izzotti, Adriana Albini, Francesco D’Agostini, Maria Bagnasco, and Roumen Balansky. "Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine." In Cancer Chemoprevention. Humana Press, 2004. http://dx.doi.org/10.1007/978-1-59259-767-3_3.

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Sato, Naoko, Takeshi Ueno, Katsutoshi Kubo, et al. "Inhibition of oral fibroblast growth and function by N-acetyl cysteine." In Interface Oral Health Science 2009. Springer Japan, 2010. http://dx.doi.org/10.1007/978-4-431-99644-6_25.

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Olivier, R., O. Lopez, M. Mollereau, T. Dragic, D. Guetard, and L. Montagnier. "Prevention of early cell death in peripheral blood lymphocytes of HIV infected individuals by an anti-oxidant: N-Acetyl-Cysteine." In Oxidative Stress, Cell Activation and Viral Infection. Birkhäuser Basel, 1994. http://dx.doi.org/10.1007/978-3-0348-7424-3_27.

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Abdel-Baky, Rehab Mahmoud, Mohamed Abdullah Ali, Gamal El-Din Ali A. Abuo-Rahma, and Neveen AbdelAziz. "Inhibition of Urease Enzyme Production and some Other Virulence Factors Expression in Proteus mirabilis by N-Acetyl Cysteine and Dipropyl Disulphide." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2017. http://dx.doi.org/10.1007/5584_2016_197.

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Clough, Stephen R. "Cysteine, N-Acetyl-L*." In Encyclopedia of Toxicology. Elsevier, 2005. http://dx.doi.org/10.1016/b0-12-369400-0/00286-6.

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Coricovac, Dorina E., Iulia A. Pinzaru, and Cristina A. Dehelean. "N-acetyl-l-cysteine." In Reference Module in Biomedical Sciences. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-12-824315-2.01155-6.

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Clough, S. R. "Cysteine, N-Acetyl-l." In Encyclopedia of Toxicology. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-386454-3.00485-1.

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Ackert-Bicknell, Cheryl L., Wesley G. Beamer, and Clifford J. Rosen. "N-Acetyl Cysteine Supplementation of Growing Mice." In Nutritional Aspects of Osteoporosis. Elsevier, 2004. http://dx.doi.org/10.1016/b978-012141704-8/50065-9.

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Conference papers on the topic "Cysteine, N-acetyl Cysteine"

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Lin, Chih-Ju, Feng-Chieh Li, Sheng-Shun Wang, Hsuan-Shu Lee, and Chen-Yuan Dong. "In Vivo N-Acetyl Cysteine Reduce Hepatocyte Death by Induced Acetaminophen." In European Conference on Biomedical Optics. OSA, 2011. http://dx.doi.org/10.1364/ecbo.2011.80921l.

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Lin, Chih-Ju, Feng-Chieh Li, Sheng-Shun Wang, Hsuan-Shu Lee, and Chen-Yuan Dong. "In vivo N-acetyl cysteine reduce hepatocyte death by induced acetaminophen." In European Conferences on Biomedical Optics, edited by Ronald Sroka and Lothar D. Lilge. SPIE, 2011. http://dx.doi.org/10.1117/12.889621.

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Longo, Angela, Gianfranco Carotenuto, and Sergio De Nicola. "Synthesis of luminescent gold nano-clusters coated by N-acetyl-L-cysteine." In 2015 IEEE 15th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2015. http://dx.doi.org/10.1109/nano.2015.7388663.

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Brown, Michael D., Matthew T. Hardison, J. E. Blalock, and Patricia L. Jackson. "Inhibition Of Acetylation Of The PMN Chemoattractant Peptide PGP By Carbocysteine And N-Acetyl Cysteine." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2564.

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Dave, B., S. Granados, S. Mitra, and JC Chang. "Abstract P5-03-12: Targeting breast cancer stem cells using the autopahgy inhibitor N-Acetyl cysteine." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p5-03-12.

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Shah, Parth N., Andrew R. Mullen, Ralph J. DeBerardinis, and Carolyn L. Cannon. "Amelioration Of Cytotoxic And Metabolic Effects Of Silver Cations On Respiratory Epithelial Cells By N-Acetyl Cysteine." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3260.

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Gotera Rivera, C. M., C. López Chang, L. De La Dueña, et al. "Effect of N-acetyl cysteine in a patient cohort with severe or very severe COVID-19 pneumonia." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.4675.

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Kim, HR, BM Kim, KA Lee, SH Lee, and KW Kim. "114 N-acetyl-l-cysteine (NAC) controls osteoclastogenesis through regulating th17 differentiation and rankl production in rheumatoid arthritis." In LUPUS 2017 & ACA 2017, (12th International Congress on SLE &, 7th Asian Congress on Autoimmunity). Lupus Foundation of America, 2017. http://dx.doi.org/10.1136/lupus-2017-000215.114.

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Kim, H.-R., K.-A. Lee, and S.-H. Lee. "AB0090 N-ACETYL-L-CYSTEINE (NAC) controls osteoclastogenesis through regulating TH17 differentiation and RANKL production in rheumatoid arthritis." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.1506.

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Budhathoki, P., Y. R. Sedhai, D. B. Shrestha, et al. "N-Acetyl Cysteine with Steroid Versus Steroid Alone in Severe Alcoholic Hepatitis: A Systematic Review and Meta-Analysis." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2579.

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