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Dissertations / Theses on the topic 'Cysteine, N-acetyl Cysteine'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

KUO, MING-WEN. "ROLE OF N-ACETYL CYSTEINE IN PREVENTING AGE-RELATED HEARING LOSS." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172356377.

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Karalija, Amar. "Diagnostic and therapeutic strategies following spinal cord and brachial plexus injuries." Doctoral thesis, Umeå universitet, Anatomi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127519.

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Traumatic injuries to the spinal cord and brachial plexus induce a significant inflammatory response in the nervous tissue with progressive degeneration of neurons and glial cells, and cause considerable physical and mental suffering in affected patients. This thesis investigates the effects of the antioxidants N-acetyl-cysteine (NAC) and acetyl-L- carnitine (ALC) on the survival of motoneurons in the brainstem and spinal cord, the expression of pro-apoptotic and pro-inflammatory cell markers, axonal sprouting and glial cell reactions after spinal hemisection in adult rats. In addition, a nove

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Cheng, Huiwen. "Effects of N-acetyl-L-cysteine and Nitric Oxide-releasing Nonsteroidal Anti-Inflammatory Drugs on Breast Cancer and Melanoma Cell Adhesion." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1384948906.

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4

Moore, Thomas B. "The Role of N-acetyl-L-Cysteine (NAC) as an Adjuvant to Opioid Treatment in Patients with Inadequately Controlled Chronic Neuropathic Pain." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4315.

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Introduction. While opioid medications are commonly prescribed for management of neuropathic pain (NP), long-term use has been associated with increased risk for overdose, drug interactions and addiction. New strategies are necessary to better manage chronic pain, thereby reducing need for opioid medications and their associated adverse consequences. N-acetyl-L-cysteine (NAC), an over-the-counter supplement, has shown promise in the treatment of psychiatric and addictive disorders. In addition, NAC has shown promise for reducing physiological signs of NP in laboratory rat models, prompting thi

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Realini, Giulia. "N-acetyl-L-cysteine ethyl ester (NACET) as a potential therapeutic strategy for the prevention and treatment of Age-related Macular Degeneration." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1203143.

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Age-related macular degeneration (AMD) is a multifactorial progressive chronic ocular disease. Genetics, environmental insults, and age-related issues are risk factors for the development of the disease. Dysfunction of retinal pigment epithelium (RPE) is involved in AMD and oxidative stress in RPE is one of the major causes of the etiopathogenesis of AMD. Therefore, the introduction of antioxidants may represent one of the most effective ways to delay the onset of AMD. Glutathione (GSH) is a key player in the detoxification of xenobiotics, their metabolites and of reactive oxygen species (ROS)

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Schenatto, Ricardo Olimpio. "Uso da N-acetil-L-cisteína no resfriamento de sêmen equino." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/181359.

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Este estudo teve como objetivo avaliar o efeito da N-acetil-L-cisteína (NAC), adicionada ao diluente composto de leite em pó desnatado, sobre a viabilidade espermática e o estresse oxidativo do sêmen equino resfriado a 5°C. Ejaculados de 8 pôneis da raça Brasileira foram coletados em triplicata resultando em 24 ejaculados. O sêmen foi distribuído em 4 grupos: Equidil® + 0,00 mM (controle), 0,5 mM, 1,0 mM ou 2,5 mM de NAC. As amostras foram armazenadas em tubos de 15mL e mantidas em caixas de transporte de sêmen BotuFLEX® (Botupharma, Botucatu-SP, Brasil). Parâmetros como motilidade total (MT),

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7

Kerksick, Chad M. Willoughby Darryn Scott. "Effects of prophylactic supplementation of N-acetyl-cysteine and epigallocatechin gallate on markers of oxidative stress, inflammation and apoptosis after eccentric contraction-induced injury in untrained males." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4881.

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8

Nocentini, Benedetta. "Indagine su reazioni di sulfa-Michael di interesse in campo cosmetologico e sul trattamento ricostruttore del capello." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15849/.

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The aim of this work was to evaluate the reactivity of cysteinyl residues that can be found in damaged human hair with Michael acceptors under mild conditions and to gain information on the hair modifications occurring in hair bleached and then repaired with some commercial formulations. In some patents, the use of some molecules effective for repairing damaged hair is claimed. Their structure is compatible with the occurrence of Michael addition reactions, and the need of more detailed studies about the reaction mechanism and the effect on human hair of commercial products containing hair reb

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9

Barbanera, Pedro Octavio. "Estudo do efeito do N-acetil-cisteína através do metabolismo energético, complexos respiratórios e estresse oxidativo no tecido hepático de ratos submetidos ao glutamato monossódico." Botucatu, 2018. http://hdl.handle.net/11449/158323.

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Orientador: Ana Angélica Henrique Fernandes<br>Resumo: A obesidade é considerada um dos maiores problemas de saúde pública em muitos países, uma vez que está associada queda da qualidade de vida. Embora existam vários fatores que corroboram com o desenvolvimento para tal fato, os hábitos alimentares seja o fator relevante. Os transtornos metabólicos podem resultar em alterações na funcionalidade do fígado, podendo desenvolver Doença Hepática Gordurosa Não Alcoólica (DHGNA). Como o número de obesos e as co-morbidades associadas ao sobrepeso vêm aumentando abruptamente nas últimas décadas, vário

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10

Ibrahim, Marwa Awad Abdel Hamid [Verfasser]. "Immunohistochemical studies of the influence of alkylating substances on the wound healing process and the possible protective role of N-Acetyl Cysteine and Alpha-Linolenic Acid / Marwa Awad Abdel Hamid Ibrahim." Köln : Deutsche Zentralbibliothek für Medizin, 2012. http://d-nb.info/1030211507/34.

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11

Muranaka, Lígia Segatto. "Mecanismos envolvidos com a sobrevivência de Xylella fastidiosa em condições de estresse e efeito de N-Acetil-L-Cisteína em seu biofilme." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316427.

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Orientadores: Alessandra Alves de Souza, Marco Aurélio Takita<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-16T03:21:51Z (GMT). No. of bitstreams: 1 Muranaka_LigiaSegatto_M.pdf: 4670725 bytes, checksum: f903ecd21649fe431b36cd1ea62d804b (MD5) Previous issue date: 2010<br>Resumo: Xylella fastidiosa é uma bactéria Gram-negativa que causa várias doenças em diferentes espécies de plantas, como a clorose variegada dos citros (CVC) em Citrus sinensis, cujos danos econômicos são da ordem de milhões de dólares anuais. O des

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Möller, Marisa. "Behavioural, neurochemical, inflammatory and mitichondrial markers following social isolation rearing in rats before and after selected deug intervention / Marisa Möller." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9524.

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Purpose: Schizophrenia is a progressive degenerative illness that has been causally linked to mitochondrial dysfunction, oxidative stress and a pro-inflammatory state. Social isolation rearing (SIR) in rats models the neurodevelopmental aspects of schizophrenia. The antioxidant and glutamate modulator, N-acetyl cysteine (NAC), has demonstrated therapeutic potential in schizophrenia as adjunctive treatment, although this has not been tested in the SIR model. The purpose of this study was to assess whether SIR induces changes in mitochondrial function (adenosine triphosphate (ATP)), pro- vs. ant

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13

Schroeder, Ilka Elizma. "A mechanistic study of organochlorine hepatotoxicity." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/24882.

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Pentachlorophenol, (PCP) is an organochlorine compound which was first developed in the 1930’s. PCP is said to be the most toxic of the chlorophenols and is classified as a hazardous substance and a probable human carcinogen. PCP has proven to be cytotoxic to a number of cell lines translating to its effect on various organs. The aim of the study was to assess organochlorine-induced hepatotoxicity in a mechanistic manner using an in-house developed procedure. Also, the possible hepatoprotective effect of methanolic extracts of the bark of two medicinal plants, Burkea africana (BA) and Syzygium

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14

McKay, Hart Andrew. "Sensory neuronal protection & improving regeneration after peripheral nerve injury." Doctoral thesis, Umeå universitet, Handkirurgi, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52.

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Peripheral nerve trauma is a common cause of considerable functional morbidity, and healthcare expenditure. Particularly in the ~15% of injuries unsuitable for primary repair, standard clinical management results in inadequate sensory restitution in the majority of cases, despite the rigorous application of complex microsurgical techniques. This can largely be explained by the failure of surgical management to adequately address the neurobiological hurdles to optimal regeneration. Most significant of these is the extensive sensory neuronal death that follows injury, and which is accompanied by

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15

Selvin, David. "Regulation of Myoplasmic Ca2+ During Fatigue in KATP Channel Deficient FDB Muscle Fibres." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26174.

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It is known that muscles that lack KATP channel activity generate much greater unstimulated [Ca2+]i and force than normal muscles during fatigue. The increase in unstimulated force in KATP channel deficient muscles is abolished by a partial inhibition of L-type Ca2+ channels, suggesting that it is due to a Ca2+ influx through L-type Ca2+ channels and a subsequent increased myoplasmic Ca2+. However, there is also evidence that the increase in resting force is abolished by NAC, a ROS scavenger. The objective of this study was to reconcile these observations by studying the hypothesis that “the i

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16

Pournara, Panagiota [Verfasser]. "Untersuchungen zur Toxikokinetik von Acrylamid und seiner Metabolite N-acetyl-S-(2-carbamoyl-ethyl)-cystein und N-acetyl-S-(2-carbamoyl-2-hydroxy-ethyl)-cystein nach oraler Aufnahme acrylamidhaltiger Nahrung / Panagiota Pournara." Köln : Deutsche Zentralbibliothek für Medizin, 2010. http://d-nb.info/1005360065/34.

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17

Liu, Chen-Wang, and 劉振旺. "Protective Effects of Garlic Water-soluble Compound N-Acetyl-Cysteine on Leukemia Mice." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/30537179967780275759.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>104<br>N-Acetyl-cysteine (NAC) is an acetylated variant of the amino acid L-cysteine, is an effective antioxidant which can protect cells against oxidative stress. However, the possible protective roles of N-Acetyl-cysteine in WEHI-3-induced leukemia mice has never investigated. The protective activity of NAC on WEHI-3-induced leukemia mice was examined. Twelve BALB/c mice weighing 20g were randomly divided into three groups as follows: the first group was injected PBS and served as the control group; the second group was injected WEHI-3 leukemia cells; the third gr

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18

Lai, Yung-Chieh, and 雷詠捷. "Synthesis and preparation the N-Acetyl-L-cysteine based nanogel as the drug carrier." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/ny4343.

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碩士<br>國立東華大學<br>生命科學系<br>102<br>N-Acetyl-L-cysteine (NAC), a scavenger for active oxygen,exhibits anti-inflammatory effect .It contains multiple disulfide bonds synthesized to degrade after delivery of drug into the cell.It can also simultaneously act as glutathione (GSH) precursor. New carriers for triggered intracellular were investigated due to in cellular defense anti oxidative damage. 1,6-Diaminohexane was used for the synthesis of organic compounds, because the polymer compound aggregates. The purpose of this study is to design the drug delivery system by using N-Acetyl-L-cysteine（NAC）an

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19

Hung-Hsuan and 鄭弘萱. "Effect of N-acetyl cysteine on curcumin inhibiting telomerase activity in A549 lung carcinoma cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/27938455440244923109.

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碩士<br>中山醫學大學<br>醫學分子毒理學研究所<br>97<br>Telomerase is a special ribonucleoprotein for synthesizing the telomeric DNA at the ends of chromosomes. Telomerase activity is suppressed in normal human somatic tissues, but it is activated in 85~90% tumor tissues. So inhibiting telomerase activity is a useful therapeutic strategy. Curcumin, the yellow pigment in turmeric, is known to inhibit proliferation of cancer cells by arresting them at various phases of the cell cycle and to induce apoptosis in tumor cells. This study mainly explored that curcumin suppress telomerase activity throuh ROS production i

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20

Phong, Ying-Chiann, and 馮瑩茜. "Effects of N-acetyl cysteine on Lateral Line Hair Cell of Zebrafish Larvae (Danio Rerio)." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/3v3686.

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碩士<br>國立臺灣師範大學<br>生命科學系<br>107<br>N-acetyl cysteine (NAC), an antioxidant used as a nutritional supplement, was used to protect tilapia from oxidative stress-induced by Microcystin and Cylindrospermopsin in the aquaculture sector. The aim of the present study was to investigate the potential toxicity and lethal dose of NAC before applying it to be an antioxidant in fish. Furthermore, we test for the protective effect of NAC against neomycin-induced ototoxicity. We investigate the embryonic toxicity of NAC on zebrafish larvae by acute or chronic exposure to NAC. Our results showed that NAC caus

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Huang, Szu-Ping, and 黃思萍. "An exposure biomarker of aristolochic acid-containing herbs: aristolochic acid and N-acetyl-L-cysteine adduct." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/6ewhgk.

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22

Ying, Chang Wen, and 張文茵. "To Determine the Effects of N-Acetyl Cysteine on the Expression of Thrombomodulin in Breast Cancer." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/58226706533223122427.

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碩士<br>國防醫學院<br>生物化學研究所<br>103<br>Reactive oxygen species (ROS) can cause cellular injury by inducing DNA damages which can lead to tumorgenesis. So far, the evidences show that antioxidants can neutralize ROS thereby reducing cell damages. Many studies have found that ROS can promote Epithelial-mesenchymal transition (EMT) of cancer cells, in which can promote cancer metastasis and invasiveness. In addition, the majority of antioxidants are also found to have the effects of prevention or inhibition of EMT. Lots of proteins are known to participate in the EMT process such as Thrombomomodulin (T

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23

Chen, Jia-Shing, and 陳嘉興. "Inhibitory Effects of N-acetyl-L-cysteine on Cell Proliferation and UV Induction of PCNA in CHO-K1 Cells." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/17276217244298459314.

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碩士<br>國立清華大學<br>生命科學系<br>88<br>N-acetyl-L-cysteine (NAC), a well-known antioxidant is a scavenger of free radicals that can remove excess free radicals from cells and protect cells from damage by oxidants. In cycling CHO-K1 cells, NAC can inhibit the proliferation of cells, delay the procession of cell cycle and change the morphology of cells. When the cells are treated by NAC, the morphology of cells changes from normal spindle to abnormal round gradually. But we can''t find the morphology change on quiescent cells. When the medium containing NAC is removed, cell cycle will go ahead and the c

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24

Chung, Li-Yu, and 鍾麗玉. "Oxidative damage caused by infection with Angiostrongylus cantonensis and the mechanism in the treatment with N-acetyl-L-cysteine." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/94745979984818638233.

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博士<br>高雄醫學大學<br>醫學研究所<br>99<br>This study included three aims. The first aim was to estimate reactive oxygen species (ROS) production, antioxidants activity, and biomarkers level of oxidative damage to lipid, protein and DNA in the cerebrospinal fluid (CSF) of C57BL/6 mice infected with Angiostrongylus cantonensis. The ROS concentration in the CSF of infected mice increased gradually, and the increase in ROS in CSF became statistical significance at day 12-30 post-infection compared to that before infection, and then ROS returned to normal level at day 45 after infection. In parallel with

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25

Liu, Tzu-An, and 劉子安. "Electrochemical Determination of N-acetyl-L-cysteine at Poly(3,4-ethylenedioxythiophene) and Ionic Liquid Composite Film Modified Screen-Printed Carbon Electrodes." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/9pfdf5.

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碩士<br>國立暨南國際大學<br>應用化學系<br>102<br>In this study, we modified a thin layer of poly-3,4-ethylenedioxythiophene (PEDOT) on a bare screen-printed carbon electrode (SPCE) by electrochemical methods, and then ionic liquid ([BMIM+][Cl-]) was fabricated onto SPCE/PEDOT by spin coating. The obtained SPCE/PEDOT/[BMIM+][Cl-] was employed for the determination of N-Acetyl-L-cystenine (NAC) in pH 7.0 buffer. Cyclic voltammetric studies showed two irreversible oxidation potential of NAC at 0.17 V and 0.49 V. It was suggested that the ionic liquid layer can extract NAC and thus lowered overpotentials. The ot

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26

BELLISARIO, VERONICA. "Long-term effects of prenatal exposure to high-fat diet in an animal model of reduced oxidative stress." Doctoral thesis, 2014. http://hdl.handle.net/2158/949357.

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Obesity is a world-wide health problem. The increasing incidence of this pathology among women of reproductive age and children highlights the main question of the role played by maternal obesity in setting up a state of individual susceptibility to metabolic disorders in the adult offspring. A growing body of evidence suggests that maternal obesity and maternal adiposity, per se, are associated with adverse acute maternal and neonatal outcomes. It has been stated that maternal obesity and, more in general, maternal over-nutrition, such as maternal feeding a diet rich in fats (high-fat diet -

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27

Li, Cheng-Feng, and 李承峰. "Regulation of the PI3K/AKT Signaling Pathway by Advanced Glycation End-products, High Glucose and N-acetyl-L-cysteine in 3T3-L1 Preadipocytes." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/93017652716385956940.

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28

Kashyap, Srishti. "Isolation, Structure Elucidation and Functional Characterization of a Novel Cytotoxic Secondary Metabolite Phomafuranone, 2-Hydroxy-2, 4-dimethyl-5-[-1-propen-1-yl]-3(2H)-furanone, from Phoma tropica an Endophytic Fungus Isolated from Mappia foetida." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4135.

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Cancer has become the leading disease-related cause of death in the human population. For example, in the United States, cancer is the second leading cause of death behind cardiovascular disease, and it is projected that cancer will become the leading cause of death in the coming years. The medical treatment of cancer still has many unmet needs. The main curative therapies for cancer, surgery and radiation, are generally only successful if the cancer is found at an early localized stage. Once cancer has progressed to metastatic stage, these therapies are less successful. Hence, chemotherapeuti

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29

Kraus, Torsten. "Entgiftung lipophiler Xenobiotika - die Cystein-S-Konjugat-spezifische N-Acetyl-S-Transferase." Phd thesis, 2000. http://tuprints.ulb.tu-darmstadt.de/58/1/Kraus_Tor.pdf.

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Lebewesen, wie auch der Mensch, sind in der Natur einer Vielzahl von schädlichen Substanzen ausgesetzt. Zum einen sind Schadsubstanzen natürlichen Ursprungs, zum anderen gelangen sie aufgrund anthropogener Wirkungen in die Biosphäre. Gegenüber organischen niedermolekularen Substanzen, die nicht für das Überleben des Organismus notwendig sind, wurden im Laufe der Evolution Mechanismen entwickelt, eine in den Körper aufgenommene Verbindung auszuschleusen. Häufig handelt es sich dabei um potentiell schädliche Chemikalien. Die Entgiftung lipophiler Fremdsubstanzen (Xenobiotika) kann in drei Phasen

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30

Kraus, Torsten [Verfasser]. "Entgiftung lipophiler Xenobiotika - die Cystein-S-Konjugat-spezifische N-Acetyl-S-Transferase : ein repräsentatives Enzym des Mercaptursäureweges / von Torsten Kraus." 1999. http://d-nb.info/960529950/34.

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31

Shee, Somnath. "Manipulating Bacterial and Host Reactive Oxygen Species (ROS)- based mechanisms to potentiate killing of Mycobacterium tuberculosis (Mtb)." Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5680.

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Mycobacterium tuberculosis (Mtb) is evolutionarily equipped to resist exogenous reactive oxygen species but shows vulnerability to an increase in endogenous ROS (eROS). Since eROS is an unavoidable consequence of aerobic metabolism, understanding how eROS levels are controlled is essential yet remains uncharacterized. By combining the Mrx1-roGFP2 redox biosensor with transposon mutagenesis, we identified 368 genes (redoxosome) responsible for maintaining non-toxic levels of eROS in Mtb. Integrating redoxosome with a global network of protein-protein interactions and transcriptional regulators

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