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Journal articles on the topic 'Cysteine, N-acetyl Cysteine'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Mikołajczyk, Oskar, Aleksandra Suchołbiak, Aleksander Małachowski, et al. "Expanding Horizons – A Broad-Spectrum Review of Emerging Medical Applications of N-Acetylcysteine." Quality in Sport 43 (July 9, 2025): 62333. https://doi.org/10.12775/qs.2025.43.62333.

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N-acetyl-l-cysteine is a thiol-containing compound widely recognized for its antioxidant, mucolytic, and glutathione-replenishing properties. Historically established for use in acetaminophen toxicity and respiratory diseases, n-acetyl-l-cysteine has garnered growing interest for its broad therapeutic potential across diverse medical domains. This narrative review synthesizes evidence from meta-analyses published from January 2024 onwards, sourced from PubMed, to present emerging clinical applications of n-acetyl-l-cysteine. Findings suggest promising roles for n-acetyl-l-cysteine as an adjunc

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Martínez-Banaclocha, Marcos. "N-acetyl-cysteine in Schizophrenia: Potential Role on the Sensitive Cysteine Proteome." Current Medicinal Chemistry 27, no. 37 (2020): 6424–39. http://dx.doi.org/10.2174/0929867326666191015091346.

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Background: N-acetyl-cysteine (NAC) has shown widespread utility in different psychiatric disorders, including a beneficial role in schizophrenic patients. Although the replenishment of glutathione and the antioxidant activity of NAC have been suggested as the mechanisms that improve such a wide range of disorders, no one seems to be sufficiently specific to explain these intriguing effects. A sensitive cysteine proteome is emerging as a functional and structural network of interconnected sensitive cysteine-containing proteins (SCCPs) that together with reactive species and the cysteine/glutat

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3

De Vries, Nico, and Silvio De Flora. "N-acetyl-l-cysteine." Journal of Cellular Biochemistry 53, S17F (1993): 270–77. http://dx.doi.org/10.1002/jcb.240531040.

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4

Park, Taehoon, Ju-Hee Oh, Joo Hyun Lee, Sang Park, Young Jang, and Young-Joo Lee. "Oral Administration of (S)-Allyl-l-Cysteine and Aged Garlic Extract to Rats: Determination of Metabolites and Their Pharmacokinetics." Planta Medica 83, no. 17 (2017): 1351–60. http://dx.doi.org/10.1055/s-0043-111895.

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Abstract(S)-Allyl-l-cysteine is the major bioactive compound in garlic. (S)-Allyl-l-cysteine is metabolized to (S)-allyl-l-cysteine sulfoxide, N-acetyl-(S)-allyl-l-cysteine, and N-acetyl-(S)-allyl-l-cysteine sulfoxide after oral administration. An accurate LC-MS/MS method was developed and validated for the simultaneous quantification of (S)-allyl-l-cysteine and its metabolites in rat plasma, and the feasibility of using it in pharmacokinetic studies was tested. The analytes were quantified by multiple reaction monitoring using an atmospheric pressure ionization mass spectrometer. Because sign

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5

Hickman, RJS, BJ Christie, RW Guy, and TJ White. "Synthesis of Aromatic S-Sustituted Derivatives of N-Acetyl-L-cysteine." Australian Journal of Chemistry 38, no. 6 (1985): 899. http://dx.doi.org/10.1071/ch9850899.

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A new method for the preparation of aromatic, S-substituted derivatives of N-acetyl-L- cysteine is described. The method involves nucleophilic substitution of aromatic iodides by N-acetyl-L- cysteine in the presence of copper(I) iodide, and provides the first example of nucleophilic substitution of unactivated aromatic halides by N-acetyl-L- cysteine . The method has been used to prepare N-acetyl-S-(2-thienyl)-L- cysteine and N-acetyl-S-(3-thienyl)-L- cysteine from 2-iodothiophen and 3-iodothiophen respectively. In addition, the method has been successfully applied to iodobenzene and 1-iodonap

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Makarov, Sergei V., Elizaveta A. Pokrovskaya, Denis S. Salnikov, and Anastasiya V. Amanova. "INFLUENCE OF L-CYSTEINE AND N-ACETYL-L-CYSTEINE ON REDUCING ACTIVITY OF THIOUREA DIOXIDE IN AQUEOUS SOLUTIONS." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 63, no. 10 (2020): 4–10. http://dx.doi.org/10.6060/ivkkt.20206310.6257.

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The influence of L-cysteine and N-acetyl-L-cysteine on the stability and reducing activity of thiourea dioxide (NH2)2CSO2 (TDO) in the reaction with azo dye Orange II has been studied. The addition of L-cysteine and N-acetyl-L-cysteine leads to the increase in reducing activity of TDO in weakly acidic, neutral and weakly alkaline solutions, but does not influence its reducing activity in strongly alkaline solutions. In alkaline solutions, the rate of reduction of Orange II is increasing, but the influence of additives of thiol acids is decreasing. The activating effect of N-ace-tyl-L-cysteine

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7

Kandiş, Hayati, Melih Engin Erkan, Ümran Yildirim, et al. "Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication." Human & Experimental Toxicology 30, no. 9 (2010): 1350–58. http://dx.doi.org/10.1177/0960327110391384.

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Aim: The aim of the present study was to investigate the therapeutic and preventive effects of N-acetyl cysteine and erdosteine on renal injury associated with paracetamol (acetaminophen) intoxication. Materials and methods: Female albino Wistar rats were divided into six groups: control; paracetamol (1 g/kg, oral); paracetamol (1 g/kg, oral) + erdosteine (150 mg/kg/day, oral); paracetamol (1 g/kg, oral) + N-acetyl cysteine (140 mg/kg bolus, followed by 70 mg/kg, oral); N-acetyl cysteine control (140 mg/kg bolus, followed by 70 mg/kg, oral); and erdosteine control (150 mg/kg/day, oral). Potent

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8

Martinez-Banaclocha, Marcos A. "Targeting the Cysteine Redox Proteome in Parkinson’s Disease: The Role of Glutathione Precursors and Beyond." Antioxidants 12, no. 7 (2023): 1373. http://dx.doi.org/10.3390/antiox12071373.

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Encouraging recent data on the molecular pathways underlying aging have identified variants and expansions of genes associated with DNA replication and repair, telomere and stem cell maintenance, regulation of the redox microenvironment, and intercellular communication. In addition, cell rejuvenation requires silencing some transcription factors and the activation of pluripotency, indicating that hidden molecular networks must integrate and synchronize all these cellular mechanisms. Therefore, in addition to gene sequence expansions and variations associated with senescence, the optimization o

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9

Uttamsingh, Vinita, D. A. Keller, and M. W. Anders. "Acylase I-Catalyzed Deacetylation ofN-Acetyl-l-cysteine andS-Alkyl-N-acetyl-l-cysteines‡." Chemical Research in Toxicology 11, no. 7 (1998): 800–809. http://dx.doi.org/10.1021/tx980018b.

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10

Rababa’h, Abeer M., Salil V. Deo, Salah E. Altarabsheh, et al. "N-Acetyl Cysteine Therapy Does Not Prevent Renal Failure in High-Risk Patients Undergoing Open-Heart Surgery." Heart Surgery Forum 19, no. 1 (2016): 016. http://dx.doi.org/10.1532/hsf.1424.

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<strong>Background:</strong> Renal dysfunction is a common complication after cardiovascular surgery. Controversial issues have been discussed regarding the role of N-acetyl cysteine in the prevention of postoperative renal dysfunction. The purpose of this meta-analysis is to assess whether N-acetyl cysteine offers any protection against the development of acute renal dysfunction after cardiac surgery. <br /><strong>Methods:</strong> Multiple databases were searched for randomized trials comparing the role of N-acetyl cysteine and placebo in human patients undergo

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Somdas, Mehmet Akif, Inayet Gunturk, Deniz Avci, et al. "N-Acetyl Cysteine Reduces Cisplatin Ototoxicity." Erciyes Tıp Dergisi/Erciyes Medical Journal 38, no. 3 (2016): 111–14. http://dx.doi.org/10.5152/etd.2016.0068.

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12

Mohamed, Zubair Umer, Lakshmi Krishnakumar, and Surendran Sudhindran. "N-acetyl cysteine in liver resection." Journal of Surgical Oncology 114, no. 6 (2016): 773. http://dx.doi.org/10.1002/jso.24389.

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13

Khayyat, Ahdab, Weili Fan, Shakila Tobwala, and Nuran Ercal. "Comparative Evaluation Between N-Acetyl Cysteine and N-Acetyl Cysteine Amide in Acetaminophen-Induced Oxidative Stress." Free Radical Biology and Medicine 53 (November 2012): S108. http://dx.doi.org/10.1016/j.freeradbiomed.2012.10.260.

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14

Mullier, Emeline, Timo Roine, Alessandra Griffa, et al. "N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study." International Journal of Neuropsychopharmacology 22, no. 8 (2019): 478–87. http://dx.doi.org/10.1093/ijnp/pyz022.

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Abstract Background There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment of oligodendrocytes and parvalbumin interneurons, may underlie brain connectivity alterations in schizophrenia. Accordingly, we previously reported that levels of brain antioxidant glutathione in the medial prefrontal cortex were positively correlated with increased functional connectivity along the cingulum bundle in healthy controls but not in early psychosis patients. In a recent randomized controlled trial, we observed that 6-month supplementation with

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15

Martinez-Banaclocha, Marcos. "N-Acetyl-Cysteine: Modulating the Cysteine Redox Proteome in Neurodegenerative Diseases." Antioxidants 11, no. 2 (2022): 416. http://dx.doi.org/10.3390/antiox11020416.

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In the last twenty years, significant progress in understanding the pathophysiology of age-associated neurodegenerative diseases has been made. However, the prevention and treatment of these diseases remain without clinically significant therapeutic advancement. While we still hope for some potential genetic therapeutic approaches, the current reality is far from substantial progress. With this state of the issue, emphasis should be placed on early diagnosis and prompt intervention in patients with increased risk of neurodegenerative diseases to slow down their progression, poor prognosis, and

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16

Kurtina, Daria A., Valeria P. Grafova, Irina S. Vasil’eva, Sergey V. Maksimov, Vladimir B. Zaytsev, and Roman B. Vasiliev. "Induction of Chirality in Atomically Thin ZnSe and CdSe Nanoplatelets: Strengthening of Circular Dichroism via Different Coordination of Cysteine-Based Ligands on an Ultimate Thin Semiconductor Core." Materials 16, no. 3 (2023): 1073. http://dx.doi.org/10.3390/ma16031073.

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Chiral nanostructures exhibiting different absorption of right- and left-handed circularly polarized light are of rapidly growing interest due to their potential applications in various fields. Here, we have studied the induction of chirality in atomically thin (0.6–1.2 nm thick) ZnSe and CdSe nanoplatelets grown by a colloidal method and coated with L-cysteine and N-acetyl-L-cysteine ligands. We conducted an analysis of the optical and chiroptical properties of atomically thin ZnSe and CdSe nanoplatelets, which was supplemented by a detailed analysis of the composition and coordination of lig

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17

Moreno-Ortega, Alicia, Gema Pereira-Caro, Iziar A. Ludwig, María-José Motilva, and José Manuel Moreno-Rojas. "Bioavailability of Organosulfur Compounds after the Ingestion of Black Garlic by Healthy Humans." Antioxidants 12, no. 4 (2023): 925. http://dx.doi.org/10.3390/antiox12040925.

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The consumption of black garlic has been related to a decreased risk of many human diseases due to the presence of phytochemicals such as organosulfur compounds (OSCs). However, information on the metabolization of these compounds in humans is limited. By means of ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS), this study aims to determine the OSCs and their metabolites excreted in urine 24 h after an acute intake of 20 g of black garlic by healthy humans. Thirty-three OSCs were identified and quantified, methiin (17,954 ± 6040 nmol), i

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18

Dean, Olivia M., Kylie M. Gray, Kristi-Ann Villagonzalo, et al. "A randomised, double blind, placebo-controlled trial of a fixed dose of N-acetyl cysteine in children with autistic disorder." Australian & New Zealand Journal of Psychiatry 51, no. 3 (2016): 241–49. http://dx.doi.org/10.1177/0004867416652735.

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Objective: Oxidative stress, inflammation and heavy metals have been implicated in the aetiology of autistic disorder. N-acetyl cysteine has been shown to modulate these pathways, providing a rationale to trial N-acetyl cysteine for autistic disorder. There are now two published pilot studies suggesting efficacy, particularly in symptoms of irritability. This study aimed to explore if N-acetyl cysteine is a useful treatment for autistic disorder. Method: This was a placebo-controlled, randomised clinical trial of 500 mg/day oral N-acetyl cysteine over 6 months, in addition to treatment as usua

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HASNE, Marie-Pierre, and Françoise LAWRENCE. "Characterization of prenylated protein methyltransferase in Leishmania." Biochemical Journal 342, no. 3 (1999): 513–18. http://dx.doi.org/10.1042/bj3420513.

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Prenylated protein methyltransferase, an enzyme involved in the post-translational modification of many signalling proteins, has been characterized in a parasitic flagellated protozoan, Leishmania donovani. The activity of this enzyme was monitored by the methylation of an artificial substrate, an S-prenylated cysteine analogue, with S-adenosyl-L-[methyl-3H]methionine as methyl donor. More than 85% of the methyltransferase activity was associated with membranes. The enzyme methylates N-acetyl-S-trans,trans-farnesyl-L-cysteine and N-acetyl-S-all-trans-geranylgeranyl-L-cysteine, but N-acetyl-S-t

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MM, Aleemuddin, Raheem Fatima, Mohsin, and Ashfaq Hasan. "N-Acetyl Cysteine in treatment of COPD." IP Indian Journal of Immunology and Respiratory Medicine 3, no. 3 (2018): 137–46. http://dx.doi.org/10.18231/2581-4222.2018.0035.

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21

DiMari, J., J. Megyesi, N. Udvarhelyi, P. Price, R. Davis, and R. Safirstein. "N-acetyl cysteine ameliorates ischemic renal failure." American Journal of Physiology-Renal Physiology 272, no. 3 (1997): F292—F298. http://dx.doi.org/10.1152/ajprenal.1997.272.3.f292.

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Recovery from ischemic renal injury is accompanied by enhanced DNA synthesis and a typical immediate early (IE) gene response. These two processes occur in distinct cell populations, suggesting that the IE gene response does not serve a proliferative function directly. As cellular stress induces an IE response through activation of the stress-activated protein kinases (SAPK) that is not proliferative and can be inhibited by N-acetyl-L-cysteine (NAC), we determined whether the Jun NH2-terminal kinases (JNK), members of the SAPKs, are activated during ischemia and whether NAC administration redu

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22

Pérez, María Florencia, Juan Manuel Pérez, and Joaquín Pérez. "N-acetyl Cysteine and Post-infarction Remodeling." Revista Argentina de Cardiologia 92, no. 2 (2024): 170–71. http://dx.doi.org/10.7775/rac.v92.i2.20763.

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23

Dilger, R. N., and D. H. Baker. "Oral N-acetyl-l-cysteine is a safe and effective precursor of cysteine1." Journal of Animal Science 85, no. 7 (2007): 1712–18. http://dx.doi.org/10.2527/jas.2006-835.

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24

Duvanova, O. V., B. N. Mishankin, S. V. Titova, and L. A. Korneeva. "THE EFFECT OF N-ACETYL-L-CYSTEINE ON BIOFILM OF VIBRIO CHOLERAE." Journal of microbiology epidemiology immunobiology, no. 2 (April 28, 2018): 83–87. http://dx.doi.org/10.36233/0372-9311-2018-2-83-87.

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Aim. To study the effect of N-acetyl-L-cysteine on biofilm of V. cholerae of different sero-groups isolated from various sources and with different epidemiological significance (the presence/ absence of the ctx AB genes and tcpA). Materials and methods. Bacterial eiiltiire of Vibrio cholerae El Tor O1 and O139 serogroups were grown as biolms. We have estimated the influence of the drug N-acetyl-L-cysteine at a concentration of 0.5 - 4 mg/ml on the formation, of the formed biofilm and in planktonic form. Results. Discovered antibacterial activity of N-acetyl-L-cysteine. Noted that it was influe

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Singh, Thiyam Samrat, and Thiyam David Singh. "Optical Absorption, Kinetics and Thermodynamic Studies of Pr(III) and Nd(III) Ions with N-Acetyl L-Cysteine in Presence of Ca(II) ions." Asian Journal of Chemistry 34, no. 2 (2022): 272–78. http://dx.doi.org/10.14233/ajchem.2022.23475.

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Interaction of N-acetyl-L-cysteine (NAC) with Pr3+ (Pr(NO3)3·6H2O) and Nd3+ (Nd(NO3)3·6H2O) ions are studied in presence of Ca2+ (Ca(NO3)3·4H2O) ion in an aqueous and organic solvent by applying the spectroscopic technique for quantitative probe of 4f-4f transition. The complexation was determined by the variation in the intensities of 4f-4f absorption spectral bands and by applying the change of symmetric properties of electronic-dipole known as Judd-Ofelt parameters Tλ (λ = 2,4,6). On the addition of Ca2+ ion in the binary complexation of praseodymium and neodymium with N-acetyl-L-cysteine (

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Frigerio, Gianfranco, Laura Campo, Rosa Mercadante, Danuta Mielżyńska-Švach, Sofia Pavanello, and Silvia Fustinoni. "Urinary Mercapturic Acids to Assess Exposure to Benzene and Other Volatile Organic Compounds in Coke Oven Workers." International Journal of Environmental Research and Public Health 17, no. 5 (2020): 1801. http://dx.doi.org/10.3390/ijerph17051801.

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Coke production was classified as carcinogenic to humans by the International Agency for Research on Cancer. Besides polycyclic aromatic hydrocarbons, coke oven workers may be exposed to benzene and other volatile organic compounds (VOCs). The aim of this study was to assess the exposure to several VOCs in 49 coke oven workers and 49 individuals living in the same area by determining urinary mercapturic acids. Active tobacco smoking was an exclusion criterion for both groups. Mercapturic acids were investigated by a validated isotopic dilution LC-MS/MS method. Linear models were built to corre

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Rostron, Brian L., Jia Wang, Arash Etemadi, et al. "Associations between Biomarkers of Exposure and Lung Cancer Risk among Exclusive Cigarette Smokers in the Golestan Cohort Study." International Journal of Environmental Research and Public Health 18, no. 14 (2021): 7349. http://dx.doi.org/10.3390/ijerph18147349.

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Biomarkers of tobacco exposure are known to be associated with disease risk but previous studies are limited in number and restricted to certain regions. We conducted a nested case–control study examining baseline levels and subsequent lung cancer incidence among current male exclusive cigarette smokers in the Golestan Cohort Study in Iran. We calculated geometric mean biomarker concentrations for 28 matched cases and 52 controls for the correlation of biomarker levels among controls and for adjusted odds’ ratios (ORs) for lung cancer incidence by biomarker concentration, accounting for demogr

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Orhan, Hilmi, Nico P. E. Vermeulen, Gonul Sahin, and Jan N. M. Commandeur. "Characterization of Thioether Compounds Formed from Alkaline Degradation Products of Enflurane." Anesthesiology 95, no. 1 (2001): 165–75. http://dx.doi.org/10.1097/00000542-200107000-00027.

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Background Renal toxicity has occasionally been observed after enflurane anesthesia. Although originally attributed to its oxidative metabolism to inorganic fluoride, serum levels of inorganic fluoride appear to be small to explain these renal effects. Formation of potentially nephrotoxic halogenated alkenes during alkaline degradation in carbon dioxide absorbers and subsequent bioactivation via the glutathione conjugation pathway may be considered as an alternative mechanism for renal toxicity. The aim of this study was to characterize the thioethers formed chemically and biosynthetically. Me

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Magnusson, Inger, Lars Ekman, Marie Wångdahl, and John Wahren. "N-acetyl-l-tyrosine and N-acetyl-l-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans." Metabolism 38, no. 10 (1989): 957–61. http://dx.doi.org/10.1016/0026-0495(89)90005-x.

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Geschwill, K., and L. Lumper. "Identification of cysteine residues in carbamoyl-phosphate synthase I with reactivity enhanced by N-acetyl-l-glutamate." Biochemical Journal 260, no. 2 (1989): 573–76. http://dx.doi.org/10.1042/bj2600573.

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Carbamoyl-phosphate synthase I (pig liver) is modified at the cysteine residues 1327 and 1337 (numbered according to the rat sequence) in the presence of 5 mM-N-acetyl-L-glutamate with enhanced rate. ATP/Mg2+ (greater than or equal to 5 mM) protects against alkylation of these two cysteines and loss of activity. According to the results obtained by limited proteolysis of monobromobimane-modified carbamoyl-phosphate synthase I, the accessible cysteines 1327 and 1337 are located in the C-terminal 20 kDa domain D of the enzyme. N-Bromoacetyl-L-glutamate is an allosteric activator and inactivates

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Hasan, Md Ashraful, Won-Gyun Ahn, and Dong-Keun Song. "N-acetyl-L-cysteine and cysteine increase intracellular calcium concentration in human neutrophils." Korean Journal of Physiology & Pharmacology 20, no. 5 (2016): 449. http://dx.doi.org/10.4196/kjpp.2016.20.5.449.

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32

Kr̆epela, E., J. Procházka, and B. Kárová. "Tumor chemopreventive agent N-acetyl-l-cysteine inhibits the cysteine protease cathepsin B." Lung Cancer 21 (September 1998): S38. http://dx.doi.org/10.1016/s0169-5002(98)90079-4.

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Martinez‐Banaclocha, Marcos A. "Potential Role of N‐Acetyl‐Cysteine in the Cysteine Proteome in Parkinson's Disease?" Clinical Pharmacology & Therapeutics 107, no. 5 (2019): 1055. http://dx.doi.org/10.1002/cpt.1709.

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Komal, Wajeeha, Shafaq Fatima, Qandeel Minahal, Razia Liaqat, and Aya S. Hussain. "Assessing the effects of N-acetyl cysteine on growth, antioxidant and immune response in tilapia (Oreochromis niloticus) under different regimes of stocking densities." PLOS ONE 19, no. 9 (2024): e0307212. http://dx.doi.org/10.1371/journal.pone.0307212.

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The study investigated the impact of N-acetyl cysteine on growth, immune response, and antioxidant activity in tilapia (Oreochromis niloticus). Fish were reared at three densities (1.50, 3.00, and 4.50 kg/m3) with four levels of N-acetyl cysteine supplementation (0, 2, 4, and 6 mg/kg) over 60 days. Better growth was observed at low density, but at all densities, fish fed the highest N-acetyl cysteine level (6 mg/kg) showed improved growth. Chemical composition of fish and activity of amylase, lipase and protease in all treatments were noted to be insignificant. The levels of antioxidant enzyme

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Yılmaz, Ayşe Mine, Gökhan Biçim, Kübra Toprak, Betül Karademir, and A. Süha Yalçın. "Effects of Different Stress Conditions on Apoptosis, Proteasome Activity and Exosome Cell Death Pathways in Hepatocellular Carcinoma Cells." Proceedings 2, no. 25 (2018): 1532. http://dx.doi.org/10.3390/proceedings2251532.

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In both healthy cells and cancer cells a number of different cellular responses influence the progress of cancer. In this study, we have investigated the effect of stress conditions on human hepatocyte cancer cells. Different concentrations of hydrogen peroxide, quercetin and N-acetyl cysteine were used to induce the acute cell stress. We have detected apoptosis, measured proteasome activity and performed a cell death array in both treated and control cells. Treatment of human hepatocyte cancer cells with hydrogen peroxide and quercetin resulted in decreased cell viability and increased apopto

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Wilde, Paul E., and David G. Upshall. "Cysteine Esters Protect Cultured Rodent Lung Slices from Sulphur Mustard." Human & Experimental Toxicology 13, no. 11 (1994): 743–48. http://dx.doi.org/10.1177/096032719401301102.

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1 In previous studies an in vitro rat lung slice system was used to investigate the metabolic and structural changes after exposure to known lung toxicants. 2 In this study, the same system was used to identify the ability of cysteine esters to protect against sulphur mustard toxicity. 3 The cyclopentyl (CCPE), cyclohexyl (CCHE), isopropyl (CIPE), methyl (CME) esters of cysteine, cystine dimethyl ester (CDME), cysteine (CySH) and N-acetyl cysteine (NAc) were all non-toxic to cultured rat lung slices at 5 mM (equivalent cysteine concentration) after a pretreatment time of 30 min. 4 Pretreatment

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Li, Ruru, Xiaoyu Huang, Guolin Lu, and Chun Feng. "A fluorescence and UV/vis absorption dual-signaling probe with aggregation-induced emission characteristics for specific detection of cysteine." RSC Advances 8, no. 43 (2018): 24346–54. http://dx.doi.org/10.1039/c8ra03756f.

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A dual-signaling of fluorescence and UV/vis absorption modes for selective and quantitative detection of cysteine over homocysteine, N-acetyl-l-cysteine and glutathione is developed on the basis of aggregation-induced emission (AIE) effect.

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Gupta, Veena, Amrita Chaurasia, Shazia Khatoon, and Urvashi Barman Singh. "A study of N-acetyl cysteine, metformin and vitamin D3 with calcium on clinical and metabolic profile in PCOS." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 10 (2017): 4372. http://dx.doi.org/10.18203/2320-1770.ijrcog20174407.

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Background: Polycystic ovarian syndrome (PCOS) is characterized by the combination of hyperandrogenism, chronic anovulation and polycystic ovaries. Objective of present study was to compare the effects of N-acetyl cysteine, metformin and vitamin D3 with calcium on clinical and metabolic profile in PCOS.Methods: 66 women were randomly assigned into three equal treatment groups. Group 1 received N-acetyl cysteine, 600 mg three times a day. Group 2 metformin hydrochloride, 500 mg two times a day for 1 week, then three times a day for rest of the study and Group 3 Vit-D3 60,000 IU weekly with calc

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Giampreti, Andrea, Davide Lonati, Benedetta Ragghianti, et al. "N-Acetyl-Cysteine as Effective and Safe Chelating Agent in Metal-on-Metal Hip-Implanted Patients: Two Cases." Case Reports in Orthopedics 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/8682737.

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Systemic toxicity associated with cobalt (Co) and chromium (Cr) containing metal hip alloy may result in neuropathy, cardiomyopathy, and hypothyroidism. However clinical management concerning chelating therapy is still debated in literature. Here are described two metal-on-metal hip-implanted patients in which N-acetyl-cysteine decreased elevated blood metal levels. A 67-year-old male who underwent Co/Cr hip implant in September 2009 referred to our Poison Control Centre for persisting elevated Co/Cr blood levels (from March 2012 to November 2014). After receiving oral high-dose N-acetyl-cyste

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Li, Qian, and Long-Bo Cui. "Combined inhibitory effects of low temperature and N-acetyl-l-cysteine on the postovulatory aging of mouse oocytes." Zygote 24, no. 2 (2015): 195–205. http://dx.doi.org/10.1017/s0967199415000039.

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SummaryThe postovulatory aging of oocytes eventually affects the development of oocytes and embryos. Oxidative stress is known to accelerate the onset of apoptosis in oocytes and influence their capacity for fertilisation. This study aimed to reveal the roles of temperature and the antioxidant N-acetyl-l-cysteine in preventing the aging of postovulatory mouse oocytes. First, newly ovulated mouse oocytes were cultured at various temperature and time combinations in HCZB medium with varying concentrations of N-acetyl-l-cysteine to assess signs of aging and developmental potential. When cultured

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Wang, Runming, Jasper Fuk-Woo Chan, Suyu Wang, et al. "Orally administered bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy." Chemical Science 13, no. 8 (2022): 2238–48. http://dx.doi.org/10.1039/d1sc04515f.

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A cocktail therapy comprising bismuth drugs and N-acetyl-l-cysteine is reported to suppress the replication of SARS-CoV-2 via the oral route. The broad-spectrum inhibitory activities of the combination upon key viral cysteine enzymes are verified.

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Gunduz, Huseyin. "N-acetyl cysteine therapy in acute viral hepatitis." World Journal of Gastroenterology 9, no. 12 (2003): 2698. http://dx.doi.org/10.3748/wjg.v9.i12.2698.

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Dekhuijzen, P. N., and C. L. Van Herwaarden. "Effect of N-acetyl cysteine on thiol levels." Thorax 50, no. 2 (1995): 215. http://dx.doi.org/10.1136/thx.50.2.215.

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Yamada, M., T. Ueno, H. Minamikawa, et al. "N-acetyl Cysteine Alleviates Cytotoxicity of Bone Substitute." Journal of Dental Research 89, no. 4 (2010): 411–16. http://dx.doi.org/10.1177/0022034510363243.

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Lack of cytocompatibility in bone substitutes impairs healing in surrounding bone. Adverse biological events around biomaterials may be associated with oxidative stress. We hypothesized that a clinically used inorganic bone substitute is cytotoxic to osteoblasts due to oxidative stress and that N-acetyl cysteine (NAC), an antioxidant amino acid derivative, would detoxify such material. Only 20% of rat calvaria osteoblasts were viable when cultured on commercial deproteinized bovine bone particles for 24 hr, whereas this percentage doubled on bone substitute containing NAC. Intracellular ROS le

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França, Katlein, and Torello Lotti. "N-acetyl cysteine in the treatment of trichotillomania." Dermatologic Therapy 30, no. 3 (2016): e12446. http://dx.doi.org/10.1111/dth.12446.

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Gurbuz, Ahmet Kemal, A. Melih Ozel, Ramazan Ozturk, Sukru Yildirim, Yusuf Yazgan, and Levent Demirturk. "Effect of N-Acetyl Cysteine on Helicobacter pylori." Southern Medical Journal 98, no. 11 (2005): 1095–97. http://dx.doi.org/10.1097/01.smj.0000182486.39913.da.

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Huynh, Hien, Richard Lt Couper, Cuong Tran, Azhani Muhamed, and Ross N. Butler. "N-acetyl-cysteine and H. pylori urease activity." Gastroenterology 120, no. 5 (2001): A589. http://dx.doi.org/10.1016/s0016-5085(08)82931-9.

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HUYNH, H., R. COUPER, C. TRAN, A. MUHAMED, and R. BUTLER. "N-acetyl-cysteine and H. pylori urease activity." Gastroenterology 120, no. 5 (2001): A589. http://dx.doi.org/10.1016/s0016-5085(01)82931-0.

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Kilic-Okman, T., and M. Kucuk. "N-acetyl-cysteine treatment for polycystic ovary syndrome." International Journal of Gynecology & Obstetrics 85, no. 3 (2004): 296–97. http://dx.doi.org/10.1016/j.ijgo.2004.03.002.

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Abu Raghif, Ahmed, Yaseen Yaseen, and Muntadher Dawood. "EFFECTS OF N-ACETYL-CYSTEINE (NAC) ADMINISTRATION ON GLUCOSE HOMEOSTASIS PARAMETERS IN PREDIABETIC PATIENTS." Iraqi Journal of Medical Sciences 16, no. 4 (2018): 393–99. http://dx.doi.org/10.22578/ijms.16.4.6.

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Background: Prediabetes is determined on the bases of glycemic parameters, which are above normal but below diabetic thresholds. Prediabetes is associated with the presence of insulin resistance and β-cells dysfunction. N-acetyl cysteine (NAC), as a safe and inexpensive medication, is commercially accessible since long-time ago. This drug is not found in natural sources, although cysteine is present in some meals like chicken and turkey meats, garlic, yogurt, and eggs. NAC prevents apoptosis and oxygen related genotoxicity in endothelial cells by increasing intracellular levels of glutathione

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