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Relevant bibliographies by topics / Cytochrome P450, Parkinson, Oxidative metabolism, CYP induction

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Journal articles
Dissertations / Theses

Academic literature on the topic 'Cytochrome P450, Parkinson, Oxidative metabolism, CYP induction'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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Journal articles on the topic "Cytochrome P450, Parkinson, Oxidative metabolism, CYP induction"

1

Yao, Ping, Liping Hao, Natascha Nussler, et al. "The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage." American Journal of Physiology-Gastrointestinal and Liver Physiology 296, no. 6 (2009): G1318—G1323. http://dx.doi.org/10.1152/ajpgi.00555.2007.

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It has been reported that naturally occurring quercetin exerts hepatoprotective effects through heme oxygenase-1 (HO-1) induction. However, the precise mechanism of how ethanol-associated liver damage is counteracted by quercetin-enhanced HO-1 metabolism still remains unclear. To further decipher the protective role of quercetin on ethanol-induced liver damage, we treated human hepatocytes with quercetin and various (end) products of the HO-1 pathway. Our data clearly showed that quercetin treatment attenuated ethanol-induced damage, whereas hemoglobin and zinc protoporphyrin 9 (ZnPP) abolishe

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2

Bukowska, Bożena, and Piotr Duchnowicz. "Molecular Mechanisms of Action of Selected Substances Involved in the Reduction of Benzo[a]pyrene-Induced Oxidative Stress." Molecules 27, no. 4 (2022): 1379. http://dx.doi.org/10.3390/molecules27041379.

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Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) primarily formed by burning of fossil fuels, wood and other organic materials. BaP as group I carcinogen shows mutagenic and carcinogenic effects. One of the important mechanisms of action of (BaP) is its free radical activity, the effect of which is the induction of oxidative stress in cells. BaP induces oxidative stress through the production of reactive oxygen species (ROS), disturbances of the activity of antioxidant enzymes, and the reduction of the level of non-enzymatic antioxidants as well as of cytokine production. Chemic

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3

Sule, Rasheed O., Christophe Morisseau, Jun Yang, Bruce D. Hammock, and Aldrin V. Gomes. "Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling." Scientific Reports 14, no. 1 (2024). http://dx.doi.org/10.1038/s41598-024-69557-3.

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AbstractOxylipins are a group of bioactive fatty acid metabolites generated via enzymatic oxygenation. They are notably involved in inflammation, pain, vascular tone, hemostasis, thrombosis, immunity, and coagulation. Oxylipins have become the focus of therapeutic intervention since they are implicated in many conditions, such as nonalcoholic fatty liver disease, cardiovascular disease, and aging. The liver plays a crucial role in lipid metabolism and distribution throughout the organism. Long-term exposure to pesticides is suspected to contribute to hepatic carcinogenesis via notable disrupti

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4

Orhan, Hilmi, Ali Ergüç, Fuat Karakuş, Ege Arzuk, and Neliye Mutlu. "Role of Oxidative Stress and Reactive Metabolites in Cytotoxicity & Mitotoxicity of Clozapine, Diclofenac and Nifedipine in CHO-K1 Cells In Vitro." Endocrine, Metabolic & Immune Disorders - Drug Targets 23 (April 19, 2023). http://dx.doi.org/10.2174/1871530323666230419084613.

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Aim: To provide in vitro data on toxicity mechanisms of clozapine, diclofenac and nifedipine. Background: CHO-K1 cells were used as in vitro model to explore mechanisms of cytotoxicity of the test drugs. Objective: Cytotoxic mechanisms of clozapine (CLZ), diclofenac (DIC) and nifedipine (NIF) were studied in CHO-K1 cells in vitro. All three drugs induce adverse reactions in some patients with partially unknown mechanisms. Method: Following the determination of time- and dose-dependency of cytotoxicity by the MTT test, cytoplasmic membrane integrity was explored by the LDH leakage test. Both en

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Dissertations / Theses on the topic "Cytochrome P450, Parkinson, Oxidative metabolism, CYP induction"

1

Chiaino, Elda. "CYP450 expression and regulation in SH-SY5Y cells. Possible role in neurotoxin-mediated injury." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1211396.

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The Cytochrome P450 isozymes involved in xenobiotic metabolism are ubiquitous enzymes, predominantly expressed in the liver in comparison to the extrahepatic tissues. In the brain, CYP expression is approximately 0.5-2% of that in liver microsomes, and most of the isoforms appears to be very low for playing a role in overall total body clearance. Brain basal expression and up-regulation can however significantly affect local disposition of xenobiotic or endogenous compounds. Several reports, in fact, indicate that environmental toxins may play a role in the pathogenesis of neurodegenerative di

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