Academic literature on the topic 'Cytokines producing cells'

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Journal articles on the topic "Cytokines producing cells"

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Kannanganat, Sunil, Chris Ibegbu, Lakshmi Chennareddi, Harriet L. Robinson, and Rama Rao Amara. "Multiple-Cytokine-Producing Antiviral CD4 T Cells Are Functionally Superior to Single-Cytokine-Producing Cells." Journal of Virology 81, no. 16 (2007): 8468–76. http://dx.doi.org/10.1128/jvi.00228-07.

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ABSTRACT Virus-specific CD4 T cells are endowed with multiple functions, such as cytokine production, CD40 ligand (CD40L) expression (associated with the costimulation of CD8 and B cells), and degranulation (associated with cytotoxic potential). Here, we used antiviral CD4 T cells present in human blood to evaluate the relationship between cytokine production and other functions of CD4 T cells. Antiviral CD4 T cells specific for a virus causing persistent infection, cytomegalovirus (CMV), and two viruses causing nonpersistent infections, influenza virus and the smallpox vaccine virus (vaccinia
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Kannanganat, Sunil, Bill G. Kapogiannis, Chris Ibegbu, et al. "Human Immunodeficiency Virus Type 1 Controllers but Not Noncontrollers Maintain CD4 T Cells Coexpressing Three Cytokines." Journal of Virology 81, no. 21 (2007): 12071–76. http://dx.doi.org/10.1128/jvi.01261-07.

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ABSTRACT Here, we evaluate the cytokine coexpression profiles of human immunodeficiency virus (HIV)-specific CD4 T cells for the expression of the cytokines gamma interferon (IFN-γ), interleukin-2, and tumor necrosis factor alpha. In controllers, CD4 T cells producing three or two cytokines (triple producers and double producers, respectively) represented >50% of the total response. In contrast, in noncontrollers ∼75% of responding cells produced only one cytokine (single producers), mostly IFN-γ. Cells producing three cytokines were functionally superior to those producing single cytokines
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Kristensen, Nanna Ny, Andreas Nygaard Madsen, Allan Randrup Thomsen, and Jan Pravsgaard Christensen. "Cytokine production by virus-specific CD8+ T cells varies with activation state and localization, but not with TCR avidity." Journal of General Virology 85, no. 6 (2004): 1703–12. http://dx.doi.org/10.1099/vir.0.79903-0.

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The ability of virus-specific CD8+ T cells to produce cytokines was studied in mice infected with lymphocytic choriomeningitis virus and vesicular stomatitis virus. Intracellular staining was used to visualize cytokine-producing CD8+ and CD4+ T cells. Overall, virus-specific CD8+ T cells produce a similar range of cytokines (IFN-γ, TNF-α, IL-2, GM-CSF, RANTES, MIP-1α and MIP-1β) as CD4+ T cells, but the relative distribution of cytokine-producing subsets is different. Moreover, cytokine-producing CD8+ T cells were found to dominate numerically at all time-points tested. Co-staining for more th
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Wisniewski, Julia A., and Larry Borish. "Novel cytokines and cytokine-producing T cells in allergic disorders." Allergy and Asthma Proceedings 32, no. 2 (2011): 83–94. http://dx.doi.org/10.2500/aap.2011.32.3428.

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Jiang, Yanfang, Zhenhua Ma, Guijie Xin, et al. "Th1 and Th2 Immune Response in Chronic Hepatitis B Patients during a Long-Term Treatment with Adefovir Dipivoxil." Mediators of Inflammation 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/143026.

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Adefovir dipivoxil treatment has significantly improved the outcome of chronic hepatitis B virus (HBV) infection. However, it remains largely unknown how immune system responds to the treatment. Chronic HBV patients were treated with adefovir dipivoxil and examined for serum HBV DNA loads, cytokines, and T helper (Th1) and 2 (Th2) cytokine producing T cells during 104 weeks of the treatment. Th1/Th2 cytokines producing T cells were significantly lower in chronic HBV patients as compared to normal individuals. Adefovir dipivoxil treatment led to the increase of Th1/Th2 cytokines producing T cel
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Souza, Kleber L. A., Ewa Gurgul-Convey, Matthias Elsner, and Sigurd Lenzen. "Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells." Journal of Endocrinology 197, no. 1 (2008): 139–50. http://dx.doi.org/10.1677/joe-07-0638.

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Pro-inflammatory cytokines cause β-cell dysfunction and death. The aim of this study was to investigate the interactions between different pro- and anti-inflammatory cytokines and their effects on apoptotic β-cell death pathways. Insulin-producing RINm5F cells were exposed to different combinations of cytokines. Gene expression analyses of manganese superoxide dismutase (MnSOD) and inducible nitric oxide synthase (iNOS) were performed by real-time RT-PCR. Cell viability was measured by the MTT assay, NFκB activation using a SEAP reporter gene assay, protein expression by western blotting and c
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Webb, LM, and M. Feldmann. "Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells." Blood 86, no. 9 (1995): 3479–86. http://dx.doi.org/10.1182/blood.v86.9.3479.bloodjournal8693479.

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CD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7 costimulatory pathway on development of T helper (Th) subsets. We show that CD28 costimulation is critical for development of the Th2 cytokine-producing cells and that in the absence of CD28 costimulation, cells are not primed to produce Th2 cytokines and consequently “default” to the Th1 subset, independent of the presence of exogenous cytokines. After CD28 costimulation, cells differentiate into a subset that produces Th2 cytokines. However, furt
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Ptackova, Pavlina, Martina Petrackova, Miroslav Hindos, et al. "Intracellular Cytokines Produced by Stimulated CD3+ Cells from Chronic Myeloid Leukemia Patients." Acta Haematologica 137, no. 3 (2017): 148–57. http://dx.doi.org/10.1159/000458703.

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Our work examined the production of intracellular interferon (INF)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-2, and IL-4 by in vitro stimulated CD3+ cells from 38 chronic myeloid leukemia (CML) patients. At the time of diagnosis the percentages of cells producing INF-γ, TNF-α, and IL-2 were strongly suppressed compared to those in healthy control subjects. Hematological remission achieved through treatment with tyrosine-kinase inhibitors was associated with a highly significant increase in the ratio of cells producing all 4 cytokines. The percentages of CD3+ cells producing cytokines
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Lucey, D. R., M. Clerici, and G. M. Shearer. "Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases." Clinical Microbiology Reviews 9, no. 4 (1996): 532–62. http://dx.doi.org/10.1128/cmr.9.4.532.

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In the mid-1980s, Mosmann, Coffman, and their colleagues discovered that murine CD4+ helper T-cell clones could be distinguished by the cytokines they synthesized. The isolation of human Th1 and Th2 clones by Romagnani and coworkers in the early 1990s has led to a large number of reports on the effects of Th1 and Th2 on the human immune system. More recently, cells other than CD4+ T cells, including CD8+ T cells, monocytes, NK cells, B cells, eosinophils, mast cells, basophils, and other cells, have been shown to be capable of producing "Th1" and "Th2" cytokines. In this review, we examine the
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Krause, Günter, Floyd Hassenrück, and Michael Hallek. "Relevant Cytokines in the B Cell Lymphoma Micro-Environment." Cancers 12, no. 9 (2020): 2525. http://dx.doi.org/10.3390/cancers12092525.

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Cytokines are soluble protein factors with importance in intercellular communication and, as such, play pivotal roles in the pathogenesis of B cell malignancies. Evidence from in vitro cultures permitted us to choose example cytokines that bind to different biochemical receptor types. Activated malignant B cells or stromal fibroblasts and macrophages prominently secrete the chemokines CCL3 or CXCL12 and CXCL13, respectively. Apart from helper T cells, various cell types of the B cell lymphoma microenvironment are capable of producing the cytokines IL-4, IL-6, IL-10 and TNFα. Owing to its impac
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Dissertations / Theses on the topic "Cytokines producing cells"

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Hussain, Munther Jaffar. "Role of cytokines in the pathogenesis of type 1 diabetes." Thesis, Brunel University, 1996. http://bura.brunel.ac.uk/handle/2438/3655.

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T lymphocytes and macrophages appear to play an important role in mediating ß-cell damage and causing Type 1 diabetes. Both activated T cells and macrophages operate and interact through the release of soluble factors called cytokines, which influence the type and magnitude of immune responses. It has been suggested that cytokines such as TNF-α and IL-1α can damage the N-cell directly. In Type 1 diabetes, cytokines are likely to have a critical role in individuals whose immune system is unbalanced allowing the emergence of self-destructive processes. To investigate this possibility, sensitive
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Misiak, Jan. "The interactions of stromal cells and follicular helper T cells resulting in a B-cell supporting, IL4-producing phenotype in the context of follicular lymphoma." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B030.

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Un microenvironnement riche en IL-4 a été mis en évidence dans le lymphome folliculaire (FL). Cette IL-4 impliquée dans la croissance tumorale a été démontrée comme principalement secrétée par les lymphocytes T follicular helper (Tfh). Dans cette étude, nous étudions l’interaction bidirectionnelle entre les cellules fibroblastiques réticulaires (FRC) dont le réseau est augmenté dans le FL et les lymphocytes Tfh par analyse des profils d’expression génique, et co-culture in vitro des lymphocytes Tfh primaires avec des cellules fibroblastiques humaines de type FRC-like. Nous démontrons que les c
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Campbell, Scott Bryan. "The role of co-receptor ligation in the differentiation of cytokine-producing T lymphocytes /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17653.pdf.

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Okada(Hashimoto), Mutsumi. "The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4[+] T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans." Kyoto University, 2009. http://hdl.handle.net/2433/126461.

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Perez-Cruz, Isabel. "Analysis of the frequencies of cytokine producing lymphocytes at different developmental stages." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251799.

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Ngamjariyawat, Anongnad, Kyril Turpaev, Svitlana Vasylovska, Elena N. Kozlova, and Nils Welsh. "Co-Culture of Neural Crest Stem Cells (NCSC) and Insulin Producing Beta-TC6 Cells Results in Cadherin Junctions and Protection against Cytokine-Induced Beta-Cell Death." Uppsala universitet, Neuroanatomi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198839.

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PURPOSE: Transplantation of pancreatic islets to Type 1 diabetes patients is hampered by inflammatory reactions at the transplantation site leading to dysfunction and death of insulin producing beta-cells. Recently we have shown that co-transplantation of neural crest stem cells (NCSCs) together with the islet cells improves transplantation outcome. The aim of the present investigation was to describe in vitro interactions between NCSCs and insulin producing beta-TC6 cells that may mediate protection against cytokine-induced beta-cell death. PROCEDURES: Beta-TC6 and NCSC cells were cultured ei
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Hamilton, Michael John. "The development and use of cytokine producing microcapsules for anti-angiogenic therapy in mouse melanoma /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18949.pdf.

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Ness, Kristin Jennifer. "Cytokine requirements for the differentiation and expansion of Il-17a- and Il-22-producing human Vγ2vδ2 T cells". Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2751.

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Human γδ T cells expressing the Vγ2Vδ2 T cell antigen receptor play important roles in immune responses to microbial pathogens by monitoring prenyl pyrophosphate isoprenoid metabolites. Most adult Vγ2Vδ2 cells are memory cytotoxic cells that produce interferon-γ (IFN-γ). Recently, murine γδ T cells were found to be major sources of interleukin (IL)-17A in anti-microbial and autoimmune responses. To determine if primate γδ T cells play similar roles, we characterized IL-17A and IL-22 production by Vγ2Vδ2 T cells. IL-17A-producing memory Vγ2Vδ2 T cells exist at low but significant frequencies in
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Fukui, Tetsuya. "IL-7 induces proliferation, variable cytokine-producing ability and IL-2 responsiveness in naive CD4[+]T cells from human cord blood." Kyoto University, 1998. http://hdl.handle.net/2433/156990.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第7220号<br>医博第1971号<br>新制||医||684(附属図書館)<br>UT51-98-G149<br>京都大学大学院医学研究科内科系専攻<br>(主査)教授 淀井 淳司, 教授 湊 長博, 教授 古庄 巻史<br>学位規則第4条第1項該当
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Yen-Cheng, Chen, and 陳彥丞. "Immunohistochemical study on the cytokine-producing cells in NZB/W F1 mice." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/02864019313977879899.

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碩士<br>國立成功大學<br>微生物暨免疫學研究所<br>87<br>Systemic lupus erythematosus (SLE) is a multisystem disease characterized by disturbances in the immune system associated with the production of autoantibodies to self-antigens. NZB/W F1 mice, which spontaneously develop a lupus-like syndrome characterized by an increased level of autoantibodies in old mice, is a mode for SLE. Dehydroepiandrosterone (DHEA), an abundant adrenal steroid with limited intrinsic androgenic activity, was shown to ameliorate nephritis in NZB/W F1 mice. Cytokines might play an important roles in the development of SLE. IL-10 and IL-
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Books on the topic "Cytokines producing cells"

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Dörner, Thomas, and Peter E. Lipsky. Cellular side of acquired immunity (B cells). Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0050.

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B cells have gained interest in rheumatoid arthritis (RA) beyond being the precursors of antibody-producing plasma cells since they are also a broader component of the adaptive immune system. They are capable of functioning as antigen-presenting cells for T-cell activation and can produce an array of cytokines. Disturbances of peripheral B-cell homeostasis together with the formation of ectopic lymphoid neogenesis within the inflamed synovium appears to be a characteristic of patients with RA. Enhanced generation of memory B cells and autoreactive plasma cells producing IgM-RF and ACPA-IgG ant
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Kirkham, Bruce. Immunology and cytokine pathways. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0007.

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Psoriatic arthritis immunopathology has become the subject of intense study. These findings show differences to other forms of inflammatory arthritis in key pathways. Increased knowledge of innate immunity and the important role of IL-17/23 biology in both psoriasis and psoriatic arthritis, have led to new theories of immunopathogenesis in both conditions. Direct environmental stimuli could trigger innate immune cells resident in skin, which may then initiate a chronic adaptive immune response. The joint has fewer resident innate immune cells, but new studies show cells producing IL-17 may pla
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Breban, Maxime, and Hill Gaston. Immune mechanisms: adaptive immunity. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198734444.003.0008.

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The role of adaptive immunity (i.e. the involvement of B and T lymphocytes) in the pathogenesis of axial spondyloarthritis has been investigated in both human disease and relevant animal models. Studies of B cell responses have not generally implicated an autoantibody in the disease, but there are abnormalities of antibody responses, particularly increased titres of antibodies to various gut bacteria. T cells are critical to the disease in animal models other than those where overexpression of a cytokine is engineered, suggesting that they are the drivers of the inflammatory response. There is
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Book chapters on the topic "Cytokines producing cells"

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Lindén, Anders. "Involvement of Interleukin-17 Cytokines in Human Asthma." In IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Springer Basel, 2012. http://dx.doi.org/10.1007/978-3-0348-0522-3_19.

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Végran, Frédérique, Hélène Berger, and Lionel Apetoh. "Role of IL-17 and IL-17 Family Cytokines on Tumor Development." In IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Springer Basel, 2012. http://dx.doi.org/10.1007/978-3-0348-0522-3_16.

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Schnyder, Bruno, and Silvia Schnyder-Candrian. "Dual Role of Th17 Cytokines, IL-17A,F, and IL-22 in Allergic Asthma." In IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Springer Basel, 2012. http://dx.doi.org/10.1007/978-3-0348-0522-3_10.

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Andersson, Ulf, Mark J. Litton, Tom E. Fehniger, Ann-Kristin Ulfgren, and Jan Andersson. "Detection and Quantification of Cytokine-Producing Cells by Immunostaining." In Techniques in Quantification and Localization of Gene Expression. Birkhäuser Boston, 2000. http://dx.doi.org/10.1007/978-1-4612-1342-0_5.

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Claassen, Eric, Alfons van den Eertwegh, Marjan van Meurs, and Wim Boersma. "In Vivo Localisation Patterns and Cell-Cell Interactions of Cytokine Producing T-Cells and Specific Antibody Forming B-Cells." In In Vivo Immunology. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2492-2_37.

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Lund, Frances E., Beth A. Garvy, Troy D. Randall, and David P. Harris. "Regulatory Roles for Cytokine- Producing B Cells in Infection and Autoimmune Disease." In Current Directions in Autoimmunity. KARGER, 2004. http://dx.doi.org/10.1159/000082086.

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Ueno, Keigo, Makoto Urai, Shogo Takatsuka, Masahiro Abe, Yoshitsugu Miyazaki, and Yuki Kinjo. "Immunization with Antigen-Pulsed Dendritic Cells Against Highly Virulent Cryptococcus gattii Infection: Analysis of Cytokine-Producing T Cells." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7104-6_22.

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Dörner, Thomas, and Peter E. Lipsky. "Cellular side of acquired immunity (B cells)." In Oxford Textbook of Rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0050_update_001.

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B cells have gained interest in rheumatoid arthritis (RA) beyond being the precursors of antibody-producing plasma cells since they are also a broader component of the adaptive immune system. They are capable of functioning as antigen-presenting cells for T-cell activation and can produce an array of cytokines. Disturbances of peripheral B-cell homeostasis together with the formation of ectopic lymphoid neogenesis within the inflamed synovium appears to be a characteristic of patients with RA. Enhanced generation of memory B cells and autoreactive plasma cells producing IgM-RF and ACPA-IgG antibodies together with formation of immune complexes contribute to the maintenance of RA, whereas treatment with B-cell-directed anti-CD20 and CLTA4-Ig therapy provides clinical benefit.
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Levitan, Irwin B., and Leonard K. Kaczmarek. "Neuronal Growth and Trophic Factors." In The Neuron. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199773893.003.0015.

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Neural development requires the participation of growth factors that regulate neuronal determination, proliferation, migration, and differentiation. Molecular genetic approaches using Drosophila, as well as other creatures whose genetics is well understood, have provided insights into the mechanisms of action of some of these developmental factors. Other factors are soluble and are secreted by nearby cells or other neurons. These include neurotrophins such as NGF and BDNF, cytokines such as CNTF, as well as GDNF and steroid hormones. Current research aims to identify key growth factors required for producing different types of neurons, and different patterns of transcription factor activated by different combinations of these factors. This knowledge may eventually allow medical therapies to convert a stem cell into a sympathetic neuron, a motor neuron, or any one of the thousands of other types of neurons that make up a mature nervous system.
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Yoshikawa, Takahisa, Yuki Sato, and Motoko Yanagita. "Heterogeneity of Fibroblasts in Healthy and Diseased Kidneys." In Fibroblasts - Advances in Cancer, Autoimmunity and Inflammation [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99492.

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Chronic kidney disease (CKD) is a worldwide health problem affecting 9.1% of the world’s population. The treatments to prevent the progression of CKD remain limited, however. Resident fibroblasts in the kidneys play crucial roles in the pathological conditions commonly recognized in CKD, such as renal fibrosis, renal anemia, and peritubular capillary loss. Fibroblasts in the kidney provide structural backbone by producing extracellular matrix proteins and produce erythropoietin for normal hematopoiesis under physiological conditions. In the diseased condition, however, fibroblasts differentiate into myofibroblasts that produce excessive extracellular matrix proteins at the cost of the inherent erythropoietin-producing abilities, resulting in renal fibrosis and renal anemia. Pericytes, which are mesenchymal cells that enwrap peritubular capillaries and highly overlap with resident fibroblasts, detach from peritubular capillary walls in response to kidney injury, resulting in peritubular capillary loss and tissue hypoxia. Several reports have demonstrated the beneficial roles of fibroblasts in the regeneration of renal tubules Renal fibroblasts also have the potential to differentiate into a proinflammatory state, producing various cytokines and chemokines and prolonging inflammation by forming tertiary lymphoid tissues, functional lymphoid aggregates, in some pathological conditions. In this article, we describe the heterogenous functions of renal fibroblasts under healthy and diseased conditions.
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Conference papers on the topic "Cytokines producing cells"

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Watanabe, Mototsugu, Shingo Eikawa, Takenori Uehara, et al. "Abstract 4865: Metformin improves multiple cytokine producing ability of exhausted peripheral CD8+ T cells of cancer patients." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4865.

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