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Journal articles on the topic 'Cytokines producing cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Kannanganat, Sunil, Chris Ibegbu, Lakshmi Chennareddi, Harriet L. Robinson, and Rama Rao Amara. "Multiple-Cytokine-Producing Antiviral CD4 T Cells Are Functionally Superior to Single-Cytokine-Producing Cells." Journal of Virology 81, no. 16 (2007): 8468–76. http://dx.doi.org/10.1128/jvi.00228-07.

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ABSTRACT Virus-specific CD4 T cells are endowed with multiple functions, such as cytokine production, CD40 ligand (CD40L) expression (associated with the costimulation of CD8 and B cells), and degranulation (associated with cytotoxic potential). Here, we used antiviral CD4 T cells present in human blood to evaluate the relationship between cytokine production and other functions of CD4 T cells. Antiviral CD4 T cells specific for a virus causing persistent infection, cytomegalovirus (CMV), and two viruses causing nonpersistent infections, influenza virus and the smallpox vaccine virus (vaccinia

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2

Kannanganat, Sunil, Bill G. Kapogiannis, Chris Ibegbu, et al. "Human Immunodeficiency Virus Type 1 Controllers but Not Noncontrollers Maintain CD4 T Cells Coexpressing Three Cytokines." Journal of Virology 81, no. 21 (2007): 12071–76. http://dx.doi.org/10.1128/jvi.01261-07.

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ABSTRACT Here, we evaluate the cytokine coexpression profiles of human immunodeficiency virus (HIV)-specific CD4 T cells for the expression of the cytokines gamma interferon (IFN-γ), interleukin-2, and tumor necrosis factor alpha. In controllers, CD4 T cells producing three or two cytokines (triple producers and double producers, respectively) represented >50% of the total response. In contrast, in noncontrollers ∼75% of responding cells produced only one cytokine (single producers), mostly IFN-γ. Cells producing three cytokines were functionally superior to those producing single cytokines

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Kristensen, Nanna Ny, Andreas Nygaard Madsen, Allan Randrup Thomsen, and Jan Pravsgaard Christensen. "Cytokine production by virus-specific CD8+ T cells varies with activation state and localization, but not with TCR avidity." Journal of General Virology 85, no. 6 (2004): 1703–12. http://dx.doi.org/10.1099/vir.0.79903-0.

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The ability of virus-specific CD8+ T cells to produce cytokines was studied in mice infected with lymphocytic choriomeningitis virus and vesicular stomatitis virus. Intracellular staining was used to visualize cytokine-producing CD8+ and CD4+ T cells. Overall, virus-specific CD8+ T cells produce a similar range of cytokines (IFN-γ, TNF-α, IL-2, GM-CSF, RANTES, MIP-1α and MIP-1β) as CD4+ T cells, but the relative distribution of cytokine-producing subsets is different. Moreover, cytokine-producing CD8+ T cells were found to dominate numerically at all time-points tested. Co-staining for more th

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Wisniewski, Julia A., and Larry Borish. "Novel cytokines and cytokine-producing T cells in allergic disorders." Allergy and Asthma Proceedings 32, no. 2 (2011): 83–94. http://dx.doi.org/10.2500/aap.2011.32.3428.

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5

Jiang, Yanfang, Zhenhua Ma, Guijie Xin, et al. "Th1 and Th2 Immune Response in Chronic Hepatitis B Patients during a Long-Term Treatment with Adefovir Dipivoxil." Mediators of Inflammation 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/143026.

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Adefovir dipivoxil treatment has significantly improved the outcome of chronic hepatitis B virus (HBV) infection. However, it remains largely unknown how immune system responds to the treatment. Chronic HBV patients were treated with adefovir dipivoxil and examined for serum HBV DNA loads, cytokines, and T helper (Th1) and 2 (Th2) cytokine producing T cells during 104 weeks of the treatment. Th1/Th2 cytokines producing T cells were significantly lower in chronic HBV patients as compared to normal individuals. Adefovir dipivoxil treatment led to the increase of Th1/Th2 cytokines producing T cel

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6

Souza, Kleber L. A., Ewa Gurgul-Convey, Matthias Elsner, and Sigurd Lenzen. "Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells." Journal of Endocrinology 197, no. 1 (2008): 139–50. http://dx.doi.org/10.1677/joe-07-0638.

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Pro-inflammatory cytokines cause β-cell dysfunction and death. The aim of this study was to investigate the interactions between different pro- and anti-inflammatory cytokines and their effects on apoptotic β-cell death pathways. Insulin-producing RINm5F cells were exposed to different combinations of cytokines. Gene expression analyses of manganese superoxide dismutase (MnSOD) and inducible nitric oxide synthase (iNOS) were performed by real-time RT-PCR. Cell viability was measured by the MTT assay, NFκB activation using a SEAP reporter gene assay, protein expression by western blotting and c

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7

Webb, LM, and M. Feldmann. "Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells." Blood 86, no. 9 (1995): 3479–86. http://dx.doi.org/10.1182/blood.v86.9.3479.bloodjournal8693479.

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CD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7 costimulatory pathway on development of T helper (Th) subsets. We show that CD28 costimulation is critical for development of the Th2 cytokine-producing cells and that in the absence of CD28 costimulation, cells are not primed to produce Th2 cytokines and consequently “default” to the Th1 subset, independent of the presence of exogenous cytokines. After CD28 costimulation, cells differentiate into a subset that produces Th2 cytokines. However, furt

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Ptackova, Pavlina, Martina Petrackova, Miroslav Hindos, et al. "Intracellular Cytokines Produced by Stimulated CD3+ Cells from Chronic Myeloid Leukemia Patients." Acta Haematologica 137, no. 3 (2017): 148–57. http://dx.doi.org/10.1159/000458703.

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Our work examined the production of intracellular interferon (INF)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-2, and IL-4 by in vitro stimulated CD3+ cells from 38 chronic myeloid leukemia (CML) patients. At the time of diagnosis the percentages of cells producing INF-γ, TNF-α, and IL-2 were strongly suppressed compared to those in healthy control subjects. Hematological remission achieved through treatment with tyrosine-kinase inhibitors was associated with a highly significant increase in the ratio of cells producing all 4 cytokines. The percentages of CD3+ cells producing cytokines

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9

Lucey, D. R., M. Clerici, and G. M. Shearer. "Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases." Clinical Microbiology Reviews 9, no. 4 (1996): 532–62. http://dx.doi.org/10.1128/cmr.9.4.532.

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In the mid-1980s, Mosmann, Coffman, and their colleagues discovered that murine CD4+ helper T-cell clones could be distinguished by the cytokines they synthesized. The isolation of human Th1 and Th2 clones by Romagnani and coworkers in the early 1990s has led to a large number of reports on the effects of Th1 and Th2 on the human immune system. More recently, cells other than CD4+ T cells, including CD8+ T cells, monocytes, NK cells, B cells, eosinophils, mast cells, basophils, and other cells, have been shown to be capable of producing "Th1" and "Th2" cytokines. In this review, we examine the

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Krause, Günter, Floyd Hassenrück, and Michael Hallek. "Relevant Cytokines in the B Cell Lymphoma Micro-Environment." Cancers 12, no. 9 (2020): 2525. http://dx.doi.org/10.3390/cancers12092525.

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Cytokines are soluble protein factors with importance in intercellular communication and, as such, play pivotal roles in the pathogenesis of B cell malignancies. Evidence from in vitro cultures permitted us to choose example cytokines that bind to different biochemical receptor types. Activated malignant B cells or stromal fibroblasts and macrophages prominently secrete the chemokines CCL3 or CXCL12 and CXCL13, respectively. Apart from helper T cells, various cell types of the B cell lymphoma microenvironment are capable of producing the cytokines IL-4, IL-6, IL-10 and TNFα. Owing to its impac

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Zhao, Jimmy L., Chao Ma, Ryan O'Connell, Dinesh S. Rao, James Heath, and David Baltimore. "Single Cell Proteomics Reveals Novel Cytokine-Producing Function of Hematopoietic Stem and Progenitor Cells." Blood 120, no. 21 (2012): 26. http://dx.doi.org/10.1182/blood.v120.21.26.26.

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Abstract Abstract 26 During infection, hematopoietic stem and progenitor cells (HSPCs) are called upon to proliferate and differentiate to produce more innate and adaptive immune cells to combat infection. Traditionally, HSPCs are thought to respond to depletion of downstream hematopoietic cells during infection. More recent evidence suggests that HSPCs may respond directly to infection and pro-inflammatory cytokines. However, little is known about the direct immune response of HSPCs and the molecular signaling regulating this response upon sensing an infection. In this study, we have combined

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Winkler, Stefan, Martin Willheim, Karin Baier, et al. "Reciprocal Regulation of Th1- and Th2-Cytokine-Producing T Cells during Clearance of Parasitemia in Plasmodium falciparum Malaria." Infection and Immunity 66, no. 12 (1998): 6040–44. http://dx.doi.org/10.1128/iai.66.12.6040-6044.1998.

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ABSTRACT Flow cytometry for the intracellular detection of T-cell cytokines was performed for 15 Gabonese patients during acute uncomplicatedPlasmodium falciparum malaria. A striking expansion of CD4+ and CD8+ T cells producing gamma interferon (IFN-γ) was found during drug-induced clearance of parasitemia, paralleled by a decrease of interleukin-2 (IL-2) production. The frequency of IL-4- and IL-13-producing CD4+cells gradually decreased, whereas the frequency of T cells producing IL-2+–IFN-γ+, IL-4−–IL-5+, and IL-4+–IL-5+ cytokines as well as IL-4+–IFN-γ+ and IL-13+–IFN-γ+ cytokines was not

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Wang, Yui-Hsi, Kui Shin Voo, Bo Liu, et al. "A novel subset of CD4+ TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma." Journal of Experimental Medicine 207, no. 11 (2010): 2479–91. http://dx.doi.org/10.1084/jem.20101376.

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The inflammatory cytokine interleukin (IL)-17 is involved in the pathogenesis of allergic diseases. However, the identity and functions of IL-17–producing T cells during the pathogenesis of allergic diseases remain unclear. Here, we report a novel subset of TH2 memory/effector cells that coexpress the transcription factors GATA3 and RORγt and coproduce TH17 and TH2 cytokines. Classical TH2 memory/effector cells had the potential to produce IL-17 after stimulation with proinflammatory cytokines IL-1β, IL-6, and IL-21. The number of IL-17-TH2 cells was significantly increased in blood of patient

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14

Lichtman, Steven, and John Lemasters. "Role of Cytokines and Cytokine-Producing Cells in Reperfusion Injury to the Liver." Seminars in Liver Disease 19, no. 02 (1999): 171–87. http://dx.doi.org/10.1055/s-2007-1007108.

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15

Nicolet, Benoît P., Aurélie Guislain, Floris P. J. van Alphen та ін. "CD29 identifies IFN-γ–producing human CD8+T cells with an increased cytotoxic potential". Proceedings of the National Academy of Sciences 117, № 12 (2020): 6686–96. http://dx.doi.org/10.1073/pnas.1913940117.

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Cytotoxic CD8+T cells can effectively kill target cells by producing cytokines, chemokines, and granzymes. Expression of these effector molecules is however highly divergent, and tools that identify and preselect CD8+T cells with a cytotoxic expression profile are lacking. Human CD8+T cells can be divided into IFN-γ– and IL-2–producing cells. Unbiased transcriptomics and proteomics analysis on cytokine-producing fixed CD8+T cells revealed that IL-2+cells produce helper cytokines, and that IFN-γ+cells produce cytotoxic molecules. IFN-γ+T cells expressed the surface marker CD29 already prior to

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16

Lortz, S., S. Schröter, V. Stückemann, I. Mehmeti, and S. Lenzen. "Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells." Journal of Molecular Endocrinology 52, no. 3 (2014): 301–10. http://dx.doi.org/10.1530/jme-13-0261.

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Free intracellular ferrous iron (Fe2+) is essential for the generation of the extremely toxic hydroxyl radicals, which contribute to β-cell destruction by cytokines. Therefore the expression of the different divalent metal transporter 1 (Dmt1) isoforms and ferritin (Ft) subunits, responsible for iron import and chelation, was analyzed under pro-inflammatory conditions (IL1β alone or together with TNFα+IFNγ). The Dmt1 isoforms (1A/1B and +IRE/−IRE) and the totalDmt1expression in insulin-producing cells (RINm5F and INS-1E), in primary rat islets and, for comparison, in the neuroendocrine PC12 ce

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17

Nakajima, Shihoko, Asako Chiba, Ayako Makiyama, et al. "Association of mucosal-associated invariant T cells with different disease phases of polymyalgia rheumatica." Rheumatology 59, no. 10 (2020): 2939–46. http://dx.doi.org/10.1093/rheumatology/keaa054.

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Abstract Objectives Although T cells are thought to be involved in the pathogenesis of PMR, whether innate-like T cells are involved in the process remains unknown. Methods The serum levels of 27 cytokines/chemokines in patients with PMR were measured by a multiplex immunoassay (Bio-Plex Assay). The cytokine-producing capacity of T and innate-like T cells was assessed by intracellular cytokine staining and flow cytometry. The frequency and activated status of T and innate-like T cells were investigated by flow cytometry and their associations with clinical parameters were assessed. Results The

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Starkie, R. L., J. Rolland, and M. A. Febbraio. "Effect of adrenergic blockade on lymphocyte cytokine production at rest and during exercise." American Journal of Physiology-Cell Physiology 281, no. 4 (2001): C1233—C1240. http://dx.doi.org/10.1152/ajpcell.2001.281.4.c1233.

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To examine the effect of exercise and adrenergic blockade on lymphocyte cytokine production, six men ingested either a placebo (control) or an α- (prazosin hydrochloride) and β-adrenoceptor antagonist (timolol malate) capsule (blockade, or BLK) 2 h before performing 19 ± 1 min of supine bicycle exercise at 78 ± 3% peak pulmonary uptake. Blood was collected before and after exercise, stimulated with phorbol 12-myristate 13-acetate and ionomycin, and surface stained for T (CD3+) and natural killer [NK (CD3−CD56+)] lymphocyte surface antigens. Cells were permeabilized, stained for the intracellul

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19

Del Prete, G. F., and M. Ricci. "Cytokines Involved in the Pathophysiology of IgE Response." International Journal of Immunopathology and Pharmacology 5, no. 2 (1992): 141–48. http://dx.doi.org/10.1177/039463209200500210.

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Recent data in both mouse and human systems have clearly indicated that IL-4 plays an essential role in the induction of IgE response, whereas IFN-γ exerts an opposite effect on this phenomenon. However, IL-4 alone is unable to induce IgE synthesis. A prior membrane contact signal delivered by activated T cells is required by B cells to synthesize IgE in response to IL-4. A cognate interaction between B and T cells producing IL-4 (but not IFN-γ) is optimal for induction of IgE synthesis. However, when such IL-4 producing T cells are activated, they may provide B cells with a membrane signal, t

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Francis, Berline, Arunakumar Gangaplara, Deepali K. Bhat, J. Philip McCoy, and Courtney D. Fitzhugh. "Characterization of Immune Cells Producing Regulatory Cytokines That Mediate Engraftment in Sickle Cell Disease Patients after Haploidentical Peripheral Blood Stem Cell Transplantation." Blood 134, Supplement_1 (2019): 803. http://dx.doi.org/10.1182/blood-2019-130711.

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Sickle cell disease (SCD) is an inherited blood disorder in which red blood cells are sickle-shaped as a result of an amino acid alteration from glutamate to valine at the sixth position of the β-globin chain. Hematopoietic stem cell transplant (HSCT) is a curative option for SCD, with both HLA-matched and haploidentical transplant being viable approaches. Stable mixed chimerism and tolerance induction are sufficient to reverse the sickle phenotype. Graft rejection and graft versus host disease may occur following nonmyeloablative haploidentical peripheral blood stem cell transplantation (PBSC

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Killestein, J., B. F. Den Drijver, W. L. Van der Graaff, B. MJ Uitdehaag, C. H. Polman, and R. AW Van Lier. "Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease." Multiple Sclerosis Journal 7, no. 3 (2001): 145–50. http://dx.doi.org/10.1177/135245850100700302.

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Objective: To evaluate the expression of cytokines in both CD4+ and CD8+ T cells derived from peripheral blood of untreated multiple sclerosis (MS) patients with either relapsing-remitting (RR), secondary progressive (SP) or primary progressive (PP) MS and healthy controls (HC). Background: MS is an immune-mediated disease and cytokines have been hypothesized to contribute significantly to disease progression. Compared to the relapse-onset (RR, SP) form of the disease, PPMS patients have different clinical, immunological and pathological features. Surprisingly, the ability of their circulating

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Lee, Youjin, and Vijay Kuchroo. "Defining the functional states of Th17 cells." F1000Research 4 (May 28, 2015): 132. http://dx.doi.org/10.12688/f1000research.6116.1.

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The molecular mechanisms governing T helper (Th) cell differentiation and function have revealed a complex network of transcriptional and protein regulators. Cytokines not only initiate the differentiation of CD4 Th cells into subsets but also influence the identity, plasticity and effector function of a T cell. Of the subsets, Th17 cells, named for producing interleukin 17 (IL-17) as their signature cytokine, secrete a cohort of other cytokines, including IL-22, IL-21, IL-10, IL-9, IFNγ, and GM-CSF. In recent years, Th17 cells have emerged as key players in host defense against both extracell

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Murray, J. S., J. Madri, J. Tite, S. R. Carding, and K. Bottomly. "MHC control of CD4+ T cell subset activation." Journal of Experimental Medicine 170, no. 6 (1989): 2135–40. http://dx.doi.org/10.1084/jem.170.6.2135.

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The present results demonstrate that CD4+ T cells activated in the primary in vivo response to antigen produce distinct patterns of cytokines depending upon the MHC class II haplotype of the responding mice. I-As mice were found to selectively activate IL-2/IFN-gamma-producing CD4+ T cells, whereas I-Ab mice exhibited selective activation of IL-4-producing CD4+ T cells in response to collagen IV. The effector response phenotype was found to correlate with the cytokine phenotype of CD4+ T cells activated in vivo; IL-2/IFN-gamma-producing cells giving rise to proliferative (cell-mediated) respon

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Alvarez-Rodríguez, L., M. Lopez-Hoyos, C. Mata, et al. "Circulating cytokines in active polymyalgia rheumatica." Annals of the Rheumatic Diseases 69, no. 01 (2009): 263–69. http://dx.doi.org/10.1136/ard.2008.103663.

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Objective:To characterise the circulating cytokine profile and the cellular source of circulating cytokines in polymyalgia rheumatica (PMR).Methods:The study included 34 patients with active untreated PMR and 17 age-matched healthy controls (HC). Circulating cytokines were measured by cytometric bead array and ELISA. Intracellular cytokines were assessed in CD3+ and CD14+ cells by flow cytometry. Cytokines in cell culture supernatants were also determined after polyclonal stimulation of patients’ peripheral blood mononuclear cells.Results:Circulating levels of interleukin-6 (IL6) were signific

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Wurster, Andrea L., Vikki L. Rodgers, Abhay R. Satoskar та ін. "Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells". Journal of Experimental Medicine 196, № 7 (2002): 969–77. http://dx.doi.org/10.1084/jem.20020620.

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The cytokine potential of developing T helper (Th) cells is directly shaped both positively and negatively by the cytokines expressed by the effector Th cell subsets. Here we find that the recently identified cytokine, interleukin (IL)-21, is preferentially expressed by Th2 cells when compared with Th1 cells generated in vitro and in vivo. Exposure of naive Th precursors to IL-21 inhibits interferon (IFN)-γ production from developing Th1 cells. The repression of IFN-γ production is specific in that the expression of other Th1 and Th2 cytokines is unaffected. IL-21 decreases the IL-12 responsiv

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Picker, LJ, MK Singh, Z. Zdraveski, et al. "Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry." Blood 86, no. 4 (1995): 1408–19. http://dx.doi.org/10.1182/blood.v86.4.1408.bloodjournal8641408.

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The array of cytokines produced by T cells in effector sites is a primary means by which these cells mediate host defense. It is well recognized that cloned T cells are heterogeneous with regard to cytokine synthesis and, thus, in their ability to mediate specific immune responses, but the extent to which the patterns of cytokine secretion observed in cloned cells reflect actual populations of memory/effector T cells existing in vivo is largely unknown. Here, we report our findings using a multiparameter flow cytometric assay that allows simultaneous determination of an individual T-cell' abil

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Sosnina, A. V., E. S. Mikhailova, A. I. Autenshlyus, et al. "CYTOKINE-PRODUCING POTENTIAL OF BLOOD CELLS AND SERUM CYTOKINES IN PATIENTS WITH CHRONIC ATROPHIC GASTRITIS." Medical Immunology (Russia) 15, no. 3 (2014): 247. http://dx.doi.org/10.15789/1563-0625-2013-3-247-254.

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Sigfrid, LA, JM Cunningham, N. Beeharry, et al. "Cytokines and nitric oxide inhibit the enzyme activity of catalase but not its protein or mRNA expression in insulin-producing cells." Journal of Molecular Endocrinology 31, no. 3 (2003): 509–18. http://dx.doi.org/10.1677/jme.0.0310509.

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Pancreatic beta-cells have low activities of the antioxidant enzyme catalase. Nitric oxide interacts with the haem group of catalase inhibiting its activity. We have studied the activity of catalase in beta-cells under conditions mimicking prediabetes and in which nitric oxide is generated from cytokine treatment in vitro. We also studied whether there is regulation of catalase enzyme activity by nitric oxide at the protein or gene expression level. RINm5F insulin-producing cells, treated for 24 h with cytokines, showed increased medium nitrite production (17+/-2.2 vs 0.3+/-0.2 pmol/ micro g p

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Ciardelli, L., F. Garofoli, M. Stronati, et al. "Human Colostrum T Lymphocytes and Their Effector Cytokines Actively Aid the Development of the Newborn Immune System." International Journal of Immunopathology and Pharmacology 21, no. 4 (2008): 781–86. http://dx.doi.org/10.1177/039463200802100402.

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Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production. We also considered paired cord blood T-lymphocytes (CBTL) representing the newborn “virgin” immune system. CoTL showed memory phenotype while CBTL expressed mainly naïve phenotype. CoTL included a balanced percentage of helper and cytotoxic subsets. We observed higher percentages of IL-2 (p=0.003) and IL-4 (p=0.027) producing cells by helper rather than by cytotoxic T lymphocytes. The greatest perce

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Triantafilou, Kathy, and Martha Triantafilou. "Coxsackievirus B4-Induced Cytokine Production in Pancreatic Cells Is Mediated through Toll-Like Receptor 4." Journal of Virology 78, no. 20 (2004): 11313–20. http://dx.doi.org/10.1128/jvi.78.20.11313-11320.2004.

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ABSTRACT Coxsackievirus B4 (CBV4), a member of the Picornavirus genus, has long been implicated in the development of insulin-dependent diabetes mellitus (IDDM) caused by virus-induced pancreatic cell damage. The progressive destruction of pancreatic β cells is responsible for the development of IDDM. It has recently been suggested that CBV4 infection can induce the production of proinflammatory cytokines, and these cytokines seem to be involved in the damage to the insulin-producing cells. In this study we investigated whether toll-like receptors (TLRs) are responsible for triggering the proi

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Mikhaylova, E. S., N. A. Varaksin, S. A. Arkhipov, A. V. Golovanova, A. A. Studenikina, and A. I. Autenshlyus. "CYTOKINE-PRODUCING RESOURCE OF IMMUNOCOMPETENT BLOOD CELLS IN BREAST TUMORS AND PRECANCEROUS CHANGES OF MAMMARY GLAND." Medical Immunology (Russia) 20, no. 5 (2018): 681–90. http://dx.doi.org/10.15789/1563-0625-2018-5-681-690.

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At present, only ductal carcinoma in situ is included into the group of precancerous lesions of mammary ducts, according to International Agency for the Study of Cancer. However, based on recent publications, in addition to ductal carcinoma in situ, sclerosing adenosis, intraductal proliferative lesions and radial scar may be also attributed to precancerous changes. A variety of both benign and malignant events in mammary gland, the features of neoplastic growth and age of the patients require new approaches to study of carcinogenic events in mammary gland. As based on the known role of cytoki

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Miyahara, Yoshihiro, Kunle Odunsi, Wenhao Chen, Guangyong Peng, Junko Matsuzaki, and Rong-Fu Wang. "Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer." Proceedings of the National Academy of Sciences 105, no. 40 (2008): 15505–10. http://dx.doi.org/10.1073/pnas.0710686105.

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Despite the important role of Th17 cells in the pathogenesis of many autoimmune diseases, their prevalence and the mechanisms by which they are generated and regulated in cancer remain unclear. Here, we report the presence of a high percentage of CD4+ Th17 cells at sites of ovarian cancer, compared with a low percentage of Th17 cells in peripheral blood mononuclear cells from healthy donors and cancer patients. Analysis of cytokine production profiles revealed that ovarian tumor cells, tumor-derived fibroblasts, and antigen-presenting cells (APCs) secreted several key cytokines including IL-1β

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Xu, H., N. A. DiIulio, and R. L. Fairchild. "T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells." Journal of Experimental Medicine 183, no. 3 (1996): 1001–12. http://dx.doi.org/10.1084/jem.183.3.1001.

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Contact hypersensitivity (CHS) is a T cell-mediated response to hapten sensitization of the epidermis. The roles of CD4+ and CD8+ T cells in CHS have remained unclear, however, as studies to define either subset as the T cells mediating CHS have provided conflicting results. The goal of this study was to correlate the in vivo function of CD4+ and CD8+ T cells in CHS with the cytokines produced by each T cell population. Antibody-mediated depletion of CD4+ T cells before sensitization of BALB/c mice with 2,4-dinitrofluorobenzene (DNFB) or oxazolone (Ox) resulted in increased and prolonged CHS r

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Berin, M. Cecilia, Michael B. Dwinell, Lars Eckmann, and Martin F. Kagnoff. "Production of MDC/CCL22 by human intestinal epithelial cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 280, no. 6 (2001): G1217—G1226. http://dx.doi.org/10.1152/ajpgi.2001.280.6.g1217.

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The intestinal mucosa contains a subset of lymphocytes that produce Th2 cytokines, yet the signals responsible for the recruitment of these cells are poorly understood. Macrophage-derived chemokine (MDC/CCL22) is a recently described CC chemokine known to chemoattract the Th2 cytokine producing cells that express the receptor CCR4. The studies herein demonstrate the constitutive production of MDC/CCL22 in vivo by human colon epithelium and by epithelium of human intestinal xenografts. MDC/CCL22 mRNA expression and protein secretion was upregulated in colon epithelial cell lines in response to

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Antony, Jeyaraj, Xiaohua Chen та Paul Szabolcs. "IL-15 Induced Polyclonal CTL Generated From Expanded CBT Cells Against Leukemia Cell Lines Constitutes IFN-γ Producing Cells and TCRγδ Cells". Blood 120, № 21 (2012): 1910. http://dx.doi.org/10.1182/blood.v120.21.1910.1910.

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Abstract Abstract 1910 Background: We have previously demonstrated that ex vivo expanded CBT cells expanded with CD3/CD28 co-stimulatory beads + IL-2 and IL-7 were receptive to subsequent in vitro priming against killed lymphoid and myeloid leukemia cells in the presence of IL-7, IL-12, and IL-15, (Davis et al. Cancer Research 2010;70(13):5249). Hypothesis and Objectives: Here, we wanted to test 1) the minimum prerequisite cytokine requirement, hypothesizing that higher specificity may be obtained if less exogenous cytokine is employed. 2) Determine the mechanism of CTL's kill by employing blo

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Makeeva, Natalia, Jason W. Myers, and Nils Welsh. "Role of MKK3 and p38 MAPK in cytokine-induced death of insulin-producing cells." Biochemical Journal 393, no. 1 (2005): 129–39. http://dx.doi.org/10.1042/bj20050814.

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The aim of the present investigation was to elucidate further the importance of p38 MAPK (mitogen-activated protein kinase) in nitric oxide- and cytokine-induced β-cell death. For this purpose, isolated human islets were treated with d-siRNA (diced small interfering RNA) and then exposed to the nitric oxide donor DETA/NONOate [2,2′-(hydroxynitrosohydrazono)bis-ethanamine]. We observed that cells treated with p38α-specific d-siRNA, but not with d-siRNA targeting GL3 (a firefly luciferase siRNA plasmid) or PKCδ (protein kinase Cδ), were protected against nitric oxide-induced death. This was para

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Esser, Ruth, Wolfgang Glienke, Reinhard Andreesen, et al. "Individual Cell Analysis of the Cytokine Repertoire in Human Immunodeficiency Virus-1–Infected Monocytes/Macrophages by a Combination of Immunocytochemistry and In Situ Hybridization." Blood 91, no. 12 (1998): 4752–60. http://dx.doi.org/10.1182/blood.v91.12.4752.

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Abstract The expression of many cytokines is dysregulated in individuals infected with the human immunodeficiency virus-1 (HIV-1). To determine the effects of HIV-1 infection on cytokine expression in individual cells (at the single cell level), we investigated the intracellular levels of proinflammatory cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, and IL-8) and hematopoietic growth factors (granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor [GM-CSF]) in monocyte-derived macrophages, mock-infected, or infected with HIV-1 by i

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Esser, Ruth, Wolfgang Glienke, Reinhard Andreesen, et al. "Individual Cell Analysis of the Cytokine Repertoire in Human Immunodeficiency Virus-1–Infected Monocytes/Macrophages by a Combination of Immunocytochemistry and In Situ Hybridization." Blood 91, no. 12 (1998): 4752–60. http://dx.doi.org/10.1182/blood.v91.12.4752.412k06_4752_4760.

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The expression of many cytokines is dysregulated in individuals infected with the human immunodeficiency virus-1 (HIV-1). To determine the effects of HIV-1 infection on cytokine expression in individual cells (at the single cell level), we investigated the intracellular levels of proinflammatory cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, and IL-8) and hematopoietic growth factors (granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor [GM-CSF]) in monocyte-derived macrophages, mock-infected, or infected with HIV-1 by immunocyto

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Obrycki, L., L. Gackowska, A. Niemirska, et al. "[PP.04.11] REGULATORY T CELLS AND CELLS PRODUCING CYTOKINES IN CHILDREN WITH PRIMARY HYPERTENSION." Journal of Hypertension 34 (September 2016): e139. http://dx.doi.org/10.1097/01.hjh.0000491711.03619.9f.

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PODDUBNYY, DENIS A., ELISABETH MÄRKER-HERMANN, WIEBKE KALUZA-SCHILLING та ін. "Relation of HLA-B27, Tumor Necrosis Factor-α Promoter Gene Polymorphisms, and T Cell Cytokine Production in Ankylosing Spondylitis — A Comprehensive Genotype-Phenotype Analysis from an Observational Cohort". Journal of Rheumatology 38, № 11 (2011): 2436–41. http://dx.doi.org/10.3899/jrheum.110130.

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Objective.In a pilot study, a distinct T cell cytokine pattern associated with HLA-B27 status and a tumor necrosis factor-α (TNF-α) promoter gene polymorphism was found at –308 (TNF–308). The objective of our study was to assess these associations in a different cohort of patients with ankylosing spondylitis (AS) and to evaluate any effect on clinical measurements.Methods.Peripheral T cell cytokine production of patients with AS (n = 121) from the German Spondyloarthritis Inception Cohort was assessed by flow cytometry and correlated with HLA-B27, TNF–238, and TNF–308, and with clinical measur

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Ghezzi, Laura, Claudia Cantoni, Francesca Cignarella, et al. "T cells producing GM-CSF and IL-13 are enriched in the cerebrospinal fluid of relapsing MS patients." Multiple Sclerosis Journal 26, no. 10 (2019): 1172–86. http://dx.doi.org/10.1177/1352458519852092.

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Background: Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune demyelinating disease. Its pathogenesis involves humoral and cellular immunity, with production of pro- and anti-inflammatory cytokines by T cells. Objective: To analyze the cytokine profile of cerebrospinal fluid (CSF) T cells in patients with relapsing-remitting MS (RRMS) and non-inflammatory controls. Methods: T cell cytokine production was analyzed by flow cytometry in CSF samples collected from 34 untreated RRMS patients and 20 age-matched controls. Immunofluorescence studies were performed in spinal cord MS

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Schlueter, Annette J., Joon Seong Park, Werner W. Wilke, Ji Fan, and Roger D. Gingrich. "Effect of Aging on Host Dendritic Cell (DC) Numbers and Function, and Response to Regulatory DC Treatment in a Murine Allogeneic Transplant Model." Blood 108, no. 11 (2006): 3244. http://dx.doi.org/10.1182/blood.v108.11.3244.3244.

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Abstract Graft versus host disease (GVH) incidence and severity increases with older patient age. Host dendritic cells (DC) are responsible for initiating GVH, presumably as a result of activation at the time of transplant conditioning (as they are short lived after transplantation). Age-related alterations in host DC function have not been studied in a transplant setting. In this study, young (8–14 wk) and older (12–16 mo) mice were treated with the conditioning regimen of lethal irradiation (1100 cGy) and assessed at 6 h later for changes in DC costimulatory molecule expression and cytokine

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Jensen, Janne, Elisabeth D. Galsgaard, Allan E. Karlsen, Ying C. Lee та Jens H. Nielsen. "STAT5 activation by human GH protects insulin-producing cells against interleukin-1β, interferon-γ and tumour necrosis factor-α-induced apoptosis independent of nitric oxide production". Journal of Endocrinology 187, № 1 (2005): 25–36. http://dx.doi.org/10.1677/joe.1.06086.

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The proinflammatory cytokines interleukin-1β (IL-1β), interferon-γ (IFN-γ) and tumour necrosis factor-α (TNF-α) are toxic to pancreatic β-cells and are implicated in the pathogenesis of type 1 diabetes. We have previously found that GH and prolactin (PRL) stimulate both proliferation and insulin production in pancreatic β-cells and rat insulin-producing INS-1 cells. Here we report that human (h) GH can prevent the apoptotic effects of IL-1β, IFN-γ and TNF-α in INS-1 and INS-1E cells. Using adenovirus-mediated gene transfer, we found that the anti-apoptotic effect of hGH is abrogated by express

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Varga, Steven M., and Raymond M. Welsh. "High Frequency of Virus-Specific Interleukin-2-Producing CD4+ T Cells and Th1 Dominance during Lymphocytic Choriomeningitis Virus Infection." Journal of Virology 74, no. 9 (2000): 4429–32. http://dx.doi.org/10.1128/jvi.74.9.4429-4432.2000.

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ABSTRACT Analysis of C57BL/6 mice acutely infected with lymphocytic choriomeningitis virus (LCMV) by using intracellular cytokine staining revealed a high frequency (2 to 10%) of CD4+ T cells secreting the Th1-associated cytokines interleukin-2 (IL-2), gamma interferon (IFN-γ), and tumor necrosis factor alpha, with no concomitant increase in the frequency of CD4+ T cells secreting the Th2-associated cytokines IL-4, IL-5, and IL-10 following stimulation with viral peptides. In LCMV-infected C57BL/6 CD8−/− mice, more than 20% of the CD4+ T cells secreted IFN-γ after viral peptide stimulation, wh

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Melgar-Rodríguez, Samanta, Emilio A. Cafferata, Nicolás I. Díaz, et al. "Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells." Mediators of Inflammation 2021 (September 20, 2021): 1–13. http://dx.doi.org/10.1155/2021/5573937.

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Natural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. Functionally, NKT cells are capable of performing either effector or suppressor immune responses, depending on their production of proinflammatory or anti-inflammatory cytokines, respectively. Effector NKT cells are subdivided into three subsets, termed NKT1, NKT2, and NKT17, based on the cytokines they produce and their similarity to the cytokine profile produced by Th1, Th2, and Th17 lymphocy

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Onder, Lucas, Priyanka Narang, Elke Scandella, et al. "IL-7–producing stromal cells are critical for lymph node remodeling." Blood 120, no. 24 (2012): 4675–83. http://dx.doi.org/10.1182/blood-2012-03-416859.

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AbstractNonhematopoietic stromal cells of secondary lymphoid organs form important scaffold and fluid transport structures, such as lymph node (LN) trabeculae, lymph vessels, and conduits. Furthermore, through the production of chemokines and cytokines, these cells generate a particular microenvironment that determines lymphocyte positioning and supports lymphocyte homeostasis. IL-7 is an important stromal cell-derived cytokine that has been considered to be derived mainly from T-cell zone fibroblastic reticular cells. We show here that lymphatic endothelial cells (LECs) are a prominent source

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Itoh, Yasushi, and Ronald N. Germain. "Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4+ T Cells." Journal of Experimental Medicine 186, no. 5 (1997): 757–66. http://dx.doi.org/10.1084/jem.186.5.757.

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T cell receptor (TCR) recognition of peptide–major histocompatibility complex antigens can elicit a diverse array of effector activities. Here we simultaneously analyze TCR engagement and the production of multiple cytokines by individual cells in a clonal Th1 CD4+ cell population. Low concentrations of TCR ligand elicit only interferon-γ (IFN-γ) production. Increasing ligand recruits more cells into the IFN-γ+ pool, increases IFN-γ produced per cell, and also elicits IL-2, but only from cells already making IFN-γ. Most cells producing only IFN-γ show less TCR downmodulation than cells produci

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Komanduri, Krishna V., Tae Kon Kim, Eric D. Wieder, and Lisa S. St. John. "Cytokine Production Signatures Are Intrinsically Associated with Human T Cell Maturation Stages." Blood 110, no. 11 (2007): 1337. http://dx.doi.org/10.1182/blood.v110.11.1337.1337.

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Abstract Our recent published studies have suggested that impaired immune reconstitution after allogeneic stem cell transplantation is associated with a greater proportion of circulating late memory T cells, defined phenotypically. To characterize the relationship between immunophenotypic markers of T cell maturation and functional attributes of T cells, we optimized an 8-color, 10-parameter cytokine flow cytometry (CFC) approach and studied T cells from healthy donors. T cells were exposed to stimuli that both bypass (PMA:Ionomycin, P:I) and signal through the T cell receptor (Staph enterotox

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Sun, Xiangle, Harlan P. Jones, Lisa M. Hodge та Jerry W. Simecka. "Cytokine and Chemokine Transcription Profile during Mycoplasma pulmonis Infection in Susceptible and Resistant Strains of Mice: Macrophage Inflammatory Protein 1β (CCL4) and Monocyte Chemoattractant Protein 2 (CCL8) and Accumulation of CCR5+ Th Cells". Infection and Immunity 74, № 10 (2006): 5943–54. http://dx.doi.org/10.1128/iai.00082-06.

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ABSTRACT The progression of murine mycoplasma pneumonia is dependent on T cells and other immune cells. The role of cytokines in immunity are complex, and identifying the network of cytokines produced after infection of mice is essential in dissecting the key cytokine cascades involved mycoplasma disease pathogenesis. In the present study, mRNA expression of 143 different cytokines, chemokines, or receptors were evaluated in lung tissues from both susceptible (BALB/c and C3H/HeN) and resistant (C57BL/6) mice after Mycoplasma pulmonis infection. To accomplish this, membrane-based cDNA microarra

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Lee, Bang-Ning, Madeleine Duvic, Chih-Kwang Tang, Carlos Bueso-Ramos, Zeev Estrov, and James M. Reuben. "Dysregulated Synthesis of Intracellular Type 1 and Type 2 Cytokines by T Cells of Patients with Cutaneous T-Cell Lymphoma." Clinical Diagnostic Laboratory Immunology 6, no. 1 (1999): 79–84. http://dx.doi.org/10.1128/cdli.6.1.79-84.1999.

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ABSTRACT Mycosis fungoides (MF) and Sezary syndrome (SS) are the two main clinical entities of cutaneous T-cell lymphoma (CTCL). As the disease progresses from MF to SS, a switch from a type 1 (interleukin [IL]-2 and gamma interferon [IFN-γ]) to a type 2 (IL-4) cytokine production profile occurs. Although roles for type 1 and type 2 cytokines in the pathogenesis of CTCL have been proposed, the cellular origins of these cytokines are unclear. Using flow cytometry to identify individual T-cell subsets, we studied cytokine synthesis by the T cells of 13 patients with SS and 12 with MF and 9 hemat

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