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Journal articles on the topic 'Cytokinis'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Arli, Naura Muthiah, and Zozy Aneloi Noli. "Shoot Induction of Dendrobium lasianthera J.J.Smith with Several Types of Cytokinins through In Vitro Culture." Jurnal Penelitian Pendidikan IPA 10, no. 4 (2024): 2059–64. http://dx.doi.org/10.29303/jppipa.v10i4.5324.

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Dendrobium lasianthera (Orchidaceae) is one of the potential plants as ornamental plants because it has beautiful and long-lasting flowers. Propagation of orchid plants through in vitro culture technique has been widely done to meet market demand. One of the supporting factors in plant propagation through in vitro culture techniques is growth regulators. Cytokinin is one of the growth regulators commonly used in plant propagation, including orchids. The study aims to determine the effect of several cytokinins and find the best type for shoot induction of Dendrobium lasianthera. The method used

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2

Kuznik, B. I., N. S. Linkova, S. I. Tarnovskaya, and V. Kh Khavinson. "Cytokinis and regulatory peptides: Age-related changes, atherosclerosis, and thrombotic diseases." Advances in Gerontology 3, no. 4 (2013): 243–54. http://dx.doi.org/10.1134/s2079057013040048.

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3

Smigocki, Ann C. "1009 PHENOTYPE MODIFICATION AND DISEASE RESISTANCE VIA REGULATED EXPRESSION OF THE CYTOKININ BIOSYNTHESIS GENE." HortScience 29, no. 5 (1994): 574b—574. http://dx.doi.org/10.21273/hortsci.29.5.574b.

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Cytokinins were first recognized as a class of phytohormones for their ability to promote cytokinesis in cultured plant cells and have since been shown to be involved in a wide range of physiological processes. Most recently, the availability of phytohorm one-specifying genes from Agrobacterium tumefaciens has allowed for direct in planta manipulation of cytokinin levels. Overexpression of the isopentenyl transferase (ipt) gene by constitutive promoters led to enhanced ability of plant cells to undergo shoot organogenesis but the high endogenous cytokinin levels almost completely suppressed ro

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4

Berti, E., and R. Caputo. "Cytokines, cytokine receptors and cytokine antibodies." Melanoma Research 6, SUPPLEMENT 1 (1996): S25. http://dx.doi.org/10.1097/00008390-199609001-00064.

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5

Trinchieri, Giorgio. "Cytokines and cytokine receptors." Immunological Reviews 202, no. 1 (2004): 5–7. http://dx.doi.org/10.1111/j.0105-2896.2004.00217.x.

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6

Dayer, J. M. "Cytokines and cytokine antagonists." Fresenius' Journal of Analytical Chemistry 343, no. 1 (1992): 33–34. http://dx.doi.org/10.1007/bf00331973.

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7

van Deventer, S. J. H. "Cytokines and cytokine-based therapies." Current Opinion in Gastroenterology 14, no. 4 (1998): 317–21. http://dx.doi.org/10.1097/00001574-199807000-00008.

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8

Li, Aileen W., and Wendell A. Lim. "Engineering cytokines and cytokine circuits." Science 370, no. 6520 (2020): 1034–35. http://dx.doi.org/10.1126/science.abb5607.

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9

Burger, D., and J. M. Dayer. "Inhibitory cytokines and cytokine inhibitors." Neurology 45, Issue 6, Supplement 6 (1995): S39—S43. http://dx.doi.org/10.1212/wnl.45.6_suppl_6.s39.

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10

Ansel, John, Patricia Perry, Jeffrey Brown, et al. "Cytokine Modulation of Keratinocyte Cytokines." Journal of Investigative Dermatology 94, no. 6 (1990): s101—s107. http://dx.doi.org/10.1111/1523-1747.ep12876053.

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11

Thipphawong, John. "Inhaled cytokines and cytokine antagonists." Advanced Drug Delivery Reviews 58, no. 9-10 (2006): 1089–105. http://dx.doi.org/10.1016/j.addr.2006.07.014.

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12

Pacáková, Věra, Karel Štulı́k, Věra Vlasáková, and Alena Březinová. "Capillary electrophoresis of cytokinins and cytokinin ribosides." Journal of Chromatography A 764, no. 2 (1997): 331–35. http://dx.doi.org/10.1016/s0021-9673(96)00927-2.

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13

Oslovsky, V. E., E. M. Savelieva, M. S. Drenichev, G. A. Romanov, and S. N. Mikhailov. "Comparative analysis of the biosynthesis of isoprenoid and aromatic cytokinins." Доклады Академии наук 488, no. 6 (2019): 673–76. http://dx.doi.org/10.31857/s0869-56524886673-676.

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To compare the biosynthesis pathways of aromatic and isoprenoid cytokinins, a series of nucleoside derivatives of natural cytokinins was synthesized and their cytokinin activity was determined in a test system based on the model plant Arabidopsis thaliana. Cytokinin nucleosides are known to lack the hormonal activity until cleaving the ribose moiety at the position 9. Our experiments have shown that both ribo- and 5-deoxyribo derivatives of N 6-isopentenyladenine were able to turn into active cytokinins in planta exhibiting cytokinin activity. By contrast, 5-deoxy nucleosides of aromatic cytok

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14

Budiyanto, Moch Agus Krisno, Tien Aminah, H. Husamah, Fendy Hardian Permana, and Lud Waluyo. "Sitokinin Organik: Pendampingan Kelompok Tani Sumber Urip-1 Desa Wonosari Kecamatan Poncokusumo Kabupaten Malang." Sasambo: Jurnal Abdimas (Journal of Community Service) 2, no. 3 (2020): 143–52. http://dx.doi.org/10.36312/sasambo.v2i3.309.

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Mitra dalam pengabdian masyarakat ini Kelompok Tani Sumber Urip-1 yang berlokasi di Desa Poncokusumo Kecamatan Wonorejo Kabupaten Malang Provinsi Jawa Timur-mengalami kendala penggunaan sitokinin organik, yaitu pasokan sitokinin organik terkadang tidak lancar dan harganya mahal sedangkan di banyak daerah mitra terdapat potensi biologis yang dapat digunakan sebagai bahan organik sitokinin. Setelah berdiskusi dengan mitra, permasalahan kongkrit dan prioritas yang akan dibenahi, yaitu 1) Mitra belum menguasai cara pembuatan sitokinin organik berbasis potensi lokal dan 2) Mitra belum menguasai car

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15

Budiyanto, Moch Agus Krisno, Tien Aminah, H. Husamah, Fendy Hardian Permana, and Lud Waluyo. "Sitokinin Organik: Pendampingan Kelompok Tani Sumber Urip-1 Desa Wonosari Kecamatan Poncokusumo Kabupaten Malang." Sasambo: Jurnal Abdimas (Journal of Community Service) 2, no. 3 (2020): 143. http://dx.doi.org/10.36312/sasambo.v2i3.309.

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Mitra dalam pengabdian masyarakat ini Kelompok Tani Sumber Urip-1 yang berlokasi di Desa Poncokusumo Kecamatan Wonorejo Kabupaten Malang Provinsi Jawa Timur-mengalami kendala penggunaan sitokinin organik, yaitu pasokan sitokinin organik terkadang tidak lancar dan harganya mahal sedangkan di banyak daerah mitra terdapat potensi biologis yang dapat digunakan sebagai bahan organik sitokinin. Setelah berdiskusi dengan mitra, permasalahan kongkrit dan prioritas yang akan dibenahi, yaitu 1) Mitra belum menguasai cara pembuatan sitokinin organik berbasis potensi lokal dan 2) Mitra belum menguasai car

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16

Oslovsky, Vladimir, Ekaterina Savelieva, Mikhail Drenichev, Georgy Romanov, and Sergey Mikhailov. "Distinct Peculiarities of In Planta Synthesis of Isoprenoid and Aromatic Cytokinins." Biomolecules 10, no. 1 (2020): 86. http://dx.doi.org/10.3390/biom10010086.

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The biosynthesis of aromatic cytokinins in planta, unlike isoprenoid cytokinins, is still unknown. To compare the final steps of biosynthesis pathways of aromatic and isoprenoid cytokinins, we synthesized a series of nucleoside derivatives of natural cytokinins starting from acyl-protected ribofuranosyl-, 2′-deoxyribofuranosyl- and 5′-deoxyribofuranosyladenine derivatives using stereoselective alkylation with further deblocking. Their cytokinin activity was determined in two bioassays based on model plants Arabidopsis thaliana and Amaranthus caudatus. Unlike active cytokinins-bases, cytokinin

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17

Standiford, Theodore. "Anti-inflammatory Cytokines and Cytokine Antagonists." Current Pharmaceutical Design 6, no. 6 (2000): 633–49. http://dx.doi.org/10.2174/1381612003400533.

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18

BARRY, M., and G. McFADDEN. "Virus encoded cytokines and cytokine receptors." Parasitology 115, no. 7 (1997): 89–100. http://dx.doi.org/10.1017/s0031182097001820.

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In order to replicate efficiently within the host, viruses have evolved multiple strategies to evade the host's immune system. In many cases viruses have actually hijacked various components of the host's immune system to ensure their own survival. One such strategy is the expression of virus encoded cytokines and cytokine receptors. Members of the poxvirus and herpesvirus families have been particularly successful with this strategy. The study of virus survival strategies provides important information regarding both virus biology as well as information about the immune system itself.

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19

Reynolds, John F. "Summary and Future Direction: Chemical Regulation in Tissue Culture." HortScience 22, no. 6 (1987): 1206–7. http://dx.doi.org/10.21273/hortsci.22.6.1206.

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Abstract This series of papers has expanded upon Skoog's milestone discovery regarding the roles of cytokinins and auxins in morphogenesis of in vitro systems. One of the effects of adenine-based cytokinins in culture systems is the formation of adventitious shoots or the expression of axillary shoots. This symposium reported that a cytokinin response also can be observed by using phenylurea-based cytokinins. Two phenylurea compounds, thidiazuron and 4PU–CI, were illustrated as having strong cytokinin activity, equivalent to or surpassing the adenine-based compounds. One of the effects of thes

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20

Scherbakov, V. I., G. A. Skosyreva, T. I. Ryabichenko, and O. O. Obukhova. "Cytokines and regulation of glucose and lipid metabolism in the obesity." Obesity and metabolism 19, no. 3 (2022): 317–23. http://dx.doi.org/10.14341/omet12863.

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The article presents data of the influence of cytokines of different directions of glucose and lipid metabolism in obesity. A change of the basic paradigm regarding adipose tissue has contributed to a number of recent discoveries. This concerns such basic concepts as healthy and diseased adipocytes, and, as a consequence, changes of their metabolism under the influence of cytokins. Distinguishing the concept of organokines demonstrates that despite the common features of cytokine regulation, each organ has its own specifics features of cytokine regulation, each organ has its own specific an im

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21

Cai, Rui. "Progress in the application of cytokines in lung cancer treatment." Highlights in Science, Engineering and Technology 74 (December 29, 2023): 378–85. http://dx.doi.org/10.54097/zq3ga069.

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Lung cancer is the most common cancer today and has become the leading cause of cancer death worldwide. Previous common therapy of this disease mainly include surgery, radiation therapy, chemotherapy etc., and the recently most focused solution of immunotherapy, therapy making use of immunity agents such as vaccines, monoclonal antibodies and cytokines. Cytokines, such as gefitinib, the epidermal growth factor receptor inhibitor, and bevacizumab, the VEGF inhibitor, have been widely used in the clinic as targets for the treatment of lung cancer. Another application of cytokines in the treatmen

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22

Olbei, M., D. Modos, D. Cozzetto, N. Powell, and T. Korcsmaros. "P070 Global cytokine—cytokine interaction framework to uncover communication channels between elements of the immune system." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i236. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0200.

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Abstract Background Cytokines are small peptides that signal between a variety of cell types and are one of the fundamental communication elements of the immune system. A variety of cytokine—cytokine interactions have previously been investigated in the literature, describing cytokines activating or inhibiting other cytokines in target cell types, and thus progressing the immune response to infection and illness. Disruption of cytokine communication is often an important goal in drug development as these compounds allow quelling and managing an overactive immune response in chronic diseases, s

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23

Nedvěd, Daniel, Petr Hošek, Petr Klíma, and Klára Hoyerová. "Differential Subcellular Distribution of Cytokinins: How Does Membrane Transport Fit into the Big Picture?" International Journal of Molecular Sciences 22, no. 7 (2021): 3428. http://dx.doi.org/10.3390/ijms22073428.

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Cytokinins are a class of phytohormones, signalling molecules specific to plants. They act as regulators of diverse physiological processes in complex signalling pathways. It is necessary for plants to continuously regulate cytokinin distribution among different organs, tissues, cells, and compartments. Such regulatory mechanisms include cytokinin biosynthesis, metabolic conversions and degradation, as well as cytokinin membrane transport. In our review, we aim to provide a thorough picture of the latter. We begin by summarizing cytokinin structures and physicochemical properties. Then, we rev

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24

Zhao, Jiangzhe, Ningning Yu, Min Ju, et al. "ABC transporter OsABCG18 controls the shootward transport of cytokinins and grain yield in rice." Journal of Experimental Botany 70, no. 21 (2019): 6277–91. http://dx.doi.org/10.1093/jxb/erz382.

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Abstract Cytokinins are one of the most important phytohormones and play essential roles in multiple life processes in planta. Root-derived cytokinins are transported to the shoots via long-distance transport. The mechanisms of long-distance transport of root-derived cytokinins remain to be demonstrated. In this study, we report that OsABCG18, a half-size ATP-binding cassette transporter from rice (Oryza sativa L.), is essential for the long-distance transport of root-derived cytokinins. OsABCG18 encodes a plasma membrane protein and is primarily expressed in the vascular tissues of the root,

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25

Aki, Shiori S., Tatsuya Mikami, Satoshi Naramoto, et al. "Cytokinin Signaling Is Essential for Organ Formation in Marchantia polymorpha." Plant and Cell Physiology 60, no. 8 (2019): 1842–54. http://dx.doi.org/10.1093/pcp/pcz100.

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Abstract Cytokinins are known to regulate various physiological events in plants. Cytokinin signaling is mediated by the phosphorelay system, one of the most ancient mechanisms controlling hormonal pathways in plants. The liverwort Marchantia polymorpha possesses all components necessary for cytokinin signaling; however, whether they respond to cytokinins and how the signaling is fine-tuned remain largely unknown. Here, we report cytokinin function in Marchantia development and organ formation. Our measurement of cytokinin species revealed that cis-zeatin is the most abundant cytokinin in Marc

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26

Drutskaya, M. S., E. O. Gubernatorova, E. A. Gorshkova, et al. "Cytokines, reverse genetics and anti-cytokine therapy." Bulletin of Siberian Medicine 18, no. 1 (2019): 38–48. http://dx.doi.org/10.20538/1682-0363-2019-1-38-48.

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Cytokines comprise the molecular language of communication between the cells, which is needed to maintain the homeostatic functions of the body (including the immune system) and mediate various diseases. Many aspects of inflammation, autoimmune diseases and neoplasia are associated with cytokine signaling through specific receptors. The establishment of new physiological functions of “old” cytokines and understanding the molecular and cellular mechanisms of their involvement in disease pathogenesis, as well as the search for new therapeutic targets and development of innovative approaches to a

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27

Kovanen, Panu E., and Warren J. Leonard. "Cytokine signaling: Inhibitors keep cytokines in check." Current Biology 9, no. 23 (1999): R899—R902. http://dx.doi.org/10.1016/s0960-9822(00)80079-2.

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28

Pashinina, Olga A., Tatyana M. Pashkova, Olga L. Kartashova, and Natalya V. Morozova. "Anticytokine activity of <i>Candida</i> spp. and their ability to produce cytokine-like substances." Russian Journal of Immunology 26, no. 1 (2022): 57–62. http://dx.doi.org/10.46235/1028-7221-1150-aao.

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Bacteria are known both to exhibit anticytokine activity (ACA), i.e., to secrete extracellular compounds which inactivate / neutralize various cytokines, and to produce cytokine-like substances (CPV) released to the culture medium. At the same time, the ability of Candida to secrete such substances has not been previously studied. The purpose of our study was to determine the presence of ACA and the ability to produce CPV in Candida strains isolated from the reproductive tract of apparently healthy pregnant women. The experimental series included 26 clinical strains of Candida spp. isola

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Lin, Jian-Xin, and Warren J. Leonard. "Fine-Tuning Cytokine Signals." Annual Review of Immunology 37, no. 1 (2019): 295–324. http://dx.doi.org/10.1146/annurev-immunol-042718-041447.

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Cytokines are secreted or otherwise released polypeptide factors that exert autocrine and/or paracrine actions, with most cytokines acting in the immune and/or hematopoietic system. They are typically pleiotropic, controlling development, cell growth, survival, and/or differentiation. Correspondingly, cytokines are clinically important, and augmenting or attenuating cytokine signals can have deleterious or therapeutic effects. Besides physiological fine-tuning of cytokine signals, altering the nature or potency of the signal can be important in pathophysiological responses and can also provide

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30

Korobova, Alla, Bulat Kuluev, Torsten Möhlmann, Dmitriy Veselov, and Guzel Kudoyarova. "Limitation of Cytokinin Export to the Shoots by Nucleoside Transporter ENT3 and Its Linkage with Root Elongation in Arabidopsis." Cells 10, no. 2 (2021): 350. http://dx.doi.org/10.3390/cells10020350.

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The trans-membrane carrier AtENT3 is known to transport externally supplied cytokinin ribosides and thus promote uptake by cells. However, its role in distributing either exogenous or endogenous cytokinins within the intact plant has not hitherto been reported. To test this, we used ent3-1 mutant Arabidopsis seedlings in which the gene is not expressed due to a T-DNA insertion, and examined the effect on the concentration and distribution of either endogenous cytokinins or exogenous trans-zeatin riboside applied to the roots. In the mutant, accumulation of endogenous cytokinins in the roots wa

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Murvanidze, Nino, Karel Doležal, Lenka Plačková, and Stefaan P. O. Werbrouck. "Metabolism of Fluorinated Topolin Cytokinins in Micropropagated Phalaenopsis amabilis." Horticulturae 10, no. 7 (2024): 727. http://dx.doi.org/10.3390/horticulturae10070727.

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Fluorinated cytokinins have emerged as promising alternatives to traditional cytokinins in Phalaenopsis plant tissue culture, offering enhanced stability and bioactivity. However, their metabolic fate and impact on endogenous cytokinin profiles remain largely unexplored. This study builds upon previous research to investigate the comparative metabolism of the traditional cytokinin 6-Benzylaminopurine (BA) with the successful alternatives 6-(3-fluorobenzylamino)purine (FmT) and 6-(3-fluorobenzylamino)purine 9-riboside (FmTR). Additionally, this study examines the impact of another crucial facto

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32

Popelková, Hana, Marco W. Fraaije, Ondřej Novák, Jitka Frébortová, Kristin D. Bilyeu, and Ivo Frébort. "Kinetic and chemical analyses of the cytokinin dehydrogenase-catalysed reaction: correlations with the crystal structure." Biochemical Journal 398, no. 1 (2006): 113–24. http://dx.doi.org/10.1042/bj20060280.

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CKX (cytokinin dehydrogenase) is a flavoprotein that cleaves cytokinins to adenine and the corresponding side-chain aldehyde using a quinone-type electron acceptor. In the present study, reactions of maize (Zea mays) CKX with five different substrates (N6-isopentenyladenine, trans-zeatin, kinetin, p-topolin and N-methyl-isopentenyladenine) were studied. By using stopped-flow analysis of the reductive half-reaction, spectral intermediates were observed indicative of the transient formation of a binary enzyme–product complex between the cytokinin imine and the reduced enzyme. The reduction rate

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Frébortová, Jitka, and Ivo Frébort. "Biochemical and Structural Aspects of Cytokinin Biosynthesis and Degradation in Bacteria." Microorganisms 9, no. 6 (2021): 1314. http://dx.doi.org/10.3390/microorganisms9061314.

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It has been known for quite some time that cytokinins, hormones typical of plants, are also produced and metabolized in bacteria. Most bacteria can only form the tRNA-bound cytokinins, but there are examples of plant-associated bacteria, both pathogenic and beneficial, that actively synthesize cytokinins to interact with their host. Similar to plants, bacteria produce diverse cytokinin metabolites, employing corresponding metabolic pathways. The identification of genes encoding the enzymes involved in cytokinin biosynthesis and metabolism facilitated their detailed characterization based on bo

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34

Łabędź, Wojciech, Anna Przybyla, Agnieszka Zimna, Mikołaj Dąbrowski, and Łukasz Kubaszewski. "The Role of Cytokines in the Metastasis of Solid Tumors to the Spine: Systematic Review." International Journal of Molecular Sciences 24, no. 4 (2023): 3785. http://dx.doi.org/10.3390/ijms24043785.

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Although many studies have investigated the role of cytokines in bone metastases, our knowledge of their function in spine metastasis is limited. Therefore, we performed a systematic review to map the available evidence on the involvement of cytokines in spine metastasis in solid tumors. A PubMed search identified 211 articles demonstrating a functional link between cytokines/cytokine receptors and bone metastases, including six articles confirming the role of cytokines/cytokine receptors in spine metastases. A total of 68 cytokines/cytokine receptors were identified to mediate bone metastases

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Olbei, M., J. Thomas, I. Hautefort, et al. "P090 Unraveling the rewiring of cytokine signalling in Inflammatory Bowel Disease using a novel network biology approach." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i189. http://dx.doi.org/10.1093/ecco-jcc/jjab232.219.

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Abstract Background Intercellular communication mediated by cytokines is critical to the development of immune responses, particularly in the context of chronic immune-mediated disorders such as inflammatory bowel disease (IBD). By releasing these small molecular weight peptides, the source cells can influence numerous intracellular processes in the target cells, including the secretion of other cytokines downstream. However, there are no readily available resources and studies modelling cytokine-cytokine interactions that would be important for better understanding the dysregulation of cytoki

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Cui, Ang, Teddy Huang, Shuqiang Li, et al. "Systematic dissection of cytokine responses in vivo at single-cell resolution." Journal of Immunology 206, no. 1_Supplement (2021): 106.13. http://dx.doi.org/10.4049/jimmunol.206.supp.106.13.

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Abstract Cytokines mediate a highly complex intercellular signaling network in health and disease. While many individual cytokines have been studied in-depth, we do not have a systems-level view of cell-type-specific responses to each cytokine and do not yet understand how cytokines orchestrate cell-cell communication networks in a complex immune response. To address these two gaps in cytokine biology, we performed single-cell RNA sequencing to measure gene expression profiles of over 20 mouse lymph node cell populations in response to over 80 cytokines in vivo. We first investigated how disti

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Lin, Sheng-Chieh, Li-Shian Shi, and Yi-Ling Ye. "Advanced Molecular Knowledge of Therapeutic Drugs and Natural Products Focusing on Inflammatory Cytokines in Asthma." Cells 8, no. 7 (2019): 685. http://dx.doi.org/10.3390/cells8070685.

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Asthma is a common respiratory disease worldwide. Cytokines play a crucial role in the immune system and the inflammatory response to asthma. Abnormal cytokine expression may lead to the development of asthma, which may contribute to pathologies of this disease. As cytokines exhibit pleiotropy and redundancy characteristics, we summarized them according to their biologic activity in asthma development. We classified cytokines in three stages as follows: Group 1 cytokines for the epithelial environment stage, Group 2 cytokines for the Th2 polarization stage, and Group 3 cytokines for the tissue

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38

Kaur, Gurleen, and Divya Mishra. "AtABCG14: A Long-Distance Root-to-Shoot Carrier of Cytokinin." International Journal of Plant Biology 13, no. 3 (2022): 352–55. http://dx.doi.org/10.3390/ijpb13030029.

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Root-synthesized cytokinins regulate the growth, development, and stress responses of aboveground tissues and follow the transport route via xylem tissue. Arabidopsis ATP-binding cassette (ABC) transporter G family member 14 (AtABCG14) is involved in the xylem loading of root-synthesized cytokinins. However, the phloem unloading of root-synthesized cytokinin and shoot distribution have remained elusive. The recent study by Zhao et al., (2021) proved that the AtABCG14 protein mediates the phloem unloading of cytokinins through the apoplastic pathway indicating the AtABCG14 is a master regulator

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Hong, Chang-Sook, Brenda Diergaarde, and Theresa L. Whiteside. "Abstract PO-096: Cytokines in the lumen of exosomes are undetectable by immunoassays distorting cytokine profiles in HNC patients and healthy donors." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—096—PO—096. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-096.

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Abstract Background: Exosomes, now called small extracellular vesicles (sEV), play a key role in cell-to-cell signaling. They are produced by all cells, circulate freely and are present in all body fluids. Evidence indicates that biologically active cytokines are present on the surface and/or in the lumen of sEV. The contributions of intra-vesicular cytokines to cytokine levels in plasma of cancer patients are unknown. Methods: sEV were isolated by ultrafiltration/size exclusion chromatography from pre-cleared plasma obtained from 30 patients with head and neck squamous cell carcinoma (HNSCC)

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Tosado-Rodríguez, Eduardo, Loyda B. Mendez, Ana M. Espino, et al. "Inflammatory cytokines and a diverse cervicovaginal microbiota associate with cervical dysplasia in a cohort of Hispanics living in Puerto Rico." PLOS ONE 18, no. 12 (2023): e0284673. http://dx.doi.org/10.1371/journal.pone.0284673.

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Cervical cancer (CC) is women’s fourth most common cancer worldwide. A worrying increase in CC rates in Hispanics suggests that besides Human papillomavirus infections, there may be other cofactors included in the epithelial microenvironment that could play a role in promoting the disease. We hypothesized that the cervical microbiome and the epithelial microenvironment favoring inflammation is conducive to disease progression in a group of Hispanics attending gynecology clinics in Puerto Rico. Few studies have focused on the joint microbiota and cytokine profile response in Hispanics outside t

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Simbirtsev, A. S. "Immunopharmacological aspects of the cytokine system." Bulletin of Siberian Medicine 18, no. 1 (2019): 84–95. http://dx.doi.org/10.20538/1682-0363-2019-1-84-95.

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Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of

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Kim, Yong-Ku, and Michael Maes. "The role of the cytokine network in psychological stress." Acta Neuropsychiatrica 15, no. 3 (2003): 148–55. http://dx.doi.org/10.1034/j.1601-5215.2003.00026.x.

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Although a considerable amount of evidence has shown that psychological stress alters peripheral and brain cytokines, the physiological significance of cytokine alteration in psychological stress remains to be elucidated. The aims of this review are to analyze the influence of acute and chronic psychological stresses on the cytokine network in animals and in humans, and to explore the pathophysiological implication of the cytokine changes in psychological stress. Acute psychological stress may increase proinflammatory cytokines both in animals and in humans, and increase T-helper-1 cell cytoki

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Yuwen, Li, Yang Ciqiu, Shi Yi, et al. "A Pilot Study of Protein Microarray for Simultaneous Analysis of 274 Cytokines Between Abdominal Aortic Aneurysm and Normal Aorta." Angiology 70, no. 9 (2019): 830–37. http://dx.doi.org/10.1177/0003319719844678.

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Cytokines play an important role in the pathogenesis of abdominal aortic aneurysm (AAA). We evaluated the cytokine expression profile of large AAA walls using a 274-cytokine protein array. We hypothesized that AAAs are characterized by an inflammatory, chemotactic cytokine profile. We investigated the cytokine expression profile of 12 patients with AAA and 6 nonaneurysmal controls using an antibody-based protein array. The array generated antibodies against homogenized human aortic tissues to validate the cytokines differentially expressed in AAAs and normal aortas. Data were quantified using

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Li, Yuan, Dan Yang, Bo Sun, et al. "Discovery of crucial cytokines associated with abdominal aortic aneurysm formation by protein array analysis." Experimental Biology and Medicine 244, no. 18 (2019): 1648–57. http://dx.doi.org/10.1177/1535370219885101.

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As a common disease, abdominal aortic aneurysm (AAA) features permanently progressively dilated abdominal aorta. Various cytokines are implicated in AAA pathogenesis. Clarification of involved cytokines combined with functional analysis may provide new insights into AAA pathogenesis. Using a mouse model, this study analyzed the cytokine profiles in AAA. Cytokines were measured in AAA tissues of saline control or angiotensin II-treated ApoE−/− mice using an antibody array of 200 cytokines, cytokine receptors, and related proteins. Statistical analysis revealed that 21 of 200 proteins were diffe

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Buxton, Miatta A., Noemi Meraz-Cruz, Brisa N. Sánchez, et al. "Repeated Measures of Cervicovaginal Cytokines during Healthy Pregnancy: Understanding “Normal” Inflammation to Inform Future Screening." American Journal of Perinatology 37, no. 06 (2019): 613–20. http://dx.doi.org/10.1055/s-0039-1685491.

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Abstract Objective This study aimed to describe characteristics of cervicovaginal cytokines obtained during pregnancy from women who subsequently delivered at term. Study Design We used repeated measures of 20 cervicovaginal cytokines, collected on average on a monthly basis, from the second to the ninth month of gestation among 181 term pregnancies in the Mexico City Pregnancy Research on Inflammation, Nutrition, & City Environment: Systematic Analyses cohort (2009–2014). Cytokines were quantified using multiplex assay. Results Cytokine distributions differed more between than within cyto

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Chesnokova, Vera, and Shlomo Melmed. "Minireview: Neuro-Immuno-Endocrine Modulation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis by gp130 Signaling Molecules." Endocrinology 143, no. 5 (2002): 1571–74. http://dx.doi.org/10.1210/endo.143.5.8861.

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Abstract The neuroendocrine and immune systems communicate bidirectionally. The neuro-immune-endocrine interface is mediated by cytokines acting as auto/paracrine or endocrine factors regulating pituitary development, cell proliferation, hormone secretion, and feedback control of the hypothalamic-pituitary-adrenal (HPA) axis. At birth or during neonatal ontogenesis, cytokines produce permanent alterations of HPA axis function and the stress response. Overexpressing IL-6 or leukemia inhibitory factor leads to significant changes in pituitary development and functions. Pituitary corticotroph POM

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Chen, CM, G. Jin, BR Andersen, and JR Ertl. "Modulation of Plant Gene Expression by Cytokinins." Functional Plant Biology 20, no. 5 (1993): 609. http://dx.doi.org/10.1071/pp9930609.

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Cytokinins play important roles in plant growth and development. They regulate the synthesis or degradation of proteins and nucleic acids. Specific mRNAs and proteins are up- and down-regulated by the hormones. Regulation of plant gene expression by cytokinins is at the levels of transcription and post-transcription. Expression of a single gene can be modulated by the interaction of two hormones since the levels of cytokinin-enhanced nitrate reductase transcript are reduced by abscisic acid. Relatively high-affinity cytokinin-binding proteins have been isolated, but the physiological role of t

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Nikovics, Krisztina, Anne-Laure Favier, Mathilde Rocher, et al. "In Situ Identification of Both IL-4 and IL-10 Cytokine–Receptor Interactions during Tissue Regeneration." Cells 12, no. 11 (2023): 1522. http://dx.doi.org/10.3390/cells12111522.

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Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process. Determining the orchestration of cytokine interactions with their receptors on their cellular targets is essential to fully understanding the process of inflammation and tissue regeneration. To this end, we have investigated the interactions of Interleukin-4 cytokine (IL-4)/Interleukin-4 cytokine receptor (IL-4R) and Interleukin-10 cytokine (IL-10)/Interleukin-10 cytokine receptor (IL-10R) using in si

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Olson, Matthew Richard, and Mark H. Kaplan. "Autocrine and paracrine cytokine feedback augment the production of Th2-associated cytokines." Journal of Immunology 196, no. 1_Supplement (2016): 191.22. http://dx.doi.org/10.4049/jimmunol.196.supp.191.22.

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Abstract The Type 2 cytokines (including cytokines from Th2 and Th9 cells) play a critical role in priming of the humoral response, immunity to parasites, and the induction of allergic disease. It has been proposed that unlike Type 1 cytokines (i.e. IFN-γ), the induction of Type 2 cytokines is cell autonomous and requires no additional signals for optimal cytokine production. Contrary to this notion, we found that the addition of golgi transport inhibitors that block cytokine secretion (i.e. monensin (Mon) and brefeldin A (BFA)) during stimulation significantly impaired the induction of Type 2

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Feliciani, C., A. K. Gupta, and D. N. Saucier. "Keratinocytes and Cytokine/Growth Factors." Critical Reviews in Oral Biology & Medicine 7, no. 4 (1996): 300–318. http://dx.doi.org/10.1177/10454411960070040101.

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Cytokines are polypeptide growth factors produced by most nucleated cells in the body, including epithelial cells, keratinocytes, and Langerhans cells in the skin. Cytokines can be classified into interleukins, tumor necrosis factors, chemokines, colony-stimulating factor, interferons, and growth factors. Like classic hormones, cytokines bind to specific receptors to transmit their messages to target cells. Cytokine receptors can be divided into three cytokine receptor superfamilies: the immunoglobulin superfamily, the hematopoietin family, and the tumor necrosis factor family. Following cytok

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