Relevant bibliographies by topics / Cytoplasmic mRNA binding protein p54

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  1. Journal articles
  2. Dissertations / Theses
  3. Conference papers

Academic literature on the topic 'Cytoplasmic mRNA binding protein p54'

Author: Grafiati
Published: 4 June 2021
Last updated: 13 February 2022

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Journal articles on the topic "Cytoplasmic mRNA binding protein p54"

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Murray, M. T., G. Krohne, and W. W. Franke. "Different forms of soluble cytoplasmic mRNA binding proteins and particles in Xenopus laevis oocytes and embryos." Journal of Cell Biology 112, no. 1 (1991): 1–11. http://dx.doi.org/10.1083/jcb.112.1.1.

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To gain insight into the mechanisms involved in the formation of maternally stored mRNPs during Xenopus laevis development, we searched for soluble cytoplasmic proteins of the oocyte that are able to selectively bind mRNAs, using as substrate radiolabeled mRNA. In vitro mRNP assembly in solution was followed by UV-cross-linking and RNase digestion, resulting in covalent tagging of polypeptides by nucleotide transfer. Five polypeptides of approximately 54, 56 60, 70, and 100 kD (p54, p56, p60, p70, and p100) have been found to selectively bind mRNA and assemble into mRNPs. These polypeptides, w
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Legagneux, V., P. Bouvet, F. Omilli, S. Chevalier, and H. B. Osborne. "Identification of RNA-binding proteins specific to Xenopus Eg maternal mRNAs: association with the portion of Eg2 mRNA that promotes deadenylation in embryos." Development 116, no. 4 (1992): 1193–202. http://dx.doi.org/10.1242/dev.116.4.1193.

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Maternal Xenopus Eg mRNAs have been previously identified as transcripts that are specifically deadenylated after fertilization and degraded after the mid blastula transition. Destabilizing cis sequences were previously localised in the 3′ untranslated region of Eg2 mRNA. In order to characterize possible trans-acting factors which are involved in the post-transcriptional regulation of Eg mRNAs, gel-shift and u.v. cross-linking experiments were performed, which allowed the identification of a p53-p55 RNA-binding protein doublet specific for the 3′ untranslated regions of Eg mRNAs. These p53-p5
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Minshall, Nicola, Michel Kress, Dominique Weil, and Nancy Standart. "Role of p54 RNA Helicase Activity and Its C-terminal Domain in Translational Repression, P-body Localization and Assembly." Molecular Biology of the Cell 20, no. 9 (2009): 2464–72. http://dx.doi.org/10.1091/mbc.e09-01-0035.

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The RNA helicase p54 (DDX6, Dhh1, Me31B, Cgh-1, RCK) is a prototypic component of P-(rocessing) bodies in cells ranging from yeast to human. Previously, we have shown that it is also a component of the large cytoplasmic polyadenylation element-binding protein translation repressor complex in Xenopus oocytes and that when tethered to the 3′ untranslated region, Xp54 represses reporter mRNA translation. Here, we examine the role of the p54 helicase activity in translational repression and in P-body formation. Mutagenesis of conserved p54 helicase motifs activates translation in the tethered func
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Ohsumi, T., T. Ichimura, H. Sugano, S. Omata, T. Isobe, and R. Kuwano. "Ribosome-binding protein p34 is a member of the leucine-rich-repeat-protein superfamily." Biochemical Journal 294, no. 2 (1993): 465–72. http://dx.doi.org/10.1042/bj2940465.

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Protein p34 is a non-glycosylated membrane protein characteristic of rough microsomes and is believed to play a role in the ribosome-membrane association. In the present study we isolated cDNA encoding p34 from a rat liver cDNA library and determined its complete amino acid sequence. p34 mRNA is 3.2 kb long and encodes a polypeptide of 307 amino acids with a molecular mass of about 34.9 kDa. Primary sequence analysis, coupled with biochemical studies on the topology, suggested that p34 is a type II signal-anchor protein; it is composed of a large cytoplasmic domain, a membrane-spanning segment
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Yang, M., Z. Fan, and I. A. Polejaeva. "1 Microinjection of CPE-Binding Protein Polyadenylated mRNA Increases Developmental Competence of Bovine Oocytes In Vitro." Reproduction, Fertility and Development 30, no. 1 (2018): 140. http://dx.doi.org/10.1071/rdv30n1ab1.

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Developmental competence is acquired during oocyte growth and maturation while oocytes undergo both nuclear and cytoplasmic changes. Completion of oocyte maturation and subsequent embryo development relies mostly on maternally synthesised and stored mRNAs at the transcriptionally quiescent phase. The temporal and spatial post-transcriptional and translational regulation of the stored mRNA in mammalian oocyte cytoplasm is essential for developmental competence of oocytes and is often controlled via cytoplasmic polyadenylation. Cytoplasmic polyadenylation element (CPE)-binding protein (CPEB) is
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Galbán, Stefanie, Jennifer L. Martindale, Krystyna Mazan-Mamczarz, et al. "Influence of the RNA-Binding Protein HuR in pVHL-Regulated p53 Expression in Renal Carcinoma Cells." Molecular and Cellular Biology 23, no. 20 (2003): 7083–95. http://dx.doi.org/10.1128/mcb.23.20.7083-7095.2003.

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ABSTRACT A recent analysis of gene expression in renal cell carcinoma cells led to the identification of mRNAs whose translation was dependent on the presence of the von Hippel-Lindau (VHL) tumor suppressor gene product, pVHL. Here, we investigate the finding that pVHL-expressing RCC cells (VHL+) exhibited elevated levels of polysome-associated p53 mRNA and increased p53 protein levels compared with VHL-defective (VHL−) cells. Our findings indicate that p53 translation is specifically heightened in VHL+ cells, given that (i) p53 mRNA abundance in VHL+ and VHL− cells was comparable, (ii) p53 de
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Xiao, Lan, Jaladanki N. Rao, Tongtong Zou, et al. "Polyamines Regulate the Stability of Activating Transcription Factor-2 mRNA through RNA-binding Protein HuR in Intestinal Epithelial Cells." Molecular Biology of the Cell 18, no. 11 (2007): 4579–90. http://dx.doi.org/10.1091/mbc.e07-07-0675.

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Maintenance of intestinal mucosal epithelial integrity requires polyamines that modulate the expression of various genes involved in cell proliferation and apoptosis. Recently, polyamines were shown to regulate the subcellular localization of the RNA-binding protein HuR, which stabilizes its target transcripts such as nucleophosmin and p53 mRNAs. The activating transcription factor-2 (ATF-2) mRNA encodes a member of the ATF/CRE-binding protein family of transcription factors and was computationally predicted to be a target of HuR. Here, we show that polyamines negatively regulate ATF-2 express
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Lafarga, Vanesa, Ana Cuadrado, Isabel Lopez de Silanes, Rocio Bengoechea, Oscar Fernandez-Capetillo, and Angel R. Nebreda. "p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint." Molecular and Cellular Biology 29, no. 16 (2009): 4341–51. http://dx.doi.org/10.1128/mcb.00210-09.

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ABSTRACT Activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in the G2/M cell cycle arrest induced by DNA damage, but little is known about the role of this signaling pathway in the G1/S transition. Upregulation of the cyclin-dependent kinase inhibitor p21Cip1 is thought to make a major contribution to the G1/S cell cycle arrest induced by γ radiation. We show here that inhibition of p38 MAPK impairs p21Cip1 accumulation and, as a result, the ability of cells to arrest in G1 in response to γ radiation. We found that p38 MAPK induces p21Cip1 mRNA stabilization, wit
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Gabler, Stefan, Holger Schütt, Peter Groitl, Hans Wolf, Thomas Shenk, and Thomas Dobner. "E1B 55-Kilodalton-Associated Protein: a Cellular Protein with RNA-Binding Activity Implicated in Nucleocytoplasmic Transport of Adenovirus and Cellular mRNAs." Journal of Virology 72, no. 10 (1998): 7960–71. http://dx.doi.org/10.1128/jvi.72.10.7960-7971.1998.

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ABSTRACT The adenovirus type 5 (Ad5) early 1B 55-kDa protein (E1B-55kDa) is a multifunctional phosphoprotein that regulates viral DNA replication and nucleocytoplasmic RNA transport in lytically infected cells. In addition, E1B-55kDa provides functions required for complete oncogenic transformation of rodent cells in cooperation with the E1A proteins. Using the far-Western technique, we have isolated human genes encoding E1B-55kDa-associated proteins (E1B-APs). The E1B-AP5 gene encodes a novel nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family that is hig
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Ramalingam, Satish, Gopalan Natarajan, Chris Schafer, et al. "Novel intestinal splice variants of RNA-binding protein CUGBP2: isoform-specific effects on mitotic catastrophe." American Journal of Physiology-Gastrointestinal and Liver Physiology 294, no. 4 (2008): G971—G981. http://dx.doi.org/10.1152/ajpgi.00540.2007.

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CUG triplet repeat-binding protein 2 (CUGBP2) is a RNA-binding protein that regulates mRNA translation and modulates apoptosis. Here, we report the identification of two splice variants (termed variants 2 and 3) in cultured human intestinal epithelial cells and in mouse gastrointestinal tract. The variants are generated from alternative upstream promoters resulting in the inclusion of additional NH2-terminal residues. Although variant 2 is the predominant isoform in normal intestine, its expression is reduced, whereas variant 1 is overexpressed following γ-irradiation. All three variants bind
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Dissertations / Theses on the topic "Cytoplasmic mRNA binding protein p54"

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Paspuleti, Sreelatha. "Isolation and Identification of O-linked-β-N-acetylglucosamine Modified Proteins (O-GlcNAc) in the Developing Xenopus laevis Oocyte". Scholar Commons, 2004. https://scholarcommons.usf.edu/etd/809.

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Oocyte development in Xenopus laevis spans six morphologically distinct stages (stage I-VI), and is associated with a decrease in protein O-GlcNAc levels. As a first step in elucidating the role of O-GlcNAc in developing oocytes, initial efforts were focused on isolation and identification of fifteen modified proteins that decrease during oocyte development. Stage I oocytes due to their high amounts of these proteins, were used as starting material for purification. Multiple affinity and specific antibody based purification technique were initially used in an attempt to enrich the O-GlcNAc pro
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Huang, Ching-jung. "The role of HnRNP proteins, PSF and nonO/p54[superscript nrb], in pre-mRNA binding and splicing /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004292.

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Fatscher, Tobias [Verfasser], Niels [Gutachter] Gehring, and Karin [Gutachter] Schnetz. "Inhibition of nonsense-mediated mRNA decay by the cytoplasmic poly(A)-binding protein / Tobias Fatscher ; Gutachter: Niels Gehring, Karin Schnetz." Köln : Universitäts- und Stadtbibliothek Köln, 2016. http://d-nb.info/1121745318/34.

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Dong, Shuyun. "Transcript-Specific Cytoplasmic Degradation of YRA1 Pre-mRNA Mediated by the Yeast EDC3 Protein: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/352.

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mRNA degradation is a fundamental process that controls both the level and the fidelity of gene expression. Using a combination of bioinformatic, genomic, genetic, and molecular biology approaches, we have shown that Edc3p, a yeast mRNA decay factor, controls the stability of the intron-containing YRA1 pre-mRNA. We found that Edc3p-mediated degradation of YRA1 pre-mRNA: 1) is a component of a negative feedback loop involved in the autoregulation of YRA1, 2) takes place in the cytoplasm, 3) is independent of translation, 4) occurs through a deadenylation-independent decapping and 5΄ to 3΄ exonu
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DeLigio, James T., and James Thomas DeLigio. "ALTERNATIVE SPLICING OF CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN 2 IS MODULATED VIA SERINE ARGININE SPLICING FACTOR 3 IN CANCER METASTASIS." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5660.

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Our laboratory delineated a role for alternative pre-mRNA splicing (AS) in triple negative breast cancer (TNBC). We found the translational regulator cytosolic polyadenylation element binding protein 2 (CPEB2) which has two isoforms, CPEB2A and CPEB2B, is alternatively spliced during acquisition of anoikis resistance (AnR) and metastasis. The splicing event which determines the CPEB2 isoform is via inclusion/ exclusion of exon four in the mature mRNA transcript. The loss of CPEB2A with a concomitant increase in CPEB2B is required for TNBC cells to metastasize in vivo. We examined RNAseq profil
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Bouillier, Camille. "L'analyse de l'interactome du facteur de transcription M2-1 du Virus Respiratoire Syncytial révèle une interaction avec PABPC1 (polyA-binding protein cytoplasmic 1)." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLV010/document.

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Bien que le Virus Respiratoire Syncytial, responsable de la bronchiolite du nourrisson, soit aujourd’hui un problème de santé publique majeur, il n’existe encore aucun vaccin ou antiviral curatif contre ce pathogène. Le manque de données sur les étapes clés du cycle viral et sur les interactions virus-cellule freine le développement de nouvelles molécules antivirales.Nous avons étudié l’interactome de deux protéines virales : la polymérase L et le facteur de transcription M2-1. Dans ce but, nous avons mis au point un crible s’appuyant à la fois sur des critères d’interactomique et sur des crit
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Lu, Wen-Hsin, and 呂文心. "The Role of Cytoplasmic Polyadenylation Element Binding Protein 2 in Regulating Neuronal mRNA Translation, Synaptic Plasticity and Memory." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/gqvt6w.

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博士<br>國立陽明大學<br>生化暨分子生物研究所<br>106<br>Activity-dependent synthesis of plasticity-related proteins is necessary to sustain long-lasting synaptic modifications and consolidate memory. Regulated mRNA translation contributes to synaptic plasticity, so we investigated the role of the translational regulator CPEB2 in learning and memory. Forebrain-restricted CPEB2-cKO mice exhibited impaired hippocampus-dependent memory in the contextual fear conditioning and Morris water maze tests. CPEB2-cKO hippocampi showed impaired LTP in the SC-CA1 pathway. Reduced surface but not total expression of AMPARs in
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Conference papers on the topic "Cytoplasmic mRNA binding protein p54"

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Beeler, D., L. Fritze, G. Soff, R. Jackman, and R. Rosenberg. "HUMAN THROMBOMODULIN cDNA:SEQUENCE AND TRANSLATED STRUCTURE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643967.

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A 750 bp bovine Thrombomodulin (TM) cDNA fragment was used as an hybridization probe to screen an oligo-dT primed Lambda gtll. cDNA library prepared from human umbilical vein endothelial cell mRNA. A 2.4 kb positive human clone was isolated which showed an 80% nucleotide sequence homology with bovine TM cDNA. This clone and a 550 bp fragment from its 5' end were used to further screen the oligo-dT primed library as well as randomly primed library prepared from the same mRNA. The cDNA clones obtained allow us to describe the overall structure of human TM and reveal that it is extremely similar
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