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Dissertations / Theses on the topic 'Cytoskeletal proteins'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Liu, Gang. "Cytoskeletal proteins of Dictyostelium." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292634.

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2

Baisden, Joseph M. "AFAP-110 is a cSrc activator." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2766.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains v, 149 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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3

Alwash, Ban Hussein Kadhim. "S100 proteins control cytoskeletal dynamics in cancer." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42867.

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The S100 family of calcium binding proteins exhibits a unique pattern of cell type specific expression. These proteins are found in the cytoplasm and/or nucleus of a variety of cells, and involved in the control of a wide range of cellular processes such as cell cycle progression and differentiation. S100A4 and S100A6 are members of the S100 protein family that interact with several molecular targets including the heavy chain of non-muscle myosin IIA (NM IIA) and annexin II, respectively. NM IIA is a major actin-associated motor protein, which is involved in cell motility and cytokinesis. Asse

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4

Snyder, Heidi Ghent. "Fiber type-specific desmin content in human single muscle fibers /." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1253.pdf.

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5

McCarthy, David James. "Analysis of the novel Lyn-associated cytoskeletal modular protein, LACM." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0180.

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A yeast-two hybrid screen with Lyn identified a novel 130 kDa multidomain protein with a 36% identity to Actin Filament Associated Protein (AFAP) 110 and similar domains, including PH domains, potential sites of tyrosine and serine/threonine phosphorylation, a leucine-zipper domain, a potential actin binding site and multimerization site. AFAP110 has been shown to have a role in modulating actin filament integrity and induce lamellipodia formation, and is known to interact with Src family kinases. The aim of this thesis was to characterize this novel protein named Lyn-Associated Cytoskeletal M

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6

MacDonald, Louisa M. "Characterisation of the benzimidazole-binding site on the cytoskeletal protein tubulin." Thesis, MacDonald, Louisa M. (2003) Characterisation of the benzimidazole-binding site on the cytoskeletal protein tubulin. PhD thesis, Murdoch University, 2003. https://researchrepository.murdoch.edu.au/id/eprint/173/.

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The binding kinetics of several benzimidazole compounds were determined with recombinant tubulin monomers and heterodimers from benzimidazole-sensitive and -insensitive organisms. This study utilised the naturally occurring high efficacy of the benzimdazoles for the parasitic protozoa Giardia duodenalis and Encephalitozoon intestinalis. The benzimidazoles are not active against the protozoan Cryptosporidium parvum or mammalian hosts, including humans. The affinity of several benzimidazole derivatives for monomeric and heterodimeric beta-tubulin was clearly demonstrated, thus supporting previou

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7

MacDonald, Louisa M. "Characterisation of the benzimidazole-binding site on the cytoskeletal protein tubulin." Murdoch University, 2003. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20050107.94048.

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The binding kinetics of several benzimidazole compounds were determined with recombinant tubulin monomers and heterodimers from benzimidazole-sensitive and -insensitive organisms. This study utilised the naturally occurring high efficacy of the benzimdazoles for the parasitic protozoa Giardia duodenalis and Encephalitozoon intestinalis. The benzimidazoles are not active against the protozoan Cryptosporidium parvum or mammalian hosts, including humans. The affinity of several benzimidazole derivatives for monomeric and heterodimeric â-tubulin was clearly demonstrated, thus supporting previous s

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8

Ritchie, Sian. "Identification of cytoskeletal proteins as substrates for Ca'2'+ dependent protein kinase." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240317.

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9

Höng, J. "Investigating the structures of evolutionarily conserved cytoskeletal proteins." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604097.

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The parasitic protist <i>Giardia intestinalis, </i>considered to be one of the most ancient eukaryotic organisms, contains a typical eukaryotic cytoskeleton composed of microtubules (αβ-tubulin), microfilaments (actin) and intermediate filaments. Proteins associated with the microtubules include kinesins and additional members of the tubulin superfamily. δ-Tubulin is a member of the tubulin superfamily. The methylotropic yeast <i>P. pastoris </i>was identified as the most suitable host for recombinant expression of <i>G. intestinalis </i>δ-tubulin. High-resolution crystal structures of <i>G. i

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10

Holmes, Fiona Elizabeth. "A study of cytoskeletal proteins in the neuron." Thesis, University of Kent, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242927.

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11

Hayes, Nandini V. L. "A study on cytoskeletal proteins in the synapse." Thesis, University of Kent, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314471.

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12

Bolton, Sarah J. "Studies on the cytoskeletal proteins vinculin and talin." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/35153.

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The role of vinculin in cell adhesion was investigated by isolating NIH3T3 and Balb/c 3T3 cells containing a plasmid vector expressing a vinculin antisense RNA under the control of the MMTV promoter. Stable cell lines of NIH3T3 cells were cultured with dexamethasone but none showed any reduction in vinculin protein levels. Two Balb/c 3T3 cell lines, when cultured with dexamethasone displayed a marked reduction in vinculin levels and displayed an altered cell shape from a spread to a more spindle-shaped morphology. These phenotypic changes were reversible upon removal of the dexamethasone. The

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13

Park, Jin Gyoon. "Function of Cytoskeletal Proteins in GLUT4 Vesicle Transport in Adipocytes: Dissertation." eScholarship@UMMS, 2003. http://escholarship.umassmed.edu/gsbs_diss/273.

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Insulin stimulates glucose uptake in adipose and muscle cells via translocation of the intracellular vesicles containing GLUT4. It was largely unknown whether and/or how the signaling molecules such as PI 3-kinase and Akt regulate the mechanical movements of the GLUT4-containing vesicles. Hence, this study was performed to test the hypothesis that actin and microtubules function in translocating GLUT4 vesicles. Treatments of insulin as well as endothelin-1 (ET-1), an insulin-mimicking peptide which does not act through PI 3-kinase, induced polymerization of actin without affecting the microtub

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14

Auxier, Benjamin. "Evolutionary history of the septin cytoskeletal proteins in opisthokonts." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63550.

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Septins are cytoskeletal proteins important in morphogenesis, cell division and establishing and maintaining cell polarity. Over the course of more than a billion years as Animals and Fungi originated and diversified, their septin genes duplicated and diverged, giving rise to paralogs that encode modular proteins. The septin monomers assemble into heteropolymeric higher order structures that affect cell form by creating physical barriers to diffusion or serving as scaffolds organizing groups of diverse proteins. Here we take advantage of newly sequenced genomes to track the history of septin g

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15

Gilmore, Andrew Peter. "Molecular studies on the cytoskeletal proteins vinculin and talin." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35231.

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Vinculin and talin are components of adherens type cell/ECM junctions (adhesion plaques) where they are thought to form part of the linkage between the cytoplasmic domain of the beta-subunit of integrins and the actin cytoskeleton. Vinculin has been shown to interact with the adhesion plaque proteins talin, paxillin and beta-actinin, and talin has been shown to interact with vinculin, integrins beta1 and beta3, and actin. This study has examined the domain structure of vinculin and talin with regard to the interaction between them. Saturation binding analysis using purified chicken vinculin an

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16

Whiteman, Ineka T. "Cytoskeletal proteins and early neurodegenerative mechanisms in Alzheimer's disease." Thesis, The University of Sydney, 2011. https://hdl.handle.net/2123/28860.

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Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder that is histopathologically characterized by several hallmark lesions, including extracellular plaques comprised of amyloid beta (AB) peptides, neuropil threads and intra-neuronal neurofibrillary tangles, both of which are comprised of hyperphosphorylated microtubule-associated (MAP) protein tau. Neuropil threads are one of the earliest lesions observed in AD brain and the extent of their presence correlates with cognitive decline and disease progression. In addition, rod-like aggregates of actin and actin depolymerizing fact

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17

Fawell, E. H. "Studies on the microvillus cytoskeleton." Thesis, University of Leeds, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355700.

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18

Che, Alexis Pun Kit. "Studies of band 3 rotational mobility in normal and ovalocytic human red blood cell membranes by transient dichroism." Thesis, University of Essex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241212.

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19

Woodward, Robert. "Molecular and immunological characterization of cytoskeletal proteins in Trypanosoma brucei." Thesis, University of Kent, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292369.

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20

Rindisbacher, Lorenz. "Studies on cytoskeletal and cell surface proteins of African trypanosomes /." [S.l.] : [s.n.], 1991. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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21

Vlahovich, Nicole. "The role of cytoskeletal tropomyosins in skeletal muscle and muscle disease." Thesis, View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/32176.

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Cells contain an elaborate cytoskeleton which plays a major role in a variety of cellular functions including: maintenance of cell shape and dimension, providing mechanical strength, cell motility, cytokinesis during mitosis and meiosis and intracellular transport. The cell cytoskeleton is made up of three types of protein filaments: the microtubules, the intermediate filaments and the actin cytoskeleton. These components interact with each other to allow the cell to function correctly. When functioning incorrectly, disruptions to many cellular pathway have been observed with mutations in vari

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22

Gupta, Sneha. "Understanding Regulation of the Cytoskeleton during Cell Cycle Transitions through Examination of Crosstalk between Homologous Fission Yeast Pathways, Septation Initiation Network and Morphogenesis ORB6 Network: A Dissertation." eScholarship@UMMS, 2013. http://escholarship.umassmed.edu/gsbs_diss/693.

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The fission yeast Schizosaccharomyces pombe has become a powerful model system for studying cytokinesis, a process of cytoplasmic division by which one cell divides into two identical daughter cells. Like mammalian cells, S. pombe divides through the use of an actomyosin contractile ring, which is composed of a set of highly conserved cytoskeletal proteins. Cytokinesis in S. pombe is primarily regulated by the SIN pathway, which is activated in late mitosis and is required for actomyosin contractile ring and septum assembly, and also plays a role in spindle checkpoint inactivation, and telopha

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Vlahovich, Nicole. "The role of cytoskeletal tropomyosins in skeletal muscle and muscle disease." View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/32176.

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Thesis (Ph.D.)--University of Western Sydney, 2007.<br>A thesis presented to the University of Western Sydney, College of Health and Science, School of Natural Sciences, in fulfilment of the requirements for the degree of Doctor of Philosophy. Includes bibliographies.

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24

Roberts-Pilgrim, Anna M. Phillips Charlotte L. "Glomerulosclerosis in the Col1a2-deficient mouse model homotrimer pathogenesis and MMP expression /." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/6155.

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Title from PDF of title page (University of Missouri--Columbia, viewed on Feb. 20, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dissertation advisor: Charlotte L. Phillips. Vita. Includes bibliographical references.

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25

Teoh, Désiree Ann. "The role of cytoskeletal proteins in Giardia lamblia-induced epithelial injury." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0025/MQ48048.pdf.

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26

Hughes, Richard Anthony. "Motor and cytoskeletal proteins and their interactions in the inner ear." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420601.

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27

Willetts, Alison. "The role of cytoskeletal proteins in the mechanism of insulin release." Thesis, Aston University, 1988. http://publications.aston.ac.uk/12565/.

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This thesis is concerned with the role of /3-cell cytoskeletal proteins in the mechanism of insulin release from islets of experimental animals, the Aston obese diabetic hyperglycaemic (ob/ob) mouse and their lean littermates and the cultural insulin secreting /?-cell lines, HIT-TT5 and RINm5F. Investigations were carried out into the glucose induced insulin response of the lean and obese mouse islets and HIT-TI5 cells and the D-glyceraldehyde response of RINm5F cells using a static incubation system. Colchicine was found to inhibit insulin release from both lean and obese mouse islets more si

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28

Cai, Xinming Schaller Michael D. "Cytoskeletal signaling proteins complex regulatory mechanisms and roles in innate immunity /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,2155.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Feb. 26, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department or Cell and Developmental Biology, School of Medicine." Discipline: Cell and Developmental Biology; Department/School: Medicine.

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29

Guljamow, Arthur. "Characterization of two eukaryotic cytoskeletal proteins horizontally transferred to a cyanobacterium." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16481.

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Das Cyanobakterium Microcystis aeruginosa PCC 7806 enthält zwei Proteine unbekannter Funktion, welche eine hohe Sequenzähnlichkeit mit Bausteinen des eukaryotischen Aktinzytoskeletts haben. Eines dieser Proteine ist Aktin selbst, das andere ist das Aktinbindeprotein Profilin. Die vorliegende Arbeit enthält eine detaillierte Charakterisierung beider Proteine sowie Vergleiche mit ihren eukaryotischen Verwandten. So inhibiert, im Gegensatz zu Eukaryoten, cyanobakterielles Aktin nicht das Enzym DNaseI. Es bildet jedoch Polymere, die hier mit Phalloidin visualisiert wurden. Konfokale Mikroskopie o

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30

Rosa, Jack. "Perturbation and Modulation of Microtubule Cytoskeletal Elements in Response to the Potentially Oncogenic Molecules, Survivin and P53, and Cytokinesis: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/280.

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A complex network of protein filaments collectively known as the cytoskeleton carries out several crucial cellular processes. These functions include, but are not limited to, motility, cell shape, mitosis and organelle trafficking. The cytoskeleton is also highly responsive, allowing the cell to alter its shape in response to its immediate needs and environment. One of the major components of the cytoskeleton is the microtubule network. To refer to the array of micro tubules in the cell as a skeleton is a misnomer. Microtubules, by virtue of their structure and nature, are highly dynamic, cont

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31

Sun, Ning. "Molecular interactions of the mammalian intermediate filament protein synemin with cytoskeletal proteins present in adhesion sites." [Ames, Iowa : Iowa State University], 2008.

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32

Fransson, Åsa. "Cell signaling by Rho and Miro GTPases : studies of Rho GTPases in cytoskeletal reorganizations and of Miro GTPases in mitochondrial dynamics /." Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8514.

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33

Fenton, Andrew Karl. "Roles of cytoskeletal proteins in the predatory life cycle of Bdellovibrio bacteriovorus." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11537/.

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Bdellovibrio bacteriovorus are small, predatory bacteria that grow within the periplasmic space of a host bacterium. Bdellovibrio has a biphasic life-cycle switching from a uni-nucleoid, growth-senescent ‘attack-phase’ to a novel, multi-nucleoid filamentous ‘growth-phase’, which elongates and divides, growing saprophytically within the periplasmic space of their prey. Little is known to date about Bdellovibrio developmental processes and cell division within this periplasmic niche. Recent publications have demonstrated that bacterial cytoplasms house highly organised matrices of protein struct

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34

Treharne, Kate. "Studies on the interactions of cytoskeletal proteins with membranes in the brain." Thesis, University of Kent, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330189.

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35

Chiu, Sheng-Wen. "Spatiotemporal dynamics of cytoskeletal and chemosensory proteins in the bacterium Rhodobacter sphaeroides." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:d7d05b1a-07c5-4e26-9650-37bcfae2fade.

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The discovery of the prokaryotic cytoskeleton has revolutionized our thinking about spatial organisation in prokaryotes. However, the roles different bacterial cytoskeletal proteins play in the localisations of diverse biomolecules are controversial. Bacterial chemotaxis depends on signalling through large protein clusters and each cell must inherit a cluster on cytokinesis. In Escherichia coli the membrane chemosensory clusters are polar and new static clusters form at pre-cytokinetic sites, ensuring positioning at new poles after cytokinesis and suggesting a role for the bacterial FtsZ and M

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36

Crowley, Jessica Lynn. "Role of Supervillin, a Membrane Raft Protein, in Cytoskeletal Organization and Invadopodia Function." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/406.

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Crucial to a cell’s ability to migrate is the organization of its plasma membrane and associated proteins in a polarized manner to interact with and respond to its surrounding environment. Cells interact with the extracellular matrix (ECM) through specialized contact sites, including podosomes and invadopodia. Tumor cells use F-actin-rich invadopodia to degrade ECM and invade tissues; related structures, termed podosomes, are sites of dynamic ECM interaction and degradation. We show here that supervillin (SV), a peripheral membrane protein that binds F-actin and myosin II,reorganizes the actin

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37

Xing, Yi. "Structural and biochemical studies on the Wnt/[beta]-catenin signaling pathway and the PI3K/CISK signaling pathway /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5680.

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Kunttas-Tatli, Ezgi. "Role of APC Proteins in Regulating Wnt Signaling and Cytoskeletal Organization in Drosophila." Research Showcase @ CMU, 2014. http://repository.cmu.edu/dissertations/423.

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Development of an embryo is a fascinating biological process that requires effective communication between neighboring cells and coordination of movement across the entire organism. At a cellular level, this is achieved by upstream signaling pathways ultimately regulating gene expression to provide cells with cues to perform certain tasks such as cell division, migration, cell rearrangements or changes in cell shape. All of these diverse tasks ultimately rely on rearrangements of the cytoskeleton. However, it is unclear what the molecular connections are between signaling and cytoskeletal dyna

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39

Priddle, Helen. "The use of gene disruption to study the cytoskeletal proteins talin and vinculin." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/35134.

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Talin and vinculin are cytoskeletal proteins co-localising with the integrin family of adhesion receptors at sites of adhesion to the extracellular matrix. To investigate the role of these proteins in cell adhesion, gene disruption by homologous recombination has been used in an attempt to produce cells deficient in talin or vinculin. A C129 mouse embryonic stem (ES) cell ? library was screened with a 5' mouse talin cDNA and talin genomic clones isolated. A promoterless neo gene was inserted into the genomic DNA within the first two coding exons, forming a talin gene disruption vector. This ve

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40

Nicholson, Leigh. "A molecular study on cytoskeletal proteins in the uterus during pregnancy and cancer." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18820.

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The uterus has the unique ability to undergo morphological and functional changes in different biological contexts. Through the investigation of four cytoskeletal proteins, α-parvin, β-parvin, lasp-1 and palladin, during two separate events specific to the uterus, early pregnancy and endometrial carcinoma, this thesis aimed to contribute to both fields of study, whilst additionally determining comparisons and similarities in the molecular processes and proteins involved. Palladin and lasp-1 were both found to increase during the time of implantation, compared to the time of fertilisation. Lasp

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Ramachandran, Preethi. "Cytoskeletal Regulation and Morphogen Signaling During Synaptic Outgrowth at the Drosophila Larval Neuromuscular Junction : A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/442.

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Synaptic plasticity, in its broadest sense, can be defined as the ability of synapses to be modified structurally and functionally in response to various internal and external factors. Growing evidence has established that at the very core of these modifications are alterations in the cytoskeletal architecture. This discovery has led to the unearthing of a number of signaling pathways that might be involved in cytoskeletal regulation and also in the regulation of other aspects of synapse development and plasticity. In this regard, polarity proteins and secreted morphogens such as the Wnt prote

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Ramusi, Matome Jack. "Computational studies of structural properties of both calciumoxide and calcium suphide." Thesis, University of Limpopo (Turfloop Campus), 2006. http://hdl.handle.net/10386/747.

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Thesis (M.Sc. (Physics)) --University of Limpopo, 2006<br>In this work, we are studying the properties of CaS and CaO structures in both atomistic simulation and Density Functional Theory. Defects formation (vacancies, impurity and interstitial) will be mechanism studied by using atomistic simulation method. In this approach, Mott-Littleton method will be used since it is a good ap- proach of defects studies, and further explanation will be given on how the introduction of defects contribute on the stability of the bulk material. Diffusion of different atoms from one lattice site via interst

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Sutton, Deborah Helen. "Analysis of the function of the cytoskeletal proteins vinculin and talin using gene disruption." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29665.

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Talin, a 270 kDa cytoskeletal protein is thought to be a key player in the formation of focal adhesions. Talin (-/-) embryonic stem (ES) cells expressing no intact talin spread less efficiently on gelatin, laminin and fibronectin compared to wild-type ES cells, exhibited extensive membrane blebbing, showed a decrease in cell polarity, and were unable to form focal adhesions when planted on fibronectin. They also showed reduced adhesion to laminin (but not fibronectin), probably due to reduced expression of 1-integrins. The phenotypic characteristics of the talin (-/-) ES cells could be reveale

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44

Gardiner, Fiona Claire. "Elucidating the biological role of actin cytoskeletal proteins in the budding yeast Saccharomyces cerevisiae." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418345.

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Vater, Ruth. "The fate of myofibrillar and cytoskeletal proteins during degeneration and regeneration of skeletal muscle." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334746.

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Director, Laura Taylor. "A Novel Approach For The Identification of Cytoskeletal and Adhesion A-Kinase Anchoring Proteins." ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/264.

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A-kinase anchoring proteins (AKAPs) are signaling scaffolds which provide spatial and temporal organization of signaling pathways in discrete subcellular compartments. Through tethering the cyclic-AMP dependent protein kinase A (PKA), AKAPs target PKA activity to distinct regions in the cell, bringing PKA in close proximity to its target proteins. This provides a high level of specificity and regulation of PKA and its role in mediating a number of biological processes, one of which is cell migration. Cell migration is a highly dynamic and fundamental process, when misregulated can lead to a nu

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Stubberfield, Lisa Marie. "Interactions of Plasmodium falciparum proteins at the membrane skeleton of infected erythrocytes." Monash University, Dept. of Microbiology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9433.

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Osterloh, Jeannette M. "dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/668.

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Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an active autodestruction program, akin to apoptotic cell death; however, loss-of-function mutations capable of potently blocking axon self-destruction have not been described. Using a forward genetic screen in Drosophila, we identified that loss of the Toll receptor adaptor dSarm (sterile a/Armadillo/Toll-Interleukin receptor homology domain protein) cell-autonomously suppresses Wallerian degeneration for weeks after axot

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Osterloh, Jeannette M. "dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/668.

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Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an active autodestruction program, akin to apoptotic cell death; however, loss-of-function mutations capable of potently blocking axon self-destruction have not been described. Using a forward genetic screen in Drosophila, we identified that loss of the Toll receptor adaptor dSarm (sterile a/Armadillo/Toll-Interleukin receptor homology domain protein) cell-autonomously suppresses Wallerian degeneration for weeks after axot

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Herron, Lissa Rocha. "A study of the behaviour and interactions of the novel FERM protein Willin." Thesis, St Andrews, 2008. http://hdl.handle.net/10023/418.

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