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Journal articles on the topic 'Cytoskeleton model'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Durand-Smet, Pauline, Tamsin A. Spelman, Elliot M. Meyerowitz, and Henrik Jönsson. "Cytoskeletal organization in isolated plant cells under geometry control." Proceedings of the National Academy of Sciences 117, no. 29 (2020): 17399–408. http://dx.doi.org/10.1073/pnas.2003184117.

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The cytoskeleton plays a key role in establishing robust cell shape. In animals, it is well established that cell shape can also influence cytoskeletal organization. Cytoskeletal proteins are well conserved between animal and plant kingdoms; nevertheless, because plant cells exhibit major structural differences to animal cells, the question arises whether the plant cytoskeleton also responds to geometrical cues. Recent numerical simulations predicted that a geometry-based rule is sufficient to explain the microtubule (MT) organization observed in cells. Due to their high flexural rigidity and

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2

Akram, Zain, Ishtiaq Ahmed, Heike Mack, et al. "Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals—Illustrated with Four Actin Cytoskeleton Proteins." Cells 9, no. 3 (2020): 672. http://dx.doi.org/10.3390/cells9030672.

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The budding yeast Saccharomyces cerevisiae has an actin cytoskeleton that comprises a set of protein components analogous to those found in the actin cytoskeletons of higher eukaryotes. Furthermore, the actin cytoskeletons of S. cerevisiae and of higher eukaryotes have some similar physiological roles. The genetic tractability of budding yeast and the availability of a stable haploid cell type facilitates the application of molecular genetic approaches to assign functions to the various actin cytoskeleton components. This has provided information that is in general complementary to that provid

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3

Wang, Jizeng, and Long Li. "Coupled elasticity–diffusion model for the effects of cytoskeleton deformation on cellular uptake of cylindrical nanoparticles." Journal of The Royal Society Interface 12, no. 102 (2015): 20141023. http://dx.doi.org/10.1098/rsif.2014.1023.

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Molecular dynamic simulations and experiments have recently demonstrated how cylindrical nanoparticles (CNPs) with large aspect ratios penetrate animal cells and inevitably deform cytoskeletons. Thus, a coupled elasticity–diffusion model was adopted to elucidate this interesting biological phenomenon by considering the effects of elastic deformations of cytoskeleton and membrane, ligand–receptor binding and receptor diffusion. The mechanism by which the binding energy drives the CNPs with different orientations to enter host cells was explored. This mechanism involved overcoming the resistance

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Ning, Liang, Hani Y. Suleiman, and Jeffrey H. Miner. "Synaptopodin deficiency exacerbates kidney disease in a mouse model of Alport syndrome." American Journal of Physiology-Renal Physiology 321, no. 1 (2021): F12—F25. http://dx.doi.org/10.1152/ajprenal.00035.2021.

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Alport syndrome (AS) is a hereditary disease of the glomerular basement with hematuria and proteinuria. Podocytes eventually exhibit foot process effacement, indicating actin cytoskeletal changes. To investigate how cytoskeletal changes impact podocytes, we generated Alport mice lacking synaptopodin, an actin-binding protein in foot processes. Analysis showed a more rapid disease progression, demonstrating that synaptopodin is protective. This suggests that the actin cytoskeleton is a target for therapy in AS and perhaps other glomerular diseases.

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REDONDO, Pedro C., Ana I. LAJAS, Ginés M. SALIDO, Antonio GONZALEZ, Juan A. ROSADO, and José A. PARIENTE. "Evidence for secretion-like coupling involving pp60src in the activation and maintenance of store-mediated Ca2+ entry in mouse pancreatic acinar cells." Biochemical Journal 370, no. 1 (2003): 255–63. http://dx.doi.org/10.1042/bj20021505.

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Store-mediated Ca2+ entry (SMCE) is one of the main pathways for Ca2+ influx in non-excitable cells. Recent studies favour a secretion-like coupling mechanism to explain SMCE, where Ca2+ entry is mediated by an interaction of the endoplasmic reticulum (ER) with the plasma membrane (PM) and is modulated by the actin cytoskeleton. To explore this possibility further we have now investigated the role of the actin cytoskeleton in the activation and maintenance of SMCE in pancreatic acinar cells, a more specialized secretory cell type which might be an ideal cellular model to investigate further th

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6

Jean, Ronald P., Christopher S. Chen, and Alexander A. Spector. "Finite-Element Analysis of the Adhesion-Cytoskeleton-Nucleus Mechanotransduction Pathway During Endothelial Cell Rounding: Axisymmetric Model." Journal of Biomechanical Engineering 127, no. 4 (2005): 594–600. http://dx.doi.org/10.1115/1.1933997.

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Endothelial cells possess a mechanical network connecting adhesions on the basal surface, the cytoskeleton, and the nucleus. Transmission of force at adhesions via this pathway can deform the nucleus, ultimately resulting in an alteration of gene expression and other cellular changes (mechanotransduction). Previously, we measured cell adhesion area and apparent nuclear stretch during endothelial cell rounding. Here, we reconstruct the stress map of the nucleus from the observed strains using finite-element modeling. To simulate the disruption of adhesions, we prescribe displacement boundary co

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7

Symington, Alison L., Selma Zimmerman, and A. M. Zimmerman. "The influence of hydrostatic pressure on the distribution of histone mRNA in HeLa cells." Biochemistry and Cell Biology 71, no. 3-4 (1993): 150–55. http://dx.doi.org/10.1139/o93-024.

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Hydrostatic pressure and HeLa S3 cells were used (as a model system) to investigate the relationship of the cytoskeleton and histone gene expression. Exposure of HeLa S3 cells to hydrostatic pressure of 1000 – 10 000 psi (6.89 × 103 – 6.89 × 104 kPa) disrupts the cytoskeleton and reduces H1 and core histone mRNA and actin mRNA levels as determined by hybridization to specific DNA probes. Soluble and insoluble cell fractions were isolated from HeLa cells after lysis in Triton X-100 buffered with PIPES and being subjected to low-speed centrifugation. The insoluble fraction was designated the cyt

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8

Clark, J. I., J. M. Clark, L. L. David, and H. Matsushima. "Lens cytoskeleton and transparency: A model." Eye 13, no. 3 (1999): 417–24. http://dx.doi.org/10.1038/eye.1999.116.

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9

Liu, Fei, Dan Wu, Xiaoyong Wu, and Ken Chen. "Analyses of the cell mechanical damage during microinjection." Soft Matter 11, no. 7 (2015): 1434–42. http://dx.doi.org/10.1039/c4sm02773f.

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The structure of the cell mechanical model. The cell model contains the membrane networks, the internal cytoskeleton, ACPs, motors and their functions, including the binding/unbinding and the folding/unfolding of the proteins, the polymerization/depolymerization of cytoskeletal filaments, and the walk of motors.

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10

Dufort, Paul A., and Charles J. Lumsden. "Cellular automaton model of the actin cytoskeleton." Cell Motility and the Cytoskeleton 25, no. 1 (1993): 87–104. http://dx.doi.org/10.1002/cm.970250110.

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11

Xu, Jian-Wei, Bo Cheng, Yu-Yu Feng, Zi-Qing Wang, and Guo-Dong Wang. "Cytoskeleton Dynamics: A Continuum Cooperative Hydrolysis Model." Communications in Theoretical Physics 63, no. 5 (2015): 648–52. http://dx.doi.org/10.1088/0253-6102/63/5/648.

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12

Regalado, Carlos M., Brian D. Sleeman, and Karl Ritz. "Aggregation and collapse of fungal wall vesicles in hyphal tips: a model for the origin of the Spitzenkörper." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 352, no. 1364 (1997): 1963–74. http://dx.doi.org/10.1098/rstb.1997.0182.

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The intracellular origins of polarity and branch initiation in fungi centre upon a localization in the supply of fungal wall constituents to specific regions on the hyphal wall. Polarity is achieved and maintained by accumulating secretory vesicles, prior to incorporation into the wall, in the form of an apical body or Spitzenkörper. However, neither the mechanisms leading to this accumulation nor the initiation of branching, are as yet understood. We propose a mechanism, based on experimental evidence, which considers the mechanical properties of the cytoskeleton in order to explain these phe

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13

Shafrir, Yinon, and Gabor Forgacs. "Mechanotransduction through the cytoskeleton." American Journal of Physiology-Cell Physiology 282, no. 3 (2002): C479—C486. http://dx.doi.org/10.1152/ajpcell.00394.2001.

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We constructed a model cytoskeleton to investigate the proposal that this interconnected filamentous structure can act as a mechano- and signal transducer. The model cytoskeleton is composed of rigid rods representing actin filaments, which are connected with springs representing cross-linker molecules. The entire mesh is placed in viscous cytoplasm. The model eukaryotic cell is submitted to either shock wave-like or periodic mechanical perturbations at its membrane. We calculated the efficiency of this network to transmit energy to the nuclear wall as a function of cross-linker stiffness, cyt

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Heidemann, Steven R., Stefanie Kaech, Robert E. Buxbaum, and Andrew Matus. "Direct Observations of the Mechanical Behaviors of the Cytoskeleton in Living Fibroblasts." Journal of Cell Biology 145, no. 1 (1999): 109–22. http://dx.doi.org/10.1083/jcb.145.1.109.

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Cytoskeletal proteins tagged with green fluorescent protein were used to directly visualize the mechanical role of the cytoskeleton in determining cell shape. Rat embryo (REF 52) fibroblasts were deformed using glass needles either uncoated for purely physical manipulations, or coated with laminin to induce attachment to the cell surface. Cells responded to uncoated probes in accordance with a three-layer model in which a highly elastic nucleus is surrounded by cytoplasmic microtubules that behave as a jelly-like viscoelastic fluid. The third, outermost cortical layer is an elastic shell under

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15

Copos, Calina Anamaria, and Robert D. Guy. "A porous viscoelastic model for the cell cytoskeleton." ANZIAM Journal 59 (August 9, 2018): 472. http://dx.doi.org/10.21914/anziamj.v59i0.12339.

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COPOS, CALINA A., and ROBERT D. GUY. "A POROUS VISCOELASTIC MODEL FOR THE CELL CYTOSKELETON." ANZIAM Journal 59, no. 4 (2018): 472–98. http://dx.doi.org/10.1017/s1446181118000081.

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The immersed boundary method is a widely used mixed Eulerian/Lagrangian framework for simulating the motion of elastic structures immersed in viscous fluids. In this work, we consider a poroelastic immersed boundary method in which a fluid permeates a porous, elastic structure of negligible volume fraction, and extend this method to include stress relaxation of the material. The porous viscoelastic method presented here is validated for a prescribed oscillatory shear and for an expansion driven by the motion at the boundary of a circular material by comparing numerical solutions to an analytic

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17

McGhee, Sean A., and Talal A. Chatila. "DOCK8 Immune Deficiency as a Model for Primary Cytoskeletal Dysfunction." Disease Markers 29, no. 3-4 (2010): 151–56. http://dx.doi.org/10.1155/2010/397291.

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DOCK8 deficiency is a newly described primary immune deficiency resulting in profound susceptibility to cutaneous viral infections, elevated IgE levels, and eosinophilia, but lacking in the skeletal manifestations commonly seen in hyper IgE syndrome, which it otherwise resembles. Although little is known about the DOCK8 protein, it resembles other atypical guanine exchange factors in the DOCK family, and is known to bind to CDC42. This suggests that a likely role for DOCK8 is in modulating signals that trigger cytoskeletal reorganization. As a result, DOCK8 may also be related to other immune

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18

Ghaffari, Hamed, Mohammad Said Saidi, and Bahar Firoozabadi. "Biomechanical analysis of actin cytoskeleton function based on a spring network cell model." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 231, no. 7 (2016): 1308–23. http://dx.doi.org/10.1177/0954406216668546.

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In this study, a new method for the simulation of the time-dependent behavior of actin cytoskeleton during cell shape change is proposed. For this purpose, a three-dimensional model of endothelial cell consisting of cell membrane, nucleus membrane, and main components of cytoskeleton, namely actin filaments, microtubules, and intermediate filaments is utilized. Actin binding proteins, which play a key role in regulating actin cytoskeleton behavior, are also simulated by using a novel technique. The actin cytoskeleton in this model is more dynamic and adoptable during cell deformation in compar

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19

Fostinis, Yannis, Panayotis A. Theodoropoulos, Achille Gravanis, and Christos Stournaras. "Heat shock protein HSP90 and its association with the cytoskeleton: a morphological study." Biochemistry and Cell Biology 70, no. 9 (1992): 779–86. http://dx.doi.org/10.1139/o92-118.

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To investigate the cellular localization of the 90-kilodalton heat shock protein (HSP90) and its interaction with the cytoskeleton, we performed single- and double-staining immunofluorescence microscopy of cytoskeletal proteins and HSP90 in the absence and presence of cytoskeletal inhibitors. As a model, we used a human endometrial adenocarcinoma cell line (Ishikawa cells), which expresses HSP90. We confirmed the recently reported colocalization of HSP90 with microtubules. However, Ishikawa cells treated with 10−5 M of the antimicrotubule agents colchicine or triethyl lead showed residual fila

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20

Barns, Sarah, Emilie Sauret, Suvash Saha, Robert Flower, and Yuan Tong Gu. "Two-Layer Red Blood Cell Membrane Model Using the Discrete Element Method." Applied Mechanics and Materials 846 (July 2016): 270–75. http://dx.doi.org/10.4028/www.scientific.net/amm.846.270.

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The red blood cell (RBC) membrane consists of a lipid bilayer and spectrin-based cytoskeleton, which enclose haemoglobin-rich fluid. Numerical models of RBCs typically integrate the two membrane components into a single layer, preventing investigation of bilayer-cytoskeleton interaction. To address this constraint, a new RBC model which considers the bilayer and cytoskeleton separately is developed using the discrete element method (DEM). This is completed in 2D as a proof-of-concept, with an extension to 3D planned in the future. Resting RBC morphology predicted by the two-layer model is comp

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21

Guma, Fatima C. R., Tanira G. Mello, Claudia S. Mermelstein, et al. "Intermediate filaments modulation in an in vitro model of the hepatic stellate cell activation or conversion into the lipocyte phenotype." Biochemistry and Cell Biology 79, no. 4 (2001): 409–17. http://dx.doi.org/10.1139/o01-027.

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Hepatic stellate cells are intralobular connective tissue cells expressing the myofibroblast or the lipocyte phenotypes. They participate in homeostasis of the liver extracellular matrix, repair, regeneration, and fibrosis under the former phenotype, and control the retinol metabolism, storage, and release under the latter one. They are heterogeneous in terms of their tissue distribution, function, and expression of cytoskeletal proteins. We have studied the expressions of intermediate filaments in the cloned GRX cell line representative of murine hepatic stellate cells, by immunolabeling, rev

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22

Bottazzi, Maria Elena, Monica Buzzai, Xiaoyun Zhu, Chantal Desdouets, Christian Bréchot, and Richard K. Assoian. "Distinct Effects of Mitogens and the Actin Cytoskeleton on CREB and Pocket Protein Phosphorylation Control the Extent and Timing of Cyclin A Promoter Activity." Molecular and Cellular Biology 21, no. 22 (2001): 7607–16. http://dx.doi.org/10.1128/mcb.21.22.7607-7616.2001.

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ABSTRACT Soluble mitogens and adhesion-dependent organization of the actin cytoskeleton are required for cells to enter S phase in fibroblasts. The induction of cyclin A is also required for S-phase entry, and we now report that distinct effects of mitogens and the actin cytoskeleton on the phosphorylation of CREB and pocket proteins regulate the extent and timing of cyclin A promoter activity, respectively. First, we show that CREB phosphorylation and binding to the cyclic AMP response element (CRE) determines the extent, but not the timing, of cyclin A promoter activity. Second, we show that

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23

Liu, G., and P. C. Newell. "Evidence of cyclic GMP may regulate the association of myosin II heavy chain with the cytoskeleton by inhibiting its phosphorylation." Journal of Cell Science 98, no. 4 (1991): 483–90. http://dx.doi.org/10.1242/jcs.98.4.483.

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Previous studies have implicated cyclic GMP in the regulation of myosin II heavy chain (MHC) association with the cytoskeleton in Dictyostelium discoideum. Here we provide evidence that cyclic GMP may regulate MHC association with the cytoskeleton through MHC phosphorylation. Comparative data are presented of MHC phosphorylation in the wild-type strain NC4, the parental strain XP55 and streamer mutants NP368 and NP377. Using an anti-MHC monoclonal antibody to immunoprecipitate MHC from [32P]phosphate-labelled developing cells, we found that cyclic AMP stimulation of the wild-type strain NC4 an

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Myers, Kenneth A., Jerome B. Rattner, Nigel G. Shrive, and David A. Hart. "Hydrostatic pressure sensation in cells: integration into the tensegrity model." Biochemistry and Cell Biology 85, no. 5 (2007): 543–51. http://dx.doi.org/10.1139/o07-108.

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Hydrostatic pressure (HP) is a mechanical stimulus that has received relatively little attention in the field of the cell biology of mechanotransduction. Generalized models, such as the tensegrity model, do not provide a detailed explanation of how HP might be detected. This is significant, because HP is an important mechanical stimulus, directing cell behaviour in a variety of tissues, including cartilage, bone, airways, and the vasculature. HP sensitivity may also be an important factor in certain clinical situations, as well as under unique environmental conditions such as microgravity. Whi

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Hagan, I. M. "The fission yeast microtubule cytoskeleton." Journal of Cell Science 111, no. 12 (1998): 1603–12. http://dx.doi.org/10.1242/jcs.111.12.1603.

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The Schizosaccharomyces pombe genome sequencing project (http://www.sanger.ac.uk/Projects/S_pombe/) is nearly complete, and this is likely to generate interest in fission yeast as a model system beyond its traditional strongholds in the study of the cell cycle and sexual differentiation. In many fields S. pombe will offer a useful complement to the more widely studied Saccharomyces cerevisiae, but in some areas the impact of S. pombe may well rival or exceed that of this budding yeast in terms of relevance to higher systems. Because of the considerable differences from the S. cerevisiae microt

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Oliver-Gonzalez, Rubén, Carlos García-Tovar, Lourdes Juárez-Mosqueda, and Fernando Navarro-Garcia. "Infection of rabbit kidney cells (RK13) by enteropathogenicEscherichia colias a model to study the dynamics of actin cytoskeleton." Canadian Journal of Microbiology 54, no. 9 (2008): 748–57. http://dx.doi.org/10.1139/w08-069.

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Enteropathogenic Escherichia coli (EPEC) colonizes the intestinal mucosa and causes a cell lesion known as attachment and effacement (A/E) lesion. The molecular mechanisms for A/E lesions include injection of Tir, which is a receptor for an adhesin named intimin. The Tir–intimin interaction causes rearrangement of the cytoskeleton forming actin-rich structures called pedestals. Unfortunately, the formation of the A/E lesions and the dynamics of the actin cytoskeleton during this rearrangement induced by EPEC cannot be studied in the natural host. However, there are EPEC strains that infect rab

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27

Ganusova, Elena E., Laura N. Ozolins, Srishti Bhagat, et al. "Modulation of Prion Formation, Aggregation, and Toxicity by the Actin Cytoskeleton in Yeast." Molecular and Cellular Biology 26, no. 2 (2006): 617–29. http://dx.doi.org/10.1128/mcb.26.2.617-629.2006.

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ABSTRACT Self-perpetuating protein aggregates transmit prion diseases in mammals and heritable traits in yeast. De novo prion formation can be induced by transient overproduction of the corresponding prion-forming protein or its prion domain. Here, we demonstrate that the yeast prion protein Sup35 interacts with various proteins of the actin cortical cytoskeleton that are involved in endocytosis. Sup35-derived aggregates, generated in the process of prion induction, are associated with the components of the endocytic/vacuolar pathway. Mutational alterations of the cortical actin cytoskeleton d

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28

Tan, Minghui, Caihui Cha, Yongheng Ye, et al. "CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation." Neural Plasticity 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/947423.

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Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and axonal elongation. However, whether and how CRMPs associate with microtubules and actin coordinated cytoskeletal dynamics remain unknown. In this study, we demonstrated that CRMP2 and CRMP4 interacted with tubulin and actinin vitroand colocalized with the cytoskeleton in the transition-zone in developing growth cones. CRMP2 and CRMP4 also interact

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Thuillier, Raphael, and Thierry Hauet. "Impact of Hypothermia and Oxygen Deprivation on the Cytoskeleton in Organ Preservation Models." BioMed Research International 2018 (July 16, 2018): 1–10. http://dx.doi.org/10.1155/2018/8926724.

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Ischemia reperfusion (IR) lesions are an unavoidable consequence of organ transplantation. Researching new therapeutics against these lesions requires the definition of early mechanisms. The cytoskeleton is composed of 3 types of filaments: microfilaments, intermediate filaments, and microtubules. We aimed to characterize the influence of preservation on their phenotype. In an in vitro model using primary human endothelial cells reproducing the conditions of organ preservation, two aspects were explored: (a) the impact of IR and cold ischemia time on each filament type, evaluating the roles of

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Cañadas, Patrick, Bernard Maurin, Haimad Baudriller, Philippe Montcourrier, and Nadir Bettache. "NUMERICAL MODEL OF THE CYTOSKELETON STRUCTURATION DURING CELL SPREADING." Journal of Biomechanics 41 (July 2008): S20. http://dx.doi.org/10.1016/s0021-9290(08)70020-4.

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Hart, T. N., and L. E. H. Trainor. "The two-component model for the cytoskeleton in development." Physica D: Nonlinear Phenomena 44, no. 3 (1990): 269–84. http://dx.doi.org/10.1016/0167-2789(90)90149-j.

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Mao, Bai-Ping, Linxi Li, Ming Yan, Renshan Ge, Qingquan Lian, and C. Yan Cheng. "Regulation of BTB Dynamics in Spermatogenesis—Insights From the Adjudin Model." Toxicological Sciences 172, no. 1 (2019): 75–88. http://dx.doi.org/10.1093/toxsci/kfz180.

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Abstract During spermatogenesis, cell organelles, and germ cells, most notably haploid spermatids, are transported across the seminiferous epithelium so that fully developed spermatids line-up at the edge of the tubule lumen to undergo spermiation at stage VIII of the cycle. Studies have suggested that the microtubule (MT)-based cytoskeleton is necessary to support these cellular events. However, the regulatory molecule(s) and underlying mechanism(s) remain poorly understood. Herein, we sought to better understand this event by using an adjudin-based animal model. Adult rats were treated with

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Bhatnagar, Rajendra S., Steven B. Nicoll, Jing Jing Qian, and Nancy Smith. "A Tissue Engineering Model for Tractional Organization of Cells and Matrices." Microscopy and Microanalysis 7, S2 (2001): 122–23. http://dx.doi.org/10.1017/s1431927600026684.

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Tissues are characterized by highly distinctive microarchitecture and overall form that are critical to tissue specific function. with increasing interest in tissue engineering to create surrogates for human tissues and organs, innovative techniques have been developed to generate scaffolds that display form, and microarchitecture mimicking physiological structures. While this artifice may generate pre-programmed shapes, it fails to take advantage of the inherent ability of cells to organize themselves and their surroundings. The generation of mechanical forces by the cellular cytoskeleton pla

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Breuer, David, Alexander Ivakov, Arun Sampathkumar, Florian Hollandt, Staffan Persson, and Zoran Nikoloski. "Quantitative analyses of the plant cytoskeleton reveal underlying organizational principles." Journal of The Royal Society Interface 11, no. 97 (2014): 20140362. http://dx.doi.org/10.1098/rsif.2014.0362.

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The actin and microtubule (MT) cytoskeletons are vital structures for cell growth and development across all species. While individual molecular mechanisms underpinning actin and MT dynamics have been intensively studied, principles that govern the cytoskeleton organization remain largely unexplored. Here, we captured biologically relevant characteristics of the plant cytoskeleton through a network-driven imaging-based approach allowing us to quantitatively assess dynamic features of the cytoskeleton. By introducing suitable null models, we demonstrate that the plant cytoskeletal networks exhi

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Pathak, Amit, Vikram S. Deshpande, Robert M. McMeeking, and Anthony G. Evans. "The simulation of stress fibre and focal adhesion development in cells on patterned substrates." Journal of The Royal Society Interface 5, no. 22 (2007): 507–24. http://dx.doi.org/10.1098/rsif.2007.1182.

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The remodelling of the cytoskeleton and focal adhesion (FA) distributions for cells on substrates with micro-patterned ligand patches is investigated using a bio-chemo-mechanical model. We investigate the effect of ligand pattern shape on the cytoskeletal arrangements and FA distributions for cells having approximately the same area. The cytoskeleton model accounts for the dynamic rearrangement of the actin/myosin stress fibres. It entails the highly nonlinear interactions between signalling, the kinetics of tension-dependent stress-fibre formation/dissolution and stress-dependent contractilit

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Saito, Fumiyasu, Yohsuke Imai, Shunichi Ishida, Toshihiro Omori, and Takuji Ishikawa. "PS3-7 DEVELOPMENT OF A NUMERICAL MODEL OF CYTOSKELETON DYNAMICS(PS3: Poster Short Presentation III,Poster Session)." Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics 2015.8 (2015): 268. http://dx.doi.org/10.1299/jsmeapbio.2015.8.268.

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Loiseau, Etienne, Jochen A. M. Schneider, Felix C. Keber, et al. "Shape remodeling and blebbing of active cytoskeletal vesicles." Science Advances 2, no. 4 (2016): e1500465. http://dx.doi.org/10.1126/sciadv.1500465.

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Morphological transformations of living cells, such as shape adaptation to external stimuli, blebbing, invagination, or tethering, result from an intricate interplay between the plasma membrane and its underlying cytoskeleton, where molecular motors generate forces. Cellular complexity defies a clear identification of the competing processes that lead to such a rich phenomenology. In a synthetic biology approach, designing a cell-like model assembled from a minimal set of purified building blocks would allow the control of all relevant parameters. We reconstruct actomyosin vesicles in which th

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Alisafaei, Farid, Doorgesh Sharma Jokhun, G. V. Shivashankar, and Vivek B. Shenoy. "Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints." Proceedings of the National Academy of Sciences 116, no. 27 (2019): 13200–13209. http://dx.doi.org/10.1073/pnas.1902035116.

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Cells sense mechanical signals from their microenvironment and transduce them to the nucleus to regulate gene expression programs. To elucidate the physical mechanisms involved in this regulation, we developed an active 3D chemomechanical model to describe the three-way feedback between the adhesions, the cytoskeleton, and the nucleus. The model shows local tensile stresses generated at the interface of the cell and the extracellular matrix regulate the properties of the nucleus, including nuclear morphology, levels of lamin A,C, and histone deacetylation, as these tensile stresses 1) are tran

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Al-Mamun, Mohammed, Lorna Ravenhill, Worawut Srisukkham, et al. "Effects of Noninhibitory Serpin Maspin on the Actin Cytoskeleton: A Quantitative Image Modeling Approach." Microscopy and Microanalysis 22, no. 2 (2016): 394–409. http://dx.doi.org/10.1017/s1431927616000520.

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AbstractRecent developments in quantitative image analysis allow us to interrogate confocal microscopy images to answer biological questions. Clumped and layered cell nuclei and cytoplasm in confocal images challenges the ability to identify subcellular compartments. To date, there is no perfect image analysis method to identify cytoskeletal changes in confocal images. Here, we present a multidisciplinary study where an image analysis model was developed to allow quantitative measurements of changes in the cytoskeleton of cells with different maspin exposure. Maspin, a noninhibitory serpin inf

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Keković, G., D. Raković, M. V. Satarić, and Dj Koruga. "A Kink-Soliton Model of Charge Transport through Microtubular Cytoskeleton." Materials Science Forum 494 (September 2005): 507–12. http://dx.doi.org/10.4028/www.scientific.net/msf.494.507.

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Contemporary trends in science and technology are characterized by integration of biological and technical systems, like in nanotechnology, nanobiology, and quantum medicine. In our case, we were motivated by a necessity to understand charge transport through microtubular cytoskeleton as a constitutive part of acupuncture system. The high frequency component of acupuncture currents, widely exploited in microwave resonance stimulation of acupuncture system in the past decade, implies that explanation of the cytoplasmatic conductivity should be sought in the framework of Frohlich theory. Accordi

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Coughlin, Mark F., and Dimitrije Stamenović. "A Prestressed Cable Network Model of the Adherent Cell Cytoskeleton." Biophysical Journal 84, no. 2 (2003): 1328–36. http://dx.doi.org/10.1016/s0006-3495(03)74948-0.

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Boal, D. H. "Computer simulation of a model network for the erythrocyte cytoskeleton." Biophysical Journal 67, no. 2 (1994): 521–29. http://dx.doi.org/10.1016/s0006-3495(94)80511-9.

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Gong, Jinghai, Daxu Zhang, Yiider Tseng, Baolong Li, Denis Wirtz, and Benjamin William Schafer. "Form-Finding Model Shows How Cytoskeleton Network Stiffness Is Realized." PLoS ONE 8, no. 10 (2013): e77417. http://dx.doi.org/10.1371/journal.pone.0077417.

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Wang, Shenshen, and Peter G. Wolynes. "Tensegrity and motor-driven effective interactions in a model cytoskeleton." Journal of Chemical Physics 136, no. 14 (2012): 145102. http://dx.doi.org/10.1063/1.3702583.

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LEE, David, Kikuo KISHIMOTO, Tadaharu ADACHI, and Atsushi IKAI. "749 A Network Model of Active Processes in the Cytoskeleton." Proceedings of The Computational Mechanics Conference 2008.21 (2008): 862–63. http://dx.doi.org/10.1299/jsmecmd.2008.21.862.

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Inoue, Yasuhiro, Taiji Adachi, and Masaki Hojo. "2010 Thermodynamic model of mechanoresponsive binding of cytoskeleton-regulatory proteins." Proceedings of The Computational Mechanics Conference 2009.22 (2009): 761–62. http://dx.doi.org/10.1299/jsmecmd.2009.22.761.

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Campillo, Clément, Léa-Laetitia Pontani, Pierre Nassoy, Patricia Bassereau, and Cécile Sykes. "Nanotether Extrusion to probe Membrane-Cytoskeleton Interaction in Model Systems." Biophysical Journal 96, no. 3 (2009): 386a. http://dx.doi.org/10.1016/j.bpj.2008.12.2891.

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Fan, Houfu, and Shaofan Li. "Modeling microtubule cytoskeleton via an active liquid crystal elastomer model." Computational Materials Science 96 (January 2015): 559–66. http://dx.doi.org/10.1016/j.commatsci.2014.04.041.

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Maurin, B., P. Cañadas, H. Baudriller, P. Montcourrier, and N. Bettache. "Mechanical model of cytoskeleton structuration during cell adhesion and spreading." Journal of Biomechanics 41, no. 9 (2008): 2036–41. http://dx.doi.org/10.1016/j.jbiomech.2008.03.011.

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Loosli, Y., R. Luginbuehl, and J. G. Snedeker. "Cytoskeleton reorganization of spreading cells on micro-patterned islands: a functional model." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368, no. 1920 (2010): 2629–52. http://dx.doi.org/10.1098/rsta.2010.0069.

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Predictive numerical models of cellular response to biophysical cues have emerged as a useful quantitative tool for cell biology research. Cellular experiments in silico can augment in vitro and in vivo investigations by filling gaps in what is possible to achieve through ‘wet work’. Biophysics-based numerical models can be used to verify the plausibility of mechanisms regulating tissue homeostasis derived from experiments. They can also be used to explore potential targets for therapeutic intervention. In this perspective article we introduce a single cell model developed towards the design o

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