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1

Cantoni, Valeria, Roberta Green, Carlo Ricciardi, et al. "Comparing the Prognostic Value of Stress Myocardial Perfusion Imaging by Conventional and Cadmium-Zinc Telluride Single-Photon Emission Computed Tomography through a Machine Learning Approach." Computational and Mathematical Methods in Medicine 2021 (October 16, 2021): 1–8. http://dx.doi.org/10.1155/2021/5288844.

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We compared the prognostic value of myocardial perfusion imaging (MPI) by conventional- (C-) single-photon emission computed tomography (SPECT) and cadmium-zinc-telluride- (CZT-) SPECT in a cohort of patients with suspected or known coronary artery disease (CAD) using machine learning (ML) algorithms. A total of 453 consecutive patients underwent stress MPI by both C-SPECT and CZT-SPECT. The outcome was a composite end point of all-cause death, cardiac death, nonfatal myocardial infarction, or coronary revascularization procedures whichever occurred first. ML analysis performed through the imp
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2

Bouchareb, Yassine, Afrah AlSaadi, Jawa Zabah, et al. "Technological Advances in SPECT and SPECT/CT Imaging." Diagnostics 14, no. 13 (2024): 1431. http://dx.doi.org/10.3390/diagnostics14131431.

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Single photon emission tomography/computed tomography (SPECT/CT) is a mature imaging technology with a dynamic role in the diagnosis and monitoring of a wide array of diseases. This paper reviews the technological advances, clinical impact, and future directions of SPECT and SPECT/CT imaging. The focus of this review is on signal amplifier devices, detector materials, camera head and collimator designs, image reconstruction techniques, and quantitative methods. Bulky photomultiplier tubes (PMTs) are being replaced by position-sensitive PMTs (PSPMTs), avalanche photodiodes (APDs), and silicon P
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Weng, Fenghua, Srijeeta Bagchi, Yunlong Zan, Qiu Huang, and Youngho Seo. "An energy-optimized collimator design for a CZT-based SPECT camera." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 806 (January 2016): 330–39. http://dx.doi.org/10.1016/j.nima.2015.09.115.

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4

Duvall, W. Lane, Lori B. Croft, Tapan Godiwala, Eric Ginsberg, Titus George, and Milena J. Henzlova. "Reduced isotope dose with rapid SPECT MPI imaging: Initial experience with a CZT SPECT camera." Journal of Nuclear Cardiology 17, no. 6 (2010): 1009–14. http://dx.doi.org/10.1007/s12350-010-9215-5.

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5

Yoo, Ik Dong, In Young Jo, Geum Cheol Jeong, Yong Kyun Won, Du Shin Jeong, and Sang Mi Lee. "Quantitative Scintigraphy Imaging of Lingual Raynaud’s Phenomenon Using 3-Dimensional-Ring Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography/Computed Tomography." Tomography 8, no. 4 (2022): 2042–48. http://dx.doi.org/10.3390/tomography8040171.

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Perfusion scintigraphy with the acquisition of planar blood flow and pool images of bilateral hands has been used to aid diagnosis and to evaluate treatment response to Raynaud’s phenomenon (decreased blood flow to hand or foot). However, because of the difficulty in imaging the tongue area with a conventional gamma camera, perfusion scintigraphy imaging of patients with lingual Raynaud’s phenomenon has yet to be reported. Here, we report the case of a 59-year-old man with lingual Raynaud’s phenomenon in which blood pool imaging of the tongue was performed using three-dimensional (3D)-ring cad
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6

Hansen, Maria Normand, Christian Haarmark, Bent Kristensen, and Bo Zerahn. "An Algorithm for Individual Dosage in Cadmium–Zinc–Telluride SPECT-Gated Radionuclide Angiography." Diagnostics 11, no. 12 (2021): 2268. http://dx.doi.org/10.3390/diagnostics11122268.

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The aim of the present study was to test an individualised dose without compromising the ease of analysing data when performing equilibrium radionuclide angiography (ERNA) using cadmium–zinc–telluride (CZT) SPECT. From March 2018 to January 2019, 1650 patients referred for ERNA received either an individualised dose of 99mTc-labeled human serum albumin (HSA) according to their age, sex, height, and weight (n = 1567), or a standard dose of 550 MBq (n = 83). The target count rate (CRT) was reduced every two months from 2.7 to 1.0 kcps. A final test with a CRT of 1.7 kcps was run for three months
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7

Boutaghane, Nasreddine, Michel Hesse, Boualem Bouzid, Habib Zaidi, François Jamar, and Stephan Walrand. "Dual-layer collimator for improved spatial resolution in SPECT with CZT camera: an analytical and Monte Carlo study." Physics in Medicine & Biology 67, no. 6 (2022): 065006. http://dx.doi.org/10.1088/1361-6560/ac5671.

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Abstract Purpose. Current hole matching pixel detector (HMPD) collimators for SPECT imaging exist in two configurations: one hole per pixel (1HMPD) or four holes per pixel (4HMPD). The aim of this study was to assess the performance of a dual-layer collimator made by stacking up these two collimator types (1H/4HMDP) for low- and medium energy gamma emitters. Method. Analytical equations describing geometrical efficiency and full width at half maximum (FWHM) of the 1H/4HMDP collimator were derived. In addition, a fast dedicated Monte Carlo (MC) code neglecting scattering and designed for the co
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8

Duvall, W. Lane, Lori B. Croft, Eric S. Ginsberg, et al. "Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera." Journal of Nuclear Cardiology 18, no. 5 (2011): 847–57. http://dx.doi.org/10.1007/s12350-011-9379-7.

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9

Hindorf, Cecilia, Jenny Oddstig, Fredrik Hedeer, Magnus J. Hansson, Jonas Jögi, and Henrik Engblom. "Importance of correct patient positioning in myocardial perfusion SPECT when using a CZT camera." Journal of Nuclear Cardiology 21, no. 4 (2014): 695–702. http://dx.doi.org/10.1007/s12350-014-9897-1.

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10

Aleksa, Gytis, Paulius Jaruševičius, Andrė Pacaitytė, and Donatas Vajauskas. "Comparative Analysis of Cardiac SPECT Myocardial Perfusion Imaging: Full-Ring Solid-State Detectors Versus Dedicated Cardiac Fixed-Angle Gamma Camera." Medicina 61, no. 4 (2025): 665. https://doi.org/10.3390/medicina61040665.

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Background and Objectives: Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is a well-established technique for evaluating myocardial perfusion and function in patients with suspected or known coronary artery disease. While conventional dual-detector SPECT scanners have limitations in spatial resolution and photon detection sensitivity, recent advancements, including full-ring solid-state cadmium zinc telluride (CZT) detectors, offer enhanced image quality and improved diagnostic accuracy. This study aimed to compare the performance of Veriton-CT, a full-ri
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11

Yoo, Ik Dong, Sun-pyo Hong, Sang Mi Lee, et al. "Diagnostic Ability of Quantitative Parameters of Whole-Body Bone SPECT/CT Using a Full-Ring 360° Cadmium-Zinc-Telluride Camera for Detecting Bone Metastasis in Patients with Prostate Cancer." Diagnostics 14, no. 23 (2024): 2714. https://doi.org/10.3390/diagnostics14232714.

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Background/Objectives: This study aimed to assess the diagnostic capability of quantitative parameters from whole-body bone single-photon emission computed tomography/computed tomography (SPECT/CT) in detecting bone metastases in prostate cancer patients; Methods: We retrospectively analyzed 82 prostate cancer patients who underwent staging bone scintigraphy with a full-ring 360° Cadmium-Zinc-Telluride (CZT) SPECT/CT system. From the SPECT/CT images, we measured the maximum (SUVmax) and mean (SUVmean) standardized uptake values at six normal bone sites (skull, humerus, thoracic spine, lumbar s
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12

Lima, Ronaldo, Thais Peclat, Thalita Soares, Caio Ferreira, Ana Carolina Souza, and Gabriel Camargo. "Comparison of the prognostic value of myocardial perfusion imaging using a CZT-SPECT camera with a conventional anger camera." Journal of Nuclear Cardiology 24, no. 1 (2016): 245–51. http://dx.doi.org/10.1007/s12350-016-0618-9.

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13

Piatkova, Yuliya, Pierre Payoux, Caroline Boursier, et al. "Prospective Paired Comparison of 123I-FP-CIT SPECT Images Obtained With a 360°-CZT and a Conventional Camera." Clinical Nuclear Medicine 47, no. 1 (2022): 14–20. http://dx.doi.org/10.1097/rlu.0000000000003969.

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14

Lima, Ronaldo S. L., Thaís R. Peclat, Ana Carolina A. H. Souza, et al. "Prognostic value of a faster, low-radiation myocardial perfusion SPECT protocol in a CZT camera." International Journal of Cardiovascular Imaging 33, no. 12 (2017): 2049–56. http://dx.doi.org/10.1007/s10554-017-1202-3.

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15

ASLAM, S., U. ASLAM, K. AHMED, S. ASLAM, M. KALEEM, and S. ASLAM. "MYOCARDIAL FLOW RESERVE MEASUREMENT USING CADMIUM ZINC-TELLURIDE SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY MYOCARDIAL PERFUSION IMAGING AND RELATION TO ANGIOGRAPHIC CORONARY ARTERY DISEASE." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1426. https://doi.org/10.54112/bcsrj.v2024i1.1426.

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The addition of Myocardial flow reserve (MFR) to Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI) by using Cadmium Zinc Telluride (CZT) camera for screening of CAD may improve high-risk patient identification and diagnostic performance. Objective: This study aimed to assess the severity of coronary artery disease using MFR by SPECT MPI and comparing it with angiography finding. Methods: It was a cross-sectional study which was carried out in Armed Forces institute of cardiology and National Institute of Heart Diseases, Rawalpindi from June to Oct 2024. The
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16

Bordonne, Manon, Pierre-Yves Marie, Laetitia Imbert, and Antoine Verger. "Brain perfusion SPECT acquired using a dedicated brain configuration on a 360° whole-body CZT-camera." Journal of Neuroradiology 47, no. 2 (2020): 180–81. http://dx.doi.org/10.1016/j.neurad.2019.11.002.

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17

Legallois, Damien, Laure Champ-Rigot, Benjamin Houdu, Denis Agostini, and Alain Manrique. "Ventricular arrhythmia originating from scar border tissue during dobutamine myocardial perfusion gated SPECT on CZT camera." Journal of Nuclear Cardiology 23, no. 4 (2015): 854–55. http://dx.doi.org/10.1007/s12350-015-0356-4.

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18

Verger, Antoine, Laetitia Imbert, Yalcine Yagdigul, et al. "Factors affecting the myocardial activity acquired during exercise SPECT with a high-sensitivity cardiac CZT camera as compared with conventional Anger camera." European Journal of Nuclear Medicine and Molecular Imaging 41, no. 3 (2013): 522–28. http://dx.doi.org/10.1007/s00259-013-2617-2.

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19

Zeng, Gengsheng L., and Daniel Gagnon. "Image reconstruction algorithm for a spinning strip CZT SPECT camera with a parallel slat collimator and small pixels." Medical Physics 31, no. 12 (2004): 3461–73. http://dx.doi.org/10.1118/1.1813873.

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20

van Dijk, Joris D., Jorn A. van Dalen, Mohamed Mouden, et al. "Value of automatic patient motion detection and correction in myocardial perfusion imaging using a CZT-based SPECT camera." Journal of Nuclear Cardiology 25, no. 2 (2016): 419–28. http://dx.doi.org/10.1007/s12350-016-0571-7.

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21

Jurczak, J., L. Imbert, G. Karcher, and P. Y. Marie. "P2. Impact of the modelling of charge collection on the simulation of SPECT recordings from CZT semiconductors camera." Physica Medica 32 (December 2016): 367–68. http://dx.doi.org/10.1016/j.ejmp.2016.11.014.

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22

Ben Bouallègue, Fayçal, Catherine Nganoa, Jonathan Vigne, Denis Agostini, and Alain Manrique. "Comparative Performances of Dipyridamole and Regadenoson to Detect Myocardial Ischemia using Cardiac Cadmium-Zinc-Telluride Single-Photon Emission Computerized Tomography." Journal of Clinical Imaging Science 8 (November 15, 2018): 51. http://dx.doi.org/10.4103/jcis.jcis_71_17.

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Objective: We evaluated the relative performances of dipyridamole (Dip) and regadenoson (Reg) in a cohort of patients referred for coronary artery disease diagnosis or follow-up using myocardial perfusion imaging. Materials and Methods: We retrospectively included 515 consecutive patients referred for 99mTc-sestamibi myocardial perfusion single-photon emission computerized tomography (SPECT) on a cadmium-zinc-telluride (CZT) camera after pharmacologic stress. About three quarters (n = 391, 76%) received Dip. Reg was administrated to patients with chronical respiratory disease or with body mass
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23

Franc, Benjamin L., Yonggang Cui, Seth A. Rosenthal, et al. "Improved techniques to localize foci of carcinoma within the prostate using high-resolution transrectal gamma imaging (TRGI) of monoclonal antibody directed at prostate specific membrane antigen (PSMA)." Journal of Clinical Oncology 30, no. 15_suppl (2012): e21026-e21026. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e21026.

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e21026 Background: As many as 40% of prostate cancers may be missed on biopsy, necessitating novel methods for biopsy guidance. There is also interest in mapping primary prostate cancers for treatment. The presented work evaluated the ability of a transrectal gamma-imaging (TRGI) device to detect and localize a prostate-specific membrane antigen (PSMA) - specific radiopharmaceutical in the prostate. Methods: The IRB approved this exploratory proof-of-concept study. Male patients with untreated, biopsy-proven prostatic adenocarcinoma received 5±0.5 mCi In-111 capromab pendetide (Prostascint, a
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24

Chevalier, Elodie, Caroline Boursier, Marine Claudin, Pierre-Yves Marie, and Laetitia Imbert. "Feasibility of 177Lu Therapy Monitoring Using Fast Whole-Body SPECT Recordings Provided by a High-Speed 360° CZT Camera." Clinical Nuclear Medicine 45, no. 11 (2020): e493-e494. http://dx.doi.org/10.1097/rlu.0000000000003169.

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25

Luo, J., N. Deitz, D. Pantelic, D. Cowling, and S. Jang. "SU-E-I-179: Evaluation of a SPECT Camera with CZT Detectors and Multipinhole Collimator for Nuclear Cardiology Imaging." Medical Physics 38, no. 6Part6 (2011): 3437. http://dx.doi.org/10.1118/1.3611753.

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26

Mouden, Mohamed, Jorik R. Timmer, Jan Paul Ottervanger, et al. "Impact of a new ultrafast CZT SPECT camera for myocardial perfusion imaging: fewer equivocal results and lower radiation dose." European Journal of Nuclear Medicine and Molecular Imaging 39, no. 6 (2012): 1048–55. http://dx.doi.org/10.1007/s00259-012-2086-z.

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27

Cichocki, Paweł, Michał Błaszczyk, Kamila Cygulska, et al. "Inter- and Intraobserver Repeatability of Myocardial Flow Reserve Values Determined with SPECT Study Using a Discovery NM530c Camera and Corridor 4DM Software." Journal of Personalized Medicine 11, no. 11 (2021): 1164. http://dx.doi.org/10.3390/jpm11111164.

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Background: Myocardial blood flow (MBF) and flow reserve (MFR) examination, especially useful in the diagnosis of multivessel coronary artery disease (CAD), can be assessed with a cadmium-zinc-telluride (CZT) SPECT gamma camera, as an alternative to the expensive and less available PET. However, study processing is not free from subjective factors. Therefore, this paper aims to evaluate intra- and interobserver repeatability of MBF and MFR values obtained by the same operator and two independent operators. Methods: This study included 57 adult patients. MBF and MFR were assessed using a Discov
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Fiorino, M., C. Morizot, A. Bahloul, et al. "POS0129 WHOLE-BODY SPECT-CT CzT-BASED CAMERA (VERITON-CT) VERSUS MRI IN THE ASSESSMENT OF SACROILIITIS IN SPONDYLOARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 84 (June 2025): 421. https://doi.org/10.1016/j.ard.2025.05.517.

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Esteves, Fabio P., James R. Galt, Russell D. Folks, Liudmila Verdes, and Ernest V. Garcia. "Diagnostic performance of low-dose rest/stress Tc-99m tetrofosmin myocardial perfusion SPECT using the 530c CZT camera: Quantitative vs visual analysis." Journal of Nuclear Cardiology 21, no. 1 (2013): 158–65. http://dx.doi.org/10.1007/s12350-013-9827-7.

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Wells, RG, K. Vanderwerf, I. Ali, and TD Ruddy. "Poster - Thur Eve - 02: Evaluation of Cross-Talk for Dual-Isotope Myocardial Perfusion Imaging Using a New Dedicated Cardiac CZT SPECT Camera." Medical Physics 37, no. 7Part1 (2010): 3886. http://dx.doi.org/10.1118/1.3476107.

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Melki, Saifeddine, Mohammad Bilal Chawki, Pierre-Yves Marie, Laetitia Imbert, and Antoine Verger. "Augmented planar bone scintigraphy obtained from a whole-body SPECT recording of less than 20 min with a high-sensitivity 360° CZT camera." European Journal of Nuclear Medicine and Molecular Imaging 47, no. 5 (2019): 1329–31. http://dx.doi.org/10.1007/s00259-019-04525-y.

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Morelle, Maxime, Dimitri Bellevre, Claude Hossein-Foucher, Alain Manrique, and Alban Bailliez. "First comparison of performances between the new whole-body cadmium–zinc–telluride SPECT-CT camera and a dedicated cardiac CZT camera for myocardial perfusion imaging: Analysis of phantom and patients." Journal of Nuclear Cardiology 27, no. 4 (2019): 1261–69. http://dx.doi.org/10.1007/s12350-019-01702-2.

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33

Giorgetti, Assuero, Pier Giorgio Masci, Gavino Marras, et al. "Gated SPECT evaluation of left ventricular function using a CZT camera and a fast low-dose clinical protocol: comparison to cardiac magnetic resonance imaging." European Journal of Nuclear Medicine and Molecular Imaging 40, no. 12 (2013): 1869–75. http://dx.doi.org/10.1007/s00259-013-2505-9.

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Legagneur, Corinne, Loïc Djaileb, Caroline Sagnes, et al. "0005 : Prognostic value of myocardial perfusion SPECT without significant perfusion defect using a dual isotope protocol and a novel CZT camera: interim results of the PROMHETE study." Archives of Cardiovascular Diseases Supplements 8, no. 3 (2016): 254. http://dx.doi.org/10.1016/s1878-6480(16)30499-2.

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Bailliez, Alban, Tanguy Blaire, Frédéric Mouquet, et al. "Segmental and global left ventricular function assessment using gated SPECT with a semiconductor Cadmium Zinc Telluride (CZT) camera: Phantom study and clinical validation vs cardiac magnetic resonance." Journal of Nuclear Cardiology 21, no. 4 (2014): 712–22. http://dx.doi.org/10.1007/s12350-014-9899-z.

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Sharir, Tali, Marina Pinskiy, Abraham Pardes, et al. "Comparison of the diagnostic accuracies of very low stress-dose with standard-dose myocardial perfusion imaging: Automated quantification of one-day, stress-first SPECT using a CZT camera." Journal of Nuclear Cardiology 23, no. 1 (2015): 11–20. http://dx.doi.org/10.1007/s12350-015-0130-7.

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37

Hyafil, Fabien, Renata Chequer, Emmanuel Sorbets, et al. "Head-to-head comparison of the diagnostic performances of Rubidium-PET and SPECT with CZT camera for the detection of myocardial ischemia in a population of women and overweight individuals." Journal of Nuclear Cardiology 27, no. 3 (2018): 755–68. http://dx.doi.org/10.1007/s12350-018-01557-z.

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38

Yamamoto, Atsushi, Michinobu Nagao, Kiyoe Ando, et al. "First Validation of Myocardial Flow Reserve Derived from Dynamic <sup>99m</sup>Tc-Sestamibi CZT-SPECT Camera Compared with <sup>13</sup>N-Ammonia PET." International Heart Journal 63, no. 2 (2022): 202–9. http://dx.doi.org/10.1536/ihj.21-487.

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39

D’estanque, Emmanuel, Christophe Hedon, Benoît Lattuca, et al. "Optimization of a simultaneous dual-isotope 201Tl/123I-MIBG myocardial SPECT imaging protocol with a CZT camera for trigger zone assessment after myocardial infarction for routine clinical settings: Are delayed acquisition and scatter correction necessary?" Journal of Nuclear Cardiology 24, no. 4 (2016): 1361–69. http://dx.doi.org/10.1007/s12350-016-0524-1.

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Agostini, Denis, Vincent Roule, Catherine Nganoa, et al. "First validation of myocardial flow reserve assessed by dynamic 99mTc-sestamibi CZT-SPECT camera: head to head comparison with 15O-water PET and fractional flow reserve in patients with suspected coronary artery disease. The WATERDAY study." European Journal of Nuclear Medicine and Molecular Imaging 45, no. 7 (2018): 1079–90. http://dx.doi.org/10.1007/s00259-018-3958-7.

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Chen, Yue, Zekun Pang, Jiao Wang, Xuewen Yang, and Jianming Li. "Evaluation of biventricular function by cadmium–zinc–telluride SPECT gated tomographic radionuclide angiography: Comparison to conventional SPECT." Medicine 103, no. 39 (2024): e39821. http://dx.doi.org/10.1097/md.0000000000039821.

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We compared and analyzed the consistency and repeatability of left and right ventricular ((LV/RV) functions obtained by gated-equilibrium radionuclide ventriculography (ERNV) with cadmium–zinc–telluride single-photon emission computed tomography (CZT-SPECT) and conventional SPECT (C-SPECT) with sodium iodide crystal detectors. Seventy-seven patients were included in the retrospective study. Both C-SPECT and CZT-SPECT imaging were performed on the same day. Correlations and differences in LV/RV ejection fraction (LVEF and RVEF), peak ejection rate (PER), and peak filling rate (PFR) were compare
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Kalantari, Forough, Nasibeh Mohseninia, Andreas Wetsch, et al. "Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance." Life 13, no. 9 (2023): 1879. http://dx.doi.org/10.3390/life13091879.

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Background: Myocardial perfusion imaging (MPI) plays a crucial role in diagnosing coronary artery disease (CAD), with single-photon emission computed tomography (SPECT) being a widely accepted method. The accuracy of MPI relies on image quality and the expertise of physicians. While CZT-SPECT cameras offer advantages, they can be susceptible to attenuation artifacts. Therefore, our objective was to evaluate the diagnostic accuracy of CZT-SPECT and SPECT/CT in a clinical setting. Method: We conducted a prospective single-center study involving patients with known or suspected stable ischemic he
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Imbert, Laetitia, and Pierre-Yves Marie. "CZT cameras: A technological jump for myocardial perfusion SPECT." Journal of Nuclear Cardiology 23, no. 4 (2015): 894–96. http://dx.doi.org/10.1007/s12350-015-0216-2.

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44

Bordonne, Manon, Mohammad B. Chawki, Pierre-Yves Marie, et al. "High-quality brain perfusion SPECT images may be achieved with a high-speed recording using 360° CZT camera." EJNMMI Physics 7, no. 1 (2020). http://dx.doi.org/10.1186/s40658-020-00334-7.

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Abstract Objective The aim of this study was to compare brain perfusion SPECT obtained from a 360° CZT and a conventional Anger camera. Methods The 360° CZT camera utilizing a brain configuration, with 12 detectors surrounding the head, was compared to a 2-head Anger camera for count sensitivity and image quality on 30-min SPECT recordings from a brain phantom and from 99mTc-HMPAO brain perfusion in 2 groups of 21 patients investigated with the CZT and Anger cameras, respectively. Image reconstruction was adjusted according to image contrast for each camera. Results The CZT camera provided mor
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45

Thiele, Felix, Franziska Schau, Julian M. M. Rogasch, et al. "Same same but different: dopamine transporter SPECT on scanners with CZT vs. NaI detectors." EJNMMI Research 13, no. 1 (2023). http://dx.doi.org/10.1186/s13550-023-00973-8.

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Abstract Background The aims of this study were to establish a normal database (NDB) for semiquantification of dopamine transporter (DAT) single-photon emission computed tomography (SPECT) with [123I]FP-CIT on a cadmium zinc telluride (CZT) camera, test the preexisting NaI-derived NDB for use in CZT scans, and compare the diagnostic findings in subjects imaged with a CZT scanner with either the preexisting NaI-based NDB or our newly defined CZT NDB. Methods The sample comprised 73 subjects with clinically uncertain parkinsonian syndrome (PS) who prospectively underwent [123I]FP-CIT SPECT on a
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Aguade-Bruix, S., A. Cardozo-Saavedra, A. Palomar Munoz, et al. "Improvement of myocardial perfusion SPECT studies with a cardio-dedicated CZT gamma camera. Comparison with an analogical SPECT/CT gamma camera." European Heart Journal - Cardiovascular Imaging 25, Supplement_1 (2024). http://dx.doi.org/10.1093/ehjci/jeae142.055.

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Abstract Aim To show the improvement in myocardial perfusion SPECT studies achieved in the year 2023 using a cardio-dedicated CZT gamma camera, compared to year 2021 when using an analogical SPECT/CT gamma camera. Methods We have collected data on nuclear cardiology care activity for the years 2021, 2022 and 2023, including patients treated in our institution. In 2021 myocardial perfusion imaging (MPI) studies were performed primarily on an analogical SPECT/CT gamma camera, which was replaced by a cardio-dedicated CZT in 2022. In 2023 MPI was carried out mainly in the new CZT gamma camera. For
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Hesse, Michel, Florian Dupont, Nizar Mourad, et al. "Kidney dynamic SPECT acquisition on a CZT swiveling-detector ring camera: an in vivo pilot study." BMC Medical Imaging 24, no. 1 (2024). http://dx.doi.org/10.1186/s12880-024-01271-y.

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Abstract Background Large field of view CZT SPECT cameras with a ring geometry are available for some years now. Thanks to their good sensitivity and high temporal resolution, general dynamic SPECT imaging may be performed more easily, without resorting to dedicated systems. To evaluate the dynamic SPECT imaging by such cameras, we have performed an in vivo pilot study to analyze the kidney function of a pig and compare the results to standard dynamic planar imaging by a conventional gamma camera. Methods A 7-week-old (12 kg) female Landrace pig was injected with [99mTc]Tc-MAG3 and a 30 min dy
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Doyen, Matthieu, Gabriela Hossu, Sébastien Heyer, Timothée Zaragori, Laetitia Imbert, and Antoine Verger. "Identification of resting-state networks using dynamic brain perfusion SPECT imaging: A fSPECT case report." Frontiers in Human Neuroscience 17 (April 20, 2023). http://dx.doi.org/10.3389/fnhum.2023.1125765.

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Connectivity studies with nuclear medicine systems are scarce in literature. They mainly employ PET imaging and group level analyses due to the low temporal resolution of PET and especially SPECT imaging. Our current study analyses connectivity at an individual level using dynamic SPECT imaging, which has been enabled by the improved temporal resolution performances provided by the 360°CZT cameras. We present the case of an 80-year-old man referred for brain perfusion SPECT imaging for cognitive disorders for whom a dynamic SPECT acquisition was performed utilizing a 360°CZT camera (temporal s
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Aguade-Bruix, S., A. Cardozo Saavedra, E. Aguirre, et al. "Cut-off values of myocardial blood flow using cardiac-dedicated CZT SPECT." European Heart Journal - Cardiovascular Imaging 25, Supplement_1 (2024). http://dx.doi.org/10.1093/ehjci/jeae142.059.

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Abstract Background While not the primary mechanism or hallmark for the pathogenesis of all myocardial disease, coronary microvascular disease is acknowledged to play a crucial role in the diagnostic and prognosis of different diseases. PET is considered the non-invasive gold standard for evaluating myocardial blood flow, but SPECT-CZT cameras have become a promising and comparable tool for this purpose, more widespread in some countries. However, each SPECT-CZT trademark possesses different characteristics and each service adopts different protocols. This requires establishing specific cut-of
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D’Antonio, Adriana, Maria Falzarano, Fabrizio Reina, et al. "Cardiac Perfusion and Innervation Assessment by CZT-SPECT: Have a Look to Simultaneous Dual-isotope Protocol." Current Cardiovascular Imaging Reports, May 23, 2023. http://dx.doi.org/10.1007/s12410-023-09578-0.

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Abstract Purpose of Review The purpose of this review is to provide a summary on the status of the art of simultaneous perfusion-innervation imaging by CZT-SPECT and to clarify its potential applications in clinical practice. Recent Findings Introduction of CZT cameras represented a critical breakthrough in nuclear cardiology. Although it has been demonstrated that cardiac innervation may be easily assessed by CZT-SPECT, as for now, there are only few studies investigating cardiac perfusion and innervation with simultaneous dual-isotope imaging by CZT cameras. Summary Perfusion and innervation
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