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Journal articles on the topic 'D.B. Weiss'

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Published: 4 June 2021
Last updated: 5 February 2022

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1

Gong, Ruming, Ji Li, Elodie Pozzi, and Manasa N. Vempati. "Commutators on Weighted Morrey Spaces on Spaces of Homogeneous Type." Analysis and Geometry in Metric Spaces 8, no. 1 (January 1, 2020): 305–34. http://dx.doi.org/10.1515/agms-2020-0116.

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Abstract In this paper, we study the boundedness and compactness of the commutator of Calderón– Zygmund operators T on spaces of homogeneous type (X, d, µ) in the sense of Coifman and Weiss. More precisely, we show that the commutator [b, T] is bounded on the weighted Morrey space L ω p , k ( X ) L_\omega ^{p,k}\left( X \right) with κ ∈ (0, 1) and ω ∈ Ap (X), 1 < p < ∞, if and only if b is in the BMO space. We also prove that the commutator [b, T] is compact on the same weighted Morrey space if and only if b belongs to the VMO space. We note that there is no extra assumptions on the quasimetric d and the doubling measure µ.
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2

Collins, Brian. "Game of Thrones. Television. Season 5. Created by David Benioff and D. B. Weiss. HBO, 2013." Religious Studies Review 41, no. 4 (December 2015): 186. http://dx.doi.org/10.1111/rsr.12255_8.

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3

BURTON, ROBERT, and KYEWON K. PARK. "Spatial determinism for a freeZ2-action." Ergodic Theory and Dynamical Systems 32, no. 2 (December 16, 2011): 479–89. http://dx.doi.org/10.1017/s0143385711000770.

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AbstractWe extend the idea of bilateral determinism of a freeZ-action by D. Ornstein and B. Weiss to a freeZ2-action. We show that we have a ‘stronger’ spatial determinism forZ2-actions: to determine the completeZ2-name of a point, it is enough to know the name of a fraction of the orbit whose density can be made arbitrarily small. Moreover, for zero-entropyZ2-actions, we prove that there exists a partition$\tilde {\mathcal {P}}$such that the$\tilde {\mathcal {P}}$-names of an arbitrarily small one-sided cone determine the points.
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4

Pratt, M. M. "Stable complexes of axoplasmic vesicles and microtubules: protein composition and ATPase activity." Journal of Cell Biology 103, no. 3 (September 1, 1986): 957–68. http://dx.doi.org/10.1083/jcb.103.3.957.

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Fast transport of axonal vesicles and organelles is a microtubule-associated movement (Griffin, J. W., K. E. Fahnestock, L. Price, and P. N. Hoffman, 1983, J. Neuroscience, 3:557-566; Schnapp, B. J., R. D. Vale, M. P. Sheetz, and T. S. Reese, 1984, Cell, 40:455-462; Allen, R. D., D. G. Weiss, J. H. Hayden, D. T. Brown, H. Fujiwake, and M. Simpson, 1985, J. Cell Biol., 100:1736-1752). Proteins that mediate the interactions of axoplasmic vesicles and microtubules were studied using stable complexes of microtubules and vesicles (MtVC). These complexes formed spontaneously in vitro when taxol-stabilized microtubules were mixed with sonically disrupted axoplasm from the giant axon of the squid Loligo pealei. The isolated MtVCs contain a distinct subset of axoplasmic proteins, and are composed primarily of microtubules and attached membranous vesicles. The MtVC also contains nonmitochondrial ATPase activity. The binding of one high molecular mass polypeptide to the complex is significantly enhanced by ATP or adenyl imidodiphosphate. All of the axoplasmic proteins and ATPase activity that bind to microtubules are found in macromolecular complexes and appear to be vesicle-associated. These data allow the identification of several vesicle-associated proteins of the squid giant axon and suggest that one or more of these polypeptides mediates vesicle binding to microtubules.
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Petzer, J. H. "Contextual Evidence in Favour, of ΚАΥΧНΣΩМАІ in 1 Corinthians 13.3." New Testament Studies 35, no. 2 (April 1989): 229–53. http://dx.doi.org/10.1017/s0028688500024632.

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Four variants are listed in the apparatus of the 3rd corrected edition of the Greek New Testament (UBS3) in 1 Cor 13. 3. They are:κανχήσωμαı (P A B 048 pc)κανθήσωμαı (K ψ majority text)κανθήσομαı (C D F G L pc)κανθήσεταı (1877 2492 pc)Of these variants κανθσομαı seems to be the most popular, occurring in texts such as the 2nd edition of the British and Foreign Bible Societies, Vogels, Kilpatrick's Diglot, Von Soden, Tischendorf's 9th edition and the 25th edition of Nestle-Aland. It is also favoured by Elliott, De Boor, Grosheide, Godet, Morris, Bachmann, Billerbeck, Wolff, Weiss, Robertson and Plummer, Pop, Groenewald, Lietzmann, Barrett and Kieffer. Κανθήσωμαı seems to be the second most popular reading, occurring in amongst others the Textus Receptus, Alford, The Greek New Testament according to the Majority Text, Souter and Scrivener.
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6

Weiss, David S., Kiyoshi Takeda, Shizuo Akira, Arturo Zychlinsky, and Edgardo Moreno. "MyD88, but Not Toll-Like Receptors 4 and 2, Is Required for Efficient Clearance of Brucella abortus." Infection and Immunity 73, no. 8 (August 2005): 5137–43. http://dx.doi.org/10.1128/iai.73.8.5137-5143.2005.

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ABSTRACT It is not clear how the host initially recognizes and responds to infection by gram-negative pathogenic Brucella spp. It was previously shown (D. S. Weiss, B. Raupach, K. Takeda, S. Akira, and A. Zychlinsky, J. Immunol. 172:4463-4469, 2004) that the early macrophage response against gram-negative bacteria is mediated by Toll-like receptor 4 (TLR4), which signals in response to lipopolysaccharide (LPS). Brucella, however, has a noncanonical LPS which does not have potent immunostimulatory activity. We evaluated the kinetics of TLR4 activation and the cytokine response in murine macrophages after Brucella infection. We found that during infection of macrophages, Brucella avoids activation of TLR4 at 6 h but activates TLR4, TLR2, and myeloid differentiation factor 88 (MyD88) at 24 h postinfection. Interestingly, even though its activation is delayed, MyD88 is important for host defense against Brucella infection in vivo, since MyD88−/− mice do not clear the bacteria as efficiently as wild-type, TLR4−/−, TLR2−/−, or TLR4/TLR2−/− mice.
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7

Karin, N. J., Z. Kaprielian, and D. M. Fambrough. "Expression of avian Ca2+-ATPase in cultured mouse myogenic cells." Molecular and Cellular Biology 9, no. 5 (May 1989): 1978–86. http://dx.doi.org/10.1128/mcb.9.5.1978.

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cDNA encoding Ca2+-ATPase was cloned from a chicken skeletal muscle library. The cDNA (termed FCa) comprised 3,239 base pairs, including an open reading frame encoding 994 amino acids which showed the highest degree of homology with the adult rabbit fast-twitch Ca2+-ATPase isoform (C. J. Brandl, S. de Leon, D. R. Martin, and D. H. MacLennan, J. Biol. Chem. 262:3768-3774, 1987). Radiolabeled FCa hybridized to a 3.2-kilobase transcript in chicken skeletal muscle RNA but not to cardiac muscle RNA, which confirmed its identity as encoding the fast Ca2+-ATPase isoenzyme. FCa was transfected into the mouse myogenic line C2C12, from which a protein of 100 kilodaltons was immunopurified by using a monoclonal antibody specific for the avian fast Ca2+-ATPase. Immunofluorescence microscopy of a line (designated C2FCa2) stably expressing the avian Ca2+-ATPase localized the protein to the nuclear envelope and a population of cytoplasmic vesicles. A similar pattern was observed when C2FCa2 cells were stained with DiOC6(3), a cyanine dye that labels endoplasmic reticulum and mitochondria (M. Terasaki, J. Song, J. R. Wong, M. J. Weiss, and L. B. Chen, Cell 38:101-108, 1984). We conclude that the avian Ca2+-ATPase fast isoform is expressed and correctly targeted to the endoplasmic reticulum in mouse C2C12 cells.
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8

Karin, N. J., Z. Kaprielian, and D. M. Fambrough. "Expression of avian Ca2+-ATPase in cultured mouse myogenic cells." Molecular and Cellular Biology 9, no. 5 (May 1989): 1978–86. http://dx.doi.org/10.1128/mcb.9.5.1978-1986.1989.

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cDNA encoding Ca2+-ATPase was cloned from a chicken skeletal muscle library. The cDNA (termed FCa) comprised 3,239 base pairs, including an open reading frame encoding 994 amino acids which showed the highest degree of homology with the adult rabbit fast-twitch Ca2+-ATPase isoform (C. J. Brandl, S. de Leon, D. R. Martin, and D. H. MacLennan, J. Biol. Chem. 262:3768-3774, 1987). Radiolabeled FCa hybridized to a 3.2-kilobase transcript in chicken skeletal muscle RNA but not to cardiac muscle RNA, which confirmed its identity as encoding the fast Ca2+-ATPase isoenzyme. FCa was transfected into the mouse myogenic line C2C12, from which a protein of 100 kilodaltons was immunopurified by using a monoclonal antibody specific for the avian fast Ca2+-ATPase. Immunofluorescence microscopy of a line (designated C2FCa2) stably expressing the avian Ca2+-ATPase localized the protein to the nuclear envelope and a population of cytoplasmic vesicles. A similar pattern was observed when C2FCa2 cells were stained with DiOC6(3), a cyanine dye that labels endoplasmic reticulum and mitochondria (M. Terasaki, J. Song, J. R. Wong, M. J. Weiss, and L. B. Chen, Cell 38:101-108, 1984). We conclude that the avian Ca2+-ATPase fast isoform is expressed and correctly targeted to the endoplasmic reticulum in mouse C2C12 cells.
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9

Ordóñez Solís, David. "Crónica de la Jurisprudencia del Tribunal de Justicia de la Unión Europea." Cuadernos Europeos de Deusto, no. 60 (April 30, 2019): 343–83. http://dx.doi.org/10.18543/ced-60-2019pp343-383.

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Sumario: I. Introducción.—II . Primera parte. Los desarrollos jurisprudenciales del derecho de la Unión Europea. 1. Las bases constitucionales de la Unión ante el Tribunal de Justicia: el Brexit, la moneda única y los derechos fundamentales. a) Las condiciones soberanas del Brexit: la sentencia Wightman. b) El control de la Unión Económica y Monetaria: la sentencia Weiss. c) La distintas naturaleza del Derecho de la Unión y del Convenio Europeo de Derechos Humanos. 2. El mercado único europeo y las políticas de la Unión. a) El seguro de responsabilidad del automóvil. b) La igualdad en materia de seguridad social y el cambio de sexo. c) El derecho a las vacaciones y el permiso parental. d) La protección de los datos personales e) La protección de los empleados temporales. 3. Las personas en el espacio europeo de libertad, seguridad y justicia. a) La libre circulación en el espacio de Schengen. b) La solicitud de asilo en distintos países del Sistema Europeo Común de Asilo. c) Las excepciones a la ejecución de la orden europea de detención y entrega.—III . S egunda parte. La jurisprudencia europea provocada por los jueces españoles y sus efectos en el Derecho Interno 1. Las sentencias prejudiciales «españolas» a) Los límites de la protección de los empleados públicos temporales: sentencias Vernaza Ayovi, Viejobueno y de Diego Porras II b) La sentencia Saras Energía y la eficiencia energética c) El alcance de la protección social europea: las sentencias González Castro, Crespo Rey, Checa Honrado, Colino Sigüenza e Ilunión Seguridad d) La sentencia Escobedo Cortés y la sentencia Bankia: las cláusulas abusivas y las prácticas comerciales desleales e) La sentencia Ministerio Fiscal y la protección de datos en la prevención e investigación de delitos 2. Las sanciones del Tribunal de Justicia a España por incumplir sentencias declarativas de incumplimiento a) La multa coercitiva y la suma a tanto alzado por incumplimiento del Derecho de la Unión b) Las correcciones financieras por incumplimiento del Derecho de la Unión en la gestión de los fondos europeos.—IV. Relación de las sentencias comentadas.
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10

Renner, Walter, Ingrid Salem, and Klaus Ottomeyer. "CROSS-CULTURAL VALIDATION OF MEASURES OF TRAUMATIC SYMPTOMS IN GROUPS OF ASYLUM SEEKERS FROM CHECHNYA, AFGHANISTAN, AND WEST AFRICA." Social Behavior and Personality: an international journal 34, no. 9 (January 1, 2006): 1101–14. http://dx.doi.org/10.2224/sbp.2006.34.9.1101.

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Internal consistencies and convergent validities of (a) the Hopkins Symptom Checklist-25 (HSCL-25; Mollica, Wyshak, deMarneffe, Khuon, & Lavelle, 1987), (b) the Harvard Trauma Questionnaire (HTQ; Mollica et al., 1992), (c) the Impact of Event Scale (IES-R; Weiss & Marmar, 1997), (d) the Bradford Somatic Inventory (BSI; Mumford et al., 1991), (e) the Clinician Administered PTSD Scale (CAPS-1; Blake et al., 1990), and (f) the Social Adaptation Self-Evaluation Scale (SASS; Bosc, Dubini, & Polin, 1997), were determined in 150 asylum seekers from Chechnya, Afghanistan, and West Africa using diagnostic interviews as a criterion. For all the instruments, except the SASS, estimates of internal consistency were satisfactory. When used as a continuous measure of symptom frequency and intensity, the CAPS-1 had excellent convergent validity for all three ethnic groups, while formal PTSD criteria yielded high numbers of false negative diagnoses. Among the questionnaires, for Chechnyans the HTQ, and for Afghans and West Africans the IES-R achieved best results with respect to convergent validity.
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11

Murphy, Stephen. "An Adaptation of Ice and Fire: D. B. Weiss and David Benioff ’s Television Adaptation of George R. R. Martin’s Unfilmable A Song of Ice and Fire." Film Matters 5, no. 2 (June 1, 2014): 84–86. http://dx.doi.org/10.1386/fm.5.2.84_1.

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12

Sofin, Mikhail, and Martin Jansen. "New Route of Preparation and Properties of NaNiO2." Zeitschrift für Naturforschung B 60, no. 6 (June 1, 2005): 701–4. http://dx.doi.org/10.1515/znb-2005-0615.

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NaNiO2 was prepared through oxidation of a Na2NiO2/ NiO mixture (1:1) in dried oxygen at 500 °C. Single crystals have been grown by annealing of NaNiO2 powder at 600 °C for 83 d in a flow of dried oxygen. According to the X-ray analysis of the crystal structure (C2/m, Z = 2, a = 5.3177(2), b = 2.8458(1), c = 5.5819(3) Å , β = 110.409(2)°, R1(all) = 3.4%, 185 independent reflections), the Jahn-Teller distorted NiO6 octahedra, sharing edges, build up layers lying parallel to the ab plane. A phase transition (associated with an energy of 2.9 kJ/mole) to a high temperature rhombohedral form (R3̅m, Z = 3, a = 2.958(1), c = 15.748(2) Å , at 300 °C) was observed by Guinier and DSC measurements at 195 °C. The magnetic susceptibility of the monoclinic phase can be described by the Curie-Weiss law between 100 and 330 K: μ = 2.01μB (g = 2.32), Θ = 37 K, indicating the dominance of ferromagnetic interactions of S = 1/2 spins within the NiO2 layers. Antiferromagnetic interlayer interactions produce an overall antiferromagnetically ordered structure below 18 K.
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13

Kato, Tomohiro, Yukari Uno, Hironao Ichikawa, Yuhei Iwasa, Chiemi Nakayama, Hideyuki Ogiso, Mitsuru Okuno, et al. "PS01.058: OLDER AGE AND DEMENTIA MIGHT BE CONSIDERED BACKGROUND FACTORS OF BLEEDING FROM EROSIVE REFLUX ESOPHAGITIS WITH ESOPHAGEAL ULCER." Diseases of the Esophagus 31, Supplement_1 (September 1, 2018): 66. http://dx.doi.org/10.1093/dote/doy089.ps01.058.

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Abstract Background Hematemesis is one of the most eventful complications in patients with reflux esophagitis (RE). But bleeding is not observed in all patients who have RE with esophageal ulcer. We retrospectively studied the association of bleeding with background factors in patients with RE with esophageal ulcer. Methods Between January 2013 and January 2018, 30 patients were endoscopically diagnosed as RE with Los Angeles classification D (LA-D). These 30 patients were enrolled in our study. Fifteen of them were suddenly admitted to our hospital because the RE exhibited bleeding (B-group). Patients with Mallory-Weiss syndrome, peptic ulcers, and any malignancies were excluded as possible sources of the bleeding. Bleeding was not observed in the remaining 15 RE patients (NB-group). In these 30 patients, we retrospectively studied the relations between the bleeding and the following background factors: age, gender, body mass index (BMI), esophageal hiatal hernia, endoscopical atrophy of the gastric mucosa which is related to the secretion of gastric juice, cognitive decline (so called dementia), diabetes mellitus, and drugs (NSAIDs, PPI). Results The B-group included 5 males and 10 females. The NB-group also included 5 males and 10 females. The mean age of the B-group was 81.7 ± 8.2 (M ± SD) yrs, which was statistically (P < 0.05) greater than that of the NB-group, which was 71.5 ± 11.0 yrs. Older age, larger esophageal hiatal hernia, and cognitive decline (so-called dementia) were significantly (P < 0.05) associated with bleeding on logistic regression analysis. Multiple logistic regression analysis showed that older age and dementia were significantly (P < 0.05) associated with bleeding. Conclusion It is well known that esophageal hiatal hernia is a major factor in erosive RE, such as RE with LA-D. On the other hand, it was speculated that older RE patients and those with cognitive decline could not easily explain their RE complaints, and their condition might be left unattended for long periods. This lack of attention may result in sudden bleeding in patients with non-treated RE. Further studies are needed. Disclosure All authors have declared no conflicts of interest.
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14

Pandey, Deepanjali, Shahid S.Narvi, and Siddhartha Chaudhuri. "Supramolecular Hydrogen Bonded 3D Molecular Self Assembly Constructed from [(Co (nicotinamide)2(thiocyanate)2(H2O)2] Complex Showing Anti-ferromagnetic Character." JOURNAL OF ADVANCES IN CHEMISTRY 10, no. 6 (October 5, 2014): 2864–74. http://dx.doi.org/10.24297/jac.v10i6.6670.

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A new three dimensional hydrogen bonded cobalt frame work from [Co(nicotinamide)2(thiocyanate)2(H2O)2] was synthesized and characterized by X-ray diffraction, magnetism ,TGA and IR spectroscopy. The compound crystallizes in Triclinic space group P-1 with a = 7.5475(19), b = 8.054(2), c =8.932(2). Alpha=73.347(4), beta=70.067(4), gamma=66.559(4) with space group P-1 Z = 1, 'C14 H16 N6 Co O4 S2', Mr =455.38, F(000) = 233 and μ(MoKα) =0.71073 mm-1. The final R = 0.0497 and wR = 0.1461 for 4185 observed reflections with I > 2σ(I) and R = 0.0721 and wR = 0.1619 for all data. X-ray diffraction analyses revealed that Co(1) is linked by the nicotinamide ligands to form the ladder shape along the c axis, which is further extended into two-dimensional networks via the joint of Co(2) along the a axis. Moreover, these two dimensional motifs are interconnected by the thiocyanate S...H bridges to form a complicated 3-D polymeric framework. The magnetic susceptibility data at 1000Oe external field in the temperature range 2-300 K obeys the Curie-Weiss law, giving θ = -24.12 K and C =2.43 thus indicating a dominant strong antiferromagnetic interaction and/or spin orbital coupling between the Co (II) ions.
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Martina, Y., K. T. Marcucci, S. Cherqui, A. Szabo, T. Drysdale, U. Srinivisan, C. A. Wilson, C. Patience, and D. R. Salomon. "Mice Transgenic for a Human Porcine Endogenous Retrovirus Receptor Are Susceptible to Productive Viral Infection." Journal of Virology 80, no. 7 (April 1, 2006): 3135–46. http://dx.doi.org/10.1128/jvi.80.7.3135-3146.2006.

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ABSTRACT Porcine endogenous retrovirus (PERV) is considered one of the major risks in xenotransplantation. No valid animal model has been established to evaluate the risks associated with PERV transmission to human patients by pig tissue xenotransplantation or to study the potential pathogenesis associated with PERV infection. In previous work we isolated two genes encoding functional human PERV receptors and proved that introduction of these into mouse fibroblasts allowed the normally nonpermissive mouse cells to become productively infected (T. A. Ericsson, Y. Takeuchi, C. Templin, G. Quinn, S. F. Farhadian, J. C. Wood, B. A. Oldmixon, K. M. Suling, J. K. Ishii, Y. Kitagawa, T. Miyazawa, D. R. Salomon, R. A. Weiss, and C. Patience, Proc. Natl. Acad. Sci. USA 100:6759-6764, 2003). In the present study we created mice transgenic for human PERV-A receptor 2 (HuPAR-2). After inoculation of transgenic animals with infectious PERV supernatants, viral DNA and RNA were detected at multiple time points, indicating productive replication. This establishes the role of HuPAR-2 in PERV infection in vivo; in addition, these transgenic mice represent a new model for determining the risk of PERV transmission and potential pathogenesis. These mice also create a unique opportunity to study the immune response to PERV infection and test potential therapeutic or preventative modalities.
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Rioux, Michel-Alexandre, Catherine Laurier, Tegwen Gadais, and Miguel Terradas. "Intervenir par le sport auprès de jeunes contrevenants : analyse descriptive et compréhensive de dix interventions." Revue de psychoéducation 46, no. 2 (November 30, 2017): 337–58. http://dx.doi.org/10.7202/1042254ar.

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L’objectif de cette étude est d’analyser des recherches portant sur des interventions fondées sur le sport en milieu de réhabilitation afin de comprendre comment et pourquoi de telles initiatives peuvent avoir un impact sur la réhabilitation des jeunes participants. Une revue de la littérature à été effectuée à partir de quatre bases de données : ERIC, Criminal Justice Abstracts, Psycinfo et Sport Discuss. Toutes les études répondant aux critères d’inclusion (N = 10) ont d’abord été analysées de manière descriptive, puis compréhensive à la lumière de la Théorie du changement (Weiss, 1998). Ces analyses ont permis de mettre en lumière les facteurs associés au fonctionnement des interventions basées sur le sport auprès des jeunes contrevenants. Les grands thèmes sous lesquels se regroupent les principaux facteurs sont (a) les jeunes participants (participation et non participation), (b) l’intervention basée sur le sport (objectifs et mécanismes), (c) l’expérience sportive des participants (entraîneurs et discipline sportive), (d) les effets de l’intervention sur les participants (attitude face à la délinquance, comportements délinquants, physique, psychologique, social et psychoéducative), et finalement, (e) les facteurs influençant la relation entre la participation sportive et les impacts sur les jeunes participants (intra personnels, interpersonnels et programmation). La présente étude mène à des recommandations sur l’implantation d’une intervention basée sur le sport en milieu de réhabilitation.
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Keaney, Michael. "Questionable Interventions: The Enduring Myth of Laissez-Faire." Political Studies Review 15, no. 3 (June 17, 2016): 404–14. http://dx.doi.org/10.1177/1478929916646391.

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The aftermath of the global financial crisis that began in 2007 in the United States and has yet to end has demonstrated the durability of policies and analytical frameworks that have characterised the neoliberal era. Among these has been a strong rhetorical commitment to market-based institutions as synonymous with individual freedom, in contradistinction to the inefficient, bureaucratic state. This has disguised what amounts to a reconfiguration of state power during the last 40 years, such that it is arguably more pervasive than during the preceding Keynesian era. The books under review here each reveal the ideological character of laissez-faire while in various ways hinting at its mythological properties. This mythical aspect is most prominently displayed by Edmund Phelps’ treatment of ‘corporatism’ as responsible for our current ills, when it is in fact integral to contemporary political economy, and cannot be otherwise, absent truly revolutionary change. Cahill D (2014) The End of Laissez-Faire? On the Durability of Embedded Neoliberalism. Cheltenham: Edward Elgar. Phelps E (2013) Mass Flourishing: How Grassroots Innovation Created Jobs, Challenge, and Change. Princeton, NJ: Princeton University Press. Van Apeldoorn B, de Graaff N and Overbeek H (eds) (2014) The State-Capital Nexus in the Global Crisis. London: Routledge. Weiss L (2014) America Inc.? Innovation and Enterprise in the National Security State. Ithaca, NY: Cornell University Press.
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Anisimov, M. A., V. V. Glushkov, S. V. Demishev, N. A. Samarin, N. Y. Shitsevalova, and N. E. Sluchanko. "High Field Magnetoresistance Behavior in PrB6 and NdB6." Solid State Phenomena 152-153 (April 2009): 541–44. http://dx.doi.org/10.4028/www.scientific.net/ssp.152-153.541.

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The comprehensive study of low temperature magnetoresistance (MR) has been carried out on high quality PrB6 and NdB6 single crystals at temperatures 2–20K and in magnetic fields up to 8T. The negative MR (Δρ/ρ<0) was found in the paramagnetic state at T>TN for both compounds. The analysis of the experimental data allows us to establish three contributions to MR. In addition to the main Brillouin type negative component –Δρ/ρ~Mloc2~H2 which may be interpreted in terms of Yosida theory [Phys. Rev. 107 (1957) 396] both the linear and nonlinear magnetic contributions were also deduced. According to detailed analysis in the framework of spin–polaron approach proposed by A.V. Bogach et al. [Physica B 378–380 (1957) 769] the last component should be ascribed to the ferromagnetic (FM) nanodomains embedded in the metallic RB6 matrix. The estimation of local magnetic susceptibility χloc=(–1/H•(d(Δρ/ρ)/dH))1/2 is deduced directly from the quadratic part of negative MR and reveals Curie–Weiss type behaviour in paramagnetic (PM) phase with paramagnetic Curie temperatures Θp~– 22K and –31K for PrB6 and NdB6 correspondingly. The results of undertaken analysis allow to conclude in favour of the concurrence between AF and FM iteractions as the main reason of incommensurate (IC) magnetic structure formation in RB6.
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Bordonskiy, Georgy S., Aleksandr A. Gurulev, Sergey D. Krylov, and Sergey V. Tsyrenzhapov. "Использование микроволновой спектроскопии для изучения состояния переохлажденной воды." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, no. 1 (March 5, 2019): 16–23. http://dx.doi.org/10.17308/kcmf.2019.21/712.

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Представлены методики экспериментов для изучения переохлажденной воды с использованием микроволновой спектроскопии. Одна методика связана с получением глубокого переохлаждения воды в порах силикатного материала, другая основана на получении аморфного состояния в образце пресного льда при его пластической деформации. Показаны возможности методик при изучении свойств переохлажденной воды. При атмосферном давлении и температуре –45 °С (на линии Видома) был определен интервал температур, в котором наблюдаются аномалии микроволновых потерь переохлажденной воды, находящейся в порах силикагеля. При пластической деформации поликристаллического льда наблюдали минимум фактора потерь в микроволновом диапазоне на линии Видома. ЛИТЕРАТУРА Chaplin M. Water Structure and Science. URL: http://www.lsbu.ac.uk/water/chaplin.html (accessed 18 January 2019). Mishima O. Journal of Chemical Physics, 2010, vol. 133, no. 14, p. 144503/6. https://doi.org/10.1063/1.3487999 Xu L., Kumar P., Buldyrev S. V., Chen S.-H., Poole P. H., Sciortino F., Stanley H. E. Proceedings of the National Academy of Sciences of the United States of America, 2005, vol. 102, iss. 46, p. 16558-16562. https://doi.org/10.1073/pnas.0507870102 Franzese G., Stanley Н. E. Journal of Physics Condensed Matter, 2007, vol. 19, p. 205126/1-16. https://doi.org/10.1088/0953-8984/19/20/205126 Sellberg J. A., Huang C., McQueen T. A., Loh N. D., Laksmono H., Schlesinger D., Sierra R. G., Nordlund D., Hampton C. Y., Starodub D., Deponte D. P., Beye M., Chen C., Martin A. V., Barty A., Wikfeldt K. T., Weiss T. M., Caronna C., Feldkamp J., Skinner L. B., Seibert M. M., Messerschmidt M., Williams G. J., Boutet S., Pettersson L. G. M., Bogan M. J., Nilsson A. Nature, 2014, vol. 510, no. 7505, pp. 381-384. https://doi.org/10.1038/nature13266 Bordonskiy G. S., Krylov S. D. Russian Journal of Physical Chemistry A, vol. 86, iss. 11, pp. 1682-1688. https://doi.org/10.1134/S0036024412110064 Bordonskiy G. S., Gurulev A. A., Krylov S. D., Sigachev N. P., Schegrina K. A. Condensed Matter and Interphases, 2016, vol. 18, no. 3, pp. 304-311. https://journals.vsu.ru/kcmf/article/view/138/96 (in Russ.) Castrillón S. R.-V., Giovambattista N., Aksay U. A., Debenedetti P. G. Journal of Physical Chemistry B, 2009, vol. 113, iss. 23, pp. 7973-7976. https://doi.org/10.1021/jp9025392 Cerveny S., Mallamace F., Swenson J., Vogel M., Xu L. Chemical Reviews, 2016, vol. 116, iss. 13, pp. 7608-7625. https://doi.org/10.1021/acs.chemrev.5b00609 Gallo P., Rovere M., Chen S.-H. Journal of Physical Chemistry Letters, 2010, vol. 1, iss. 4, pp. 729-733. https://doi.org/10.1021/jz9003125 Menshikov L. I., Menshikov P. L., Fedichev P. O. Journal of Experimental and Theoretical Physics, vol. 125, iss. 6, pp. 1173-1188. https://doi.org/10.1134/s1063776117120056 Bordonskii G. S., Gurulev A. A., Krylov S. D. Journal of Communications Technology and Electronics, 59, iss. 6, pp. 536-540. https://doi.org/10.1134/s1064226914060060 Bordonskii G. S., Krylov S. D. Technical Physics Letters, vol. 43, iss. 11, pp. 983-986. https://doi.org/10.1134/s1063785017110025 Silonov V. M., Chubarov V. V. Journal of Surface Investigation, 2016, vol. 10, iss. 4, pp. 883-886. DOI: 10.1134/S1027451016030356 Bordonskii G. S., Gurulev A. A. Technical Physics Letters, vol. 43, iss. 4, pp. 380-382. https://doi.org/10.1134/s1063785017040174 Landau L. D., Lifshic E. M. Teoreticheskaya fizika. Tom. 5. Statisticheskaya fizika. CHast' 1. M.: Fizmatlit Publ., 2002, 616 p. (in Russ.). Orlov A. O. Vestnik Zabajkal'skogo gosudarstvennogo universiteta, 2016, vol. 22, no. 8, pp. 14-20. (in Russ.) Nagoe A., Kanke Y., Oguni M., Namba S. Journal of Physical Chemistry B, 2010, vol. 114, iss. 44, pp. 13940-13943. https://doi.org/10.1021/jp104970s Zuev L. B. Fiz. Met., 2015, vol. 16, no. 1, pp. 35–60. (in Russ.).
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Tsai, Jean C., Bruce D. Zelus, Kathryn V. Holmes, and Susan R. Weiss. "The N-Terminal Domain of the Murine Coronavirus Spike Glycoprotein Determines the CEACAM1 Receptor Specificity of the Virus Strain." Journal of Virology 77, no. 2 (January 15, 2003): 841–50. http://dx.doi.org/10.1128/jvi.77.2.841-850.2003.

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ABSTRACT Using isogenic recombinant murine coronaviruses expressing wild-type murine hepatitis virus strain 4 (MHV-4) or MHV-A59 spike glycoproteins or chimeric MHV-4/MHV-A59 spike glycoproteins, we have demonstrated the biological functionality of the N-terminus of the spike, encompassing the receptor binding domain (RBD). We have used two assays, one an in vitro liposome binding assay and the other a tissue culture replication assay. The liposome binding assay shows that interaction of the receptor with spikes on virions at 37°C causes a conformational change that makes the virions hydrophobic so that they bind to liposomes (B. D. Zelus, J. H. Schickli, D. M. Blau, S. R. Weiss, and K. V. Holmes, J. Virol. 77: 830-840, 2003). Recombinant viruses with spikes containing the RBD of either MHV-A59 or MHV-4 readily associated with liposomes at 37°C in the presence of soluble mCEACAM1a, except for S4R, which expresses the entire wild-type MHV-4 spike and associated only inefficiently with liposomes following incubation with soluble mCEACAM1a. In contrast, soluble mCEACAM1b allowed viruses with the MHV-A59 RBD to associate with liposomes more efficiently than did viruses with the MHV-4 RBD. In the second assay, which requires virus entry and replication, all recombinant viruses replicated efficiently in BHK cells expressing mCEACAM1a. In BHK cells expressing mCEACAM1b, only viruses expressing chimeric spikes with the MHV-A59 RBD could replicate, while replication of viruses expressing chimeric spikes with the MHV-4 RBD was undetectable. Despite having the MHV-4 RBD, S4R replicated in BHK cells expressing mCEACAM1b; this is most probably due to spread via CEACAM1 receptor-independent cell-to-cell fusion, an activity displayed only by S4R among the recombinant viruses studied here. These data suggest that the RBD domain and the rest of the spike must coevolve to optimize function in viral entry and spread.
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Rioux, Michel-Alexandre, Catherine Laurier, Tegwen Gadais, and Miguel Terradas. "De l’entraîneur à l’intervenant : réflexion sur l’apport des connaissances issues des sciences du sport aux interventions basées sur le sport auprès des jeunes contrevenants." Revue de psychoéducation 46, no. 2 (November 30, 2017): 313–36. http://dx.doi.org/10.7202/1042253ar.

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L’objectif du présent article est d’initier un dialogue entre les domaines de la psychologie, de la psychoéducation et de la criminologie avec celui des sciences du sport dans le but de synthétiser les récents progrès réalisés en sciences du sport et d’en faire profiter l’intervention basée sur le sport auprès des jeunes contrevenants. Une revue de la littérature a d’abord été effectuée à partir de quatre bases de données : ERIC, Criminal Justice Abstracts, Psycinfo et Sport Discuss. Toutes les études répondant aux critères d’inclusion (n = 8) ont ensuite été analysées de manière descriptive, puis compréhensive à la lumière de la Théorie du changement (Weiss, 1998). Ces analyses ont permis de mettre en lumière les facteurs associés au rôle potentiel de l’entraîneur dans le développement positif des jeunes participants. Ces facteurs concernent le savoir-être et le savoir-faire de l’entraîneur. De plus, cette étude a permis de dégager l’effet que la participation sportive peut avoir sur le bien-être psychologique des jeunes, ainsi que ses conséquences développementales. Finalement des recommandations pratiques concernant la mise en place d’une intervention basée sur le sport en milieu de réhabilitation sont présentées. Ces interventions devraient être dispensées par un intervenant qui : (a) connait bien les besoins des jeunes contrevenants et adapte ses interventions à ceux-ci, (b) possède une philosophie de développement holistique, (c) tend à établir des relations horizontales avec les participants et (d) leur donne une rétroaction positive.
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Bösch, Steffi, Claire Arnauld, and André Jestin. "Study of Full-Length Porcine Endogenous Retrovirus Genomes with Envelope Gene Polymorphism in a Specific-Pathogen-Free Large White Swine Herd." Journal of Virology 74, no. 18 (September 15, 2000): 8575–81. http://dx.doi.org/10.1128/jvi.74.18.8575-8581.2000.

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ABSTRACT Specific-pathogen-free (SPF) swine appear to be the most appropriate candidate for pig to human xenotransplantation. Still, the risk of endogenous retrovirus transmission represents a major obstacle, since two human-tropic porcine endogenous retroviruses (PERVs) had been characterized in vitro (P. Le Tissier, J. P. Stoye, Y. Takeuchi, C. Patience, and R. A. Weiss, Nature 389:681–682, 1997). Here we addressed the question of PERV distribution in a French Large White SPF pig herd in vivo. First, PCR screening for previously described PERV envelope genes envA, envB, and envC(D. E. Akiyoshi, M. Denaro, H. Zhu, J. L. Greenstein, P. Banerjee, and J. A. Fishman, J. Virol. 72:4503–4507, 1998; Le Tissier et al., op. cit.). demonstrated ubiquity of envAand envB sequences, whereas envC genes were absent in some animals. On this basis, selective out-breeding of pigs of remote origin might be a means to reduce proviral load in organ donors. Second, we investigated PERV genome carriage inenvC negative swine. Eleven distinct full-length PERV transcripts were isolated. The sequence of the complete envelope open reading frame was determined. The deduced amino acid sequences revealed the existence of four clones with functional and five clones with defective PERV PK-15 A- and B-like envelope sequences. The occurrence of easily detectable levels of PERV variants in different pig tissues in vivo heightens the need to assess PERV transmission in xenotransplantation animal models.
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Brady, Martin. "The German Epic in the Cold War: Peter Weiss, Uwe Johnson, and Alexander Kluge.By Matthew D. Miller. Evanston IL: Northwestern University Press, 2018. xvi + 237 pages + 10 b/w illustrations. $34.95 paperback or e-book." Monatshefte 112, no. 2 (June 2020): 360–62. http://dx.doi.org/10.3368/m.112.2.360.

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Slaymaker, Olav. "Book Review: Rapid Mass Movement as a Source of Climatic Evidence for the Holocene edited by J. A. Matthews, D. Brunsden, B. Frenzel, B. Gläser and M. M. Weiss, (editors), Gustav Fischer Verlag, Stuttgart, 1997. No. of pages: 444. ISBN 3-437-25388-3." Earth Surface Processes and Landforms 23, no. 6 (June 1998): 576–77. http://dx.doi.org/10.1002/(sici)1096-9837(199806)23:6<576::aid-esp897>3.0.co;2-3.

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Askeland, Frida Bugge, Anne-Marie Rasmussen, and Fredrik Schjesvold. "Relapse from MRD Negativity As Indication for Treatment in Multiple Myeloma - the Remnant Study." Blood 136, Supplement 1 (November 5, 2020): 21–22. http://dx.doi.org/10.1182/blood-2020-139230.

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Background: Early intervention can reduce the rate of progression and improve overall survival (OS) in smouldering multiple myeloma (SMM) patients (pts) (1, 2). The most powerful predictor of prognosis in active MM is whether pts achieve minimal residual disease (MRD) negativity in bone marrow with treatment (3), however treating MRD relapse has not been evaluated in a randomized fashion. The REMNANT study will evaluate whether treating MRD relapse after first line (1.L) treatment prolongs progression free survival (PFS) and OS for MM pts versus treating relapse after 1.L. treatment at progressive disease (PD) (4). To establish a homogenous group of MRD negative pts after 1.L treatment including autologous stem cell transplantation (ASCT), pts are enrolled at diagnosis and treated with Norwegian standard of care (SOC) 1.L treatment. MRD negative pts will move on to the randomized part. Methods: The REMNANT study is an academic, multicenter, open-label, randomized phase II/III study of NDMM pts eligible for ASCT (see Figure 1). 391 pts across Norway will be included in the phase II part of the study and receive SOC 1.L treatment according to Norwegian national guidelines; VRd (V: 1,3 mg/m2 SC Days 1, 4, 8, 11; R: 25 mg PO Days 1-14; d: 20 mg PO Days 1, 2, 4, 5, 8, 9, 11, 12) for 4 pre-transplant induction and 4 post-transplant consolidation cycles (all 21-d cycles). After induction pts will undergo tandem or single ASCT, depending on toxicity and response to first ASCT. The primary endpoint of the phase 2 part of the study is the number of pts who achieve MRD negative (Euroflow NGF 10 -5) complete response (CR) 30-45 days post consolidation. Safety evaluations and pts-reported outcome assessment will be measured. Pts (176) achieving MRD negative CR will be randomly assigned in a 1:1 ratio to receive 2.L treatment at MRD reappearance (arm A) or at progressive disease (PD) as defined by the IMWG criteria (4) (arm B). Randomization will be stratified by R-ISS stage at diagnosis and single vs tandem ASCT. Pts in arm A will be followed with MRD assessment every 4 month and start 2.L treatment at loss of MRD negative CR. Pts in arm B will be followed up by standard criteria and start 2.L treatment at PD. Both arms will receive the same 2.L treatment; KdD (all 28-d cycles) (K: 70mg/m2 iv Days 1,8,15 d: 40 mg Days 1, 8, 15, 22 D: 1800 mg SC Days 1, 8, 15 during C 1-2, Days 1, 8 during cycle 3-6, Day 1 from cycle 7,). 2.L treatment will continue until disease progression, unacceptable AEs or patient withdrawal. In arm A MRD Euroflow will be assessed after 6 and 18 months of 2L therapy. In arm B MRD Euroflow will be assessed if &gt;CR is achieved but not before 6 months of 2 L therapy, and again after 12 consecutive months. The co-primary endpoint is progression and death by any cause (PFS) and death by any cause alone (OS). Secondary endpoints includes TTNT and the proportion pf pts who achieve MRD negative CR during 2.L treatment in arm A and arm B, safety evaluations and pts-reported outcome. The trial is approved and will start enrollment Q3 2020. 1. Mateos MV, Hernandez MT, Giraldo P, de la Rubia J, de Arriba F, Corral LL, et al. Lenalidomide plus dexamethasone versus observation in patients with high-risk smouldering multiple myeloma (QuiRedex): long-term follow-up of a randomised, controlled, phase 3 trial. Lancet Oncol. 2016;17(8):1127-36. 2. Lonial S, Jacobus S, Fonseca R, Weiss M, Kumar S, Orlowski RZ, et al. Randomized trial of lenalidomide versus observation in smoldering multiple myeloma. 2020;38(11):1126-37. 3. Munshi NC, Avet-Loiseau H, Rawstron AC, Owen RG, Child JA, Thakurta A, et al. Association of Minimal Residual Disease With Superior Survival Outcomes in Patients With Multiple Myeloma: A Meta-analysis. JAMA Oncol. 2017;3(1):28-35.5. 4. Kumar S, Paiva B, Anderson KC, Durie B, Landgren O, Moreau P, et al. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol. 2016;17(8):e328-e46. Disclosures Schjesvold: Amgen, Celgene, Janssen, MSD, Novartis, Oncopeptides, Sanofi, SkyliteDX, Takeda: Honoraria; Celgene, Amgen, Janssen, Oncopeptides: Research Funding; Amgen, Celgene, Janssen, MSD, Novartis, Oncopeptides, Sanofi, Takeda: Consultancy. OffLabel Disclosure: Carfilzomib-dexamethason-daratumumab (KdD) as second line treatment
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Sandeman, T. F. "Re: Staging Relationships and Outcome in Early Stage Testicular Cancer: A Report from the Testicular Cancer Intergroup Study, by D. G. McLeod, R. B. Weiss, D. M. Stablein, F. M. Muggia, D. F. Paulson, J. H. Ellis, J. T. Spaulding and J. P. Donohue for the Testicular Cancer Intergroup Study, J. Urol., 145: 1178–1183, 1991." Journal of Urology 148, no. 4 (October 1992): 1267. http://dx.doi.org/10.1016/s0022-5347(17)36887-8.

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Seifert. "M. J. Clarke, J. B. Goodenough, C. K. Jorgense, J. B. Neilands, D. Reinen, R. Weiss, R. J. P. Williams (eds). Complexes, clusters and crystal chemistry. Structure and Bonding, Bd. 79. Springer-Verlag Berlin Heidelberg 1992, 387 S., 268 Abb., 82 Tab., gebunden, ISBN 3-540-55095-X." Crystal Research and Technology 29, no. 1 (1994): 32. http://dx.doi.org/10.1002/crat.2170290109.

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Schneider, P., M. Laßmann, W. Börner, and Johann Link. "Leserbrief zur Arbeit: Erste Ergebnisse der lumbalen Zweienergie-Röntgenabsorptiometrie (DEXA) im Vergleich mit der Doppel-Energie-quantitativen Computertomographie. Von Link, J. M., M. Zwaan, H.-D. Weiss, K. J. Borgis, B. Bätge in: Fortschr. Röntgenstr. 158 (1993) 475-478." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 160, no. 02 (February 1994): 186–87. http://dx.doi.org/10.1055/s-2008-1032403.

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Babu, Suresh. "Book Review : Kevin B. Weiss, A. Sonia Buist, Sean D. Sullivan (eds) Asthma's Impact on Society: The Social and Economic Burden Lung Biology in Health and Disease, vol. 138 Dekker, New York 2000 416 pp.; $125.00 ISBN 0-8247-1942-5." Indoor and Built Environment 8, no. 6 (November 1999): 394. http://dx.doi.org/10.1177/1420326x9900800607.

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Endrika, Sujarwo, and Said Suhil Achmad. "Relationship between Socio-Economic Status, Interpersonal Communication, and School Climate with Parental Involvement in Early Childhood Education." JPUD - Jurnal Pendidikan Usia Dini 14, no. 2 (November 30, 2020): 361–78. http://dx.doi.org/10.21009/jpud.142.14.

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Parental Involvement in their children's schooling has long been recognized as a critical component of good education. This study aims to find out the relationship between socioeconomic status, interpersonal communication, and school climate with parental involvement in early childhood education. Using survey and correlational research design, data collection was carried out through accumulation techniques with tests and questionnaires. The data analysis technique used statistical analysis and multiple regressions. The findings in the socio-economic context of parents show that the measure of power is an indicator in the very high category with a total score of 5, while the measures of wealth, honour and knowledge are included in the high category with a total score of 4 in relation to parental involvement. The form of interpersonal communication, the openness of parents in responding happily to information / news received from schools about children is a finding of a significant relationship with parental involvement in early childhood education. The school climate describes the responsibility for their respective duties and roles, work support provided, and interpersonal communication relationships, parents at home and teachers at school. Keywords: Socio-economic Status, Interpersonal Communication, Climate School, Parental Involvement, Early Childhood Education References Amato, P. R. (2005). The Impact of Family Formation Change on the Cognitive, Social, and Emotional Well-Being of the Next Generation. The Future of Children, 15(2), 75–96. https://doi.org/10.1353/foc.2005.0012 Arnold, D. H., Zeljo, A., Doctoroff, G. L., & Ortiz, C. (2008). Parent Involvement in Preschool: Predictors and the Relation of Involvement to Preliteracy Development. School Psychology Review, 37(1), 74–90. https://doi.org/10.1080/02796015.2008.12087910 Barbato, C. A., Graham, E. E., & Perse, E. M. (1997). Interpersonal communication motives and perceptions of humor among elders. Communication Research Reports, 14(1), 48–57. https://doi.org/10.1080/08824099709388644 Barbato, C. A., Graham, E. E., & Perse, E. M. (2003). Communicating in the Family: An Examination of the Relationship of Family Communication Climate and Interpersonal Communication Motives. Journal of Family Communication, 3(3), 123–148. https://doi.org/10.1207/S15327698JFC0303_01 Barnard, W. M. (2004). Parent involvement in elementary school and educational attainment. Children and Youth Services Review, 26(1), 39–62. https://doi.org/10.1016/j.childyouth.2003.11.002 Benner, A. D., Boyle, A. E., & Sadler, S. (2016). Parental Involvement and Adolescents’ Educational Success: The Roles of Prior Achievement and Socioeconomic Status. Journal of Youth and Adolescence, 45(6), 1053–1064. https://doi.org/10.1007/s10964-016-0431-4 Berkowitz, R., Astor, R. A., Pineda, D., DePedro, K. T., Weiss, E. L., & Benbenishty, R. (2021). Parental Involvement and Perceptions of School Climate in California. Urban Education, 56(3), 393–423. https://doi.org/10.1177/0042085916685764 Berkowitz, R., Moore, H., Astor, R. A., & Benbenishty, R. (2017). A Research Synthesis of the Associations Between Socioeconomic Background, Inequality, School Climate, and Academic Achievement. Review of Educational Research, 87(2), 425–469. https://doi.org/10.3102/0034654316669821 Brand, S., Felner, R. D., Seitsinger, A., Burns, A., & Bolton, N. (2008). A large-scale study of the assessment of the social environment of middle and secondary schools: The validity and utility of teachers’ ratings of school climate, cultural pluralism, and safety problems for understanding school effects and school improvement. Journal of School Psychology, 46(5), 507–535. https://doi.org/10.1016/j.jsp.2007.12.001 Brand, S., Felner, R., Shim, M., Seitsinger, A., & Dumas, T. (2003). Middle school improvement and reform: Development and validation of a school-level assessment of climate, cultural pluralism, and school safety. Journal of Educational Psychology, 95(3), 570–588. https://doi.org/10.1037/0022-0663.95.3.570 Culp, A. M., Hubbs-Tait, L., Culp, R. E., & Starost, H.-J. (2000). Maternal Parenting Characteristics and School Involvement: Predictors of Kindergarten Cognitive Competence Among Head Start Children. Journal of Research in Childhood Education, 15(1), 5–17. https://doi.org/10.1080/02568540009594772 Dearing, E., McCartney, K., Weiss, H. B., Kreider, H., & Simpkins, S. (2004). The promotive effects of family educational involvement for low-income children’s literacy. Journal of School Psychology, 42(6), 445–460. https://doi.org/10.1016/j.jsp.2004.07.002 Desforges, C., Abouchaar, A., Great Britain, & Department for Education and Skills. (2003). The impact of parental involvement, parental support and family education on pupil achievements and adjustment: A literature review. DfES. El Nokali, N. E., Bachman, H. J., & Votruba-Drzal, E. (2010). Parent Involvement and Children’s Academic and Social Development in Elementary School: Parent Involvement, Achievement, and Social Development. Child Development, 81(3), 988–1005. https://doi.org/10.1111/j.1467-8624.2010.01447.x Englund, M. M., Luckner, A. E., Whaley, G. J. L., & Egeland, B. (2004). Children’s Achievement in Early Elementary School: Longitudinal Effects of Parental Involvement, Expectations, and Quality of Assistance. Journal of Educational Psychology, 96(4), 723–730. https://doi.org/10.1037/0022-0663.96.4.723 Epstein, J. L. (Ed.). (2002). School, family, and community partnerships: Your handbook for action (2nd ed). Corwin Press. Fan, X. (2001). Parental Involvement and Students’ Academic Achievement: A Growth Modeling Analysis. The Journal of Experimental Education, 70(1), 27–61. https://doi.org/10.1080/00220970109599497 Fan, X., & Chen, M. (2001). Parental Involvement and Students’ Academic Achievement: A Meta-Analysis. Educational Psychology Review, 23. Georgiou, S. N., & Tourva, A. (2007). Parental attributions and parental involvement. 10. Gorski, P. (2008). The Myth of the Culture of Poverty. Educational Leadership, 65(7), 32–36. Hamre, B. K., & Pianta, R. C. (2005). Can Instructional and Emotional Support in the First-Grade Classroom Make a Difference for Children at Risk of School Failure? Child Development, 76(5), 949–967. https://doi.org/10.1111/j.1467-8624.2005.00889.x Hill, N. E., & Taylor, L. C. (2004). Parental School Involvement and Children’s Academic Achievement: Pragmatics and Issues. Current Directions in Psychological Science, 13(4), 161–164. https://doi.org/10.1111/j.0963-7214.2004.00298.x Hong, S., & Ho, H.-Z. (2005). Direct and Indirect Longitudinal Effects of Parental Involvement on Student Achievement: Second-Order Latent Growth Modeling Across Ethnic Groups. 11. Hornby, G., & Lafaele, R. (2011). Barriers to parental involvement in education: An explanatory model. Educational Review, 63(1), 37–52. https://doi.org/10.1080/00131911.2010.488049 Hoy, W. K., Tarter, C. J., & Hoy, A. W. (2006). Academic Optimism of Schools: A Force for Student Achievement. American Educational Research Journal, 43(3), 425–446. https://doi.org/10.3102/00028312043003425 Jeynes, W.H. (2014). Parent involvement for urban youth and student of color. In Handbook of urban education (In H. R. Milner&K. Lomotey (Eds.)). NY: Routledge. Jeynes, William H. (2005). Effects of Parental Involvement and Family Structure on the Academic Achievement of Adolescents. Marriage & Family Review, 37(3), 99–116. https://doi.org/10.1300/J002v37n03_06 Jeynes, William H. (2007). The Relationship Between Parental Involvement and Urban Secondary School Student Academic Achievement: A Meta-Analysis. Urban Education, 42(1), 82–110. https://doi.org/10.1177/0042085906293818 Kaplan, D. S., Liu, X., & Kaplan, H. B. (2010). Influence of Parents’ Self-Feelings and Expectations on Children’s Academic Performance. 12. Kuperminc, G. P., Leadbeater, B. J., & Blatt, S. J. (2001). School Social Climate and Individual Differences in Vulnerability to Psychopathology among Middle School Students. Journal of School Psychology, 39(2), 141–159. https://doi.org/10.1016/S0022-4405(01)00059-0 Kutsyuruba, B., Klinger, D. A., & Hussain, A. (2015). Relationships among school climate, school safety, and student achievement and well-being: A review of the literature. Review of Education, 3(2), 103–135. https://doi.org/10.1002/rev3.3043 Long, H., & Pang, W. (2016). Family socioeconomic status, parental expectations, and adolescents’ academic achievements: A case of China. Educational Research and Evaluation, 22(5–6), 283–304. https://doi.org/10.1080/13803611.2016.1237369 Loukas, A. (2007). High-quality school climate is advantageous for all students and may be particularly beneficial for at-risk students. 3. Mattingly, D. J., Prislin, R., McKenzie, T. L., Rodriguez, J. L., & Kayzar, B. (2002). Evaluating Evaluations: The Case of Parent Involvement Programs. Review of Educational Research, 72(4), 549–576. https://doi.org/10.3102/00346543072004549 McWayne, C., Hampton, V., Fantuzzo, J., Cohen, H. L., & Sekino, Y. (2004). A multivariate examination of parent involvement and the social and academic competencies of urban kindergarten children. Psychology in the Schools, 41(3), 363–377. https://doi.org/10.1002/pits.10163 Miedel, W. T., & Reynolds, A. J. (1999). Parent Involvement in Early Intervention for Disadvantaged Children: Does It Matter? Journal of School Psychology, 24. N.A., A., S.A., H., A.R., A., L.N., C., & N, O. (2017). Parental Involvement in Learning Environment, Social Interaction, Communication, and Support Towards Children Excellence at School. Journal of Sustainable Development Education and Research, 1(1), 77. https://doi.org/10.17509/jsder.v1i1.6247 Poon, K. (2020). The impact of socioeconomic status on parental factors in promoting academic achievement in Chinese children. International Journal of Educational Development, 75, 102175. https://doi.org/10.1016/j.ijedudev.2020.102175 Porumbu, D., & Necşoi, D. V. (2013). Relationship between Parental Involvement/Attitude and Children’s School Achievements. Procedia - Social and Behavioral Sciences, 76, 706–710. https://doi.org/10.1016/j.sbspro.2013.04.191 Potvin, R. D. P., & Leclerc, D. (1999). Family Characteristics as Predictors of School Achievement: Parental Involvement as a Mediator. MCGILLJOURNAL OF EDUCATION, 34(2), 19. Reynolds, A. J. (1991). 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WEISS, Denise Barros, and Maíra Candian de Paula DUTRA. "ENSINO-APRENDIZAGEM DE PORTUGUÊS COMO LÍNGUA DE HERANÇA: EXPERIÊNCIAS LINGUÍSTICAS, MEMÓRIA FONOLÓGICA E IDENTIDADE CULTURAL." Trama 15, no. 34 (February 27, 2019): 41–51. http://dx.doi.org/10.48075/rt.v15i34.20963.

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A partir de análises que constataram que falantes de Língua de Herança (LH), ao estudarem a língua na fase adulta, produziam elementos fonéticos/fonológicos relacionados à variante da região de origem dos pais, que foram aprendidos na infância, apresentamos nesse artigo repercussões desse resultado de pesquisa para as famílias e para os professores de línguas de herança. Para isso, utilizamos Cummins (1983), com o conceito de LH, Gontijo e Silva (2016) e Souza (2016), que estudam o ensino de LH em diferentes contextos. Também nos baseamos em Izquierdo et al (2013) e Xavier (2013), para compreendermos aspectos da memória humana e em Fonseca, Weiss e Dutra (2018), que observaram os indícios da atuação da memória fonológica no registro da fonética das línguas aprendidas na primeira infância. O aluno de língua de herança tem nessa memória fonológica uma vantagem - uma marca que lhe confere uma identidade cultural, e uma habilidade valorizada na proficiência em L2. REFERÊNCIASBADDELEY, A; ANDERSON, M. C.; EYSENCK, M. W. M. Memória. Tradução de Cornélia Stolting. Porto Alegre: Artmed, 2011.BRITO, K. S. Influências Interlinguísticas na Mente Multilíngue: perspectivas psicolinguísticas e (psico)tipológicas. Tese (Doutorado em Letras - Estudos Linguísticos) - Setor de Ciências Humanas, Letras e Artes, Universidade Federal do Paraná. Curitiba, 2011. 274 p. Disponível em: https://acervodigital.ufpr.br/bitstream/handle/1884/27123/R%20-%20T%20-%20KARIM%20SIEBENEICHER%20BRITO.pdf?sequence=1isAllowed=y. Acesso em: 14 fev. 2019.CUMMINS, J. Heritage Language Education: a literature review. Ontario Inst. for Studies in Education, Ontario Dept. of Education: Toronto, 1983. 64 p.DALMAZ, C..; NETTO, C. A. A memória. Cien. Cult. São Paulo, v. 56, n. 1, p. 30-31, jan./mar. 2004. Disponível em: http://cienciaecultura.bvs.br/scielo.php?script=sci_arttextpid=S0009-67252004000100023lng=ennrm=iso. Acesso em: 28 out. 2018.DOI, E. T. O ensino de japonês no Brasil como língua de imigração. Estudos Lingüísticos. XXXV. Campinas, 2006. p. 66-75.FLORES, C.; MELO-PFEIFER, S. O conceito “Língua de Herança” na perspectiva da Linguística e da Didática de Línguas: considerações pluridisciplinares em torno do perfil linguístico das crianças luso descendentes na Alemanha. Revista Domínios de Lingu@gem. São Paulo, v. 8, n. 3, p. 16-45, 2014. Disponível em: http://www.seer.ufu.br/index.php/dominiosdelinguagem/article/view/24736/15191. Acesso em: 17 ago. 2018.FONSECA, A. A.; WEISS, D. B.; DUTRA, M. C. P. Memória fonológica de falantes de português brasileiro como língua de herança. Revista Domínios de Lingu@gem. São Paulo, v. 12, n. 2, p. 1267-1293, 2018. Disponível em: http://www.seer.ufu.br/index.php/dominiosdelinguagem/article/view/40099/22388. Acesso em: 28 ago. 2018.GONTIJO, V.; SILVA, G. V. A ansiedade no aprendizado de Português como Língua Estrangeira e Português como Língua de Herança. In: SILVA, K. A.; SANTOS, D. T. (Orgs.) Português como Língua (Inter)Nacional: faces e interfaces. Campinas: Pontes, 2016. p. 47 – 67.IZQUIERDO, I. et al. Memória: tipos de mecanismos - achados recentes. Revista USP. São Paulo, n. 98, p. 10-16, jun./ jul./ ago. 2013. Disponível em http://www.revistas.usp.br/revusp/article/view/69221/71685. Acesso em 17 ago. 2018.JASINSKA, K. K. et al. Bilingualism yields language-specific plasticity in left hemisphere's circuitry for learning to read in young children. Neuropsychologia. USA, v. 98, p.24-45, 2017.KLEIN, D. et al. Age of language learning shapes brain structure: a cortical thickness study of bilingual and monolingual individuals. Brain and Language. USA, v. 131, p. 20–24, 2014.LICO, A. L. C. Ensino do Português como Língua de Herança: Prática e Fundamentos. Revista SIPLE. Brasília, n.1, ano 2, 2011. Não paginado. Disponível em: http://www.siple.org.br/index.php?option=com_contentview=articleid=177:2-ensino-do-portugues-como-lingua-de-heranca-pratica-efundamentoscatid=57:edicao-2Itemid=92. Acesso em: 17 ago. 2018.MONARETTO, V. N. O.; QUEDNAU, L. R.; HORA, D. As consoantes do Português. In: BISOL, L. (Org.) Introdução a estudos de fonologia do português brasileiro. 3a Ed. Porto Alegre: EDIPUCRS, 2001. p. 195-228.NORTON, B. Identity and language learning: gender, ethnicity and educational change. Londres: Longman, 2000.OLIVEIRA, K. C. S.; LEITE, M. A.; SILVA, P. C. D. Memória. Cadernos CESPUC. Belo Horizonte, n. 23. p. 19-29, 2013.SOLÉ, Y. Consideraciones pedagógicas en la enseñanza del español a estudiantes bilingues. In: VALDÉS, G.; LOZANO, A.; GARCÍA-MOYA, R, (Orgs.) Teaching Spanish to Hispanic bilingual: issues, aims, and methods. New York: Teachers College Press, 1981. p. 21-29SOUZA, A.; BARRADAS, O. Português como língua de herança: políticas linguísticas na Inglaterra. Revista SIPLE. Brasília, n. 1, ano 4, 2013. Não paginado. Disponível em: http://www.siple.org.br/index.php?option=com_contentview=articleid=297:portugues-como-lingua-de-heranca-politicas-linguisticas-na-inglaterracatid=69:edicao-6Itemid=112. Acesso em: 28 ago. 2018.SOUZA, A. Como as identidades linguística e cultural são influenciadas pela imigração. In: SOUZA, A. (Org.). Português como Língua de Herança em Londres: recortes em casa, na igreja e na escola. Campinas: Pontes, 2016. p. 21-30.SOUZA, A. Maternidade e imigração: um foco no planejamento linguístico familiar. In: SOUZA, A. (Org.). Português como Língua de Herança em Londres: recortes em casa, na igreja e na escola. Campinas: Pontes, 2016. p. 11-51.XAVIER, G. F. Memória, individualidade e inconsciente como expressões do funcionamento de redes nervosas: uma breve especulação. Revista USP. São Paulo, n.98, p. 31-40, jun./ jul./ ago. 2013. Disponível em: https://www.revistas.usp.br/revusp/article/view/69223/71687. Acesso em: 28 out. 2018.XAVIER, G. F. A Modularidade da Memória e o Sistema Nervoso. Psicologia USP. São Paulo, v.4, n.1-2, p. 61-115, 1993. Disponível em: http://www.revistas.usp.br/psicousp/article/view/34473 . Acesso em 28 out. 2018. Recebido em 31-10-2018.Aceito em 18-02-2018.
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CSCI, _. "CSCI Young Investigators Forum Abstracts." Clinical & Investigative Medicine 32, no. 4 (August 1, 2009): 1. http://dx.doi.org/10.25011/cim.v32i4.6623.

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ASSESSMENT OF PARALLEL SIGNALING PATHWAYS IN UTERINE MYOCYTES STIMULATED WITH VARIOUS SMOOTH MUSCLE AGONISTS H.N. Aguilar, B.F. Mitchell 1 TRACTOGRAPHY: A NOVEL TECHNIQUE TO IMAGE FIBER TRACTS OF THE SPINAL CORD Fahad Alkherayf, Eve Tsai, Arturo Cardenas-Blanco, Alain Berthiaume, Brien Benoit, John Sinclair 1 MODULATION OF OSTEOCLASTOGENESIS IN INFLAMMATORY JOINT DISEASES H. Allard-Chamard, M. Durant, A.J. de Brum-Fernandes, G. Boire, S.V. Komarova, S.J. Dixon, S.M. Sims, R. Harison, M.F. Manolson 2 “THE RIGHT THING TO DO? A CRITICAL ANALYSIS OF PUBLIC HEALTH ETHICS, RIGHTS DISCOURSE, AND THE EXPANSION OF ANTIRETROVIRAL THERAPY (ART)” Berkhout, SG, Anderson, S, Tyndall, MW 2 COST-EFFECTIVENESS OF IMMEDIATE BASELINE COMPUTED TOMOGRAPHY VS. MAGNETIC RESONANCE IMAGING OF ACUTE ISCHEMIC STROKE IN ONTARIO PATIENTS WHO PRESENT WITH SYMPTOMS SUGGESTIVE OF STROKE KR Burton, G. Mery 3 CHITOSAN-MEDIATED FGF18 DELIVERY FOR ASSISTED BONE REPAIR A. Carli, M. Lavertu, C. Gao, A. Merzouki, M.D. Buschmann, J.E. Henderson, E.J.Harvey 3 ACTIVE PI3K-AKT SIGNALING PROMOTES THE METASTATIC POTENTIAL OF ASCITES-DERIVED EPITHELIAL OVARIAN CANCER CELLS Correa RJM, Ramos-Valdes Y, Bertrand M, Lanvin D, Préfontaine M, Sugimoto AK, Lewis JD, Shepherd TG, DiMattia GE 4 MECHANISMS OF K65R, D67N, K103N, V106M AND M184V RESISTANCE DEVELOPMENT IN SUBTYPE-B AND C HIV-1 Dimitrios Coutsinos, Cedric F. Invernizzi, Daniela Moisi, Maureen Oliveira, Hongtao Xu, Bluma G. Brenner, Mark A. Wainberg 4 A MODEL TO DETERMINE FACTORS INVOLVED IN THE INDUCTION OF AN IN VIVO CTL RESPONSE Dissanayake D, Ohashi PS 5 P63 ANTAGONIZES P53 TO PROMOTE THE SURVIVAL OF EMBRYONIC NEURAL PRECURSOR CELLS Sagar B. Dugani, Annie Paquin, Masashi Fujitani, David R. Kaplan, Freda D. Miller 5 SPINAL LOCOMOTOR NETWORK MODULATION BY ENDOGENOUS SEROTONIN IN THE ISOLATED NEONATAL MOUSE SPINAL CORD Dunbar MJ, Whelan PJ 6 THE TUMOR PROMOTING AND REPRESSING EFFECTS OF INTEGRIN-LINKED KINASE ARE DIFFERENTIATED BY JNK1 IN HUMAN CANCER CELLS Adam David Durbin, Gregory Edward Hannigan, David Malkin 6 INCREASED EXCITATION IN MICE OVER-EXPRESSING NEUROLIGIN-1 IS ASSOCIATED WITH IMPAIRED LONG-TERM POTENTIATION AND LEARNING AND MEMORY Brennan D Eadie, Timal Kannangara, Regina Dalhaus, Rochelle M Hines, Yu-Tian Wang, Alaa El-Husseini, Brian R Christie 7 A NOVEL ROLE FOR CDK5/P35 IN MEDULLOBLASTOMA FORMATION Friesen AN, Shin J, Law V, Lee YS, Mckinnon P, Lee KY 7 ALTERED PSYCHOSOCIAL BEHAVIOUR AND STRESS RESPONSE FOLLOWING ‘MINOR’ STROKE IN THE RAT Krista Hewlett, Meighan Kelly, Dale Corbett 8 TUMOUR PATHOLOGY PREDICTS MICROSATELLITE INSTABILITY IN COLORECTAL CANCER AJ Hyde, D Fontaine, S Stuckless, RC Green, A Pollett, M Simms, P Parfrey, HB Younghusband 8 PROTEINASE-ACTIVATED RECEPTOR-2 (PAR2) IS A POTENTIAL TARGET FOR THE ANTI-INFLAMMATORY EFFECTS OF INSULIN Eric Hyun, Rithwick Ramachandran, Nicolas Cenac, Steeve Houle, Amit Saxena, Roland S. Liblau, Morley Hollenberg, Nathalie Vergnolle 9 CHEMOSENSITIVE PROPERTIES OF THE VENTRAL MEDULLA IN VITRO Kalf Daniel J, Wilson Richard JA 9 NOVEL DOPAMINE RECEPTOR-N TYPE CALCIUM CHANNEL INTERACTIONS: POTENTIAL THERAPEUTIC TARGETS FOR DISORDERS ASSOCIATED WITH ABERRANT DOPAMINERGIC SIGNALLING Alexandra E. Kisilevsky, Sean J. Mulligan, Christophe Altier, Mircea C. Iftinca, Diego Varela, Chao Tai, Lina Chen, Shahid Hameed, Jawed Hamid, Brian A. MacVicar, Gerald W. Zamponi 10 TRUNCATION OF THE C-TERMINAL DOMAIN OF CONNEXIN43 INCREASES INFARCT VOLUME DURING STROKE Kozoriz MG, Bechberger JF, Bechberger GR, Suen MWH, Moreno AP, Maass K, Willecke K, Naus CC 10 EVALUATION OF THE DELIVERABILITY AND TOLERABILITY OF INTENSIVE WEEKLY DOUBLET ADJUVANT CHEMOTHERAPY IN NON SMALL CELL LUNG CANCER M. Sara Kuruvilla, Lorraine Martelli-Reid, J. R. Goffin, A. Arnold, Peter M. Ellis 11 A POLICY-ORIENTED SYSTEMATIC REVIEW OF THE SAFETY AND EFFICACY OF ENDOSCOPIC THERAPIES FOR THE TREATMENT OF BARRETT’S ESOPHAGUS Lau D, Menon D, Stafinski T, Topfer LA, Walker J 11 THE SRC-LIKE ADAPTOR PROTEIN, SLAP, PLAYS A ROLE IN MONOCYTE-DERIVED DENDRITIC CELL MATURATION Larissa Liontos, L Dragone, A Weiss, C J McGlade 12 SWEET PEE: A NEW MOUSE MODEL FOR GLOMERULOCYSTIC KIDNEY DISEASE AND GLUCOSURIA J Ly, J Rossant, L Oxborne, C McKerlie, A Flenniken, S Quaggin 12 CARDIOGENIC SHOCK IN ASPHYXIATED NEONATE PIGLETS: IS COMBINATION INOTROPE THERAPY BETTER THAN HIGH-DOSE DOPAMINE? N. Manouchehri, P.-Y. Cheung, C. Joynt, T. Churchill, D. Bigam 13 THE RELATIONSHIP BETWEEN FLOW-MEDIATED DILATION, HYPEREMIC SHEAR STRESS, AND VARIOUS ANTHROPOMETRIC INDICES OF OBESITY Martin BJ, Title LM, Verma S, Charbonneau F, Buithieu J, Lonn EM, Anderson TJ 13 RAPID LOCALIZATION OF NEUTROPHILS TO SITES OF CELL DEATH BY MAC1-DEPENDENT ADHESION AND INTRAVASCULAR CRAWLING McDonald B, Menezes GB, Kubes P 14 THE ROLE OF SHIP-1 IN CEACAM1-MEDIATED HOST RESPONSES TO NEISSERIA GONORRHOEAE INFECTION Gordon G McSheffrey, S D Gray-Owen 14 USING VOLTAGE-SENSITIVE DYES TO RECORD BRAIN ACTIVITY IN NATURALLY MOVING MICE McVea DA, Mohajerani MH, Fingas M, Murphy TH 15 POTENTIAL MECHANICAL INFLUENCE IN MICROVASCULAR PATHOLOGY IN THE ACL DEFICIENT RABBIT KNEE Daniel Miller 15 OSTEOBLAST MECHANOSENSITIVITY: THE ROLE OF HYDROSTATIC PRESSURE Kenneth A. Myers, Timothy Douglas, Ricarda Hess, Justin Parreno, Jerome B. Rattner, Dieter Scharnweber, Nigel G. Shrive, David A. Hart 16 ENDOTHELIAL PROGENITOR CELLS FOR HEALING AND ANGIOGENESIS IN A SEGMENTAL BONE DEFECT MODEL: A COMPARISON WITH MESENCHYMAL STEM CELLS Nauth A, Li R, Schemitsch EH 16 DELAY OF DNA METHYLATION IN PERINATAL MALE GERM CELLS IN THE ABSENCE OF DNMT3L RESULTING IN INFERTILITY Kirsten Niles, Sophie La Salle, Christopher Oakes, Jacquetta Trasler 17 INVESTIGATING CRMP4 FUNCTION IN CNS NERVE REGENERATION S. Ong Tone, S. Kanagal, A. Wilson, Y.Z. Alabed, A. Di Polo, A.E. Fournier 17 A NOVEL, DNA DAMAGE-DEPENDENT REGULATORY PATHWAY FOR AKT IN VIVO Andrew J. Perrin, W. Brent Derry 18 CHOP AS A TARGET FOR PRESERVATION OF TRANSPLANTED ISLET GRAFT MASS Potter K, Dai L, Verchere CB 18 TREATMENT OF ACHILLES TENDINOPATHY R Ram, C Patel, D Wiseman, W Meeuwisse, JP Wiley 19 PLACENTAL LACTOGEN FUNCTION IN POST-IMPLANTATION MURINE PREGNANCY Saara M. Rawn, James C. Cross 19 DECODING NEURAL SIGNALS FROM MULTIELECTRODE ARRAYS IN THE PRIMATE DORSOLATERAL PREFRONTAL CORTEX Sachs A.J, Pieper F, Martinez-Trujillo J.C. 20 THE ROLE OF TRANSFORMING GROWTH FACTOR ALPHA IN A MOUSE MODEL OF OSTEOARTHRITIS Usmani S.E, Appleton C.T.G., Welch I.D, Beier F. 20 SKIN-DERIVED STEM CELLS ACT AS FUNCTIONAL SCHWANN CELLS WHEN TRANSPLANTED INTO LESIONED PERIPHERAL NERVE Sarah K. Walsh, Rajiv Midha 21 TLR4 MEDIATES SUSCEPTIBILITY TO STREPTOZOTOCIN-INDUCED DIABETES C Westwell-Roper, G Soukhatcheva, MJH Hutton, JP Dutz, CB Verchere 21 A FUSION OF GMCSF AND IL-21 (GIFT-21) POTENTLY INDUCES INFLAMMATION AND APOPTOSIS THROUGH SIGNALS DOWNSTREAM OF THE IL-21R ALPHA CHAIN Patrick Williams, Shala Yuan, Jessica Cuerquis, Elena Birman, Kathy Ann Forner, Jacques Galipeau 22
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Webber, Beau, Matthew Johnson, Nicholas Slipek, Walker Lahr, Xiaohong Qiu, Blaine Rathmann, Miechaleen Diers, Bryce Wick, R. Scott McIvor, and Branden Moriarity. "35 Targeted non-viral integration of large cargo in primary human T cells by CRISPR/Cas9 guided homology mediated end joining." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A36. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0035.

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BackgroundEngineered immune cells hold tremendous promise for the treatment of advanced cancers. As the scale and complexity of engineered cell therapies increase, reliance on viral vectors for clinical production limits translation of promising new therapies. Here, we present an optimized platform for CRISPR/Cas9-targeted, non-viral engineering of primary human T cells that overcomes key limitations of previous approaches, namely DNA-induced toxicity and low efficiency integration of large genetic cargos.MethodsA systematic optimization of nucleic acid delivery, editing reagent composition, and culture protocol was performed to overcome DNA toxicity. Targeted knockin (KI) at AAVS1 and TRAC was compared across multiple vector configurations with genetic cargos ranging from 1 to 3 kilobases (kb) in size. Integration efficiency was measured by flow cytometry and sequencing. Off-target editing and integration were evaluated using GUIDE-seq and targeted locus amplification (TLA), respectively. Phenotype and function of non-virally and lentivirus engineered CAR-T cells was compared using flow cytometry, cytokine profiling and cytotoxicity assays.ResultsWe identified a temporal window following T cell activation where transfection efficiency, cell-cycle-status, and cytosolic DNA sensor expression were optimal for targeted DNA integration and reduced toxicity. Within this window, we targeted a 1kb GFP reporter to the AAVS1 locus with an efficiency of ~45% using homologous recombination (HR). Efficiency was reduced to ~11% with a larger ~3kb TCR cassette targeted to the TRAC locus, consistent with previous reports.1–3 To improve large cargo integration we employed homology mediated end-joining (HMEJ) and short homology design (48bp vs. ~1kb for traditional HR).4 Using HMEJ, knockin of the 1kb GFP cassette at AAVS1 reached ~70%. Strikingly, integration of the 3kb TCR at TRAC reached ~50% using HMEJ. Additional optimization of the culture protocol doubled post-engineering survival and proliferation (up to ~35-fold expansion in 7 days). Non-virally engineered TRAC KI CAR-T cells were phenotypically and functionally equivalent to lentivirally engineered T cells in vitro. In vivo assays in xenograft models are underway and results will be presented.ConclusionsComprehensive, orthogonal optimization of parameters impacting nucleic acid delivery and DNA-toxicity in combination with novel modalities for integration achieved knockin of TCR and CAR cargo at efficiencies equivalent to that of current viral vector platforms without compromising expansion or function. Our protocol is suitable for clinical scale production under GMP conditions and offers an improved methodology over previous methods for non-viral engineering of human T cells.ReferencesRoth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel J-N, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros M, Gurumurthy CB, Smith, B, Haugwitz M, Hughes SH, Weissman JS, Schumann K., Esensten JH., May AP, Ashworth A., Kupfer G. M., Atma S., Greeley W. & Marson A. Reprogramming human T cell function and specificity with non-viral genome targeting. Naturedoi:10.1038/s41586-018-0326-5Parker Autoimmune SN, Zuckerberg Biohub C, Francisco S. & Helen U. Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nat. Biotechnol. doi:10.1038/s41587-019-0325-6Schober K, Müller TR, Gökmen F, Grassmann S, Effenberger M, Poltorak M, Stemberger C, Schumann K, Roth TL, Marson A. & Busch DH. Orthotopic replacement of T-cell receptor α- and β-chains with preservation of near-physiological T-cell function. Nature Biomedical Engineering 3, 974–984 ( 2019).Wierson WA, Welker JM, Almeida MP, Mann CM, Webster DA, Torrie ME, Weiss TJ, Kambakam S, Vollbrecht MK, Lan M, McKeighan KC, Levey J, Ming Z, Wehmeier A, Mikelson CS, Haltom JA, Kwan KM, Chien C-B, Balciunas D, Ekker SC, Clark KJ, Webber, BR, Moriarity BS, Solin SL, Carlson DF, Dobbs DL, McGrail M & Essner J. Efficient targeted integration directed by short homology in zebrafish and mammalian cells. Elife9, ( 2020).
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Jaremko, J. L., B. Felfeliyan, A. Rakkunedeth, B. Thejeel, V. Quinn-Laurin, M. Østergaard, P. G. Conaghan, R. Lambert, J. Ronsky, and W. P. Maksymowych. "AB0594 IMPROVING OSTEOARTHRITIS CARE BY AUTOMATIC MEASUREMENT OF HIP EFFUSION USING AI." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1334.1–1334. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2196.

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Background:Osteoarthritis (OA) is the commonest disease affecting hip joints and has high prevalence across various age groups [1,2]. Effusion is a hallmark of OA and could represent a potential target for therapy [3–5]. Positive correlations of effusion to clinical outcomes are not well established, partly due to variability in manual assessment. Voxel-based volume quantification could reduce this variability [6].Objectives:We examine the inter-observer agreement of manual assessment of voxel-based effusion volume from coronal STIR MRI sequences at two time points and examine the feasibility of using Artificial Intelligence (AI) for standalone volume assessment.Methods:Our algorithm is based on Mask R-CNN [7] and was trained on labeled effusion regions in MRI slices from 68 patients with hip osteoarthritis. For validation, 2 human readers measured effusion from MRI STIR sequences of 25 patients at baseline and at 8 weeks follow-up. AI was used to measure effusion volume as an independent reader. Agreement between human readers and AI was assessed using absolute difference in volume (DV), Coefficients of Variation (CoV) and intraclass correlation coefficient (ICC).Results:Effusion regions detected by AI closely correlated with manual segmentation (Figure 1) for all samples. Differences in volumes measured by each pair of readers are summarized in Table 1. Agreement was excellent between human readers (ICC=0.99) and for each reader vs AI (ICC = 0.85-0.87).Figure 1.Mask overlays of regions of joint fluid detected by human readers (green, column 2) and AI (red, column 3) from 3 different patients. Raw MRI images are shown in column 1.Table 1.Comparison of volumes measured in cubic millimeters and agreement between each pair of readers (with AI as the 3rd reader)Volumes measured by readersAgreement between reader pairsReaderOverall VolumeMean ± Standard DeviationReader PairDifference in VolumeMean ± Standard DeviationCoVICCReader 16943 ± 5845Reader 1-21127 ± 9000.210.99 [0.98, 1.0]Reader 27638 ± 5619Reader 1-AI3311 ±16430.350.87 [0.7, 0.94]AI11014 ± 4454Reader 2-AI4151 ± 49860.270.85 [0.66,0.94]Conclusion:Initial results of automatic effusion measurement using AI show high agreement with human experts. This has potential to reduce variability and save expert time in OA MRI assessment, and to lead to improved OA care.References:[1]Sharif B, Garner R, Hennessy D, Sanmartin C, Flanagan WM, Marshall DA. Productivity costs of work loss associated with osteoarthritis in Canada from 2010 to 2031. Osteoarthritis Cartilage. 2017 Feb;25(2):249–58.[2]Sharif B, Kopec J, Bansback N, Rahman MM, Flanagan WM, Wong H, et al. Projecting the direct cost burden of osteoarthritis in Canada using a microsimulation model. Osteoarthritis Cartilage. 2015 Oct;23(10):1654–63.[3]Loeuille D, Chary-Valckenaere I, Champigneulle J, Rat A-C, Toussaint F, Pinzano-Watrin A, et al. Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity. Arthritis Rheum. 2005 Nov;52(11):3492–501.[4]Fernandez-Madrid F, Karvonen RL, Teitge RA, Miller PR, An T, Negendank WG. Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis. Magn Reson Imaging. 1995;13(2):177–83.[5]Atukorala I, Kwoh CK, Guermazi A, Roemer FW, Boudreau RM, Hannon MJ, et al. Synovitis in knee osteoarthritis: a precursor of disease? Ann Rheum Dis. 2016 Feb;75(2):390–5.[6]Quinn-Laurin V, Thejeel B, Chauvin NA, Brandon TG, Weiss PF, Jaremko JL. Normal hip joint fluid volumes in healthy children of different ages, based on MRI volumetric quantitative measurement. Pediatr Radiol. 2020 Oct;50(11):1587–93.[7]He K, Gkioxari G, Dollár P, Girshick R. Mask r-cnn. In: Proceedings of the IEEE international conference on computer vision. openaccess.thecvf.com; 2017. p. 2961–9.Acknowledgements:Jacob Jaremko is supported by the AHS Chair in Diagnostic Imaging at the University of Alberta. Medical Imaging Consultants (MIC) funds musculoskeletal radiology fellowships for Vanessa Quinn-Laurin at the University of Alberta, and provides Jacob Jaremko and Robert Lambert with protected academic time. Banafshe Felfeliyan is supported by an Alberta Innovates Graduate Student Scholarship for Data-Enabled Innovation.Disclosure of Interests:None declared.
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Fassnacht, Martin, Olaf M. Dekkers, Tobias Else, Eric Baudin, Alfredo Berruti, Ronald R. de Krijger, Harm R. Haak, Radu Mihai, Guillaume Assie, and Massimo Terzolo. "European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors." European Journal of Endocrinology 179, no. 4 (October 2018): G1—G46. http://dx.doi.org/10.1530/eje-18-0608.

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Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone-producing tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with best possible evidence-based recommendations for clinical management of patients with ACC based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. We predefined four main clinical questions, which we judged as particularly important for the management of ACC patients and performed systematic literature searches: (A) What is needed to diagnose an ACC by histopathology? (B) Which are the best prognostic markers in ACC? (C) Is adjuvant therapy able to prevent recurrent disease or reduce mortality after radical resection? (D) What is the best treatment option for macroscopically incompletely resected, recurrent or metastatic disease? Other relevant questions were discussed within the group. Selected Recommendations: (i) We recommend that all patients with suspected and proven ACC are discussed in a multidisciplinary expert team meeting. (ii) We recommend that every patient with (suspected) ACC should undergo careful clinical assessment, detailed endocrine work-up to identify autonomous hormone excess and adrenal-focused imaging. (iii) We recommend that adrenal surgery for (suspected) ACC should be performed only by surgeons experienced in adrenal and oncological surgery aiming at a completeen blocresection (including resection of oligo-metastatic disease). (iv) We suggest that all suspected ACC should be reviewed by an expert adrenal pathologist using the Weiss score and providing Ki67 index. (v) We suggest adjuvant mitotane treatment in patients after radical surgery that have a perceived high risk of recurrence (ENSAT stage III, or R1 resection, or Ki67 >10%). (vi) For advanced ACC not amenable to complete surgical resection, local therapeutic measures (e.g. radiation therapy, radiofrequency ablation, chemoembolization) are of particular value. However, we suggest against the routine use of adrenal surgery in case of widespread metastatic disease. In these patients, we recommend either mitotane monotherapy or mitotane, etoposide, doxorubicin and cisplatin depending on prognostic parameters. In selected patients with a good response, surgery may be subsequently considered. (vii) In patients with recurrent disease and a disease-free interval of at least 12 months, in whom a complete resection/ablation seems feasible, we recommend surgery or alternatively other local therapies. Furthermore, we offer detailed recommendations about the management of mitotane treatment and other supportive therapies. Finally, we suggest directions for future research.
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Hammed, Mohammed Majeed, Mohamed Khalid AlOmar, Faidhalrahman Khaleel, and Nadhir Al-Ansari. "An Extra Tree Regression Model for Discharge Coefficient Prediction: Novel, Practical Applications in the Hydraulic Sector and Future Research Directions." Mathematical Problems in Engineering 2021 (September 21, 2021): 1–19. http://dx.doi.org/10.1155/2021/7001710.

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Despite modern advances used to estimate the discharge coefficient ( C d ), it is still a major challenge for hydraulic engineers to accurately determine C d for side weirs. In this study, extra tree regression (ETR) was used to predict the C d of rectangular sharp-crested side weirs depending on hydraulic and geometrical parameters. The prediction capacity of the ETR model was validated with two predictive models, namely, extreme learning machine (ELM) and random forest (RF). The quantitative assessment revealed that the ETR model achieved the highest accuracy in the predictions compared to other applied models, and also, it exhibited excellent agreement between measured and predicted C d (correlation coefficient is 0.9603). Moreover, the ETR achieved 6.73% and 22.96% higher prediction accuracy in terms of root mean square error in comparison to ELM and RF, respectively. Furthermore, the performed sensitivity analysis shows that the geometrical parameter such as b/B has the most influence on C d . Overall, the proposed model (ETR) is found to be a suitable, practical, and qualified computer-aid technology for C d modeling that may contribute to enhance the basic knowledge of hydraulic considerations.
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Seidler, Andreas, Sabine Jähnichen, Janice Hegewald, Alba Fishta, Olga Krug, Luisa Rüter, Claudia Strik, Ernst Hallier, and Sebastian Straube. "Reply to: Pesch B, Weiss T, Pallapies D, Schlüter G, Brüning T. Letter to the editor. Re: Seidler A, Jähnichen S, Hegewald J, Fishta A, Krug O, Rüter L, Strik C, Hallier E, Straube S. Systematic review and quantification of respiratory cancer risk for occupational exposure to hexavalent chromium." International Archives of Occupational and Environmental Health 86, no. 8 (May 28, 2013): 961–63. http://dx.doi.org/10.1007/s00420-013-0888-3.

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Bordonsky, Georgy S., and Alexander A. Gurulev. "О физико-химических превращениях с участием воды вблизи температуры –45 °C." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, no. 4 (December 19, 2019): 478–89. http://dx.doi.org/10.17308/kcmf.2019.21/2359.

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Представлена гипотеза о новом механизме ускорения химических реакцийс участием переохлажденной воды вблизи –45 °C. Гипотеза основана на свойствах второйкритической точки воды. Предполагается, что возрастание флуктуации энергии молекулводы приводит к ускорению протекания химических превращений. В эксперименте сиспользованием нанопористых увлажненных силикатных сорбентов удалось наблюдатьреакцию взаимодействия водорода с поверхностью пор при –45 °C. Химические реакциис участием воды по предполагаемому механизму могут ускоренно протекать на линииВидома при температурах от –45 °C до –53 °C и в области давлений от 0 до 100 MPa. ЛИТЕРАТУРА1. Palmer M. Y., Cordiner M. A., Nixon C. A., Charnley S. B., Teanby N. A., Kisiel, Z., Irwin P. G. J., MummaM. J. ALMA detection and astrobiological potential of vinyl cyanide on Titan // Science Advances, 2017,v. 3(7), p. e1700022/6. DOI: https://doi.org/10.1126/sciadv.17000222. Goesmann F., Rosenbauer H., Bredehöft J. H., Cabane M., Ehrenfreund P., Gautier T., Giri C.,Kröger H., Le Roy L., MacDermott A.J., McKenna-Lawlor S., Meierhenrich U.J., Caro G.M.M., Raulin F.,Roll R., Steele A., Steininger H., Sternberg R., Szopa C., Thiemann W., Ulamec S. Organic compounds on comet67P/Churyumov–Gerasimenko revealed by COSAC mass spectrometry // Science, 2015, v. 349(6247),p. aab0689-1/3. DOI: https://doi.org/10.1126/science.aab06893. Mumma M. J., Villanueva G. L., Novak R. E., Hewagama T., Bonev B. P., DiSanti M. A., Mandell A. M.,Smith M. D. Strong release of methane on Mars in northern summer 2003 // Science, 2009, v. 323(5917),pp. 1041–1045. DOI: https://doi.org/10.1126/science.1165243.4. Кораблев О. И. Исследования атмосфер планет земной группы // Успехи физических наук, 2005,т. 175(6), с. 655-664.5. Сергеев Г. Б., Батюк В. А. Криохимия. М.: Химия, 1978, 296 с.6. Шавлов А. В., Писарев А. Д., Рябцева А. А. Динамика электропроводности пленок металловво льду при его структурном превращении. Рекомбинационно-фононный механизм ускорения коррозии // Криосфера Земли, 2006, т. 10(3), с. 42–48.7. Шавлов А. В., Писарев А. Д., Рябцева А. А. Коррозия пленок металлов во льду. Динамикаэлектропроводности пленок // Журнал физической химии, 2007, т. 81(7), с. 1180–1185.8. Великоцкий М. А. Коррозионная активность грунтов в различных природных зонах // ВестникМосковского университета. Серия 5: География, 2010(1), с. 21–27.9. Лотник С. В., Казаков В. П. Низкотемпературная хемилюминесценция. М.: Наука, 1987, 176 с.10. Шабатина Т. И., Сергеев Г. Б. Реакции при низких температурах в химии наносистем // Успе-хи химии, 2003, т. 72(7), с. 643–663.11. Chaplin M. Water Structure and Science. Режим доступа: http://www.lsbu.ac.uk/water/chaplin.html(дата обращения: 23.09.2019)12. Rosenfeld D., Woodley W. L. Deep convective clouds with sustained supercooled liquid water downto - 37.5 °C // Nature, 2000, v. 405(6785), pp. 440–442. DOI: https://doi.org/10.1038/3501303013. Бордонский Г. С., Орлов А. О. Признаки возникновения льда “0” в увлажненных нанопористыхсредах при электромагнитных измерениях // Письма в Журнал экспериментальной и теоретическойфизики, 2017, т. 105(7-8), с. 483-488. DOI: https://doi.org/10.7868/S0370274X1708004514. Limmer D. T., Chandler D. The putative liquidliquid transition is a liquid-solid transition in atomisticmodels of water // Journal of Chemical Physics, 2011, v. 135, pp. 134503/10. DOI: https://doi.org/10.1063/1.364333315. Mishima O. Volume of supercooled water under pressure and the liquid-liquid critical point // Journalof Chemical Physics, 2010, v. 133(14), p. 144503/6. DOI: https://doi.org/10.1063/1.348799916. Handle P. H., Loerting T., Sciortino F. Supercooled and glassywater:Metastable liquid(s), amorphoussolid(s), and a no-man’s land // Proceedings of the National Academy of Sciences USA, 2017, v. 114(51),pp. 13336-13344. DOI: https://doi.org/10.1073/pnas.170010311417. Speedy R. J., Angell C. A. Isothermal compressibility of supercooled water and evidence for a thermodynamic singularity at -45°C // The Journal of Chemical Physics, 1976, v. 65(3), pp. 851-858. DOI:https://doi.org/10.1063/1.43315318. Анисимов М. А. Холодная и переохлажденная вода как необычный сверхкритический флю-ид // Сверхкритические флюиды: Теория и практика, 2012, т. 7(2), с. 19–37.19. Бордонский Г. С., Гурулев А. А. Экспериментальное доказательство существования линииВидома по особенностям поведения водорода в нанопористом силикате при -45°C и атмосферномдавлении // Письма в Журнал технической физики, 2017, т. 43(8), с. 34–40. DOI: https://doi.org/10.21883/PJTF.2017.08.44541.1658120. Бордонский Г. С., Гурулев А. А., Крылов С. Д., Цыренжапов С.В. Использование микроволновойспектроскопии для изучения состояния переохлажденной воды // Конденсированные среды и меж-фазные границы, 2019, т. 21(1), с. 16–23. DOI: https://doi.org/10.17308/kcmf.2019.21/71221. Castrillуn R. V. S., Giovambattista N., Aksay I. A., Debenedetti P. G. Structure and energetics of thin fi lmwater // Journal of Physical Chemistry C, 2011, v. 115(11), pp. 4624–4635. DOI: https://doi.org/10.1021/jp108396722. Меньшиков Л. И., Меньшиков П. Л., Федичев П. О. Феноменологическая модель гидрофобных и гидрофильных взаимодействий // Журнал экспериментальной и теоретической физики, 2017,т. 152(6), с. 1374–1392. DOI: https://doi.org/10.7868/S004445101712021523. Cerveny S., Mallamace F., Swenson J., Vogel M., Xu L. Confi ned Water as Model of Supercooled Water //Chemical Reviews, 2016, v. 116(13), pp. 7608–7625. DOI: https://doi.org/10.1021/acs.chemrev.5b0060924. Горбатый Ю. Е., Бондаренко Г. В. Сверхкритическое состояние воды // Сверхкритическиефлюиды: Теория и практика, 2007, т. 2(2), с. 5–19.25. Паташинский А. З., Покровский В. Л. Флуктуационная теория фазовых переходов. М.: Наука,1982, 381 с.26. Пригожин И., Кондепуди Д. Современная термодинамика. От тепловых двигателей до диссипативных структур. М.: Мир, 2002, 461 с.27. Ландау Л. Д., Лифшиц Е. М. Теоретическая физика. Том. 5. Статистическая физика. Часть 1.М.: Физматлит, 2002, 616 с.28. Sellberg J. A., Huang C., McQueen T. A., Loh N. D., Laksmono H., Schlesinger D., Sierra R. G.,Nordlund D., Hampton C. Y., Starodub D., Deponte D. P., Beye M., Chen C., Martin A. V., Barty A.,Wikfeldt K. T., Weiss T. M., Caronna C., Feldkamp J., Skinner L. B., Seibert M. M., Messerschmidt M., WilliamsG. J., Boutet S., Pettersson L. G. M., Bogan M. J., Nilsson A. Ultrafast X-ray probing of water structurebelow the homogeneous ice nucleation temperature // Nature, 2014, v. 510(7505), pp. 381–384. DOI: https://doi.org/10.1038/nature1326629. Goy C., Potenza M. A. C., Dedera S., Tomut M., Guillerm E., Kalinin A., Voss K.-O., Schottelius A.,Petridis N., Prosvetov A., Tejeda G., Fernández J. M., Trautmann C., Caupin F., Glasmacher U., Grisenti R. E.Shrinking of Rapidly Evaporating Water Microdroplets Reveals their Extreme Supercooling // Physical ReviewLetters, 2018, v. 120(1), p. 015501/6. DOI: https://doi.org/10.1103/PhysRevLett.120.01550130. Сергеев Г.Б. Нанохимия. М.: Книжный дом «Университет», 2015, 384 с.
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Scheibner, Kara A., Diane Heiser, Ian M. Kaplan, Wen-Chih Cheng, MinJung Kim, Shubhada Shashikant Bharne, Sebastien Morisot, and Curt I. Civin. "MicroRNA Maestros of Hematopoiesis." Blood 116, no. 21 (November 19, 2010): SCI—32—SCI—32. http://dx.doi.org/10.1182/blood.v116.21.sci-32.sci-32.

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Abstract Abstract SCI-32 MicroRNAs (miRs) inhibit stability and/or translation of mRNAs, usually by binding to specific sites in the 32′UTRs of their target mRNAs. Due to imperfect (i.e. partially complementary) miR:mRNA base-pairing, miRs can block translation of many mRNAs and serve as powerful master switches to regulate cell functions. Therefore, we profiled miR expression in human CD34+ hematopoietic stem-progenitor cells (HSPCs) and combined human HSPC miR expression, mRNA expression, and miR-mRNA target predictions to hypothesize that certain HSPC-expressed miRs (HE-miRs) target several mRNAs critical to hematopoiesis. On this informatic basis, we formulated a model of hematopoietic differentation in which many genes specifying hematopoietic differentiation are expressed by early HSPCs, but held in check by miRs [1]. In addition, we noted that the miR-23a cluster (i.e. adjacent, co-transcribed miR-23a, miR-27a, and miR-24-2) is not expressed or is expressed at levels >2-fold lower in 50% of acute myeloid leukemias and 80% of acute lymphoid leukemias tested compared to normal human HSPCs. ‘Re-expressing’ 1 or more of these miR-23a cluster members in leukemia cells promotes their apoptosis and reduces their proliferation, thus suggesting that these miRs have a tumor suppressive role. We have identified YWHAQ (14-3-3q) and several other 14-3-3 isoforms, which are anti-apoptotic and have established roles as oncogenes, as miR-23a cluster target molecules. Artificial manipulation of these HE-miRs and their target genes may lead to novel strategies for leukemia treatment and/or for expansion of normal HSPCs. Since the CD34+ HSPCs that we studied initially include rare stem cells and various stages of progenitors, we have expanded our miR profiling to more highly purified subsets of mouse HSPCs. Several previously described (e.g. miR-155 [1], miR-451 [2], miR-146 [3]) and novel HE-miRs are expressed differentially in lineages/stages of HSPCs, and their selective expression has been confirmed in human HSPC subsets. We are using cellular gain- and loss-of-function approaches with hematopoietic functional assays to determine whether these HE-miRs control human hematopoiesis. Understanding the effects of HE-miRs in hematopoiesis may elucidate hematopoietic and general stem cell biologic mechanisms. 1. Georgantas RW, 3rd, Hildreth R, Morisot S, Alder J, Liu CG, Heimfeld S, Calin GA, Croce CM, Civin CI. CD34+ hematopoietic stem-progenitor cell microRNA expression and function. A circuit diagram of differentiation control. Proc Natl Acad Sci USA. 2007;104:2750–2755. 2. Dore LC, Amigo JD, Dos Santos CO, Zhang Z, Gai X, Tobias JW, Yu D, Klein AM, Dorman C, Wu W, Hardison RC, Paw BH, Weiss MJ. A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci USA. 2008;105:3333–3338. 3. Starczynowski DT, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, Hirst M, Hogge D, Marra M, Wells RA, Buckstein R, Lam W, Humphries RK, Karsan A. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med. 2010;16:49–58. Disclosures: No relevant conflicts of interest to declare.
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Paufler, P. "Landolt-Börnstein. Zahlenwerte und Funktionen aus Naturwissenschaften und Technik. Neue Serie. Gesamtherausgeber: O. MADELUNG Gruppe III: Kristall- und Festkörperphysik Band 7. Kristallstrukturdaten anorganischer Verbindungen. W. Pies, A. Weiss. Teil d. Schlüsselelemente: Si, Ge, Sn, Pb; B, Al, Ga, In, Tl; Be. d 1: Schlüsselelemente Si, Ge, Sn, Pb,. D lγ: Schlüsselelemente Ge, Sn, Pb. Herausgeber: K.-H. Hellwege, A. M. Hellwege. Springer-Verlag Berlin, Heidelberg, New York, Tokyo, 1986, XXV + 215 Seiten. DM 630,—. ISBN 3-540-16169-4." Crystal Research and Technology 22, no. 9 (September 1987): 1158. http://dx.doi.org/10.1002/crat.2170220911.

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Kusuma Wijayanti, Puspita Adhi, and Surya Cahyadi. "Antecedents-Consequences Modification to Decrease Hyper-activity and Improve Attention of Child with ADHD." JPUD - Jurnal Pendidikan Usia Dini 13, no. 2 (November 30, 2019): 232–48. http://dx.doi.org/10.21009/jpud.132.03.

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The prevalence of ADHD children increases every year. Some researchers have shown that psychosocial behavior therapy (antecedents-consequences modification) was effective to decrease hyperactivity and increase attention to ADHD children. This study aims to find out the effectiveness of antecedents-consequences modification by parents and teachers to decrease hyperactivity and increase attention to a 6 years old boy with ADHD. The study was a single case experimental design. Psychosocial behavior therapy has been used with antecedents-consequences modification. The antecedents-consequences modification was applied by teacher at school and parents at home. Data were analyzed using Wilcoxon Signed Rank Test. Results showed that there’s a significant decrease of hyperactivity behavior and significant increase of doing his assignment both at school and also at home. Not only about the content of behavior therapy itself, but how to give the therapy is important. Parents and teacher should do the therapy consistently, immediately, specifically and saliency to reach the target of intervention. Keywords: ADHD Children, Antecedents, Consequences, Modification Reference: (APA), A. A. P. (2013). Diagnostic and Manual of Mental Disorder (5th ed.). Arlington: American Psychiatric Association. Amalia, R. (2018). Intervensi terhadap Anak Usia Dini yang Mengalami Gangguan ADHD Melalui Pendekatan Kognitif Perilaku dan Alderian Play Therapy. Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini, 2(1), 27. https://doi.org/10.31004/obsesi.v2i1.4 Anastopoulos, A.D; Farley, S. . (2003). A Cognitive Behavioural Training Program for Parents of Children with Attention-Deficit/Hyperactivity Disorder. In W. J. Kazdin, Alan E (Ed.), Evidence-based psychotherapies for children and adolescents (pp. 187–203). New York: Guildford Press. Barkley, Russell A; DuPaul, G.L ; McMurray, M. . (1990). A comprehensive evaluation of attention deficit disorder with and without hyperactivity. Journal of Consulting and Clinical Psychology, 58, 775–789. Barkley, R. A. (2006). Attention-deficit hyperactivity disorder : A handbook for diagnosis and treatment (3rd ed.). New York City: Guildford Press. Barlow, D.H ; Hersen, M. (1984). Single case experimental design : Strategies for studying behavior change (2nd ed.). New York: Pergamon Press. Baumeister, S., Wolf, I., Holz, N., Boecker-Schlier, R., Adamo, N., Holtmann, M., … Brandeis, D. (2018). Neurofeedback Training Effects on Inhibitory Brain Activation in ADHD: A Matter of Learning? Neuroscience, 378, 89–99. https://doi.org/10.1016/j.neuroscience.2016.09.025 Cantwell, D. P., & Baker, L. (1991). Association between attention deficit-hyperactivity disorder and learning disorders. Journal of Learning Disabilities, 24(2), 88–95. https://doi.org/10.1177/002221949102400205 Center for Children and Families. (2019). Evidence-based Psychosocial Treatment for ADHD Children and Adolescents. Retrieved from http://ccf.fiu.edu Davidson, G. C. (2010). Abnormal Psychology. New Jersey: Wiley. DuPaul, George; Stoner, G. (2003). ADHD in the schools. New York: Guildford Press. DuPaul, G., & Weyandt, L. (2006). School-based intervention for children with attention deficit hyperactivity disorder: Effects on academic, social, and behavioural functioning. International Journal of Disability, Development and Education, 53(2), 161–176. https://doi.org/10.1080/10349120600716141 Erinta, D. B. M. S. (2012). Efektivitas penerapan terapi permainan sosialisasi untuk menurunkan perilaku impulsif pada anak dengan attention deficit hyperactive disorder (ADHD). Jurnal Psikologi : Teori & Terapan, 3(1). Evans, Steven W; Owens, Julie; Bunford, M. N. (2014). Evidence-Based Psychosocial Treatments for Children and Adolescents with Attention-Deficit/Hyperactivity Disorder. Journal Clinical Child Adolescence Psychology, 43(4), 527–551. https://doi.org/10.1038/jid.2014.371 Fabiano, G. A., Pelham, W. E., Coles, E. K., Gnagy, E. M., Chronis-Tuscano, A., & O’Connor, B. C. (2009). A meta-analysis of behavioral treatments for attention-deficit/hyperactivity disorder. Clinical Psychology Review, 29(2), 129–140. https://doi.org/10.1016/j.cpr.2008.11.001 Gerdes, A. C., Hoza, B., & Pelham, W. E. (2003). Attention-deficit/hyperactivity disordered boys’ relationships with their mothers and fathers: Child, mother, and father perceptions. Development and Psychopathology, 15(2), 363–382. https://doi.org/10.1017/S0954579403000208 Haas, S. M., Waschbusch, D. A., Pelham, W. E., King, S., Andrade, B. F., & Carrey, N. J. (2011). Treatment response in CP/ADHD children with callous/unemotional traits. Journal of Abnormal Child Psychology, 39(4), 541–552. https://doi.org/10.1007/s10802-010-9480-4 Helseth, S. A., Waschbusch, D. A., Gnagy, E. M., Onyango, A. N., Burrows-MacLean, L., Fabiano, G. A., … Pelham, W. E. (2015). Effects of behavioral and pharmacological therapies on peer reinforcement of deviancy in children with ADHD-Only, ADHD and conduct problems, and controls. Journal of Consulting and Clinical Psychology, 83(2), 280–292. https://doi.org/10.1037/a0038505 Hidayati, DM Ria ; Purwandari, E. (2010). Time Out : Alternatif Modifikasi Perilaku Anak ADHD (Attention Deficit/ Hyperacitivity Disorder). Indigenous, Jurnal Ilmiah Berkala Psikologi, 12(2), 101–114. Hinshaw, S. P., Owens, E. B., Wells, K. C., Kraemer, H. C., Abikoff, H. B., Arnold, L. E., … Wigal, T. (2000). Family processes and treatment outcome in the MTA: Negative/ineffective parenting practices in relation to multimodal treatment. Journal of Abnormal Child Psychology, 28(6), 555–568. https://doi.org/10.1023/A:1005183115230 Hinshaw, Stephen P., Owens, E. B., Zalecki, C., Huggins, S. P., Montenegro-Nevado, A. J., Schrodek, E., & Swanson, E. N. (2012). Prospective follow-up of girls with attention-deficit/hyperactivity disorder into early adulthood: Continuing impairment includes elevated risk for suicide attempts and self-injury. Journal of Consulting and Clinical Psychology,80(6), 1041–1051. https://doi.org/10.1037/a0029451 Jackson, N. A. (2003). A Survey of Music Therapy Methods and Their Role in the Treatment of Early Elementary School Children with ADHD. Journal of Music Therapy, 40(4), 302–323. https://doi.org/10.1093/jmt/40.4.302 Johnston, Charlotte; Mash, E. J. (2001). Families of Children With Attention-Deficit/Hyperactivity Disorder : Review and Recommendations for Future Research. Clinical Child and Family Psychology Review, 4(3), 183–207. Jr, W. E. P., Fabiano, G. A., & Pelham, W. E. (2008). Evidence-Based Psychosocial Treatments for Attention- Deficit / Hyperactivity Disorder (Vol. 4416). https://doi.org/10.1080/15374410701818681 Kaiser, N. M., McBurnett, K., & Pfiffner, L. J. (2011). Child ADHD severity and positive and negative parenting as predictors of child social functioning: Evaluation of three theoretical models. Journal of Attention Disorders, 15(3), 193–203. https://doi.org/10.1177/1087054709356171 Kazdin, A. E. (1984). Behavior Modification in Applied Settings. New York: Dorsey Press. Krasny-Pacini, A., & Evans, J. (2018). Single-case experimental designs to assess intervention effectiveness in rehabilitation: A practical guide. Annals of Physical and Rehabilitation Medicine, 61(3), 164–179. https://doi.org/10.1016/j.rehab.2017.12.002 Langberg, J. M., Molina, B. S. G., Arnold, L. E., Epstein, J. N., Altaye, M., Hinshaw, S. P., … Hechtman, L. (2011). Patterns and predictors of adolescent academic achievement and performance in a sample of children with attention-deficit/hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 40(4), 519–531. https://doi.org/10.1080/15374416.2011.581620 Nigg, J.T ; Barkley, R. . (2014). (Attention-deficit Hyperactivity Disorder). In R. A. Barkley (Ed.), E-book Pediatric เรื่องPsychiatry (Third Edit, Vol. 54, pp. 1–17). Retrieved from http://www.thaipediatrics.org/pages/Doctor/Download/48aedb8880cab8c45637abc7493ecddd:e0a186938dc3b74657fd46d32fac5fe6 Pastor, P., Reuben, C., Duran, C., & Hawkins, L. J. (2015). Association between diagnosed ADHD and selected characteristics among children aged 4-17 years: United States, 2011-2013. NCHS Data Brief, (201), 201. Patterson, G. . (1982). Coercive Family Process. Eugene: Castalia. Pfiffner, L. J ; Barkley, R. . (1990). Educational Placement and Classroom Management. In R. A. Barkley (Ed.), Attention Deficit Hyperactivity Disorder : A Handbook for Diagnosis and Treatment. New York: Guildford Press. Pfiffner, Linda J; Barkley, R; DuPaul, G. (2006). Treatment of ADHD in school settings. In R. A. Barkley (Ed.), Attention-deficit hyperactivity disorder: A handbook for diagnosis and treatment (3th ed., pp. 547–589). New York: Guildford Press. Pfiffner, L. J., Calzada, E., & McBurnett, K. (2000). Interventions to enhance social competence. Child and Adolescent Psychiatric Clinics of North America, 9(3), 689–709. https://doi.org/10.1016/s1056-4993(18)30113-5 Pfiffner, Linda J., Hinshaw, S. P., Owens, E., Zalecki, C., Kaiser, N. M., Villodas, M., & McBurnett, K. (2014). A two-site randomized clinical trial of integrated psychosocial treatment for ADHD-inattentive type. Journal of Consulting and Clinical Psychology, 82(6), 1115–1127. https://doi.org/10.1037/a0036887 Pfiffner, Linda J, & Haack, L. M. (2014). Behavior Management for School - Aged Children with ADHD. 23, 731–746. Pfiffner, Linda J, Hinshaw, S. P., Owens, E., Zalecki, C., Kaiser, N. M., Villodas, M., & Mcburnett, K. (2015). A two-site randomized clinical trial of Integrated Psychosocial Treatment for ADHD-Inattentive Type. Journal of Consulting and Clinical Psychology, 82(6), 1115–1127. https://doi.org/10.1037/a0036887.A Riddle, M. A., Yershova, K., Lazzaretto, D., Paykina, N., Yenokyan, G., Greenhill, L., … Posner, K. (2013). The preschool attention-deficit/hyperactivity disorder treatment study (PATS) 6-year follow-up. Journal of the American Academy of Child and Adolescent Psychiatry, 52(3). https://doi.org/10.1016/j.jaac.2012.12.007 Saputro, D. (2009). ADHD (Attention Deficit/ Hyperactivity Disorder). Jakarta: Sagung Seto. Schunk, D. H. (2012). Learning Theories : An Educational Perspective (6th ed.; Pearson Education, Ed.). Boston. Shriver, M. D., Segool, N., & Gortmaker, V. (2011). Behavior observations for linking assessment to treatment for selective mutism. Education and Treatment of Children, 34(3), 389–411. https://doi.org/10.1353/etc.2011.0023 Suyanto, B. N., & Wimbarti, S. (2019). Program Intervensi Musik terhadap Hiperaktivitas Anak Attention Deficit Hyperactivity Disorder (ADHD). Gadjah Mada Journal of Professional Psychology (GamaJPP), 5(1), 15. https://doi.org/10.22146/gamajpp.48584 Taylor, E. (2009). Developing ADHD. Journal of Child Psychology and Psychiatry, 50, 126–132. Thomas, R., Sanders, S., Doust, J., Beller, E., & Glasziou, P. (2015). Prevalence of attention-deficit/hyperactivity disorder: A systematic review and meta-analysis. Pediatrics, 135(4), e994–e1001. https://doi.org/10.1542/peds.2014-3482 Tran, J. L. A., Sheng, R., Beaulieu, A., Villodas, M., McBurnett, K., Pfiffner, L. J., & Wilson, L. (2018). Cost-Effectiveness of a Behavioral Psychosocial Treatment Integrated Across Home and School for Pediatric ADHD-Inattentive Type. Administration and Policy in Mental Health and Mental Health Services Research, 45(5), 741–750. https://doi.org/10.1007/s10488-018-0857-y Tresco, K. E., Lefler, E. K., & Power, T. J. (2010). Psychosocial Interventions to Improve the School Performance of Students with Attention-Deficit/Hyperactivity Disorder. Mind & Brain : The Journal of Psychiatry, 1(2), 69–74. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21152355%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2998237 U.S. Department of Health and Human Services. (2014). US Department of Health and Human Services. The Health and Well-Being of Children: A Portrait of States and the Nation, 2011-2012. (June), 1–109. Weiss, Gabrielle ; Hechtman, L. T. (1993). Hyperactive Children Grown Up. New York: Guildford Press.
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Rexach, Michael. "Piecing together nuclear pore complex assembly during interphase." Journal of Cell Biology 185, no. 3 (May 4, 2009): 377–79. http://dx.doi.org/10.1083/jcb.200904022.

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All nucleocytoplasmic traffic of macromolecules occurs through nuclear pore complexes (NPCs), which function as stents in the nuclear envelope to keep nuclear pores open but gated. Three studies in this issue (Flemming, D., P. Sarges, P. Stelter, A. Hellwig, B. Böttcher, and E. Hurt. 2009. J. Cell Biol. 185:387–395; Makio, T., L.H. Stanton, C.-C. Lin, D.S. Goldfarb, K. Weis, and R.W. Wozniak. 2009. J. Cell Biol. 185:459–491; Onishchenko, E., L.H. Stanton, A.S. Madrid, T. Kieselbach, and K. Weis. 2009. J. Cell Biol. 185:475–491) further our understanding of the NPC assembly process by reporting what happens when the supply lines of key proteins that provide a foundation for building these marvelous supramolecular structures are disrupted.
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Scarborough, Vernon L., Matthew E. Becher, Jeffrey L. Baker, Garry Harris, and Fred Valdez. "Water and Land at the Ancient Maya Community of La Milpa." Latin American Antiquity 6, no. 2 (June 1995): 98–119. http://dx.doi.org/10.2307/972146.

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The Late Preclassic to Classic period (400 B. C.-A. D. 900) Maya community of La Milpa, Belize, has recently revealed an ancient water and land-use system. As demonstrated at other southern Maya Lowland sites, the Maya created a microwatershed to store and convey water during the four months of seasonal drought. In addition to water conservation measures associated with reservoirs, deliberate channelization, diversion weirs, and postulated fields, the importance of rainy-season erosion control is indicated. Given the ancient population densities identified in the Maya area, coupled with the seasonal scarcity of water, we posit a “skill-oriented” economy.
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Paufler, P. "Landolt-Börnstein, Zahlenwerte und Funktiunen aus Naturwissenschaft und Technik. New Series. Ed. in Chief: K.-H. Hellwege, O. Madelung, Group III: Crystal and Solid State Physics. Vol. 7: Crystal Structure. Data of Inorganic Compounds. W. Pies, A. Weiss. Part d: Key Elements: Si, Ge, Sn, Pb; B, Al, Ga, In, Tl; Be. d 1: Key Elements Si, Ge, Sn, Pb. d 1β: Key Element Si. In cooperation with G. Pieper. Eds. K.-H. Hellwege, A. M. Hellwece. Springer-Verlag Berlin-Heidelberg-New York-Tokyo. 1985. XXV + 506 pages. Hard cover DM 1160, – ISBN 3-540-13930-3." Crystal Research and Technology 21, no. 9 (September 1986): 1184. http://dx.doi.org/10.1002/crat.2170210911.

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Jussli-Melchers, Jill, Carsten Hilbert, Iris Jahnke, Kai Wehkamp, Annette Rogge, Sandra Freitag-Wolf, Heike Kahla-Witzsch, Jens Scholz, and Rainer Petzina. "Reifegrade des Qualitäts- und Risikomanagementsystems am Universitätsklinikum Schleswig-Holstein." Das Gesundheitswesen 80, no. 07 (May 16, 2018): 648–55. http://dx.doi.org/10.1055/a-0600-2607.

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Zusammenfassung Einleitung Qualitäts- und Risikomanagement (QRM) in Krankenhäusern sind nicht nur gesetzlich gefordert, sondern führen maßgeblich zu einer optimierten patienten- und ablauforientierten Krankenversorgung. Zur Evaluation der Reifegrade des QRM-Systems am Universitätsklinikum Schleswig-Holstein (UKSH) wurde ein strukturiertes Analysetool entwickelt, das einfach und effizient anzuwenden ist. Methode Vier Qualitätskriterien – Qualitätssicherung (QS), Critical Incident Reporting System (CIRS), Beschwerdemanagement (BM) und Prozessmanagement (PM) – wurden mittels eines strukturierten Erhebungsbogens zur Eigen- und Fremdbewertung an den beiden Standorten des UKSH in Kiel und Lübeck analysiert. Jedes Qualitätskriterium wiederum wurde in vier Kategorien von A (voll implementiert) bis D (nicht implementiert) eingeteilt. Zunächst fand eine Fremdbewertung durch das zentrale QRM und im Anschluss die Eigenbewertung der insgesamt 46 analysierten Kliniken zu den jeweiligen vier Qualitätskriterien statt. Unstimmigkeiten zwischen Eigen- und Fremdbewertungen wurden in einem kollegialen Dialog gelöst. Letztendlich resultierte aus den erhobenen Daten eine Gesamtreifegradbeurteilung pro Klinik. Ergebnisse Der Gesamtreifegrad A wurde von 3 der 46 Kliniken (6,5%) erzielt. Keine Klinik erhielt die Gesamtreifegradbeurteilung D. 50% aller Kliniken erreichten Reifegrad B und 43,5% Reifegrad C. Die Verteilung der unterschiedlichen vier Qualitätskriterien zeigte insgesamt eine gute Implementierung des Beschwerdemanagements (Reifegrade A und B mit 78,3%) auf, während bei CIRS ein hoher Anteil der Reifegrade C und D (73,9%) vorlag. QS und PM wiesen eine sehr ähnliche Verteilung auf mit den Reifegradbeurteilungen B und C (87% QS; 91% PM). Diskussion Durch das strukturierte Analysetool sind sowohl die Gesamtreifegrade des QRM-Systems an 46 Kliniken des UKSH als auch detailliert die Reifegrade 4 wesentlicher Qualitätskriterien (QS, CIRS, BM, PM) erhoben worden. In der Konsequenz wurde ein umfangreiches Maßnahmenpaket zur Verbesserung des QRM-Systems eingeleitet. Zukünftig werden die Reifegrade im 2 Jahresrhythmus re-evaluiert. Dieses qualitative Reifegradmodell ermöglicht auf einfache und effiziente Weise, präzise Aussagen bezüglich des Vorhandenseins, der Ausprägung und der Weiterentwicklung des Qualitäts- und Risikomanagements zu generieren.
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Bitzer, Johannes. "Kontrazeptive Compliance – warum kommt es immer wieder zum Versagen der kontrazeptiven Therapie?" Therapeutische Umschau 66, no. 2 (February 1, 2009): 137–43. http://dx.doi.org/10.1024/0040-5930.66.2.137.

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Kontrazeptive Compliance bedeutet, dass eine Verhütungsmethode korrekt, d.h. in genau der Weise angewendet wird, wie dies medizinisch von der Methode her erforderlich bzw. vom Arzt her vorgeschrieben ist. Non-Compliance beschreibt das Missverhältnis zwischen korrektem und realem Anwendungsverhalten. Verschiedene Indikatoren weisen darauf hin, dass die kontrazeptive Compliance ungenügend ist. In den meisten Studien wird eine Rate von 40–50% ungeplanter Schwangerschaften angegeben; knapp die Hälfte dieser Schwangerschaften enden in Schwangerschaftsabbrüchen, deren Zahl weiterhin hoch ist. Bei hormonalen und Barrieremethoden besteht eine deutliche Diskrepanz zwischen der Effizienz bei korrekter Anwendung versus der Effizienz bei typischer Anwendung. Die Abbruchraten der kontrazeptiven Therapie nach einem Jahr sind bis zu 50%. Gründe für Non-Compliance sind a) Mangelnde oder fehlende Motivation durch Ambivalenz bezüglich Kinderwunsch, sowie sexuelle und partnerschaftliche Konflikte; (b) Kognitive Faktoren (Fehlinformationen, irrationale Ängste); (c) Erschwerter Zugang zu kontrazeptiven Methoden; (d) Verhaltensfehler (Vergessen, Verlieren) und (e) Nebenwirkungen der Methoden. Drei Strategien zur Verbesserung der Compliance werden eingesetzt: a) Verbesserung der Beratung und Betreuung; b) Entwicklung von Methoden, die keine oder nur geringe Compliance erfordern; c) Verbesserung der Lebensqualität bei Anwendung kontrazeptiver Methoden durch Minderung negativer Nebenwirkungen und Steigerung des nicht kontrazeptiven Nutzens.
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Khorida, Ninik, Mamok Suprapto, and Syafi’i. "The concept of Lomaya and Pilohayanga weir rehabilitation based on technical and economic aspects." MATEC Web of Conferences 195 (2018): 05009. http://dx.doi.org/10.1051/matecconf/201819505009.

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Lomaya and Pilohayanga Weirs are located in Limboto-Bone- Bolango River, Bone Bolango District, and Gorontalo Province. Pilohayanga Weir is located at 1,500 meters downstream of Lomaya Weir, it has 1,045 hectares of irrigation services area while also serving as a supplier of raw water requirements. The damage that occurred in Pilohayanga Weir resulted in its decreasing function, and also resulted in unmet irrigation and raw water needs. Meanwhile, Lomaya Weir has 3,148 hectares of irrigation services area. The aim of this research is to find the optimal solution among several alternative design concepts to meet Pilohayanga Weir’s water needs by supplying water from Lomaya Weir, considering both the technical aspects of hydraulic and the cost of implementation which must be within the economical boundary. In conclusion, the exact solution required is by the addition of several designs, these include: a) creating a new intake area on the right side of Pilohayanga Weir; b) creating an additional channel, flushing out sediment from Lomaya Weir; c) creating sand trap; and d) creating a carrier which will be channelled to Pilohayanga Irrigation Area.
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Kašuba, Maja, Enrico Lehnhardt, Irina Šramko, and Stanislav Zadnikov. "Eisenmetallurgie in der Bronzezeit Osteuropas. Die archäologischen Quellen und ihre Interpretation." Praehistorische Zeitschrift 94, no. 1 (December 1, 2019): 158–209. http://dx.doi.org/10.1515/pz-2019-0001.

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Zusammenfassung Im Beitrag werden mehr als 180 Gegenstände aus Eisen ausgewertet, die zwischen dem 3. Jahrtausend v. Chr. und dem Anfang des 1. Jahrtausends v. Chr. im Raum zwischen den Karpaten und dem Ural gefunden wurden. Die Objekte stammen von verschiedenen Fundorten und aus 15 archäologischen Kulturen. Der zeitliche Rahmen der Studie entspricht der Bronzezeit und dem Übergang zur frühen Eisenzeit auf Grundlage der aktuellen chronologischen Vorstellungen in Osteuropa. Der Auswertung liegt eine umfangreiche Datenbank zugrunde. Vorgestellt und analysiert werden: a) die Anzahl der Eisenobjekte und ihre Verbreitung; b) die Kategorien der Gegenstände, die aus Eisen gefertigt wurden; c) die Dynamik und die Art und Weise wie Eisen in Gebrauch kam; d) forschungsgeschichtliche Aspekte. Die Auswertung des Materialkorpus mit den aktualisierten Daten und der frühen Funde aus Eisen sowie Schlacken ergibt ein konkretes Bild ihrer quantitativen und qualitativen Verteilung über zwei Jahrtausende in dem Arbeitsgebiet. Die Untersuchung wirft ein neues Licht auf die Tendenzen in der frühen Eisennutzung in Osteuropa. Das Fazit der Autoren, dass Osteuropa als ein eigenständiges Zentrum bei der Herausbildung der Eisenmetallurgie in der Alten Welt anzusehen ist, muss noch weiter überprüft und durch moderne naturwissenschaftliche Analysen abgesichert werden.
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Gomes, Silvia Janaina Silveira, and Nilma Margarida de Castro Crusoé. "Prática formativa no ensino superior na perspectiva da Fenomenologia Sociológica: narrativa de estudantes (Formative practice in higher education from perspective of Sociological Phenomenology: student narrative)." Revista Eletrônica de Educação 14 (March 3, 2020): 3446062. http://dx.doi.org/10.14244/198271993446.

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This article aims to present a research result on meanings of formative practice in the context of Institutional Program of Initiation to Teaching (PIBID). As a research method, adopted the sociological phenomenology that allowed, among other aspects, to understand the symbolic dimension of formative practice for each students. One of the principles of that method consists in the perspective that senses emerge from the relation with the other, bringing to surface the idea of intersubjectivity, thus configuring a phenomenology of social relations. In order to access the senses produced in the world of life, in encounter of consciousness with the world, in specific case of this research, in the context of formative practice, semistructured interview has been used with five undergraduate students invited to give a break in the flow of life for think about teacher training. The senses revealed in this study are close to the concern with student learning, having the teacher as the main driver of this process, as well as the student and his way of learning. There are also senses about difficulties that each student presents in application of knowledge and draws attention to the relation between knowledge and reality. Sense about the teacher-student relationship reveals concern with professional and human dimension as well as authority of teacher's knowledge in the classroom with students.Resumo Este artigo tem como objetivo apresentar resultado de pesquisa sobre sentidos de prática formativa no contexto do Programa Institucional de Bolsa de Iniciação à Docência (PIBID). Como método de pesquisa adotou-se a Fenomenologia Sociológica que permitiu, entre outros aspectos, compreender a dimensão simbólica da prática formativa para cada um dos estudantes. Um dos princípios desse método consiste na perspectiva de que os sentidos nascem da relação com o outro trazendo à tona a ideia de intersubjetividade configurando, assim, uma Fenomenologia das relações sociais. Para acessar os sentidos produzidos no mundo da vida, no encontro da consciência com o mundo, no caso especifico desta pesquisa, no contexto da prática formativa, foi utilizada a entrevista semiestruturada com cinco estudantes de licenciaturas diversas, convidados a suspender o fluxo da vida para pensar sobre sua formação docente. Os sentidos revelados neste estudo se aproximam na preocupação com a aprendizagem do estudante tendo o professor como principal condutor desse processo como, também, o estudante e seu modo de aprender. Aparecem, também, sentidos a respeito das dificuldades que cada aluno apresenta na aplicação do conhecimento e chama à atenção para a relação entre conhecimento e realidade. Sentidos sobre a relação professor-estudante revelam preocupação com a dimensão profissional e humana, bem como a autoridade do conhecimento do professor, em sala de aula, com os estudantes.ResumenEste artículo tiene como objetivo presentar resultados de investigación sobre sentidos de práctica formativa en el contexto del Programa Institucional de Beca de Iniciación a la Docencia (PIBID). Como método de investigación se adoptó si la fenomenología sociológica que permitió, entre otros aspectos, comprender la dimensión simbólica de la práctica formativa para cada uno de los estudiantes. Uno de los principios de este método consiste en la perspectiva de que los sentidos nacen de la relación con el otro trayendo a la superficie la idea de intersubjetividad, configurando así una fenomenología de las relaciones sociales. Para acceder a los sentidos producidos en el mundo de la vida, en el encuentro de la conciencia con el mundo, en el caso específico de esa investigación, en el contexto de la práctica formativa, se utilizó la entrevista semiestructurada con cinco estudiantes de licenciaturas diversas, invitados a suspender el flujo de la vida para pensar en su formación docente. Los sentidos revelados en este estudio se aproximan a la preocupación por el aprendizaje del estudiante teniendo el profesor como principal conductor de ese proceso como, también, el estudiante y su modo de aprender. Aparecen, también, sentidos respecto a las dificultades que cada alumno presenta en la aplicación del conocimiento y llama la atención sobre la relación entre conocimiento y realidad. Los sentidos sobre la relación profesor-estudiante revelan preocupación por la dimensión profesional y humana así como la autoridad del conocimiento del profesor, en el aula, con los estudiantes.Palavras-chave: Ensino superior, Fenomenologia sociológica, Prática formativa.Keywords: Higher education, Sociological phenomenology, Formative practice.Palabras clave: Enseñanza superior, Fenomenología sociológica, Práctica formativa.ReferencesAMADO, J. Manual de investigação qualitativa em educação. Portugal: Imprensa da Universidade de Coimbra, 2014.AMBROSETTI, N. B. et al. Contribuições do PIBID para a formação inicial de professores: o olhar dos estudantes. Educação em Perspectiva, Viçosa, v. 4, n. 1, p. 151-174, jan./jun. 2013. Disponível em http://www.seer.ufv.br/seer/educacaoemperspectiva/index.php/ppgeufv/article/viewFile/405/106 Acesso em 10/03/2017.ASSIS, A. S. de. Contribuições do PIBID para a valorização dos professores: o que dizem as teses e dissertações? 38ª Reunião Nacional da ANPEd – 01 a 05 de outubro de 2017, UFMA – São Luís. Disponível em http://38reuniao.anped.org.br/sites/default/files/resources/programacao/trabalho_38anped_2017_GT08_1256.pdf Acesso em 18/11/2017.BRASIL. Decreto nº 7.219, de 24 de junho de 2010. Dispõe sobre o Programa Institucional de Bolsa de Iniciação à Docência – Pibid. Disponível em http://www.planalto.gov.br/ccivil_03/_Ato2007-2010/2010/Decreto/D7219.htm Acesso em 08/03/2017.BRASIL. Lei nº 11.502, de 11 de julho de 2007. Modifica as competências e a estrutura organizacional da fundação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES, de que trata a Lei no 8.405, de 9 de janeiro de 1992; e altera as Leis nos 8.405, de 9 de janeiro de 1992, e 11.273, de 6 de fevereiro de 2006, que autoriza a concessão de bolsas de estudo e de pesquisa a participantes de programas de formação inicial e continuada de professores para a educação básica. Disponível em https://www.planalto.gov.br/ccivil_03/_Ato2007-2010/2007/Lei/L11502.htm Acesso em 08/03/2017.BRASIL. Portaria Normativa nº 38, de 12 de dezembro de 2007. Ministério da Educação. Dispõe sobre o Programa Institucional de Bolsa de Iniciação à Docência. Disponível em https://www.capes.gov.br/images/stories/download/legislacao/Portaria_Normativa_38_PIBID.pdf Acesso em 08/03/2017.CRUSOÉ, Nilma Margarida de Castro. Subprojeto de Pedagogia: A organização da prática pedagógica dos professores dos três (03) anos iniciais do Ensino Fundamental de nove (09) anos: articulação e continuidade da trajetória escolar. In: BAHIA, Projeto Institucional Microrrede de ensino-aprendizagem-formação. PIBID/UESB, Vitória da Conquista, Bahia, 2012.CRUSOÉ, Nilma Margarida de Castro. Prática Pedagógica interdisciplinar na escola fundamental: sentidos atribuídos pelas professoras. Curitiba, PR:CRV, 2014.FELÍCIO, H. M. dos S. O PIBID com “terceiro espaço” de formação inicial de professores. Rev. Diálogo Educ., Curitiba, V. 14. n. 42, p. 415-434, maio/ago. 2014. Disponível em http://www2.pucpr.br/reol/index.php/dialogo?dd99=pdf&dd1=12752 Acesso em 03/07/2017.FREIRE, P. Professora sim, tia não: cartas a quem ousa ensinar. São Paulo: Olho Dágua, 1997.FREIRE, P. Pedagogia da autonomia: saberes necessários à prática educativa. 36 ed. São Paulo: Paz e Terra, 1996.GATTI, B.; BARRETTO, E. S. de S.; ANDRÉ, M. E. D. A. Políticas docentes no Brasil: um estado da arte. Brasília: UNESCO, 2011. Disponível em http://unesdoc.unesco.org/images/0021/002121/212183POR.pdf Acesso em 10/03/2017.HUSSERL, Edmund. Investigações lógicas: segundo volume, parte I: investigações para a fenomenologia e a Teoria do conhecimento. Rio de Janeiro: Forense, 2015.HUSSERL, Edmund. Ideias para uma fenomenologia pura e para uma filosofia fenomenológica: introdução geral à fenomenologia pura. Aparecida, SP: Ideias & Letras, 2006. MEC/UFRGS. Projeto de cooperação técnica MEC e UFRGS para construção de orientações curriculares para a Educação Infantil. Brasília, 2009. Disponível em http://portal.mec.gov.br/dmdocuments/relat_seb_praticas_cotidianas.pdf Acesso em 24/01/2019.MINAYO, M. C. de S. O desafio do conhecimento: pesquisa qualitativa em saúde. 12 ed. São Paulo: Hucitec, 2010.PROJETO INSTITUCIONAL DE BOLSA DE INICIAÇÃO À DOCÊNCIA – PIBID. Universidade Estadual do Sudoeste da Bahia – UESB. Microrrede de ensino-aprendizagem-formação. 2012. Disponível em http://www.uesb.br/links/2013/05/fapesb/projeto_institucional_2012.pdf Acesso em 04/03/2017.SAVIANI, D. Pedagogia histórico-crítica: primeiras aproximações. 11 ed. rev. Campinas, SP: Autores Associados, 2011. (Coleção Educação contemporânea).SAVIANI, D. Escola e democracia. 32 ed. Campinas, SP: Autores Associados, 1999. (Coleção Polêmicas do nosso tempo).SCHUTZ, A. Sobre fenomenologia e relações sociais. Edição e organização: Helmut T. R. Wagner. Tradução de Raquel Weiss. Petrópolis, RJ: Vozes, 2012.ZEICHNER, K. Repensando as conexões entre a formação na universidade e as experiências de campo na formação de professores em faculdades e universidades. Educação, Santa Maria, v. 35, n. 3, p. 479-504, set./dez. 2010. Disponível em https://periodicos.ufsm.br/reveducacao/article/view/2357/1424 Acesso em 20/05/2017.e3446062
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Salas-Arcos, Lucía, Carlos Lara, and Juan Francisco Ornelas. "Reproductive biology and nectar secretion dynamics of Penstemon gentianoides (Plantaginaceae): a perennial herb with a mixed pollination system?" PeerJ 5 (August 9, 2017): e3636. http://dx.doi.org/10.7717/peerj.3636.

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Abstract:
Background In many plant species, pollination syndromes predict the most effective pollinator. However, other floral visitors may also offer effective pollination services and promote mixed pollination systems. Several species of the species-rich Penstemon (Plantaginaceae) exhibit a suite of floral traits that suggest adaptation for pollination by both hymenopterans and hummingbirds. Transitions from the ancestral hymenopteran pollination syndrome to more derived hummingbird pollination syndrome may be promoted if the quantity or quality of visits by hummingbirds is increased and if the ancestral pollinator group performs less efficiently. The quantification of such shifts in pollination systems in the group is still limited. We aimed to investigate floral traits linked to this pollination syndrome in Penstemon gentianoides with flowers visited by bumblebees and hummingbirds. Methods We investigated the floral biology, pollinator assemblages, breeding system and nectar production patterns ofP. gentianoides inhabiting a temperate montane forest in central Mexico. Pollination experiments were also conducted to assess the pollinator effectiveness of bumblebees and hummingbirds. Results P. gentianoides flowers are protandrous, with 8-d male phase (staminate) flowers, followed by the ∼1–7 d female phase (pistillate phase). Flowers display traits associated with hymenopteran pollination, including purple flowers abruptly ampliate-ventricose to a broad throat with anthers and stigmas included, and long lifespans. However, the nectar available in the morning hours was abundant and dilute, traits linked to flowers with a hummingbird pollination syndrome. Two hummingbird species made most of the visits to flowers, Selasphorus platycercus (30.3% of all visits), followed by Archilochus colubris (11.3%). Bumblebees (Bombus ephippiatus, B. huntii and B. weisi) accounted for 51.8% of all recorded visits, but their foraging activity was restricted to the warmer hours. Hummingbirds made more foraging bouts and visited more flowers than hymenopteran species. Flowers experimentally pollinated by B. ephippiatus produced significantly more fruits than those pollinated by S. platycercus. However, there was no statistical difference in the number of seeds produced per fruit when a bumblebee or a hummingbird was the pollinator. Conclusions We have shown that bumblebees and hummingbirds visit and pollinate P. gentianoides flowers. Despite floral traits resembling the hymenoptera pollination syndrome, flowers of P. gentianoides offer characteristic nectar rewards to flowers with a hummingbird pollination syndrome. Although pollination efficiency is higher among flowers visited by hymenoptera, the noteworthy percentage of fruit production and number of seeds per fruit derived from hummingbird pollination highlights the importance of hummingbirds as a functional group of pollinators that might have potential evolutionary consequences to the plants.
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